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in older dogs from medium or large breeds. Its biological behaviour may range from benign to malignant, as it has the potential to invade, metastasise and recur. Histologically, it is characterised by the dominant presence of multiple osteoid- or cartilage- containing lobules that are separated by
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O'Brien MG, Withrow SJ, Straw RC, Powers BE, Kirpensteijn JK. Total and partial orbitectomy for the treatment of periorbital tumors in 24 dogs and 6 cats: a retrospective study. Vet Surg 1996, 25, 471-479
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Psychas V, Loukopoulos P, Polizopoulou ZS, Sofianidis G. Multilobular tumour of the caudal cranium causing severe cerebral and cerebellar compression in a dog. J Vet Sci 2009; 10:81-83
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fibrous septae. MTB should be differentiated from other bone tumours. Although most frequently found in dogs, MTB has been reported in humans, cats, a horse and a ferret. The
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Straw RC, LeCouteur RA, Powers BE, Withrow SJ. Multilobular osteochondrosarcoma of the canine skull: 16 cases (1978-1988). J Am Vet Med Assoc 1989, 195, 1764-1769
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Dernell WS, Straw RC, Cooper MF, Powers BE, LaRue SM, Withrow SJ. Multilobular osteochondrosarcoma in 39 dogs: 1979-1993. J Am Anim Hosp Assoc 1998, 34, 11-18
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Loukopoulos P, Thornton JR, Robinson WF. Clinical and pathologic relevance of p53 index in canine osseous tumors. Veterinary
Pathology 2003; 40:237-248.
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23:(MTB), also called an osteochondrosarcoma, is the most common tumour of the canine skull, although it is relatively rare in general.
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Slayter MV, Boosinger TR, Pool RR, Dammrich K, Misdorp W, Larsen S. Histological
Classification of Bone and Joint Tumors of
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Hanley CS, Gieger T, Frank P. What is your diagnosis? Multilobular osteoma (MLO). J Am Vet Med Assoc 2004, 225, 1665-1666
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Thompson KG, Pool RR. Tumors of bones. In: Meuten DJ (ed.). Tumors in
Domestic Animals. 4th ed. pp. 296-298,
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Jacobson SA. The
Comparative Pathology of the Tumors of Bone. pp. 102-109, Thomas, Springfield, 1971
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depend on the tumour location. Depending on its location and stage in the clinical course,
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MTB usually presents as a firm, circumscribed and generally slowgrowing
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Rossetti E, Bertolini G, Zotti A. Multilobular tumour of bone of the
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157:in a cat. J Feline Med Surg 2007, 9, 254-257
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191:Osseous and chondromatous neoplasia
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16:Tumour of the Canine skull
115:Iowa State University
104:, Washington DC, 1994
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