244:
221:
118:
143:
250:
149:
2955:
1211:
MAG is a critical protein in the formation and maintenance of myelin sheaths. MAG is localized on the inner membrane of the myelin sheath and interacts with axonal membrane proteins to attach the myelin sheath to the axon. Mutations to the MAG gene are implicated in demyelination diseases such as
1185:
MAG is a 100 kDA glycoprotein. Uncleaved MAG is a complete transmembrane form, which acts as a signaling and adhesion molecule. MAG can also act as a signaling molecule as a soluble protein after it has been proteolytically shed. This form of the protein is called dMAG.
1198:(Ig) domains and a homodimeric arrangement involving membrane-proximal domains Ig4 and Ig5. MAG-oligosaccharide complex structures and biophysical assays show how MAG engages axonal gangliosides at domain Ig1.
1897:
McKerracher L, David S, Jackson DL, Kottis V, Dunn RJ, Braun PE (October 1994). "Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth".
1527:
McKerracher L, David S, Jackson DL, Kottis V, Dunn RJ, Braun PE (October 1994). "Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth".
1244:
the has redundant ligands, furthering the inhibition. MAG binds with high affinity to NgR, suggesting that it is equally as responsible for inhibition of axon regeneration as Nogo.
2444:
1177:
MAG is one of three main myelin-associated inhibitors of axonal regeneration after injury, making it an important protein for future research on neurogenesis in the CNS.
1940:
Mukhopadhyay G, Doherty P, Walsh FS, Crocker PR, Filbin MT (September 1994). "A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration".
257:
156:
2878:
2938:
1232:
is regulated by three main proteins, one of which is MAG. The exact mechanism through which MAG inhibits neuroregeneration appears to be through binding of
2437:
804:
785:
79:
2674:
2669:
3034:
2422:
3000:
1145:
localized in periaxonal
Schwann cell and oligodendrocyte membranes, where it plays a role in glial-axonal interactions. MAG is a member of the
3019:
2430:
1775:
1587:
1382:
1364:
2641:
1280:
1654:"Myelin-associated glycoprotein interacts with neurons via a sialic acid binding site at ARG118 and a distinct neurite inhibition site"
243:
1076:
2156:
1083:
1256:(ROCK) pathway. The activation of the rho kinase pathway leads to the phosphorylation of proteins which inhibit neurite outgrowth.
220:
1445:"The myelin-associated glycoprotein gene: mapping to human chromosome 19 and mouse chromosome 7 and expression in quivering mice"
1983:
Domeniconi M, Cao Z, Spencer T, Sivasankaran R, Wang K, Nikulina E, Kimura N, Cai H, Deng K, Gao Y, He Z, Filbin M (July 2002).
1351:
1330:
1285:
142:
117:
1347:
1253:
1326:
2342:
1139:
59:
2192:
2993:
2629:
256:
155:
2220:
1225:
1166:
249:
148:
1301:
849:
67:
1613:"Myelin-associated glycoprotein interacts with ganglioside GT1b. A mechanism for neurite outgrowth inhibition"
2910:
830:
1297:
1221:
1174:
2986:
2634:
2461:
2207:
2149:
1195:
131:
1799:
Pronker MF, Lemstra S, Snijder J, Heck AJ, Thies-Weesie DM, Pasterkamp RJ, Janssen BJ (December 2016).
1701:
Pronker MF, Lemstra S, Snijder J, Heck AJ, Thies-Weesie DM, Pasterkamp RJ, Janssen BJ (December 2016).
2661:
2617:
2511:
2045:
1812:
1714:
1275:
1241:
1233:
1154:
1240:
protein, suggesting that the mechanism of myelin-associated inhibition of axon regeneration through
46:
2651:
2394:
1059:
1051:
1041:
1037:
1033:
1029:
1025:
1002:
976:
972:
968:
958:
954:
950:
946:
923:
1652:
Tang S, Shen YJ, DeBellard ME, Mukhopadhyay G, Salzer JL, Crocker PR, Filbin MT (September 1997).
2120:
2071:
2014:
1965:
1922:
1552:
1509:
1425:
91:
1985:"Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowth"
1055:
1010:
1006:
942:
927:
919:
2112:
2063:
2006:
1957:
1914:
1879:
1838:
1781:
1771:
1740:
1683:
1634:
1593:
1583:
1544:
1501:
1466:
1417:
1229:
39:
2970:
2857:
2852:
2797:
2787:
2782:
2772:
2767:
2762:
2742:
1758:
Lopez PH (2014). "Role of Myelin-Associated
Glycoprotein (Siglec-4a) in the Nervous System".
1570:
Lopez PH (2014). "Role of Myelin-Associated
Glycoprotein (Siglec-4a) in the Nervous System".
1150:
3024:
2883:
2712:
2692:
2599:
2594:
2589:
2584:
2579:
2574:
2564:
2554:
2549:
2539:
2534:
2457:
2399:
2214:
2142:
2102:
2053:
1996:
1949:
1906:
1869:
1828:
1820:
1763:
1730:
1722:
1673:
1665:
1624:
1575:
1536:
1493:
1456:
1409:
336:
267:
211:
166:
2569:
2544:
1400:
Quarles RH (March 2007). "Myelin-associated glycoprotein (MAG): past, present and beyond".
3029:
2496:
2491:
311:
87:
2049:
1816:
1718:
2389:
1833:
1800:
1735:
1702:
1678:
1653:
1270:
1170:
2001:
1984:
1611:
Vinson M, Strijbos PJ, Rowles A, Facci L, Moore SE, Simmons DL, Walsh FS (June 2001).
719:
714:
709:
704:
699:
694:
689:
684:
679:
674:
669:
664:
659:
654:
649:
644:
628:
623:
618:
613:
608:
603:
598:
593:
588:
583:
578:
573:
557:
552:
547:
542:
537:
532:
527:
3013:
2966:
2406:
2184:
1953:
1910:
1540:
1461:
1444:
1413:
514:
2124:
2018:
1926:
1556:
1513:
2469:
2332:
2261:
2075:
1429:
1142:
329:
108:
1969:
71:
1874:
1857:
1767:
1579:
95:
2822:
2684:
2034:"Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor"
1387:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1369:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1237:
1158:
412:
2905:
2888:
2486:
2367:
1497:
228:
125:
75:
2915:
2202:
2058:
2033:
1801:"Structural basis of myelin-associated glycoprotein adhesion and signalling"
1703:"Structural basis of myelin-associated glycoprotein adhesion and signalling"
1484:
Bjartmar C, Yin X, Trapp BD (1999). "Axonal pathology in myelin disorders".
749:
472:
350:
295:
282:
194:
181:
83:
2116:
2067:
2010:
1883:
1842:
1785:
1744:
1669:
1638:
1629:
1612:
1597:
1505:
1421:
1961:
1918:
1687:
1548:
1470:
1169:
and is vital for the long-term survival of the myelinated axons following
1123:
1118:
2873:
2478:
2347:
2337:
2327:
2311:
2306:
2241:
2236:
2231:
2226:
1107:
894:
875:
1824:
1726:
2847:
2842:
2802:
2792:
2777:
2757:
2752:
2747:
2737:
2453:
2384:
2301:
2296:
2291:
2286:
2281:
2165:
2107:
2090:
861:
816:
2732:
2727:
2722:
2717:
2707:
2702:
2697:
2609:
2465:
2411:
2253:
2169:
1265:
1146:
1091:
771:
2954:
2091:"Axon growth inhibition: signals from the p75 neurotrophin receptor"
2134:
50:, GMA, S-SIGLEC-4A, SIGLEC4A, SPG75, myelin associated glycoprotein
2898:
2893:
2807:
2559:
2529:
2524:
2377:
2372:
2197:
1162:
1443:
Barton DE, Arquint M, Roder J, Dunn R, Francke U (October 1987).
734:
730:
2962:
2925:
2920:
2837:
2827:
2817:
2812:
2622:
2519:
2501:
2271:
2266:
63:
2426:
2138:
2032:
Liu BP, Fournier A, GrandPré T, Strittmatter SM (August 2002).
2832:
1224:
do not regenerate after injury the same way that axons in the
1858:"Neural stem cells: generating and regenerating the brain"
1762:. Advances in Neurobiology. Vol. 9. pp. 245–62.
1574:. Advances in Neurobiology. Vol. 9. pp. 245–62.
710:
cell-cell adhesion via plasma-membrane adhesion molecules
319:
2974:
1252:
Once MAG (or Nogo) has bound to NgR, NgR activates the
1149:
family of proteins and is a functional ligand of the
484:
655:
negative regulation of neuron projection development
2866:
2683:
2660:
2608:
2510:
2477:
2360:
2320:
2252:
2183:
2176:
1024:
995:
941:
912:
1343:
1341:
1339:
1322:
1320:
1318:
266:
165:
690:positive regulation of astrocyte differentiation
2879:LDL-receptor-related protein-associated protein
680:negative regulation of neuron apoptotic process
18:Protein-coding gene in the species Homo sapiens
1348:GRCm38: Ensembl release 89: ENSMUSG00000036634
2994:
2438:
2150:
685:negative regulation of neuron differentiation
8:
1228:do. The mechanism responsible for inhibited
1327:GRCh38: Ensembl release 89: ENSG00000105695
3001:
2987:
2445:
2431:
2423:
2180:
2157:
2143:
2135:
1021:
938:
745:
510:
307:
206:
103:
2675:Pulmonary surfactant-associated protein C
2670:Pulmonary surfactant-associated protein B
2106:
2057:
2000:
1873:
1832:
1734:
1677:
1628:
1460:
1300:at the U.S. National Library of Medicine
1194:MAG has an extended conformation of five
705:cellular response to mechanical stimulus
1314:
20:
2939:other cell membrane protein disorders
670:negative regulation of axon extension
584:integral component of plasma membrane
271:
232:
227:
170:
129:
124:
7:
2951:
2949:
1157:. MAG is believed to be involved in
2642:Myelin oligodendrocyte glycoprotein
1617:The Journal of Biological Chemistry
1281:Myelin oligodendrocyte glycoprotein
695:negative regulation of axonogenesis
2973:. You can help Knowledge (XXG) by
1856:Gage FH, Temple S (October 2013).
1760:Glycobiology of the Nervous System
1572:Glycobiology of the Nervous System
992:
909:
885:
866:
840:
821:
795:
776:
675:positive regulation of myelination
665:central nervous system myelination
489:
451:central gray substance of midbrain
407:
345:
324:
14:
2089:Kaplan DR, Miller FD (May 2003).
1236:. This receptor is also bound by
553:protein homodimerization activity
2953:
1414:10.1111/j.1471-4159.2006.04319.x
1216:Inhibition of nerve regeneration
439:lumbar subsegment of spinal cord
365:inferior ganglion of vagus nerve
255:
248:
242:
219:
154:
147:
141:
116:
3035:Human chromosome 19 gene stubs
2911:Phospholipid transfer proteins
2647:Myelin-associated glycoprotein
2277:Myelin-associated glycoprotein
1298:Myelin-associated+glycoprotein
1286:Anti-MAG peripheral neuropathy
1136:Myelin-associated glycoprotein
594:integral component of membrane
473:More reference expression data
1:
2002:10.1016/s0896-6273(02)00770-5
715:transmission of nerve impulse
604:myelin sheath adaxonal region
240:
139:
3020:Genes on human chromosome 19
2343:N-Acetylglucosamine receptor
1954:10.1016/0896-6273(94)90042-6
1911:10.1016/0896-6273(94)90247-x
1875:10.1016/j.neuron.2013.10.037
1768:10.1007/978-1-4939-1154-7_11
1580:10.1007/978-1-4939-1154-7_11
1541:10.1016/0896-6273(94)90247-x
1462:10.1016/0888-7543(87)90002-4
1140:type 1 transmembrane protein
660:substantia nigra development
2193:Asialoglycoprotein receptor
1658:The Journal of Cell Biology
381:superior vestibular nucleus
3051:
2948:
2630:Myelin proteolipid protein
650:nervous system development
619:Schmidt-Lanterman incisure
528:signaling receptor binding
431:lateral geniculate nucleus
2934:
2221:proteochondroitin sulfate
1402:Journal of Neurochemistry
1383:"Mouse PubMed Reference:"
1365:"Human PubMed Reference:"
1226:peripheral nervous system
1122:
1117:
1113:
1106:
1090:
1071:
1048:
999:
988:
965:
916:
905:
892:
888:
873:
869:
860:
847:
843:
828:
824:
815:
802:
798:
783:
779:
770:
755:
748:
744:
728:
513:
509:
497:
492:
483:
470:
459:medial geniculate nucleus
419:
410:
357:
348:
318:
310:
306:
289:
276:
239:
218:
209:
205:
188:
175:
138:
115:
106:
102:
57:
54:
44:
37:
32:
28:
23:
1486:Journal of Neurocytology
1302:Medical Subject Headings
1207:Myelin-axon interactions
1077:Chr 19: 35.29 – 35.31 Mb
558:ganglioside GT1b binding
443:dorsal tegmental nucleus
389:external globus pallidus
2059:10.1126/science.1073031
1498:10.1023/a:1007010205037
599:paranode region of axon
1670:10.1083/jcb.138.6.1355
1630:10.1074/jbc.M100345200
1222:central nervous system
1084:Chr 7: 30.6 – 30.61 Mb
538:protein kinase binding
447:ventral tegmental area
423:deep cerebellar nuclei
393:ventral tegmental area
2462:Cell surface receptor
2208:Mannan-binding lectin
1805:Nature Communications
1707:Nature Communications
1138:(MAG, Siglec-4) is a
132:Chromosome 19 (human)
2662:Pulmonary surfactant
2618:Myelin basic protein
2512:Membrane-spanning 4A
1212:multiple sclerosis.
1165:regeneration in the
543:carbohydrate binding
369:middle frontal gyrus
273:7 B1|7 19.26 cM
234:Chromosome 7 (mouse)
2652:Myelin protein zero
2395:Phytohaemagglutinin
2095:Nature Neuroscience
2050:2002Sci...297.1190L
1825:10.1038/ncomms13584
1817:2016NatCo...713584P
1727:10.1038/ncomms13584
1719:2016NatCo...713584P
700:leukocyte migration
548:sialic acid binding
385:subthalamic nucleus
2961:This article on a
2108:10.1038/nn0503-435
1248:Rho kinase pathway
850:ENSMUSG00000036634
638:Biological process
567:Cellular component
521:Molecular function
2982:
2981:
2946:
2945:
2458:membrane proteins
2420:
2419:
2356:
2355:
1777:978-1-4939-1153-0
1589:978-1-4939-1153-0
1230:neuroregeneration
1133:
1132:
1129:
1128:
1102:
1101:
1067:
1066:
1018:
1017:
984:
983:
935:
934:
901:
900:
882:
881:
856:
855:
837:
836:
811:
810:
792:
791:
740:
739:
720:axon regeneration
505:
504:
501:
500:
479:
478:
466:
465:
455:medulla oblongata
404:
403:
302:
301:
201:
200:
3042:
3003:
2996:
2989:
2957:
2950:
2447:
2440:
2433:
2424:
2400:Pokeweed mitogen
2215:Mannose receptor
2181:
2159:
2152:
2145:
2136:
2129:
2128:
2110:
2086:
2080:
2079:
2061:
2044:(5584): 1190–3.
2029:
2023:
2022:
2004:
1980:
1974:
1973:
1937:
1931:
1930:
1894:
1888:
1887:
1877:
1853:
1847:
1846:
1836:
1796:
1790:
1789:
1755:
1749:
1748:
1738:
1698:
1692:
1691:
1681:
1649:
1643:
1642:
1632:
1608:
1602:
1601:
1567:
1561:
1560:
1524:
1518:
1517:
1481:
1475:
1474:
1464:
1440:
1434:
1433:
1397:
1391:
1390:
1379:
1373:
1372:
1361:
1355:
1345:
1334:
1324:
1115:
1114:
1086:
1079:
1062:
1022:
1013:
993:
989:RefSeq (protein)
979:
939:
930:
910:
886:
867:
841:
822:
796:
777:
746:
511:
490:
475:
415:
413:Top expressed in
408:
353:
351:Top expressed in
346:
325:
308:
298:
285:
274:
259:
252:
246:
235:
223:
207:
197:
184:
173:
158:
151:
145:
134:
120:
104:
98:
49:
42:
21:
3050:
3049:
3045:
3044:
3043:
3041:
3040:
3039:
3010:
3009:
3008:
3007:
2947:
2942:
2930:
2884:Neurofibromin 2
2867:Other/ungrouped
2862:
2679:
2656:
2604:
2506:
2473:
2451:
2421:
2416:
2352:
2316:
2248:
2172:
2163:
2133:
2132:
2088:
2087:
2083:
2031:
2030:
2026:
1982:
1981:
1977:
1939:
1938:
1934:
1896:
1895:
1891:
1855:
1854:
1850:
1798:
1797:
1793:
1778:
1757:
1756:
1752:
1700:
1699:
1695:
1651:
1650:
1646:
1623:(23): 20280–5.
1610:
1609:
1605:
1590:
1569:
1568:
1564:
1526:
1525:
1521:
1492:(4–5): 383–95.
1483:
1482:
1478:
1442:
1441:
1437:
1399:
1398:
1394:
1381:
1380:
1376:
1363:
1362:
1358:
1346:
1337:
1325:
1316:
1311:
1294:
1262:
1250:
1218:
1209:
1204:
1192:
1183:
1124:View/Edit Mouse
1119:View/Edit Human
1082:
1075:
1072:Location (UCSC)
1058:
1054:
1050:
1044:
1040:
1036:
1032:
1028:
1009:
1005:
1001:
975:
971:
967:
961:
957:
953:
949:
945:
926:
922:
918:
831:ENSG00000105695
724:
633:
579:plasma membrane
562:
471:
462:
457:
453:
449:
445:
441:
437:
435:globus pallidus
433:
429:
425:
411:
400:
397:pars reticulata
395:
391:
387:
383:
379:
375:
373:corpus callosum
371:
367:
363:
349:
293:
280:
272:
262:
261:
260:
253:
233:
210:Gene location (
192:
179:
171:
161:
160:
159:
152:
130:
107:Gene location (
96:MAG - orthologs
58:
45:
38:
19:
12:
11:
5:
3048:
3046:
3038:
3037:
3032:
3027:
3022:
3012:
3011:
3006:
3005:
2998:
2991:
2983:
2980:
2979:
2958:
2944:
2943:
2935:
2932:
2931:
2929:
2928:
2923:
2918:
2913:
2908:
2903:
2902:
2901:
2896:
2886:
2881:
2876:
2870:
2868:
2864:
2863:
2861:
2860:
2855:
2850:
2845:
2840:
2835:
2830:
2825:
2820:
2815:
2810:
2805:
2800:
2795:
2790:
2785:
2780:
2775:
2770:
2765:
2760:
2755:
2750:
2745:
2740:
2735:
2730:
2725:
2720:
2715:
2710:
2705:
2700:
2695:
2689:
2687:
2681:
2680:
2678:
2677:
2672:
2666:
2664:
2658:
2657:
2655:
2654:
2649:
2644:
2639:
2638:
2637:
2627:
2626:
2625:
2614:
2612:
2606:
2605:
2603:
2602:
2597:
2592:
2587:
2582:
2577:
2572:
2567:
2562:
2557:
2552:
2547:
2542:
2537:
2532:
2527:
2522:
2516:
2514:
2508:
2507:
2505:
2504:
2499:
2494:
2489:
2483:
2481:
2475:
2474:
2452:
2450:
2449:
2442:
2435:
2427:
2418:
2417:
2415:
2414:
2409:
2404:
2403:
2402:
2397:
2392:
2390:Concanavalin A
2382:
2381:
2380:
2375:
2364:
2362:
2358:
2357:
2354:
2353:
2351:
2350:
2345:
2340:
2335:
2330:
2324:
2322:
2318:
2317:
2315:
2314:
2309:
2304:
2299:
2294:
2289:
2284:
2279:
2274:
2269:
2264:
2258:
2256:
2250:
2249:
2247:
2246:
2245:
2244:
2239:
2234:
2229:
2217:
2212:
2211:
2210:
2200:
2195:
2189:
2187:
2185:C-type lectins
2178:
2174:
2173:
2164:
2162:
2161:
2154:
2147:
2139:
2131:
2130:
2081:
2024:
1975:
1932:
1889:
1868:(3): 588–601.
1848:
1791:
1776:
1750:
1693:
1664:(6): 1355–66.
1644:
1603:
1588:
1562:
1519:
1476:
1435:
1408:(6): 1431–48.
1392:
1374:
1356:
1335:
1313:
1312:
1310:
1307:
1306:
1305:
1293:
1292:External links
1290:
1289:
1288:
1283:
1278:
1273:
1271:Myelinogenesis
1268:
1261:
1258:
1249:
1246:
1217:
1214:
1208:
1205:
1203:
1200:
1196:immunoglobulin
1191:
1188:
1182:
1179:
1171:myelinogenesis
1131:
1130:
1127:
1126:
1121:
1111:
1110:
1104:
1103:
1100:
1099:
1097:
1095:
1088:
1087:
1080:
1073:
1069:
1068:
1065:
1064:
1046:
1045:
1019:
1016:
1015:
997:
996:
990:
986:
985:
982:
981:
963:
962:
936:
933:
932:
914:
913:
907:
903:
902:
899:
898:
890:
889:
883:
880:
879:
871:
870:
864:
858:
857:
854:
853:
845:
844:
838:
835:
834:
826:
825:
819:
813:
812:
809:
808:
800:
799:
793:
790:
789:
781:
780:
774:
768:
767:
762:
757:
753:
752:
742:
741:
738:
737:
726:
725:
723:
722:
717:
712:
707:
702:
697:
692:
687:
682:
677:
672:
667:
662:
657:
652:
647:
641:
639:
635:
634:
632:
631:
626:
621:
616:
614:compact myelin
611:
606:
601:
596:
591:
586:
581:
576:
570:
568:
564:
563:
561:
560:
555:
550:
545:
540:
535:
530:
524:
522:
518:
517:
507:
506:
503:
502:
499:
498:
495:
494:
487:
481:
480:
477:
476:
468:
467:
464:
463:
461:
460:
456:
452:
448:
444:
440:
436:
432:
428:
427:pontine nuclei
424:
420:
417:
416:
405:
402:
401:
399:
398:
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
355:
354:
342:
341:
333:
322:
316:
315:
312:RNA expression
304:
303:
300:
299:
291:
287:
286:
278:
275:
270:
264:
263:
254:
247:
241:
237:
236:
231:
225:
224:
216:
215:
203:
202:
199:
198:
190:
186:
185:
177:
174:
169:
163:
162:
153:
146:
140:
136:
135:
128:
122:
121:
113:
112:
100:
99:
56:
52:
51:
43:
35:
34:
30:
29:
26:
25:
17:
13:
10:
9:
6:
4:
3:
2:
3047:
3036:
3033:
3031:
3028:
3026:
3023:
3021:
3018:
3017:
3015:
3004:
2999:
2997:
2992:
2990:
2985:
2984:
2978:
2976:
2972:
2968:
2967:chromosome 19
2964:
2959:
2956:
2952:
2941:
2940:
2933:
2927:
2924:
2922:
2919:
2917:
2914:
2912:
2909:
2907:
2904:
2900:
2897:
2895:
2892:
2891:
2890:
2887:
2885:
2882:
2880:
2877:
2875:
2872:
2871:
2869:
2865:
2859:
2856:
2854:
2851:
2849:
2846:
2844:
2841:
2839:
2836:
2834:
2831:
2829:
2826:
2824:
2821:
2819:
2816:
2814:
2811:
2809:
2806:
2804:
2801:
2799:
2796:
2794:
2791:
2789:
2786:
2784:
2781:
2779:
2776:
2774:
2771:
2769:
2766:
2764:
2761:
2759:
2756:
2754:
2751:
2749:
2746:
2744:
2741:
2739:
2736:
2734:
2731:
2729:
2726:
2724:
2721:
2719:
2716:
2714:
2711:
2709:
2706:
2704:
2701:
2699:
2696:
2694:
2691:
2690:
2688:
2686:
2682:
2676:
2673:
2671:
2668:
2667:
2665:
2663:
2659:
2653:
2650:
2648:
2645:
2643:
2640:
2636:
2633:
2632:
2631:
2628:
2624:
2621:
2620:
2619:
2616:
2615:
2613:
2611:
2607:
2601:
2598:
2596:
2593:
2591:
2588:
2586:
2583:
2581:
2578:
2576:
2573:
2571:
2568:
2566:
2563:
2561:
2558:
2556:
2553:
2551:
2548:
2546:
2543:
2541:
2538:
2536:
2533:
2531:
2528:
2526:
2523:
2521:
2518:
2517:
2515:
2513:
2509:
2503:
2500:
2498:
2495:
2493:
2490:
2488:
2485:
2484:
2482:
2480:
2476:
2471:
2467:
2463:
2459:
2455:
2448:
2443:
2441:
2436:
2434:
2429:
2428:
2425:
2413:
2410:
2408:
2407:Legume lectin
2405:
2401:
2398:
2396:
2393:
2391:
2388:
2387:
2386:
2383:
2379:
2376:
2374:
2371:
2370:
2369:
2366:
2365:
2363:
2359:
2349:
2346:
2344:
2341:
2339:
2336:
2334:
2331:
2329:
2326:
2325:
2323:
2319:
2313:
2310:
2308:
2305:
2303:
2300:
2298:
2295:
2293:
2290:
2288:
2285:
2283:
2280:
2278:
2275:
2273:
2270:
2268:
2265:
2263:
2260:
2259:
2257:
2255:
2251:
2243:
2240:
2238:
2235:
2233:
2230:
2228:
2225:
2224:
2223:
2222:
2218:
2216:
2213:
2209:
2206:
2205:
2204:
2201:
2199:
2196:
2194:
2191:
2190:
2188:
2186:
2182:
2179:
2175:
2171:
2167:
2160:
2155:
2153:
2148:
2146:
2141:
2140:
2137:
2126:
2122:
2118:
2114:
2109:
2104:
2100:
2096:
2092:
2085:
2082:
2077:
2073:
2069:
2065:
2060:
2055:
2051:
2047:
2043:
2039:
2035:
2028:
2025:
2020:
2016:
2012:
2008:
2003:
1998:
1995:(2): 283–90.
1994:
1990:
1986:
1979:
1976:
1971:
1967:
1963:
1959:
1955:
1951:
1948:(3): 757–67.
1947:
1943:
1936:
1933:
1928:
1924:
1920:
1916:
1912:
1908:
1905:(4): 805–11.
1904:
1900:
1893:
1890:
1885:
1881:
1876:
1871:
1867:
1863:
1859:
1852:
1849:
1844:
1840:
1835:
1830:
1826:
1822:
1818:
1814:
1810:
1806:
1802:
1795:
1792:
1787:
1783:
1779:
1773:
1769:
1765:
1761:
1754:
1751:
1746:
1742:
1737:
1732:
1728:
1724:
1720:
1716:
1712:
1708:
1704:
1697:
1694:
1689:
1685:
1680:
1675:
1671:
1667:
1663:
1659:
1655:
1648:
1645:
1640:
1636:
1631:
1626:
1622:
1618:
1614:
1607:
1604:
1599:
1595:
1591:
1585:
1581:
1577:
1573:
1566:
1563:
1558:
1554:
1550:
1546:
1542:
1538:
1535:(4): 805–11.
1534:
1530:
1523:
1520:
1515:
1511:
1507:
1503:
1499:
1495:
1491:
1487:
1480:
1477:
1472:
1468:
1463:
1458:
1455:(2): 107–12.
1454:
1450:
1446:
1439:
1436:
1431:
1427:
1423:
1419:
1415:
1411:
1407:
1403:
1396:
1393:
1388:
1384:
1378:
1375:
1370:
1366:
1360:
1357:
1353:
1349:
1344:
1342:
1340:
1336:
1332:
1328:
1323:
1321:
1319:
1315:
1308:
1303:
1299:
1296:
1295:
1291:
1287:
1284:
1282:
1279:
1277:
1274:
1272:
1269:
1267:
1264:
1263:
1259:
1257:
1255:
1247:
1245:
1243:
1239:
1235:
1231:
1227:
1223:
1220:Axons in the
1215:
1213:
1206:
1201:
1199:
1197:
1189:
1187:
1180:
1178:
1176:
1172:
1168:
1164:
1160:
1156:
1152:
1148:
1144:
1141:
1137:
1125:
1120:
1116:
1112:
1109:
1105:
1098:
1096:
1093:
1089:
1085:
1081:
1078:
1074:
1070:
1063:
1061:
1057:
1053:
1047:
1043:
1039:
1035:
1031:
1027:
1023:
1020:
1014:
1012:
1008:
1004:
998:
994:
991:
987:
980:
978:
974:
970:
964:
960:
956:
952:
948:
944:
940:
937:
931:
929:
925:
921:
915:
911:
908:
906:RefSeq (mRNA)
904:
897:
896:
891:
887:
884:
878:
877:
872:
868:
865:
863:
859:
852:
851:
846:
842:
839:
833:
832:
827:
823:
820:
818:
814:
807:
806:
801:
797:
794:
788:
787:
782:
778:
775:
773:
769:
766:
763:
761:
758:
754:
751:
747:
743:
736:
732:
727:
721:
718:
716:
713:
711:
708:
706:
703:
701:
698:
696:
693:
691:
688:
686:
683:
681:
678:
676:
673:
671:
668:
666:
663:
661:
658:
656:
653:
651:
648:
646:
645:cell adhesion
643:
642:
640:
637:
636:
630:
627:
625:
624:membrane raft
622:
620:
617:
615:
612:
610:
609:myelin sheath
607:
605:
602:
600:
597:
595:
592:
590:
587:
585:
582:
580:
577:
575:
572:
571:
569:
566:
565:
559:
556:
554:
551:
549:
546:
544:
541:
539:
536:
534:
533:lipid binding
531:
529:
526:
525:
523:
520:
519:
516:
515:Gene ontology
512:
508:
496:
491:
488:
486:
482:
474:
469:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
421:
418:
414:
409:
406:
396:
392:
388:
384:
380:
376:
372:
368:
364:
360:
359:
356:
352:
347:
344:
343:
340:
338:
334:
332:
331:
327:
326:
323:
321:
317:
313:
309:
305:
297:
292:
288:
284:
279:
269:
265:
258:
251:
245:
238:
230:
226:
222:
217:
213:
208:
204:
196:
191:
187:
183:
178:
168:
164:
157:
150:
144:
137:
133:
127:
123:
119:
114:
110:
105:
101:
97:
93:
89:
85:
81:
77:
73:
69:
65:
61:
53:
48:
41:
36:
31:
27:
22:
16:
2975:expanding it
2960:
2936:
2646:
2470:cytoskeleton
2460:(other than
2333:Calreticulin
2276:
2262:Sialoadhesin
2219:
2101:(5): 435–6.
2098:
2094:
2084:
2041:
2037:
2027:
1992:
1988:
1978:
1945:
1941:
1935:
1902:
1898:
1892:
1865:
1861:
1851:
1808:
1804:
1794:
1759:
1753:
1710:
1706:
1696:
1661:
1657:
1647:
1620:
1616:
1606:
1571:
1565:
1532:
1528:
1522:
1489:
1485:
1479:
1452:
1448:
1438:
1405:
1401:
1395:
1386:
1377:
1368:
1359:
1251:
1219:
1210:
1193:
1184:
1143:glycoprotein
1135:
1134:
1060:NP_001356191
1052:NP_001333018
1049:
1042:NP_001333017
1038:NP_001333016
1034:NP_001333015
1030:NP_001333014
1026:NP_001333013
1003:NP_001186145
1000:
977:NM_001369262
973:NM_001346089
969:NM_001346088
966:
959:NM_001346087
955:NM_001346086
951:NM_001346085
947:NM_001346084
924:NM_001199216
917:
893:
874:
848:
829:
803:
784:
764:
759:
335:
328:
55:External IDs
15:
2685:Tetraspanin
2368:Toxalbumins
1159:myelination
294:30,614,298
281:30,598,601
193:35,313,807
180:35,292,125
33:Identifiers
3014:Categories
2889:Presenilin
1354:, May 2017
1333:, May 2017
1309:References
1254:rho kinase
1153:receptor,
361:C1 segment
339:(ortholog)
76:HomoloGene
2965:on human
2937:see also
2916:Dysferlin
2203:Collectin
1811:: 13584.
1713:: 13584.
1181:Structure
1173:. In the
1056:NP_034888
1011:NP_542167
1007:NP_002352
943:NM_010758
928:NM_002361
920:NM_080600
750:Orthologs
574:cytoplasm
84:GeneCards
2874:Calnexin
2479:Arrestin
2385:Mitogens
2348:Selectin
2338:Galectin
2328:Calnexin
2312:SIGLEC12
2307:SIGLEC10
2242:Neurocan
2237:Brevican
2232:Versican
2227:Aggrecan
2125:40563260
2117:12715005
2068:12089450
2019:17970421
2011:12160746
1927:28429007
1884:24183012
1843:27922006
1786:25151382
1745:27922006
1639:11279053
1598:25151382
1557:28429007
1514:40528071
1506:10739578
1449:Genomics
1422:17241126
1350:–
1329:–
1260:See also
1202:Function
1190:Adhesion
1108:Wikidata
729:Sources:
589:membrane
172:19q13.12
3025:Lectins
2858:TSPAN34
2853:TSPAN33
2848:TSPAN32
2843:TSPAN31
2838:TSPAN30
2833:TSPAN29
2828:TSPAN28
2823:TSPAN27
2818:TSPAN26
2813:TSPAN25
2808:TSPAN24
2803:TSPAN23
2798:TSPAN22
2793:TSPAN21
2788:TSPAN20
2783:TSPAN19
2778:TSPAN18
2773:TSPAN17
2768:TSPAN16
2763:TSPAN15
2758:TSPAN14
2753:TSPAN13
2748:TSPAN12
2743:TSPAN11
2738:TSPAN10
2466:enzymes
2456:: cell
2454:Protein
2302:SIGLEC9
2297:SIGLEC8
2292:SIGLEC7
2287:SIGLEC6
2282:SIGLEC5
2170:lectins
2166:Protein
2076:1357777
2046:Bibcode
2038:Science
1962:7522484
1919:7524558
1834:5150538
1813:Bibcode
1736:5150538
1715:Bibcode
1688:9298990
1679:2132563
1549:7524558
1471:2447011
1430:1544418
1352:Ensembl
1331:Ensembl
1161:during
1151:NOGO-66
862:UniProt
817:Ensembl
756:Species
735:QuickGO
629:mesaxon
314:pattern
40:Aliases
3030:SIGLEC
2733:TSPAN9
2728:TSPAN8
2723:TSPAN7
2718:TSPAN6
2713:TSPAN5
2708:TSPAN4
2703:TSPAN3
2698:TSPAN2
2693:TSPAN1
2610:Myelin
2600:MS4A18
2595:MS4A15
2590:MS4A14
2585:MS4A13
2580:MS4A12
2575:MS4A10
2565:MS4A8B
2555:MS4A6E
2550:MS4A6A
2540:MS4A4E
2535:MS4A4A
2468:, and
2412:BanLec
2254:SIGLEC
2177:Animal
2123:
2115:
2074:
2066:
2017:
2009:
1989:Neuron
1970:928929
1968:
1960:
1942:Neuron
1925:
1917:
1899:Neuron
1882:
1862:Neuron
1841:
1831:
1784:
1774:
1743:
1733:
1686:
1676:
1637:
1596:
1586:
1555:
1547:
1529:Neuron
1512:
1504:
1469:
1428:
1420:
1304:(MeSH)
1266:Myelin
1147:SIGLEC
1094:search
1092:PubMed
895:P20917
876:P20916
772:Entrez
485:BioGPS
64:159460
2969:is a
2899:PSEN2
2894:PSEN1
2570:MS4A9
2560:MS4A7
2545:MS4A5
2530:MS4A3
2525:MS4A2
2520:MS4A1
2497:ARRB2
2492:ARRB1
2378:Ricin
2373:Abrin
2361:Plant
2321:Other
2198:KLRD1
2121:S2CID
2072:S2CID
2015:S2CID
1966:S2CID
1923:S2CID
1553:S2CID
1510:S2CID
1426:S2CID
1163:nerve
805:17136
765:Mouse
760:Human
731:Amigo
337:Mouse
330:Human
277:Start
212:Mouse
176:Start
109:Human
72:96912
2971:stub
2963:gene
2926:OTOF
2921:STRC
2635:PLP1
2623:PMP2
2502:ARR3
2272:CD33
2267:CD22
2113:PMID
2064:PMID
2007:PMID
1958:PMID
1915:PMID
1880:PMID
1839:PMID
1782:PMID
1772:ISBN
1741:PMID
1684:PMID
1635:PMID
1594:PMID
1584:ISBN
1545:PMID
1502:PMID
1467:PMID
1418:PMID
1238:Nogo
786:4099
377:pons
320:Bgee
268:Band
229:Chr.
167:Band
126:Chr.
80:1771
60:OMIM
2906:HFE
2487:SAG
2103:doi
2054:doi
2042:297
1997:doi
1950:doi
1907:doi
1870:doi
1829:PMC
1821:doi
1764:doi
1731:PMC
1723:doi
1674:PMC
1666:doi
1662:138
1625:doi
1621:276
1576:doi
1537:doi
1494:doi
1457:doi
1410:doi
1406:100
1276:NgR
1242:NgR
1234:NgR
1175:CNS
1167:PNS
1155:NgR
493:n/a
290:End
189:End
92:OMA
88:MAG
68:MGI
47:MAG
24:MAG
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