420:
397:
3635:
294:
319:
3605:
3650:
3665:
3530:
3515:
3590:
678:
671:
3455:
3500:
3485:
3470:
3440:
3575:
3620:
426:
325:
31:
3560:
3545:
5842:
57:
3634:
3705:
3990:
3604:
2348:
Cano E, Hazzalin CA, Kardalinou E, Buckle RS, Mahadevan LC (November 1995). "Neither ERK nor JNK/SAPK MAP kinase subtypes are essential for histone H3/HMG-14 phosphorylation or c-fos and c-jun induction".
3649:
1805:
DĂ©rijard B, Hibi M, Wu IH, Barrett T, Su B, Deng T, Karin M, Davis RJ (April 1994). "JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain".
3664:
3529:
3514:
3698:
3589:
3691:
3898:
433:
332:
3454:
3499:
3484:
3469:
4446:
5285:
3749:
1938:"Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine"
5394:
4132:
4019:
3384:
2476:"Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1"
1096:
255:
4407:
1077:
3439:
5380:
4845:
3736:
3718:
1541:
family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as
5482:
5363:
2599:"The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)"
5069:
3938:
3574:
3221:
Mao C, Ray-Gallet D, Tavitian A, Moreau-Gachelin F (February 1996). "Differential phosphorylations of Spi-B and Spi-1 transcription factors".
2133:"Interaction between c-Rel and the mitogen-activated protein kinase kinase kinase 1 signaling cascade in mediating kappaB enhancer activation"
5862:
5133:
4108:
3619:
3419:
2761:"Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation"
1784:
1766:
5389:
2307:
Tada K, Okazaki T, Sakon S, Kobarai T, Kurosawa K, Yamaoka S, Hashimoto H, Mak TW, Yagita H, Okumura K, Yeh WC, Nakano H (September 2001).
419:
3923:
5446:
5121:
3265:
1452:
3035:"JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway"
2558:"Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action"
1459:
396:
5561:
4378:
4368:
4053:
2517:"Glutathione S-transferase P1-1 (GSTP1-1) inhibits c-Jun N-terminal kinase (JNK1) signaling through interaction with the C terminus"
1602:
5060:
1898:
1534:
5329:
5001:
4363:
4354:
1753:
1732:
3033:
Ito M, Yoshioka K, Akechi M, Yamashita S, Takamatsu N, Sugiyama K, Hibi M, Nakabeppu Y, Shiba T, Yamamoto KI (November 1999).
3643:: Crystal structure of human JNK3 complexed with N-{3-cyano-6--4,5,6,7-tetrahydrothienopyridin-2-yl}-1-naphthalenecarboxamide
318:
293:
5717:
1749:
54:
4744:
4241:
4232:
3889:
3835:
3613:: Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide C-jun NH2-terminal Kinase Inhibitors
1573:-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in
5832:
2309:"Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death"
1728:
3932:
235:
1594:
1558:
432:
331:
3683:
4956:
4774:
4270:
3658:: Crystal structure of human JNK3 complexed with N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide
1549:, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific
5702:
3559:
3544:
425:
324:
5818:
5805:
5792:
5779:
5766:
5753:
5740:
4946:
4941:
4936:
4926:
4921:
4916:
4906:
4701:
4476:
4072:
3412:
3320:"Wiring the cell signaling circuitry by the NF-kappa B and JNK1 crosstalk and its applications in human diseases"
226:, Mapk8, AI849689, JNK, JNK1, Prkm8, SAPK1, JNK-46, JNK1A2, JNK21B1/2, SAPK1c, mitogen-activated protein kinase 8
5712:
1912:
5666:
5609:
5169:
5160:
5111:
3877:
3722:
1546:
1538:
1141:
243:
3673:: Crystal structure of JNK3 bound to N-benzyl-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide
2994:"Phosphorylation of Pax2 by the c-Jun N-terminal kinase and enhanced Pax2-dependent transcription activation"
5614:
5469:
4892:
1122:
887:
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
1585:
have been reported. MAPK8 contains multiple amino acid sites that are phosphorylated and ubiquitinated.
5635:
5554:
4168:
307:
5707:
3371:
4735:
3405:
3174:"A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria"
2821:
2708:
2651:
2225:
Nishitoh H, Saitoh M, Mochida Y, Takeda K, Nakano H, Rothe M, Miyazono K, Ichijo H (September 1998).
2082:
1578:
1550:
3538:: Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125
3523:: Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125
2697:"Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change"
222:
5671:
3084:"Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3"
1431:
1427:
1423:
1394:
1390:
1386:
1382:
1378:
1374:
1370:
1366:
1362:
1358:
1348:
1344:
1340:
1336:
1332:
1308:
1304:
1300:
1279:
1275:
1271:
1267:
1263:
1259:
1255:
1251:
1247:
1243:
1239:
1235:
1231:
1209:
1205:
5243:
5867:
5604:
5346:
5300:
3349:
3306:
2974:
2810:"JLP: A scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors"
2677:
1831:
1542:
267:
1979:"c-Jun NH2-terminal kinases target the ubiquitination of their associated transcription factors"
1435:
1402:
1398:
1312:
1221:
1217:
1213:
4606:
4315:
3341:
3298:
3261:
3230:
3203:
3154:
3113:
3064:
3015:
2966:
2931:
2890:
2849:
2790:
2736:
2669:
2620:
2579:
2538:
2497:
2456:
2415:
2366:
2330:
2289:
2248:
2207:
2154:
2110:
2044:
2000:
1959:
1880:
1823:
677:
670:
215:
47:
3133:"Regulation of c-Myc through phosphorylation at Ser-62 and Ser-71 by c-Jun N-terminal kinase"
5650:
5645:
5619:
5547:
5199:
4441:
4431:
4426:
4344:
4335:
4265:
4256:
4202:
4193:
3850:
3331:
3288:
3193:
3185:
3144:
3103:
3095:
3054:
3046:
3005:
2958:
2921:
2880:
2839:
2829:
2780:
2772:
2726:
2716:
2659:
2610:
2569:
2528:
2487:
2446:
2405:
2397:
2358:
2320:
2279:
2238:
2197:
2189:
2144:
2100:
2090:
2071:"Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase"
2034:
1990:
1949:
1870:
1862:
1815:
512:
443:
387:
342:
263:
5697:
5681:
5594:
5025:
4096:
4091:
4086:
3375:
1849:
Gupta S, Barrett T, Whitmarsh AJ, Cavanagh J, Sluss HK, DĂ©rijard B, Davis RJ (July 1996).
1569:
is also involved in UV radiation-induced apoptosis, which is thought to be related to the
1554:
487:
3598:: Selective Aminopyridine-Based C-Jun N-terminal Kinase inhibitors with cellular activity
2386:"A direct interaction between JNK1 and CrkII is critical for Rac1-induced JNK activation"
2023:"Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2"
2825:
2712:
2655:
2640:"Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch"
2086:
5846:
5735:
5676:
3198:
3173:
2910:"MEKK1 binds directly to the c-Jun N-terminal kinases/stress-activated protein kinases"
2731:
2696:
2435:"Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5"
2173:
1936:
Raingeaud J, Gupta S, Rogers JS, Dickens M, Han J, Ulevitch RJ, Davis RJ (March 1995).
1866:
30:
3293:
3276:
2869:"Akt (protein kinase B) negatively regulates SEK1 by means of protein phosphorylation"
2844:
2809:
2410:
2385:
2243:
2226:
2202:
2177:
1875:
1850:
1011:
1006:
1001:
996:
991:
986:
981:
976:
971:
966:
961:
956:
951:
946:
941:
936:
931:
926:
921:
916:
911:
906:
901:
896:
891:
886:
881:
876:
871:
866:
861:
856:
851:
846:
841:
825:
820:
815:
810:
805:
800:
795:
790:
774:
769:
764:
759:
754:
749:
744:
739:
734:
729:
724:
719:
5856:
5640:
5599:
4149:
4081:
3388:
3108:
3083:
3059:
3034:
2785:
2760:
2105:
2070:
1819:
706:
3353:
3099:
2978:
2776:
2681:
247:
5589:
5020:
3845:
3131:
Noguchi K, Kitanaka C, Yamana H, Kokubu A, Mochizuki T, Kuchino Y (November 1999).
2992:
Cai Y, Lechner MS, Nihalani D, Prindle MJ, Holzman LB, Dressler GR (January 2002).
1835:
1570:
505:
284:
3310:
3252:
Lin, A (2006). "The JNK Signaling
Pathway (Molecular Biology Intelligence Unit)".
2962:
1851:"Selective interaction of JNK protein kinase isoforms with transcription factors"
271:
5813:
5748:
5584:
5226:
4858:
4798:
4681:
4601:
4325:
1789:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1771:
National Center for
Biotechnology Information, U.S. National Library of Medicine
5841:
2701:
Proceedings of the
National Academy of Sciences of the United States of America
2401:
588:
5314:
3788:
2556:
Aguirre V, Werner ED, Giraud J, Lee YH, Shoelson SE, White MF (January 2002).
1614:
404:
301:
251:
3463:: Crystal structure of JNK3 in complex with an imidazole-pyrimidine inhibitor
3149:
3132:
2926:
2909:
2638:
Gao M, Labuda T, Xia Y, Gallagher E, Fang D, Liu YC, Karin M (October 2004).
2451:
2434:
1995:
1978:
5787:
5761:
4275:
3172:
Wiltshire C, Matsushita M, Tsukada S, Gillespie DA, May GH (November 2002).
2721:
2664:
2639:
2615:
2598:
2362:
2149:
2132:
2095:
1954:
1937:
1562:
1041:
648:
526:
471:
458:
370:
357:
259:
3345:
3336:
3319:
3302:
3207:
3158:
3117:
3068:
3050:
3019:
3010:
2993:
2894:
2885:
2868:
2867:
Park HS, Kim MS, Huh SH, Park J, Chung J, Kang SS, Choi EJ (January 2002).
2853:
2834:
2794:
2740:
2673:
2624:
2583:
2574:
2557:
2542:
2533:
2516:
2501:
2492:
2475:
2460:
2419:
2334:
2325:
2308:
2293:
2284:
2267:
2211:
2193:
2048:
2039:
2022:
3234:
2970:
2935:
2370:
2252:
2158:
2114:
2004:
1963:
1884:
1827:
1499:
1494:
4631:
4526:
4521:
4516:
3508:: The structure of JNK3 in complex with a dihydroanthrapyrazole inhibitor
3493:: The crystal structure of JNK3 in complex with a phenantroline inhibitor
3478:: The structure of JNK3 in complex with an imidazole-pyrimidine inhibitor
1679:
1673:
1483:
1186:
1167:
5290:
5268:
5263:
5253:
5248:
5050:
5045:
5040:
5035:
5030:
5015:
5010:
4661:
4626:
3865:
3860:
3855:
3189:
2069:
Tournier C, Whitmarsh AJ, Cavanagh J, Barrett T, Davis RJ (July 1997).
1977:
Fuchs SY, Xie B, Adler V, Fried VA, Davis RJ, Ronai Z (December 1997).
1582:
1153:
1108:
2808:
Lee CM, Onésime D, Reddy CD, Dhanasekaran N, Reddy EP (October 2002).
192:
188:
184:
180:
176:
172:
168:
164:
160:
156:
152:
148:
144:
140:
136:
132:
128:
124:
120:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
76:
5800:
5570:
5520:
5515:
5510:
5505:
5500:
5495:
5490:
5441:
5436:
5431:
5426:
5421:
5404:
5399:
5273:
5258:
5209:
5204:
5189:
5184:
5179:
5174:
5148:
5143:
5138:
5126:
5104:
5099:
4991:
4966:
4641:
4466:
4461:
4456:
4451:
4436:
4280:
4217:
4212:
4207:
4183:
4009:
4004:
3978:
3973:
3968:
3958:
3953:
3943:
3783:
3714:
1697:
1667:
1662:
1656:
1650:
1620:
1574:
1566:
1515:
1467:
1063:
5774:
5416:
5409:
5319:
5216:
5094:
5089:
5084:
5079:
5074:
4986:
4981:
4976:
4971:
4961:
4931:
4911:
4788:
4783:
4764:
4759:
4749:
4725:
4720:
4715:
4691:
4686:
4676:
4671:
4666:
4656:
4636:
4621:
4616:
4611:
4591:
4586:
4576:
4571:
4566:
4561:
4556:
4546:
4541:
4536:
4531:
4511:
4506:
4501:
4496:
4491:
4486:
4471:
4421:
4416:
4310:
4305:
4300:
4295:
4290:
4285:
4246:
4178:
4173:
4122:
4117:
4043:
4038:
4033:
3999:
3991:
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase
3793:
3778:
3773:
3768:
3763:
3758:
1632:
1626:
1608:
2178:"Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling"
1026:
1022:
5309:
5236:
5231:
5221:
5194:
4951:
4901:
4882:
4877:
4872:
4867:
4822:
4817:
4812:
4807:
4754:
4710:
4651:
4646:
4596:
4581:
4551:
4481:
4397:
4392:
4387:
4320:
4222:
4163:
4158:
4062:
4028:
3913:
3908:
3903:
3872:
3840:
3828:
3823:
3818:
3808:
3803:
1703:
1644:
1638:
1522:
239:
5543:
5467:
4843:
3734:
3687:
3401:
2597:
Aguirre V, Uchida T, Yenush L, Davis R, White MF (March 2000).
686:
5278:
3813:
3798:
3448:: THE C-JUN N-TERMINAL KINASE (JNK3S) COMPLEXED WITH MGAMP-PNP
3397:
1691:
1685:
1557:
in response to cell stimuli. The activation of this kinase by
2131:
Meyer CF, Wang X, Chang C, Templeton D, Tan TH (April 1996).
3368:
2268:"Regulation of two JunD isoforms by Jun N-terminal kinases"
5539:
2949:
Elion EA (September 1998). "Routing MAP kinase cascades".
2474:
Slack DN, Seternes OM, Gabrielsen M, Keyse SM (May 2001).
1561:(TNF-alpha) is found to be required for TNF-alpha-induced
3583:: Pyrazoloquinolones as Novel, Selective JNK1 inhibitors
3082:
Kelkar N, Gupta S, Dickens M, Davis RJ (February 2000).
495:
1899:"Entrez Gene: MAPK8 mitogen-activated protein kinase 8"
902:
regulation of DNA-binding transcription factor activity
3628:: Novel 4-anilinopyrimidines as potent JNK1 Inhibitors
5830:
3277:"Signal transduction by the JNK group of MAP kinases"
2695:
Gallagher E, Gao M, Liu YC, Karin M (February 2006).
660:
2759:
Cheng J, Yang J, Xia Y, Karin M, Su B (April 2000).
2227:"ASK1 is essential for JNK/SAPK activation by TRAF2"
2172:
Ishitani T, Takaesu G, Ninomiya-Tsuji J, Shibuya H,
1533:
The protein encoded by this gene is a member of the
5726:
5690:
5659:
5628:
5577:
5481:
5379:
5362:
5345:
5328:
5299:
5159:
5059:
5000:
4891:
4857:
4797:
4773:
4734:
4700:
4406:
4377:
4353:
4334:
4255:
4231:
4192:
4148:
4131:
4107:
4071:
4052:
4018:
3989:
3922:
3888:
3748:
1577:proliferation, apoptosis and differentiation. Four
1416:
1331:
1293:
1204:
1745:
1743:
1741:
1724:
1722:
1720:
2515:Wang T, Arifoglu P, Ronai Z, Tew KD (June 2001).
442:
341:
2754:
2752:
2750:
2016:
2014:
18:Protein-coding gene in the species Homo sapiens
2433:Tanoue T, Moriguchi T, Nishida E (July 1999).
2126:
2124:
2064:
2062:
2060:
2058:
1750:GRCm38: Ensembl release 89: ENSMUSG00000021936
5555:
3750:Non-specific serine/threonine protein kinases
3699:
3413:
1800:
1798:
8:
987:regulation of DNA replication origin binding
972:cellular response to reactive oxygen species
1729:GRCh38: Ensembl release 89: ENSG00000107643
917:positive regulation of deacetylase activity
5562:
5548:
5540:
5478:
5464:
4854:
4840:
4133:Goodpasture-antigen-binding protein kinase
3745:
3731:
3706:
3692:
3684:
3420:
3406:
3398:
3385:United States National Library of Medicine
1328:
1201:
1037:
967:cellular response to amino acid starvation
702:
483:
382:
279:
65:
4846:Serine/threonine-specific protein kinases
4020:(isocitrate dehydrogenase (NADP+)) kinase
3737:Serine/threonine-specific protein kinases
3719:Serine/threonine-specific protein kinases
3335:
3292:
3197:
3148:
3107:
3058:
3009:
2925:
2884:
2843:
2833:
2784:
2730:
2720:
2663:
2614:
2573:
2532:
2491:
2450:
2409:
2324:
2283:
2242:
2201:
2148:
2104:
2094:
2038:
1994:
1953:
1874:
5381:Receptor protein serine/threonine kinase
3383:This article incorporates text from the
952:positive regulation of apoptotic process
882:cellular response to mechanical stimulus
857:negative regulation of apoptotic process
750:protein serine/threonine kinase activity
5837:
5364:Low-density-lipoprotein receptor kinase
3435:
1716:
932:cellular response to lipopolysaccharide
927:positive regulation of cyclase activity
1581:transcript variants encoding distinct
1012:cellular response to cytokine stimulus
1007:cellular response to organic substance
892:positive regulation of gene expression
862:negative regulation of protein binding
745:histone deacetylase regulator activity
20:
4109:Fas-activated serine/threonine kinase
1514:(also known as JNK1) is a ubiquitous
872:Fc-epsilon receptor signaling pathway
447:
408:
403:
346:
305:
300:
7:
5390:Bone morphogenetic protein receptors
1553:, and thus mediates immediate-early
3924:Dephospho-(reductase kinase) kinase
947:regulation of histone deacetylation
4379:G-protein coupled receptor kinases
2384:Girardin SE, Yaniv M (July 2001).
2266:Yazgan O, Pfarr CM (August 2002).
1867:10.1002/j.1460-2075.1996.tb00636.x
1512:Mitogen-activated protein kinase 8
1413:
1290:
1177:
1158:
1132:
1113:
1087:
1068:
922:peptidyl-threonine phosphorylation
867:regulation of protein localization
665:
583:
521:
500:
14:
4369:Beta adrenergic receptor kinase-2
4054:(tyrosine 3-monooxygenase) kinase
1603:Activating transcription factor 2
1518:that in humans is encoded by the
1002:intracellular signal transduction
5840:
5061:Mitogen-activated protein kinase
3663:
3648:
3633:
3618:
3603:
3588:
3573:
3558:
3543:
3528:
3513:
3498:
3483:
3468:
3453:
3438:
982:cellular response to cadmium ion
676:
669:
431:
424:
418:
395:
330:
323:
317:
292:
29:
5447:Anti-MĂĽllerian hormone receptor
5330:(acetyl-CoA carboxylase) kinase
5002:(RNA-polymerase)-subunit kinase
4364:Beta adrenergic receptor kinase
4355:Beta adrenergic receptor kinase
3100:10.1128/mcb.20.3.1030-1043.2000
2908:Xu S, Cobb MH (December 1997).
2777:10.1128/mcb.20.7.2334-2342.2000
2176:, Matsumoto K (December 2003).
992:response to mechanical stimulus
907:peptidyl-serine phosphorylation
5070:Extracellular signal-regulated
912:regulation of circadian rhythm
687:More reference expression data
649:More reference expression data
1:
5134:P38 mitogen-activated protein
4233:cGMP-dependent protein kinase
4194:cAMP-dependent protein kinase
3890:Pyruvate dehydrogenase kinase
3836:Ataxia telangiectasia mutated
3294:10.1016/S0092-8674(00)00116-1
2963:10.1126/science.281.5383.1625
2244:10.1016/s1097-2765(00)80283-x
997:regulation of gene expression
977:stress-activated MAPK cascade
416:
315:
5863:Genes on human chromosome 10
3933:AMP-activated protein kinase
2814:Proc. Natl. Acad. Sci. U.S.A
2075:Proc. Natl. Acad. Sci. U.S.A
2021:Chen Z, Cobb MH (May 2001).
1820:10.1016/0092-8674(94)90380-8
942:regulation of macroautophagy
4848:(EC 2.7.11.21-EC 2.7.11.30)
3568:: Inhibitor complex of JNK3
3553:: inhibitor complex of JNK3
1559:tumor-necrosis factor alpha
740:histone deacetylase binding
549:stromal cell of endometrium
5884:
4775:Elongation factor 2 kinase
3739:(EC 2.7.11.1-EC 2.7.11.20)
615:superior cervical ganglion
5718:Michaelis–Menten kinetics
5477:
5463:
5170:MAP kinase kinase kinases
4853:
4839:
4702:Myosin light-chain kinase
4408:Ca2+/calmodulin-dependent
4073:Myosin-heavy-chain kinase
3744:
3730:
3433:
1785:"Mouse PubMed Reference:"
1767:"Human PubMed Reference:"
1498:
1493:
1489:
1482:
1466:
1447:
1420:
1355:
1324:
1297:
1228:
1197:
1184:
1180:
1165:
1161:
1152:
1139:
1135:
1120:
1116:
1107:
1094:
1090:
1075:
1071:
1062:
1047:
1040:
1036:
1020:
705:
701:
684:
668:
659:
646:
595:
586:
533:
524:
494:
486:
482:
465:
452:
415:
394:
385:
381:
364:
351:
314:
291:
282:
278:
233:
230:
220:
213:
208:
73:
68:
51:
46:
41:
37:
28:
23:
5610:Diffusion-limited enzyme
5470:Dual-specificity kinases
3150:10.1074/jbc.274.46.32580
2927:10.1074/jbc.272.51.32056
2452:10.1074/jbc.274.28.19949
2402:10.1093/emboj/20.13.3437
1996:10.1074/jbc.272.51.32163
1593:MAPK8 has been shown to
1453:Chr 10: 48.31 – 48.44 Mb
565:internal globus pallidus
541:tendon of biceps brachii
4893:Cyclin-dependent kinase
2722:10.1073/pnas.0510664103
2665:10.1126/science.1099414
2616:10.1074/jbc.275.12.9047
2363:10.1242/jcs.108.11.3599
2150:10.1074/jbc.271.15.8971
2096:10.1073/pnas.94.14.7337
1955:10.1074/jbc.270.13.7420
1460:Chr 14: 33.1 – 33.17 Mb
962:protein phosphorylation
730:protein kinase activity
3337:10.1038/sj.onc.1210417
3051:10.1128/mcb.19.11.7539
3011:10.1074/jbc.M109663200
2886:10.1074/jbc.M110299200
2835:10.1073/pnas.232310199
2575:10.1074/jbc.M101521200
2534:10.1074/jbc.M101355200
2493:10.1074/jbc.M010966200
2326:10.1074/jbc.M104837200
2285:10.1074/jbc.M204552200
2040:10.1074/jbc.M100681200
5703:Eadie–Hofstee diagram
5636:Allosteric regulation
3318:Liu J, Lin A (2007).
1551:transcription factors
410:Chromosome 14 (mouse)
308:Chromosome 10 (human)
5713:Lineweaver–Burk plot
4736:Phosphorylase kinase
3369:MAP Kinase Resource
2194:10.1093/emboj/cdg605
720:transferase activity
69:List of PDB id codes
42:Available structures
2826:2002PNAS...9914189L
2713:2006PNAS..103.1717G
2656:2004Sci...306..271G
2087:1997PNAS...94.7337T
1917:www.phosphosite.org
1579:alternately spliced
897:JUN phosphorylation
770:JUN kinase activity
735:MAP kinase activity
619:ganglionic eminence
573:epithelium of colon
561:islet of Langerhans
537:ganglionic eminence
5672:Enzyme superfamily
5605:Enzyme promiscuity
5347:Tropomyosin kinase
5301:Tau-protein kinase
3387:, which is in the
3374:2021-04-15 at the
3190:10.1042/BJ20020553
2527:(24): 20999–1003.
1142:ENSMUSG00000021936
957:neuron development
852:response to stress
835:Biological process
784:Cellular component
725:nucleotide binding
713:Molecular function
553:buccal mucosa cell
5828:
5827:
5537:
5536:
5533:
5532:
5529:
5528:
5459:
5458:
5455:
5454:
4835:
4834:
4831:
4830:
4316:Protein kinase N1
4271:Protein kinase Cζ
3681:
3680:
3275:Davis RJ (2000).
3254:Landes Bioscience
2486:(19): 16491–500.
1509:
1508:
1505:
1504:
1478:
1477:
1443:
1442:
1410:
1409:
1320:
1319:
1287:
1286:
1193:
1192:
1174:
1173:
1148:
1147:
1129:
1128:
1103:
1102:
1084:
1083:
1032:
1031:
816:neuron projection
697:
696:
693:
692:
655:
654:
642:
641:
623:perirhinal cortex
580:
579:
478:
477:
377:
376:
272:MAPK8 - orthologs
204:
203:
200:
199:
52:Ortholog search:
5875:
5845:
5844:
5836:
5708:Hanes–Woolf plot
5651:Enzyme activator
5646:Enzyme inhibitor
5620:Enzyme catalysis
5564:
5557:
5550:
5541:
5479:
5465:
5112:C-Jun N-terminal
4855:
4841:
4345:Rhodopsin kinase
4336:Rhodopsin kinase
4266:Protein kinase C
4257:Protein kinase C
4242:Protein kinase G
4203:Protein kinase A
3814:Protein kinase B
3746:
3732:
3708:
3701:
3694:
3685:
3667:
3652:
3637:
3622:
3607:
3592:
3577:
3562:
3547:
3532:
3517:
3502:
3487:
3472:
3457:
3442:
3422:
3415:
3408:
3399:
3357:
3339:
3314:
3296:
3271:
3239:
3238:
3218:
3212:
3211:
3201:
3184:(Pt 3): 577–85.
3169:
3163:
3162:
3152:
3128:
3122:
3121:
3111:
3079:
3073:
3072:
3062:
3030:
3024:
3023:
3013:
2989:
2983:
2982:
2957:(5383): 1625–6.
2946:
2940:
2939:
2929:
2920:(51): 32056–60.
2905:
2899:
2898:
2888:
2864:
2858:
2857:
2847:
2837:
2820:(22): 14189–94.
2805:
2799:
2798:
2788:
2756:
2745:
2744:
2734:
2724:
2692:
2686:
2685:
2667:
2635:
2629:
2628:
2618:
2594:
2588:
2587:
2577:
2553:
2547:
2546:
2536:
2512:
2506:
2505:
2495:
2471:
2465:
2464:
2454:
2445:(28): 19949–56.
2430:
2424:
2423:
2413:
2381:
2375:
2374:
2357:(11): 3599–609.
2345:
2339:
2338:
2328:
2304:
2298:
2297:
2287:
2263:
2257:
2256:
2246:
2222:
2216:
2215:
2205:
2169:
2163:
2162:
2152:
2128:
2119:
2118:
2108:
2098:
2066:
2053:
2052:
2042:
2018:
2009:
2008:
1998:
1974:
1968:
1967:
1957:
1933:
1927:
1926:
1924:
1923:
1909:
1903:
1902:
1895:
1889:
1888:
1878:
1846:
1840:
1839:
1802:
1793:
1792:
1781:
1775:
1774:
1763:
1757:
1747:
1736:
1726:
1491:
1490:
1462:
1455:
1438:
1414:
1405:
1329:
1325:RefSeq (protein)
1315:
1291:
1282:
1202:
1178:
1159:
1133:
1114:
1088:
1069:
1038:
847:rhythmic process
703:
689:
680:
673:
666:
651:
631:genital tubercle
603:secondary oocyte
591:
589:Top expressed in
584:
557:ventricular zone
529:
527:Top expressed in
522:
501:
484:
474:
461:
450:
435:
428:
422:
411:
399:
383:
373:
360:
349:
334:
327:
321:
310:
296:
280:
274:
225:
218:
195:
66:
60:
39:
38:
33:
21:
5883:
5882:
5878:
5877:
5876:
5874:
5873:
5872:
5853:
5852:
5851:
5839:
5831:
5829:
5824:
5736:Oxidoreductases
5722:
5698:Enzyme kinetics
5686:
5682:List of enzymes
5655:
5624:
5595:Catalytic triad
5573:
5568:
5538:
5525:
5473:
5451:
5375:
5358:
5341:
5324:
5295:
5155:
5055:
5026:P70-S6 Kinase 1
4996:
4887:
4849:
4827:
4793:
4769:
4730:
4696:
4402:
4373:
4349:
4330:
4251:
4227:
4188:
4144:
4127:
4103:
4097:Aurora C kinase
4092:Aurora B kinase
4087:Aurora A kinase
4067:
4048:
4014:
3985:
3918:
3884:
3740:
3726:
3712:
3682:
3677:
3674:
3668:
3659:
3653:
3644:
3638:
3629:
3623:
3614:
3608:
3599:
3593:
3584:
3578:
3569:
3563:
3554:
3548:
3539:
3533:
3524:
3518:
3509:
3503:
3494:
3488:
3479:
3473:
3464:
3458:
3449:
3443:
3429:
3426:
3395:
3376:Wayback Machine
3365:
3360:
3330:(22): 3267–78.
3317:
3274:
3268:
3251:
3247:
3245:Further reading
3242:
3220:
3219:
3215:
3171:
3170:
3166:
3143:(46): 32580–7.
3130:
3129:
3125:
3088:Mol. Cell. Biol
3081:
3080:
3076:
3045:(11): 7539–48.
3039:Mol. Cell. Biol
3032:
3031:
3027:
2991:
2990:
2986:
2948:
2947:
2943:
2907:
2906:
2902:
2866:
2865:
2861:
2807:
2806:
2802:
2765:Mol. Cell. Biol
2758:
2757:
2748:
2694:
2693:
2689:
2650:(5694): 271–5.
2637:
2636:
2632:
2609:(12): 9047–54.
2596:
2595:
2591:
2555:
2554:
2550:
2514:
2513:
2509:
2473:
2472:
2468:
2432:
2431:
2427:
2396:(13): 3437–46.
2383:
2382:
2378:
2347:
2346:
2342:
2319:(39): 36530–4.
2306:
2305:
2301:
2278:(33): 29710–8.
2265:
2264:
2260:
2224:
2223:
2219:
2188:(23): 6277–88.
2171:
2170:
2166:
2130:
2129:
2122:
2081:(14): 7337–42.
2068:
2067:
2056:
2033:(19): 16070–5.
2020:
2019:
2012:
1989:(51): 32163–8.
1976:
1975:
1971:
1935:
1934:
1930:
1921:
1919:
1911:
1910:
1906:
1897:
1896:
1892:
1861:(11): 2760–70.
1848:
1847:
1843:
1804:
1803:
1796:
1783:
1782:
1778:
1765:
1764:
1760:
1748:
1739:
1727:
1718:
1714:
1709:
1591:
1555:gene expression
1547:differentiation
1531:
1500:View/Edit Mouse
1495:View/Edit Human
1458:
1451:
1448:Location (UCSC)
1434:
1430:
1426:
1422:
1401:
1397:
1393:
1389:
1385:
1381:
1377:
1373:
1369:
1365:
1361:
1357:
1351:
1347:
1343:
1339:
1335:
1311:
1307:
1303:
1299:
1278:
1274:
1270:
1266:
1262:
1258:
1254:
1250:
1246:
1242:
1238:
1234:
1230:
1224:
1220:
1216:
1212:
1208:
1123:ENSG00000107643
1016:
842:phosphorylation
830:
779:
775:kinase activity
755:protein binding
685:
675:
674:
647:
638:
635:piriform cortex
633:
629:
625:
621:
617:
613:
609:
605:
601:
587:
576:
571:
567:
563:
559:
555:
551:
547:
545:Achilles tendon
543:
539:
525:
469:
456:
448:
438:
437:
436:
429:
409:
386:Gene location (
368:
355:
347:
337:
336:
335:
328:
306:
283:Gene location (
234:
221:
214:
75:
53:
19:
12:
11:
5:
5881:
5879:
5871:
5870:
5865:
5855:
5854:
5850:
5849:
5826:
5825:
5823:
5822:
5809:
5796:
5783:
5770:
5757:
5744:
5730:
5728:
5724:
5723:
5721:
5720:
5715:
5710:
5705:
5700:
5694:
5692:
5688:
5687:
5685:
5684:
5679:
5674:
5669:
5663:
5661:
5660:Classification
5657:
5656:
5654:
5653:
5648:
5643:
5638:
5632:
5630:
5626:
5625:
5623:
5622:
5617:
5612:
5607:
5602:
5597:
5592:
5587:
5581:
5579:
5575:
5574:
5569:
5567:
5566:
5559:
5552:
5544:
5535:
5534:
5531:
5530:
5527:
5526:
5524:
5523:
5518:
5513:
5508:
5503:
5498:
5493:
5487:
5485:
5475:
5474:
5468:
5461:
5460:
5457:
5456:
5453:
5452:
5450:
5449:
5444:
5439:
5434:
5429:
5424:
5419:
5414:
5413:
5412:
5407:
5402:
5397:
5386:
5384:
5383:(EC 2.7.11.30)
5377:
5376:
5374:
5373:
5369:
5367:
5366:(EC 2.7.11.29)
5360:
5359:
5357:
5356:
5352:
5350:
5349:(EC 2.7.11.28)
5343:
5342:
5340:
5339:
5335:
5333:
5332:(EC 2.7.11.27)
5326:
5325:
5323:
5322:
5317:
5312:
5306:
5304:
5303:(EC 2.7.11.26)
5297:
5296:
5294:
5293:
5288:
5283:
5282:
5281:
5276:
5271:
5266:
5261:
5256:
5251:
5241:
5240:
5239:
5234:
5229:
5224:
5214:
5213:
5212:
5207:
5202:
5197:
5192:
5187:
5182:
5177:
5166:
5164:
5163:(EC 2.7.11.25)
5157:
5156:
5154:
5153:
5152:
5151:
5146:
5141:
5131:
5130:
5129:
5124:
5119:
5109:
5108:
5107:
5102:
5097:
5092:
5087:
5082:
5077:
5066:
5064:
5063:(EC 2.7.11.24)
5057:
5056:
5054:
5053:
5048:
5043:
5038:
5033:
5028:
5023:
5018:
5013:
5007:
5005:
5004:(EC 2.7.11.23)
4998:
4997:
4995:
4994:
4989:
4984:
4979:
4974:
4969:
4964:
4959:
4954:
4949:
4944:
4939:
4934:
4929:
4924:
4919:
4914:
4909:
4904:
4898:
4896:
4895:(EC 2.7.11.22)
4889:
4888:
4886:
4885:
4880:
4875:
4870:
4864:
4862:
4861:(EC 2.7.11.21)
4851:
4850:
4844:
4837:
4836:
4833:
4832:
4829:
4828:
4826:
4825:
4820:
4815:
4810:
4804:
4802:
4801:(EC 2.7.11.21)
4795:
4794:
4792:
4791:
4786:
4780:
4778:
4777:(EC 2.7.11.20)
4771:
4770:
4768:
4767:
4762:
4757:
4752:
4747:
4741:
4739:
4738:(EC 2.7.11.19)
4732:
4731:
4729:
4728:
4723:
4718:
4713:
4707:
4705:
4704:(EC 2.7.11.18)
4698:
4697:
4695:
4694:
4689:
4684:
4679:
4674:
4669:
4664:
4659:
4654:
4649:
4644:
4639:
4634:
4629:
4624:
4619:
4614:
4609:
4604:
4599:
4594:
4589:
4584:
4579:
4574:
4569:
4564:
4559:
4554:
4549:
4544:
4539:
4534:
4529:
4524:
4519:
4514:
4509:
4504:
4499:
4494:
4489:
4484:
4479:
4474:
4469:
4464:
4459:
4454:
4449:
4444:
4439:
4434:
4429:
4424:
4419:
4413:
4411:
4410:(EC 2.7.11.17)
4404:
4403:
4401:
4400:
4395:
4390:
4384:
4382:
4381:(EC 2.7.11.16)
4375:
4374:
4372:
4371:
4366:
4360:
4358:
4357:(EC 2.7.11.15)
4351:
4350:
4348:
4347:
4341:
4339:
4338:(EC 2.7.11.14)
4332:
4331:
4329:
4328:
4323:
4318:
4313:
4308:
4303:
4298:
4293:
4288:
4283:
4278:
4273:
4268:
4262:
4260:
4259:(EC 2.7.11.13)
4253:
4252:
4250:
4249:
4244:
4238:
4236:
4235:(EC 2.7.11.12)
4229:
4228:
4226:
4225:
4220:
4215:
4210:
4205:
4199:
4197:
4196:(EC 2.7.11.11)
4190:
4189:
4187:
4186:
4181:
4176:
4171:
4166:
4161:
4155:
4153:
4152:(EC 2.7.11.10)
4146:
4145:
4143:
4142:
4138:
4136:
4129:
4128:
4126:
4125:
4120:
4114:
4112:
4105:
4104:
4102:
4101:
4100:
4099:
4094:
4089:
4078:
4076:
4069:
4068:
4066:
4065:
4059:
4057:
4050:
4049:
4047:
4046:
4041:
4036:
4031:
4025:
4023:
4016:
4015:
4013:
4012:
4007:
4002:
3996:
3994:
3987:
3986:
3984:
3983:
3982:
3981:
3976:
3971:
3963:
3962:
3961:
3956:
3948:
3947:
3946:
3941:
3929:
3927:
3920:
3919:
3917:
3916:
3911:
3906:
3901:
3895:
3893:
3886:
3885:
3883:
3882:
3881:
3880:
3870:
3869:
3868:
3863:
3858:
3853:
3843:
3838:
3833:
3832:
3831:
3826:
3821:
3811:
3806:
3801:
3796:
3791:
3786:
3781:
3776:
3771:
3766:
3761:
3755:
3753:
3742:
3741:
3735:
3728:
3727:
3713:
3711:
3710:
3703:
3696:
3688:
3679:
3678:
3676:
3675:
3669:
3662:
3660:
3654:
3647:
3645:
3639:
3632:
3630:
3624:
3617:
3615:
3609:
3602:
3600:
3594:
3587:
3585:
3579:
3572:
3570:
3564:
3557:
3555:
3549:
3542:
3540:
3534:
3527:
3525:
3519:
3512:
3510:
3504:
3497:
3495:
3489:
3482:
3480:
3474:
3467:
3465:
3459:
3452:
3450:
3444:
3437:
3434:
3431:
3430:
3427:
3425:
3424:
3417:
3410:
3402:
3380:
3379:
3364:
3363:External links
3361:
3359:
3358:
3315:
3272:
3267:978-1587061202
3266:
3248:
3246:
3243:
3241:
3240:
3213:
3164:
3123:
3094:(3): 1030–43.
3074:
3025:
3004:(2): 1217–22.
2984:
2941:
2900:
2859:
2800:
2771:(7): 2334–42.
2746:
2707:(6): 1717–22.
2687:
2630:
2589:
2548:
2507:
2466:
2425:
2376:
2340:
2299:
2258:
2217:
2164:
2143:(15): 8971–6.
2120:
2054:
2010:
1969:
1948:(13): 7420–6.
1928:
1913:"JNK1 (human)"
1904:
1890:
1841:
1814:(6): 1025–37.
1794:
1776:
1758:
1737:
1715:
1713:
1710:
1708:
1707:
1701:
1695:
1689:
1683:
1677:
1671:
1665:
1660:
1654:
1648:
1642:
1636:
1630:
1624:
1618:
1612:
1606:
1599:
1590:
1587:
1530:
1527:
1507:
1506:
1503:
1502:
1497:
1487:
1486:
1480:
1479:
1476:
1475:
1473:
1471:
1464:
1463:
1456:
1449:
1445:
1444:
1441:
1440:
1418:
1417:
1411:
1408:
1407:
1353:
1352:
1326:
1322:
1321:
1318:
1317:
1295:
1294:
1288:
1285:
1284:
1226:
1225:
1199:
1195:
1194:
1191:
1190:
1182:
1181:
1175:
1172:
1171:
1163:
1162:
1156:
1150:
1149:
1146:
1145:
1137:
1136:
1130:
1127:
1126:
1118:
1117:
1111:
1105:
1104:
1101:
1100:
1092:
1091:
1085:
1082:
1081:
1073:
1072:
1066:
1060:
1059:
1054:
1049:
1045:
1044:
1034:
1033:
1030:
1029:
1018:
1017:
1015:
1014:
1009:
1004:
999:
994:
989:
984:
979:
974:
969:
964:
959:
954:
949:
944:
939:
937:response to UV
934:
929:
924:
919:
914:
909:
904:
899:
894:
889:
884:
879:
874:
869:
864:
859:
854:
849:
844:
838:
836:
832:
831:
829:
828:
826:basal dendrite
823:
818:
813:
808:
803:
798:
793:
787:
785:
781:
780:
778:
777:
772:
767:
762:
760:enzyme binding
757:
752:
747:
742:
737:
732:
727:
722:
716:
714:
710:
709:
699:
698:
695:
694:
691:
690:
682:
681:
663:
657:
656:
653:
652:
644:
643:
640:
639:
637:
636:
632:
628:
624:
620:
616:
612:
608:
607:primary oocyte
604:
600:
596:
593:
592:
581:
578:
577:
575:
574:
570:
566:
562:
558:
554:
550:
546:
542:
538:
534:
531:
530:
518:
517:
509:
498:
492:
491:
488:RNA expression
480:
479:
476:
475:
467:
463:
462:
454:
451:
446:
440:
439:
430:
423:
417:
413:
412:
407:
401:
400:
392:
391:
379:
378:
375:
374:
366:
362:
361:
353:
350:
345:
339:
338:
329:
322:
316:
312:
311:
304:
298:
297:
289:
288:
276:
275:
232:
228:
227:
219:
211:
210:
206:
205:
202:
201:
198:
197:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
17:
13:
10:
9:
6:
4:
3:
2:
5880:
5869:
5866:
5864:
5861:
5860:
5858:
5848:
5843:
5838:
5834:
5820:
5816:
5815:
5810:
5807:
5803:
5802:
5797:
5794:
5790:
5789:
5784:
5781:
5777:
5776:
5771:
5768:
5764:
5763:
5758:
5755:
5751:
5750:
5745:
5742:
5738:
5737:
5732:
5731:
5729:
5725:
5719:
5716:
5714:
5711:
5709:
5706:
5704:
5701:
5699:
5696:
5695:
5693:
5689:
5683:
5680:
5678:
5677:Enzyme family
5675:
5673:
5670:
5668:
5665:
5664:
5662:
5658:
5652:
5649:
5647:
5644:
5642:
5641:Cooperativity
5639:
5637:
5634:
5633:
5631:
5627:
5621:
5618:
5616:
5613:
5611:
5608:
5606:
5603:
5601:
5600:Oxyanion hole
5598:
5596:
5593:
5591:
5588:
5586:
5583:
5582:
5580:
5576:
5572:
5565:
5560:
5558:
5553:
5551:
5546:
5545:
5542:
5522:
5519:
5517:
5514:
5512:
5509:
5507:
5504:
5502:
5499:
5497:
5494:
5492:
5489:
5488:
5486:
5484:
5480:
5476:
5471:
5466:
5462:
5448:
5445:
5443:
5440:
5438:
5435:
5433:
5430:
5428:
5425:
5423:
5420:
5418:
5415:
5411:
5408:
5406:
5403:
5401:
5398:
5396:
5393:
5392:
5391:
5388:
5387:
5385:
5382:
5378:
5371:
5370:
5368:
5365:
5361:
5354:
5353:
5351:
5348:
5344:
5337:
5336:
5334:
5331:
5327:
5321:
5318:
5316:
5313:
5311:
5308:
5307:
5305:
5302:
5298:
5292:
5289:
5287:
5284:
5280:
5277:
5275:
5272:
5270:
5267:
5265:
5262:
5260:
5257:
5255:
5252:
5250:
5247:
5246:
5245:
5242:
5238:
5235:
5233:
5230:
5228:
5225:
5223:
5220:
5219:
5218:
5215:
5211:
5208:
5206:
5203:
5201:
5198:
5196:
5193:
5191:
5188:
5186:
5183:
5181:
5178:
5176:
5173:
5172:
5171:
5168:
5167:
5165:
5162:
5158:
5150:
5147:
5145:
5142:
5140:
5137:
5136:
5135:
5132:
5128:
5125:
5123:
5120:
5118:
5115:
5114:
5113:
5110:
5106:
5103:
5101:
5098:
5096:
5093:
5091:
5088:
5086:
5083:
5081:
5078:
5076:
5073:
5072:
5071:
5068:
5067:
5065:
5062:
5058:
5052:
5049:
5047:
5044:
5042:
5039:
5037:
5034:
5032:
5029:
5027:
5024:
5022:
5019:
5017:
5014:
5012:
5009:
5008:
5006:
5003:
4999:
4993:
4990:
4988:
4985:
4983:
4980:
4978:
4975:
4973:
4970:
4968:
4965:
4963:
4960:
4958:
4955:
4953:
4950:
4948:
4945:
4943:
4940:
4938:
4935:
4933:
4930:
4928:
4925:
4923:
4920:
4918:
4915:
4913:
4910:
4908:
4905:
4903:
4900:
4899:
4897:
4894:
4890:
4884:
4881:
4879:
4876:
4874:
4871:
4869:
4866:
4865:
4863:
4860:
4856:
4852:
4847:
4842:
4838:
4824:
4821:
4819:
4816:
4814:
4811:
4809:
4806:
4805:
4803:
4800:
4796:
4790:
4787:
4785:
4782:
4781:
4779:
4776:
4772:
4766:
4763:
4761:
4758:
4756:
4753:
4751:
4748:
4746:
4743:
4742:
4740:
4737:
4733:
4727:
4724:
4722:
4719:
4717:
4714:
4712:
4709:
4708:
4706:
4703:
4699:
4693:
4690:
4688:
4685:
4683:
4680:
4678:
4675:
4673:
4670:
4668:
4665:
4663:
4660:
4658:
4655:
4653:
4650:
4648:
4645:
4643:
4640:
4638:
4635:
4633:
4630:
4628:
4625:
4623:
4620:
4618:
4615:
4613:
4610:
4608:
4605:
4603:
4600:
4598:
4595:
4593:
4590:
4588:
4585:
4583:
4580:
4578:
4575:
4573:
4570:
4568:
4565:
4563:
4560:
4558:
4555:
4553:
4550:
4548:
4545:
4543:
4540:
4538:
4535:
4533:
4530:
4528:
4525:
4523:
4520:
4518:
4515:
4513:
4510:
4508:
4505:
4503:
4500:
4498:
4495:
4493:
4490:
4488:
4485:
4483:
4480:
4478:
4475:
4473:
4470:
4468:
4465:
4463:
4460:
4458:
4455:
4453:
4450:
4448:
4445:
4443:
4440:
4438:
4435:
4433:
4430:
4428:
4425:
4423:
4420:
4418:
4415:
4414:
4412:
4409:
4405:
4399:
4396:
4394:
4391:
4389:
4386:
4385:
4383:
4380:
4376:
4370:
4367:
4365:
4362:
4361:
4359:
4356:
4352:
4346:
4343:
4342:
4340:
4337:
4333:
4327:
4324:
4322:
4319:
4317:
4314:
4312:
4309:
4307:
4304:
4302:
4299:
4297:
4294:
4292:
4289:
4287:
4284:
4282:
4279:
4277:
4274:
4272:
4269:
4267:
4264:
4263:
4261:
4258:
4254:
4248:
4245:
4243:
4240:
4239:
4237:
4234:
4230:
4224:
4221:
4219:
4216:
4214:
4211:
4209:
4206:
4204:
4201:
4200:
4198:
4195:
4191:
4185:
4182:
4180:
4177:
4175:
4172:
4170:
4167:
4165:
4162:
4160:
4157:
4156:
4154:
4151:
4147:
4140:
4139:
4137:
4135:(EC 2.7.11.9)
4134:
4130:
4124:
4121:
4119:
4116:
4115:
4113:
4111:(EC 2.7.11.8)
4110:
4106:
4098:
4095:
4093:
4090:
4088:
4085:
4084:
4083:
4082:Aurora kinase
4080:
4079:
4077:
4075:(EC 2.7.11.7)
4074:
4070:
4064:
4061:
4060:
4058:
4056:(EC 2.7.11.6)
4055:
4051:
4045:
4042:
4040:
4037:
4035:
4032:
4030:
4027:
4026:
4024:
4022:(EC 2.7.11.5)
4021:
4017:
4011:
4008:
4006:
4003:
4001:
3998:
3997:
3995:
3993:(EC 2.7.11.4)
3992:
3988:
3980:
3977:
3975:
3972:
3970:
3967:
3966:
3964:
3960:
3957:
3955:
3952:
3951:
3949:
3945:
3942:
3940:
3937:
3936:
3934:
3931:
3930:
3928:
3926:(EC 2.7.11.3)
3925:
3921:
3915:
3912:
3910:
3907:
3905:
3902:
3900:
3897:
3896:
3894:
3892:(EC 2.7.11.2)
3891:
3887:
3879:
3876:
3875:
3874:
3871:
3867:
3864:
3862:
3859:
3857:
3854:
3852:
3849:
3848:
3847:
3846:EIF-2 kinases
3844:
3842:
3839:
3837:
3834:
3830:
3827:
3825:
3822:
3820:
3817:
3816:
3815:
3812:
3810:
3807:
3805:
3802:
3800:
3797:
3795:
3792:
3790:
3787:
3785:
3782:
3780:
3777:
3775:
3772:
3770:
3767:
3765:
3762:
3760:
3757:
3756:
3754:
3752:(EC 2.7.11.1)
3751:
3747:
3743:
3738:
3733:
3729:
3724:
3720:
3716:
3709:
3704:
3702:
3697:
3695:
3690:
3689:
3686:
3672:
3666:
3661:
3657:
3651:
3646:
3642:
3636:
3631:
3627:
3621:
3616:
3612:
3606:
3601:
3597:
3591:
3586:
3582:
3576:
3571:
3567:
3561:
3556:
3552:
3546:
3541:
3537:
3531:
3526:
3522:
3516:
3511:
3507:
3501:
3496:
3492:
3486:
3481:
3477:
3471:
3466:
3462:
3456:
3451:
3447:
3441:
3436:
3432:
3423:
3418:
3416:
3411:
3409:
3404:
3403:
3400:
3396:
3393:
3392:
3390:
3389:public domain
3386:
3377:
3373:
3370:
3367:
3366:
3362:
3355:
3351:
3347:
3343:
3338:
3333:
3329:
3325:
3321:
3316:
3312:
3308:
3304:
3300:
3295:
3290:
3287:(2): 239–52.
3286:
3282:
3278:
3273:
3269:
3263:
3259:
3255:
3250:
3249:
3244:
3236:
3232:
3229:(4): 863–73.
3228:
3224:
3217:
3214:
3209:
3205:
3200:
3195:
3191:
3187:
3183:
3179:
3175:
3168:
3165:
3160:
3156:
3151:
3146:
3142:
3138:
3137:J. Biol. Chem
3134:
3127:
3124:
3119:
3115:
3110:
3105:
3101:
3097:
3093:
3089:
3085:
3078:
3075:
3070:
3066:
3061:
3056:
3052:
3048:
3044:
3040:
3036:
3029:
3026:
3021:
3017:
3012:
3007:
3003:
2999:
2998:J. Biol. Chem
2995:
2988:
2985:
2980:
2976:
2972:
2968:
2964:
2960:
2956:
2952:
2945:
2942:
2937:
2933:
2928:
2923:
2919:
2915:
2914:J. Biol. Chem
2911:
2904:
2901:
2896:
2892:
2887:
2882:
2879:(4): 2573–8.
2878:
2874:
2873:J. Biol. Chem
2870:
2863:
2860:
2855:
2851:
2846:
2841:
2836:
2831:
2827:
2823:
2819:
2815:
2811:
2804:
2801:
2796:
2792:
2787:
2782:
2778:
2774:
2770:
2766:
2762:
2755:
2753:
2751:
2747:
2742:
2738:
2733:
2728:
2723:
2718:
2714:
2710:
2706:
2702:
2698:
2691:
2688:
2683:
2679:
2675:
2671:
2666:
2661:
2657:
2653:
2649:
2645:
2641:
2634:
2631:
2626:
2622:
2617:
2612:
2608:
2604:
2603:J. Biol. Chem
2600:
2593:
2590:
2585:
2581:
2576:
2571:
2568:(2): 1531–7.
2567:
2563:
2562:J. Biol. Chem
2559:
2552:
2549:
2544:
2540:
2535:
2530:
2526:
2522:
2521:J. Biol. Chem
2518:
2511:
2508:
2503:
2499:
2494:
2489:
2485:
2481:
2480:J. Biol. Chem
2477:
2470:
2467:
2462:
2458:
2453:
2448:
2444:
2440:
2439:J. Biol. Chem
2436:
2429:
2426:
2421:
2417:
2412:
2407:
2403:
2399:
2395:
2391:
2387:
2380:
2377:
2372:
2368:
2364:
2360:
2356:
2352:
2344:
2341:
2336:
2332:
2327:
2322:
2318:
2314:
2313:J. Biol. Chem
2310:
2303:
2300:
2295:
2291:
2286:
2281:
2277:
2273:
2272:J. Biol. Chem
2269:
2262:
2259:
2254:
2250:
2245:
2240:
2237:(3): 389–95.
2236:
2232:
2228:
2221:
2218:
2213:
2209:
2204:
2199:
2195:
2191:
2187:
2183:
2179:
2175:
2168:
2165:
2160:
2156:
2151:
2146:
2142:
2138:
2137:J. Biol. Chem
2134:
2127:
2125:
2121:
2116:
2112:
2107:
2102:
2097:
2092:
2088:
2084:
2080:
2076:
2072:
2065:
2063:
2061:
2059:
2055:
2050:
2046:
2041:
2036:
2032:
2028:
2027:J. Biol. Chem
2024:
2017:
2015:
2011:
2006:
2002:
1997:
1992:
1988:
1984:
1983:J. Biol. Chem
1980:
1973:
1970:
1965:
1961:
1956:
1951:
1947:
1943:
1942:J. Biol. Chem
1939:
1932:
1929:
1918:
1914:
1908:
1905:
1900:
1894:
1891:
1886:
1882:
1877:
1872:
1868:
1864:
1860:
1856:
1852:
1845:
1842:
1837:
1833:
1829:
1825:
1821:
1817:
1813:
1809:
1801:
1799:
1795:
1790:
1786:
1780:
1777:
1772:
1768:
1762:
1759:
1755:
1751:
1746:
1744:
1742:
1738:
1734:
1730:
1725:
1723:
1721:
1717:
1711:
1705:
1702:
1699:
1696:
1693:
1690:
1687:
1684:
1681:
1678:
1675:
1672:
1669:
1666:
1664:
1661:
1658:
1655:
1652:
1649:
1646:
1643:
1640:
1637:
1634:
1631:
1628:
1625:
1622:
1619:
1616:
1613:
1610:
1607:
1604:
1601:
1600:
1598:
1596:
1588:
1586:
1584:
1580:
1576:
1572:
1568:
1564:
1560:
1556:
1552:
1548:
1544:
1543:proliferation
1540:
1536:
1528:
1526:
1524:
1521:
1517:
1513:
1501:
1496:
1492:
1488:
1485:
1481:
1474:
1472:
1469:
1465:
1461:
1457:
1454:
1450:
1446:
1439:
1437:
1433:
1429:
1425:
1419:
1415:
1412:
1406:
1404:
1400:
1396:
1392:
1388:
1384:
1380:
1376:
1372:
1368:
1364:
1360:
1354:
1350:
1346:
1342:
1338:
1334:
1330:
1327:
1323:
1316:
1314:
1310:
1306:
1302:
1296:
1292:
1289:
1283:
1281:
1277:
1273:
1269:
1265:
1261:
1257:
1253:
1249:
1245:
1241:
1237:
1233:
1227:
1223:
1219:
1215:
1211:
1207:
1203:
1200:
1198:RefSeq (mRNA)
1196:
1189:
1188:
1183:
1179:
1176:
1170:
1169:
1164:
1160:
1157:
1155:
1151:
1144:
1143:
1138:
1134:
1131:
1125:
1124:
1119:
1115:
1112:
1110:
1106:
1099:
1098:
1093:
1089:
1086:
1080:
1079:
1074:
1070:
1067:
1065:
1061:
1058:
1055:
1053:
1050:
1046:
1043:
1039:
1035:
1028:
1024:
1019:
1013:
1010:
1008:
1005:
1003:
1000:
998:
995:
993:
990:
988:
985:
983:
980:
978:
975:
973:
970:
968:
965:
963:
960:
958:
955:
953:
950:
948:
945:
943:
940:
938:
935:
933:
930:
928:
925:
923:
920:
918:
915:
913:
910:
908:
905:
903:
900:
898:
895:
893:
890:
888:
885:
883:
880:
878:
875:
873:
870:
868:
865:
863:
860:
858:
855:
853:
850:
848:
845:
843:
840:
839:
837:
834:
833:
827:
824:
822:
819:
817:
814:
812:
809:
807:
806:mitochondrion
804:
802:
799:
797:
794:
792:
789:
788:
786:
783:
782:
776:
773:
771:
768:
766:
763:
761:
758:
756:
753:
751:
748:
746:
743:
741:
738:
736:
733:
731:
728:
726:
723:
721:
718:
717:
715:
712:
711:
708:
707:Gene ontology
704:
700:
688:
683:
679:
672:
667:
664:
662:
658:
650:
645:
634:
630:
627:visual cortex
626:
622:
618:
614:
611:barrel cortex
610:
606:
602:
598:
597:
594:
590:
585:
582:
572:
568:
564:
560:
556:
552:
548:
544:
540:
536:
535:
532:
528:
523:
520:
519:
516:
514:
510:
508:
507:
503:
502:
499:
497:
493:
489:
485:
481:
473:
468:
464:
460:
455:
445:
441:
434:
427:
421:
414:
406:
402:
398:
393:
389:
384:
380:
372:
367:
363:
359:
354:
344:
340:
333:
326:
320:
313:
309:
303:
299:
295:
290:
286:
281:
277:
273:
269:
265:
261:
257:
253:
249:
245:
241:
237:
229:
224:
217:
212:
207:
196:
194:
190:
186:
182:
178:
174:
170:
166:
162:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
114:
110:
106:
102:
98:
94:
90:
86:
82:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
16:
5814:Translocases
5811:
5798:
5785:
5772:
5759:
5749:Transferases
5746:
5733:
5590:Binding site
5116:
5021:P70S6 kinase
3670:
3655:
3640:
3625:
3610:
3595:
3580:
3565:
3550:
3535:
3520:
3505:
3490:
3475:
3460:
3445:
3394:
3382:
3381:
3327:
3323:
3284:
3280:
3257:
3253:
3226:
3222:
3216:
3181:
3177:
3167:
3140:
3136:
3126:
3091:
3087:
3077:
3042:
3038:
3028:
3001:
2997:
2987:
2954:
2950:
2944:
2917:
2913:
2903:
2876:
2872:
2862:
2817:
2813:
2803:
2768:
2764:
2704:
2700:
2690:
2647:
2643:
2633:
2606:
2602:
2592:
2565:
2561:
2551:
2524:
2520:
2510:
2483:
2479:
2469:
2442:
2438:
2428:
2393:
2389:
2379:
2354:
2350:
2343:
2316:
2312:
2302:
2275:
2271:
2261:
2234:
2230:
2220:
2185:
2181:
2167:
2140:
2136:
2078:
2074:
2030:
2026:
1986:
1982:
1972:
1945:
1941:
1931:
1920:. Retrieved
1916:
1907:
1893:
1858:
1854:
1844:
1811:
1807:
1788:
1779:
1770:
1761:
1592:
1589:Interactions
1571:cytochrome c
1532:
1519:
1511:
1510:
1432:NP_001297383
1428:NP_001297382
1424:NP_001297381
1421:
1395:NP_001310260
1391:NP_001310259
1387:NP_001310258
1383:NP_001310257
1379:NP_001310256
1375:NP_001310255
1371:NP_001310254
1367:NP_001310253
1363:NP_001310252
1359:NP_001310251
1356:
1349:NP_001310250
1345:NP_001310249
1341:NP_001310231
1337:NP_001265477
1333:NP_001265476
1309:NM_001310454
1305:NM_001310453
1301:NM_001310452
1298:
1280:NM_001323331
1276:NM_001323330
1272:NM_001323329
1268:NM_001323328
1264:NM_001323327
1260:NM_001323326
1256:NM_001323325
1252:NM_001323324
1248:NM_001323323
1244:NM_001323322
1240:NM_001323321
1236:NM_001323320
1232:NM_001323302
1229:
1210:NM_001278548
1206:NM_001278547
1185:
1166:
1140:
1121:
1095:
1076:
1056:
1051:
511:
504:
449:14|14 B
231:External IDs
74:
15:
5585:Active site
5472:(EC 2.7.12)
4859:Polo kinase
4799:Polo kinase
3428:PDB gallery
2351:J. Cell Sci
877:JNK cascade
796:nucleoplasm
765:ATP binding
569:gallbladder
470:33,169,115
457:33,099,855
369:48,439,360
356:48,306,639
209:Identifiers
5857:Categories
5788:Isomerases
5762:Hydrolases
5629:Regulation
4150:IÎşB kinase
3725:2.7.11-12)
3178:Biochem. J
1922:2020-10-28
1756:, May 2017
1735:, May 2017
1712:References
1535:MAP kinase
515:(ortholog)
252:HomoloGene
5868:EC 2.7.11
5667:EC number
4276:PKC alpha
2231:Mol. Cell
2174:Gaynor RB
1597:with:
1563:apoptosis
1436:NP_057909
1403:NP_620637
1399:NP_620634
1313:NM_016700
1222:NM_139049
1218:NM_139046
1214:NM_002750
1042:Orthologs
811:cytoplasm
260:GeneCards
5691:Kinetics
5615:Cofactor
5578:Activity
4632:KIAA0999
4527:MAPKAPK5
4522:MAPKAPK3
4517:MAPKAPK2
3372:Archived
3354:28428831
3346:17496921
3324:Oncogene
3303:11057897
3260:: 1–97.
3223:Oncogene
3208:12167088
3159:10551811
3118:10629060
3069:10523642
3020:11700324
2979:28868990
2895:11707464
2854:12391307
2795:10713157
2741:16446428
2682:31876966
2674:15358865
2625:10722755
2584:11606564
2543:11279197
2502:11278799
2461:10391943
2420:11432831
2335:11479302
2294:12052834
2212:14633987
2049:11279118
1752:–
1731:–
1680:MAPK8IP3
1674:MAPK8IP1
1595:interact
1583:isoforms
1529:Function
1484:Wikidata
1021:Sources:
348:10q11.22
5847:Biology
5801:Ligases
5571:Enzymes
5291:MAP3K14
5269:MAP3K11
5264:MAP3K10
5254:MAP3K13
5249:MAP3K12
5051:RPS6KC1
5046:RPS6KA1
5041:RPS6KA3
5036:RPS6KA2
5031:RPS6KB2
5016:RPS6KA4
5011:RPS6KA5
4662:Kalirin
4627:SNF1LK2
3866:EIF2AK4
3861:EIF2AK3
3715:Kinases
3235:8632909
3199:1222945
2971:9767029
2951:Science
2936:9405400
2822:Bibcode
2732:1413664
2709:Bibcode
2652:Bibcode
2644:Science
2371:8586671
2253:9774977
2159:8621542
2115:9207092
2083:Bibcode
2005:9405416
1964:7535770
1885:8654373
1836:6797795
1828:8137421
1754:Ensembl
1733:Ensembl
1565:. This
1154:UniProt
1109:Ensembl
1048:Species
1027:QuickGO
801:nucleus
791:cytosol
490:pattern
248:1346861
216:Aliases
5833:Portal
5775:Lyases
5521:MAP2K7
5516:MAP2K6
5511:MAP2K5
5506:MAP2K4
5501:MAP2K3
5496:MAP2K2
5491:MAP2K1
5442:ACVRL1
5437:ACVR2B
5432:ACVR2A
5427:ACVR1C
5422:ACVR1B
5405:BMPR1B
5400:BMPR1A
5274:MAP3K7
5259:MAP3K9
5210:MAP3K8
5205:MAP3K7
5200:MAP3K6
5195:MAP3K5
5190:MAP3K4
5185:MAP3K3
5180:MAP3K2
5175:MAP3K1
5149:MAPK14
5144:MAPK13
5139:MAPK11
5127:MAPK10
5105:MAPK15
5100:MAPK12
4992:CDC2L1
4967:CDC2L5
4642:SNF1LK
4467:CAMK2G
4462:CAMK2D
4457:CAMK2B
4452:CAMK2A
4442:CAMK1G
4437:CAMK1D
4432:CAMK1B
4427:CAMK1A
4281:PRKCB1
4218:PRKACA
4213:PRKACB
4208:PRKACG
4184:IKBKAP
4010:BCKDHB
4005:BCKDHA
3979:PRKAG3
3974:PRKAG2
3969:PRKAG1
3959:PRKAB2
3954:PRKAB1
3944:PRKAA2
3939:PRKAA1
3784:STK38L
3352:
3344:
3311:343677
3309:
3301:
3264:
3233:
3206:
3196:
3157:
3116:
3106:
3067:
3057:
3018:
2977:
2969:
2934:
2893:
2852:
2845:137859
2842:
2793:
2783:
2739:
2729:
2680:
2672:
2623:
2582:
2541:
2500:
2459:
2418:
2411:125507
2408:
2390:EMBO J
2369:
2333:
2292:
2251:
2210:
2203:291846
2200:
2182:EMBO J
2157:
2113:
2103:
2047:
2003:
1962:
1883:
1876:450211
1873:
1855:EMBO J
1834:
1826:
1700:, and
1698:SH3BP5
1668:MAP3K2
1663:MAP3K1
1657:MAP2K7
1651:MAP2K4
1621:DUSP10
1575:T cell
1567:kinase
1516:enzyme
1470:search
1468:PubMed
1187:Q91Y86
1168:P45983
1064:Entrez
661:BioGPS
599:zygote
240:601158
5727:Types
5483:MAP2K
5417:ACVR1
5410:BMPR2
5395:BMPR1
5320:GSK-3
5161:MAP3K
5122:MAPK9
5117:MAPK8
5095:MAPK7
5090:MAPK6
5085:MAPK4
5080:MAPK3
5075:MAPK1
4987:PFTK1
4982:PCTK3
4977:PCTK2
4972:PCTK1
4962:CDK12
4957:CDK10
4932:CDKL5
4912:CDKL2
4789:STK19
4784:EEF2K
4765:PHKG2
4760:PHKG1
4750:PHKA2
4745:PHKA1
4726:MYLK4
4721:MYLK3
4716:MYLK2
4692:DCLK1
4687:Titin
4677:TRIB3
4672:TRIB2
4667:TRIB1
4657:TSSK2
4637:STK40
4622:PSKH1
4617:PRKD3
4612:PRKD2
4592:PHKG2
4587:PHKG1
4577:OBSCN
4572:NUAK2
4567:NUAK1
4562:MKNK2
4557:MKNK1
4547:MARK4
4542:MARK3
4537:MARK2
4532:MARK1
4512:STK11
4507:DAPK3
4502:DAPK2
4497:DAPK1
4492:CHEK2
4487:CHEK1
4472:CAMK4
4447:CAMK2
4422:CAMK1
4417:BRSK2
4311:PRKCQ
4306:PRKCI
4301:PRKCG
4296:PRKCH
4291:PRKCE
4286:PRKCD
4247:PRKG1
4179:IKBKG
4174:IKBKE
4123:STK10
4118:FASTK
4044:IDH3G
4039:IDH3B
4034:IDH3A
4000:BCKDK
3794:ROCK1
3779:STK38
3774:MAST2
3769:MAST1
3764:LATS2
3759:LATS1
3350:S2CID
3307:S2CID
3109:85220
3060:84763
2975:S2CID
2786:85399
2678:S2CID
2106:23822
1832:S2CID
1633:GSTP1
1627:DUSP1
1609:C-jun
1520:MAPK8
1097:26419
1057:Mouse
1052:Human
1023:Amigo
513:Mouse
506:Human
453:Start
388:Mouse
352:Start
285:Human
264:MAPK8
256:56760
223:MAPK8
24:MAPK8
5819:list
5812:EC7
5806:list
5799:EC6
5793:list
5786:EC5
5780:list
5773:EC4
5767:list
5760:EC3
5754:list
5747:EC2
5741:list
5734:EC1
5310:TPK1
5286:CDC7
5244:MLKs
5237:KSR2
5232:KSR1
5227:BRAF
5222:ARAF
5217:RAFs
4952:CDK9
4947:CDK8
4942:CDK7
4937:CDK6
4927:CDK5
4922:CDK4
4917:CDK3
4907:CDK2
4902:CDK1
4883:PLK4
4878:PLK3
4873:PLK2
4868:PLK1
4823:PLK4
4818:PLK3
4813:PLK2
4808:PLK1
4755:PHKB
4711:MYLK
4682:TRIO
4652:SPEG
4647:SNRK
4607:PKD1
4602:PIM2
4597:PIM1
4582:PASK
4552:MELK
4482:CASK
4477:MLCK
4398:GRK6
4393:GRK5
4388:GRK4
4326:PKN3
4321:PKN2
4223:PRKY
4169:TBK1
4164:IKK2
4159:CHUK
4063:STK4
4029:IDH2
3914:PDK4
3909:PDK3
3904:PDK2
3899:PDK1
3878:WEE1
3873:Wee1
3841:mTOR
3829:AKT3
3824:AKT2
3819:AKT1
3809:SGK3
3804:SGK2
3671:2ok1
3656:2o2u
3641:2o0u
3626:2no3
3611:2h96
3596:2gmx
3581:2g01
3566:2exc
3551:2b1p
3536:1uki
3521:1ukh
3506:1pmv
3491:1pmu
3476:1pmq
3461:1pmn
3446:1jnk
3342:PMID
3299:PMID
3281:Cell
3262:ISBN
3231:PMID
3204:PMID
3155:PMID
3114:PMID
3065:PMID
3016:PMID
2967:PMID
2932:PMID
2891:PMID
2850:PMID
2791:PMID
2737:PMID
2670:PMID
2621:PMID
2580:PMID
2539:PMID
2498:PMID
2457:PMID
2416:PMID
2367:PMID
2331:PMID
2290:PMID
2249:PMID
2208:PMID
2155:PMID
2111:PMID
2045:PMID
2001:PMID
1960:PMID
1881:PMID
1824:PMID
1808:Cell
1704:SPIB
1645:ITCH
1639:IRS1
1537:and
1523:gene
1078:5599
821:axon
496:Bgee
444:Band
405:Chr.
343:Band
302:Chr.
236:OMIM
193:4YR8
189:4UX9
185:4QTD
181:4L7F
177:4IZY
173:4HYU
169:4HYS
165:4G1W
161:4E73
157:4AWI
153:3VUM
149:3VUL
145:3VUK
141:3VUI
137:3VUH
133:3VUG
129:3VUD
125:3V3V
121:3PZE
117:3O2M
113:3O17
109:3ELJ
105:2XS0
101:2XRW
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