547:
524:
51:
42:
2519:
858:
states: "Guaiacum has a local stimulant action which is sometimes useful in sore throat. The resin is used in chronic gout and rheumatism, whilst the wood is an ingredient in the compound concentrated solution of
728:
Side effects may include dizziness, sleepiness, skin rash, and nausea. While it has not been properly studied in pregnancy, it appears to be safe. It is believed to work by making airway secretions more liquid.
1944:
208:
725:. It may be used in combination with other medications. A 2014 study found that guaifenesin has no effect on sputum production or clearance in upper respiratory infections.
1294:
2539:
1634:
1465:
132:
848:; it was soon brought back to Europe, where it acquired an immense reputation in the sixteenth century as a cure for syphilis and certain other diseases..."
636:
882:
guaifenesin to stop marketing their unapproved versions, leaving Adams
Respiratory Therapeutics in control of the market. In 2007, Adams was acquired by
775:
assessing guaifenesin for the treatment of acute cough, with one finding significant benefit and the other two trials finding that it was not effective.
967:, since guaifenesin does not provide analgesia or produce unconsciousness. In horses, the drug's biological half-life is 77 minutes. Premedication with
1937:
878:
for the extended-release version, which received approval on 12 July 2002. Because of this, the FDA then issued letters to other manufacturers of
903:, and is supplied as a tablet, a capsule, an extended-release (long-acting) tablet, dissolving granules, and a syrup. It is available under many
1187:
The
Complete Guide to Medications During Pregnancy and Breastfeeding: Everything You Need to Know to Make the Best Choices for You and Your Baby
2473:
1888:
1035:
Aluri JB, Stavchansky S (1993). "Determination of guaifenesin in human plasma by liquid chromatography in the presence of pseudoephedrine".
1930:
1848:
1627:
820:. It may aid in the flow of respiratory tract secretions, allowing ciliary movement to carry the loosened secretions upward toward the
2559:
1223:
1196:
656:
1103:"Guaifenesin has no effect on sputum volume or sputum properties in adolescents and adults with acute respiratory tract infections"
1517:
317:
248:
164:
1620:
1247:
740:. In 2021, it was the 288th most commonly prescribed medication in the United States, with more than 600,000 prescriptions.
2289:
2509:
1469:
812:
Guaifenesin is thought to act as an expectorant by increasing the volume and reducing the viscosity of secretions in the
867:
443:
183:
2490:
1905:
503:
1599:
1742:
871:
1492:
860:
2554:
2549:
959:
Guaifenesin's neurological properties first became known in the late 1940s. Guaifenesin is a centrally acting
610:
2090:
951:
In 2014, sales of guaifenesin were estimated to be approximately $ 135 million per year in the United States.
392:
1439:
2478:
2233:
2229:
2016:
2012:
1893:
194:
542:
2027:
963:
used routinely in large-animal veterinary surgery. Guaifenesin is used in combination with, for example,
1007:"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)"
2544:
1984:
737:
621:
383:
971:(1.1 mg/kg) can reduce the dose required from 163 mg/kg (in geldings) to just 88 mg/kg.
492:
2175:
1006:
875:
296:
748:
Guaifenesin is used to try to help with coughing up thick mucus, and is sometimes combined with the
2320:
2194:
2008:
900:
519:
338:
201:
50:
1604:
1407:
Gutierrez, K. (2007). Pharmacotherapeutics: Clinical
Reasoning in Primary Care. W.B. Saunders Co.
1386:
1310:"Over-the-counter (OTC) medications for acute cough in children and adults in community settings"
915:. Drugs combined with guaifenesin in over-the-counter preparations include the cough-suppressant
733:
2150:
1999:
1979:
1819:
1577:
1339:
1219:
1213:
1192:
1162:
1124:
1052:
908:
904:
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710:
114:
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1329:
1321:
1185:
1154:
1114:
1044:
916:
912:
753:
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559:
276:
68:
452:
2523:
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2031:
1974:
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1357:
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626:
432:
284:
231:
546:
523:
347:
2484:
2205:
2180:
2070:
1953:
1899:
1687:
1677:
1542:
Tranquilli WJ, Thurmon JC, Grimm KA, eds. (2007). "Centrally Acting Muscle
Relaxants".
1334:
1309:
772:
1560:
Valverde A (April 2013). "Balanced anesthesia and constant-rate infusions in horses".
1145:
O'Connell OJ (May 2014). "Is extended-release guaifenesin no better than a placebo?".
988:
840:
were in use as a generic remedy by
American indigenous peoples when explorers reached
2533:
2445:
2430:
2350:
2269:
2249:
2239:
2215:
2085:
2037:
1864:
1682:
1422:
1048:
940:
928:
886:. The drug is now sold over-the-counter by many companies, alone and in combination.
854:
841:
535:
263:
156:
1922:
2365:
2360:
2340:
2310:
2274:
2100:
2022:
1957:
1805:
1708:
1648:
1325:
1269:
1079:
825:
226:
221:
216:
142:
1239:
372:
2440:
2405:
2315:
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2264:
2225:
2185:
2130:
1873:
1868:
1794:
1759:
1713:
924:
844:
in the 16th century. The
Spanish encountered guaiacum wood "when they conquered
784:
749:
150:
1573:
2450:
2435:
2415:
2410:
2400:
2390:
2380:
2335:
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2284:
2210:
2115:
2110:
2105:
2080:
1843:
1827:
1785:
1769:
1764:
1703:
1672:
1657:
920:
845:
732:
Guaifenesin has been used medically since at least 1933. It is available as a
702:
586:
423:
664:
InChI=1S/C10H14O4/c1-13-9-4-2-3-5-10(9)14-7-8(12)6-11/h2-5,8,11-12H,6-7H2,1H3
2425:
2375:
2370:
2279:
2259:
2140:
2052:
1859:
1723:
1612:
932:
757:
136:
33:
1581:
1343:
1166:
1158:
1128:
1119:
1102:
1082:. Drugs.com, American Society of Health-System Pharmacists. 23 January 2023
1389:. MedlinePlus, United States National Library of Medicine. 15 January 2022
1056:
2455:
2420:
2385:
2345:
2244:
2135:
2120:
2095:
2075:
1994:
1799:
1790:
1728:
968:
964:
837:
817:
796:
722:
718:
403:
178:
412:
41:
2190:
1989:
1854:
821:
813:
358:
17:
2220:
2164:
792:
761:
706:
483:
289:
756:, such as in Mucinex DM or Robitussin DM. It is also combined with
472:
2159:
2125:
714:
609:
600:
1644:
463:
1926:
1616:
863:, which was formerly much used as an alternative in syphilis."
257:
173:
1014:
1101:
Hoffer-Schaefer A, Rozycki HJ, Yopp MA, Rubin BK (May 2014).
760:
in
Primatene and Bronkaid tablets for symptomatic relief of
508:
86:
77:
1440:"Drug Approval Package: Mucinex (Guaifenesin) NDA #21-282"
98:
92:
71:
681:
1518:"Guaifenesin (Oral Route) Description and Brand Names"
2507:
101:
95:
89:
83:
74:
2298:
2158:
2149:
2061:
1965:
1836:
1818:
1778:
1750:
1741:
1696:
1665:
1656:
1544:
Lumb and Jones' Veterinary
Anesthesia and Analgesia
705:taken by mouth and marketed as an aid to eliminate
620:
598:
585:
558:
553:
534:
502:
482:
462:
442:
422:
402:
391:
382:
357:
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275:
247:
242:
207:
193:
163:
149:
131:
123:
113:
80:
62:
57:
1421:
1184:
866:In the US, guaifenesin was first approved by the
1308:Smith SM, Schroeder K, Fahey T (November 2014).
874:" in its original approval, the drug received a
371:
346:
1140:
1138:
824:. Thus, it may increase the efficiency of the
1938:
1628:
1466:"Announcements RB Press release - 10/12/2007"
1415:
1413:
8:
182:
32:
870:(FDA) in 1952. Although previously deemed "
230:
2155:
1945:
1931:
1923:
1747:
1662:
1635:
1621:
1613:
1080:"Guaifenesin: Monograph for Professionals"
828:and facilitate removal of the secretions.
545:
522:
431:
1333:
1178:
1176:
1118:
451:
1555:
1553:
1215:Veterinary Pharmacology and Therapeutics
2540:Drugs with unknown mechanisms of action
2514:
1493:"FDA Bumps Phlegm-Fighters From Market"
1074:
1072:
1070:
1068:
1066:
980:
661:
641:
518:
411:
322:
155:
1600:"F.D.A. Study Worries Makers of Drugs"
1381:
1379:
1377:
1375:
1218:. John Wiley & Sons. p. 287.
989:"Guaifenesin Definition & Meaning"
536:
329:)-3-(2-methoxyphenoxy)propane-1,2-diol
31:
1546:(2nd ed.). Blackwell Publishing.
1270:"Guaifenesin – Drug Usage Statistics"
1191:. St. Martin's Press. p. PT282.
491:
141:
7:
1250:from the original on 15 January 2024
220:
836:Similar medicines derived from the
783:Although generally well-tolerated,
471:
362:
25:
2517:
570:
67:
49:
40:
669:Key:HSRJKNPTNIJEKV-UHFFFAOYSA-N
1562:Vet Clin North Am Equine Pract
1326:10.1002/14651858.CD001831.pub5
1212:Riviere JE, Papich MG (2013).
787:of guaifenesin may include an
576:
564:
1:
1049:10.1016/0731-7085(93)80072-9
868:Food and Drug Administration
1954:Cough and cold preparations
1743:Xanthine oxidase inhibitors
1491:Goldstein J (25 May 2007).
2576:
1574:10.1016/j.cveq.2012.11.004
1358:"Guaifenesin Side Effects"
1314:Cochrane Database Syst Rev
1183:Weiner CP, Rope K (2013).
872:Generally Regarded as Safe
554:Chemical and physical data
2560:2-Methoxyphenyl compounds
2468:
1883:
1424:Textbook of Pharmacognosy
799:, dizziness or headache.
677:
652:
632:
313:
48:
39:
2091:Dembrexine hydrochloride
1360:. Drugs.com. 3 July 2023
851:The 1955 edition of the
1497:The Wall Street Journal
713:. Chemically, it is an
268:OTC / Rx-only
2023:Hederae helicis folium
1159:10.4187/respcare.03319
1120:10.4187/respcare.02640
27:Expectorant medication
1985:Antimony pentasulfide
1240:"The Top 300 of 2021"
907:, as either the sole
2176:Acetyldihydrocodeine
927:/acetaminophen, and
876:New Drug Application
752:(cough suppressant)
696:glyceryl guaiacolate
644:O(c1ccccc1OC)CC(O)CO
127:Glyceryl guaiacolate
2321:Bibenzonium bromide
1037:J Pharm Biomed Anal
890:Society and culture
808:Mechanism of action
36:
2495:Never to phase III
2151:Cough suppressants
1910:Never to phase III
1820:Mitotic inhibitors
1608:. 20 October 1981.
1605:The New York Times
1446:. 25 November 2002
1444:accessdata.fda.gov
1420:Wallis TE (1955).
734:generic medication
2505:
2504:
2464:
2463:
2000:Guaiacolsulfonate
1980:Ammonium chloride
1920:
1919:
1814:
1813:
1737:
1736:
909:active ingredient
884:Reckitt Benckiser
789:allergic reaction
771:identified three
711:respiratory tract
689:
688:
611:Interactive image
504:CompTox Dashboard
261:
176:
16:(Redirected from
2567:
2522:
2521:
2520:
2513:
2396:Levodropropizine
2255:Levopropoxyphene
2201:Dextromethorphan
2156:
2043:Potassium iodide
1947:
1940:
1933:
1924:
1752:purine analogues
1748:
1663:
1637:
1630:
1623:
1614:
1609:
1586:
1585:
1557:
1548:
1547:
1539:
1533:
1532:
1530:
1528:
1514:
1508:
1507:
1505:
1503:
1488:
1482:
1481:
1479:
1477:
1468:. Archived from
1462:
1456:
1455:
1453:
1451:
1436:
1430:
1429:
1427:
1417:
1408:
1405:
1399:
1398:
1396:
1394:
1383:
1370:
1369:
1367:
1365:
1354:
1348:
1347:
1337:
1320:(11): CD001831.
1305:
1299:
1298:
1295:"Guaifenesin DM"
1291:
1285:
1284:
1282:
1280:
1266:
1260:
1259:
1257:
1255:
1236:
1230:
1229:
1209:
1203:
1202:
1190:
1180:
1171:
1170:
1142:
1133:
1132:
1122:
1107:Respiratory Care
1098:
1092:
1091:
1089:
1087:
1076:
1061:
1060:
1032:
1026:
1025:
1023:
1021:
1011:nctr-crs.fda.gov
1003:
997:
996:
985:
917:dextromethorphan
913:combination drug
754:dextromethorphan
738:over the counter
694:, also known as
685:
684:
613:
593:
578:
572:
566:
549:
538:
527:
526:
512:
510:
495:
475:
455:
435:
415:
395:
375:
365:
364:
350:
300:
266:
259:
256:
234:
224:
186:
175:
172:
159:
145:
108:
107:
104:
103:
100:
97:
94:
91:
88:
85:
82:
79:
76:
73:
53:
44:
37:
35:
21:
2575:
2574:
2570:
2569:
2568:
2566:
2565:
2564:
2555:Glycerol ethers
2550:Catechol ethers
2530:
2529:
2528:
2518:
2516:
2508:
2506:
2501:
2500:
2485:Clinical trials
2460:
2356:Diphenhydramine
2294:
2169:and derivatives
2168:
2163:
2145:
2057:
2032:Syrup of ipecac
1961:
1951:
1921:
1916:
1915:
1900:Clinical trials
1879:
1832:
1810:
1774:
1733:
1692:
1652:
1643:Drugs used for
1641:
1598:
1595:
1590:
1589:
1559:
1558:
1551:
1541:
1540:
1536:
1526:
1524:
1516:
1515:
1511:
1501:
1499:
1490:
1489:
1485:
1475:
1473:
1472:on 15 July 2011
1464:
1463:
1459:
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1447:
1438:
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1419:
1418:
1411:
1406:
1402:
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1307:
1306:
1302:
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1288:
1278:
1276:
1268:
1267:
1263:
1253:
1251:
1238:
1237:
1233:
1226:
1211:
1210:
1206:
1199:
1182:
1181:
1174:
1144:
1143:
1136:
1100:
1099:
1095:
1085:
1083:
1078:
1077:
1064:
1034:
1033:
1029:
1019:
1017:
1005:
1004:
1000:
993:Merriam-Webster
987:
986:
982:
977:
961:muscle relaxant
957:
949:
937:pseudoephedrine
899:Guaifenesin is
897:
892:
834:
810:
805:
781:
773:clinical trials
769:Cochrane review
746:
680:
678:
673:
670:
665:
660:
659:
648:
645:
640:
639:
627:Racemic mixture
616:
591:
581:
575:
569:
530:
506:
498:
478:
458:
438:
418:
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378:
361:
353:
333:
330:
321:
320:
298:
277:Pharmacokinetic
271:
264:
238:
196:
189:
119:Mucinex, others
70:
66:
28:
23:
22:
15:
12:
11:
5:
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2277:
2272:
2267:
2262:
2257:
2252:
2247:
2242:
2237:
2223:
2218:
2213:
2208:
2206:Dihydrocodeine
2203:
2198:
2188:
2183:
2181:Benzylmorphine
2178:
2172:
2170:
2153:
2147:
2146:
2144:
2143:
2138:
2133:
2128:
2123:
2118:
2113:
2108:
2103:
2098:
2093:
2088:
2083:
2078:
2073:
2071:Acetylcysteine
2067:
2065:
2059:
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2020:
2002:
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1721:
1716:
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1706:
1700:
1698:
1694:
1693:
1691:
1690:
1688:Isobromindione
1685:
1680:
1678:Sulfinpyrazone
1675:
1669:
1667:
1660:
1654:
1653:
1642:
1640:
1639:
1632:
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1617:
1611:
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1594:
1593:External links
1591:
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1113:(5): 631–636.
1093:
1062:
1043:(9): 803–808.
1027:
998:
979:
978:
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956:
955:Veterinary use
953:
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1387:"Guaifenesin"
1382:
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911:or part of a
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880:timed-release
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855:Pharmacognosy
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846:Santo Domingo
843:
842:North America
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537:ECHA InfoCard
533:
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520:DTXSID5023114
517:
516:
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65:
63:Pronunciation
61:
58:Clinical data
56:
52:
47:
43:
38:
30:
19:
2545:Expectorants
2366:Droxypropine
2361:Dropropizine
2341:Cloperastine
2311:Benproperine
2275:Normethadone
2234:+homatropine
2230:+guaifenesin
2195:+guaifenesin
2101:Dornase alfa
2017:+oxomemazine
2013:+hydrocodone
2004:
1967:Expectorants
1851:
1806:Topiroxostat
1800:Myo-inositol
1718:
1709:Atorvastatin
1603:
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1470:the original
1460:
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1443:
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1362:. Retrieved
1352:
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1289:
1277:. Retrieved
1273:
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853:Textbook of
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785:side-effects
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691:
690:
679:
326:
297:Elimination
249:Legal status
243:Legal status
165:License data
29:
2481:from market
2441:Piperidione
2406:Moguisteine
2316:Benzonatate
2306:Alloclamide
2265:Nicocodeine
2226:Hydrocodone
2186:Butorphanol
2131:Neltenexine
2028:Ipecacuanha
2005:Guaifenesin
1975:Althea root
1896:from market
1874:Pegloticase
1869:Rasburicase
1795:Phytic acid
1760:Allopurinol
1719:Guaifenesin
1714:Fenofibrate
1658:Uricosurics
1522:Mayo Clinic
1502:16 November
1476:16 November
1147:Respir Care
925:paracetamol
905:brand names
895:Brand names
838:guaiac tree
750:antitussive
744:Medical use
700:expectorant
692:Guaifenesin
594: g·mol
543:100.002.021
309:Identifiers
184:Guaifenesin
151:MedlinePlus
124:Other names
115:Trade names
34:Guaifenesin
2534:Categories
2451:Tipepidine
2436:Pipazetate
2416:Nepinalone
2411:Morclofone
2401:Meprotixol
2391:Isoaminile
2381:Gefapixant
2336:Clofedanol
2331:Clobutinol
2326:Butamirate
2285:Pholcodine
2211:Dimemorfan
2162:alkaloids,
2116:Letosteine
2111:Erdosteine
2106:Eprazinone
2081:Bromhexine
2063:Mucolytics
1844:Cinchophen
1828:Colchicine
1786:Febuxostat
1770:Tisopurine
1765:Oxypurinol
1704:Amlodipine
1673:Probenecid
1450:26 October
1279:14 January
1254:14 January
1020:22 October
975:References
921:analgesics
703:medication
599:3D model (
587:Molar mass
453:495W7451VQ
424:ChemSpider
384:IUPHAR/BPS
339:CAS Number
318:IUPAC name
285:Metabolism
2491:Phase III
2479:Withdrawn
2426:Oxolamine
2376:Fominoben
2371:Fedrilate
2280:Noscapine
2260:Methadone
2141:Stepronin
2053:Tyloxapol
1906:Phase III
1894:Withdrawn
1860:Sevelamer
1791:Inositols
1724:Lesinurad
1697:secondary
947:Economics
933:ephedrine
758:ephedrine
723:glycerine
709:from the
622:Chirality
493:ChEMBL980
304:1–5 hours
299:half-life
195:Routes of
143:Monograph
137:Drugs.com
2524:Medicine
2456:Zipeprol
2421:Oxeladin
2386:Glaucine
2346:Dibunate
2290:Thebacon
2245:Laudanum
2136:Sobrerol
2121:Mannitol
2096:Domiodol
2076:Ambroxol
2009:+codeine
1995:Creosote
1729:Losartan
1582:23498047
1344:25420096
1274:ClinCalc
1248:Archived
1244:ClinCalc
1167:24789023
1129:24003241
969:xylazine
965:ketamine
931:such as
923:such as
797:vomiting
791:(rare),
719:guaiacol
698:, is an
682:(verify)
404:DrugBank
227:QM03BX90
209:ATC code
202:By mouth
179:DailyMed
2191:Codeine
2165:opioids
1990:Cineole
1855:aspirin
1666:primary
1527:27 July
1393:30 July
1364:30 July
1335:7061814
1086:30 July
1057:8218524
832:History
822:pharynx
818:bronchi
814:trachea
592:198.218
560:Formula
413:DB00874
359:PubChem
348:93-14-1
265:WARNING
229: (
225:)
219: (
217:R05CA03
181::
157:a682494
18:Mucinex
2510:Portal
2474:WHO-EM
2221:Heroin
2048:Senega
1889:WHO-EM
1852:except
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793:nausea
762:asthma
707:sputum
637:SMILES
484:ChEMBL
473:D00337
290:Kidney
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2299:Other
2160:Opium
2126:Mesna
1837:Other
1779:other
939:, or
715:ether
657:InChI
601:JSmol
1645:gout
1578:PMID
1529:2021
1504:2010
1478:2010
1452:2022
1395:2023
1366:2023
1340:PMID
1318:2014
1281:2024
1256:2024
1220:ISBN
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816:and
736:and
721:and
464:KEGG
444:UNII
433:3396
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1958:R05
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1570:doi
1330:PMC
1322:doi
1155:doi
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1045:doi
1015:FDA
717:of
509:EPA
363:CID
232:WHO
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