33:
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167:
An expectorant increases bronchial secretions and mucolytics help loosen thick bronchial secretions. Expectorants reduce the thickness or viscosity of bronchial secretions, thus increasing mucus flow that can be removed more easily through coughing. Mucolytics break down the chemical structure of
158:
Mucolytics can dissolve thick mucus and are usually used to help relieve respiratory difficulties. They do this by breaking down the chemical bonds between molecules in the mucus. This in turn can lower the viscosity by altering the
147:, to expel or banish) works by signaling the body to increase the amount or hydration of secretions, resulting in more, yet clearer, secretions and lubricating the irritated respiratory tract. One mucoactive agent,
63:. Mucoactive drugs include expectorants, mucolytics, mucoregulators, and mucokinetics. These medications are used in the treatment of respiratory diseases that are complicated by the oversecretion or
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140:
Mucolytics, secretolytics and secretomotorics are different types of medication, yet they are intended to promote drainage of mucus from the lungs.
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427:
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Alternatively, attacking the affinity between secretions and the biological surfaces is another avenue, which is used by
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and muscle-relaxing properties. It is commonly available in cough syrups and also as sustained-release tablets.
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of mucous secretions in the lungs. In turn, the viscosity is dependent upon the concentration of
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Rubin, Bruce K. (2006). "The pharmacologic approach to airway clearance: Mucoactive agents".
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In general, clearance ability is hampered by the bonding to surfaces (stickiness) and by the
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mucus molecules. The mucus becomes thinner and can be removed more easily through coughing.
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Rogers, D. F. (2007). "Mucoactive agents for airway mucus hypersecretory diseases".
105:: increase mucociliary transport (clearance) and transportability of mucus by cough
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86:—include mucolytics, secretolytics and mucokinetics (also called secretomotorics)
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Adams, Michael; Holland, Leland Norman; Bostwick, Paula Manuel (2016).
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Any of these effects could improve airway clearance during coughing.
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43:
are a class of chemical agents that aid in the clearance of
99:: increase airway water or the volume of airway secretions
67:
of mucus. These drugs can be further categorized by their
111:: suppress underlying mechanisms of mucus hypersecretion
479:"Mucolytics, Expectorants, and Mucokinetic Medications"
1090:
458:
Pharmacology for Nurses: A Pathophysiologic
Approach
881:
741:
732:
644:
548:
428:"NCATS Inxight: Drugs – MECYSTEINE HYDROCHLORIDE"
275:Balsamo, R.; Lanata, L.; and Egan, C. G. (2010).
36:Cough medicines usually contain mucoactive agents
51:from the upper and lower airways, including the
165:
460:(5 ed.). Pearson Education. p. 960.
521:
501:National Center for Biotechnology Information
8:
173:Adams, Holland, & Bostwick, 2008, p. 591
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93:: thin (reduce the viscosity of) mucus
7:
408:from the original on 11 August 2020
27:Drugs that clear mucus from airways
25:
343:(9): 1176–93, discussion 1193–7.
1100:
143:An expectorant (from the Latin
477:Rubin, Bruce K (1 July 2007).
364:Paediatric Respiratory Reviews
1:
537:Cough and cold preparations
398:"Definition of Expectorant"
370:(Supplement 1): S215–S219.
281:European Respiratory Review
1144:
376:10.1016/j.prrv.2006.04.198
183:Mucoactive drugs include:
1051:
294:10.1183/09059180.00003510
674:Dembrexine hydrochloride
163:-containing components.
606:Hederae helicis folium
176:
37:
568:Antimony pentasulfide
35:
759:Acetyldihydrocodeine
904:Bibenzonium bromide
137:in the secretions.
75:Mechanism of action
69:mechanism of action
1078:Never to phase III
734:Cough suppressants
277:"Mucoactive drugs"
38:
1088:
1087:
1047:
1046:
583:Guaiacolsulfonate
563:Ammonium chloride
254:Justicia adhatoda
233:potassium citrate
198:ammonium chloride
80:Mucoactive agents
41:Mucoactive agents
16:(Redirected from
1135:
1105:
1104:
1103:
1096:
979:Levodropropizine
838:Levopropoxyphene
784:Dextromethorphan
739:
626:Potassium iodide
530:
523:
516:
507:
490:
483:Respiratory Care
471:
448:
447:
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443:
434:. Archived from
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337:Respiratory Care
332:
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238:potassium iodide
179:Mucoactive drugs
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21:
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1068:Clinical trials
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939:Diphenhydramine
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752:and derivatives
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615:Syrup of ipecac
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404:. 13 May 2016.
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287:(116): 127–33.
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789:Dihydrocodeine
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764:Benzylmorphine
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654:Acetylcysteine
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495:External links
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467:978-0134255163
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438:on 29 May 2019
432:drugs.ncats.io
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243:sodium citrate
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188:acetylcysteine
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109:Mucoregulators
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1029:Prenoxdiazine
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1014:Pentoxyverine
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853:Nicodicodeine
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833:Levomethadone
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826:
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823:Hydromorphone
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799:Ethylmorphine
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669:Carbocisteine
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621:Levoverbenone
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97:Secretolytics
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50:
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19:
1128:Expectorants
949:Droxypropine
944:Dropropizine
924:Cloperastine
894:Benproperine
858:Normethadone
817:+homatropine
813:+guaifenesin
778:+guaifenesin
684:Dornase alfa
600:+oxomemazine
596:+hydrocodone
550:Expectorants
486:
482:
457:
440:. Retrieved
436:the original
431:
422:
410:. Retrieved
392:
367:
363:
357:
340:
336:
284:
280:
270:
252:
213:dornase alfa
182:
166:
157:
144:
142:
139:
128:
125:
114:
108:
103:Mucokinetics
102:
96:
90:
84:expectorants
83:
79:
78:
65:inspissation
40:
39:
29:
18:Mucokinetics
1123:Pulmonology
1064:from market
1024:Piperidione
989:Moguisteine
899:Benzonatate
889:Alloclamide
848:Nicocodeine
809:Hydrocodone
769:Butorphanol
714:Neltenexine
611:Ipecacuanha
588:Guaifenesin
558:Althea root
402:MedicineNet
248:tolu balsam
223:guaifenesin
149:guaifenesin
145:expectorare
135:mucoprotein
121:surfactants
1117:Categories
1034:Tipepidine
1019:Pipazetate
999:Nepinalone
994:Morclofone
984:Meprotixol
974:Isoaminile
964:Gefapixant
919:Clofedanol
914:Clobutinol
909:Butamirate
868:Pholcodine
794:Dimemorfan
745:alkaloids,
699:Letosteine
694:Erdosteine
689:Eprazinone
664:Bromhexine
646:Mucolytics
262:References
228:mecysteine
218:erdosteine
203:bromhexine
153:anxiolytic
91:Mucolytics
1074:Phase III
1062:Withdrawn
1009:Oxolamine
959:Fominoben
954:Fedrilate
863:Noscapine
843:Methadone
724:Stepronin
636:Tyloxapol
412:4 January
131:viscosity
117:abhesives
1107:Medicine
1039:Zipeprol
1004:Oxeladin
969:Glaucine
929:Dibunate
873:Thebacon
828:Laudanum
719:Sobrerol
704:Mannitol
679:Domiodol
659:Ambroxol
592:+codeine
578:Creosote
406:Archived
384:16798570
349:17716385
313:20956181
257:extracts
193:ambroxol
171:—
774:Codeine
748:opioids
573:Cineole
304:9682576
61:trachea
57:bronchi
1093:Portal
1057:WHO-EM
804:Heroin
631:Senega
464:
442:29 May
382:
347:
311:
301:
151:, has
59:, and
49:sputum
882:Other
743:Opium
709:Mesna
161:mucin
53:lungs
45:mucus
489:(7).
462:ISBN
444:2019
414:2018
380:PMID
345:PMID
309:PMID
119:and
541:R05
372:doi
299:PMC
289:doi
47:or
1119::
1070::
815:,
598:,
594:,
487:52
485:.
481:.
430:.
400:.
378:.
366:.
341:52
339:.
321:^
307:.
297:.
285:19
283:.
279:.
123:.
71:.
55:,
1095::
819:)
811:(
780:)
776:(
750:,
617:)
613:(
602:)
590:(
543:)
539:(
529:e
522:t
515:v
470:.
446:.
416:.
386:.
374::
368:7
351:.
315:.
291::
82:—
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
