244:
221:
118:
143:
509:
502:
495:
250:
149:
1667:
1383:
Oehrl W, Kardinal C, Ruf S, Adermann K, Groffen J, Feng GS, Blenis J, Tan TH, Feller SM (Oct 1998). "The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins".
1574:
Ma W, Xia C, Ling P, Qiu M, Luo Y, Tan TH, Liu M (Mar 2001). "Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes".
257:
156:
772:
753:
79:
1736:
1436:"Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase"
1712:
1331:"B cell adaptor containing src homology 2 domain (BASH) links B cell receptor signaling to the activation of hematopoietic progenitor kinase 1"
1731:
1209:
1191:
243:
992:
1285:
999:
220:
1178:
1157:
142:
117:
1174:
1153:
1535:"A novel src homology 3 domain-containing adaptor protein, HIP-55, that interacts with hematopoietic progenitor kinase 1"
59:
1122:
1078:
256:
155:
1705:
249:
148:
1066:
821:
67:
1065:. It is also known as HPK1 (Hematopoietic Progenitor Kinase 1). The protein has been shown to play a role in
802:
798:
1698:
131:
1229:"Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade"
46:
975:
946:
920:
891:
1600:
1409:
1303:
91:
1329:
Tsuji S, Okamoto M, Yamada K, Okamoto N, Goitsuka R, Arnold R, Kiefer F, Kitamura D (Aug 2001).
971:
950:
916:
895:
508:
501:
494:
1644:
1592:
1556:
1515:
1465:
1401:
1360:
1291:
1281:
1250:
39:
1682:
1492:
Ling P, Meyer CF, Redmond LP, Shui JW, Davis B, Rich RR, Hu MC, Wange RL, Tan TH (Jun 2001).
1634:
1623:"SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1"
1584:
1546:
1505:
1455:
1447:
1393:
1350:
1342:
1273:
1240:
336:
267:
211:
166:
87:
1315:
311:
1355:
1330:
1055:
1460:
1435:
687:
682:
677:
672:
667:
662:
657:
652:
647:
642:
637:
632:
627:
611:
606:
601:
585:
580:
575:
570:
565:
560:
555:
550:
1725:
1678:
1086:
537:
1604:
1413:
71:
1104:
329:
108:
95:
1214:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1196:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1494:"Involvement of hematopoietic progenitor kinase 1 in T cell receptor signaling"
412:
1277:
1092:
228:
125:
75:
1639:
1622:
1551:
1534:
1154:
ENSG00000104814 GRCh38: Ensembl release 89: ENSG00000282928, ENSG00000104814
717:
472:
350:
295:
282:
194:
181:
83:
1596:
1588:
1560:
1519:
1510:
1493:
1397:
1364:
1295:
1245:
1228:
1648:
1469:
1451:
1405:
1346:
1254:
1039:
1034:
1434:
Ling P, Yao Z, Meyer CF, Wang XS, Oehrl W, Feller SM, Tan TH (Feb 1999).
1023:
866:
847:
1621:
Anafi M, Kiefer F, Gish GD, Mbamalu G, Iscove NN, Pawson T (Oct 1997).
833:
784:
1533:
Ensenat D, Yao Z, Wang XS, Kori R, Zhou G, Lee SC, Tan TH (Nov 1999).
1007:
739:
1666:
1110:
702:
698:
1674:
1128:
1116:
1098:
1062:
517:
63:
50:, HPK1, mitogen-activated protein kinase kinase kinase kinase 1
1272:. Advances in Immunology. Vol. 129. pp. 277–314.
319:
1686:
1052:
Mitogen-activated protein kinase kinase kinase kinase 1
484:
1227:
Hu MC, Qiu WR, Wang X, Meyer CF, Tan TH (Dec 1996).
688:
cellular response to phorbol 13-acetate 12-myristate
964:
939:
909:
884:
1170:
1168:
1166:
1149:
1147:
1145:
1270:MAP4K Family Kinases in Immunity and Inflammation
678:stress-activated protein kinase signaling cascade
266:
165:
1487:
1485:
1483:
1481:
1479:
18:Protein-coding gene in the species Homo sapiens
1616:
1614:
1175:GRCm38: Ensembl release 89: ENSMUSG00000037337
1706:
1429:
1427:
1425:
1423:
1378:
1376:
1374:
8:
1713:
1699:
713:
533:
307:
206:
103:
1638:
1550:
1509:
1459:
1354:
1244:
566:protein serine/threonine kinase activity
561:MAP kinase kinase kinase kinase activity
1141:
1311:
1301:
20:
683:activation of protein kinase activity
271:
232:
227:
170:
129:
124:
7:
1663:
1661:
1685:. You can help Knowledge (XXG) by
1268:Chuang HC, Wang X, Tan TH (2016).
961:
936:
906:
881:
857:
838:
812:
789:
763:
744:
612:intracellular anatomical structure
489:
407:
345:
324:
14:
1058:that in humans is encoded by the
648:intracellular signal transduction
1665:
663:regulation of mitotic cell cycle
507:
500:
493:
255:
248:
242:
219:
154:
147:
141:
116:
668:regulation of apoptotic process
653:peptidyl-serine phosphorylation
1737:Human chromosome 19 gene stubs
518:More reference expression data
473:More reference expression data
1:
643:cell population proliferation
240:
139:
1732:Genes on human chromosome 19
1123:Linker of activated T cells
628:protein autophosphorylation
1753:
1660:
1278:10.1016/bs.ai.2015.09.006
1210:"Mouse PubMed Reference:"
1192:"Human PubMed Reference:"
1077:MAP4K1 has been shown to
1038:
1033:
1029:
1022:
1006:
987:
968:
943:
932:
913:
888:
877:
864:
860:
845:
841:
832:
819:
815:
796:
792:
783:
770:
766:
751:
747:
738:
723:
716:
712:
696:
536:
532:
515:
492:
483:
470:
419:
410:
357:
348:
318:
310:
306:
289:
276:
239:
218:
209:
205:
188:
175:
138:
115:
106:
102:
57:
54:
44:
37:
32:
28:
23:
1640:10.1074/jbc.272.44.27804
1552:10.1074/jbc.274.48.33945
993:Chr 19: 38.59 – 38.62 Mb
633:protein phosphorylation
556:protein kinase activity
1589:10.1038/sj.onc.1204224
1511:10.1074/jbc.M101485200
1398:10.1038/sj.onc.1202108
1246:10.1101/gad.10.18.2251
1000:Chr 7: 28.68 – 28.7 Mb
423:mesenteric lymph nodes
1452:10.1128/MCB.19.2.1359
1347:10.1084/jem.194.4.529
132:Chromosome 19 (human)
551:transferase activity
234:Chromosome 7 (mouse)
673:signal transduction
1673:This article on a
822:ENSMUSG00000037337
638:response to stress
621:Biological process
595:Cellular component
571:nucleotide binding
544:Molecular function
96:MAP4K1 - orthologs
1694:
1693:
1049:
1048:
1045:
1044:
1018:
1017:
983:
982:
958:
957:
928:
927:
903:
902:
873:
872:
854:
853:
828:
827:
809:
808:
779:
778:
760:
759:
708:
707:
528:
527:
524:
523:
479:
478:
466:
465:
404:
403:
377:bone marrow cells
302:
301:
201:
200:
1744:
1715:
1708:
1701:
1669:
1662:
1653:
1652:
1642:
1633:(44): 27804–11.
1618:
1609:
1608:
1571:
1565:
1564:
1554:
1545:(48): 33945–50.
1530:
1524:
1523:
1513:
1504:(22): 18908–14.
1489:
1474:
1473:
1463:
1431:
1418:
1417:
1392:(15): 1893–901.
1380:
1369:
1368:
1358:
1326:
1320:
1319:
1313:
1309:
1307:
1299:
1265:
1259:
1258:
1248:
1224:
1218:
1217:
1206:
1200:
1199:
1188:
1182:
1172:
1161:
1151:
1031:
1030:
1002:
995:
978:
962:
953:
937:
933:RefSeq (protein)
923:
907:
898:
882:
858:
839:
813:
790:
764:
745:
714:
534:
520:
511:
504:
497:
490:
475:
415:
413:Top expressed in
408:
353:
351:Top expressed in
346:
325:
308:
298:
285:
274:
259:
252:
246:
235:
223:
207:
197:
184:
173:
158:
151:
145:
134:
120:
104:
98:
49:
42:
21:
1752:
1751:
1747:
1746:
1745:
1743:
1742:
1741:
1722:
1721:
1720:
1719:
1658:
1656:
1620:
1619:
1612:
1583:(14): 1703–14.
1573:
1572:
1568:
1532:
1531:
1527:
1491:
1490:
1477:
1440:Mol. Cell. Biol
1433:
1432:
1421:
1382:
1381:
1372:
1328:
1327:
1323:
1310:
1300:
1288:
1267:
1266:
1262:
1239:(18): 2251–64.
1226:
1225:
1221:
1208:
1207:
1203:
1190:
1189:
1185:
1173:
1164:
1152:
1143:
1139:
1134:
1075:
1040:View/Edit Mouse
1035:View/Edit Human
998:
991:
988:Location (UCSC)
974:
970:
949:
945:
919:
915:
894:
890:
803:ENSG00000104814
801:
799:ENSG00000282928
692:
658:phosphorylation
616:
590:
586:kinase activity
576:protein binding
516:
506:
505:
499:
498:
471:
462:
457:
453:
449:
445:
441:
437:
433:
429:
425:
411:
400:
395:
391:
387:
383:
379:
375:
371:
367:
363:
349:
293:
280:
272:
262:
261:
260:
253:
233:
210:Gene location (
192:
179:
171:
161:
160:
159:
152:
130:
107:Gene location (
58:
45:
38:
19:
12:
11:
5:
1750:
1748:
1740:
1739:
1734:
1724:
1723:
1718:
1717:
1710:
1703:
1695:
1692:
1691:
1670:
1655:
1654:
1610:
1566:
1525:
1475:
1446:(2): 1359–68.
1419:
1370:
1321:
1312:|journal=
1286:
1260:
1219:
1201:
1183:
1162:
1140:
1138:
1135:
1133:
1132:
1126:
1120:
1114:
1108:
1102:
1096:
1090:
1083:
1074:
1071:
1056:protein kinase
1047:
1046:
1043:
1042:
1037:
1027:
1026:
1020:
1019:
1016:
1015:
1013:
1011:
1004:
1003:
996:
989:
985:
984:
981:
980:
966:
965:
959:
956:
955:
941:
940:
934:
930:
929:
926:
925:
911:
910:
904:
901:
900:
886:
885:
879:
875:
874:
871:
870:
862:
861:
855:
852:
851:
843:
842:
836:
830:
829:
826:
825:
817:
816:
810:
807:
806:
794:
793:
787:
781:
780:
777:
776:
768:
767:
761:
758:
757:
749:
748:
742:
736:
735:
730:
725:
721:
720:
710:
709:
706:
705:
694:
693:
691:
690:
685:
680:
675:
670:
665:
660:
655:
650:
645:
640:
635:
630:
624:
622:
618:
617:
615:
614:
609:
604:
598:
596:
592:
591:
589:
588:
583:
578:
573:
568:
563:
558:
553:
547:
545:
541:
540:
530:
529:
526:
525:
522:
521:
513:
512:
487:
481:
480:
477:
476:
468:
467:
464:
463:
461:
460:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
417:
416:
405:
402:
401:
399:
398:
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
355:
354:
342:
341:
333:
322:
316:
315:
312:RNA expression
304:
303:
300:
299:
291:
287:
286:
278:
275:
270:
264:
263:
254:
247:
241:
237:
236:
231:
225:
224:
216:
215:
203:
202:
199:
198:
190:
186:
185:
177:
174:
169:
163:
162:
153:
146:
140:
136:
135:
128:
122:
121:
113:
112:
100:
99:
56:
52:
51:
43:
35:
34:
30:
29:
26:
25:
17:
13:
10:
9:
6:
4:
3:
2:
1749:
1738:
1735:
1733:
1730:
1729:
1727:
1716:
1711:
1709:
1704:
1702:
1697:
1696:
1690:
1688:
1684:
1680:
1679:chromosome 19
1676:
1671:
1668:
1664:
1659:
1650:
1646:
1641:
1636:
1632:
1628:
1627:J. Biol. Chem
1624:
1617:
1615:
1611:
1606:
1602:
1598:
1594:
1590:
1586:
1582:
1578:
1570:
1567:
1562:
1558:
1553:
1548:
1544:
1540:
1539:J. Biol. Chem
1536:
1529:
1526:
1521:
1517:
1512:
1507:
1503:
1499:
1498:J. Biol. Chem
1495:
1488:
1486:
1484:
1482:
1480:
1476:
1471:
1467:
1462:
1457:
1453:
1449:
1445:
1441:
1437:
1430:
1428:
1426:
1424:
1420:
1415:
1411:
1407:
1403:
1399:
1395:
1391:
1387:
1379:
1377:
1375:
1371:
1366:
1362:
1357:
1352:
1348:
1344:
1341:(4): 529–39.
1340:
1336:
1332:
1325:
1322:
1317:
1305:
1297:
1293:
1289:
1287:9780128047996
1283:
1279:
1275:
1271:
1264:
1261:
1256:
1252:
1247:
1242:
1238:
1234:
1230:
1223:
1220:
1215:
1211:
1205:
1202:
1197:
1193:
1187:
1184:
1180:
1176:
1171:
1169:
1167:
1163:
1159:
1155:
1150:
1148:
1146:
1142:
1136:
1130:
1127:
1124:
1121:
1118:
1115:
1112:
1109:
1106:
1103:
1100:
1097:
1094:
1091:
1088:
1087:B-cell linker
1085:
1084:
1082:
1080:
1072:
1070:
1068:
1064:
1061:
1057:
1053:
1041:
1036:
1032:
1028:
1025:
1021:
1014:
1012:
1009:
1005:
1001:
997:
994:
990:
986:
979:
977:
973:
967:
963:
960:
954:
952:
948:
942:
938:
935:
931:
924:
922:
918:
912:
908:
905:
899:
897:
893:
887:
883:
880:
878:RefSeq (mRNA)
876:
869:
868:
863:
859:
856:
850:
849:
844:
840:
837:
835:
831:
824:
823:
818:
814:
811:
805:
804:
800:
795:
791:
788:
786:
782:
775:
774:
769:
765:
762:
756:
755:
750:
746:
743:
741:
737:
734:
731:
729:
726:
722:
719:
715:
711:
704:
700:
695:
689:
686:
684:
681:
679:
676:
674:
671:
669:
666:
664:
661:
659:
656:
654:
651:
649:
646:
644:
641:
639:
636:
634:
631:
629:
626:
625:
623:
620:
619:
613:
610:
608:
605:
603:
600:
599:
597:
594:
593:
587:
584:
582:
579:
577:
574:
572:
569:
567:
564:
562:
559:
557:
554:
552:
549:
548:
546:
543:
542:
539:
538:Gene ontology
535:
531:
519:
514:
510:
503:
496:
491:
488:
486:
482:
474:
469:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
421:
418:
414:
409:
406:
396:
392:
388:
384:
380:
376:
372:
368:
364:
360:
359:
356:
352:
347:
344:
343:
340:
338:
334:
332:
331:
327:
326:
323:
321:
317:
313:
309:
305:
297:
292:
288:
284:
279:
269:
265:
258:
251:
245:
238:
230:
226:
222:
217:
213:
208:
204:
196:
191:
187:
183:
178:
168:
164:
157:
150:
144:
137:
133:
127:
123:
119:
114:
110:
105:
101:
97:
93:
89:
85:
81:
77:
73:
69:
65:
61:
53:
48:
41:
36:
31:
27:
22:
16:
1687:expanding it
1672:
1657:
1630:
1626:
1580:
1576:
1569:
1542:
1538:
1528:
1501:
1497:
1443:
1439:
1389:
1385:
1338:
1334:
1324:
1269:
1263:
1236:
1232:
1222:
1213:
1204:
1195:
1186:
1105:Drebrin-like
1076:
1073:Interactions
1069:activation.
1059:
1051:
1050:
976:NP_001341983
969:
947:NP_001036065
944:
921:NM_001355054
914:
892:NM_001042600
889:
865:
846:
820:
797:
771:
752:
732:
727:
335:
328:
55:External IDs
15:
1335:J. Exp. Med
581:ATP binding
451:granulocyte
443:ankle joint
397:sural nerve
361:granulocyte
294:28,702,704
281:28,681,475
273:7|7 B1
193:38,618,882
180:38,587,641
33:Identifiers
1726:Categories
1181:, May 2017
1160:, May 2017
1137:References
365:lymph node
339:(ortholog)
76:HomoloGene
1677:on human
1314:ignored (
1304:cite book
1233:Genes Dev
972:NP_032305
951:NP_009112
917:NM_008279
896:NM_007181
718:Orthologs
602:cytoplasm
435:spermatid
84:GeneCards
1605:25646725
1597:11313918
1577:Oncogene
1561:10567356
1520:11279207
1414:19885101
1386:Oncogene
1365:11514608
1296:26791862
1177:–
1156:–
1079:interact
1024:Wikidata
697:Sources:
607:membrane
393:testicle
385:monocyte
373:appendix
1649:9346925
1470:9891069
1406:9788432
1356:2193495
1255:8824585
1179:Ensembl
1158:Ensembl
834:UniProt
785:Ensembl
724:Species
703:QuickGO
314:pattern
172:19q13.2
72:1346882
40:Aliases
1647:
1603:
1595:
1559:
1518:
1468:
1461:116064
1458:
1412:
1404:
1363:
1353:
1294:
1284:
1253:
1125:, and
1081:with:
1060:MAP4K1
1010:search
1008:PubMed
867:P70218
848:Q92918
740:Entrez
485:BioGPS
459:embryo
455:embryo
447:morula
431:thymus
427:spleen
389:tonsil
369:spleen
88:MAP4K1
64:601983
47:MAP4K1
24:MAP4K1
1681:is a
1601:S2CID
1410:S2CID
1111:GRAP2
1054:is a
773:26411
754:11184
733:Mouse
728:Human
699:Amigo
439:blood
381:blood
337:Mouse
330:Human
277:Start
212:Mouse
176:Start
109:Human
1683:stub
1675:gene
1645:PMID
1593:PMID
1557:PMID
1516:PMID
1466:PMID
1402:PMID
1361:PMID
1316:help
1292:PMID
1282:ISBN
1251:PMID
1129:NCK1
1117:Grb2
1099:CRKL
1063:gene
320:Bgee
268:Band
229:Chr.
167:Band
126:Chr.
80:5199
60:OMIM
1635:doi
1631:272
1585:doi
1547:doi
1543:274
1506:doi
1502:276
1456:PMC
1448:doi
1394:doi
1351:PMC
1343:doi
1339:194
1274:doi
1241:doi
1093:CRK
1067:JNK
290:End
189:End
92:OMA
68:MGI
1728::
1643:.
1629:.
1625:.
1613:^
1599:.
1591:.
1581:20
1579:.
1555:.
1541:.
1537:.
1514:.
1500:.
1496:.
1478:^
1464:.
1454:.
1444:19
1442:.
1438:.
1422:^
1408:.
1400:.
1390:17
1388:.
1373:^
1359:.
1349:.
1337:.
1333:.
1308::
1306:}}
1302:{{
1290:.
1280:.
1249:.
1237:10
1235:.
1231:.
1212:.
1194:.
1165:^
1144:^
701:/
296:bp
283:bp
195:bp
182:bp
90:;
86::
82:;
78::
74:;
70::
66:;
62::
1714:e
1707:t
1700:v
1689:.
1651:.
1637::
1607:.
1587::
1563:.
1549::
1522:.
1508::
1472:.
1450::
1416:.
1396::
1367:.
1345::
1318:)
1298:.
1276::
1257:.
1243::
1216:.
1198:.
1131:.
1119:,
1113:,
1107:,
1101:,
1095:,
1089:,
214:)
111:)
94::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
