310:
287:
184:
209:
1868:
316:
215:
29:
1090:
This protein is the human homolog of mastermind, a
Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase
55:
1512:
Zhao Y, Katzman RB, Delmolino LM, Bhat I, Zhang Y, Gurumurthy CB, Germaniuk-Kurowska A, Reddi HV, Solomon A, Zeng MS, Kung A, Ma H, Gao Q, Dimri G, Stanculescu A, Miele L, Wu L, Griffin JD, Wazer DE, Band H, Band V (2007).
1216:
Wu L, Aster JC, Blacklow SC, Lake R, Artavanis-Tsakonas S, Griffin JD (Dec 2000). "MAML1, a human homologue of
Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors".
1261:"A human protein with sequence similarity to Drosophila mastermind coordinates the nuclear form of notch and a CSL protein to build a transcriptional activator complex on target promoters"
1867:
323:
222:
805:
786:
145:
1091:
expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway.
1195:
1847:
1177:
1896:
1479:"Mastermind-like 1 Is a specific coactivator of beta-catenin transcription activation and is essential for colon carcinoma cell survival"
309:
1663:"p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro"
1327:"p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro"
1009:
1016:
286:
1311:
1514:
1164:
1143:
1160:
1706:"Identification of new human mastermind proteins defines a family that consists of positive regulators for notch signaling"
1628:"Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex"
208:
183:
52:
1139:
125:
1107:
322:
221:
315:
214:
1840:
850:
133:
831:
1425:"Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors"
1784:"SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation"
1550:"Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes"
1593:"Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover"
1833:
197:
112:
992:
1741:"Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex"
1579:
1376:"Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex"
1241:
1094:
Details on the activity of the N-terminal domain of
Mastermind-like protein 1 may be found under
157:
988:
967:
941:
920:
1813:
1770:
1727:
1692:
1649:
1614:
1571:
1536:
1500:
1454:
1405:
1356:
1290:
1233:
105:
45:
1803:
1795:
1782:
Wu G, Lyapina S, Das I, Li J, Gurney M, Pauley A, Chui I, Deshaies RJ, Kitajewski J (2001).
1760:
1752:
1717:
1682:
1674:
1639:
1604:
1561:
1526:
1490:
1444:
1436:
1395:
1387:
1346:
1338:
1280:
1272:
1225:
402:
333:
277:
232:
1259:
Kitagawa M, Oyama T, Kawashima T, Yedvobnick B, Kumar A, Matsuno K, Harigaya K (Jun 2001).
153:
377:
28:
1765:
1740:
1687:
1662:
1449:
1424:
1400:
1375:
1351:
1326:
720:
715:
710:
705:
700:
695:
690:
685:
680:
675:
670:
665:
660:
644:
639:
634:
629:
624:
608:
603:
598:
593:
1890:
1808:
1799:
1783:
1678:
1440:
1342:
1285:
1276:
1260:
1095:
580:
1583:
1245:
137:
1876:: Crystal structure of activated Notch, CSL and MAML on HES-1 promoter DNA sequence
395:
174:
1495:
1478:
1609:
1592:
161:
1200:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1182:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1566:
1549:
478:
294:
191:
141:
1515:"The notch regulator MAML1 interacts with p53 and functions as a coactivator"
750:
538:
416:
361:
348:
260:
247:
149:
1817:
1774:
1731:
1722:
1705:
1696:
1653:
1644:
1627:
1618:
1575:
1540:
1531:
1504:
1458:
1409:
1360:
1294:
1237:
1056:
1051:
1040:
895:
876:
1756:
1391:
1072:
862:
817:
82:
78:
74:
1115:
1024:
772:
1229:
1111:
1374:
Fryer CJ, Lamar E, Turbachova I, Kintner C, Jones KA (Jun 2002).
735:
731:
1079:
129:
1829:
1825:
1739:
Fryer CJ, Lamar E, Turbachova I, Kintner C, Jones KA (2002).
716:
positive regulation of transcription of Notch receptor target
116:, Mam-1, Mam1, mastermind like transcriptional coactivator 1
1704:
Lin SE, Oyama T, Nagase T, Harigaya K, Kitagawa M (2003).
1325:
Wallberg AE, Pedersen K, Lendahl U, Roeder RG (Nov 2002).
711:
positive regulation of transcription by RNA polymerase II
1423:
Wu L, Sun T, Kobayashi K, Gao P, Griffin JD (Nov 2002).
706:
transcription initiation from RNA polymerase II promoter
385:
1661:
Wallberg AE, Pedersen K, Lendahl U, Roeder RG (2002).
1548:
Nam Y, Sliz P, Song L, Aster JC, Blacklow SC (2006).
550:
1477:Alves-Guerra MC, Ronchini C, Capobianco AJ (2007).
1312:"Entrez Gene: MAML1 mastermind-like 1 (Drosophila)"
981:
960:
934:
913:
1156:
1154:
1152:
1135:
1133:
1131:
681:positive regulation of muscle cell differentiation
332:
231:
16:Protein-coding gene in the species Homo sapiens
1626:Nam Y, Weng AP, Aster JC, Blacklow SC (2003).
1211:
1209:
1161:GRCm38: Ensembl release 89: ENSMUSG00000050567
721:positive regulation of Notch signaling pathway
666:positive regulation of myotube differentiation
1841:
8:
1140:GRCh38: Ensembl release 89: ENSG00000161021
1848:
1834:
1826:
746:
676:regulation of transcription, DNA-templated
576:
373:
272:
169:
63:
1807:
1764:
1721:
1686:
1643:
1608:
1565:
1530:
1494:
1448:
1399:
1350:
1284:
1306:
1304:
630:intracellular membrane-bounded organelle
1863:
1127:
686:atrioventricular node cell development
18:
1591:Fryer CJ, White JB, Jones KA (2005).
337:
298:
293:
236:
195:
190:
7:
978:
957:
931:
910:
886:
867:
841:
822:
796:
777:
599:transcription coactivator activity
555:
473:
411:
390:
14:
1075:that in humans is encoded by the
671:atrioventricular node development
1866:
1800:10.1128/MCB.21.21.7403-7415.2001
1679:10.1128/MCB.22.22.7812-7819.2002
1441:10.1128/MCB.22.21.7688-7700.2002
1343:10.1128/MCB.22.22.7812-7819.2002
1277:10.1128/MCB.21.13.4337-4346.2001
321:
314:
308:
285:
220:
213:
207:
182:
27:
645:MAML1-RBP-Jkappa- ICN1 complex
539:More reference expression data
443:right hemisphere of cerebellum
1:
1496:10.1158/0008-5472.CAN-07-1720
306:
205:
1610:10.1016/j.molcel.2004.10.014
691:transcription, DNA-templated
1897:Genes on human chromosome 5
463:stromal cell of endometrium
1913:
1567:10.1016/j.cell.2005.12.037
1861:
1196:"Mouse PubMed Reference:"
1178:"Human PubMed Reference:"
1069:Mastermind-like protein 1
1055:
1050:
1046:
1039:
1023:
1010:Chr 5: 179.73 – 179.78 Mb
1004:
985:
964:
953:
938:
917:
906:
893:
889:
874:
870:
861:
848:
844:
829:
825:
816:
803:
799:
784:
780:
771:
756:
749:
745:
729:
579:
575:
563:
558:
549:
536:
485:
476:
423:
414:
384:
376:
372:
355:
342:
305:
284:
275:
271:
254:
241:
204:
181:
172:
168:
123:
120:
110:
103:
98:
71:
66:
49:
44:
39:
35:
26:
21:
1106:MAML1 has been shown to
1017:Chr 11: 50.15 – 50.18 Mb
701:myoblast differentiation
696:protein phosphorylation
661:Notch signaling pathway
594:peptide antigen binding
501:internal carotid artery
497:external carotid artery
1723:10.1074/jbc.M209529200
1645:10.1074/jbc.M301567200
1532:10.1074/jbc.M608974200
609:protein kinase binding
300:Chromosome 11 (mouse)
198:Chromosome 5 (human)
67:List of PDB id codes
40:Available structures
505:endocardial cushion
435:ganglionic eminence
1757:10.1101/gad.991602
1392:10.1101/gad.991602
851:ENSMUSG00000050567
654:Biological process
618:Cellular component
587:Molecular function
1884:
1883:
1066:
1065:
1062:
1061:
1035:
1034:
1000:
999:
975:
974:
949:
948:
928:
927:
902:
901:
883:
882:
857:
856:
838:
837:
812:
811:
793:
792:
741:
740:
571:
570:
567:
566:
545:
544:
532:
531:
470:
469:
451:left uterine tube
368:
367:
267:
266:
162:MAML1 - orthologs
94:
93:
90:
89:
50:Ortholog search:
1904:
1870:
1850:
1843:
1836:
1827:
1821:
1811:
1778:
1768:
1751:(11): 1397–411.
1735:
1725:
1716:(52): 50612–20.
1700:
1690:
1657:
1647:
1622:
1612:
1587:
1569:
1544:
1534:
1525:(16): 11969–81.
1508:
1498:
1463:
1462:
1452:
1435:(21): 7688–700.
1420:
1414:
1413:
1403:
1386:(11): 1397–411.
1371:
1365:
1364:
1354:
1322:
1316:
1315:
1308:
1299:
1298:
1288:
1256:
1250:
1249:
1213:
1204:
1203:
1192:
1186:
1185:
1174:
1168:
1158:
1147:
1137:
1048:
1047:
1019:
1012:
995:
979:
970:
958:
954:RefSeq (protein)
944:
932:
923:
911:
887:
868:
842:
823:
797:
778:
747:
577:
556:
541:
513:genital tubercle
481:
479:Top expressed in
474:
431:ventricular zone
419:
417:Top expressed in
412:
391:
374:
364:
351:
340:
325:
318:
312:
301:
289:
273:
263:
250:
239:
224:
217:
211:
200:
186:
170:
164:
115:
108:
85:
64:
58:
37:
36:
31:
19:
1912:
1911:
1907:
1906:
1905:
1903:
1902:
1901:
1887:
1886:
1885:
1880:
1877:
1871:
1857:
1854:
1824:
1794:(21): 7403–15.
1788:Mol. Cell. Biol
1781:
1738:
1703:
1667:Mol. Cell. Biol
1660:
1638:(23): 21232–9.
1625:
1590:
1547:
1511:
1476:
1472:
1470:Further reading
1467:
1466:
1429:Mol. Cell. Biol
1422:
1421:
1417:
1373:
1372:
1368:
1331:Mol. Cell. Biol
1324:
1323:
1319:
1310:
1309:
1302:
1271:(13): 4337–46.
1258:
1257:
1253:
1215:
1214:
1207:
1194:
1193:
1189:
1176:
1175:
1171:
1159:
1150:
1138:
1129:
1124:
1104:
1088:
1057:View/Edit Mouse
1052:View/Edit Human
1015:
1008:
1005:Location (UCSC)
991:
987:
966:
940:
919:
832:ENSG00000161021
725:
649:
613:
604:protein binding
537:
528:
523:
519:
515:
511:
507:
503:
499:
495:
491:
477:
466:
461:
457:
453:
449:
445:
441:
437:
433:
429:
415:
359:
346:
339:11|11 B1.3
338:
328:
327:
326:
319:
299:
276:Gene location (
258:
245:
237:
227:
226:
225:
218:
196:
173:Gene location (
124:
111:
104:
73:
51:
17:
12:
11:
5:
1910:
1908:
1900:
1899:
1889:
1888:
1882:
1881:
1879:
1878:
1872:
1865:
1862:
1859:
1858:
1855:
1853:
1852:
1845:
1838:
1830:
1823:
1822:
1779:
1736:
1701:
1673:(22): 7812–9.
1658:
1623:
1588:
1545:
1509:
1489:(18): 8690–8.
1473:
1471:
1468:
1465:
1464:
1415:
1366:
1337:(22): 7812–9.
1317:
1300:
1251:
1205:
1187:
1169:
1148:
1126:
1125:
1123:
1120:
1103:
1100:
1087:
1084:
1064:
1063:
1060:
1059:
1054:
1044:
1043:
1037:
1036:
1033:
1032:
1030:
1028:
1021:
1020:
1013:
1006:
1002:
1001:
998:
997:
983:
982:
976:
973:
972:
962:
961:
955:
951:
950:
947:
946:
936:
935:
929:
926:
925:
915:
914:
908:
904:
903:
900:
899:
891:
890:
884:
881:
880:
872:
871:
865:
859:
858:
855:
854:
846:
845:
839:
836:
835:
827:
826:
820:
814:
813:
810:
809:
801:
800:
794:
791:
790:
782:
781:
775:
769:
768:
763:
758:
754:
753:
743:
742:
739:
738:
727:
726:
724:
723:
718:
713:
708:
703:
698:
693:
688:
683:
678:
673:
668:
663:
657:
655:
651:
650:
648:
647:
642:
637:
632:
627:
621:
619:
615:
614:
612:
611:
606:
601:
596:
590:
588:
584:
583:
573:
572:
569:
568:
565:
564:
561:
560:
553:
547:
546:
543:
542:
534:
533:
530:
529:
527:
526:
522:
521:abdominal wall
518:
517:tail of embryo
514:
510:
506:
502:
498:
494:
490:
489:left lung lobe
486:
483:
482:
471:
468:
467:
465:
464:
460:
456:
452:
448:
447:gastric mucosa
444:
440:
436:
432:
428:
424:
421:
420:
408:
407:
399:
388:
382:
381:
378:RNA expression
370:
369:
366:
365:
357:
353:
352:
344:
341:
336:
330:
329:
320:
313:
307:
303:
302:
297:
291:
290:
282:
281:
269:
268:
265:
264:
256:
252:
251:
243:
240:
235:
229:
228:
219:
212:
206:
202:
201:
194:
188:
187:
179:
178:
166:
165:
122:
118:
117:
109:
101:
100:
96:
95:
92:
91:
88:
87:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1909:
1898:
1895:
1894:
1892:
1875:
1869:
1864:
1860:
1851:
1846:
1844:
1839:
1837:
1832:
1831:
1828:
1819:
1815:
1810:
1805:
1801:
1797:
1793:
1789:
1785:
1780:
1776:
1772:
1767:
1762:
1758:
1754:
1750:
1746:
1742:
1737:
1733:
1729:
1724:
1719:
1715:
1711:
1710:J. Biol. Chem
1707:
1702:
1698:
1694:
1689:
1684:
1680:
1676:
1672:
1668:
1664:
1659:
1655:
1651:
1646:
1641:
1637:
1633:
1632:J. Biol. Chem
1629:
1624:
1620:
1616:
1611:
1606:
1603:(4): 509–20.
1602:
1598:
1594:
1589:
1585:
1581:
1577:
1573:
1568:
1563:
1560:(5): 973–83.
1559:
1555:
1551:
1546:
1542:
1538:
1533:
1528:
1524:
1520:
1519:J. Biol. Chem
1516:
1510:
1506:
1502:
1497:
1492:
1488:
1484:
1480:
1475:
1474:
1469:
1460:
1456:
1451:
1446:
1442:
1438:
1434:
1430:
1426:
1419:
1416:
1411:
1407:
1402:
1397:
1393:
1389:
1385:
1381:
1377:
1370:
1367:
1362:
1358:
1353:
1348:
1344:
1340:
1336:
1332:
1328:
1321:
1318:
1313:
1307:
1305:
1301:
1296:
1292:
1287:
1282:
1278:
1274:
1270:
1266:
1265:Mol Cell Biol
1262:
1255:
1252:
1247:
1243:
1239:
1235:
1231:
1230:10.1038/82644
1227:
1223:
1219:
1212:
1210:
1206:
1201:
1197:
1191:
1188:
1183:
1179:
1173:
1170:
1166:
1162:
1157:
1155:
1153:
1149:
1145:
1141:
1136:
1134:
1132:
1128:
1121:
1119:
1117:
1113:
1109:
1101:
1099:
1097:
1092:
1085:
1083:
1081:
1078:
1074:
1070:
1058:
1053:
1049:
1045:
1042:
1038:
1031:
1029:
1026:
1022:
1018:
1014:
1011:
1007:
1003:
996:
994:
990:
984:
980:
977:
971:
969:
963:
959:
956:
952:
945:
943:
937:
933:
930:
924:
922:
916:
912:
909:
907:RefSeq (mRNA)
905:
898:
897:
892:
888:
885:
879:
878:
873:
869:
866:
864:
860:
853:
852:
847:
843:
840:
834:
833:
828:
824:
821:
819:
815:
808:
807:
802:
798:
795:
789:
788:
783:
779:
776:
774:
770:
767:
764:
762:
759:
755:
752:
748:
744:
737:
733:
728:
722:
719:
717:
714:
712:
709:
707:
704:
702:
699:
697:
694:
692:
689:
687:
684:
682:
679:
677:
674:
672:
669:
667:
664:
662:
659:
658:
656:
653:
652:
646:
643:
641:
638:
636:
633:
631:
628:
626:
625:nuclear speck
623:
622:
620:
617:
616:
610:
607:
605:
602:
600:
597:
595:
592:
591:
589:
586:
585:
582:
581:Gene ontology
578:
574:
562:
557:
554:
552:
548:
540:
535:
524:
520:
516:
512:
508:
504:
500:
496:
492:
488:
487:
484:
480:
475:
472:
462:
458:
454:
450:
446:
442:
438:
434:
430:
426:
425:
422:
418:
413:
410:
409:
406:
404:
400:
398:
397:
393:
392:
389:
387:
383:
379:
375:
371:
363:
358:
354:
350:
345:
335:
331:
324:
317:
311:
304:
296:
292:
288:
283:
279:
274:
270:
262:
257:
253:
249:
244:
234:
230:
223:
216:
210:
203:
199:
193:
189:
185:
180:
176:
171:
167:
163:
159:
155:
151:
147:
143:
139:
135:
131:
127:
119:
114:
107:
102:
97:
86:
84:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
1873:
1791:
1787:
1748:
1744:
1713:
1709:
1670:
1666:
1635:
1631:
1600:
1596:
1557:
1553:
1522:
1518:
1486:
1482:
1432:
1428:
1418:
1383:
1379:
1369:
1334:
1330:
1320:
1268:
1264:
1254:
1224:(4): 484–9.
1221:
1217:
1199:
1190:
1181:
1172:
1105:
1102:Interactions
1093:
1089:
1076:
1068:
1067:
993:NP_001388483
986:
965:
939:
918:
894:
875:
849:
830:
804:
785:
765:
760:
509:vas deferens
401:
394:
259:179,777,283
246:179,732,822
121:External IDs
72:
1856:PDB gallery
635:nucleoplasm
493:granulocyte
439:gallbladder
427:sural nerve
360:50,183,138
347:50,146,461
99:Identifiers
1483:Cancer Res
1167:, May 2017
1146:, May 2017
1122:References
459:left ovary
405:(ortholog)
142:HomoloGene
1745:Genes Dev
1597:Mol. Cell
1380:Genes Dev
1218:Nat Genet
989:NP_780543
968:NP_055572
942:NM_175334
921:NM_014757
751:Orthologs
150:GeneCards
1891:Category
1818:11585921
1775:12050117
1732:12386158
1697:12391150
1654:12644465
1619:15546612
1584:17809522
1576:16530044
1541:17317671
1505:17875709
1459:12370315
1410:12050117
1361:12391150
1295:11390662
1246:23335042
1238:11101851
1163:–
1142:–
1108:interact
1086:Function
1041:Wikidata
730:Sources:
1165:Ensembl
1144:Ensembl
1073:protein
863:UniProt
818:Ensembl
757:Species
736:QuickGO
640:nucleus
380:pattern
138:1890504
106:Aliases
1816:
1806:
1773:
1766:186317
1763:
1730:
1695:
1688:134732
1685:
1652:
1617:
1582:
1574:
1539:
1503:
1457:
1450:135662
1447:
1408:
1401:186317
1398:
1359:
1352:134732
1349:
1293:
1283:
1244:
1236:
1116:NOTCH1
1096:MamL-1
1027:search
1025:PubMed
896:Q6T264
877:Q92585
806:103806
773:Entrez
551:BioGPS
455:rectum
238:5q35.3
130:605424
1809:99913
1580:S2CID
1286:87094
1242:S2CID
1112:EP300
1110:with
1077:MAML1
1071:is a
766:Mouse
761:Human
732:Amigo
525:fossa
403:Mouse
396:Human
343:Start
278:Mouse
242:Start
175:Human
154:MAML1
113:MAML1
22:MAML1
1874:2f8x
1814:PMID
1771:PMID
1728:PMID
1693:PMID
1650:PMID
1615:PMID
1572:PMID
1554:Cell
1537:PMID
1501:PMID
1455:PMID
1406:PMID
1357:PMID
1291:PMID
1234:PMID
1114:and
1080:gene
787:9794
386:Bgee
334:Band
295:Chr.
233:Band
192:Chr.
146:8845
126:OMIM
83:3V79
79:3NBN
75:2F8X
56:RCSB
53:PDBe
1804:PMC
1796:doi
1761:PMC
1753:doi
1718:doi
1714:277
1683:PMC
1675:doi
1640:doi
1636:278
1605:doi
1562:doi
1558:124
1527:doi
1523:282
1491:doi
1445:PMC
1437:doi
1396:PMC
1388:doi
1347:PMC
1339:doi
1281:PMC
1273:doi
1226:doi
559:n/a
356:End
255:End
158:OMA
134:MGI
46:PDB
1893::
1812:.
1802:.
1792:21
1790:.
1786:.
1769:.
1759:.
1749:16
1747:.
1743:.
1726:.
1712:.
1708:.
1691:.
1681:.
1671:22
1669:.
1665:.
1648:.
1634:.
1630:.
1613:.
1601:16
1599:.
1595:.
1578:.
1570:.
1556:.
1552:.
1535:.
1521:.
1517:.
1499:.
1487:67
1485:.
1481:.
1453:.
1443:.
1433:22
1431:.
1427:.
1404:.
1394:.
1384:16
1382:.
1378:.
1355:.
1345:.
1335:22
1333:.
1329:.
1303:^
1289:.
1279:.
1269:21
1267:.
1263:.
1240:.
1232:.
1222:26
1220:.
1208:^
1198:.
1180:.
1151:^
1130:^
1118:.
1098:.
1082:.
734:/
362:bp
349:bp
261:bp
248:bp
156:;
152::
148:;
144::
140:;
136::
132:;
128::
81:,
77:,
1849:e
1842:t
1835:v
1820:.
1798::
1777:.
1755::
1734:.
1720::
1699:.
1677::
1656:.
1642::
1621:.
1607::
1586:.
1564::
1543:.
1529::
1507:.
1493::
1461:.
1439::
1412:.
1390::
1363:.
1341::
1314:.
1297:.
1275::
1248:.
1228::
1202:.
1184:.
280:)
177:)
160::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
