316:
293:
190:
215:
35:
322:
221:
4407:
61:
2270:
2555:
1517:
Nishina H, Vaz C, Billia P, Nghiem M, Sasaki T, De la Pompa JL, et al. (February 1999). "Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4".
1436:
Lin A, Minden A, Martinetto H, Claret FX, Lange-Carter C, Mercurio F, et al. (April 1995). "Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2".
2263:
1613:"Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes"
1778:"Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells"
2256:
329:
228:
2463:
1727:"JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension"
3011:
3850:
2314:
3959:
4432:
2697:
2584:
901:
151:
2972:
882:
3945:
3410:
2301:
2283:
1276:
knockout mice revealed embryonic lethality, impaired hepatogenesis and defective liver formation. Analysis of chimeric mice identified a role for
1233:
4047:
3928:
20:
2120:"Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade"
3634:
2503:
4427:
3698:
2673:
2022:"Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation"
1418:
1400:
3954:
315:
2488:
4011:
3686:
2238:
1149:
2071:"JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway"
1156:
292:
4126:
2943:
2933:
2618:
3625:
1252:/p38 are substrates for MAP2K4, but MAPK1/ERK2 and MAPK3/ERK1 are not phosphorylated by MAP2K4. Structurally, MAP2K4 contains a
3894:
3566:
2928:
2919:
1387:
1366:
214:
189:
4282:
1383:
58:
3309:
2806:
2797:
2454:
2400:
4397:
1362:
2497:
131:
122:, JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1, mitogen-activated protein kinase kinase 4
1662:"SEK1/MKK4 is required for maintenance of a normal peripheral lymphoid compartment but not for lymphocyte development"
1554:"SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis"
1297:
328:
227:
2248:
1611:
Nishina H, Bachmann M, Oliveira-dos-Santos AJ, Kozieradzki I, Fischer KD, Odermatt B, et al. (September 1997).
3521:
3339:
2835:
321:
220:
4267:
4383:
4370:
4357:
4344:
4331:
4318:
4305:
3511:
3506:
3501:
3491:
3486:
3481:
3471:
3266:
3041:
2637:
4277:
1493:
4231:
4174:
3734:
3725:
3676:
2442:
2287:
946:
139:
4179:
4034:
3457:
1229:
927:
4200:
4119:
2733:
203:
4272:
3300:
1974:
1830:
1565:
1445:
118:
4236:
1132:
1122:
1114:
1110:
1106:
1087:
1061:
1051:
1047:
1043:
1039:
1016:
3808:
2171:"MKK4/SEK1 is negatively regulated through a feedback loop involving the E3 ubiquitin ligase itch"
4437:
4169:
3911:
3865:
1819:"JLP: A scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors"
163:
2069:
Ito M, Yoshioka K, Akechi M, Yamashita S, Takamatsu N, Sugiyama K, et al. (November 1999).
1118:
1091:
1035:
1020:
3171:
2880:
2234:
2202:
2151:
2100:
2051:
2002:
1943:
1902:
1858:
1799:
1758:
1683:
1642:
1593:
1534:
1461:
111:
51:
2118:
Matsuura H, Nishitoh H, Takeda K, Matsuzawa A, Amagasa T, Ito M, et al. (October 2002).
4215:
4210:
4184:
4112:
3764:
3006:
2996:
2991:
2909:
2900:
2830:
2821:
2767:
2758:
2415:
2192:
2182:
2141:
2131:
2090:
2082:
2041:
2033:
1992:
1982:
1963:"Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase"
1933:
1892:
1848:
1838:
1789:
1748:
1738:
1673:
1632:
1624:
1583:
1573:
1526:
1453:
408:
339:
283:
238:
159:
4262:
4246:
4159:
3590:
2661:
2656:
2651:
1479:
1285:
383:
1922:"Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2"
1776:
Marti A, Luo Z, Cunningham C, Ohta Y, Hartwig J, Stossel TP, et al. (January 1997).
1978:
1834:
1569:
1449:
34:
4411:
4300:
4241:
2197:
2170:
1660:
Swat W, Fujikawa K, Ganiatsas S, Yang D, Xavier RJ, Harris NL, et al. (May 1998).
1637:
1612:
1265:
1881:"Akt (protein kinase B) negatively regulates SEK1 by means of protein phosphorylation"
1853:
1818:
1753:
1726:
1701:
1678:
1661:
816:
811:
806:
801:
796:
791:
786:
781:
776:
771:
766:
761:
756:
751:
746:
741:
736:
731:
726:
721:
716:
711:
706:
690:
685:
680:
675:
670:
665:
649:
644:
639:
634:
629:
624:
619:
614:
609:
604:
599:
4421:
4205:
4164:
2714:
2646:
2095:
2070:
2046:
2021:
1997:
1962:
1588:
1553:
1269:
586:
2037:
143:
4154:
3585:
2410:
1552:
Ganiatsas S, Kwee L, Fujiwara Y, Perkins A, Ikeda T, Labow MA, Zon LI (June 1998).
401:
180:
2225:
Lin, A (2006). "The JNK Signaling
Pathway (Molecular Biology Intelligence Unit)".
167:
4378:
4313:
4149:
3791:
3423:
3363:
3246:
3166:
2890:
1423:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1405:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1310:
1237:
4406:
1967:
Proceedings of the
National Academy of Sciences of the United States of America
1823:
Proceedings of the
National Academy of Sciences of the United States of America
1558:
Proceedings of the
National Academy of Sciences of the United States of America
484:
3879:
2353:
1261:
300:
197:
147:
4352:
4326:
2840:
2187:
1987:
1578:
1457:
846:
544:
422:
367:
354:
266:
253:
155:
2206:
2155:
2136:
2119:
2104:
2086:
2055:
1947:
1938:
1921:
1906:
1897:
1880:
1879:
Park HS, Kim MS, Huh SH, Park J, Chung J, Kang SS, Choi EJ (January 2002).
1862:
1843:
1794:
1777:
1743:
2006:
1803:
1762:
1687:
1646:
1628:
1597:
1538:
1530:
1465:
1196:
1191:
3196:
3091:
3086:
3081:
1322:
1180:
991:
972:
3855:
3833:
3828:
3818:
3813:
3615:
3610:
3605:
3600:
3595:
3580:
3575:
3226:
3191:
2430:
2425:
2420:
1961:
Tournier C, Whitmarsh AJ, Cavanagh J, Barrett T, Davis RJ (July 1997).
958:
913:
1817:
Lee CM, Onésime D, Reddy CD, Dhanasekaran N, Reddy EP (October 2002).
88:
84:
80:
4365:
4135:
4085:
4080:
4075:
4065:
4060:
4055:
4006:
4001:
3996:
3991:
3986:
3969:
3964:
3838:
3823:
3774:
3769:
3754:
3749:
3744:
3739:
3713:
3708:
3703:
3691:
3669:
3664:
3556:
3531:
3206:
3031:
3026:
3021:
3016:
3001:
2845:
2782:
2777:
2772:
2748:
2574:
2569:
2543:
2538:
2533:
2523:
2518:
2508:
2348:
2279:
2146:
1304:
1257:
1253:
1249:
1212:
1164:
868:
1240:
in response to various environmental stresses or mitogenic stimuli.
4339:
3981:
3974:
3884:
3781:
3681:
3659:
3654:
3649:
3644:
3639:
3551:
3546:
3541:
3536:
3526:
3496:
3476:
3353:
3348:
3329:
3324:
3314:
3290:
3285:
3280:
3256:
3251:
3241:
3236:
3231:
3221:
3201:
3186:
3181:
3176:
3156:
3151:
3141:
3136:
3131:
3126:
3121:
3111:
3106:
3101:
3096:
3076:
3071:
3066:
3061:
3056:
3051:
3036:
2986:
2981:
2875:
2870:
2865:
2860:
2855:
2850:
2811:
2743:
2738:
2687:
2682:
2608:
2603:
2598:
2564:
2556:
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase
2358:
2343:
2338:
2333:
2328:
2323:
1316:
1245:
1241:
831:
827:
792:
positive regulation of nitric-oxide synthase biosynthetic process
3874:
3801:
3796:
3786:
3759:
3516:
3466:
3447:
3442:
3437:
3432:
3387:
3382:
3377:
3372:
3319:
3275:
3216:
3211:
3161:
3146:
3116:
3046:
2962:
2957:
2952:
2885:
2787:
2728:
2723:
2627:
2593:
2478:
2473:
2468:
2437:
2405:
2393:
2388:
2383:
2373:
2368:
1334:
1328:
1219:
135:
4108:
4032:
3408:
2299:
2252:
3843:
2378:
2363:
762:
positive regulation of smooth muscle cell apoptotic process
4104:
1209:
Dual-specificity mitogen-activated protein kinase kinase 4
391:
752:
cell growth involved in cardiac muscle cell development
1725:
Xia Y, Wu Z, Su B, Murray B, Karin M (November 1998).
650:
mitogen-activated protein kinase kinase kinase binding
4395:
742:
negative regulation of motor neuron apoptotic process
556:
2020:
Cheng J, Yang J, Xia Y, Karin M, Su B (April 2000).
1288:. MAP2K4 is altered in 1.97% of all human cancers.
4291:
4255:
4224:
4193:
4142:
4046:
3944:
3927:
3910:
3893:
3864:
3724:
3624:
3565:
3456:
3422:
3362:
3338:
3299:
3265:
2971:
2942:
2918:
2899:
2820:
2796:
2757:
2713:
2696:
2672:
2636:
2617:
2583:
2554:
2487:
2453:
2313:
1105:
1080:
1034:
1009:
495:
dentate gyrus of hippocampal formation granule cell
1379:
1377:
1375:
1358:
1356:
1354:
1280:in T cell cytokine production and proliferation.
802:stress-activated protein kinase signaling cascade
338:
237:
1874:
1872:
1256:domain that is phosphorylated and activated by
777:positive regulation of neuron apoptotic process
16:Protein-coding gene in the species Homo sapiens
1384:GRCm38: Ensembl release 89: ENSMUSG00000033352
772:positive regulation of protein phosphorylation
4120:
2315:Non-specific serine/threonine protein kinases
2264:
8:
1284:-deficient chimeric mice frequently develop
1363:GRCh38: Ensembl release 89: ENSG00000065559
4127:
4113:
4105:
4043:
4029:
3419:
3405:
2698:Goodpasture-antigen-binding protein kinase
2310:
2296:
2271:
2257:
2249:
1102:
1031:
842:
582:
379:
278:
175:
69:
3411:Serine/threonine-specific protein kinases
2585:(isocitrate dehydrogenase (NADP+)) kinase
2302:Serine/threonine-specific protein kinases
2284:Serine/threonine-specific protein kinases
2196:
2186:
2145:
2135:
2094:
2045:
1996:
1986:
1937:
1896:
1852:
1842:
1793:
1752:
1742:
1677:
1636:
1587:
1577:
3946:Receptor protein serine/threonine kinase
787:positive regulation of apoptotic process
722:cellular response to mechanical stimulus
645:protein serine/threonine kinase activity
4402:
3929:Low-density-lipoprotein receptor kinase
1350:
1260:(aka MEKK1). MAP2K4 contains multiple
531:paraventricular nucleus of hypothalamus
21:Mitogen-activated protein kinase kinase
1480:"P45985 | SWISS-MODEL Repository"
782:positive regulation of DNA replication
24:
2674:Fas-activated serine/threonine kinase
817:Fc-epsilon receptor signaling pathway
807:activation of protein kinase activity
343:
304:
299:
242:
201:
196:
7:
3955:Bone morphogenetic protein receptors
1617:The Journal of Experimental Medicine
2489:Dephospho-(reductase kinase) kinase
2175:The Journal of Biological Chemistry
2124:The Journal of Biological Chemistry
1926:The Journal of Biological Chemistry
1885:The Journal of Biological Chemistry
1782:The Journal of Biological Chemistry
2944:G-protein coupled receptor kinases
1077:
1006:
982:
963:
937:
918:
892:
873:
561:
479:
417:
396:
14:
4433:Mitogen-activated protein kinases
2934:Beta adrenergic receptor kinase-2
2619:(tyrosine 3-monooxygenase) kinase
2169:Ahn YH, Kurie JM (October 2009).
1215:that in humans is encoded by the
732:peptidyl-tyrosine phosphorylation
433:lateral nuclear group of thalamus
4405:
3626:Mitogen-activated protein kinase
797:regulation of mitotic cell cycle
625:protein tyrosine kinase activity
523:dorsomedial hypothalamic nucleus
327:
320:
314:
291:
226:
219:
213:
188:
33:
4012:Anti-Müllerian hormone receptor
3895:(acetyl-CoA carboxylase) kinase
3567:(RNA-polymerase)-subunit kinase
2929:Beta adrenergic receptor kinase
2920:Beta adrenergic receptor kinase
2038:10.1128/MCB.20.7.2334-2342.2000
812:regulation of apoptotic process
3635:Extracellular signal-regulated
2075:Molecular and Cellular Biology
2026:Molecular and Cellular Biology
545:More reference expression data
1:
3699:P38 mitogen-activated protein
2798:cGMP-dependent protein kinase
2759:cAMP-dependent protein kinase
2455:Pyruvate dehydrogenase kinase
2401:Ataxia telangiectasia mutated
1679:10.1016/s1074-7613(00)80567-1
1234:Ser/Thr protein kinase family
757:cellular response to sorbitol
312:
211:
4428:Genes on human chromosome 17
2498:AMP-activated protein kinase
1920:Chen Z, Cobb MH (May 2001).
515:anterior horn of spinal cord
3413:(EC 2.7.11.21-EC 2.7.11.30)
1702:"MAP2K4 - My Cancer Genome"
4454:
3340:Elongation factor 2 kinase
2304:(EC 2.7.11.1-EC 2.7.11.20)
640:JUN kinase kinase activity
635:MAP kinase kinase activity
18:
4283:Michaelis–Menten kinetics
4042:
4028:
3735:MAP kinase kinase kinases
3418:
3404:
3267:Myosin light-chain kinase
2973:Ca2+/calmodulin-dependent
2638:Myosin-heavy-chain kinase
2309:
2295:
1419:"Mouse PubMed Reference:"
1401:"Human PubMed Reference:"
1296:MAP2K4 has been shown to
1195:
1190:
1186:
1179:
1163:
1144:
1129:
1084:
1073:
1058:
1013:
1002:
989:
985:
970:
966:
957:
944:
940:
925:
921:
912:
899:
895:
880:
876:
867:
852:
845:
841:
825:
585:
581:
569:
564:
555:
542:
491:
482:
429:
420:
390:
382:
378:
361:
348:
311:
290:
281:
277:
260:
247:
210:
187:
178:
174:
129:
126:
116:
109:
104:
77:
72:
55:
50:
45:
41:
32:
27:
4175:Diffusion-limited enzyme
4035:Dual-specificity kinases
1272:. Genetic studies using
1236:. MAP2K4 phosphorylates
1157:Chr 11: 65.58 – 65.68 Mb
1150:Chr 17: 12.02 – 12.14 Mb
3458:Cyclin-dependent kinase
2188:10.1074/jbc.M109.044958
1988:10.1073/pnas.94.14.7337
1731:Genes & Development
1579:10.1073/pnas.95.12.6881
1458:10.1126/science.7716521
1230:dual-specificity kinase
717:protein phosphorylation
605:protein kinase activity
2137:10.1074/jbc.M202004200
2087:10.1128/mcb.19.11.7539
1939:10.1074/jbc.M100681200
1898:10.1074/jbc.M110299200
1844:10.1073/pnas.232310199
1795:10.1074/jbc.272.5.2620
1744:10.1101/gad.12.21.3369
1706:www.mycancergenome.org
507:superior frontal gyrus
457:superior frontal gyrus
345:11 B3|11 40.53 cM
4268:Eadie–Hofstee diagram
4201:Allosteric regulation
1629:10.1084/jem.186.6.941
1531:10.1242/dev.126.3.505
511:primary visual cortex
453:middle temporal gyrus
306:Chromosome 11 (mouse)
204:Chromosome 17 (human)
4278:Lineweaver–Burk plot
3301:Phosphorylase kinase
1232:that belongs to the
727:response to wounding
600:transferase activity
503:facial motor nucleus
445:orbitofrontal cortex
73:List of PDB id codes
46:Available structures
2181:(43): 29399–29404.
1979:1997PNAS...94.7337T
1835:2002PNAS...9914189L
1570:1998PNAS...95.6881G
1498:www.phosphosite.org
1450:1995Sci...268..286L
737:signal transduction
4237:Enzyme superfamily
4170:Enzyme promiscuity
3912:Tropomyosin kinase
3866:Tau-protein kinase
947:ENSMUSG00000033352
700:Biological process
676:dendrite cytoplasm
659:Cellular component
610:nucleotide binding
593:Molecular function
168:MAP2K4 - orthologs
4393:
4392:
4102:
4101:
4098:
4097:
4094:
4093:
4024:
4023:
4020:
4019:
3400:
3399:
3396:
3395:
2881:Protein kinase N1
2836:Protein kinase Cζ
2227:Landes Bioscience
1206:
1205:
1202:
1201:
1175:
1174:
1140:
1139:
1099:
1098:
1069:
1068:
1028:
1027:
998:
997:
979:
978:
953:
952:
934:
933:
908:
907:
889:
888:
837:
836:
747:apoptotic process
577:
576:
573:
572:
551:
550:
538:
537:
476:
475:
461:prefrontal cortex
441:postcentral gyrus
374:
373:
273:
272:
100:
99:
96:
95:
56:Ortholog search:
4445:
4410:
4409:
4401:
4273:Hanes–Woolf plot
4216:Enzyme activator
4211:Enzyme inhibitor
4185:Enzyme catalysis
4129:
4122:
4115:
4106:
4044:
4030:
3677:C-Jun N-terminal
3420:
3406:
2910:Rhodopsin kinase
2901:Rhodopsin kinase
2831:Protein kinase C
2822:Protein kinase C
2807:Protein kinase G
2768:Protein kinase A
2379:Protein kinase B
2311:
2297:
2273:
2266:
2259:
2250:
2244:
2211:
2210:
2200:
2190:
2166:
2160:
2159:
2149:
2139:
2115:
2109:
2108:
2098:
2066:
2060:
2059:
2049:
2017:
2011:
2010:
2000:
1990:
1958:
1952:
1951:
1941:
1917:
1911:
1910:
1900:
1876:
1867:
1866:
1856:
1846:
1829:(22): 14189–94.
1814:
1808:
1807:
1797:
1773:
1767:
1766:
1756:
1746:
1722:
1716:
1715:
1713:
1712:
1698:
1692:
1691:
1681:
1657:
1651:
1650:
1640:
1608:
1602:
1601:
1591:
1581:
1549:
1543:
1542:
1514:
1508:
1507:
1505:
1504:
1490:
1484:
1483:
1476:
1470:
1469:
1444:(5208): 286–90.
1433:
1427:
1426:
1415:
1409:
1408:
1397:
1391:
1381:
1370:
1360:
1188:
1187:
1159:
1152:
1135:
1103:
1094:
1078:
1074:RefSeq (protein)
1064:
1032:
1023:
1007:
983:
964:
938:
919:
893:
874:
843:
583:
562:
547:
519:secondary oocyte
499:genital tubercle
487:
485:Top expressed in
480:
469:Brodmann area 23
437:Brodmann area 46
425:
423:Top expressed in
418:
397:
380:
370:
357:
346:
331:
324:
318:
307:
295:
279:
269:
256:
245:
230:
223:
217:
206:
192:
176:
170:
121:
114:
91:
70:
64:
43:
42:
37:
25:
4453:
4452:
4448:
4447:
4446:
4444:
4443:
4442:
4418:
4417:
4416:
4404:
4396:
4394:
4389:
4301:Oxidoreductases
4287:
4263:Enzyme kinetics
4251:
4247:List of enzymes
4220:
4189:
4160:Catalytic triad
4138:
4133:
4103:
4090:
4038:
4016:
3940:
3923:
3906:
3889:
3860:
3720:
3620:
3591:P70-S6 Kinase 1
3561:
3452:
3414:
3392:
3358:
3334:
3295:
3261:
2967:
2938:
2914:
2895:
2816:
2792:
2753:
2709:
2692:
2668:
2662:Aurora C kinase
2657:Aurora B kinase
2652:Aurora A kinase
2632:
2613:
2579:
2550:
2483:
2449:
2305:
2291:
2277:
2247:
2241:
2224:
2220:
2218:Further reading
2215:
2214:
2168:
2167:
2163:
2130:(43): 40703–9.
2117:
2116:
2112:
2081:(11): 7539–48.
2068:
2067:
2063:
2019:
2018:
2014:
1973:(14): 7337–42.
1960:
1959:
1955:
1932:(19): 16070–5.
1919:
1918:
1914:
1878:
1877:
1870:
1816:
1815:
1811:
1775:
1774:
1770:
1737:(21): 3369–81.
1724:
1723:
1719:
1710:
1708:
1700:
1699:
1695:
1659:
1658:
1654:
1610:
1609:
1605:
1551:
1550:
1546:
1516:
1515:
1511:
1502:
1500:
1492:
1491:
1487:
1478:
1477:
1473:
1435:
1434:
1430:
1417:
1416:
1412:
1399:
1398:
1394:
1382:
1373:
1361:
1352:
1347:
1341:
1294:
1286:lymphadenopathy
1264:sites that are
1197:View/Edit Mouse
1192:View/Edit Human
1155:
1148:
1145:Location (UCSC)
1131:
1125:
1121:
1117:
1113:
1109:
1090:
1086:
1060:
1054:
1050:
1046:
1042:
1038:
1019:
1015:
928:ENSG00000065559
821:
707:phosphorylation
695:
654:
620:protein binding
615:kinase activity
543:
534:
529:
525:
521:
517:
513:
509:
505:
501:
497:
483:
472:
467:
465:Achilles tendon
463:
459:
455:
451:
447:
443:
439:
435:
421:
365:
352:
344:
334:
333:
332:
325:
305:
282:Gene location (
264:
251:
243:
233:
232:
231:
224:
202:
179:Gene location (
130:
117:
110:
79:
57:
23:
17:
12:
11:
5:
4451:
4449:
4441:
4440:
4435:
4430:
4420:
4419:
4415:
4414:
4391:
4390:
4388:
4387:
4374:
4361:
4348:
4335:
4322:
4309:
4295:
4293:
4289:
4288:
4286:
4285:
4280:
4275:
4270:
4265:
4259:
4257:
4253:
4252:
4250:
4249:
4244:
4239:
4234:
4228:
4226:
4225:Classification
4222:
4221:
4219:
4218:
4213:
4208:
4203:
4197:
4195:
4191:
4190:
4188:
4187:
4182:
4177:
4172:
4167:
4162:
4157:
4152:
4146:
4144:
4140:
4139:
4134:
4132:
4131:
4124:
4117:
4109:
4100:
4099:
4096:
4095:
4092:
4091:
4089:
4088:
4083:
4078:
4073:
4068:
4063:
4058:
4052:
4050:
4040:
4039:
4033:
4026:
4025:
4022:
4021:
4018:
4017:
4015:
4014:
4009:
4004:
3999:
3994:
3989:
3984:
3979:
3978:
3977:
3972:
3967:
3962:
3951:
3949:
3948:(EC 2.7.11.30)
3942:
3941:
3939:
3938:
3934:
3932:
3931:(EC 2.7.11.29)
3925:
3924:
3922:
3921:
3917:
3915:
3914:(EC 2.7.11.28)
3908:
3907:
3905:
3904:
3900:
3898:
3897:(EC 2.7.11.27)
3891:
3890:
3888:
3887:
3882:
3877:
3871:
3869:
3868:(EC 2.7.11.26)
3862:
3861:
3859:
3858:
3853:
3848:
3847:
3846:
3841:
3836:
3831:
3826:
3821:
3816:
3806:
3805:
3804:
3799:
3794:
3789:
3779:
3778:
3777:
3772:
3767:
3762:
3757:
3752:
3747:
3742:
3731:
3729:
3728:(EC 2.7.11.25)
3722:
3721:
3719:
3718:
3717:
3716:
3711:
3706:
3696:
3695:
3694:
3689:
3684:
3674:
3673:
3672:
3667:
3662:
3657:
3652:
3647:
3642:
3631:
3629:
3628:(EC 2.7.11.24)
3622:
3621:
3619:
3618:
3613:
3608:
3603:
3598:
3593:
3588:
3583:
3578:
3572:
3570:
3569:(EC 2.7.11.23)
3563:
3562:
3560:
3559:
3554:
3549:
3544:
3539:
3534:
3529:
3524:
3519:
3514:
3509:
3504:
3499:
3494:
3489:
3484:
3479:
3474:
3469:
3463:
3461:
3460:(EC 2.7.11.22)
3454:
3453:
3451:
3450:
3445:
3440:
3435:
3429:
3427:
3426:(EC 2.7.11.21)
3416:
3415:
3409:
3402:
3401:
3398:
3397:
3394:
3393:
3391:
3390:
3385:
3380:
3375:
3369:
3367:
3366:(EC 2.7.11.21)
3360:
3359:
3357:
3356:
3351:
3345:
3343:
3342:(EC 2.7.11.20)
3336:
3335:
3333:
3332:
3327:
3322:
3317:
3312:
3306:
3304:
3303:(EC 2.7.11.19)
3297:
3296:
3294:
3293:
3288:
3283:
3278:
3272:
3270:
3269:(EC 2.7.11.18)
3263:
3262:
3260:
3259:
3254:
3249:
3244:
3239:
3234:
3229:
3224:
3219:
3214:
3209:
3204:
3199:
3194:
3189:
3184:
3179:
3174:
3169:
3164:
3159:
3154:
3149:
3144:
3139:
3134:
3129:
3124:
3119:
3114:
3109:
3104:
3099:
3094:
3089:
3084:
3079:
3074:
3069:
3064:
3059:
3054:
3049:
3044:
3039:
3034:
3029:
3024:
3019:
3014:
3009:
3004:
2999:
2994:
2989:
2984:
2978:
2976:
2975:(EC 2.7.11.17)
2969:
2968:
2966:
2965:
2960:
2955:
2949:
2947:
2946:(EC 2.7.11.16)
2940:
2939:
2937:
2936:
2931:
2925:
2923:
2922:(EC 2.7.11.15)
2916:
2915:
2913:
2912:
2906:
2904:
2903:(EC 2.7.11.14)
2897:
2896:
2894:
2893:
2888:
2883:
2878:
2873:
2868:
2863:
2858:
2853:
2848:
2843:
2838:
2833:
2827:
2825:
2824:(EC 2.7.11.13)
2818:
2817:
2815:
2814:
2809:
2803:
2801:
2800:(EC 2.7.11.12)
2794:
2793:
2791:
2790:
2785:
2780:
2775:
2770:
2764:
2762:
2761:(EC 2.7.11.11)
2755:
2754:
2752:
2751:
2746:
2741:
2736:
2731:
2726:
2720:
2718:
2717:(EC 2.7.11.10)
2711:
2710:
2708:
2707:
2703:
2701:
2694:
2693:
2691:
2690:
2685:
2679:
2677:
2670:
2669:
2667:
2666:
2665:
2664:
2659:
2654:
2643:
2641:
2634:
2633:
2631:
2630:
2624:
2622:
2615:
2614:
2612:
2611:
2606:
2601:
2596:
2590:
2588:
2581:
2580:
2578:
2577:
2572:
2567:
2561:
2559:
2552:
2551:
2549:
2548:
2547:
2546:
2541:
2536:
2528:
2527:
2526:
2521:
2513:
2512:
2511:
2506:
2494:
2492:
2485:
2484:
2482:
2481:
2476:
2471:
2466:
2460:
2458:
2451:
2450:
2448:
2447:
2446:
2445:
2435:
2434:
2433:
2428:
2423:
2418:
2408:
2403:
2398:
2397:
2396:
2391:
2386:
2376:
2371:
2366:
2361:
2356:
2351:
2346:
2341:
2336:
2331:
2326:
2320:
2318:
2307:
2306:
2300:
2293:
2292:
2278:
2276:
2275:
2268:
2261:
2253:
2246:
2245:
2240:978-1587061202
2239:
2221:
2219:
2216:
2213:
2212:
2161:
2110:
2061:
2032:(7): 2334–42.
2012:
1953:
1912:
1868:
1809:
1768:
1717:
1693:
1652:
1603:
1564:(12): 6881–6.
1544:
1509:
1494:"MKK4 (human)"
1485:
1471:
1428:
1410:
1392:
1371:
1349:
1348:
1346:
1343:
1339:
1338:
1332:
1326:
1320:
1314:
1308:
1293:
1290:
1266:phosphorylated
1204:
1203:
1200:
1199:
1194:
1184:
1183:
1177:
1176:
1173:
1172:
1170:
1168:
1161:
1160:
1153:
1146:
1142:
1141:
1138:
1137:
1127:
1126:
1100:
1097:
1096:
1082:
1081:
1075:
1071:
1070:
1067:
1066:
1056:
1055:
1029:
1026:
1025:
1011:
1010:
1004:
1000:
999:
996:
995:
987:
986:
980:
977:
976:
968:
967:
961:
955:
954:
951:
950:
942:
941:
935:
932:
931:
923:
922:
916:
910:
909:
906:
905:
897:
896:
890:
887:
886:
878:
877:
871:
865:
864:
859:
854:
850:
849:
839:
838:
835:
834:
823:
822:
820:
819:
814:
809:
804:
799:
794:
789:
784:
779:
774:
769:
764:
759:
754:
749:
744:
739:
734:
729:
724:
719:
714:
709:
703:
701:
697:
696:
694:
693:
688:
683:
678:
673:
668:
662:
660:
656:
655:
653:
652:
647:
642:
637:
632:
627:
622:
617:
612:
607:
602:
596:
594:
590:
589:
579:
578:
575:
574:
571:
570:
567:
566:
559:
553:
552:
549:
548:
540:
539:
536:
535:
533:
532:
528:
524:
520:
516:
512:
508:
504:
500:
496:
492:
489:
488:
477:
474:
473:
471:
470:
466:
462:
458:
454:
450:
446:
442:
438:
434:
430:
427:
426:
414:
413:
405:
394:
388:
387:
384:RNA expression
376:
375:
372:
371:
363:
359:
358:
350:
347:
342:
336:
335:
326:
319:
313:
309:
308:
303:
297:
296:
288:
287:
275:
274:
271:
270:
262:
258:
257:
249:
246:
241:
235:
234:
225:
218:
212:
208:
207:
200:
194:
193:
185:
184:
172:
171:
128:
124:
123:
115:
107:
106:
102:
101:
98:
97:
94:
93:
75:
74:
66:
65:
54:
48:
47:
39:
38:
30:
29:
19:Main article:
15:
13:
10:
9:
6:
4:
3:
2:
4450:
4439:
4436:
4434:
4431:
4429:
4426:
4425:
4423:
4413:
4408:
4403:
4399:
4385:
4381:
4380:
4375:
4372:
4368:
4367:
4362:
4359:
4355:
4354:
4349:
4346:
4342:
4341:
4336:
4333:
4329:
4328:
4323:
4320:
4316:
4315:
4310:
4307:
4303:
4302:
4297:
4296:
4294:
4290:
4284:
4281:
4279:
4276:
4274:
4271:
4269:
4266:
4264:
4261:
4260:
4258:
4254:
4248:
4245:
4243:
4242:Enzyme family
4240:
4238:
4235:
4233:
4230:
4229:
4227:
4223:
4217:
4214:
4212:
4209:
4207:
4206:Cooperativity
4204:
4202:
4199:
4198:
4196:
4192:
4186:
4183:
4181:
4178:
4176:
4173:
4171:
4168:
4166:
4165:Oxyanion hole
4163:
4161:
4158:
4156:
4153:
4151:
4148:
4147:
4145:
4141:
4137:
4130:
4125:
4123:
4118:
4116:
4111:
4110:
4107:
4087:
4084:
4082:
4079:
4077:
4074:
4072:
4069:
4067:
4064:
4062:
4059:
4057:
4054:
4053:
4051:
4049:
4045:
4041:
4036:
4031:
4027:
4013:
4010:
4008:
4005:
4003:
4000:
3998:
3995:
3993:
3990:
3988:
3985:
3983:
3980:
3976:
3973:
3971:
3968:
3966:
3963:
3961:
3958:
3957:
3956:
3953:
3952:
3950:
3947:
3943:
3936:
3935:
3933:
3930:
3926:
3919:
3918:
3916:
3913:
3909:
3902:
3901:
3899:
3896:
3892:
3886:
3883:
3881:
3878:
3876:
3873:
3872:
3870:
3867:
3863:
3857:
3854:
3852:
3849:
3845:
3842:
3840:
3837:
3835:
3832:
3830:
3827:
3825:
3822:
3820:
3817:
3815:
3812:
3811:
3810:
3807:
3803:
3800:
3798:
3795:
3793:
3790:
3788:
3785:
3784:
3783:
3780:
3776:
3773:
3771:
3768:
3766:
3763:
3761:
3758:
3756:
3753:
3751:
3748:
3746:
3743:
3741:
3738:
3737:
3736:
3733:
3732:
3730:
3727:
3723:
3715:
3712:
3710:
3707:
3705:
3702:
3701:
3700:
3697:
3693:
3690:
3688:
3685:
3683:
3680:
3679:
3678:
3675:
3671:
3668:
3666:
3663:
3661:
3658:
3656:
3653:
3651:
3648:
3646:
3643:
3641:
3638:
3637:
3636:
3633:
3632:
3630:
3627:
3623:
3617:
3614:
3612:
3609:
3607:
3604:
3602:
3599:
3597:
3594:
3592:
3589:
3587:
3584:
3582:
3579:
3577:
3574:
3573:
3571:
3568:
3564:
3558:
3555:
3553:
3550:
3548:
3545:
3543:
3540:
3538:
3535:
3533:
3530:
3528:
3525:
3523:
3520:
3518:
3515:
3513:
3510:
3508:
3505:
3503:
3500:
3498:
3495:
3493:
3490:
3488:
3485:
3483:
3480:
3478:
3475:
3473:
3470:
3468:
3465:
3464:
3462:
3459:
3455:
3449:
3446:
3444:
3441:
3439:
3436:
3434:
3431:
3430:
3428:
3425:
3421:
3417:
3412:
3407:
3403:
3389:
3386:
3384:
3381:
3379:
3376:
3374:
3371:
3370:
3368:
3365:
3361:
3355:
3352:
3350:
3347:
3346:
3344:
3341:
3337:
3331:
3328:
3326:
3323:
3321:
3318:
3316:
3313:
3311:
3308:
3307:
3305:
3302:
3298:
3292:
3289:
3287:
3284:
3282:
3279:
3277:
3274:
3273:
3271:
3268:
3264:
3258:
3255:
3253:
3250:
3248:
3245:
3243:
3240:
3238:
3235:
3233:
3230:
3228:
3225:
3223:
3220:
3218:
3215:
3213:
3210:
3208:
3205:
3203:
3200:
3198:
3195:
3193:
3190:
3188:
3185:
3183:
3180:
3178:
3175:
3173:
3170:
3168:
3165:
3163:
3160:
3158:
3155:
3153:
3150:
3148:
3145:
3143:
3140:
3138:
3135:
3133:
3130:
3128:
3125:
3123:
3120:
3118:
3115:
3113:
3110:
3108:
3105:
3103:
3100:
3098:
3095:
3093:
3090:
3088:
3085:
3083:
3080:
3078:
3075:
3073:
3070:
3068:
3065:
3063:
3060:
3058:
3055:
3053:
3050:
3048:
3045:
3043:
3040:
3038:
3035:
3033:
3030:
3028:
3025:
3023:
3020:
3018:
3015:
3013:
3010:
3008:
3005:
3003:
3000:
2998:
2995:
2993:
2990:
2988:
2985:
2983:
2980:
2979:
2977:
2974:
2970:
2964:
2961:
2959:
2956:
2954:
2951:
2950:
2948:
2945:
2941:
2935:
2932:
2930:
2927:
2926:
2924:
2921:
2917:
2911:
2908:
2907:
2905:
2902:
2898:
2892:
2889:
2887:
2884:
2882:
2879:
2877:
2874:
2872:
2869:
2867:
2864:
2862:
2859:
2857:
2854:
2852:
2849:
2847:
2844:
2842:
2839:
2837:
2834:
2832:
2829:
2828:
2826:
2823:
2819:
2813:
2810:
2808:
2805:
2804:
2802:
2799:
2795:
2789:
2786:
2784:
2781:
2779:
2776:
2774:
2771:
2769:
2766:
2765:
2763:
2760:
2756:
2750:
2747:
2745:
2742:
2740:
2737:
2735:
2732:
2730:
2727:
2725:
2722:
2721:
2719:
2716:
2712:
2705:
2704:
2702:
2700:(EC 2.7.11.9)
2699:
2695:
2689:
2686:
2684:
2681:
2680:
2678:
2676:(EC 2.7.11.8)
2675:
2671:
2663:
2660:
2658:
2655:
2653:
2650:
2649:
2648:
2647:Aurora kinase
2645:
2644:
2642:
2640:(EC 2.7.11.7)
2639:
2635:
2629:
2626:
2625:
2623:
2621:(EC 2.7.11.6)
2620:
2616:
2610:
2607:
2605:
2602:
2600:
2597:
2595:
2592:
2591:
2589:
2587:(EC 2.7.11.5)
2586:
2582:
2576:
2573:
2571:
2568:
2566:
2563:
2562:
2560:
2558:(EC 2.7.11.4)
2557:
2553:
2545:
2542:
2540:
2537:
2535:
2532:
2531:
2529:
2525:
2522:
2520:
2517:
2516:
2514:
2510:
2507:
2505:
2502:
2501:
2499:
2496:
2495:
2493:
2491:(EC 2.7.11.3)
2490:
2486:
2480:
2477:
2475:
2472:
2470:
2467:
2465:
2462:
2461:
2459:
2457:(EC 2.7.11.2)
2456:
2452:
2444:
2441:
2440:
2439:
2436:
2432:
2429:
2427:
2424:
2422:
2419:
2417:
2414:
2413:
2412:
2411:EIF-2 kinases
2409:
2407:
2404:
2402:
2399:
2395:
2392:
2390:
2387:
2385:
2382:
2381:
2380:
2377:
2375:
2372:
2370:
2367:
2365:
2362:
2360:
2357:
2355:
2352:
2350:
2347:
2345:
2342:
2340:
2337:
2335:
2332:
2330:
2327:
2325:
2322:
2321:
2319:
2317:(EC 2.7.11.1)
2316:
2312:
2308:
2303:
2298:
2294:
2289:
2285:
2281:
2274:
2269:
2267:
2262:
2260:
2255:
2254:
2251:
2242:
2236:
2232:
2228:
2223:
2222:
2217:
2208:
2204:
2199:
2194:
2189:
2184:
2180:
2176:
2172:
2165:
2162:
2157:
2153:
2148:
2143:
2138:
2133:
2129:
2125:
2121:
2114:
2111:
2106:
2102:
2097:
2092:
2088:
2084:
2080:
2076:
2072:
2065:
2062:
2057:
2053:
2048:
2043:
2039:
2035:
2031:
2027:
2023:
2016:
2013:
2008:
2004:
1999:
1994:
1989:
1984:
1980:
1976:
1972:
1968:
1964:
1957:
1954:
1949:
1945:
1940:
1935:
1931:
1927:
1923:
1916:
1913:
1908:
1904:
1899:
1894:
1891:(4): 2573–8.
1890:
1886:
1882:
1875:
1873:
1869:
1864:
1860:
1855:
1850:
1845:
1840:
1836:
1832:
1828:
1824:
1820:
1813:
1810:
1805:
1801:
1796:
1791:
1788:(5): 2620–8.
1787:
1783:
1779:
1772:
1769:
1764:
1760:
1755:
1750:
1745:
1740:
1736:
1732:
1728:
1721:
1718:
1707:
1703:
1697:
1694:
1689:
1685:
1680:
1675:
1672:(5): 625–34.
1671:
1667:
1663:
1656:
1653:
1648:
1644:
1639:
1634:
1630:
1626:
1623:(6): 941–53.
1622:
1618:
1614:
1607:
1604:
1599:
1595:
1590:
1585:
1580:
1575:
1571:
1567:
1563:
1559:
1555:
1548:
1545:
1540:
1536:
1532:
1528:
1525:(3): 505–16.
1524:
1520:
1513:
1510:
1499:
1495:
1489:
1486:
1481:
1475:
1472:
1467:
1463:
1459:
1455:
1451:
1447:
1443:
1439:
1432:
1429:
1424:
1420:
1414:
1411:
1406:
1402:
1396:
1393:
1389:
1385:
1380:
1378:
1376:
1372:
1368:
1364:
1359:
1357:
1355:
1351:
1344:
1342:
1336:
1333:
1330:
1327:
1324:
1321:
1318:
1315:
1312:
1309:
1306:
1303:
1302:
1301:
1299:
1291:
1289:
1287:
1283:
1279:
1275:
1271:
1270:ubiquitinated
1267:
1263:
1259:
1255:
1251:
1247:
1243:
1239:
1235:
1231:
1227:
1223:
1221:
1218:
1214:
1210:
1198:
1193:
1189:
1185:
1182:
1178:
1171:
1169:
1166:
1162:
1158:
1154:
1151:
1147:
1143:
1136:
1134:
1128:
1124:
1120:
1116:
1112:
1108:
1104:
1101:
1095:
1093:
1089:
1083:
1079:
1076:
1072:
1065:
1063:
1057:
1053:
1049:
1045:
1041:
1037:
1033:
1030:
1024:
1022:
1018:
1012:
1008:
1005:
1003:RefSeq (mRNA)
1001:
994:
993:
988:
984:
981:
975:
974:
969:
965:
962:
960:
956:
949:
948:
943:
939:
936:
930:
929:
924:
920:
917:
915:
911:
904:
903:
898:
894:
891:
885:
884:
879:
875:
872:
870:
866:
863:
860:
858:
855:
851:
848:
844:
840:
833:
829:
824:
818:
815:
813:
810:
808:
805:
803:
800:
798:
795:
793:
790:
788:
785:
783:
780:
778:
775:
773:
770:
768:
765:
763:
760:
758:
755:
753:
750:
748:
745:
743:
740:
738:
735:
733:
730:
728:
725:
723:
720:
718:
715:
713:
710:
708:
705:
704:
702:
699:
698:
692:
689:
687:
684:
682:
679:
677:
674:
672:
669:
667:
664:
663:
661:
658:
657:
651:
648:
646:
643:
641:
638:
636:
633:
631:
628:
626:
623:
621:
618:
616:
613:
611:
608:
606:
603:
601:
598:
597:
595:
592:
591:
588:
587:Gene ontology
584:
580:
568:
563:
560:
558:
554:
546:
541:
530:
526:
522:
518:
514:
510:
506:
502:
498:
494:
493:
490:
486:
481:
478:
468:
464:
460:
456:
452:
449:Pars compacta
448:
444:
440:
436:
432:
431:
428:
424:
419:
416:
415:
412:
410:
406:
404:
403:
399:
398:
395:
393:
389:
385:
381:
377:
369:
364:
360:
356:
351:
341:
337:
330:
323:
317:
310:
302:
298:
294:
289:
285:
280:
276:
268:
263:
259:
255:
250:
240:
236:
229:
222:
216:
209:
205:
199:
195:
191:
186:
182:
177:
173:
169:
165:
161:
157:
153:
149:
145:
141:
137:
133:
125:
120:
113:
108:
103:
92:
90:
86:
82:
76:
71:
68:
67:
63:
60:
53:
49:
44:
40:
36:
31:
26:
22:
4379:Translocases
4376:
4363:
4350:
4337:
4324:
4314:Transferases
4311:
4298:
4155:Binding site
4070:
3586:P70S6 kinase
2230:
2226:
2178:
2174:
2164:
2127:
2123:
2113:
2078:
2074:
2064:
2029:
2025:
2015:
1970:
1966:
1956:
1929:
1925:
1915:
1888:
1884:
1826:
1822:
1812:
1785:
1781:
1771:
1734:
1730:
1720:
1709:. Retrieved
1705:
1696:
1669:
1665:
1655:
1620:
1616:
1606:
1561:
1557:
1547:
1522:
1518:
1512:
1501:. Retrieved
1497:
1488:
1474:
1441:
1437:
1431:
1422:
1413:
1404:
1395:
1340:
1295:
1292:Interactions
1281:
1277:
1273:
1225:
1224:
1216:
1208:
1207:
1133:NP_001349669
1130:
1123:NP_001349668
1115:NP_001303298
1111:NP_001303297
1107:NP_001303296
1088:NP_001268364
1085:
1062:NM_001362740
1059:
1052:NM_001362739
1048:NM_001316369
1044:NM_001316368
1040:NM_001316367
1017:NM_001281435
1014:
990:
971:
945:
926:
900:
881:
861:
856:
712:MAPK cascade
407:
400:
127:External IDs
78:
4150:Active site
4037:(EC 2.7.12)
3424:Polo kinase
3364:Polo kinase
1519:Development
1248:/JNK2, and
1238:MAP kinases
767:JNK cascade
630:ATP binding
527:granulocyte
366:65,679,123
353:65,579,069
265:12,143,830
252:12,020,829
105:Identifiers
4422:Categories
4353:Isomerases
4327:Hydrolases
4194:Regulation
2715:IκB kinase
2290:2.7.11-12)
1711:2020-12-26
1503:2020-10-28
1390:, May 2017
1369:, May 2017
1345:References
1262:amino acid
1228:encodes a
686:perikaryon
411:(ortholog)
148:HomoloGene
4438:EC 2.7.11
4232:EC number
2841:PKC alpha
2147:2297/2692
1119:NP_033183
1092:NP_003001
1036:NM_009157
1021:NM_003010
847:Orthologs
666:cytoplasm
156:GeneCards
4256:Kinetics
4180:Cofactor
4143:Activity
3197:KIAA0999
3092:MAPKAPK5
3087:MAPKAPK3
3082:MAPKAPK2
2233:: 1–97.
2207:19737936
2156:12189133
2105:10523642
2056:10713157
1948:11279118
1907:11707464
1863:12391307
1666:Immunity
1386:–
1365:–
1323:MAPK8IP3
1298:interact
1181:Wikidata
826:Sources:
4412:Biology
4366:Ligases
4136:Enzymes
3856:MAP3K14
3834:MAP3K11
3829:MAP3K10
3819:MAP3K13
3814:MAP3K12
3616:RPS6KC1
3611:RPS6KA1
3606:RPS6KA3
3601:RPS6KA2
3596:RPS6KB2
3581:RPS6KA4
3576:RPS6KA5
3227:Kalirin
3192:SNF1LK2
2431:EIF2AK4
2426:EIF2AK3
2280:Kinases
2198:2785572
2007:9207092
1975:Bibcode
1831:Bibcode
1804:9006895
1763:9808624
1688:9620683
1647:9294148
1638:2199046
1598:9618507
1566:Bibcode
1539:9876179
1466:7716521
1446:Bibcode
1438:Science
1388:Ensembl
1367:Ensembl
1300:with:
1244:/JNK1,
959:UniProt
914:Ensembl
853:Species
832:QuickGO
681:cytosol
671:nucleus
386:pattern
144:1346869
112:Aliases
4398:Portal
4340:Lyases
4086:MAP2K7
4081:MAP2K6
4076:MAP2K5
4071:MAP2K4
4066:MAP2K3
4061:MAP2K2
4056:MAP2K1
4007:ACVRL1
4002:ACVR2B
3997:ACVR2A
3992:ACVR1C
3987:ACVR1B
3970:BMPR1B
3965:BMPR1A
3839:MAP3K7
3824:MAP3K9
3775:MAP3K8
3770:MAP3K7
3765:MAP3K6
3760:MAP3K5
3755:MAP3K4
3750:MAP3K3
3745:MAP3K2
3740:MAP3K1
3714:MAPK14
3709:MAPK13
3704:MAPK11
3692:MAPK10
3670:MAPK15
3665:MAPK12
3557:CDC2L1
3532:CDC2L5
3207:SNF1LK
3032:CAMK2G
3027:CAMK2D
3022:CAMK2B
3017:CAMK2A
3007:CAMK1G
3002:CAMK1D
2997:CAMK1B
2992:CAMK1A
2846:PRKCB1
2783:PRKACA
2778:PRKACB
2773:PRKACG
2749:IKBKAP
2575:BCKDHB
2570:BCKDHA
2544:PRKAG3
2539:PRKAG2
2534:PRKAG1
2524:PRKAB2
2519:PRKAB1
2509:PRKAA2
2504:PRKAA1
2349:STK38L
2237:
2205:
2195:
2154:
2103:
2093:
2054:
2044:
2005:
1995:
1946:
1905:
1861:
1854:137859
1851:
1802:
1761:
1754:317229
1751:
1686:
1645:
1635:
1596:
1586:
1537:
1464:
1305:MAP3K1
1282:Map2k4
1278:Map2k4
1274:Map2k4
1258:MAP3K1
1254:kinase
1250:MAPK14
1226:MAP2K4
1217:MAP2K4
1213:enzyme
1211:is an
1167:search
1165:PubMed
992:P47809
973:P45985
869:Entrez
557:BioGPS
160:MAP2K4
136:601335
119:MAP2K4
28:MAP2K4
4292:Types
4048:MAP2K
3982:ACVR1
3975:BMPR2
3960:BMPR1
3885:GSK-3
3726:MAP3K
3687:MAPK9
3682:MAPK8
3660:MAPK7
3655:MAPK6
3650:MAPK4
3645:MAPK3
3640:MAPK1
3552:PFTK1
3547:PCTK3
3542:PCTK2
3537:PCTK1
3527:CDK12
3522:CDK10
3497:CDKL5
3477:CDKL2
3354:STK19
3349:EEF2K
3330:PHKG2
3325:PHKG1
3315:PHKA2
3310:PHKA1
3291:MYLK4
3286:MYLK3
3281:MYLK2
3257:DCLK1
3252:Titin
3242:TRIB3
3237:TRIB2
3232:TRIB1
3222:TSSK2
3202:STK40
3187:PSKH1
3182:PRKD3
3177:PRKD2
3157:PHKG2
3152:PHKG1
3142:OBSCN
3137:NUAK2
3132:NUAK1
3127:MKNK2
3122:MKNK1
3112:MARK4
3107:MARK3
3102:MARK2
3097:MARK1
3077:STK11
3072:DAPK3
3067:DAPK2
3062:DAPK1
3057:CHEK2
3052:CHEK1
3037:CAMK4
3012:CAMK2
2987:CAMK1
2982:BRSK2
2876:PRKCQ
2871:PRKCI
2866:PRKCG
2861:PRKCH
2856:PRKCE
2851:PRKCD
2812:PRKG1
2744:IKBKG
2739:IKBKE
2688:STK10
2683:FASTK
2609:IDH3G
2604:IDH3B
2599:IDH3A
2565:BCKDK
2359:ROCK1
2344:STK38
2339:MAST2
2334:MAST1
2329:LATS2
2324:LATS1
2096:84763
2047:85399
1998:23822
1589:22670
1317:MAPK8
1246:MAPK9
1242:MAPK8
902:26398
862:Mouse
857:Human
828:Amigo
409:Mouse
402:Human
349:Start
284:Mouse
248:Start
244:17p12
181:Human
152:48159
4384:list
4377:EC7
4371:list
4364:EC6
4358:list
4351:EC5
4345:list
4338:EC4
4332:list
4325:EC3
4319:list
4312:EC2
4306:list
4299:EC1
3875:TPK1
3851:CDC7
3809:MLKs
3802:KSR2
3797:KSR1
3792:BRAF
3787:ARAF
3782:RAFs
3517:CDK9
3512:CDK8
3507:CDK7
3502:CDK6
3492:CDK5
3487:CDK4
3482:CDK3
3472:CDK2
3467:CDK1
3448:PLK4
3443:PLK3
3438:PLK2
3433:PLK1
3388:PLK4
3383:PLK3
3378:PLK2
3373:PLK1
3320:PHKB
3276:MYLK
3247:TRIO
3217:SPEG
3212:SNRK
3172:PKD1
3167:PIM2
3162:PIM1
3147:PASK
3117:MELK
3047:CASK
3042:MLCK
2963:GRK6
2958:GRK5
2953:GRK4
2891:PKN3
2886:PKN2
2788:PRKY
2734:TBK1
2729:IKK2
2724:CHUK
2628:STK4
2594:IDH2
2479:PDK4
2474:PDK3
2469:PDK2
2464:PDK1
2443:WEE1
2438:Wee1
2406:mTOR
2394:AKT3
2389:AKT2
2384:AKT1
2374:SGK3
2369:SGK2
2235:ISBN
2203:PMID
2152:PMID
2101:PMID
2052:PMID
2003:PMID
1944:PMID
1903:PMID
1859:PMID
1800:PMID
1759:PMID
1684:PMID
1643:PMID
1594:PMID
1535:PMID
1462:PMID
1335:ITCH
1329:AKT1
1311:FLNC
1268:and
1220:gene
883:6416
691:axon
392:Bgee
340:Band
301:Chr.
239:Band
198:Chr.
132:OMIM
89:3VUT
85:3ALO
81:3ALN
62:RCSB
59:PDBe
3880:TTK
3844:ZAK
2421:HRI
2416:PKR
2364:SGK
2354:CIT
2193:PMC
2183:doi
2179:284
2142:hdl
2132:doi
2128:277
2091:PMC
2083:doi
2042:PMC
2034:doi
1993:PMC
1983:doi
1934:doi
1930:276
1893:doi
1889:277
1849:PMC
1839:doi
1790:doi
1786:272
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1739:doi
1674:doi
1633:PMC
1625:doi
1621:186
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