100:
125:
347:
333:
340:
131:
1020:- as well as in the visual and auditory systems. In these roles, MUC-4 serves to protect and lubricate the epithelium, which facilitates transport and traps foreign particles. One example of its function in the reproductive lining relates to blastocyst implantation resulting from MUC4 downregulation. It is found to be overexpressed during the luteal phase of
922:, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane
1086:
MUC4 is often overexpressed in pancreatic adenocarcinomas and has been shown to promote tumor growth and metastasis, though the mechanism by which it does so is not known. MUC4 detection is emerging as a method to diagnose pancreatic cancer, especially since MUC4 is not detectably expressed in normal
1122:
are thought to contribute to this over-expression of MUC4. By inhibiting MUC-4, scientists have been able to reduce cancer cell proliferation, migration, and tumor size as well as reduce protein S100A4 expression, presenting MUC-4 as a good therapeutic target for the treatment of esophageal cancer.
978:
The large alpha subunit that is glycosylated likely confers the anti-adhesive properties to the cell, allowing for cell–cell and cell–matrix detachment in normal as well as cancerous cells. The heavy glycosylation may also serve as a reservoir for growth factors, which may become released upon
982:
The two subunits of MUC4 are transcribed from a single gene made of 25 exons and with its exon/intron structure identical to that of the mouse gene. Over 24 splice variants have been found for MUC4 using commercial mRNAs or total RNAs extracted from cancer cell lines. Some predicted forms are
1135:
when compared to normal cells. It, however, is found to be overexpressed in lymph node metastases. The initial reduction in MUC-4 appears to promote the transition to the primary tumor, but its subsequent increase in expression facilitate metastasis and ultimately increased malignancy
1228:
Porchet N, Nguyen VC, Dufosse J, Audie JP, Guyonnet-Duperat V, Gross MS, Denis C, Degand P, Bernheim A, Aubert JP (May 1991). "Molecular cloning and chromosomal localization of a novel human tracheo-bronchial mucin cDNA containing tandemly repeated sequences of 48 base pairs".
1193:
ENSG00000145113, ENSG00000273822, ENSG00000278303, ENSG00000273984, ENSG00000276613, ENSG00000277585, ENSG00000275164 GRCh38: Ensembl release 89: ENSG00000278468, ENSG00000145113, ENSG00000273822, ENSG00000278303, ENSG00000273984, ENSG00000276613, ENSG00000277585,
1087:
pancreas and increased expression of MUC-4 suggests a greater progression of the disease. Scientists have recently experimented with MUC4 inhibition in pancreatic cancer using drug delivery methods such as microRNAs. Such efforts have been successful at reducing
926:
found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues.
1950:
Gál E, Veréb Z, Kemény L, et al. Bile accelerates carcinogenic processes in pancreatic ductal adenocarcinoma cells through the overexpression of MUC4. Sci Rep. 2020;10(1):22088. Published 2020 Dec 16. doi:10.1038/s41598-020-79181-6
983:
soluble, while others are membrane bound. However, most of these splice variants are likely artefactual. Many polymorphisms are observed in the tandem repeat region of the alpha subunit, which has a variable number of repeats.
962:
outside the cell. MUC4 mucin consists of a large extracellular alpha subunit that is heavily glycosylated and a beta subunit that is anchored in the cell membrane and extends into the cytosol. This beta subunit is considered an
2061:
Nam KH, Noh TW, Chung SH, Lee SH, Lee MK, Hong SW, Chung WY, Lee EJ, Park CS (July 2011). "Expression of the membrane mucins MUC4 and MUC15, potential markers of malignancy and prognosis, in papillary thyroid carcinoma".
1822:"MUC4/sialomucin complex, the intramembrane ErbB2 ligand, induces specific phosphorylation of ErbB2 and enhances expression of p27(kip), but does not activate mitogen-activated kinase or protein kinaseB/Akt pathways"
1032:, or liver except in abnormal conditions such as cancer. MUC-4, however, may normally be found in bodily fluids like saliva, tears, and milk. In the soluble form, MUC-4 appears to lubricate the epithelial mucosa.
1068:
signaling, and result in its stabilization. As a mucin, MUC-4 also alters adhesive properties of the cell. When overexpressed, the disorganization of mucins may reduce adhesion to other cells as well as the
1113:
MUC4 expression in esophageal cancer often leads to increased tumor proliferation and migration. Like with prostate cancer, increased expression of MUC4 suggests greater development of esophageal cancer.
1144:
MUC4 is found to be overexpressed in papillary thyroid carcinoma, and could serve as a potential marker of malignancy and prognosis. MUC-4 is also found to be a very sensitive and specific marker in
934:, particularly due to its signaling and anti-adhesive properties which contribute to tumor development and metastasis. It is also found to play roles in other diseases such as
2012:"The membrane mucin MUC-4 is elevated in breast tumor lymph node metastases relative to matched primary tumors and confers aggressive properties to breast cancer cells"
138:
2097:
Doyle LA, Möller E, Dal Cin P, Fletcher CD, Mertens F, Hornick JL (May 2011). "MUC-4 is a highly sensitive and specific marker for low-grade fibromyxoid sarcoma".
1422:
Carraway KL, Perez A, Idris N, et al. (2003). "MUC4/sialomucin complex, the intramembrane ErbB2 ligand, in cancer and epithelia: to protect and to survive".
996:
In normal functioning, MUC-4 is known to play anti-adhesive roles in the body, such as in lubricating the reproductive lining. It is also found in the
566:
2010:
Workman HC, Miller JK, Ingalla EQ, Kaur RP, Yamamoto DI, Beckett LA, Young LJ, Cardiff RD, Borowsky AD, Carraway KL, Sweeney C, Carraway KL (2009).
2241:
1156:
MUC-4 is also relevant to several other disease conditions. Polymorphisms in the MUC4 gene have been found to play a role in the progression of
1091:
expression, its downstream signaling, and consequently malignant behavior of the cancer cell such as migration, invasion, and cell detachment.
1210:
2786:
2618:
1962:"The MUC-4 membrane-bound mucin regulates esophageal cancer cell proliferation and migration properties: Implication for S100A4 protein"
837:
967:, whose role in cancer is increasingly being recognized particularly due to its involvement in signalling pathways, particularly with
2658:
1443:
1638:
Gross MS, Guyonnet-Duperat V, Porchet N, et al. (1992). "Mucin 4 (MUC4) gene: regional assignment (3q29) and RFLP analysis".
2508:
1318:
1197:
1119:
2140:
López-Ferrer A, Alameda F, Barranco C, et al. (2001). "MUC-4 expression is increased in dysplastic cervical disorders".
1861:
Chaturvedi P, Singh AP, Chakraborty S, Chauhan SC, Bafna S, Meza JL, Singh PK, Hollingsworth MA, Mehta PP, Batra SK (2008).
1044:
and consequently increasing tumor cell proliferation. The molecular mechanism is thought to be through a MUC-4 complex with
942:. MUC-4 belongs to the human mucin family that is membrane-anchored and can range in molecular weight from 550 to 930
124:
99:
1192:
1145:
57:
2755:
2234:
137:
2745:
1161:
939:
2708:
2668:
130:
2648:
2623:
1271:"MicroRNA-150 directly targets MUC-4 and suppresses growth and malignant behavior of pancreatic cancer cells"
639:
635:
631:
621:
617:
613:
609:
605:
2219:
1523:"Cloning, chromosomal localization and characterization of the murine mucin gene orthologous to human MUC4"
2683:
2227:
1667:"Human mucin gene MUC4: organization of its 5'-region and polymorphism of its central tandem repeat array"
1715:"MUC4 gene polymorphisms associate with endometriosis development and endometriosis-related infertility"
1160:
and related infertility, as well as dysplastic cervical disorders. MUC-4 also has important roles in
1070:
113:
1603:
Desseyn JL, Tetaert S, Gouyer V (December 2007). "Architecture of the large membrane-bound mucins".
44:
2688:
2613:
2500:
2477:
2441:
2413:
1764:
Audie JP, Tetaert D, Pigny P, et al. (1995). "Mucin gene expression in the human endocervix".
789:
744:
2638:
2122:
1989:
1863:"MUC-4 mucin interacts with and stabilizes the HER2 oncoprotein in human pancreatic cancer cells"
1345:
1169:
1001:
73:
1165:
801:
797:
793:
734:
730:
726:
722:
718:
1713:
Chang CY, Chang HW, Chen CM, Lin CY, Chen CP, Lai CH, Lin WY, Liu HP, Sheu JJ, Tsai FJ (2011).
2713:
2542:
2206:
2157:
2114:
2079:
2043:
1981:
1933:
1892:
1843:
1781:
1746:
1692:
1647:
1620:
1585:
1544:
1503:
1449:
1439:
1397:
1300:
1246:
1102:
997:
37:
1052:. The beta subunit of MUC-4 appears to serve as a ligand that causes the phosphorylation of
2628:
2445:
2398:
2196:
2188:
2149:
2106:
2071:
2033:
2023:
1973:
1923:
1882:
1874:
1833:
1773:
1736:
1726:
1682:
1674:
1612:
1575:
1534:
1493:
1483:
1431:
1387:
1379:
1290:
1282:
1238:
943:
346:
332:
217:
148:
1269:
Srivastava SK, Bhardwaj A, Singh S, Arora S, Wang B, Grizzle WE, Singh AP (December 2011).
2791:
2585:
2557:
2473:
1802:
1564:"Genomic organization of MUC4 mucin gene. Towards the characterization of splice variants"
1017:
1009:
339:
192:
69:
1024:. MUC-4 may also have a role in fetal morphogenic development. MUC-4 is not found in the
2735:
2254:
2201:
2176:
2038:
2011:
1887:
1862:
1741:
1714:
1687:
1666:
1498:
1471:
1392:
1367:
1295:
1270:
1098:
1912:"Inhibition of MUC4 expression suppresses pancreatic tumor cell growth and metastasis"
1435:
975:, which is suggested to cause the repression of apoptosis found in many cancer cells.
500:
495:
490:
485:
480:
475:
470:
454:
449:
444:
439:
434:
429:
424:
419:
414:
409:
393:
388:
2780:
2740:
2728:
2408:
2126:
1580:
1563:
1539:
1522:
1242:
1157:
1132:
947:
935:
375:
1993:
2653:
2565:
2432:
2262:
2258:
1088:
1021:
923:
912:
210:
90:
1960:
Bruyère E, Jonckheere N, Frénois F, Mariette C, Van
Seuningen I (September 2011).
1928:
1911:
1878:
2110:
77:
2765:
2760:
2750:
2723:
2693:
2678:
2547:
2403:
2393:
2270:
1961:
1215:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1025:
1977:
1616:
1131:
Unlike pancreatic and esophageal cancers, MUC4 expression is suppressed in the
2593:
1115:
959:
107:
1777:
2703:
2698:
2673:
2663:
2575:
2153:
1286:
1094:
1041:
1013:
530:
310:
231:
176:
163:
65:
2210:
2192:
2161:
2118:
2083:
2047:
1985:
1937:
1896:
1847:
1838:
1821:
1750:
1731:
1624:
1589:
1548:
1507:
1453:
1401:
1304:
2075:
1785:
1696:
1651:
1488:
1383:
1250:
880:
2522:
2517:
2512:
2490:
2485:
2463:
2458:
2418:
1029:
964:
869:
682:
2570:
2453:
2250:
901:
668:
595:
1678:
2643:
2362:
2322:
1049:
931:
850:
552:
2028:
1040:
MUC-4 is thought to play a role in cancer progression by repressing
1910:
Singh AP, Moniaux N, Chauhan SC, Meza JL, Batra SK (January 2004).
2537:
2532:
2377:
2372:
2367:
2357:
2352:
2347:
2327:
2312:
2307:
2292:
2279:
1053:
1045:
972:
968:
919:
898:
1340:
1338:
1336:
1334:
1332:
1330:
1328:
930:
MUC-4 has been found to play various roles in the progression of
515:
511:
2718:
2633:
2527:
2342:
2337:
2332:
2317:
2302:
2297:
2287:
1065:
1057:
1048:
receptors, which alters downstream signaling and down regulates
1005:
908:
61:
2223:
355:
2175:
Shirazi T, Longman RJ, Corfield AP, Probert CS (August 2000).
1350:
Atlas of
Genetics and Cytogenetics in Oncology and Haematology
1061:
1426:. Progress in Nucleic Acid Research and Molecular Biology.
1368:"MUC1 and MUC4: switching the emphasis from large to small"
48:, ASGP, HSA276359, MUC-4, mucin 4, cell surface associated
200:
1797:
1795:
1562:
Escande F, Lemaitre L, Moniaux N, et al. (2002).
1472:"Structure, evolution, and biology of the MUC-4 mucin"
946:
for the actual protein, and up to 4,650 kDa with
911:. Like other mucins, MUC-4 is a high-molecular weight
1319:"Entrez Gene: MUC-4 mucin 4, cell surface associated"
322:
491:
stimulatory C-type lectin receptor signaling pathway
389:
extracellular matrix constituent, lubricant activity
2606:
2584:
2556:
2499:
2472:
2440:
2431:
2386:
2278:
2269:
815:
782:
758:
717:
1665:Nollet S, Moniaux N, Maury J, et al. (1998).
1188:
1186:
1184:
1073:, promoting cancer cell migration and metastasis.
1465:
1463:
1264:
1262:
1260:
958:MUC4 is an O-glycoprotein that can reach up to 2
147:
1820:Jepson S, Komatsu M, Haq B, et al. (2002).
2005:
2003:
1708:
1706:
1470:Chaturvedi P, Singh AP, Batra SK (April 2008).
1361:
1359:
16:Protein-coding gene in the species Homo sapiens
1417:
1415:
1413:
1411:
2235:
8:
1105:cells through increased expression of MUC4.
971:(Her2). This subunit serves as a ligand for
2437:
2275:
2242:
2228:
2220:
714:
600:
526:
481:maintenance of gastrointestinal epithelium
371:
188:
85:
2200:
2037:
2027:
1927:
1886:
1837:
1740:
1730:
1686:
1579:
1538:
1521:Desseyn JL, Clavereau I, Laine A (2002).
1497:
1487:
1391:
1346:"MUC4 (mucin 4, cell surface associated)"
1294:
496:regulation of signaling receptor activity
2548:Structural maintenance of chromosomes 3
2177:"Mucins and inflammatory bowel disease"
1180:
18:
1366:Albrecht H, Carraway KL (June 2011).
430:integral component of plasma membrane
152:
111:
106:
7:
1168:and is found to be overexpressed in
812:
779:
755:
692:
673:
649:
576:
557:
327:
288:
226:
205:
14:
2659:Cholesterylester transfer protein
2509:Chondroitin sulfate proteoglycans
1424:Prog. Nucleic Acid Res. Mol. Biol
904:that in humans is encoded by the
1809:. Weizmann Institute of Science.
1581:10.1046/j.1432-1033.2002.03032.x
1540:10.1046/j.1432-1033.2002.02988.x
1103:pancreatic ductal adenocarcinoma
1064:pathways. MUC-4 may also affect
501:epithelial structure maintenance
345:
338:
331:
136:
129:
123:
98:
1673:. 332. ( Pt 3) (Pt 3): 739–48.
1120:gastroesophageal reflux disease
420:integral component of membrane
356:More reference expression data
311:More reference expression data
242:olfactory zone of nasal mucosa
1:
1966:Biochem. Biophys. Res. Commun
1929:10.1158/0008-5472.CAN-03-2636
1879:10.1158/0008-5472.CAN-07-6041
1436:10.1016/S0079-6603(02)71043-X
1146:low-grade fibromyxoid sarcoma
1097:have been found to stimulate
394:ErbB-2 class receptor binding
121:
2111:10.1097/PAS.0b013e318210c268
1352:. AtlasGeneticsOncology.org.
1243:10.1016/0006-291X(91)91580-6
1056:, but does not activate the
2787:Genes on human chromosome 3
2756:Tumor necrosis factor alpha
2808:
2746:Thyroxine-binding proteins
1978:10.1016/j.bbrc.2011.08.095
1617:10.1016/j.gene.2007.12.014
1372:Cancer Biother. Radiopharm
1231:Biochem Biophys Res Commun
1162:inflammatory bowel disease
940:inflammatory bowel disease
918:The major constituents of
250:mucosa of transverse colon
2709:Serum amyloid P component
2669:Colony-stimulating factor
1211:"Human PubMed Reference:"
884:
879:
875:
868:
849:
838:Chr 3: 195.75 – 195.81 Mb
832:
819:
786:
775:
762:
741:
710:
699:
695:
680:
676:
667:
656:
652:
629:
603:
594:
583:
579:
564:
560:
551:
536:
529:
525:
509:
374:
370:
353:
330:
321:
308:
295:
291:
262:bronchial epithelial cell
258:epithelium of nasopharynx
238:
229:
199:
191:
187:
170:
157:
120:
97:
88:
84:
55:
52:
42:
35:
30:
26:
21:
2649:B-cell activating factor
2624:Alpha 1-antichymotrypsin
2154:10.1053/hupa.2001.28938
266:mucosa of sigmoid colon
2684:Membrane glycoproteins
2193:10.1136/pmj.76.898.473
1839:10.1038/sj.onc.1205970
1778:10.1093/humrep/10.1.98
1732:10.1186/1741-7015-9-19
1152:Role in other diseases
1000:- particularly in the
2076:10.1089/thy.2010.0339
1489:10.1096/fj.07-9673rev
1384:10.1089/cbr.2011.1017
1287:10.1093/carcin/bgr223
435:extracellular exosome
254:palpebral conjunctiva
1071:extracellular matrix
471:cell-matrix adhesion
455:extracellular matrix
415:extracellular region
114:Chromosome 3 (human)
2689:Myelin protein zero
2614:Activin and inhibin
2414:Phytohaemagglutinin
2099:Am. J. Surg. Pathol
486:O-glycan processing
445:extracellular space
2639:Asialoglycoprotein
1170:ulcerative colitis
464:Biological process
403:Cellular component
382:Molecular function
2774:
2773:
2714:Sialoglycoprotein
2602:
2601:
2543:Platelet factor 4
2427:
2426:
2016:Breast Cancer Res
1679:10.1042/bj3320739
998:respiratory tract
892:
891:
888:
887:
864:
863:
828:
827:
809:
808:
771:
770:
752:
751:
706:
705:
689:
688:
663:
662:
646:
645:
590:
589:
573:
572:
521:
520:
366:
365:
362:
361:
317:
316:
304:
303:
285:
284:
270:mucosa of pharynx
183:
182:
2799:
2629:Apolipoprotein H
2438:
2399:Intrinsic factor
2276:
2244:
2237:
2230:
2221:
2215:
2214:
2204:
2172:
2166:
2165:
2148:(11): 1197–202.
2137:
2131:
2130:
2094:
2088:
2087:
2058:
2052:
2051:
2041:
2031:
2007:
1998:
1997:
1957:
1951:
1948:
1942:
1941:
1931:
1907:
1901:
1900:
1890:
1858:
1852:
1851:
1841:
1817:
1811:
1810:
1799:
1790:
1789:
1761:
1755:
1754:
1744:
1734:
1710:
1701:
1700:
1690:
1662:
1656:
1655:
1635:
1629:
1628:
1600:
1594:
1593:
1583:
1559:
1553:
1552:
1542:
1518:
1512:
1511:
1501:
1491:
1467:
1458:
1457:
1419:
1406:
1405:
1395:
1363:
1354:
1353:
1342:
1323:
1322:
1315:
1309:
1308:
1298:
1266:
1255:
1254:
1225:
1219:
1218:
1207:
1201:
1190:
877:
876:
860:
845:
840:
823:
813:
804:
780:
776:RefSeq (protein)
766:
756:
747:
715:
693:
674:
650:
625:
601:
577:
558:
527:
372:
358:
349:
342:
335:
328:
313:
289:
246:nasal epithelium
234:
232:Top expressed in
227:
206:
189:
179:
166:
155:
140:
133:
127:
116:
102:
86:
80:
78:MUC4 - orthologs
47:
40:
19:
2807:
2806:
2802:
2801:
2800:
2798:
2797:
2796:
2777:
2776:
2775:
2770:
2598:
2580:
2552:
2495:
2468:
2423:
2382:
2265:
2248:
2218:
2174:
2173:
2169:
2139:
2138:
2134:
2096:
2095:
2091:
2060:
2059:
2055:
2029:10.1186/bcr2364
2009:
2008:
2001:
1959:
1958:
1954:
1949:
1945:
1909:
1908:
1904:
1860:
1859:
1855:
1832:(49): 7524–32.
1819:
1818:
1814:
1801:
1800:
1793:
1763:
1762:
1758:
1712:
1711:
1704:
1664:
1663:
1659:
1637:
1636:
1632:
1602:
1601:
1597:
1574:(15): 3637–44.
1568:Eur. J. Biochem
1561:
1560:
1556:
1527:Eur. J. Biochem
1520:
1519:
1515:
1469:
1468:
1461:
1446:
1421:
1420:
1409:
1365:
1364:
1357:
1344:
1343:
1326:
1317:
1316:
1312:
1268:
1267:
1258:
1227:
1226:
1222:
1209:
1208:
1204:
1194:ENSG00000275164
1191:
1182:
1178:
1166:Crohn's disease
1154:
1142:
1129:
1111:
1084:
1079:
1038:
1010:digestive tract
994:
989:
956:
881:View/Edit Human
858:
843:
836:
833:Location (UCSC)
821:
800:
796:
792:
788:
764:
743:
737:
733:
729:
725:
721:
640:ENSG00000275164
638:
636:ENSG00000277585
634:
632:ENSG00000276613
624:
622:ENSG00000273984
620:
618:ENSG00000278303
616:
614:ENSG00000273822
612:
610:ENSG00000145113
608:
606:ENSG00000278468
604:
505:
459:
450:plasma membrane
398:
354:
344:
343:
337:
336:
309:
300:
281:
276:
272:
268:
264:
260:
256:
252:
248:
244:
230:
174:
161:
153:
143:
142:
141:
134:
112:
89:Gene location (
56:
43:
36:
17:
12:
11:
5:
2805:
2803:
2795:
2794:
2789:
2779:
2778:
2772:
2771:
2769:
2768:
2763:
2758:
2753:
2748:
2743:
2738:
2736:Thrombopoietin
2733:
2732:
2731:
2726:
2721:
2711:
2706:
2701:
2696:
2691:
2686:
2681:
2676:
2671:
2666:
2661:
2656:
2651:
2646:
2641:
2636:
2631:
2626:
2621:
2616:
2610:
2608:
2604:
2603:
2600:
2599:
2597:
2596:
2590:
2588:
2582:
2581:
2579:
2578:
2573:
2568:
2562:
2560:
2554:
2553:
2551:
2550:
2545:
2540:
2535:
2530:
2525:
2520:
2515:
2505:
2503:
2497:
2496:
2494:
2493:
2488:
2482:
2480:
2470:
2469:
2467:
2466:
2461:
2456:
2450:
2448:
2435:
2429:
2428:
2425:
2424:
2422:
2421:
2416:
2411:
2406:
2401:
2396:
2390:
2388:
2384:
2383:
2381:
2380:
2375:
2370:
2365:
2360:
2355:
2350:
2345:
2340:
2335:
2330:
2325:
2320:
2315:
2310:
2305:
2300:
2295:
2290:
2284:
2282:
2273:
2267:
2266:
2255:glycoconjugate
2249:
2247:
2246:
2239:
2232:
2224:
2217:
2216:
2187:(898): 473–8.
2181:Postgrad Med J
2167:
2132:
2089:
2053:
1999:
1952:
1943:
1902:
1873:(7): 2065–70.
1853:
1812:
1791:
1756:
1702:
1657:
1630:
1611:(2): 215–222.
1595:
1554:
1533:(13): 3150–9.
1513:
1459:
1444:
1407:
1355:
1324:
1310:
1281:(12): 1832–9.
1275:Carcinogenesis
1256:
1220:
1202:
1179:
1177:
1174:
1153:
1150:
1141:
1138:
1128:
1125:
1110:
1107:
1099:carcinogenesis
1083:
1080:
1078:
1077:Role in cancer
1075:
1037:
1034:
993:
990:
988:
985:
955:
952:
890:
889:
886:
885:
883:
873:
872:
866:
865:
862:
861:
856:
854:
847:
846:
841:
834:
830:
829:
826:
825:
817:
816:
810:
807:
806:
784:
783:
777:
773:
772:
769:
768:
760:
759:
753:
750:
749:
739:
738:
712:
708:
707:
704:
703:
697:
696:
690:
687:
686:
678:
677:
671:
665:
664:
661:
660:
654:
653:
647:
644:
643:
627:
626:
598:
592:
591:
588:
587:
581:
580:
574:
571:
570:
562:
561:
555:
549:
548:
543:
538:
534:
533:
523:
522:
519:
518:
507:
506:
504:
503:
498:
493:
488:
483:
478:
473:
467:
465:
461:
460:
458:
457:
452:
447:
442:
437:
432:
427:
422:
417:
412:
406:
404:
400:
399:
397:
396:
391:
385:
383:
379:
378:
368:
367:
364:
363:
360:
359:
351:
350:
325:
319:
318:
315:
314:
306:
305:
302:
301:
299:
296:
293:
292:
286:
283:
282:
280:
279:
275:
271:
267:
263:
259:
255:
251:
247:
243:
239:
236:
235:
223:
222:
214:
203:
197:
196:
193:RNA expression
185:
184:
181:
180:
172:
168:
167:
159:
156:
151:
145:
144:
135:
128:
122:
118:
117:
110:
104:
103:
95:
94:
82:
81:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
2804:
2793:
2790:
2788:
2785:
2784:
2782:
2767:
2764:
2762:
2759:
2757:
2754:
2752:
2749:
2747:
2744:
2742:
2741:Thyroglobulin
2739:
2737:
2734:
2730:
2729:Glycophorin C
2727:
2725:
2722:
2720:
2717:
2716:
2715:
2712:
2710:
2707:
2705:
2702:
2700:
2697:
2695:
2692:
2690:
2687:
2685:
2682:
2680:
2677:
2675:
2672:
2670:
2667:
2665:
2662:
2660:
2657:
2655:
2652:
2650:
2647:
2645:
2642:
2640:
2637:
2635:
2632:
2630:
2627:
2625:
2622:
2620:
2617:
2615:
2612:
2611:
2609:
2605:
2595:
2592:
2591:
2589:
2587:
2583:
2577:
2574:
2572:
2569:
2567:
2564:
2563:
2561:
2559:
2555:
2549:
2546:
2544:
2541:
2539:
2536:
2534:
2531:
2529:
2526:
2524:
2521:
2519:
2516:
2514:
2510:
2507:
2506:
2504:
2502:
2498:
2492:
2489:
2487:
2484:
2483:
2481:
2479:
2475:
2471:
2465:
2462:
2460:
2457:
2455:
2452:
2451:
2449:
2447:
2443:
2439:
2436:
2434:
2433:Proteoglycans
2430:
2420:
2417:
2415:
2412:
2410:
2409:Peptidoglycan
2407:
2405:
2402:
2400:
2397:
2395:
2392:
2391:
2389:
2385:
2379:
2376:
2374:
2371:
2369:
2366:
2364:
2361:
2359:
2356:
2354:
2351:
2349:
2346:
2344:
2341:
2339:
2336:
2334:
2331:
2329:
2326:
2324:
2321:
2319:
2316:
2314:
2311:
2309:
2306:
2304:
2301:
2299:
2296:
2294:
2291:
2289:
2286:
2285:
2283:
2281:
2277:
2274:
2272:
2268:
2264:
2263:glycopeptides
2260:
2259:glycoproteins
2256:
2252:
2245:
2240:
2238:
2233:
2231:
2226:
2225:
2222:
2212:
2208:
2203:
2198:
2194:
2190:
2186:
2182:
2178:
2171:
2168:
2163:
2159:
2155:
2151:
2147:
2143:
2136:
2133:
2128:
2124:
2120:
2116:
2112:
2108:
2105:(5): 733–41.
2104:
2100:
2093:
2090:
2085:
2081:
2077:
2073:
2070:(7): 745–50.
2069:
2065:
2057:
2054:
2049:
2045:
2040:
2035:
2030:
2025:
2021:
2017:
2013:
2006:
2004:
2000:
1995:
1991:
1987:
1983:
1979:
1975:
1971:
1967:
1963:
1956:
1953:
1947:
1944:
1939:
1935:
1930:
1925:
1922:(2): 622–30.
1921:
1917:
1913:
1906:
1903:
1898:
1894:
1889:
1884:
1880:
1876:
1872:
1868:
1864:
1857:
1854:
1849:
1845:
1840:
1835:
1831:
1827:
1823:
1816:
1813:
1808:
1804:
1798:
1796:
1792:
1787:
1783:
1779:
1775:
1772:(1): 98–102.
1771:
1767:
1760:
1757:
1752:
1748:
1743:
1738:
1733:
1728:
1724:
1720:
1716:
1709:
1707:
1703:
1698:
1694:
1689:
1684:
1680:
1676:
1672:
1668:
1661:
1658:
1653:
1649:
1645:
1641:
1634:
1631:
1626:
1622:
1618:
1614:
1610:
1606:
1599:
1596:
1591:
1587:
1582:
1577:
1573:
1569:
1565:
1558:
1555:
1550:
1546:
1541:
1536:
1532:
1528:
1524:
1517:
1514:
1509:
1505:
1500:
1495:
1490:
1485:
1482:(4): 966–81.
1481:
1477:
1473:
1466:
1464:
1460:
1455:
1451:
1447:
1445:9780125400718
1441:
1437:
1433:
1429:
1425:
1418:
1416:
1414:
1412:
1408:
1403:
1399:
1394:
1389:
1385:
1381:
1378:(3): 261–71.
1377:
1373:
1369:
1362:
1360:
1356:
1351:
1347:
1341:
1339:
1337:
1335:
1333:
1331:
1329:
1325:
1320:
1314:
1311:
1306:
1302:
1297:
1292:
1288:
1284:
1280:
1276:
1272:
1265:
1263:
1261:
1257:
1252:
1248:
1244:
1240:
1237:(2): 414–22.
1236:
1232:
1224:
1221:
1216:
1212:
1206:
1203:
1199:
1195:
1189:
1187:
1185:
1181:
1175:
1173:
1171:
1167:
1163:
1159:
1158:endometriosis
1151:
1149:
1147:
1139:
1137:
1134:
1133:primary tumor
1126:
1124:
1121:
1117:
1108:
1106:
1104:
1100:
1096:
1092:
1090:
1081:
1076:
1074:
1072:
1067:
1063:
1059:
1055:
1051:
1047:
1043:
1035:
1033:
1031:
1027:
1023:
1019:
1015:
1011:
1007:
1003:
999:
991:
986:
984:
980:
979:degradation.
976:
974:
970:
966:
961:
953:
951:
949:
948:glycosylation
945:
941:
937:
936:endometriosis
933:
928:
925:
921:
916:
914:
910:
907:
903:
900:
897:(MUC-4) is a
896:
882:
878:
874:
871:
867:
857:
855:
852:
848:
842:
839:
835:
831:
824:
818:
814:
811:
805:
803:
799:
795:
791:
785:
781:
778:
774:
767:
761:
757:
754:
748:
746:
740:
736:
732:
728:
724:
720:
716:
713:
711:RefSeq (mRNA)
709:
702:
698:
694:
691:
685:
684:
679:
675:
672:
670:
666:
659:
655:
651:
648:
642:
641:
637:
633:
628:
623:
619:
615:
611:
607:
602:
599:
597:
593:
586:
582:
578:
575:
569:
568:
563:
559:
556:
554:
550:
547:
544:
542:
539:
535:
532:
528:
524:
517:
513:
508:
502:
499:
497:
494:
492:
489:
487:
484:
482:
479:
477:
476:cell adhesion
474:
472:
469:
468:
466:
463:
462:
456:
453:
451:
448:
446:
443:
441:
438:
436:
433:
431:
428:
426:
423:
421:
418:
416:
413:
411:
408:
407:
405:
402:
401:
395:
392:
390:
387:
386:
384:
381:
380:
377:
376:Gene ontology
373:
369:
357:
352:
348:
341:
334:
329:
326:
324:
320:
312:
307:
297:
294:
290:
287:
277:
273:
269:
265:
261:
257:
253:
249:
245:
241:
240:
237:
233:
228:
225:
224:
221:
219:
215:
213:
212:
208:
207:
204:
202:
198:
194:
190:
186:
178:
173:
169:
165:
160:
150:
146:
139:
132:
126:
119:
115:
109:
105:
101:
96:
92:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
2654:4-1BB ligand
2566:Fibromodulin
2271:Mucoproteins
2184:
2180:
2170:
2145:
2141:
2135:
2102:
2098:
2092:
2067:
2063:
2056:
2019:
2015:
1972:(2): 325–9.
1969:
1965:
1955:
1946:
1919:
1915:
1905:
1870:
1866:
1856:
1829:
1825:
1815:
1806:
1769:
1765:
1759:
1722:
1718:
1670:
1660:
1643:
1639:
1633:
1608:
1604:
1598:
1571:
1567:
1557:
1530:
1526:
1516:
1479:
1475:
1427:
1423:
1375:
1371:
1349:
1313:
1278:
1274:
1234:
1230:
1223:
1214:
1205:
1155:
1143:
1130:
1112:
1093:
1089:EGF receptor
1085:
1039:
1022:menstruation
995:
981:
977:
957:
929:
924:glycoprotein
917:
913:glycoprotein
905:
894:
893:
820:
790:NP_001309397
787:
763:
745:NM_001322468
742:
700:
681:
657:
630:
584:
565:
545:
540:
216:
209:
175:195,811,973
162:195,746,765
53:External IDs
2766:Vitronectin
2761:Uteroglobin
2751:Transcortin
2724:Glycophorin
2694:Osteonectin
2679:Lactoferrin
2404:Orosomucoid
2394:Haptoglobin
2142:Hum. Pathol
1803:"MUC4 Gene"
1766:Hum. Reprod
1646:(1): 21–6.
1118:present in
1026:gallbladder
960:micrometers
410:Golgi lumen
31:Identifiers
2781:Categories
2594:Syndecan 1
2022:(5): R70.
1916:Cancer Res
1867:Cancer Res
1671:Biochem. J
1640:Ann. Genet
1430:: 149–85.
1200:, May 2017
1176:References
1116:Bile acids
1109:Esophageal
1095:Bile acids
1082:Pancreatic
1008:- and the
220:(ortholog)
2704:Protein S
2699:Protein C
2674:Hemopexin
2664:Clusterin
2576:Keratocan
2127:205920712
1807:GeneCards
1042:apoptosis
1014:esophagus
1012:- in the
954:Structure
802:NP_612154
798:NP_060876
794:NP_004523
735:NM_138298
731:NM_138297
727:NM_018406
723:NM_004532
719:NM_138299
531:Orthologs
66:GeneCards
2523:Brevican
2518:Neurocan
2513:Aggrecan
2491:Perlecan
2486:Testican
2464:Versican
2459:Biglycan
2419:Ovomucin
2211:10908374
2162:11727258
2119:21415703
2084:21615302
2048:19761616
1994:25816150
1986:21889495
1938:14744777
1897:18381409
1848:12386815
1826:Oncogene
1751:21349170
1625:18242885
1590:12153560
1549:12084055
1508:18024835
1454:12102554
1402:21728842
1305:21983127
1196:–
1164:such as
1030:pancreas
987:Function
965:oncogene
870:Wikidata
510:Sources:
440:membrane
2571:Lumican
2454:Decorin
2251:Protein
2202:1741691
2064:Thyroid
2039:2790847
1888:2835497
1786:7745080
1742:3052195
1719:BMC Med
1697:9620877
1688:1219535
1652:1351710
1499:2835492
1476:FASEB J
1393:3128783
1296:3220613
1251:1673336
1198:Ensembl
1036:Disease
1002:trachea
902:protein
895:Mucin-4
669:UniProt
596:Ensembl
537:Species
516:QuickGO
425:vesicle
274:urethra
195:pattern
38:Aliases
2792:Mucins
2644:Avidin
2323:MUC5AC
2209:
2199:
2160:
2125:
2117:
2082:
2046:
2036:
1992:
1984:
1936:
1895:
1885:
1846:
1784:
1749:
1739:
1725:: 19.
1695:
1685:
1650:
1623:
1588:
1547:
1506:
1496:
1452:
1442:
1400:
1390:
1303:
1293:
1249:
1127:Breast
1050:CDKN1B
992:Normal
932:cancer
853:search
851:PubMed
683:Q99102
553:Entrez
323:BioGPS
278:rectum
62:158372
2607:Other
2538:CSPG5
2533:CSPG4
2387:Other
2378:MUC20
2373:MUC19
2368:MUC17
2363:MUC16
2358:MUC15
2353:MUC13
2348:MUC12
2328:MUC5B
2313:MUC3B
2308:MUC3A
2293:CD164
2280:Mucin
2123:S2CID
1990:S2CID
1140:Other
1054:ErbB2
1046:ERBB2
1018:colon
973:ErbB2
969:ErbB2
920:mucus
899:mucin
546:Mouse
541:Human
512:Amigo
218:Mouse
211:Human
158:Start
91:Human
2719:CD43
2634:CD70
2619:ADAM
2528:CD44
2343:MUC8
2338:MUC7
2333:MUC6
2318:MUC4
2303:MUC2
2298:MUC1
2288:CD43
2261:and
2207:PMID
2158:PMID
2115:PMID
2080:PMID
2044:PMID
1982:PMID
1934:PMID
1893:PMID
1844:PMID
1782:PMID
1747:PMID
1693:PMID
1648:PMID
1621:PMID
1605:Gene
1586:PMID
1545:PMID
1504:PMID
1450:PMID
1440:ISBN
1398:PMID
1301:PMID
1247:PMID
1066:HER2
1058:MAPK
1016:and
1006:lung
1004:and
938:and
909:gene
906:MUC4
567:4585
201:Bgee
154:3q29
149:Band
108:Chr.
70:MUC4
58:OMIM
45:MUC4
22:MUC4
2197:PMC
2189:doi
2150:doi
2107:doi
2072:doi
2034:PMC
2024:doi
1974:doi
1970:413
1924:doi
1883:PMC
1875:doi
1834:doi
1774:doi
1737:PMC
1727:doi
1683:PMC
1675:doi
1613:doi
1609:410
1576:doi
1572:269
1535:doi
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