2182:
as the (adjacent) MAOB gene (Lenders et al., 1996). These patients did not exhibit any overt psychopathological alterations, pointing to a lack of overt clinical sequelae of MAOB deficiency (Lenders et al., 1996). ... The behavioral sequelae of MAO B deficiency are unlikely to be reflective of early neurodevelopmental problems (given the lower expression of this enzyme in perinatal stages), but may instead reflect tonic enhancements of PEA and/or other MAO B substrates. PEA is a trace amine that has been involved in several neuropsychiatric disorders (Beckmann et al., 1983; Szymanski et al., 1987; O'Reilly et al., 1991; Berry, 2007). The effects of PEA are not fully clear, but its chemical similarity with d-amphetamine (in which a methyl group is substituted at the α-carbon) underlines the possibility that this molecule may serve as a facilitator of catecholamine and serotonin release. On the other hand, the identification of TAAR1 as the endogenous receptor for PEA, as well as other monoamines metabolized by MAO B (such as tyramine and 3-iodothyronamine), calls into question whether the effects of PEA may result from a combination of different mechanisms.
2318:
bioavailability of tyramine is increased, which leads to an excess in NE, resulting in a hypertensive crisis (55, 217). Currently, they are not first-line antidepressant medications, and their use is limited to treatment-resistant or atypical depression. ... Selegiline is a selective MAO-B at low doses and a non-selective MAOI at higher doses; it also induces dopaminergic activity at low doses. This different action, depending on the dose, implies different use: low doses (up to 10 mg/day) for
Parkinson's disease and higher doses as antidepressant treatment (Table 1) (55). ... Higher doses of oral and transdermal selegiline have been linked to a major frequency of orthostatic hypotension (227). No hypertensive crisis was reported with patch administration, but a small portion of patients with preexisting hypertension showed a worse BP control (224).
2029:
also exists in catecholaminergic neurons, such as dopaminergic neurons in SN, norepinephrine neurons in locus coeruleus, etc. . MAO-B is mainly distributed in platelets and glial cells, and total MAO activity within the brain is composed of approximately 20% MAO-A and 80% MAO-B . Both MAO-A and MAO-B regulate the amine neurotransmitters, including dopamine. MAO-A metabolizes dopamine in presynaptic neurons, while MAO-B metabolizes dopamine released to synaptic cleft and taken up by glial cells. The number of glial cells was shown to increase with age, and in neurodegenerative diseases, as expected, the activity of MAO-B also increased . MAO-B inhibitors inhibit MAO-B activity in the brain, block dopamine catabolism, enhance dopamine signaling, and selectively enhance dopamine levels at synaptic cleft .
467:
444:
341:
366:
718:
473:
372:
1668:
1676:
1660:
42:
1505:, and dopamine (and other less clinically relevant chemicals). In contrast, MAO-B metabolizes dopamine and phenethylamine, as well as other less clinically relevant chemicals. The differences between the substrate selectivity of the two enzymes are utilized clinically when treating specific disorders; MAO-A
3112:
To the best of our knowledge, there have been no reports of clinical conditions characterized by selective MAO-B deficiency. However, in few cases of atypical ND with MAO-B deletion, the latter deficit was reported to result in increased urinary excretion of PEA, but no overt behavioral abnormalities
1517:
as a result of excessive norepinephrine. Likewise, the consumption of tyramine-containing substances, such as cheese, whilst using MAO-A inhibitors also carries the risk of hypertensive crisis. Selective MAO-B inhibitors bypass this problem by preferentially inhibiting MAO-B, which allows tyramine to
2181:
In striking contrast with the evidence on MAOA deficiency, the clinical consequences of low MAO B activity remain partially elusive. Indeed, the only cases with a documented loss-of-function mutation were described in atypical Norrie disease patients, harboring deletions of both the ND gene as well
2028:
There are two MAO isoenzymes: MAO-A and MAO-B. MAO-A is mainly distributed in the gastrointestinal tract, platelets, and heart, and can promote the metabolism of tyramine-containing substances in food so avoiding hypertensive crises caused by the accumulation of tyramine ("cheese reaction"). MAO-A
2317:
The risk of developing the "cheese reaction" during treatment with MAOIs depends on the concurrent consumption of meals containing tyramine or sympathomimetic drugs (Table 3). Tyramine is normally metabolized by MAO-A located on the gut wall and by MAO-B in the liver; if MAO-A is inhibited, the
3458:
Leonetti F, Capaldi C, Pisani L, Nicolotti O, Muncipinto G, Stefanachi A, Cellamare S, Caccia C, Carotti A (October 2007). "Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoamine oxidase".
68:
3776:
Chimenti F, Maccioni E, Secci D, Bolasco A, Chimenti P, Granese A, Befani O, Turini P, Alcaro S, Ortuso F, Cirilli R, La Torre F, Cardia MC, Distinto S (November 2005). "Synthesis, molecular modeling studies, and selective inhibitory activity against monoamine oxidase of
3531:
Carotti A, Catto M, Leonetti F, Campagna F, Soto-Otero R, Méndez-Alvarez E, Thull U, Testa B, Altomare C (November 2007). "Synthesis and monoamine oxidase inhibitory activity of new pyridazine-, pyrimidine- and 1,2,4-triazine-containing tricyclic derivatives".
3690:
Chimenti F, Maccioni E, Secci D, Bolasco A, Chimenti P, Granese A, Befani O, Turini P, Alcaro S, Ortuso F, Cardia MC, Distinto S (February 2007). "Selective inhibitory activity against MAO and molecular modeling studies of 2-thiazolylhydrazone derivatives".
3848:
Catto M, Nicolotti O, Leonetti F, Carotti A, Favia AD, Soto-Otero R, Méndez-Alvarez E, Carotti A (2006). "Structural insights into monoamine oxidase inhibitory potency and selectivity of 7-substituted coumarins from ligand- and target-based approaches".
3643:
Chimenti F, Secci D, Bolasco A, Chimenti P, Granese A, Carradori S, Yáñez M, Orallo F, Sanna ML, Gallinella B, Cirilli R (September 2010). "Synthesis, stereochemical separation, and biological evaluation of selective inhibitors of human MAO-B:
3495:
Frédérick R, Dumont W, Ooms F, Aschenbach L, Van der Schyf CJ, Castagnoli N, Wouters J, Krief A (June 2006). "Synthesis, structural reassignment, and biological activity of type B MAO inhibitors based on the 5H-indenopyridazin-5-one core".
2330:
Saura J, Luque JM, Cesura AM, Da Prada M, Chan-Palay V, Huber G, et al. (September 1994). "Increased monoamine oxidase B activity in plaque-associated astrocytes of
Alzheimer brains revealed by quantitative enzyme radioautography".
3735:
Chimenti F, Fioravanti R, Bolasco A, Manna F, Chimenti P, Secci D, Befani O, Turini P, Ortuso F, Alcaro S (February 2007). "Monoamine oxidase isoform-dependent tautomeric influence in the recognition of 3,5-diaryl pyrazole inhibitors".
3293:
Carotti A, Carrieri A, Chimichi S, Boccalini M, Cosimelli B, Gnerre C, Carotti A, Carrupt PA, Testa B (December 2002). "Natural and synthetic geiparvarins are strong and selective MAO-B inhibitors. Synthesis and SAR studies".
1345:. Depending on the substrate or bound inhibitor, it can exist in either an open or a closed form, which has been shown to be important in defining the inhibitor specificity of hMAO-B. At the end of the substrate cavity is the
4238:
Pretorius J, Malan SF, Castagnoli N, Bergh JJ, Petzer JP (September 2008). "Dual inhibition of monoamine oxidase B and antagonism of the adenosine A(2A) receptor by (E,E)-8-(4-phenylbutadien-1-yl)caffeine analogues".
3257:
Novaroli L, Daina A, Favre E, Bravo J, Carotti A, Leonetti F, Catto M, Carrupt PA, Reist M (October 2006). "Impact of species-dependent differences on screening, design, and development of MAO B inhibitors".
1627:
and behavioral abnormalities, people lacking the gene for MAO-B display no abnormalities except elevated phenethylamine levels in urine. Newer research indicates the importance of phenethylamine and other
3603:
Silvestri R, La Regina G, De
Martino G, Artico M, Befani O, Palumbo M, Agostinelli E, Turini P (March 2003). "Simple, potent, and selective pyrrole inhibitors of monoamine oxidase types A and B".
4274:
Tzvetkov NT, Hinz S, Küppers P, Gastreich M, Müller CE (August 2014). "Indazole- and indole-5-carboxamides: selective and reversible monoamine oxidase B inhibitors with subnanomolar potency".
4203:
Vlok N, Malan SF, Castagnoli N, Bergh JJ, Petzer JP (May 2006). "Inhibition of monoamine oxidase B by analogues of the adenosine A2A receptor antagonist (E)-8-(3-chlorostyryl)caffeine (CSC)".
1604:
Transgenic mice that are unable to produce MAO-B are shown to be resistant to a mouse model of
Parkinson's disease. They also demonstrate increased responsiveness to stress (as with MAO-A
1509:
have been typically used in the treatment of depression, whereas MAO-B inhibitors are typically used in the treatment of
Parkinson's disease. Concurrent use of MAO-A inhibitors with
3567:
Chimenti F, Fioravanti R, Bolasco A, Chimenti P, Secci D, Rossi F, Yáñez M, Orallo F, Ortuso F, Alcaro S (May 2009). "Chalcones: a valid scaffold for monoamine oxidases inhibitors".
2796:
Grimsby J, Toth M, Chen K, Kumazawa T, Klaidman L, Adams JD, Karoum F, Gal J, Shih JC (October 1997). "Increased stress response and beta-phenylethylamine in MAOB-deficient mice".
3955:
Matos MJ, Viña D, Picciau C, Orallo F, Santana L, Uriarte E (September 2009). "Synthesis and evaluation of 6-methyl-3-phenylcoumarins as potent and selective MAO-B inhibitors".
1294:
and plays an important role in the catabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. This protein preferentially degrades
3990:
Matos MJ, Viña D, Quezada E, Picciau C, Delogu G, Orallo F, Santana L, Uriarte E (June 2009). "A new series of 3-phenylcoumarins as potent and selective MAO-B inhibitors".
2423:
Nagatsu T, Sawada M (2006). "Molecular mechanism of the relation of monoamine oxidase B and its inhibitors to
Parkinson's disease: Possible implications of glial cells".
480:
379:
3812:
Mishra N, Sasmal D (April 2011). "Development of selective and reversible pyrazoline based MAO-B inhibitors: virtual screening, synthesis and biological evaluation".
1615:
Inhibition of MAO-B in rats has been shown to prevent many age-related biological changes such as optic nerve degeneration, and extend average lifespan by up to 39%.
3027:
Kitani K, Kanai S, Sato Y, Ohta M, Ivy GO, Carrillo MC (1993). "Chronic treatment of (-)deprenyl prolongs the life span of male
Fischer 344 rats. Further evidence".
1651:
The prophylactic use of MAO-B inhibitors to slow natural human aging in otherwise healthy individuals has been proposed, but remains a highly controversial topic.
1349:
cofactor with sites for favorable amine binding about the flavin involving two nearly parallel tyrosyl (398 and 435) residues that form what has been termed an
4026:
Gaspar A, Reis J, Fonseca A, Milhazes N, Viña D, Uriarte E, Borges F (January 2011). "Chromone 3-phenylcarboxamides as potent and selective MAO-B inhibitors".
3329:
Uebelhack R, Franke L, Schewe HJ (September 1998). "Inhibition of platelet MAO-B by kava pyrone-enriched extract from Piper methysticum
Forster (kava-kava)".
3920:
Matos MJ, Viña D, Janeiro P, Borges F, Santana L, Uriarte E (September 2010). "New halogenated 3-phenylcoumarins as potent and selective MAO-B inhibitors".
3885:
Matos MJ, Vazquez-Rodriguez S, Uriarte E, Santana L, Viña D (July 2011). "MAO inhibitory activity modulation: 3-Phenylcoumarins versus 3-benzoylcoumarins".
991:
302:
972:
3201:
Ukraintseva SV, Arbeev KG, Michalsky AI, Yashin AI (June 2004). "Antiaging treatments have been legally prescribed for approximately thirty years".
3423:
van
Diermen D, Marston A, Bravo J, Reist M, Carrupt PA, Hostettmann K (March 2009). "Monoamine oxidase inhibition by Rhodiola rosea L. roots".
2676:"Monoamine oxidase B is elevated in Alzheimer disease neurons, is associated with γ-secretase and regulates neuronal amyloid β-peptide levels"
1951:
3087:
2440:
4168:
Strydom B, Malan SF, Castagnoli N, Bergh JJ, Petzer JP (February 2010). "Inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues".
1933:
1318:
Monoamine oxidase B has a hydrophobic bipartite elongated cavity that (for the "open" conformation) occupies a combined volume close to 700
4314:
4062:
Manley-King CI, Bergh JJ, Petzer JP (January 2011). "Inhibition of monoamine oxidase by selected C5- and C6-substituted isatin analogues".
3127:"The emerging role of trace amine-associated receptor 1 in the functional regulation of monoamine transporters and dopaminergic activity"
1566:
466:
2097:"Structure-function relationships in flavoenzyme-dependent amine oxidations: A comparison of polyamine oxidase and monoamine oxidase"
1191:
1198:
443:
1969:
3374:"Evidences for the involvement of monoaminergic and GABAergic systems in antidepressant-like activity of garlic extract in mice"
2194:
Nolen WA, Hoencamp E, Bouvy PF, Haffmans PM (1993). "Reversible monoamine oxidase-A inhibitors in resistant major depression".
1920:
1899:
4098:
Manley-King CI, Bergh JJ, Petzer JP (August 2011). "Inhibition of monoamine oxidase by C5-substituted phthalimide analogues".
1916:
4133:
Strydom B, Bergh JJ, Petzer JP (August 2011). "8-Aryl- and alkyloxycaffeine analogues as inhibitors of monoamine oxidase".
2484:
Kumar MJ, Andersen JK (August 2004). "Perspectives on MAO-B in aging and neurological disease: where do we go from here?".
365:
340:
65:
1322:. hMAO-A has a single cavity that exhibits a rounder shape and is larger in volume than the "substrate cavity" of hMAO-B.
1895:
1280:
282:
1573:, responsible for the development of plaques, observed in Alzheimer's and Parkinson's patients. Evidence suggests that
1506:
1346:
1592:), slows the progression, improves and reverses the symptoms, associated with AD and PD, including the reduction of
479:
378:
1624:
472:
371:
2894:
Shih JC (January 2004). "Cloning, after cloning, knock-out mice, and physiological functions of MAO A and B.".
1036:
290:
1561:
and increased levels of MAO-B in the brain have also been linked to the accumulation of amyloid β-peptides (
1538:
1017:
1830:
1546:
1537:(PD) are both associated with elevated levels of MAO-B in the brain. The normal activity of MAO-B creates
1534:
1530:
1519:
2674:
Schedin-Weiss S, Inoue M, Hromadkova L, Teranishi Y, Yamamoto NG, Wiehager B, et al. (August 2017).
2529:"Negative emotionality: monoamine oxidase B gene variants modulate personality traits in healthy humans"
2143:"From aggression to autism: new perspectives on the behavioral sequelae of monoamine oxidase deficiency"
1574:
1284:
1541:, which directly damage cells. MAO-B levels have been found to increase with age, suggesting a role in
1444:
This reaction is believed to occur in three steps. First, the amine is oxidized to the corresponding
3210:
1510:
354:
2376:"Metabolic control analysis in a cellular model of elevated MAO-B: relevance to Parkinson's disease"
1990:"Monoamine Oxidase-B Inhibitors for the Treatment of Parkinson's Disease: Past, Present, and Future"
269:
2931:"Behavioral disinhibition and reduced anxiety-like behaviors in monoamine oxidase B-deficient mice"
1872:
1514:
1303:
2766:
Shih JC, Chen K (1999). "MAO-A and -B gene knock-out mice exhibit distinctly different behavior".
3354:
3234:
2821:
2627:"Monoamine oxidase B prompts mitochondrial and cardiac dysfunction in pressure overloaded hearts"
2509:
2458:
2356:
1702:
314:
1174:
1153:
1127:
1106:
2578:"Monoamine oxidases (MAO) in the pathogenesis of heart failure and ischemia/reperfusion injury"
2275:
Calvi A, Fischetti I, Verzicco I, Belvederi Murri M, Zanetidou S, Volpi R, et al. (2021).
4291:
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4043:
4007:
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3902:
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3794:
3753:
3716:
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3620:
3584:
3549:
3513:
3476:
3440:
3405:
3346:
3311:
3275:
3226:
3183:
3156:
3103:
3083:
3044:
3009:
2960:
2911:
2873:
2813:
2775:
2748:
2707:
2656:
2607:
2558:
2501:
2446:
2436:
2405:
2348:
2308:
2252:
2203:
2172:
2118:
2077:
2019:
1637:
1557:. Activity of MAO-B has also been shown to play a role in stress-induced cardiac damage. Over-
1554:
1372:
1272:
262:
58:
2727:"Monoamine oxidase inhibitors: promising therapeutic agents for Alzheimer's disease (Review)"
2625:
Kaludercic N, Carpi A, Nagayama T, Sivakumaran V, Zhu G, Lai EW, et al. (January 2014).
4283:
4248:
4212:
4177:
4142:
4107:
4071:
4035:
3999:
3964:
3929:
3894:
3858:
3821:
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3708:
3700:
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3653:
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3576:
3541:
3505:
3468:
3432:
3395:
3385:
3338:
3303:
3267:
3218:
3146:
3138:
3093:
3075:
3036:
2999:
2991:
2980:"Monoamine oxidase enzymes and oxidative stress in the rat optic nerve: age-related changes"
2950:
2942:
2903:
2863:
2855:
2805:
2738:
2697:
2687:
2646:
2638:
2597:
2589:
2548:
2540:
2493:
2428:
2395:
2387:
2340:
2298:
2288:
2242:
2234:
2162:
2154:
2108:
2067:
2059:
2009:
2001:
1581:
1545:
and the increased likelihood of developing neurological diseases later in life. More active
1542:
1367:, the initial step in the breakdown of these molecules. The products are the corresponding
559:
490:
434:
389:
2470:
1612:. In addition, they exhibit behavioral disinhibition and reduced anxiety-like behaviors.
1570:
1558:
717:
534:
310:
2048:"Structural insights into the mechanism of amine oxidation by monoamine oxidases A and B"
3214:
3064:"Behavioral outcomes of monoamine oxidase deficiency: preclinical and clinical evidence"
3400:
3373:
3151:
3126:
3098:
3079:
3063:
3004:
2979:
2955:
2930:
2868:
2843:
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2702:
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2602:
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2553:
2528:
2400:
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2142:
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2014:
1989:
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746:
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3238:
2825:
2513:
2374:
Mallajosyula JK, Chinta SJ, Rajagopalan S, Nicholls DG, Andersen JK (October 2009).
2360:
2859:
1683:
Species-dependent divergences may hamper the extrapolation of inhibitor potencies.
1679:
Structural formulae of high-affinity reversible MAO inhibitors selective for type B
1593:
1562:
1550:
552:
331:
294:
4146:
2593:
318:
2432:
1956:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1938:
National Center for Biotechnology Information, U.S. National Library of Medicine
1817:
1697:
1641:
1629:
1295:
4039:
4003:
3968:
3933:
3898:
3825:
1803:
Phenylcoumarins, extremely subtype selective and further analogs (see 3d model)
1675:
635:
4252:
4216:
4181:
4111:
4075:
3436:
2692:
2544:
2497:
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2158:
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1859:
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1585:
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451:
348:
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1727:
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1502:
936:
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573:
518:
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417:
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306:
4295:
4260:
4224:
4189:
4154:
4119:
4083:
4047:
4011:
3976:
3941:
3906:
3870:
3833:
3798:
3757:
3720:
3675:
3624:
3588:
3553:
3517:
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3444:
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3315:
3279:
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3107:
3013:
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2877:
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2505:
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1307:
1222:
1081:
1062:
3712:
3666:
1659:
2978:
Nebbioso M, Pascarella A, Cavallotti C, Pescosolido N (December 2012).
2809:
2005:
1376:
1048:
1003:
4287:
3862:
3790:
3749:
3704:
3657:
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87:
1812:
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1357:
1276:
1258:
1206:
958:
17:
3777:
1-thiocarbamoyl-3,5-diaryl-4,5-dihydro-(1H)- pyrazole derivatives".
2929:
Bortolato M, Godar SC, Davarian S, Chen K, Shih JC (December 2009).
2576:
Kaludercic N, Carpi A, Menabò R, Di Lisa F, Paolocci N (July 2011).
3113:
or cognitive deficits (Berger et al., 1992; Lenders et al., 1996).
1853:
1674:
1666:
1645:
1445:
1291:
921:
917:
1706:
1265:
286:
3644:
1-(4-arylthiazol-2-yl)-2-(3-methylcyclohexylidene)hydrazines".
726:
41:
2582:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
1778:
1-(4-Arylthiazol-2-yl)-2-(3-methylcyclohexylidene)hydrazine
542:
1271:
The protein encoded by this gene belongs to the flavin
1306:(MAO-A), MAO-B is also involved in the catabolism of
707:
1167:
1146:
1120:
1099:
1912:
1910:
1908:
1891:
1889:
1887:
897:positive regulation of dopamine metabolic process
489:
388:
2277:"Antidepressant Drugs Effects on Blood Pressure"
2141:Bortolato M, Floris G, Shih JC (November 2018).
2136:
2134:
2132:
2095:Binda C, Mattevi A, Edmondson DE (5 July 2002).
2046:Edmondson DE, Binda C, Mattevi A (August 2007).
1623:While people lacking the gene for MAO-A display
3252:
3250:
3248:
2984:International Journal of Experimental Pathology
2527:Dlugos AM, Palmer AA, de Wit H (October 2009).
1549:of the MAO-B gene have been linked to negative
1456:accepts two electrons and two protons from FADH
1325:The first cavity of hMAO-B has been termed the
27:Protein-coding gene in the species Homo sapiens
2791:
2789:
2041:
2039:
2037:
1917:GRCm38: Ensembl release 89: ENSMUSG00000040147
2889:
2887:
2270:
2268:
2266:
8:
1485:by water, forming ammonia and the aldehyde.
1448:, with reduction of the FAD cofactor to FADH
2844:"Monoamine oxidase: from genes to behavior"
1896:GRCh38: Ensembl release 89: ENSG00000069535
1829:)-8-(4-phenylbutadien-1-yl)caffeines, with
1553:, and suspected as an underlying factor in
1481:and regenerating FAD. Third, the imine is
1983:
1981:
1979:
1363:-dependent oxidation of primary arylalkyl
932:
862:negative regulation of serotonin secretion
742:
530:
429:
326:
76:
3665:
3399:
3389:
3150:
3097:
3003:
2954:
2867:
2742:
2701:
2691:
2650:
2601:
2552:
2399:
2302:
2292:
2246:
2166:
2112:
2071:
2013:
1658:
2223:"MAO-inhibitors in Parkinson's Disease"
1970:"Entrez Gene: MAOB monoamine oxidase B"
1883:
2466:
2456:
1754:-Indenopyridazin-5-ones (see 3d model)
1518:be metabolized freely by MAO-A in the
882:hydrogen peroxide biosynthetic process
31:
1543:natural age related cognitive decline
494:
455:
450:
393:
352:
347:
7:
4241:Bioorganic & Medicinal Chemistry
3068:International Review of Neurobiology
2425:Oxidative Stress and Neuroprotection
2281:Frontiers in Cardiovascular Medicine
1822:8-Benzyloxycaffeines and CSC analogs
1800:derivatives and #C19* (see 3d model)
1839:Indazole- and Indole-5-carboxamides
1584:of MAO-B through MAO-B inhibitors (
1567:amyloid precursor protein secretase
765:flavin adenine dinucleotide binding
3372:Dhingra D, Kumar V (August 2008).
3080:10.1016/B978-0-12-386467-3.00002-9
2680:Alzheimer's Research & Therapy
2631:Antioxidants & Redox Signaling
1988:Tan YY, Jenner P, Chen SD (2022).
1632:, which are now known to regulate
1164:
1143:
1117:
1096:
1072:
1053:
1027:
1008:
982:
963:
902:neurotransmitter catabolic process
712:
630:
568:
547:
25:
2221:Riederer P, Laux G (March 2011).
1489:Differences between MAOA and MAOB
1261:that in humans is encoded by the
760:protein homodimerization activity
3143:10.1111/j.1471-4159.2010.07109.x
2996:10.1111/j.1365-2613.2012.00832.x
2427:. Vol. 71. pp. 53–65.
716:
478:
471:
465:
442:
377:
370:
364:
339:
40:
2101:Journal of Biological Chemistry
1619:Effects of deficiency in humans
4276:Journal of Medicinal Chemistry
3851:Journal of Medicinal Chemistry
3534:Journal of Medicinal Chemistry
3461:Journal of Medicinal Chemistry
3378:Indian Journal of Pharmacology
3174:Miklya I (December 2009). "".
2860:10.1146/annurev.neuro.22.1.197
2533:Journal of Neural Transmission
2147:Journal of Neural Transmission
1994:Journal of Parkinson's Disease
867:response to lipopolysaccharide
796:integral component of membrane
780:primary amine oxidase activity
727:More reference expression data
696:More reference expression data
1:
3308:10.1016/S0960-894X(02)00798-9
3062:Bortolato M, Shih JC (2011).
2908:10.1016/s0161-813x(03)00112-8
2848:Annual Review of Neuroscience
1640:through the same receptor as
1565:), through mechanisms of the
646:epithelium of small intestine
463:
362:
4147:10.1016/j.ejmech.2011.05.014
3425:Journal of Ethnopharmacology
3041:10.1016/0024-3205(93)90219-S
2594:10.1016/j.bbamcr.2010.09.010
2345:10.1016/0306-4522(94)90311-5
1493:MAO-A generally metabolizes
1356:Like MAO-A, MAO-B catalyzes
1281:outer mitochondrial membrane
847:substantia nigra development
816:mitochondrial inner membrane
806:mitochondrial outer membrane
654:Epithelium of choroid plexus
4315:Genes on human chromosome X
2433:10.1007/978-3-211-33328-0_7
1341:199 side-chain serves as a
1337:(~390 Å) – between both an
892:response to toxic substance
857:response to steroid hormone
612:superior vestibular nucleus
4331:
4040:10.1016/j.bmcl.2010.11.128
4004:10.1016/j.bmcl.2009.04.085
3969:10.1016/j.bmcl.2009.07.039
3934:10.1016/j.bmcl.2010.07.013
3899:10.1016/j.bmcl.2011.05.074
3826:10.1016/j.bmcl.2011.02.030
3125:Miller GM (January 2011).
2842:, Chen K, Ridd MJ (1999).
2731:Molecular Medicine Reports
1526:Roles in disease and aging
877:dopamine catabolic process
852:response to corticosterone
770:electron transfer activity
4253:10.1016/j.bmc.2008.07.088
4217:10.1016/j.bmc.2006.01.011
4182:10.1016/j.bmc.2009.12.064
4112:10.1016/j.bmc.2011.06.070
4076:10.1016/j.bmc.2010.11.028
3437:10.1016/j.jep.2009.01.007
3176:Neuropsychopharmacol Hung
2693:10.1186/s13195-017-0279-1
2545:10.1007/s00702-009-0281-2
2392:10.1007/s12640-009-9032-2
2159:10.1007/s00702-018-1888-y
2064:10.1016/j.abb.2007.05.006
1952:"Mouse PubMed Reference:"
1934:"Human PubMed Reference:"
1625:intellectual disabilities
1237:
1232:
1228:
1221:
1205:
1186:
1171:
1150:
1139:
1124:
1103:
1092:
1079:
1075:
1060:
1056:
1047:
1034:
1030:
1015:
1011:
1002:
989:
985:
970:
966:
957:
942:
935:
931:
915:
745:
741:
724:
715:
706:
693:
642:
633:
580:
571:
541:
533:
529:
512:
499:
462:
441:
432:
428:
411:
398:
361:
338:
329:
325:
280:
277:
267:
260:
255:
84:
79:
62:
57:
52:
48:
39:
34:
2294:10.3389/fcvm.2021.704281
1709:extract; modest affinity
907:electron transport chain
872:response to aluminum ion
842:response to selenium ion
588:external globus pallidus
4028:Bioorg. Med. Chem. Lett
3992:Bioorg. Med. Chem. Lett
3957:Bioorg. Med. Chem. Lett
3922:Bioorg. Med. Chem. Lett
3887:Bioorg. Med. Chem. Lett
3814:Bioorg. Med. Chem. Lett
3391:10.4103/0253-7613.43165
3296:Bioorg. Med. Chem. Lett
3223:10.1196/annals.1297.014
2935:Neuropsychopharmacology
1844:Irreversible (covalent)
1539:reactive oxygen species
1199:Chr X: 16.58 – 16.68 Mb
1192:Chr X: 43.77 – 43.88 Mb
775:oxidoreductase activity
682:myocardium of ventricle
678:interventricular septum
658:upper respiratory tract
2486:Molecular Neurobiology
2380:Neurotoxicity Research
2239:10.5607/en.2011.20.1.1
2114:10.1074/jbc.R200005200
2052:Arch. Biochem. Biophys
1836:antagonistic component
1680:
1672:
1664:
1596:plaques in the brain.
1520:gastrointestinal tract
1314:Structure and Function
821:mitochondrial envelope
496:X A1.2|X 11.88 cM
3343:10.1055/s-2007-979325
2744:10.3892/mmr.2014.2040
2643:10.1089/ars.2012.4616
1809:-3-phenylcarboxamides
1771:-benzylaminomethyl)-1
1678:
1670:
1662:
1285:oxidative deamination
826:extracellular exosome
670:medial dorsal nucleus
273:, Monoamine oxidase B
3203:Ann. N. Y. Acad. Sci
2947:10.1038/npp.2009.118
1852:(Eldepryl, Zelapar,
1781:2-Thiazolylhydrazone
1655:Selective inhibitors
1329:(290 Å), the second
666:olfactory epithelium
600:middle frontal gyrus
457:X chromosome (mouse)
355:X chromosome (human)
80:List of PDB id codes
53:Available structures
3215:2004NYASA1019...64U
2498:10.1385/MN:30:1:077
2202:(Suppl 2): S69–76.
2196:Clin Neuropharmacol
2107:(27): 23973–23976.
1873:Monoamine oxidase A
1705:, a constituent of
1535:Parkinson's disease
1531:Alzheimer's disease
1515:hypertensive crisis
1513:drugs can induce a
1304:monoamine oxidase A
1283:. It catalyzes the
1251:Monoamine oxidase B
887:response to ethanol
674:islet of Langerhans
620:right lobe of liver
4024:compound #9, #12,
3331:Pharmacopsychiatry
2810:10.1038/ng1097-206
2725:Cai Z (May 2014).
2006:10.3233/JPD-212976
1703:Desmethoxyyangonin
1681:
1673:
1665:
1335:active site cavity
1037:ENSMUSG00000040147
835:Biological process
789:Cellular component
753:Molecular function
650:left lobe of liver
596:tail of epididymis
4288:10.1021/jm500729a
4282:(15): 6679–6703.
4205:Bioorg. Med. Chem
4170:Bioorg. Med. Chem
4100:Bioorg. Med. Chem
4064:Bioorg. Med. Chem
3863:10.1021/jm060183l
3791:10.1021/jm040903t
3750:10.1021/jm060868l
3705:10.1021/jm060869d
3658:10.1021/jm100120s
3617:10.1021/jm0256124
3581:10.1021/jm801590u
3546:10.1021/jm070728r
3510:10.1021/jm051091j
3473:10.1021/jm070725e
3272:10.1021/jm060441e
3089:978-0-12-386467-3
2768:Neurobiology (Bp)
2539:(10): 1323–1334.
2442:978-3-211-33327-3
2153:(11): 1589–1599.
1638:neurotransmission
1608:) and increased
1373:hydrogen peroxide
1275:family. It is an
1273:monoamine oxidase
1248:
1247:
1244:
1243:
1217:
1216:
1182:
1181:
1161:
1160:
1135:
1134:
1114:
1113:
1088:
1087:
1069:
1068:
1043:
1042:
1024:
1023:
998:
997:
979:
978:
927:
926:
737:
736:
733:
732:
702:
701:
689:
688:
627:
626:
525:
524:
424:
423:
251:
250:
247:
246:
63:Ortholog search:
16:(Redirected from
4322:
4300:
4299:
4271:
4265:
4264:
4235:
4229:
4228:
4200:
4194:
4193:
4165:
4159:
4158:
4130:
4124:
4123:
4094:
4088:
4087:
4058:
4052:
4051:
4022:
4016:
4015:
3987:
3981:
3980:
3952:
3946:
3945:
3917:
3911:
3910:
3881:
3875:
3874:
3844:
3838:
3837:
3809:
3803:
3802:
3768:
3762:
3761:
3731:
3725:
3724:
3686:
3680:
3679:
3669:
3635:
3629:
3628:
3599:
3593:
3592:
3564:
3558:
3557:
3528:
3522:
3521:
3491:
3485:
3484:
3455:
3449:
3448:
3420:
3414:
3413:
3403:
3393:
3369:
3363:
3362:
3326:
3320:
3319:
3290:
3284:
3283:
3254:
3243:
3242:
3198:
3192:
3191:
3178:(in Hungarian).
3171:
3165:
3164:
3154:
3122:
3116:
3115:
3101:
3059:
3053:
3052:
3024:
3018:
3017:
3007:
2975:
2969:
2968:
2958:
2926:
2920:
2919:
2891:
2882:
2881:
2871:
2836:
2830:
2829:
2793:
2784:
2783:
2763:
2757:
2756:
2746:
2722:
2716:
2715:
2705:
2695:
2671:
2665:
2664:
2654:
2622:
2616:
2615:
2605:
2588:(7): 1323–1332.
2573:
2567:
2566:
2556:
2524:
2518:
2517:
2481:
2475:
2474:
2468:
2464:
2462:
2454:
2420:
2414:
2413:
2403:
2371:
2365:
2364:
2327:
2321:
2320:
2306:
2296:
2272:
2261:
2260:
2250:
2218:
2212:
2211:
2191:
2185:
2184:
2170:
2138:
2127:
2126:
2116:
2092:
2086:
2085:
2075:
2043:
2032:
2031:
2017:
1985:
1974:
1973:
1966:
1960:
1959:
1948:
1942:
1941:
1930:
1924:
1914:
1903:
1893:
1480:
1479:
1478:
1470:
1469:
1440:
1439:
1438:
1428:
1427:
1426:
1418:
1417:
1407:
1405:
1404:
1394:
1393:
1392:
1331:substrate cavity
1287:of biogenic and
1253:, also known as
1230:
1229:
1201:
1194:
1177:
1165:
1156:
1144:
1140:RefSeq (protein)
1130:
1118:
1109:
1097:
1073:
1054:
1028:
1009:
983:
964:
933:
743:
729:
720:
713:
698:
662:nasal epithelium
638:
636:Top expressed in
631:
576:
574:Top expressed in
569:
548:
531:
521:
508:
497:
482:
475:
469:
458:
446:
430:
420:
407:
396:
381:
374:
368:
357:
343:
327:
321:
319:MAOB - orthologs
272:
265:
242:
77:
71:
50:
49:
44:
32:
21:
4330:
4329:
4325:
4324:
4323:
4321:
4320:
4319:
4305:
4304:
4303:
4273:
4272:
4268:
4247:(18): 8676–84.
4237:
4236:
4232:
4211:(10): 3512–21.
4202:
4201:
4197:
4167:
4166:
4162:
4132:
4131:
4127:
4106:(16): 4829–40.
4097:
4095:
4091:
4061:
4059:
4055:
4025:
4023:
4019:
3998:(12): 3268–70.
3989:
3988:
3984:
3954:
3953:
3949:
3928:(17): 5157–60.
3919:
3918:
3914:
3884:
3882:
3878:
3857:(16): 4912–25.
3847:
3845:
3841:
3811:
3810:
3806:
3785:(23): 7113–22.
3775:
3769:
3765:
3734:
3732:
3728:
3689:
3687:
3683:
3652:(17): 6516–20.
3642:
3636:
3632:
3602:
3600:
3596:
3566:
3565:
3561:
3540:(22): 5364–71.
3530:
3529:
3525:
3494:
3492:
3488:
3467:(20): 4909–16.
3457:
3456:
3452:
3422:
3421:
3417:
3371:
3370:
3366:
3328:
3327:
3323:
3292:
3291:
3287:
3266:(21): 6264–72.
3256:
3255:
3246:
3200:
3199:
3195:
3173:
3172:
3168:
3124:
3123:
3119:
3090:
3061:
3060:
3056:
3026:
3025:
3021:
2977:
2976:
2972:
2941:(13): 2746–57.
2928:
2927:
2923:
2896:Neurotoxicology
2893:
2892:
2885:
2838:
2837:
2833:
2798:Nature Genetics
2795:
2794:
2787:
2765:
2764:
2760:
2724:
2723:
2719:
2673:
2672:
2668:
2624:
2623:
2619:
2575:
2574:
2570:
2526:
2525:
2521:
2483:
2482:
2478:
2465:
2455:
2443:
2422:
2421:
2417:
2373:
2372:
2368:
2329:
2328:
2324:
2274:
2273:
2264:
2220:
2219:
2215:
2193:
2192:
2188:
2140:
2139:
2130:
2094:
2093:
2089:
2045:
2044:
2035:
1987:
1986:
1977:
1968:
1967:
1963:
1950:
1949:
1945:
1932:
1931:
1927:
1915:
1906:
1894:
1885:
1881:
1869:
1846:
1834:
1741:
1694:
1689:
1657:
1621:
1602:
1528:
1511:sympathomimetic
1491:
1477:
1474:
1473:
1472:
1468:
1465:
1464:
1463:
1461:
1459:
1455:
1451:
1437:
1434:
1433:
1432:
1430:
1425:
1422:
1421:
1420:
1416:
1413:
1412:
1411:
1409:
1403:
1400:
1399:
1398:
1396:
1391:
1388:
1387:
1386:
1384:
1361:
1327:entrance cavity
1316:
1279:located in the
1239:View/Edit Mouse
1234:View/Edit Human
1197:
1190:
1187:Location (UCSC)
1173:
1152:
1126:
1105:
1018:ENSG00000069535
911:
830:
784:
725:
694:
685:
680:
676:
672:
668:
664:
660:
656:
652:
648:
634:
623:
618:
614:
610:
606:
602:
598:
594:
590:
586:
572:
516:
503:
495:
485:
484:
483:
476:
456:
433:Gene location (
415:
402:
394:
384:
383:
382:
375:
353:
330:Gene location (
281:
268:
261:
86:
64:
28:
23:
22:
15:
12:
11:
5:
4328:
4326:
4318:
4317:
4307:
4306:
4302:
4301:
4266:
4230:
4195:
4176:(3): 1018–28.
4160:
4141:(8): 3474–85.
4135:Eur J Med Chem
4125:
4096:compound #5c,
4089:
4060:compound #9i,
4053:
4017:
3982:
3963:(17): 5053–5.
3947:
3912:
3893:(14): 4224–7.
3876:
3846:compound #41,
3839:
3820:(7): 1969–73.
3804:
3763:
3733:compound #3g,
3726:
3688:compound #18,
3681:
3630:
3601:compound #21,
3594:
3575:(9): 2818–24.
3559:
3523:
3504:(12): 3743–7.
3493:compound #2d,
3486:
3450:
3431:(2): 397–401.
3415:
3384:(4): 175–179.
3364:
3321:
3302:(24): 3551–5.
3285:
3244:
3193:
3166:
3137:(2): 164–176.
3117:
3088:
3054:
3019:
2970:
2921:
2902:(1–2): 21–30.
2883:
2831:
2785:
2758:
2737:(5): 1533–41.
2717:
2666:
2637:(2): 267–280.
2617:
2568:
2519:
2476:
2467:|journal=
2441:
2415:
2386:(3): 186–193.
2366:
2322:
2262:
2213:
2186:
2128:
2087:
2033:
2000:(2): 477–493.
1975:
1961:
1943:
1925:
1904:
1882:
1880:
1877:
1876:
1875:
1868:
1865:
1864:
1863:
1857:
1845:
1842:
1841:
1840:
1837:
1832:
1823:
1820:
1815:
1810:
1804:
1801:
1794:
1788:
1782:
1779:
1776:
1761:
1755:
1748:
1740:
1737:
1736:
1735:
1725:
1720:
1710:
1700:
1693:
1690:
1688:
1685:
1656:
1653:
1636:and serotonin
1620:
1617:
1601:
1598:
1527:
1524:
1499:norepinephrine
1490:
1487:
1475:
1466:
1457:
1453:
1449:
1442:
1441:
1435:
1423:
1414:
1401:
1389:
1359:
1315:
1312:
1302:. Similar to
1300:phenethylamine
1246:
1245:
1242:
1241:
1236:
1226:
1225:
1219:
1218:
1215:
1214:
1212:
1210:
1203:
1202:
1195:
1188:
1184:
1183:
1180:
1179:
1169:
1168:
1162:
1159:
1158:
1148:
1147:
1141:
1137:
1136:
1133:
1132:
1122:
1121:
1115:
1112:
1111:
1101:
1100:
1094:
1090:
1089:
1086:
1085:
1077:
1076:
1070:
1067:
1066:
1058:
1057:
1051:
1045:
1044:
1041:
1040:
1032:
1031:
1025:
1022:
1021:
1013:
1012:
1006:
1000:
999:
996:
995:
987:
986:
980:
977:
976:
968:
967:
961:
955:
954:
949:
944:
940:
939:
929:
928:
925:
924:
913:
912:
910:
909:
904:
899:
894:
889:
884:
879:
874:
869:
864:
859:
854:
849:
844:
838:
836:
832:
831:
829:
828:
823:
818:
813:
808:
803:
798:
792:
790:
786:
785:
783:
782:
777:
772:
767:
762:
756:
754:
750:
749:
739:
738:
735:
734:
731:
730:
722:
721:
710:
704:
703:
700:
699:
691:
690:
687:
686:
684:
683:
679:
675:
671:
667:
663:
659:
655:
651:
647:
643:
640:
639:
628:
625:
624:
622:
621:
617:
613:
609:
605:
601:
597:
593:
589:
585:
584:saphenous vein
581:
578:
577:
565:
564:
556:
545:
539:
538:
535:RNA expression
527:
526:
523:
522:
514:
510:
509:
501:
498:
493:
487:
486:
477:
470:
464:
460:
459:
454:
448:
447:
439:
438:
426:
425:
422:
421:
413:
409:
408:
400:
397:
392:
386:
385:
376:
369:
363:
359:
358:
351:
345:
344:
336:
335:
323:
322:
279:
275:
274:
266:
258:
257:
253:
252:
249:
248:
245:
244:
82:
81:
73:
72:
61:
55:
54:
46:
45:
37:
36:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
4327:
4316:
4313:
4312:
4310:
4297:
4293:
4289:
4285:
4281:
4277:
4270:
4267:
4262:
4258:
4254:
4250:
4246:
4242:
4234:
4231:
4226:
4222:
4218:
4214:
4210:
4206:
4199:
4196:
4191:
4187:
4183:
4179:
4175:
4171:
4164:
4161:
4156:
4152:
4148:
4144:
4140:
4136:
4129:
4126:
4121:
4117:
4113:
4109:
4105:
4101:
4093:
4090:
4085:
4081:
4077:
4073:
4070:(1): 261–74.
4069:
4065:
4057:
4054:
4049:
4045:
4041:
4037:
4033:
4029:
4021:
4018:
4013:
4009:
4005:
4001:
3997:
3993:
3986:
3983:
3978:
3974:
3970:
3966:
3962:
3958:
3951:
3948:
3943:
3939:
3935:
3931:
3927:
3923:
3916:
3913:
3908:
3904:
3900:
3896:
3892:
3888:
3883:compound #2,
3880:
3877:
3872:
3868:
3864:
3860:
3856:
3852:
3843:
3840:
3835:
3831:
3827:
3823:
3819:
3815:
3808:
3805:
3800:
3796:
3792:
3788:
3784:
3780:
3773:
3767:
3764:
3759:
3755:
3751:
3747:
3743:
3739:
3730:
3727:
3722:
3718:
3714:
3710:
3706:
3702:
3699:(4): 707–12.
3698:
3694:
3685:
3682:
3677:
3673:
3668:
3663:
3659:
3655:
3651:
3647:
3640:
3634:
3631:
3626:
3622:
3618:
3614:
3611:(6): 917–20.
3610:
3606:
3598:
3595:
3590:
3586:
3582:
3578:
3574:
3570:
3563:
3560:
3555:
3551:
3547:
3543:
3539:
3535:
3527:
3524:
3519:
3515:
3511:
3507:
3503:
3499:
3490:
3487:
3482:
3478:
3474:
3470:
3466:
3462:
3454:
3451:
3446:
3442:
3438:
3434:
3430:
3426:
3419:
3416:
3411:
3407:
3402:
3397:
3392:
3387:
3383:
3379:
3375:
3368:
3365:
3360:
3356:
3352:
3348:
3344:
3340:
3337:(5): 187–92.
3336:
3332:
3325:
3322:
3317:
3313:
3309:
3305:
3301:
3297:
3289:
3286:
3281:
3277:
3273:
3269:
3265:
3261:
3253:
3251:
3249:
3245:
3240:
3236:
3232:
3228:
3224:
3220:
3216:
3212:
3208:
3204:
3197:
3194:
3189:
3185:
3182:(4): 217–25.
3181:
3177:
3170:
3167:
3162:
3158:
3153:
3148:
3144:
3140:
3136:
3132:
3128:
3121:
3118:
3114:
3109:
3105:
3100:
3095:
3091:
3085:
3081:
3077:
3073:
3069:
3065:
3058:
3055:
3050:
3046:
3042:
3038:
3034:
3030:
3023:
3020:
3015:
3011:
3006:
3001:
2997:
2993:
2989:
2985:
2981:
2974:
2971:
2966:
2962:
2957:
2952:
2948:
2944:
2940:
2936:
2932:
2925:
2922:
2917:
2913:
2909:
2905:
2901:
2897:
2890:
2888:
2884:
2879:
2875:
2870:
2865:
2861:
2857:
2853:
2849:
2845:
2841:
2835:
2832:
2827:
2823:
2819:
2815:
2811:
2807:
2804:(2): 206–10.
2803:
2799:
2792:
2790:
2786:
2781:
2777:
2774:(2): 235–46.
2773:
2769:
2762:
2759:
2754:
2750:
2745:
2740:
2736:
2732:
2728:
2721:
2718:
2713:
2709:
2704:
2699:
2694:
2689:
2685:
2681:
2677:
2670:
2667:
2662:
2658:
2653:
2648:
2644:
2640:
2636:
2632:
2628:
2621:
2618:
2613:
2609:
2604:
2599:
2595:
2591:
2587:
2583:
2579:
2572:
2569:
2564:
2560:
2555:
2550:
2546:
2542:
2538:
2534:
2530:
2523:
2520:
2515:
2511:
2507:
2503:
2499:
2495:
2491:
2487:
2480:
2477:
2472:
2460:
2452:
2448:
2444:
2438:
2434:
2430:
2426:
2419:
2416:
2411:
2407:
2402:
2397:
2393:
2389:
2385:
2381:
2377:
2370:
2367:
2362:
2358:
2354:
2350:
2346:
2342:
2338:
2334:
2326:
2323:
2319:
2314:
2310:
2305:
2300:
2295:
2290:
2286:
2282:
2278:
2271:
2269:
2267:
2263:
2258:
2254:
2249:
2244:
2240:
2236:
2232:
2228:
2227:Exp Neurobiol
2224:
2217:
2214:
2209:
2205:
2201:
2197:
2190:
2187:
2183:
2178:
2174:
2169:
2164:
2160:
2156:
2152:
2148:
2144:
2137:
2135:
2133:
2129:
2124:
2120:
2115:
2110:
2106:
2102:
2098:
2091:
2088:
2083:
2079:
2074:
2069:
2065:
2061:
2058:(2): 269–76.
2057:
2053:
2049:
2042:
2040:
2038:
2034:
2030:
2025:
2021:
2016:
2011:
2007:
2003:
1999:
1995:
1991:
1984:
1982:
1980:
1976:
1971:
1965:
1962:
1957:
1953:
1947:
1944:
1939:
1935:
1929:
1926:
1922:
1918:
1913:
1911:
1909:
1905:
1901:
1897:
1892:
1890:
1888:
1884:
1878:
1874:
1871:
1870:
1866:
1861:
1858:
1855:
1851:
1848:
1847:
1843:
1838:
1835:
1828:
1824:
1821:
1819:
1816:
1814:
1811:
1808:
1805:
1802:
1799:
1795:
1792:
1789:
1787:
1783:
1780:
1777:
1774:
1770:
1766:
1762:
1760:
1756:
1753:
1749:
1746:
1743:
1742:
1738:
1733:
1729:
1726:
1724:
1721:
1718:
1714:
1711:
1708:
1704:
1701:
1699:
1696:
1695:
1691:
1686:
1684:
1677:
1669:
1661:
1654:
1652:
1649:
1647:
1643:
1639:
1635:
1634:catecholamine
1631:
1626:
1618:
1616:
1613:
1611:
1607:
1606:knockout mice
1600:Animal models
1599:
1597:
1595:
1591:
1587:
1583:
1580:of MAO-B, or
1579:
1576:
1572:
1568:
1564:
1560:
1556:
1552:
1548:
1547:polymorphisms
1544:
1540:
1536:
1532:
1525:
1523:
1521:
1516:
1512:
1508:
1504:
1500:
1496:
1488:
1486:
1484:
1447:
1408:→ Aldehyde +
1382:
1381:
1380:
1378:
1374:
1370:
1366:
1362:
1354:
1352:
1351:aromatic cage
1348:
1344:
1340:
1336:
1332:
1328:
1323:
1321:
1313:
1311:
1309:
1305:
1301:
1297:
1293:
1290:
1286:
1282:
1278:
1274:
1269:
1267:
1264:
1260:
1256:
1252:
1240:
1235:
1231:
1227:
1224:
1220:
1213:
1211:
1208:
1204:
1200:
1196:
1193:
1189:
1185:
1178:
1176:
1170:
1166:
1163:
1157:
1155:
1149:
1145:
1142:
1138:
1131:
1129:
1123:
1119:
1116:
1110:
1108:
1102:
1098:
1095:
1093:RefSeq (mRNA)
1091:
1084:
1083:
1078:
1074:
1071:
1065:
1064:
1059:
1055:
1052:
1050:
1046:
1039:
1038:
1033:
1029:
1026:
1020:
1019:
1014:
1010:
1007:
1005:
1001:
994:
993:
988:
984:
981:
975:
974:
969:
965:
962:
960:
956:
953:
950:
948:
945:
941:
938:
934:
930:
923:
919:
914:
908:
905:
903:
900:
898:
895:
893:
890:
888:
885:
883:
880:
878:
875:
873:
870:
868:
865:
863:
860:
858:
855:
853:
850:
848:
845:
843:
840:
839:
837:
834:
833:
827:
824:
822:
819:
817:
814:
812:
811:mitochondrion
809:
807:
804:
802:
799:
797:
794:
793:
791:
788:
787:
781:
778:
776:
773:
771:
768:
766:
763:
761:
758:
757:
755:
752:
751:
748:
747:Gene ontology
744:
740:
728:
723:
719:
714:
711:
709:
705:
697:
692:
681:
677:
673:
669:
665:
661:
657:
653:
649:
645:
644:
641:
637:
632:
629:
619:
615:
611:
607:
603:
599:
595:
591:
587:
583:
582:
579:
575:
570:
567:
566:
563:
561:
557:
555:
554:
550:
549:
546:
544:
540:
536:
532:
528:
520:
515:
511:
507:
502:
492:
488:
481:
474:
468:
461:
453:
449:
445:
440:
436:
431:
427:
419:
414:
410:
406:
401:
391:
387:
380:
373:
367:
360:
356:
350:
346:
342:
337:
333:
328:
324:
320:
316:
312:
308:
304:
300:
296:
292:
288:
284:
276:
271:
264:
259:
254:
243:
241:
237:
233:
229:
225:
221:
217:
213:
209:
205:
201:
197:
193:
189:
185:
181:
177:
173:
169:
165:
161:
157:
153:
149:
145:
141:
137:
133:
129:
125:
121:
117:
113:
109:
105:
101:
97:
93:
89:
83:
78:
75:
74:
70:
67:
60:
56:
51:
47:
43:
38:
33:
30:
19:
4279:
4275:
4269:
4244:
4240:
4233:
4208:
4204:
4198:
4173:
4169:
4163:
4138:
4134:
4128:
4103:
4099:
4092:
4067:
4063:
4056:
4034:(2): 707–9.
4031:
4027:
4020:
3995:
3991:
3985:
3960:
3956:
3950:
3925:
3921:
3915:
3890:
3886:
3879:
3854:
3850:
3842:
3817:
3813:
3807:
3782:
3779:J. Med. Chem
3778:
3771:
3766:
3744:(3): 425–8.
3741:
3738:J. Med. Chem
3737:
3729:
3713:11573/231039
3696:
3693:J. Med. Chem
3692:
3684:
3667:11573/360702
3649:
3646:J. Med. Chem
3645:
3638:
3637:compound # (
3633:
3608:
3605:J. Med. Chem
3604:
3597:
3572:
3569:J. Med. Chem
3568:
3562:
3537:
3533:
3526:
3501:
3498:J. Med. Chem
3497:
3489:
3464:
3460:
3453:
3428:
3424:
3418:
3381:
3377:
3367:
3334:
3330:
3324:
3299:
3295:
3288:
3263:
3260:J. Med. Chem
3259:
3206:
3202:
3196:
3179:
3175:
3169:
3134:
3131:J. Neurochem
3130:
3120:
3111:
3071:
3067:
3057:
3035:(3): 281–8.
3032:
3028:
3022:
2990:(6): 401–5.
2987:
2983:
2973:
2938:
2934:
2924:
2899:
2895:
2851:
2847:
2834:
2801:
2797:
2771:
2767:
2761:
2734:
2730:
2720:
2683:
2679:
2669:
2634:
2630:
2620:
2585:
2581:
2571:
2536:
2532:
2522:
2492:(1): 77–89.
2489:
2485:
2479:
2424:
2418:
2383:
2379:
2369:
2339:(1): 15–30.
2336:
2333:Neuroscience
2332:
2325:
2316:
2284:
2280:
2230:
2226:
2216:
2199:
2195:
2189:
2180:
2150:
2146:
2104:
2100:
2090:
2055:
2051:
2027:
1997:
1993:
1964:
1955:
1946:
1937:
1928:
1826:
1818:Phthalimides
1772:
1768:
1764:
1757:Substituted
1751:
1731:
1682:
1671:(+)-Catechin
1650:
1630:trace amines
1622:
1614:
1603:
1551:emotionality
1529:
1492:
1452:. Second, O
1443:
1355:
1350:
1342:
1334:
1330:
1326:
1324:
1317:
1270:
1262:
1254:
1250:
1249:
1172:
1151:
1125:
1104:
1080:
1061:
1035:
1016:
990:
971:
951:
946:
604:hypothalamus
558:
551:
278:External IDs
85:
29:
3770:compound #(
3209:(1): 64–9.
2854:: 197–217.
2233:(1): 1–17.
1793:derivatives
1784:3,5-Diaryl
1747:and analogs
1717:epicatechin
1698:Geiparvarin
1663:Geiparvarin
1642:amphetamine
1571:γ-secretase
1296:benzylamine
517:16,683,605
504:16,575,521
416:43,882,450
403:43,766,610
256:Identifiers
2287:: 704281.
1923:, May 2017
1902:, May 2017
1879:References
1860:Rasagiline
1850:Selegiline
1791:Pyrazoline
1745:Safinamide
1687:Reversible
1590:Rasagiline
1582:inhibition
1559:expression
1555:depression
1507:inhibitors
1483:hydrolyzed
1460:, forming
1339:isoleucine
1289:xenobiotic
608:left ovary
562:(ortholog)
299:HomoloGene
3074:: 13–42.
2686:(1): 57.
2469:ignored (
2459:cite book
1862:(Azilect)
1759:chalcones
1739:Synthetic
1728:Rosiridin
1586:Selegline
1578:silencing
1533:(AD) and
1503:serotonin
1175:NP_766366
1154:NP_000889
1128:NM_172778
1107:NM_000898
937:Orthologs
307:GeneCards
4309:Category
4296:24955776
4261:18723354
4225:16442801
4190:20093036
4155:21621312
4120:21778064
4084:21134756
4048:21194943
4012:19423346
3977:19628387
3942:20659799
3907:21684743
3871:16884303
3834:21377879
3799:16279769
3758:17266193
3721:17253676
3676:20715818
3625:12620068
3589:19378991
3554:17910428
3518:16759116
3481:17824599
3445:19168123
3410:20040952
3359:25270815
3316:12443774
3280:17034132
3239:25181147
3231:15246996
3188:20150659
3161:21073468
3108:21971001
3029:Life Sci
3014:23082958
2965:19710633
2916:14697877
2878:10202537
2826:31804364
2780:10591056
2753:24626484
2712:28764767
2661:23581564
2612:20869994
2563:19657584
2514:19776473
2506:15247489
2451:17447416
2410:19526285
2361:38740469
2313:34414219
2257:22110357
2177:29748850
2123:12015330
2082:17573034
2024:34957948
1919:–
1898:–
1867:See also
1807:Chromone
1798:coumarin
1796:Several
1786:pyrazole
1775:-pyrrole
1767:-Methyl-
1732:in vitro
1713:Catechin
1495:tyramine
1383:Amine +
1369:aldehyde
1308:dopamine
1257:, is an
1223:Wikidata
916:Sources:
801:membrane
3401:2792615
3351:9832350
3211:Bibcode
3152:3005101
3099:3371272
3049:8423709
3005:3521895
2956:2783894
2869:2844879
2840:Shih JC
2818:9326944
2703:5540560
2652:3887464
2603:3030628
2554:3653168
2401:2727365
2353:7816197
2304:8370473
2248:3213739
2208:8313400
2168:6215718
2073:1993809
2015:8925102
1921:Ensembl
1900:Ensembl
1813:Isatins
1692:Natural
1377:ammonia
1049:UniProt
1004:Ensembl
943:Species
922:QuickGO
592:decidua
537:pattern
263:Aliases
4294:
4259:
4223:
4188:
4153:
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