1216:
6% helical and 43% beta sheet: there are three short helical segments and ten beta strands. The beta strands are within two antiparallel beta sheets that form an immunoglobulin-like beta-sandwich fold. Several features of the protein structure suggest MOG has a role as an "adhesin in the completion and/or compaction of the myelin sheath." There is a "significant strip" of electronegative charge beginning near the N-terminus and running about half the length of the molecule. Also, MOG was shown to dimerize in solution, and the shape complementarity index is high at the dimer interface, suggesting a "biologically relevant MOG dimer."
299:
276:
173:
198:
2616:
305:
204:
26:
1190:, and is found exclusively in the CNS. "A single Ig-domain is exposed to the extracellular space" and consequently allows autoantibodies easy access. and therefore is easily accessible to autoantibodies too. The MOG "primary nuclear transcript … is 15,561 nucleotides in length" and, for humans, it has eight
1305:
models, have shown that "MOG-specific EAE models (of different animal strains) display/mirror human multiple sclerosis", but basically explains the part involved in the optic neuritis. These models with anti-MOG antibodies have been investigated extensively and are considered the only antibodies with
1215:
The crystal structure of myelin oligodendrocyte glycoprotein was determined by x-ray diffraction at a resolution of 1.45 Angstroms, using protein from the Norway rat. This protein is 139 residues long, and is a member of the immunoglobulin superfamily. The dssp secondary structure of the protein is
2497:
Baumann M, Hennes EM, Schanda K, Karenfort M, Kornek B, Seidl R, Diepold K, Lauffer H, Marquardt I, Strautmanis J, Syrbe S, Vieker S, Höftberger R, Reindl M, Rostásy K (2016). "Children with multiphasic disseminated encephalomyelitis and antibodies to the myelin oligodendrocyte glycoprotein (MOG):
1151:
While the primary molecular function of MOG is not yet known, its likely role with the myelin sheath is either in sheath "completion and/or maintenance". More specifically, MOG is speculated to be "necessary" as an "adhesion molecule" on the myelin sheath of the CNS to provide the structural
52:
1384:
ENSG00000232641, ENSG00000137345, ENSG00000230885, ENSG00000236561, ENSG00000237834, ENSG00000204655, ENSG00000234623 GRCh38: Ensembl release 89: ENSG00000234096, ENSG00000232641, ENSG00000137345, ENSG00000230885, ENSG00000236561, ENSG00000237834, ENSG00000204655,
1493:
Pham-Dinh D, Jones EP, Pitiot G, Della
Gaspera B, Daubas P, Mallet J, Le Paslier D, Fischer Lindahl K, Dautigny A (1995). "Physical mapping of the human and mouse MOG gene at the distal end of the MHC class Ib region".
1552:
Roth MP, Malfroy L, Offer C, Sevin J, Enault G, Borot N, Pontarotti P, Coppin H (July 1995). "The human myelin oligodendrocyte glycoprotein (MOG) gene: complete nucleotide sequence and structural characterization".
2156:
Ketelslegers IA, Van Pelt DE, Bryde S, Neuteboom RF, Catsman-Berrevoets CE, Hamann D, Hintzen RQ (October 2015). "Anti-MOG antibodies plead against MS diagnosis in an
Acquired Demyelinating Syndromes cohort".
2200:
Kitley J, Woodhall M, Waters P, Leite MI, Devenney E, Craig J, Palace J, Vincent A (September 2012). "Myelin-oligodendrocyte glycoprotein antibodies in adults with a neuromyelitis optica phenotype".
1608:
Pham-Dinh D, Allinquant B, Ruberg M, Della
Gaspera B, Nussbaum JL, Dautigny A (December 1994). "Characterization and expression of the cDNA coding for the human myelin/oligodendrocyte glycoprotein".
1458:
Pham-Dinh D, Della
Gaspera B, Kerlero de Rosbo N, Dautigny A (September 1995). "Structure of the human myelin/oligodendrocyte glycoprotein gene and multiple alternative spliced isoforms".
1159:
coding region in humans have been shown to be "highly homologous" to rats, mice, and bovine, and hence highly conserved. This suggests "an important biological role for this protein".
2656:
2448:
Spadaro M, Gerdes LA, Mayer MC, Ertl-Wagner B, Laurent S, Krumbholz M, Breithaupt C, Högen T, Straube A, Giese A, Hohlfeld R, Lassmann H, Meinl E, Kümpfel T (March 2015).
1290:). The proper way to identify it is by microarray, reacting patient serum with living cells, and detecting the binding IgG via a fluorescent-labeled secondary antibody.
312:
211:
1909:
Murzin AG, Brenner SE, Hubbard T, Chothia C (April 1995). "SCOP: a structural classification of proteins database for the investigation of sequences and structures".
3090:
1246:
3150:
2649:
1139:. It is speculated to serve as a necessary "adhesion molecule" to provide structural integrity to the myelin sheath and is known to develop late on the
134:
744:
725:
2886:
2881:
2615:
1299:
1309:
Anti-MOG antibodies have been shown to behave similarly to AQP4 antibodies in animal models, and are considered a biomarker against the MS diagnosis
2294:
1653:"Myelin/oligodendrocyte glycoprotein is a member of a subset of the immunoglobulin superfamily encoded within the major histocompatibility complex"
1866:
Kabsch W, Sander C (December 1983). "Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features".
2634:
2642:
2595:
1440:
2308:
Di Pauli F, Höftberger R, Reindl M, Beer R, Rhomberg P, Schanda K, Sato D, Fujihara K, Lassmann H, Schmutzhard E, Berger T (December 2015).
1422:
3170:
1353:
1330:
1258:
298:
2543:
1651:
Pham-Dinh D, Mattei MG, Nussbaum JL, Roussel G, Pontarotti P, Roeckel N, Mather IH, Artzt K, Lindahl KF, Dautigny A (September 1993).
1057:
1050:
275:
1760:"Splice variation in the cytoplasmic domains of myelin oligodendrocyte glycoprotein affects its cellular localisation and transport"
2405:
Reindl M, Di Pauli F, Rostásy K, Berger T (August 2013). "The spectrum of MOG autoantibody-associated demyelinating diseases".
2243:
Pröbstel AK, Rudolf G, Dornmair K, Collongues N, Chanson JB, Sanderson NS, Lindberg RL, Kappos L, de Seze J, Derfuss T (2015).
1409:
1388:
1306:
demyelinating capacity but again, EAE pathology is closer to NMO and ADEM than to the confluent demyelination observed in MS.
2858:
1405:
197:
172:
49:
1383:
1204:] DNA" sequences, among which are "14 Alu sequences within 3 introns", and have a range varying from 242 to 6484 bp.
1187:
114:
1263:
MOG has received much of its laboratory attention in studies dealing with MS. Several studies have shown a role for
2841:
311:
210:
2054:"Antimyelin antibodies as a predictor of clinically definite multiple sclerosis after a first demyelinating event"
2588:
2357:
Berger T, Reindl M (August 2015). "Antibody biomarkers in CNS demyelinating diseases - a long and winding road".
304:
203:
819:
122:
2052:
Berger T, Rubner P, Schautzer F, Egg R, Ulmer H, Mayringer I, Dilitz E, Deisenhammer F, Reindl M (July 2003).
3122:
1715:
Berger T, Reindl M (August 2007). "Multiple sclerosis: disease biomarkers as indicated by pathophysiology".
800:
796:
792:
782:
778:
774:
770:
766:
3175:
1944:
Clements CS, Reid HH, Beddoe T, Tynan FE, Perugini MA, Johns TG, Bernard CC, Rossjohn J (September 2003).
1238:
1129:
2846:
2673:
2107:
Kezuka T, Usui Y, Yamakawa N, Matsunaga Y, Matsuda R, Masuda M, Utsumi H, Tanaka K, Goto H (June 2012).
1172:
1946:"The crystal structure of myelin oligodendrocyte glycoprotein, a key autoantigen in multiple sclerosis"
1598:
Berger, T., Innsbruck
Medical University Dept. of Neurology interviewed by S. Gillooly, Nov. 24, 2008.
2873:
2829:
2723:
2581:
1957:
1820:
1664:
1318:
1272:
1242:
1168:
186:
2005:"Identification of the myelin oligodendrocyte glycoprotein as a cellular receptor for rubella virus"
1345:
Most cases of aquaporin-4-seronegative neuromyelitis optica: NMO derived from an antiMOG associated
101:
2863:
1012:
978:
974:
970:
929:
891:
887:
883:
2523:
2430:
2382:
2245:"Anti-MOG antibodies are present in a subgroup of patients with a neuromyelitis optica phenotype"
2225:
2182:
2138:
1891:
1740:
1633:
1519:
146:
1033:
1008:
1004:
1000:
996:
986:
982:
950:
925:
921:
917:
913:
909:
899:
895:
2293:
CYNTHIA MCKELVEY, Press Report, What's the Role of Myelin
Oligodendrocyte Glycoprotein in NMO?
2553:
2515:
2479:
2422:
2374:
2339:
2310:"Fulminant demyelinating encephalomyelitis: Insights from antibody studies and neuropathology"
2276:
2217:
2174:
2130:
2092:
Ichiro
Nakashima, Anti-myelin oligodendrocyte glycoprotein antibody in demyelinating diseases
2075:
2034:
1985:
1926:
1883:
1848:
1789:
1732:
1692:
1625:
1570:
1511:
1475:
1346:
94:
42:
3069:
3064:
3009:
2999:
2994:
2984:
2979:
2974:
2954:
2093:
3095:
2924:
2904:
2811:
2806:
2801:
2796:
2791:
2786:
2776:
2766:
2761:
2751:
2746:
2669:
2507:
2469:
2461:
2414:
2366:
2329:
2321:
2266:
2256:
2209:
2166:
2120:
2065:
2024:
2016:
1975:
1965:
1918:
1875:
1838:
1828:
1779:
1771:
1724:
1682:
1672:
1617:
1562:
1503:
1467:
391:
322:
266:
221:
2781:
2756:
1807:
Breithaupt C, Schubart A, Zander H, Skerra A, Huber R, Linington C, Jacob U (August 2003).
2708:
2703:
1341:
The presence of anti-MOG autoantibodies has been associated with the following conditions
1179:
1175:
1140:
366:
142:
1961:
1824:
1668:
1621:
2474:
2449:
2334:
2309:
2271:
2244:
2029:
2004:
1784:
1759:
1322:
1980:
1945:
1922:
1843:
1808:
1224:
Developmentally, MOG is formed "very late on oligodendrocytes and the myelin sheath".
659:
654:
649:
644:
639:
634:
618:
613:
608:
603:
587:
582:
3164:
2562:
1775:
1687:
1652:
1183:
569:
2527:
2386:
2186:
2142:
1895:
1744:
2681:
2434:
1637:
1523:
1268:
1117:
384:
163:
2229:
1809:"Structural insights into the antigenicity of myelin oligodendrocyte glycoprotein"
126:
2450:"Histopathology and clinical course of MOG-antibody-associated encephalomyelitis"
2325:
2213:
2125:
2108:
150:
3034:
2896:
1445:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1427:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1287:
1950:
Proceedings of the
National Academy of Sciences of the United States of America
1813:
Proceedings of the National Academy of Sciences of the United States of America
1657:
Proceedings of the National Academy of Sciences of the United States of America
1333:. MOG antibodies in NMOSD are variable depending on the seropositivity status.
467:
3117:
3100:
2698:
2418:
2261:
1728:
1283:
1264:
1212:
Alternatively spliced human mRNA of the MOG gene form at least nine isoforms.
283:
180:
130:
2511:
2170:
3127:
1970:
1833:
1677:
1326:
689:
527:
405:
350:
337:
249:
236:
138:
2519:
2483:
2426:
2378:
2343:
2280:
2221:
2178:
2134:
2109:"Relationship between NMO-antibody and anti-MOG antibody in optic neuritis"
2079:
2038:
1989:
1852:
1793:
1736:
1566:
1471:
1930:
1887:
1879:
1696:
1629:
1574:
1515:
1479:
1097:
1092:
3085:
2690:
2070:
2053:
2020:
1081:
864:
845:
1758:
Boyle LH, Traherne JA, Plotnek G, Ward R, Trowsdale J (September 2007).
3059:
3054:
3014:
3004:
2989:
2969:
2964:
2959:
2949:
2665:
2567:
2557:
1507:
1195:
831:
756:
2370:
71:
2944:
2939:
2934:
2929:
2919:
2914:
2909:
2821:
2677:
2465:
1121:
1065:
711:
25:
105:, BTN6, BTNL11, MOGIG2, NRCLP7, myelin oligodendrocyte glycoprotein
3110:
3105:
3019:
2771:
2741:
2736:
1279:
1191:
1125:
1278:
Anti-MOG status is different depending whether it is measured by
674:
670:
3137:
3132:
3049:
3039:
3029:
3024:
2834:
2731:
2713:
2547:
1271:
of MS, though most of them were written before the discovery of
1156:
1136:
118:
2638:
2624:: The crystal structure of an autoantigen in multiple sclerosis
2577:
1356:, specially the recurrent ones (MDEM) and the fulminant courses
3044:
2573:
1200:
2552:
Overview of all the structural information available in the
1317:
Anti-MOG autoimmunity has been found to be involved in most
2498:
Extending the spectrum of MOG antibody positive diseases".
374:
1253:
Anti-MOG associated inflammatory demyelinating diseases
2500:
Multiple Sclerosis (Houndmills, Basingstoke, England)
1198:". The introns "contain numerous reptitive [
539:
3078:
2895:
2872:
2820:
2722:
2689:
2566:(Mouse Myelin-oligodendrocyte glycoprotein) at the
1026:
969:
943:
882:
2314:Neurology: Neuroimmunology & Neuroinflammation
1401:
1399:
1397:
1379:
1377:
1375:
1171:p21.3-p22, was first sequenced in 1995. It is a
1132:(CNS). In humans this protein is encoded by the
321:
220:
3091:LDL-receptor-related protein-associated protein
2454:Annals of Clinical and Translational Neurology
1406:GRCm38: Ensembl release 89: ENSMUSG00000076439
1362:isolated optic neuritis or transverse myelitis
2650:
2589:
1241:. Some of them are not-inflammatory, such as
8:
1237:Interest in MOG has centered on its role in
1594:
1592:
1590:
1588:
1586:
1584:
2657:
2643:
2635:
2596:
2582:
2574:
2303:
2301:
1710:
1708:
1706:
1249:, and Rubella induced mental retardation.
966:
879:
761:
685:
565:
362:
261:
158:
60:
2887:Pulmonary surfactant-associated protein C
2882:Pulmonary surfactant-associated protein B
2473:
2400:
2398:
2396:
2333:
2270:
2260:
2124:
2102:
2100:
2069:
2028:
2003:Cong H, Jiang Y, Tien P (November 2011).
1979:
1969:
1842:
1832:
1783:
1686:
1676:
1301:Experimental Autoimmune Encephalomyelitis
2611:
1371:
1233:Non-inflammatory demyelinating diseases
1547:
1545:
1543:
1541:
1539:
1537:
1535:
1533:
15:
3151:other cell membrane protein disorders
326:
287:
282:
225:
184:
179:
7:
1717:Journal of the Neurological Sciences
1354:acute disseminated encephalomyelitis
1313:In seronegative neuromyelitis optica
1259:antiMOG associated encephalomyelitis
2854:Myelin oligodendrocyte glycoprotein
2544:Online Mendelian Inheritance in Man
2058:The New England Journal of Medicine
1622:10.1046/j.1471-4159.1994.63062353.x
1110:Myelin oligodendrocyte glycoprotein
1275:and the NMO spectrum of diseases.
1186:. "MOG is a quantitatively minor
1023:
940:
855:
836:
810:
735:
716:
635:central nervous system development
544:
506:central gray substance of midbrain
462:
400:
379:
14:
1152:integrity of the myelin sheath."
660:T cell receptor signaling pathway
2614:
1776:10.1111/j.1471-4159.2007.04687.x
1359:Some cases of multiple sclerosis
1182:and on the outermost surface of
1120:believed to be important in the
619:external side of plasma membrane
482:lumbar subsegment of spinal cord
310:
303:
297:
274:
209:
202:
196:
171:
24:
3123:Phospholipid transfer proteins
2859:Myelin-associated glycoprotein
2113:Journal of Neuro-Ophthalmology
1247:vanishing white matter disease
1194:which are "separated by seven
604:integral component of membrane
528:More reference expression data
1:
2359:European Journal of Neurology
1923:10.1016/S0022-2836(05)80134-2
655:regulation of immune response
295:
194:
2326:10.1212/NXI.0000000000000175
2249:Journal of Neuroinflammation
2214:10.1212/WNL.0b013e31826aac4e
2126:10.1097/WNO.0b013e31823c9b6c
1911:Journal of Molecular Biology
1298:Animal models of MS, namely
1188:type I transmembrane protein
3171:Genes on human chromosome 6
1167:The gene for MOG, found on
510:nucleus of stria terminalis
3192:
2842:Myelin proteolipid protein
1256:
640:viral entry into host cell
588:signaling receptor binding
486:lateral geniculate nucleus
3146:
2609:
2419:10.1038/nrneurol.2013.118
2407:Nature Reviews. Neurology
2262:10.1186/s12974-015-0256-1
1764:Journal of Neurochemistry
1729:10.1016/j.jns.2006.05.070
1610:Journal of Neurochemistry
1441:"Mouse PubMed Reference:"
1423:"Human PubMed Reference:"
1096:
1091:
1087:
1080:
1064:
1045:
1030:
993:
962:
947:
906:
875:
862:
858:
843:
839:
830:
817:
813:
790:
764:
755:
742:
738:
723:
719:
710:
695:
688:
684:
668:
568:
564:
552:
547:
538:
525:
502:medial geniculate nucleus
474:
465:
412:
403:
373:
365:
361:
344:
331:
294:
273:
264:
260:
243:
230:
193:
170:
161:
157:
112:
109:
99:
92:
87:
68:
63:
46:
41:
36:
32:
23:
18:
2512:10.1177/1352458516631038
2171:10.1177/1352458514566666
1058:Chr 17: 37.32 – 37.33 Mb
514:dorsal tegmental nucleus
1971:10.1073/pnas.1833158100
1834:10.1073/pnas.1133443100
1678:10.1073/pnas.90.17.7990
1051:Chr 6: 29.66 – 29.67 Mb
583:virus receptor activity
1567:10.1006/geno.1995.1137
1472:10.1006/geno.1995.9995
1239:demyelinating diseases
1130:central nervous system
494:ventral tegmental area
478:deep cerebellar nuclei
328:17 B1|17 19.16 cM
2674:Cell surface receptor
1880:10.1002/bip.360221211
1319:AQP4-seronegative NMO
1173:transmembrane protein
432:primary visual cortex
289:Chromosome 17 (mouse)
2874:Pulmonary surfactant
2830:Myelin basic protein
2724:Membrane-spanning 4A
2071:10.1056/NEJMoa022328
2021:10.1128/JVI.05398-11
1243:adrenoleukodystrophy
1180:oligodendrocyte cell
187:Chromosome 6 (human)
64:List of PDB id codes
37:Available structures
2864:Myelin protein zero
2009:Journal of Virology
1962:2003PNAS..10011059C
1825:2003PNAS..100.9446B
1669:1993PNAS...90.7990P
1337:In other conditions
1267:against MOG in the
2159:Multiple Sclerosis
1508:10.1007/bf00179400
1178:on the surface of
1147:Molecular function
820:ENSMUSG00000076439
628:Biological process
597:Cellular component
576:Molecular function
424:hippocampus proper
3158:
3157:
2670:membrane proteins
2632:
2631:
2506:(14): 1821–1829.
2371:10.1111/ene.12759
1347:encephalomyelitis
1107:
1106:
1103:
1102:
1076:
1075:
1041:
1040:
1020:
1019:
958:
957:
937:
936:
871:
870:
852:
851:
826:
825:
807:
806:
751:
750:
732:
731:
680:
679:
560:
559:
556:
555:
534:
533:
521:
520:
459:
458:
357:
356:
256:
255:
83:
82:
79:
78:
47:Ortholog search:
3183:
2659:
2652:
2645:
2636:
2618:
2598:
2591:
2584:
2575:
2532:
2531:
2494:
2488:
2487:
2477:
2466:10.1002/acn3.164
2445:
2439:
2438:
2402:
2391:
2390:
2354:
2348:
2347:
2337:
2305:
2296:
2291:
2285:
2284:
2274:
2264:
2240:
2234:
2233:
2197:
2191:
2190:
2153:
2147:
2146:
2128:
2104:
2095:
2090:
2084:
2083:
2073:
2049:
2043:
2042:
2032:
2015:(21): 11038–47.
2000:
1994:
1993:
1983:
1973:
1956:(19): 11059–64.
1941:
1935:
1934:
1906:
1900:
1899:
1874:(12): 2577–637.
1863:
1857:
1856:
1846:
1836:
1804:
1798:
1797:
1787:
1755:
1749:
1748:
1712:
1701:
1700:
1690:
1680:
1648:
1642:
1641:
1605:
1599:
1596:
1579:
1578:
1549:
1528:
1527:
1490:
1484:
1483:
1455:
1449:
1448:
1437:
1431:
1430:
1419:
1413:
1403:
1392:
1381:
1294:In animal models
1089:
1088:
1060:
1053:
1036:
1024:
1015:
967:
963:RefSeq (protein)
953:
941:
932:
880:
856:
837:
811:
786:
762:
736:
717:
686:
566:
545:
530:
470:
468:Top expressed in
463:
420:substantia nigra
408:
406:Top expressed in
401:
380:
363:
353:
340:
329:
314:
307:
301:
290:
278:
262:
252:
239:
228:
213:
206:
200:
189:
175:
159:
153:
104:
97:
74:
61:
55:
34:
33:
28:
16:
3191:
3190:
3186:
3185:
3184:
3182:
3181:
3180:
3161:
3160:
3159:
3154:
3142:
3096:Neurofibromin 2
3079:Other/ungrouped
3074:
2891:
2868:
2816:
2718:
2685:
2663:
2633:
2628:
2625:
2619:
2605:
2602:
2540:
2535:
2496:
2495:
2491:
2447:
2446:
2442:
2404:
2403:
2394:
2356:
2355:
2351:
2307:
2306:
2299:
2292:
2288:
2242:
2241:
2237:
2199:
2198:
2194:
2165:(12): 1513–20.
2155:
2154:
2150:
2106:
2105:
2098:
2091:
2087:
2051:
2050:
2046:
2002:
2001:
1997:
1943:
1942:
1938:
1908:
1907:
1903:
1865:
1864:
1860:
1819:(16): 9446–51.
1806:
1805:
1801:
1757:
1756:
1752:
1714:
1713:
1704:
1650:
1649:
1645:
1607:
1606:
1602:
1597:
1582:
1551:
1550:
1531:
1492:
1491:
1487:
1457:
1456:
1452:
1439:
1438:
1434:
1421:
1420:
1416:
1404:
1395:
1385:ENSG00000234623
1382:
1373:
1369:
1339:
1315:
1296:
1261:
1255:
1235:
1230:
1228:Role in disease
1222:
1210:
1165:
1149:
1141:oligodendrocyte
1098:View/Edit Mouse
1093:View/Edit Human
1056:
1049:
1046:Location (UCSC)
1032:
1011:
1007:
1003:
999:
995:
989:
985:
981:
977:
973:
949:
928:
924:
920:
916:
912:
908:
902:
898:
894:
890:
886:
801:ENSG00000234623
799:
797:ENSG00000204655
795:
793:ENSG00000237834
785:
783:ENSG00000236561
781:
779:ENSG00000230885
777:
775:ENSG00000137345
773:
771:ENSG00000232641
769:
767:ENSG00000234096
765:
664:
623:
609:plasma membrane
592:
526:
517:
512:
508:
504:
500:
496:
492:
490:globus pallidus
488:
484:
480:
466:
455:
452:corpus callosum
450:
448:Brodmann area 9
446:
444:caudate nucleus
442:
438:
434:
430:
426:
422:
418:
404:
348:
335:
327:
317:
316:
315:
308:
288:
265:Gene location (
247:
234:
226:
216:
215:
214:
207:
185:
162:Gene location (
151:MOG - orthologs
113:
100:
93:
70:
48:
12:
11:
5:
3189:
3187:
3179:
3178:
3173:
3163:
3162:
3156:
3155:
3147:
3144:
3143:
3141:
3140:
3135:
3130:
3125:
3120:
3115:
3114:
3113:
3108:
3098:
3093:
3088:
3082:
3080:
3076:
3075:
3073:
3072:
3067:
3062:
3057:
3052:
3047:
3042:
3037:
3032:
3027:
3022:
3017:
3012:
3007:
3002:
2997:
2992:
2987:
2982:
2977:
2972:
2967:
2962:
2957:
2952:
2947:
2942:
2937:
2932:
2927:
2922:
2917:
2912:
2907:
2901:
2899:
2893:
2892:
2890:
2889:
2884:
2878:
2876:
2870:
2869:
2867:
2866:
2861:
2856:
2851:
2850:
2849:
2839:
2838:
2837:
2826:
2824:
2818:
2817:
2815:
2814:
2809:
2804:
2799:
2794:
2789:
2784:
2779:
2774:
2769:
2764:
2759:
2754:
2749:
2744:
2739:
2734:
2728:
2726:
2720:
2719:
2717:
2716:
2711:
2706:
2701:
2695:
2693:
2687:
2686:
2664:
2662:
2661:
2654:
2647:
2639:
2630:
2629:
2627:
2626:
2620:
2613:
2610:
2607:
2606:
2603:
2601:
2600:
2593:
2586:
2578:
2572:
2571:
2550:
2539:
2538:External links
2536:
2534:
2533:
2489:
2460:(3): 295–301.
2440:
2392:
2349:
2297:
2286:
2235:
2208:(12): 1273–7.
2192:
2148:
2096:
2085:
2044:
1995:
1936:
1901:
1858:
1799:
1770:(6): 1853–62.
1750:
1702:
1663:(17): 7990–4.
1643:
1600:
1580:
1529:
1496:Immunogenetics
1485:
1450:
1432:
1414:
1393:
1370:
1368:
1365:
1364:
1363:
1360:
1357:
1352:Some cases of
1350:
1338:
1335:
1323:optic neuritis
1314:
1311:
1295:
1292:
1257:Main article:
1254:
1251:
1234:
1231:
1229:
1226:
1221:
1218:
1209:
1206:
1184:myelin sheaths
1164:
1161:
1148:
1145:
1105:
1104:
1101:
1100:
1095:
1085:
1084:
1078:
1077:
1074:
1073:
1071:
1069:
1062:
1061:
1054:
1047:
1043:
1042:
1039:
1038:
1028:
1027:
1021:
1018:
1017:
991:
990:
964:
960:
959:
956:
955:
945:
944:
938:
935:
934:
904:
903:
877:
873:
872:
869:
868:
860:
859:
853:
850:
849:
841:
840:
834:
828:
827:
824:
823:
815:
814:
808:
805:
804:
788:
787:
759:
753:
752:
749:
748:
740:
739:
733:
730:
729:
721:
720:
714:
708:
707:
702:
697:
693:
692:
682:
681:
678:
677:
666:
665:
663:
662:
657:
652:
647:
642:
637:
631:
629:
625:
624:
622:
621:
616:
611:
606:
600:
598:
594:
593:
591:
590:
585:
579:
577:
573:
572:
562:
561:
558:
557:
554:
553:
550:
549:
542:
536:
535:
532:
531:
523:
522:
519:
518:
516:
515:
511:
507:
503:
499:
498:pontine nuclei
495:
491:
487:
483:
479:
475:
472:
471:
460:
457:
456:
454:
453:
449:
445:
441:
437:
433:
429:
425:
421:
417:
413:
410:
409:
397:
396:
388:
377:
371:
370:
367:RNA expression
359:
358:
355:
354:
346:
342:
341:
333:
330:
325:
319:
318:
309:
302:
296:
292:
291:
286:
280:
279:
271:
270:
258:
257:
254:
253:
245:
241:
240:
232:
229:
224:
218:
217:
208:
201:
195:
191:
190:
183:
177:
176:
168:
167:
155:
154:
111:
107:
106:
98:
90:
89:
85:
84:
81:
80:
77:
76:
66:
65:
57:
56:
45:
39:
38:
30:
29:
21:
20:
13:
10:
9:
6:
4:
3:
2:
3188:
3177:
3176:Glycoproteins
3174:
3172:
3169:
3168:
3166:
3153:
3152:
3145:
3139:
3136:
3134:
3131:
3129:
3126:
3124:
3121:
3119:
3116:
3112:
3109:
3107:
3104:
3103:
3102:
3099:
3097:
3094:
3092:
3089:
3087:
3084:
3083:
3081:
3077:
3071:
3068:
3066:
3063:
3061:
3058:
3056:
3053:
3051:
3048:
3046:
3043:
3041:
3038:
3036:
3033:
3031:
3028:
3026:
3023:
3021:
3018:
3016:
3013:
3011:
3008:
3006:
3003:
3001:
2998:
2996:
2993:
2991:
2988:
2986:
2983:
2981:
2978:
2976:
2973:
2971:
2968:
2966:
2963:
2961:
2958:
2956:
2953:
2951:
2948:
2946:
2943:
2941:
2938:
2936:
2933:
2931:
2928:
2926:
2923:
2921:
2918:
2916:
2913:
2911:
2908:
2906:
2903:
2902:
2900:
2898:
2894:
2888:
2885:
2883:
2880:
2879:
2877:
2875:
2871:
2865:
2862:
2860:
2857:
2855:
2852:
2848:
2845:
2844:
2843:
2840:
2836:
2833:
2832:
2831:
2828:
2827:
2825:
2823:
2819:
2813:
2810:
2808:
2805:
2803:
2800:
2798:
2795:
2793:
2790:
2788:
2785:
2783:
2780:
2778:
2775:
2773:
2770:
2768:
2765:
2763:
2760:
2758:
2755:
2753:
2750:
2748:
2745:
2743:
2740:
2738:
2735:
2733:
2730:
2729:
2727:
2725:
2721:
2715:
2712:
2710:
2707:
2705:
2702:
2700:
2697:
2696:
2694:
2692:
2688:
2683:
2679:
2675:
2671:
2667:
2660:
2655:
2653:
2648:
2646:
2641:
2640:
2637:
2623:
2617:
2612:
2608:
2599:
2594:
2592:
2587:
2585:
2580:
2579:
2576:
2569:
2565:
2564:
2559:
2555:
2551:
2549:
2545:
2542:
2541:
2537:
2529:
2525:
2521:
2517:
2513:
2509:
2505:
2501:
2493:
2490:
2485:
2481:
2476:
2471:
2467:
2463:
2459:
2455:
2451:
2444:
2441:
2436:
2432:
2428:
2424:
2420:
2416:
2413:(8): 455–61.
2412:
2408:
2401:
2399:
2397:
2393:
2388:
2384:
2380:
2376:
2372:
2368:
2365:(8): 1162–8.
2364:
2360:
2353:
2350:
2345:
2341:
2336:
2331:
2327:
2323:
2319:
2315:
2311:
2304:
2302:
2298:
2295:
2290:
2287:
2282:
2278:
2273:
2268:
2263:
2258:
2254:
2250:
2246:
2239:
2236:
2231:
2227:
2223:
2219:
2215:
2211:
2207:
2203:
2196:
2193:
2188:
2184:
2180:
2176:
2172:
2168:
2164:
2160:
2152:
2149:
2144:
2140:
2136:
2132:
2127:
2122:
2119:(2): 107–10.
2118:
2114:
2110:
2103:
2101:
2097:
2094:
2089:
2086:
2081:
2077:
2072:
2067:
2064:(2): 139–45.
2063:
2059:
2055:
2048:
2045:
2040:
2036:
2031:
2026:
2022:
2018:
2014:
2010:
2006:
1999:
1996:
1991:
1987:
1982:
1977:
1972:
1967:
1963:
1959:
1955:
1951:
1947:
1940:
1937:
1932:
1928:
1924:
1920:
1917:(4): 536–40.
1916:
1912:
1905:
1902:
1897:
1893:
1889:
1885:
1881:
1877:
1873:
1869:
1862:
1859:
1854:
1850:
1845:
1840:
1835:
1830:
1826:
1822:
1818:
1814:
1810:
1803:
1800:
1795:
1791:
1786:
1781:
1777:
1773:
1769:
1765:
1761:
1754:
1751:
1746:
1742:
1738:
1734:
1730:
1726:
1723:(1–2): 21–6.
1722:
1718:
1711:
1709:
1707:
1703:
1698:
1694:
1689:
1684:
1679:
1674:
1670:
1666:
1662:
1658:
1654:
1647:
1644:
1639:
1635:
1631:
1627:
1623:
1619:
1616:(6): 2353–6.
1615:
1611:
1604:
1601:
1595:
1593:
1591:
1589:
1587:
1585:
1581:
1576:
1572:
1568:
1564:
1561:(2): 241–50.
1560:
1556:
1548:
1546:
1544:
1542:
1540:
1538:
1536:
1534:
1530:
1525:
1521:
1517:
1513:
1509:
1505:
1502:(5): 386–91.
1501:
1497:
1489:
1486:
1481:
1477:
1473:
1469:
1466:(2): 345–52.
1465:
1461:
1454:
1451:
1446:
1442:
1436:
1433:
1428:
1424:
1418:
1415:
1411:
1407:
1402:
1400:
1398:
1394:
1390:
1386:
1380:
1378:
1376:
1372:
1366:
1361:
1358:
1355:
1351:
1348:
1344:
1343:
1342:
1336:
1334:
1332:
1328:
1324:
1320:
1312:
1310:
1307:
1304:
1302:
1293:
1291:
1289:
1285:
1281:
1276:
1274:
1270:
1266:
1260:
1252:
1250:
1248:
1244:
1240:
1232:
1227:
1225:
1219:
1217:
1213:
1207:
1205:
1203:
1202:
1197:
1193:
1189:
1185:
1181:
1177:
1174:
1170:
1162:
1160:
1158:
1153:
1146:
1144:
1142:
1138:
1135:
1131:
1127:
1123:
1119:
1115:
1111:
1099:
1094:
1090:
1086:
1083:
1079:
1072:
1070:
1067:
1063:
1059:
1055:
1052:
1048:
1044:
1037:
1035:
1029:
1025:
1022:
1016:
1014:
1010:
1006:
1002:
998:
992:
988:
984:
980:
976:
972:
968:
965:
961:
954:
952:
946:
942:
939:
933:
931:
927:
923:
919:
915:
911:
905:
901:
897:
893:
889:
885:
881:
878:
876:RefSeq (mRNA)
874:
867:
866:
861:
857:
854:
848:
847:
842:
838:
835:
833:
829:
822:
821:
816:
812:
809:
803:
802:
798:
794:
789:
784:
780:
776:
772:
768:
763:
760:
758:
754:
747:
746:
741:
737:
734:
728:
727:
722:
718:
715:
713:
709:
706:
703:
701:
698:
694:
691:
687:
683:
676:
672:
667:
661:
658:
656:
653:
651:
650:viral process
648:
646:
645:cell adhesion
643:
641:
638:
636:
633:
632:
630:
627:
626:
620:
617:
615:
612:
610:
607:
605:
602:
601:
599:
596:
595:
589:
586:
584:
581:
580:
578:
575:
574:
571:
570:Gene ontology
567:
563:
551:
546:
543:
541:
537:
529:
524:
513:
509:
505:
501:
497:
493:
489:
485:
481:
477:
476:
473:
469:
464:
461:
451:
447:
443:
439:
436:temporal lobe
435:
431:
427:
423:
419:
415:
414:
411:
407:
402:
399:
398:
395:
393:
389:
387:
386:
382:
381:
378:
376:
372:
368:
364:
360:
352:
347:
343:
339:
334:
324:
320:
313:
306:
300:
293:
285:
281:
277:
272:
268:
263:
259:
251:
246:
242:
238:
233:
223:
219:
212:
205:
199:
192:
188:
182:
178:
174:
169:
165:
160:
156:
152:
148:
144:
140:
136:
132:
128:
124:
120:
116:
108:
103:
96:
91:
86:
75:
73:
67:
62:
59:
58:
54:
51:
44:
40:
35:
31:
27:
22:
17:
3148:
2853:
2682:cytoskeleton
2672:(other than
2621:
2561:
2503:
2499:
2492:
2457:
2453:
2443:
2410:
2406:
2362:
2358:
2352:
2317:
2313:
2289:
2252:
2248:
2238:
2205:
2201:
2195:
2162:
2158:
2151:
2116:
2112:
2088:
2061:
2057:
2047:
2012:
2008:
1998:
1953:
1949:
1939:
1914:
1910:
1904:
1871:
1867:
1861:
1816:
1812:
1802:
1767:
1763:
1753:
1720:
1716:
1660:
1656:
1646:
1613:
1609:
1603:
1558:
1554:
1499:
1495:
1488:
1463:
1459:
1453:
1444:
1435:
1426:
1417:
1340:
1321:and also in
1316:
1308:
1300:
1297:
1277:
1269:pathogenesis
1262:
1236:
1223:
1214:
1211:
1199:
1169:chromosome 6
1166:
1154:
1150:
1133:
1118:glycoprotein
1113:
1109:
1108:
1031:
1013:NP_001350539
994:
979:NP_001163889
975:NP_001008230
971:NP_001008229
948:
930:NM_001363610
907:
892:NM_001170418
888:NM_001008229
884:NM_001008228
863:
844:
818:
791:
743:
724:
704:
699:
390:
383:
110:External IDs
69:
2897:Tetraspanin
2604:PDB gallery
2320:(6): e175.
1868:Biopolymers
1122:myelination
349:37,334,290
336:37,321,635
248:29,672,372
235:29,657,002
88:Identifiers
3165:Categories
3101:Presenilin
1412:, May 2017
1391:, May 2017
1367:References
1284:microarray
1265:antibodies
1163:Physiology
416:C1 segment
394:(ortholog)
131:HomoloGene
3149:see also
3128:Dysferlin
2255:(1): 46.
2202:Neurology
1329:forms of
1327:fulminant
1325:and some
1220:Synthesis
1208:Structure
1176:expressed
1034:NP_034944
1009:NP_996537
1005:NP_996535
1001:NP_996534
997:NP_996533
987:NP_996532
983:NP_002424
951:NM_010814
926:NM_206814
922:NM_206813
918:NM_206812
914:NM_206811
910:NM_206810
900:NM_206809
896:NM_002433
690:Orthologs
139:GeneCards
3086:Calnexin
2691:Arrestin
2546:(OMIM):
2528:30428892
2520:26869530
2484:25815356
2427:23797245
2387:39301229
2379:26010364
2344:26587556
2281:25889963
2222:22914827
2187:25321614
2179:25662345
2143:46667141
2135:22157536
2080:12853586
2039:21880773
1990:12960396
1896:29185760
1853:12874380
1794:17573820
1745:23257594
1737:17367811
1555:Genomics
1460:Genomics
1408:–
1387:–
1082:Wikidata
669:Sources:
614:membrane
440:amygdala
3070:TSPAN34
3065:TSPAN33
3060:TSPAN32
3055:TSPAN31
3050:TSPAN30
3045:TSPAN29
3040:TSPAN28
3035:TSPAN27
3030:TSPAN26
3025:TSPAN25
3020:TSPAN24
3015:TSPAN23
3010:TSPAN22
3005:TSPAN21
3000:TSPAN20
2995:TSPAN19
2990:TSPAN18
2985:TSPAN17
2980:TSPAN16
2975:TSPAN15
2970:TSPAN14
2965:TSPAN13
2960:TSPAN12
2955:TSPAN11
2950:TSPAN10
2678:enzymes
2668:: cell
2666:Protein
2568:PDBe-KB
2558:UniProt
2475:4369279
2435:7219279
2335:4635550
2272:4359547
2030:3194935
1958:Bibcode
1931:7723011
1888:6667333
1821:Bibcode
1785:2156149
1697:8367453
1665:Bibcode
1638:2788720
1630:7964757
1575:8530032
1524:8310478
1516:7590972
1480:8666381
1410:Ensembl
1389:Ensembl
1273:NMO-IgG
1196:introns
1128:in the
1116:) is a
832:UniProt
757:Ensembl
696:Species
675:QuickGO
428:putamen
369:pattern
95:Aliases
2945:TSPAN9
2940:TSPAN8
2935:TSPAN7
2930:TSPAN6
2925:TSPAN5
2920:TSPAN4
2915:TSPAN3
2910:TSPAN2
2905:TSPAN1
2822:Myelin
2812:MS4A18
2807:MS4A15
2802:MS4A14
2797:MS4A13
2792:MS4A12
2787:MS4A10
2777:MS4A8B
2767:MS4A6E
2762:MS4A6A
2752:MS4A4E
2747:MS4A4A
2680:, and
2563:Q61885
2548:159465
2526:
2518:
2482:
2472:
2433:
2425:
2385:
2377:
2342:
2332:
2279:
2269:
2230:855313
2228:
2220:
2185:
2177:
2141:
2133:
2078:
2037:
2027:
1988:
1981:196926
1978:
1929:
1894:
1886:
1851:
1844:170938
1841:
1792:
1782:
1743:
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1636:
1628:
1573:
1522:
1514:
1478:
1282:or by
1155:MOG's
1126:nerves
1068:search
1066:PubMed
865:Q61885
846:Q16653
712:Entrez
540:BioGPS
227:6p22.1
135:111009
119:159465
3111:PSEN2
3106:PSEN1
2782:MS4A9
2772:MS4A7
2757:MS4A5
2742:MS4A3
2737:MS4A2
2732:MS4A1
2709:ARRB2
2704:ARRB1
2524:S2CID
2431:S2CID
2383:S2CID
2226:S2CID
2183:S2CID
2139:S2CID
1892:S2CID
1741:S2CID
1688:47273
1634:S2CID
1520:S2CID
1303:(EAE)
1280:ELISA
1192:exons
745:17441
705:Mouse
700:Human
671:Amigo
392:Mouse
385:Human
332:Start
267:Mouse
231:Start
164:Human
127:97435
3138:OTOF
3133:STRC
2847:PLP1
2835:PMP2
2714:ARR3
2622:1py9
2556:for
2516:PMID
2480:PMID
2423:PMID
2375:PMID
2340:PMID
2277:PMID
2218:PMID
2175:PMID
2131:PMID
2076:PMID
2035:PMID
1986:PMID
1927:PMID
1884:PMID
1849:PMID
1790:PMID
1733:PMID
1693:PMID
1626:PMID
1571:PMID
1512:PMID
1476:PMID
1331:ADEM
1157:cDNA
1137:gene
726:4340
375:Bgee
323:Band
284:Chr.
222:Band
181:Chr.
115:OMIM
72:1Q70
53:RCSB
50:PDBe
3118:HFE
2699:SAG
2554:PDB
2508:doi
2470:PMC
2462:doi
2415:doi
2367:doi
2330:PMC
2322:doi
2267:PMC
2257:doi
2210:doi
2167:doi
2121:doi
2066:doi
2062:349
2025:PMC
2017:doi
1976:PMC
1966:doi
1954:100
1919:doi
1915:247
1876:doi
1839:PMC
1829:doi
1817:100
1780:PMC
1772:doi
1768:102
1725:doi
1721:259
1683:PMC
1673:doi
1618:doi
1563:doi
1504:doi
1468:doi
1288:CBA
1201:sic
1134:MOG
1124:of
1114:MOG
548:n/a
345:End
244:End
147:OMA
143:MOG
123:MGI
102:MOG
43:PDB
19:MOG
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