2548:
328:
305:
202:
227:
2533:
579:
35:
334:
233:
2563:
4740:
1167:
This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse MEKK3. Its catalytic domain is closely related to those of several other kinases, including mouse MEKK2, tobacco NPK, and yeast STE11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously
1256:
induces MEKK3 activity and it requires functional BRCA1 to do it. It was observed that in a breast cancer cell line BRCA1-deficient (HCC1937), paclitaxel was unable to activate MEKK3. Paclitaxel may be inducing stress-response through the MEKK3/JNK/p38/MAPK pathway, but not in mutated BRCA1 cells.
1175:
by activating SEK and MEK1/2 respectively. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NF-κB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. MEKK3
1648:
Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B,
2064:
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001).
2547:
61:
1244:
have increased expression in most cancer cells with high levels of MEKK3. This is probably due to constitutive activation of NFκB, which will regulate those genes. In this sense, knockdown of MEKK3 caused ovarian cancer cells to be more sensitive to drugs.
1240:. High expression of MEKK3 in most of these ovarian cancer cells supposedly activate IKK kinase activity, which lead to increased levels of active NFκB. Also, MEKK3 interacts with AKT to activate NFκB. Genes related to cell survival and anti-
1231:
MEKK3 is highly expressed in 4 ovarian cancer cell lines (OVCA429, Hey, DOV13, and SKOv3). This expression level is significantly higher in those cancer cells when compared to normal cells. MEKK3 expression levels are comparable to IKK
1353:"Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 (MEKK) derivative"
2603:
2888:
2532:
2190:"Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells: role of Gab1 and MEKK3 in TNF-alpha-induced c-Jun and NF-kappaB activation and adhesion molecule expression"
1568:"Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells: role of Gab1 and MEKK3 in TNF-alpha-induced c-Jun and NF-kappaB activation and adhesion molecule expression"
2556:: Crystal Structure of the Complex of Human Mitogen Activated Protein Kinase Kinase 5 Phox Domain (MAP2K5-phox) with Human Mitogen Activated Protein Kinase Kinase Kinase 3 (MAP3K3B-phox)
2596:
1850:
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".
2589:
341:
240:
2796:
2375:
Huang Q, Yang J, Lin Y, Walker C, Cheng J, Liu ZG, Su B (Jan 2004). "Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3".
3344:
4183:
2647:
4292:
2151:
Yang J, Lin Y, Guo Z, Cheng J, Huang J, Deng L, Liao W, Chen Z, Liu Z, Su B (Jul 2001). "The essential role of MEKK3 in TNF-induced NF-kappaB activation".
1473:
Gilmore PM, McCabe N, Quinn JE, Kennedy RD, Gorski JJ, Andrews HN, McWilliams S, Carty M, Mullan PB, Duprex WP, Liu ET, Johnston PG, Harkin DP (Jun 2004).
3030:
2917:
862:
163:
3305:
843:
1171:
MAP3Ks are involved in regulating cell fate in response to external stimuli. MAP3K3 directly regulates the stress-activated protein kinase (SAPK) and
4278:
3743:
2634:
2616:
4380:
4261:
1949:
Yang J, Boerm M, McCarty M, Bucana C, Fidler IJ, Zhuang Y, Su B (Mar 2000). "Mekk3 is essential for early embryonic cardiovascular development".
3967:
2836:
1786:
Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".
4760:
4031:
3006:
2512:
1333:
2305:
Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (May 2003).
1315:
4287:
2449:"MEKK3 initiates transforming growth factor beta 2-dependent epithelial-to-mesenchymal transition during endocardial cushion morphogenesis"
1519:"MEKK3 expression correlates with nuclear factor kappa B activity and with expression of antiapoptotic genes in serous ovarian carcinoma"
327:
2821:
1093:
4344:
4019:
1086:
2562:
304:
4459:
3276:
3266:
2951:
3958:
1456:
2276:
Adams DG, Sachs NA, Vaillancourt RR (Nov 2002). "Phosphorylation of the stress-activated protein kinase, MEKK3, at serine 166".
4227:
3899:
3261:
3252:
1302:
1281:
226:
201:
4615:
1475:"BRCA1 interacts with and is required for paclitaxel-induced activation of mitogen-activated protein kinase kinase kinase 3"
1298:
1649:
Superti-Furga G (Feb 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway".
58:
3642:
3139:
3130:
2787:
2733:
4730:
1277:
2830:
2541:: CRYSTAL STRUCTURE OF HUMAN MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3 ISOFORM 2 PHOX DOMAIN AT 1.25 A RESOLUTION
2188:
Che W, Lerner-Marmarosh N, Huang Q, Osawa M, Ohta S, Yoshizumi M, Glassman M, Lee JD, Yan C, Berk BC, Abe J (Jun 2002).
2067:"Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs"
1566:
Che W, Lerner-Marmarosh N, Huang Q, Osawa M, Ohta S, Yoshizumi M, Glassman M, Lee JD, Yan C, Berk BC, Abe J (Jun 2002).
143:
1916:"MEKK3 directly regulates MEK5 activity as part of the big mitogen-activated protein kinase 1 (BMK1) signaling pathway"
1185:
340:
239:
2581:
2307:"Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways"
3854:
3672:
3168:
333:
232:
4600:
4716:
4703:
4690:
4677:
4664:
4651:
4638:
3844:
3839:
3834:
3824:
3819:
3814:
3804:
3599:
3374:
2970:
2505:
4610:
4564:
4507:
4067:
4058:
4009:
2775:
2620:
907:
151:
20:
4512:
4367:
3790:
888:
4533:
4452:
3066:
215:
4605:
3633:
2498:
2342:"PB1 domains of MEKK2 and MEKK3 interact with the MEK5 PB1 domain for activation of the ERK5 pathway"
2236:
1986:
Sun W, Kesavan K, Schaefer BC, Garrington TP, Ware M, Johnson NL, Gelfand EW, Johnson GL (Feb 2001).
1607:
Sun W, Kesavan K, Schaefer BC, Garrington TP, Ware M, Johnson NL, Gelfand EW, Johnson GL (Feb 2001).
130:
4569:
1048:
1036:
989:
985:
4141:
4765:
4502:
4244:
4198:
2400:
2225:"JLP: A scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors"
2176:
2110:"Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing"
1974:
1674:
1438:
175:
1069:
1044:
1040:
1010:
981:
977:
3504:
3213:
2478:
2435:
2392:
2363:
2328:
2293:
2264:
2211:
2168:
2139:
2096:
2052:
2009:
1966:
1937:
1902:
1867:
1838:
1803:
1764:
1715:
1666:
1630:
1589:
1548:
1496:
1430:
1374:
123:
51:
1988:"MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway"
1609:"MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway"
4548:
4543:
4517:
4445:
4097:
3339:
3329:
3324:
3242:
3233:
3163:
3154:
3100:
3091:
2748:
2468:
2460:
2425:
2384:
2353:
2318:
2285:
2254:
2244:
2201:
2160:
2129:
2121:
2086:
2078:
2042:
2034:
1999:
1958:
1927:
1892:
1859:
1828:
1795:
1754:
1746:
1705:
1658:
1620:
1579:
1538:
1530:
1486:
1420:
1392:
1364:
1172:
578:
420:
351:
295:
250:
171:
4595:
4579:
4492:
3923:
2994:
2989:
2984:
395:
2414:"Overexpression of MEKK3 confers resistance to apoptosis through activation of NFkappaB"
2240:
34:
4744:
4633:
4574:
2473:
2448:
2206:
2189:
2134:
2109:
1759:
1734:
1584:
1567:
1543:
1518:
2447:
Stevens MV, Broka DM, Parker P, Rogowitz E, Vaillancourt RR, Camenisch TD (Dec 2008).
2289:
2259:
2224:
2091:
2066:
2047:
2022:
1863:
777:
772:
767:
762:
757:
752:
747:
742:
737:
732:
727:
722:
717:
712:
707:
702:
697:
681:
676:
660:
655:
650:
645:
640:
635:
630:
625:
620:
4754:
4538:
4497:
3047:
2979:
1799:
607:
2404:
2180:
1978:
1678:
155:
4487:
3918:
2743:
1879:
Fanger GR, Widmann C, Porter AC, Sather S, Johnson GL, Vaillancourt RR (Feb 1998).
1692:
Fanger GR, Widmann C, Porter AC, Sather S, Johnson GL, Vaillancourt RR (Feb 1998).
413:
192:
2464:
2125:
1491:
1474:
1442:
179:
4711:
4646:
4482:
4124:
3756:
3696:
3579:
3499:
3223:
1338:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1320:
National Center for
Biotechnology Information, U.S. National Library of Medicine
4739:
2229:
Proceedings of the
National Academy of Sciences of the United States of America
496:
4212:
2686:
1253:
312:
209:
159:
1932:
1915:
1228:
gene were found as candidates for association with colon and rectal cancers.
4685:
4659:
3173:
1817:"Normalization and subtraction: two approaches to facilitate gene discovery"
1750:
1252:. Knocking down BRCA1 resulted in inhibited MEKK3 kinase activity. The drug
1241:
807:
556:
434:
379:
366:
278:
265:
167:
2482:
2439:
2430:
2413:
2396:
2367:
2358:
2341:
2332:
2323:
2306:
2297:
2268:
2249:
2215:
2172:
2143:
2108:
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000).
2100:
2056:
2013:
2004:
1987:
1970:
1941:
1897:
1880:
1768:
1710:
1693:
1670:
1634:
1625:
1608:
1593:
1552:
1500:
1434:
1369:
1352:
1906:
1871:
1842:
1807:
1719:
1378:
1133:
1128:
3529:
3424:
3419:
3414:
1117:
952:
933:
1517:
Samanta AK, Huang HJ, Le XF, Mao W, Lu KH, Bast RC, Liao WS (Sep 2009).
768:
positive regulation of cell migration involved in sprouting angiogenesis
4188:
4166:
4161:
4151:
4146:
3948:
3943:
3938:
3933:
3928:
3913:
3908:
3559:
3524:
2763:
2758:
2753:
2082:
1833:
1816:
1534:
1425:
1408:
1237:
919:
874:
2038:
1457:"Entrez Gene: MAP3K3 mitogen-activated protein kinase kinase kinase 3"
100:
96:
92:
88:
84:
80:
4698:
4468:
4418:
4413:
4408:
4403:
4398:
4393:
4388:
4339:
4334:
4329:
4324:
4319:
4302:
4297:
4171:
4156:
4107:
4102:
4087:
4077:
4072:
4046:
4041:
4036:
4024:
4002:
3997:
3889:
3864:
3539:
3364:
3359:
3354:
3349:
3334:
3178:
3115:
3110:
3105:
3081:
2907:
2902:
2876:
2871:
2866:
2856:
2851:
2841:
2681:
2612:
1233:
1205:
1149:
1101:
829:
1662:
2388:
1351:
Ellinger-Ziegelbauer H, Brown K, Kelly K, Siebenlist U (Jan 1997).
4672:
4314:
4307:
4217:
4114:
4014:
3992:
3987:
3982:
3977:
3972:
3884:
3879:
3874:
3869:
3859:
3829:
3809:
3686:
3681:
3662:
3657:
3647:
3623:
3618:
3613:
3589:
3584:
3574:
3569:
3564:
3554:
3534:
3519:
3514:
3509:
3489:
3484:
3474:
3469:
3464:
3459:
3454:
3444:
3439:
3434:
3429:
3409:
3404:
3399:
3394:
3389:
3384:
3369:
3319:
3314:
3208:
3203:
3198:
3193:
3188:
3183:
3144:
3076:
3071:
3020:
3015:
2941:
2936:
2931:
2897:
2889:
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase
2691:
2676:
2671:
2666:
2661:
2656:
2223:
Lee CM, Onésime D, Reddy CD, Dhanasekaran N, Reddy EP (Oct 2002).
2164:
1962:
1249:
1211:
1193:
134:, MAPKKK3, MEKK3, mitogen-activated protein kinase kinase kinase 3
792:
788:
4207:
4134:
4129:
4119:
4092:
3849:
3799:
3780:
3775:
3770:
3765:
3720:
3715:
3710:
3705:
3652:
3608:
3549:
3544:
3494:
3479:
3449:
3379:
3295:
3290:
3285:
3218:
3120:
3061:
3056:
2960:
2926:
2811:
2806:
2801:
2770:
2738:
2726:
2721:
2716:
2706:
2701:
1199:
1156:
147:
4441:
4365:
3741:
2632:
2585:
2494:
1159:, which is located on the long arm of chromosome 17 (17q23.3).
587:
4176:
2711:
2696:
2490:
1409:"MAP3Ks as central regulators of cell fate during development"
1173:
extracellular signal-regulated protein kinase (ERK) pathways
1914:
Chao TH, Hayashi M, Tapping RI, Kato Y, Lee JD (Dec 1999).
1407:
Craig EA, Stevens MV, Vaillancourt RR, et al. (2008).
4437:
728:
positive regulation of I-kappaB kinase/NF-kappaB signaling
1393:
https://www.genecards.org/cgi-bin/carddisp.pl?gene=MAP3K3
2023:"DNA cloning using in vitro site-specific recombination"
763:
positive regulation of cell proliferation in bone marrow
403:
4728:
568:
1881:"14-3-3 proteins interact with specific MEK kinases"
1694:"14-3-3 proteins interact with specific MEK kinases"
4624:
4588:
4557:
4526:
4475:
4379:
4277:
4260:
4243:
4226:
4197:
4057:
3957:
3898:
3789:
3755:
3695:
3671:
3632:
3598:
3304:
3275:
3251:
3232:
3153:
3129:
3090:
3046:
3029:
3005:
2969:
2950:
2916:
2887:
2820:
2786:
2646:
2412:Samanta AK, Huang HJ, Bast RC, Liao WS (Feb 2004).
1062:
1029:
1003:
970:
1294:
1292:
1290:
1273:
1271:
1269:
1391:MAP3K3 in GeneCards – The Human Gene Compendium.
738:stress-activated protein kinase signaling cascade
350:
249:
1146:Mitogen-activated protein kinase kinase kinase 3
1236:activities, which also relate to activation of
16:Protein-coding gene in the species Homo sapiens
2571:: solution structure of human MEKK3 PB1 domain
1735:"MAP kinase genes and colon and rectal cancer"
1468:
1466:
1299:GRCm38: Ensembl release 89: ENSMUSG00000020700
4453:
2648:Non-specific serine/threonine protein kinases
2597:
2506:
2021:Hartley JL, Temple GF, Brasch MA (Nov 2000).
8:
1815:Bonaldo MF, Lennon G, Soares MB (Sep 1996).
1176:regulates the p38, JNK and ERK1/2 pathways.
1733:Slattery ML, Lundgreen A, Wolff RK (2012).
1278:GRCh38: Ensembl release 89: ENSG00000198909
4460:
4446:
4438:
4376:
4362:
3752:
3738:
3031:Goodpasture-antigen-binding protein kinase
2643:
2629:
2604:
2590:
2582:
2513:
2499:
2491:
803:
773:negative regulation of cellular senescence
603:
391:
290:
187:
69:
3744:Serine/threonine-specific protein kinases
2918:(isocitrate dehydrogenase (NADP+)) kinase
2635:Serine/threonine-specific protein kinases
2617:Serine/threonine-specific protein kinases
2472:
2429:
2357:
2322:
2258:
2248:
2205:
2133:
2090:
2046:
2003:
1931:
1896:
1832:
1758:
1709:
1624:
1583:
1542:
1490:
1424:
1368:
4279:Receptor protein serine/threonine kinase
758:interleukin-1-mediated signaling pathway
661:protein serine/threonine kinase activity
4735:
4262:Low-density-lipoprotein receptor kinase
2528:
2278:Archives of Biochemistry and Biophysics
1265:
708:positive regulation of p38MAPK cascade
24:
3007:Fas-activated serine/threonine kinase
1512:
1510:
743:activation of protein kinase activity
355:
316:
311:
254:
213:
208:
7:
4288:Bone morphogenetic protein receptors
1402:
1400:
2822:Dephospho-(reductase kinase) kinase
2418:The Journal of Biological Chemistry
2346:The Journal of Biological Chemistry
2340:Nakamura K, Johnson GL (Sep 2003).
1992:The Journal of Biological Chemistry
1920:The Journal of Biological Chemistry
1885:The Journal of Biological Chemistry
1698:The Journal of Biological Chemistry
1613:The Journal of Biological Chemistry
1357:The Journal of Biological Chemistry
3277:G-protein coupled receptor kinases
2207:10.1161/01.RES.0000021127.83364.7D
1585:10.1161/01.RES.0000021127.83364.7D
1059:
1026:
1000:
967:
943:
924:
898:
879:
853:
834:
573:
491:
429:
408:
14:
3267:Beta adrenergic receptor kinase-2
2952:(tyrosine 3-monooxygenase) kinase
1152:that in humans is encoded by the
698:intracellular signal transduction
636:MAP kinase kinase kinase activity
4738:
3959:Mitogen-activated protein kinase
2561:
2546:
2531:
733:regulation of mitotic cell cycle
577:
339:
332:
326:
303:
238:
231:
225:
200:
33:
4345:Anti-Müllerian hormone receptor
4228:(acetyl-CoA carboxylase) kinase
3900:(RNA-polymerase)-subunit kinase
3262:Beta adrenergic receptor kinase
3253:Beta adrenergic receptor kinase
748:regulation of apoptotic process
3968:Extracellular signal-regulated
588:More reference expression data
557:More reference expression data
1:
4032:P38 mitogen-activated protein
3131:cGMP-dependent protein kinase
3092:cAMP-dependent protein kinase
2788:Pyruvate dehydrogenase kinase
2734:Ataxia telangiectasia mutated
2465:10.1161/CIRCRESAHA.108.180752
2290:10.1016/S0003-9861(02)00464-2
1864:10.1016/S0378-1119(97)00411-3
1492:10.1158/0008-5472.CAN-03-4080
539:tunica media of zone of aorta
324:
223:
4761:Genes on human chromosome 17
2831:AMP-activated protein kinase
1800:10.1016/0378-1119(94)90802-8
3746:(EC 2.7.11.21-EC 2.7.11.30)
2126:10.1093/embo-reports/kvd058
713:protein autophosphorylation
4782:
3673:Elongation factor 2 kinase
2637:(EC 2.7.11.1-EC 2.7.11.20)
1248:MEKK3 also interacts with
1094:Chr 11: 105.98 – 106.05 Mb
18:
4616:Michaelis–Menten kinetics
4375:
4361:
4068:MAP kinase kinase kinases
3751:
3737:
3600:Myosin light-chain kinase
3306:Ca2+/calmodulin-dependent
2971:Myosin-heavy-chain kinase
2642:
2628:
2526:
1334:"Mouse PubMed Reference:"
1316:"Human PubMed Reference:"
1184:MAP3K3 has been shown to
1132:
1127:
1123:
1116:
1100:
1081:
1066:
1033:
1022:
1007:
974:
963:
950:
946:
931:
927:
918:
905:
901:
886:
882:
873:
860:
856:
841:
837:
828:
813:
806:
802:
786:
606:
602:
585:
576:
567:
554:
503:
494:
441:
432:
402:
394:
390:
373:
360:
323:
302:
293:
289:
272:
259:
222:
199:
190:
186:
141:
138:
128:
121:
116:
77:
72:
55:
50:
45:
41:
32:
27:
4508:Diffusion-limited enzyme
4368:Dual-specificity kinases
1933:10.1074/jbc.274.51.36035
718:blood vessel development
531:Rostral migratory stream
21:MAP kinase kinase kinase
3791:Cyclin-dependent kinase
1087:Chr 17: 63.62 – 63.7 Mb
703:protein phosphorylation
626:protein kinase activity
523:external carotid artery
511:internal carotid artery
2431:10.1074/jbc.M311659200
2359:10.1074/jbc.C300313200
2324:10.1038/sj.onc.1206406
2250:10.1073/pnas.232310199
2005:10.1074/jbc.M003719200
1898:10.1074/jbc.273.6.3476
1711:10.1074/jbc.273.6.3476
1626:10.1074/jbc.M003719200
1413:Developmental Dynamics
1370:10.1074/jbc.272.5.2668
4601:Eadie–Hofstee diagram
4534:Allosteric regulation
1751:10.1093/carcin/bgs305
469:right coronary artery
318:Chromosome 11 (mouse)
216:Chromosome 17 (human)
4611:Lineweaver–Burk plot
3634:Phosphorylase kinase
2453:Circulation Research
2194:Circulation Research
1572:Circulation Research
656:transferase activity
73:List of PDB id codes
46:Available structures
2241:2002PNAS...9914189L
1651:Nature Cell Biology
778:signal transduction
4570:Enzyme superfamily
4503:Enzyme promiscuity
4245:Tropomyosin kinase
4199:Tau-protein kinase
2083:10.1101/gr.GR1547R
1834:10.1101/gr.6.9.791
1535:10.1002/cncr.24445
1426:10.1002/dvdy.21750
908:ENSMUSG00000020700
691:Biological process
670:Cellular component
651:nucleotide binding
614:Molecular function
180:MAP3K3 - orthologs
4726:
4725:
4435:
4434:
4431:
4430:
4427:
4426:
4357:
4356:
4353:
4352:
3733:
3732:
3729:
3728:
3214:Protein kinase N1
3169:Protein kinase Cζ
2579:
2578:
2377:Nature Immunology
2153:Nature Immunology
2039:10.1101/gr.143000
1143:
1142:
1139:
1138:
1112:
1111:
1077:
1076:
1056:
1055:
1018:
1017:
997:
996:
959:
958:
940:
939:
914:
913:
895:
894:
869:
868:
850:
849:
798:
797:
646:metal ion binding
598:
597:
594:
593:
563:
562:
550:
549:
488:
487:
386:
385:
285:
284:
112:
111:
108:
107:
56:Ortholog search:
4773:
4743:
4742:
4734:
4606:Hanes–Woolf plot
4549:Enzyme activator
4544:Enzyme inhibitor
4518:Enzyme catalysis
4462:
4455:
4448:
4439:
4377:
4363:
4010:C-Jun N-terminal
3753:
3739:
3243:Rhodopsin kinase
3234:Rhodopsin kinase
3164:Protein kinase C
3155:Protein kinase C
3140:Protein kinase G
3101:Protein kinase A
2712:Protein kinase B
2644:
2630:
2606:
2599:
2592:
2583:
2565:
2550:
2535:
2515:
2508:
2501:
2492:
2486:
2476:
2443:
2433:
2408:
2371:
2361:
2352:(39): 36989–92.
2336:
2326:
2301:
2272:
2262:
2252:
2235:(22): 14189–94.
2219:
2209:
2184:
2147:
2137:
2104:
2094:
2060:
2050:
2017:
2007:
1982:
1945:
1935:
1910:
1900:
1875:
1846:
1836:
1811:
1773:
1772:
1762:
1745:(12): 2398–408.
1730:
1724:
1723:
1713:
1689:
1683:
1682:
1645:
1639:
1638:
1628:
1604:
1598:
1597:
1587:
1563:
1557:
1556:
1546:
1529:(17): 3897–908.
1514:
1505:
1504:
1494:
1470:
1461:
1460:
1453:
1447:
1446:
1428:
1404:
1395:
1389:
1383:
1382:
1372:
1348:
1342:
1341:
1330:
1324:
1323:
1312:
1306:
1296:
1285:
1275:
1224:Two SNPs in the
1220:MAP3K3 in cancer
1125:
1124:
1096:
1089:
1072:
1060:
1051:
1027:
1023:RefSeq (protein)
1013:
1001:
992:
968:
944:
925:
899:
880:
854:
835:
804:
604:
590:
581:
574:
559:
499:
497:Top expressed in
492:
473:popliteal artery
437:
435:Top expressed in
430:
409:
392:
382:
369:
358:
343:
336:
330:
319:
307:
291:
281:
268:
257:
242:
235:
229:
218:
204:
188:
182:
133:
126:
103:
70:
64:
43:
42:
37:
25:
4781:
4780:
4776:
4775:
4774:
4772:
4771:
4770:
4751:
4750:
4749:
4737:
4729:
4727:
4722:
4634:Oxidoreductases
4620:
4596:Enzyme kinetics
4584:
4580:List of enzymes
4553:
4522:
4493:Catalytic triad
4471:
4466:
4436:
4423:
4371:
4349:
4273:
4256:
4239:
4222:
4193:
4053:
3953:
3924:P70-S6 Kinase 1
3894:
3785:
3747:
3725:
3691:
3667:
3628:
3594:
3300:
3271:
3247:
3228:
3149:
3125:
3086:
3042:
3025:
3001:
2995:Aurora C kinase
2990:Aurora B kinase
2985:Aurora A kinase
2965:
2946:
2912:
2883:
2816:
2782:
2638:
2624:
2610:
2580:
2575:
2572:
2566:
2557:
2551:
2542:
2536:
2522:
2519:
2489:
2459:(12): 1430–40.
2446:
2411:
2374:
2339:
2317:(21): 3307–18.
2304:
2275:
2222:
2200:(11): 1222–30.
2187:
2150:
2107:
2071:Genome Research
2063:
2033:(11): 1788–95.
2027:Genome Research
2020:
1998:(7): 5093–100.
1985:
1951:Nature Genetics
1948:
1926:(51): 36035–8.
1913:
1878:
1858:(1–2): 149–56.
1849:
1821:Genome Research
1814:
1785:
1781:
1779:Further reading
1776:
1732:
1731:
1727:
1691:
1690:
1686:
1663:10.1038/ncb1086
1647:
1646:
1642:
1619:(7): 5093–100.
1606:
1605:
1601:
1578:(11): 1222–30.
1565:
1564:
1560:
1516:
1515:
1508:
1485:(12): 4148–54.
1479:Cancer Research
1472:
1471:
1464:
1455:
1454:
1450:
1419:(11): 3102–14.
1406:
1405:
1398:
1390:
1386:
1350:
1349:
1345:
1332:
1331:
1327:
1314:
1313:
1309:
1297:
1288:
1276:
1267:
1263:
1222:
1217:
1182:
1165:
1134:View/Edit Mouse
1129:View/Edit Human
1092:
1085:
1082:Location (UCSC)
1068:
1047:
1043:
1039:
1035:
1009:
988:
984:
980:
976:
889:ENSG00000198909
782:
723:phosphorylation
686:
665:
641:kinase activity
631:protein binding
586:
555:
546:
541:
537:
533:
529:
525:
521:
517:
515:ascending aorta
513:
509:
495:
484:
479:
477:tibial arteries
475:
471:
467:
463:
459:
455:
451:
447:
433:
377:
364:
356:
346:
345:
344:
337:
317:
294:Gene location (
276:
263:
255:
245:
244:
243:
236:
214:
191:Gene location (
142:
129:
122:
79:
57:
23:
17:
12:
11:
5:
4779:
4777:
4769:
4768:
4763:
4753:
4752:
4748:
4747:
4724:
4723:
4721:
4720:
4707:
4694:
4681:
4668:
4655:
4642:
4628:
4626:
4622:
4621:
4619:
4618:
4613:
4608:
4603:
4598:
4592:
4590:
4586:
4585:
4583:
4582:
4577:
4572:
4567:
4561:
4559:
4558:Classification
4555:
4554:
4552:
4551:
4546:
4541:
4536:
4530:
4528:
4524:
4523:
4521:
4520:
4515:
4510:
4505:
4500:
4495:
4490:
4485:
4479:
4477:
4473:
4472:
4467:
4465:
4464:
4457:
4450:
4442:
4433:
4432:
4429:
4428:
4425:
4424:
4422:
4421:
4416:
4411:
4406:
4401:
4396:
4391:
4385:
4383:
4373:
4372:
4366:
4359:
4358:
4355:
4354:
4351:
4350:
4348:
4347:
4342:
4337:
4332:
4327:
4322:
4317:
4312:
4311:
4310:
4305:
4300:
4295:
4284:
4282:
4281:(EC 2.7.11.30)
4275:
4274:
4272:
4271:
4267:
4265:
4264:(EC 2.7.11.29)
4258:
4257:
4255:
4254:
4250:
4248:
4247:(EC 2.7.11.28)
4241:
4240:
4238:
4237:
4233:
4231:
4230:(EC 2.7.11.27)
4224:
4223:
4221:
4220:
4215:
4210:
4204:
4202:
4201:(EC 2.7.11.26)
4195:
4194:
4192:
4191:
4186:
4181:
4180:
4179:
4174:
4169:
4164:
4159:
4154:
4149:
4139:
4138:
4137:
4132:
4127:
4122:
4112:
4111:
4110:
4105:
4100:
4095:
4090:
4085:
4080:
4075:
4064:
4062:
4061:(EC 2.7.11.25)
4055:
4054:
4052:
4051:
4050:
4049:
4044:
4039:
4029:
4028:
4027:
4022:
4017:
4007:
4006:
4005:
4000:
3995:
3990:
3985:
3980:
3975:
3964:
3962:
3961:(EC 2.7.11.24)
3955:
3954:
3952:
3951:
3946:
3941:
3936:
3931:
3926:
3921:
3916:
3911:
3905:
3903:
3902:(EC 2.7.11.23)
3896:
3895:
3893:
3892:
3887:
3882:
3877:
3872:
3867:
3862:
3857:
3852:
3847:
3842:
3837:
3832:
3827:
3822:
3817:
3812:
3807:
3802:
3796:
3794:
3793:(EC 2.7.11.22)
3787:
3786:
3784:
3783:
3778:
3773:
3768:
3762:
3760:
3759:(EC 2.7.11.21)
3749:
3748:
3742:
3735:
3734:
3731:
3730:
3727:
3726:
3724:
3723:
3718:
3713:
3708:
3702:
3700:
3699:(EC 2.7.11.21)
3693:
3692:
3690:
3689:
3684:
3678:
3676:
3675:(EC 2.7.11.20)
3669:
3668:
3666:
3665:
3660:
3655:
3650:
3645:
3639:
3637:
3636:(EC 2.7.11.19)
3630:
3629:
3627:
3626:
3621:
3616:
3611:
3605:
3603:
3602:(EC 2.7.11.18)
3596:
3595:
3593:
3592:
3587:
3582:
3577:
3572:
3567:
3562:
3557:
3552:
3547:
3542:
3537:
3532:
3527:
3522:
3517:
3512:
3507:
3502:
3497:
3492:
3487:
3482:
3477:
3472:
3467:
3462:
3457:
3452:
3447:
3442:
3437:
3432:
3427:
3422:
3417:
3412:
3407:
3402:
3397:
3392:
3387:
3382:
3377:
3372:
3367:
3362:
3357:
3352:
3347:
3342:
3337:
3332:
3327:
3322:
3317:
3311:
3309:
3308:(EC 2.7.11.17)
3302:
3301:
3299:
3298:
3293:
3288:
3282:
3280:
3279:(EC 2.7.11.16)
3273:
3272:
3270:
3269:
3264:
3258:
3256:
3255:(EC 2.7.11.15)
3249:
3248:
3246:
3245:
3239:
3237:
3236:(EC 2.7.11.14)
3230:
3229:
3227:
3226:
3221:
3216:
3211:
3206:
3201:
3196:
3191:
3186:
3181:
3176:
3171:
3166:
3160:
3158:
3157:(EC 2.7.11.13)
3151:
3150:
3148:
3147:
3142:
3136:
3134:
3133:(EC 2.7.11.12)
3127:
3126:
3124:
3123:
3118:
3113:
3108:
3103:
3097:
3095:
3094:(EC 2.7.11.11)
3088:
3087:
3085:
3084:
3079:
3074:
3069:
3064:
3059:
3053:
3051:
3050:(EC 2.7.11.10)
3044:
3043:
3041:
3040:
3036:
3034:
3027:
3026:
3024:
3023:
3018:
3012:
3010:
3003:
3002:
3000:
2999:
2998:
2997:
2992:
2987:
2976:
2974:
2967:
2966:
2964:
2963:
2957:
2955:
2948:
2947:
2945:
2944:
2939:
2934:
2929:
2923:
2921:
2914:
2913:
2911:
2910:
2905:
2900:
2894:
2892:
2885:
2884:
2882:
2881:
2880:
2879:
2874:
2869:
2861:
2860:
2859:
2854:
2846:
2845:
2844:
2839:
2827:
2825:
2818:
2817:
2815:
2814:
2809:
2804:
2799:
2793:
2791:
2784:
2783:
2781:
2780:
2779:
2778:
2768:
2767:
2766:
2761:
2756:
2751:
2741:
2736:
2731:
2730:
2729:
2724:
2719:
2709:
2704:
2699:
2694:
2689:
2684:
2679:
2674:
2669:
2664:
2659:
2653:
2651:
2640:
2639:
2633:
2626:
2625:
2611:
2609:
2608:
2601:
2594:
2586:
2577:
2576:
2574:
2573:
2567:
2560:
2558:
2552:
2545:
2543:
2537:
2530:
2527:
2524:
2523:
2520:
2518:
2517:
2510:
2503:
2495:
2488:
2487:
2444:
2424:(9): 7576–83.
2409:
2389:10.1038/ni1014
2372:
2337:
2302:
2273:
2220:
2185:
2148:
2105:
2061:
2018:
1983:
1946:
1911:
1891:(6): 3476–83.
1876:
1847:
1827:(9): 791–806.
1812:
1794:(1–2): 171–4.
1782:
1780:
1777:
1775:
1774:
1739:Carcinogenesis
1725:
1704:(6): 3476–83.
1684:
1640:
1599:
1558:
1506:
1462:
1448:
1396:
1384:
1363:(5): 2668–74.
1343:
1325:
1307:
1286:
1264:
1262:
1259:
1221:
1218:
1216:
1215:
1209:
1203:
1197:
1190:
1181:
1178:
1164:
1161:
1141:
1140:
1137:
1136:
1131:
1121:
1120:
1114:
1113:
1110:
1109:
1107:
1105:
1098:
1097:
1090:
1083:
1079:
1078:
1075:
1074:
1064:
1063:
1057:
1054:
1053:
1031:
1030:
1024:
1020:
1019:
1016:
1015:
1005:
1004:
998:
995:
994:
972:
971:
965:
961:
960:
957:
956:
948:
947:
941:
938:
937:
929:
928:
922:
916:
915:
912:
911:
903:
902:
896:
893:
892:
884:
883:
877:
871:
870:
867:
866:
858:
857:
851:
848:
847:
839:
838:
832:
826:
825:
820:
815:
811:
810:
800:
799:
796:
795:
784:
783:
781:
780:
775:
770:
765:
760:
755:
750:
745:
740:
735:
730:
725:
720:
715:
710:
705:
700:
694:
692:
688:
687:
685:
684:
679:
673:
671:
667:
666:
664:
663:
658:
653:
648:
643:
638:
633:
628:
623:
617:
615:
611:
610:
600:
599:
596:
595:
592:
591:
583:
582:
571:
565:
564:
561:
560:
552:
551:
548:
547:
545:
544:
540:
536:
532:
528:
524:
520:
516:
512:
508:
504:
501:
500:
489:
486:
485:
483:
482:
478:
474:
470:
466:
462:
458:
457:gastric mucosa
454:
450:
446:
442:
439:
438:
426:
425:
417:
406:
400:
399:
396:RNA expression
388:
387:
384:
383:
375:
371:
370:
362:
359:
354:
348:
347:
338:
331:
325:
321:
320:
315:
309:
308:
300:
299:
287:
286:
283:
282:
274:
270:
269:
261:
258:
253:
247:
246:
237:
230:
224:
220:
219:
212:
206:
205:
197:
196:
184:
183:
140:
136:
135:
127:
119:
118:
114:
113:
110:
109:
106:
105:
75:
74:
66:
65:
54:
48:
47:
39:
38:
30:
29:
19:Main article:
15:
13:
10:
9:
6:
4:
3:
2:
4778:
4767:
4764:
4762:
4759:
4758:
4756:
4746:
4741:
4736:
4732:
4718:
4714:
4713:
4708:
4705:
4701:
4700:
4695:
4692:
4688:
4687:
4682:
4679:
4675:
4674:
4669:
4666:
4662:
4661:
4656:
4653:
4649:
4648:
4643:
4640:
4636:
4635:
4630:
4629:
4627:
4623:
4617:
4614:
4612:
4609:
4607:
4604:
4602:
4599:
4597:
4594:
4593:
4591:
4587:
4581:
4578:
4576:
4575:Enzyme family
4573:
4571:
4568:
4566:
4563:
4562:
4560:
4556:
4550:
4547:
4545:
4542:
4540:
4539:Cooperativity
4537:
4535:
4532:
4531:
4529:
4525:
4519:
4516:
4514:
4511:
4509:
4506:
4504:
4501:
4499:
4498:Oxyanion hole
4496:
4494:
4491:
4489:
4486:
4484:
4481:
4480:
4478:
4474:
4470:
4463:
4458:
4456:
4451:
4449:
4444:
4443:
4440:
4420:
4417:
4415:
4412:
4410:
4407:
4405:
4402:
4400:
4397:
4395:
4392:
4390:
4387:
4386:
4384:
4382:
4378:
4374:
4369:
4364:
4360:
4346:
4343:
4341:
4338:
4336:
4333:
4331:
4328:
4326:
4323:
4321:
4318:
4316:
4313:
4309:
4306:
4304:
4301:
4299:
4296:
4294:
4291:
4290:
4289:
4286:
4285:
4283:
4280:
4276:
4269:
4268:
4266:
4263:
4259:
4252:
4251:
4249:
4246:
4242:
4235:
4234:
4232:
4229:
4225:
4219:
4216:
4214:
4211:
4209:
4206:
4205:
4203:
4200:
4196:
4190:
4187:
4185:
4182:
4178:
4175:
4173:
4170:
4168:
4165:
4163:
4160:
4158:
4155:
4153:
4150:
4148:
4145:
4144:
4143:
4140:
4136:
4133:
4131:
4128:
4126:
4123:
4121:
4118:
4117:
4116:
4113:
4109:
4106:
4104:
4101:
4099:
4096:
4094:
4091:
4089:
4086:
4084:
4081:
4079:
4076:
4074:
4071:
4070:
4069:
4066:
4065:
4063:
4060:
4056:
4048:
4045:
4043:
4040:
4038:
4035:
4034:
4033:
4030:
4026:
4023:
4021:
4018:
4016:
4013:
4012:
4011:
4008:
4004:
4001:
3999:
3996:
3994:
3991:
3989:
3986:
3984:
3981:
3979:
3976:
3974:
3971:
3970:
3969:
3966:
3965:
3963:
3960:
3956:
3950:
3947:
3945:
3942:
3940:
3937:
3935:
3932:
3930:
3927:
3925:
3922:
3920:
3917:
3915:
3912:
3910:
3907:
3906:
3904:
3901:
3897:
3891:
3888:
3886:
3883:
3881:
3878:
3876:
3873:
3871:
3868:
3866:
3863:
3861:
3858:
3856:
3853:
3851:
3848:
3846:
3843:
3841:
3838:
3836:
3833:
3831:
3828:
3826:
3823:
3821:
3818:
3816:
3813:
3811:
3808:
3806:
3803:
3801:
3798:
3797:
3795:
3792:
3788:
3782:
3779:
3777:
3774:
3772:
3769:
3767:
3764:
3763:
3761:
3758:
3754:
3750:
3745:
3740:
3736:
3722:
3719:
3717:
3714:
3712:
3709:
3707:
3704:
3703:
3701:
3698:
3694:
3688:
3685:
3683:
3680:
3679:
3677:
3674:
3670:
3664:
3661:
3659:
3656:
3654:
3651:
3649:
3646:
3644:
3641:
3640:
3638:
3635:
3631:
3625:
3622:
3620:
3617:
3615:
3612:
3610:
3607:
3606:
3604:
3601:
3597:
3591:
3588:
3586:
3583:
3581:
3578:
3576:
3573:
3571:
3568:
3566:
3563:
3561:
3558:
3556:
3553:
3551:
3548:
3546:
3543:
3541:
3538:
3536:
3533:
3531:
3528:
3526:
3523:
3521:
3518:
3516:
3513:
3511:
3508:
3506:
3503:
3501:
3498:
3496:
3493:
3491:
3488:
3486:
3483:
3481:
3478:
3476:
3473:
3471:
3468:
3466:
3463:
3461:
3458:
3456:
3453:
3451:
3448:
3446:
3443:
3441:
3438:
3436:
3433:
3431:
3428:
3426:
3423:
3421:
3418:
3416:
3413:
3411:
3408:
3406:
3403:
3401:
3398:
3396:
3393:
3391:
3388:
3386:
3383:
3381:
3378:
3376:
3373:
3371:
3368:
3366:
3363:
3361:
3358:
3356:
3353:
3351:
3348:
3346:
3343:
3341:
3338:
3336:
3333:
3331:
3328:
3326:
3323:
3321:
3318:
3316:
3313:
3312:
3310:
3307:
3303:
3297:
3294:
3292:
3289:
3287:
3284:
3283:
3281:
3278:
3274:
3268:
3265:
3263:
3260:
3259:
3257:
3254:
3250:
3244:
3241:
3240:
3238:
3235:
3231:
3225:
3222:
3220:
3217:
3215:
3212:
3210:
3207:
3205:
3202:
3200:
3197:
3195:
3192:
3190:
3187:
3185:
3182:
3180:
3177:
3175:
3172:
3170:
3167:
3165:
3162:
3161:
3159:
3156:
3152:
3146:
3143:
3141:
3138:
3137:
3135:
3132:
3128:
3122:
3119:
3117:
3114:
3112:
3109:
3107:
3104:
3102:
3099:
3098:
3096:
3093:
3089:
3083:
3080:
3078:
3075:
3073:
3070:
3068:
3065:
3063:
3060:
3058:
3055:
3054:
3052:
3049:
3045:
3038:
3037:
3035:
3033:(EC 2.7.11.9)
3032:
3028:
3022:
3019:
3017:
3014:
3013:
3011:
3009:(EC 2.7.11.8)
3008:
3004:
2996:
2993:
2991:
2988:
2986:
2983:
2982:
2981:
2980:Aurora kinase
2978:
2977:
2975:
2973:(EC 2.7.11.7)
2972:
2968:
2962:
2959:
2958:
2956:
2954:(EC 2.7.11.6)
2953:
2949:
2943:
2940:
2938:
2935:
2933:
2930:
2928:
2925:
2924:
2922:
2920:(EC 2.7.11.5)
2919:
2915:
2909:
2906:
2904:
2901:
2899:
2896:
2895:
2893:
2891:(EC 2.7.11.4)
2890:
2886:
2878:
2875:
2873:
2870:
2868:
2865:
2864:
2862:
2858:
2855:
2853:
2850:
2849:
2847:
2843:
2840:
2838:
2835:
2834:
2832:
2829:
2828:
2826:
2824:(EC 2.7.11.3)
2823:
2819:
2813:
2810:
2808:
2805:
2803:
2800:
2798:
2795:
2794:
2792:
2790:(EC 2.7.11.2)
2789:
2785:
2777:
2774:
2773:
2772:
2769:
2765:
2762:
2760:
2757:
2755:
2752:
2750:
2747:
2746:
2745:
2744:EIF-2 kinases
2742:
2740:
2737:
2735:
2732:
2728:
2725:
2723:
2720:
2718:
2715:
2714:
2713:
2710:
2708:
2705:
2703:
2700:
2698:
2695:
2693:
2690:
2688:
2685:
2683:
2680:
2678:
2675:
2673:
2670:
2668:
2665:
2663:
2660:
2658:
2655:
2654:
2652:
2650:(EC 2.7.11.1)
2649:
2645:
2641:
2636:
2631:
2627:
2622:
2618:
2614:
2607:
2602:
2600:
2595:
2593:
2588:
2587:
2584:
2570:
2564:
2559:
2555:
2549:
2544:
2540:
2534:
2529:
2525:
2516:
2511:
2509:
2504:
2502:
2497:
2496:
2493:
2484:
2480:
2475:
2470:
2466:
2462:
2458:
2454:
2450:
2445:
2441:
2437:
2432:
2427:
2423:
2419:
2415:
2410:
2406:
2402:
2398:
2394:
2390:
2386:
2383:(1): 98–103.
2382:
2378:
2373:
2369:
2365:
2360:
2355:
2351:
2347:
2343:
2338:
2334:
2330:
2325:
2320:
2316:
2312:
2308:
2303:
2299:
2295:
2291:
2287:
2284:(1): 103–16.
2283:
2279:
2274:
2270:
2266:
2261:
2256:
2251:
2246:
2242:
2238:
2234:
2230:
2226:
2221:
2217:
2213:
2208:
2203:
2199:
2195:
2191:
2186:
2182:
2178:
2174:
2170:
2166:
2165:10.1038/89769
2162:
2158:
2154:
2149:
2145:
2141:
2136:
2131:
2127:
2123:
2120:(3): 287–92.
2119:
2115:
2111:
2106:
2102:
2098:
2093:
2088:
2084:
2080:
2077:(3): 422–35.
2076:
2072:
2068:
2062:
2058:
2054:
2049:
2044:
2040:
2036:
2032:
2028:
2024:
2019:
2015:
2011:
2006:
2001:
1997:
1993:
1989:
1984:
1980:
1976:
1972:
1968:
1964:
1963:10.1038/73550
1960:
1957:(3): 309–13.
1956:
1952:
1947:
1943:
1939:
1934:
1929:
1925:
1921:
1917:
1912:
1908:
1904:
1899:
1894:
1890:
1886:
1882:
1877:
1873:
1869:
1865:
1861:
1857:
1853:
1848:
1844:
1840:
1835:
1830:
1826:
1822:
1818:
1813:
1809:
1805:
1801:
1797:
1793:
1789:
1784:
1783:
1778:
1770:
1766:
1761:
1756:
1752:
1748:
1744:
1740:
1736:
1729:
1726:
1721:
1717:
1712:
1707:
1703:
1699:
1695:
1688:
1685:
1680:
1676:
1672:
1668:
1664:
1660:
1657:(2): 97–105.
1656:
1652:
1644:
1641:
1636:
1632:
1627:
1622:
1618:
1614:
1610:
1603:
1600:
1595:
1591:
1586:
1581:
1577:
1573:
1569:
1562:
1559:
1554:
1550:
1545:
1540:
1536:
1532:
1528:
1524:
1520:
1513:
1511:
1507:
1502:
1498:
1493:
1488:
1484:
1480:
1476:
1469:
1467:
1463:
1458:
1452:
1449:
1444:
1440:
1436:
1432:
1427:
1422:
1418:
1414:
1410:
1403:
1401:
1397:
1394:
1388:
1385:
1380:
1376:
1371:
1366:
1362:
1358:
1354:
1347:
1344:
1339:
1335:
1329:
1326:
1321:
1317:
1311:
1308:
1304:
1300:
1295:
1293:
1291:
1287:
1283:
1279:
1274:
1272:
1270:
1266:
1260:
1258:
1255:
1251:
1246:
1243:
1239:
1235:
1229:
1227:
1219:
1213:
1210:
1207:
1204:
1201:
1198:
1195:
1192:
1191:
1189:
1187:
1179:
1177:
1174:
1169:
1162:
1160:
1158:
1155:
1151:
1147:
1135:
1130:
1126:
1122:
1119:
1115:
1108:
1106:
1103:
1099:
1095:
1091:
1088:
1084:
1080:
1073:
1071:
1065:
1061:
1058:
1052:
1050:
1046:
1042:
1038:
1032:
1028:
1025:
1021:
1014:
1012:
1006:
1002:
999:
993:
991:
987:
983:
979:
973:
969:
966:
964:RefSeq (mRNA)
962:
955:
954:
949:
945:
942:
936:
935:
930:
926:
923:
921:
917:
910:
909:
904:
900:
897:
891:
890:
885:
881:
878:
876:
872:
865:
864:
859:
855:
852:
846:
845:
840:
836:
833:
831:
827:
824:
821:
819:
816:
812:
809:
805:
801:
794:
790:
785:
779:
776:
774:
771:
769:
766:
764:
761:
759:
756:
754:
751:
749:
746:
744:
741:
739:
736:
734:
731:
729:
726:
724:
721:
719:
716:
714:
711:
709:
706:
704:
701:
699:
696:
695:
693:
690:
689:
683:
680:
678:
675:
674:
672:
669:
668:
662:
659:
657:
654:
652:
649:
647:
644:
642:
639:
637:
634:
632:
629:
627:
624:
622:
619:
618:
616:
613:
612:
609:
608:Gene ontology
605:
601:
589:
584:
580:
575:
572:
570:
566:
558:
553:
542:
538:
534:
530:
526:
522:
518:
514:
510:
506:
505:
502:
498:
493:
490:
480:
476:
472:
468:
464:
461:apex of heart
460:
456:
452:
448:
444:
443:
440:
436:
431:
428:
427:
424:
422:
418:
416:
415:
411:
410:
407:
405:
401:
397:
393:
389:
381:
376:
372:
368:
363:
357:11|11 E1
353:
349:
342:
335:
329:
322:
314:
310:
306:
301:
297:
292:
288:
280:
275:
271:
267:
262:
252:
248:
241:
234:
228:
221:
217:
211:
207:
203:
198:
194:
189:
185:
181:
177:
173:
169:
165:
161:
157:
153:
149:
145:
137:
132:
125:
120:
115:
104:
102:
98:
94:
90:
86:
82:
76:
71:
68:
67:
63:
60:
53:
49:
44:
40:
36:
31:
26:
22:
4712:Translocases
4709:
4696:
4683:
4670:
4657:
4647:Transferases
4644:
4631:
4488:Binding site
4082:
3919:P70S6 kinase
2568:
2553:
2538:
2456:
2452:
2421:
2417:
2380:
2376:
2349:
2345:
2314:
2310:
2281:
2277:
2232:
2228:
2197:
2193:
2159:(7): 620–4.
2156:
2152:
2117:
2114:EMBO Reports
2113:
2074:
2070:
2030:
2026:
1995:
1991:
1954:
1950:
1923:
1919:
1888:
1884:
1855:
1851:
1824:
1820:
1791:
1787:
1742:
1738:
1728:
1701:
1697:
1687:
1654:
1650:
1643:
1616:
1612:
1602:
1575:
1571:
1561:
1526:
1522:
1482:
1478:
1451:
1416:
1412:
1387:
1360:
1356:
1346:
1337:
1328:
1319:
1310:
1247:
1230:
1225:
1223:
1183:
1180:Interactions
1170:
1166:
1153:
1145:
1144:
1067:
1049:NP_001350697
1037:NP_001317360
1034:
1008:
990:NM_001363768
986:NM_001330431
975:
951:
932:
906:
887:
861:
842:
822:
817:
753:MAPK cascade
519:aortic valve
419:
412:
378:106,046,272
365:105,975,439
139:External IDs
78:
4483:Active site
4370:(EC 2.7.12)
3757:Polo kinase
3697:Polo kinase
2521:PDB gallery
1168:expressed.
621:ATP binding
507:granulocyte
449:granulocyte
277:63,696,305
264:63,622,415
117:Identifiers
4755:Categories
4686:Isomerases
4660:Hydrolases
4527:Regulation
3048:IκB kinase
2623:2.7.11-12)
1305:, May 2017
1284:, May 2017
1261:References
1254:paclitaxel
465:right lung
423:(ortholog)
160:HomoloGene
4766:EC 2.7.11
4565:EC number
3174:PKC alpha
1242:apoptosis
1070:NP_036077
1045:NP_976226
1041:NP_002392
1011:NM_011947
982:NM_203351
978:NM_002401
808:Orthologs
682:cytoplasm
168:GeneCards
4589:Kinetics
4513:Cofactor
4476:Activity
3530:KIAA0999
3425:MAPKAPK5
3420:MAPKAPK3
3415:MAPKAPK2
2483:19008476
2440:14662759
2405:24806598
2397:14661019
2368:12912994
2333:12761501
2311:Oncogene
2298:12392720
2269:12391307
2216:12065326
2181:22382563
2173:11429546
2144:11256614
2101:11230166
2057:11076863
2014:11073940
1979:23203939
1971:10700190
1942:10593883
1769:23027623
1679:11683986
1671:14743216
1635:11073940
1594:12065326
1553:19517469
1501:15205325
1435:18855897
1301:–
1280:–
1188:with ,:
1186:interact
1163:Function
1118:Wikidata
787:Sources:
445:monocyte
4745:Biology
4699:Ligases
4469:Enzymes
4189:MAP3K14
4167:MAP3K11
4162:MAP3K10
4152:MAP3K13
4147:MAP3K12
3949:RPS6KC1
3944:RPS6KA1
3939:RPS6KA3
3934:RPS6KA2
3929:RPS6KB2
3914:RPS6KA4
3909:RPS6KA5
3560:Kalirin
3525:SNF1LK2
2764:EIF2AK4
2759:EIF2AK3
2613:Kinases
2474:2728220
2237:Bibcode
2135:1083732
1907:9452471
1872:9373149
1843:8889548
1808:8125298
1760:3510742
1720:9452471
1544:3061353
1379:9006902
1303:Ensembl
1282:Ensembl
920:UniProt
875:Ensembl
814:Species
793:QuickGO
677:cytosol
535:condyle
398:pattern
256:17q23.3
156:1346874
124:Aliases
4731:Portal
4673:Lyases
4419:MAP2K7
4414:MAP2K6
4409:MAP2K5
4404:MAP2K4
4399:MAP2K3
4394:MAP2K2
4389:MAP2K1
4340:ACVRL1
4335:ACVR2B
4330:ACVR2A
4325:ACVR1C
4320:ACVR1B
4303:BMPR1B
4298:BMPR1A
4172:MAP3K7
4157:MAP3K9
4108:MAP3K8
4103:MAP3K7
4098:MAP3K6
4093:MAP3K5
4088:MAP3K4
4083:MAP3K3
4078:MAP3K2
4073:MAP3K1
4047:MAPK14
4042:MAPK13
4037:MAPK11
4025:MAPK10
4003:MAPK15
3998:MAPK12
3890:CDC2L1
3865:CDC2L5
3540:SNF1LK
3365:CAMK2G
3360:CAMK2D
3355:CAMK2B
3350:CAMK2A
3340:CAMK1G
3335:CAMK1D
3330:CAMK1B
3325:CAMK1A
3179:PRKCB1
3116:PRKACA
3111:PRKACB
3106:PRKACG
3082:IKBKAP
2908:BCKDHB
2903:BCKDHA
2877:PRKAG3
2872:PRKAG2
2867:PRKAG1
2857:PRKAB2
2852:PRKAB1
2842:PRKAA2
2837:PRKAA1
2682:STK38L
2481:
2471:
2438:
2403:
2395:
2366:
2331:
2296:
2267:
2260:137859
2257:
2214:
2179:
2171:
2142:
2132:
2099:
2092:311072
2089:
2055:
2048:310948
2045:
2012:
1977:
1969:
1940:
1905:
1870:
1841:
1806:
1767:
1757:
1718:
1677:
1669:
1633:
1592:
1551:
1541:
1523:Cancer
1499:
1443:876964
1441:
1433:
1377:
1234:kinase
1226:MAP3K3
1208:, and
1206:MAP2K5
1196:, AKT.
1154:MAP3K3
1150:enzyme
1148:is an
1104:search
1102:PubMed
953:Q61084
934:Q99759
830:Entrez
569:BioGPS
481:spleen
172:MAP3K3
148:602539
131:MAP3K3
28:MAP3K3
4625:Types
4381:MAP2K
4315:ACVR1
4308:BMPR2
4293:BMPR1
4218:GSK-3
4059:MAP3K
4020:MAPK9
4015:MAPK8
3993:MAPK7
3988:MAPK6
3983:MAPK4
3978:MAPK3
3973:MAPK1
3885:PFTK1
3880:PCTK3
3875:PCTK2
3870:PCTK1
3860:CDK12
3855:CDK10
3830:CDKL5
3810:CDKL2
3687:STK19
3682:EEF2K
3663:PHKG2
3658:PHKG1
3648:PHKA2
3643:PHKA1
3624:MYLK4
3619:MYLK3
3614:MYLK2
3590:DCLK1
3585:Titin
3575:TRIB3
3570:TRIB2
3565:TRIB1
3555:TSSK2
3535:STK40
3520:PSKH1
3515:PRKD3
3510:PRKD2
3490:PHKG2
3485:PHKG1
3475:OBSCN
3470:NUAK2
3465:NUAK1
3460:MKNK2
3455:MKNK1
3445:MARK4
3440:MARK3
3435:MARK2
3430:MARK1
3410:STK11
3405:DAPK3
3400:DAPK2
3395:DAPK1
3390:CHEK2
3385:CHEK1
3370:CAMK4
3345:CAMK2
3320:CAMK1
3315:BRSK2
3209:PRKCQ
3204:PRKCI
3199:PRKCG
3194:PRKCH
3189:PRKCE
3184:PRKCD
3145:PRKG1
3077:IKBKG
3072:IKBKE
3021:STK10
3016:FASTK
2942:IDH3G
2937:IDH3B
2932:IDH3A
2898:BCKDK
2692:ROCK1
2677:STK38
2672:MAST2
2667:MAST1
2662:LATS2
2657:LATS1
2401:S2CID
2177:S2CID
1975:S2CID
1675:S2CID
1439:S2CID
1250:BRCA1
1212:YWHAE
1194:BRCA1
863:26406
823:Mouse
818:Human
789:Amigo
543:blood
527:fossa
453:blood
421:Mouse
414:Human
361:Start
296:Mouse
260:Start
193:Human
164:69110
4717:list
4710:EC7
4704:list
4697:EC6
4691:list
4684:EC5
4678:list
4671:EC4
4665:list
4658:EC3
4652:list
4645:EC2
4639:list
4632:EC1
4208:TPK1
4184:CDC7
4142:MLKs
4135:KSR2
4130:KSR1
4125:BRAF
4120:ARAF
4115:RAFs
3850:CDK9
3845:CDK8
3840:CDK7
3835:CDK6
3825:CDK5
3820:CDK4
3815:CDK3
3805:CDK2
3800:CDK1
3781:PLK4
3776:PLK3
3771:PLK2
3766:PLK1
3721:PLK4
3716:PLK3
3711:PLK2
3706:PLK1
3653:PHKB
3609:MYLK
3580:TRIO
3550:SPEG
3545:SNRK
3505:PKD1
3500:PIM2
3495:PIM1
3480:PASK
3450:MELK
3380:CASK
3375:MLCK
3296:GRK6
3291:GRK5
3286:GRK4
3224:PKN3
3219:PKN2
3121:PRKY
3067:TBK1
3062:IKK2
3057:CHUK
2961:STK4
2927:IDH2
2812:PDK4
2807:PDK3
2802:PDK2
2797:PDK1
2776:WEE1
2771:Wee1
2739:mTOR
2727:AKT3
2722:AKT2
2717:AKT1
2707:SGK3
2702:SGK2
2569:2pph
2554:2o2v
2539:2c60
2479:PMID
2436:PMID
2393:PMID
2364:PMID
2329:PMID
2294:PMID
2265:PMID
2212:PMID
2169:PMID
2140:PMID
2097:PMID
2053:PMID
2010:PMID
1967:PMID
1938:PMID
1903:PMID
1868:PMID
1852:Gene
1839:PMID
1804:PMID
1788:Gene
1765:PMID
1716:PMID
1667:PMID
1631:PMID
1590:PMID
1549:PMID
1497:PMID
1431:PMID
1375:PMID
1238:NFκB
1200:GAB1
1157:gene
844:4215
404:Bgee
352:Band
313:Chr.
251:Band
210:Chr.
144:OMIM
101:2O2V
97:4YL6
93:4Y5O
89:2PPH
85:2JRH
81:2C60
62:RCSB
59:PDBe
4213:TTK
4177:ZAK
2754:HRI
2749:PKR
2697:SGK
2687:CIT
2469:PMC
2461:doi
2457:103
2426:doi
2422:279
2385:doi
2354:doi
2350:278
2319:doi
2286:doi
2282:407
2255:PMC
2245:doi
2202:doi
2161:doi
2130:PMC
2122:doi
2087:PMC
2079:doi
2043:PMC
2035:doi
2000:doi
1996:276
1959:doi
1928:doi
1924:274
1893:doi
1889:273
1860:doi
1856:200
1829:doi
1796:doi
1792:138
1755:PMC
1747:doi
1706:doi
1702:273
1659:doi
1621:doi
1617:276
1580:doi
1539:PMC
1531:doi
1527:115
1487:doi
1421:doi
1417:237
1365:doi
1361:272
374:End
273:End
176:OMA
152:MGI
52:PDB
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2863:γ
2848:β
2833:α
2621:EC
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