486:
463:
2970:
2940:
360:
385:
2985:
3000:
2865:
2850:
2925:
2790:
2835:
2820:
2805:
737:
2775:
2910:
29:
2955:
492:
391:
2895:
2880:
5177:
5197:
1570:
family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs).
55:
2312:
Lannuzel A, Barnier JV, Hery C, Huynh VT, Guibert B, Gray F, Vincent JD, Tardieu M (1997). "Human immunodeficiency virus type 1 and its coat protein gp120 induce apoptosis and activate JNK and ERK mitogen-activated protein kinases in human neurons".
2969:
3040:
1595:
can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
2549:
Lisnock J, Griffin P, Calaycay J, Frantz B, Parsons J, O'Keefe SJ, LoGrasso P (2000). "Activation of JNK3 alpha 1 requires both MKK4 and MKK7: kinetic characterization of in vitro phosphorylated JNK3 alpha 1".
2165:
Jabado N, Pallier A, Jauliac S, Fischer A, Hivroz C (1997). "gp160 of HIV or anti-CD4 monoclonal antibody ligation of CD4 induces inhibition of JNK and ERK-2 activities in human peripheral CD4+ T lymphocytes".
3325:
2939:
2653:
Habelhah H, Shah K, Huang L, Ostareck-Lederer A, Burlingame AL, Shokat KM, Hentze MW, Ronai Z (2001). "ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation".
2984:
2999:
2864:
2849:
2203:
Yang DD, Kuan CY, Whitmarsh AJ, Rincón M, Zheng TS, Davis RJ, Rakic P, Flavell RA (1997). "Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene".
3033:
2924:
2579:
McDonald PH, Chow CW, Miller WE, Laporte SA, Field ME, Lin FT, Davis RJ, Lefkowitz RJ (2000). "Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3".
1758:"Head-to-head juxtaposition of Fas-associated phosphatase-1 (FAP-1) and c-Jun NH2-terminal kinase 3 (JNK3) genes: genomic structure and seven polymorphisms of the FAP-1 gene"
3026:
499:
398:
3233:
2248:
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".
2789:
2834:
2819:
2804:
3781:
4620:
3084:
4729:
3467:
3354:
1085:
321:
3742:
1066:
2774:
4715:
4180:
3071:
3053:
4817:
4698:
1914:"Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade"
5271:
4404:
3273:
2909:
5242:
4468:
3443:
2954:
2754:
1689:
1671:
5261:
4724:
2136:
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".
2422:"A novel Jun N-terminal kinase (JNK)-binding protein that enhances the activation of JNK by MEK kinase 1 and TGF-beta-activated kinase 1"
52:
3258:
485:
4781:
4456:
1488:
2465:"JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway"
1816:"JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway"
1481:
4896:
3713:
3703:
3388:
1587:, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by
462:
4395:
1800:
4664:
4336:
3698:
3689:
1968:
Freedman BD, Liu QH, Del Corno M, Collman RG (2003). "HIV-1 gp120 chemokine receptor-mediated signaling in human macrophages".
1658:
1637:
1814:
Ito M, Yoshioka K, Akechi M, Yamashita S, Takamatsu N, Sugiyama K, Hibi M, Nakabeppu Y, Shiba T, Yamamoto KI (November 1999).
2978:: Crystal structure of human JNK3 complexed with N-{3-cyano-6--4,5,6,7-tetrahydrothienopyridin-2-yl}-1-naphthalenecarboxamide
5052:
1654:
384:
359:
4079:
3576:
3567:
3224:
3170:
2948:: Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide C-jun NH2-terminal Kinase Inhibitors
2048:
Pulverer BJ, Kyriakis JM, Avruch J, Nikolakaki E, Woodgett JR (1991). "Phosphorylation of c-jun mediated by MAP kinases".
5167:
1633:
3267:
301:
1605:
498:
397:
2463:
Ito M, Yoshioka K, Akechi M, Yamashita S, Takamatsu N, Sugiyama K, Hibi M, Nakabeppu Y, Shiba T, Yamamoto KI (1999).
3018:
4291:
4109:
3605:
2993:: Crystal structure of human JNK3 complexed with N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide
491:
390:
5037:
2894:
2879:
5235:
5153:
5140:
5127:
5114:
5101:
5088:
5075:
4281:
4276:
4271:
4261:
4256:
4251:
4241:
4036:
3811:
3407:
2747:
1592:
5047:
5001:
4944:
4504:
4495:
4446:
3212:
3057:
1130:
309:
3008:: Crystal structure of JNK3 bound to N-benzyl-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide
4949:
4804:
4227:
1111:
1588:
4970:
4889:
3503:
5042:
2701:
1912:
Matsuura H, Nishitoh H, Takeda K, Matsuzawa A, Amagasa T, Ito M, Yoshioka K, Ichijo H (October 2002).
5228:
4070:
2740:
2588:
2212:
2057:
1576:
1347:
373:
2873:: Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125
2858:: Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125
288:
5006:
2508:"Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3"
1865:"Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3"
1464:
1460:
1456:
1452:
1448:
1444:
1440:
1436:
1432:
1428:
1424:
1420:
1416:
1412:
1408:
1404:
1400:
1396:
1388:
1378:
1374:
1370:
1366:
1362:
1343:
1339:
1335:
1313:
1309:
1305:
1285:
1281:
1271:
1267:
1263:
1255:
1240:
1236:
1232:
1228:
1224:
1214:
4578:
5266:
4939:
4681:
4635:
2679:
2641:
2451:
2338:
2236:
2191:
2124:
2095:"p493F12 kinase: a novel MAP kinase expressed in a subset of neurons in the human nervous system"
2081:
2036:
1993:
333:
1392:
1331:
1321:
1317:
1259:
1210:
1206:
1202:
1198:
3941:
3650:
2712:
2671:
2633:
2604:
2567:
2537:
2494:
2443:
2408:
2373:
2330:
2300:
2265:
2228:
2183:
2153:
2116:
2073:
2028:
1985:
1945:
1894:
1845:
1779:
1738:
281:
45:
5212:
4985:
4980:
4954:
4882:
4534:
3776:
3766:
3761:
3679:
3670:
3600:
3591:
3537:
3528:
3185:
2663:
2625:
2596:
2559:
2527:
2519:
2484:
2476:
2433:
2398:
2363:
2322:
2290:
2257:
2220:
2175:
2145:
2106:
2065:
2018:
1977:
1935:
1925:
1884:
1876:
1835:
1827:
1769:
1728:
1720:
736:
578:
509:
453:
408:
329:
5032:
5016:
4929:
4360:
3431:
3426:
3421:
2705:
2007:"Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways"
1707:
Gupta S, Barrett T, Whitmarsh AJ, Cavanagh J, Sluss HK, Dérijard B, Davis RJ (July 1996).
1584:
1572:
553:
2933:: Selective Aminopyridine-Based C-Jun N-terminal Kinase inhibitors with cellular activity
2592:
2350:
Xie X, Gu Y, Fox T, Coll JT, Fleming MA, Markland W, Caron PR, Wilson KP, Su MS (1998).
2216:
2061:
28:
5181:
5070:
5011:
1724:
2438:
2421:
2368:
2351:
2261:
1733:
1708:
1000:
995:
990:
985:
980:
975:
970:
965:
960:
955:
950:
945:
940:
935:
930:
925:
920:
915:
910:
905:
889:
884:
879:
874:
869:
864:
859:
854:
849:
844:
839:
823:
818:
813:
808:
803:
798:
793:
788:
783:
778:
5255:
4975:
4934:
3484:
3416:
2721:
2532:
2507:
2489:
2464:
2149:
2111:
2094:
1889:
1864:
1840:
1815:
765:
292:, JNK3, JNK3A, PRKM10, SAPK1b, p493F12, p54bSAPK, mitogen-activated protein kinase 10
2683:
2645:
2523:
2455:
2342:
2195:
2128:
2085:
2040:
1997:
1880:
313:
5208:
4924:
4355:
3180:
2240:
571:
350:
2629:
2600:
1709:"Selective interaction of JNK protein kinase isoforms with transcription factors"
337:
5148:
5083:
4919:
4561:
4193:
4133:
4016:
3936:
3660:
1981:
1694:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1676:
National Center for
Biotechnology Information, U.S. National Library of Medicine
5176:
2385:
Sanger Centre, The; Washington
University Genome Sequencing Cente, The (1998).
1579:, this kinase plays regulatory roles in the signaling pathways during neuronal
654:
4649:
3123:
1567:
470:
367:
317:
2798:: Crystal structure of JNK3 in complex with an imidazole-pyrimidine inhibitor
5122:
5096:
3610:
1580:
1030:
714:
592:
537:
524:
436:
423:
325:
2675:
2637:
2608:
2571:
2541:
2498:
2480:
2447:
2295:
2278:
2179:
2032:
1989:
1949:
1930:
1913:
1898:
1849:
1831:
1783:
1756:
Yoshida S, Harada H, Nagai H, Fukino K, Teramoto A, Emi M (November 2002).
2412:
2377:
2334:
2326:
2304:
2269:
2232:
2187:
2157:
2120:
2077:
1774:
1757:
1742:
1528:
1523:
3966:
3861:
3856:
3851:
2843:: The structure of JNK3 in complex with a dihydroanthrapyrazole inhibitor
2828:: The crystal structure of JNK3 in complex with a phenantroline inhibitor
2813:: The structure of JNK3 in complex with an imidazole-pyrimidine inhibitor
2616:
Pouysségur J (2000). "Signal transduction. An arresting start for MAPK".
2403:
2386:
1609:
1512:
1179:
1160:
1156:
2023:
2006:
4625:
4603:
4598:
4588:
4583:
4385:
4380:
4375:
4370:
4365:
4350:
4345:
3996:
3961:
3200:
3195:
3190:
2726:
2716:
1142:
1097:
2420:
Koyano S, Ito M, Takamatsu N, Shiba T, Yamamoto K, Yoshioka K (1999).
2352:"Crystal structure of JNK3: a kinase implicated in neuronal apoptosis"
258:
254:
250:
246:
242:
238:
234:
230:
226:
222:
218:
214:
210:
206:
202:
198:
194:
190:
186:
182:
178:
174:
170:
166:
162:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
114:
110:
106:
102:
98:
94:
90:
86:
82:
78:
74:
5135:
4905:
4855:
4850:
4845:
4840:
4835:
4830:
4825:
4776:
4771:
4766:
4761:
4756:
4739:
4734:
4608:
4593:
4544:
4539:
4524:
4519:
4514:
4509:
4483:
4478:
4473:
4439:
4434:
4326:
4301:
3976:
3801:
3796:
3791:
3786:
3771:
3615:
3552:
3547:
3542:
3518:
3344:
3339:
3313:
3308:
3303:
3293:
3288:
3278:
3118:
3049:
2667:
2563:
2069:
1940:
1548:
1496:
1052:
5196:
5109:
4751:
4744:
4654:
4551:
4451:
4429:
4424:
4419:
4414:
4409:
4321:
4316:
4311:
4306:
4296:
4266:
4246:
4123:
4118:
4099:
4094:
4084:
4060:
4055:
4050:
4026:
4021:
4011:
4006:
4001:
3991:
3971:
3956:
3951:
3946:
3926:
3921:
3911:
3906:
3901:
3896:
3891:
3881:
3876:
3871:
3866:
3846:
3841:
3836:
3831:
3826:
3821:
3806:
3756:
3751:
3645:
3640:
3635:
3630:
3625:
3620:
3581:
3513:
3508:
3457:
3452:
3378:
3373:
3368:
3334:
3326:
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase
3128:
3113:
3108:
3103:
3098:
3093:
2224:
2005:
Lee C, Liu QH, Tomkowicz B, Yi Y, Freedman BD, Collman RG (2003).
1015:
1011:
5204:
4644:
4571:
4566:
4556:
4529:
4286:
4236:
4217:
4212:
4207:
4202:
4157:
4152:
4147:
4142:
4089:
4045:
3986:
3981:
3931:
3916:
3886:
3816:
3732:
3727:
3722:
3655:
3557:
3498:
3493:
3397:
3363:
3248:
3243:
3238:
3207:
3175:
3163:
3158:
3153:
3143:
3138:
1555:
305:
4878:
4802:
4178:
3069:
3022:
2736:
745:
4613:
3148:
3133:
2783:: THE C-JUN N-TERMINAL KINASE (JNK3S) COMPLEXED WITH MGAMP-PNP
2732:
2711:
Overview of all the structural information available in the
986:
neurotransmitter receptor transport to postsynaptic membrane
2698:
4874:
2279:"JNK1, JNK2 and JNK3 are p53 N-terminal serine 34 kinases"
1801:"Entrez Gene: MAPK10 mitogen-activated protein kinase 10"
971:
negative regulation of transcription by RNA polymerase II
2918:: Pyrazoloquinolones as Novel, Selective JNK1 inhibitors
1863:
Kelkar N, Gupta S, Dickens M, Davis RJ (February 2000).
561:
5216:
996:
regulation of DNA-binding transcription factor activity
2963:: Novel 4-anilinopyrimidines as potent JNK1 Inhibitors
5165:
726:
1566:
The protein encoded by this gene is a member of the
5061:
5025:
4994:
4963:
4912:
4816:
4714:
4697:
4680:
4663:
4634:
4494:
4394:
4335:
4226:
4192:
4132:
4108:
4069:
4035:
3741:
3712:
3688:
3669:
3590:
3566:
3527:
3483:
3466:
3442:
3406:
3387:
3353:
3324:
3257:
3223:
3083:
1361:
1304:
1254:
1197:
1650:
1648:
1646:
1629:
1627:
1625:
508:
407:
2506:Kelkar N, Gupta S, Dickens M, Davis RJ (2000).
16:Protein-coding gene in the species Homo sapiens
1655:GRCm38: Ensembl release 89: ENSMUSG00000046709
5236:
4890:
3085:Non-specific serine/threonine protein kinases
3034:
2748:
2725:(Mitogen-activated protein kinase 10) at the
8:
1634:GRCh38: Ensembl release 89: ENSG00000109339
5243:
5229:
4897:
4883:
4875:
4813:
4799:
4189:
4175:
3468:Goodpasture-antigen-binding protein kinase
3080:
3066:
3041:
3027:
3019:
2755:
2741:
2733:
1358:
1301:
1251:
1194:
1026:
761:
549:
448:
345:
63:
4181:Serine/threonine-specific protein kinases
3355:(isocitrate dehydrogenase (NADP+)) kinase
3072:Serine/threonine-specific protein kinases
3054:Serine/threonine-specific protein kinases
2531:
2488:
2437:
2402:
2387:"Toward a complete human genome sequence"
2367:
2294:
2110:
2022:
1939:
1929:
1888:
1839:
1773:
1732:
4716:Receptor protein serine/threonine kinase
1795:
1793:
804:protein serine/threonine kinase activity
5172:
4699:Low-density-lipoprotein receptor kinase
2770:
2093:Mohit AA, Martin JH, Miller CA (1995).
1621:
966:cellular response to organic substance
18:
3444:Fas-activated serine/threonine kinase
991:vesicle-mediated transport in synapse
921:Fc-epsilon receptor signaling pathway
513:
474:
469:
412:
371:
366:
7:
5193:
5191:
4725:Bone morphogenetic protein receptors
3259:Dephospho-(reductase kinase) kinase
1541:Mitogen-activated protein kinase 10
5215:. You can help Knowledge (XXG) by
3714:G-protein coupled receptor kinases
1725:10.1002/j.1460-2075.1996.tb00636.x
1170:
1147:
1121:
1102:
1076:
1057:
890:intracellular anatomical structure
731:
649:
587:
566:
14:
3704:Beta adrenergic receptor kinase-2
3389:(tyrosine 3-monooxygenase) kinase
1551:that in humans is encoded by the
961:intracellular signal transduction
5195:
5175:
4396:Mitogen-activated protein kinase
2998:
2983:
2968:
2953:
2938:
2923:
2908:
2893:
2878:
2863:
2848:
2833:
2818:
2803:
2788:
2773:
735:
497:
490:
484:
461:
396:
389:
383:
358:
27:
4782:Anti-Müllerian hormone receptor
4665:(acetyl-CoA carboxylase) kinase
4337:(RNA-polymerase)-subunit kinase
3699:Beta adrenergic receptor kinase
3690:Beta adrenergic receptor kinase
2524:10.1128/MCB.20.3.1030-1043.2000
2277:Hu MC, Qiu WR, Wang YP (1997).
1881:10.1128/MCB.20.3.1030-1043.2000
4405:Extracellular signal-regulated
981:cellular hyperosmotic response
931:regulation of circadian rhythm
746:More reference expression data
715:More reference expression data
1:
5272:Human chromosome 4 gene stubs
4469:P38 mitogen-activated protein
3568:cGMP-dependent protein kinase
3529:cAMP-dependent protein kinase
3225:Pyruvate dehydrogenase kinase
3171:Ataxia telangiectasia mutated
2630:10.1126/science.290.5496.1515
2601:10.1126/science.290.5496.1574
2439:10.1016/S0014-5793(99)01084-4
2369:10.1016/S0969-2126(98)00100-2
2262:10.1016/S0378-1119(97)00411-3
976:response to water deprivation
951:regulation of gene expression
482:
381:
3268:AMP-activated protein kinase
2150:10.1016/0378-1119(94)90802-8
2112:10.1016/0896-6273(95)90241-4
5262:Genes on human chromosome 4
4183:(EC 2.7.11.21-EC 2.7.11.30)
2903:: Inhibitor complex of JNK3
2888:: inhibitor complex of JNK3
5288:
5190:
4110:Elongation factor 2 kinase
3074:(EC 2.7.11.1-EC 2.7.11.20)
911:response to light stimulus
819:MAP kinase kinase activity
5053:Michaelis–Menten kinetics
4812:
4798:
4505:MAP kinase kinase kinases
4188:
4174:
4037:Myosin light-chain kinase
3743:Ca2+/calmodulin-dependent
3408:Myosin-heavy-chain kinase
3079:
3065:
2768:
1690:"Mouse PubMed Reference:"
1672:"Human PubMed Reference:"
1604:MAPK10 has been shown to
1593:Cyclin-dependent kinase 5
1545:c-Jun N-terminal kinase 3
1527:
1522:
1518:
1511:
1495:
1489:Chr 5: 103.06 – 103.36 Mb
1476:
1385:
1328:
1297:
1278:
1221:
1190:
1177:
1173:
1154:
1150:
1141:
1128:
1124:
1109:
1105:
1096:
1083:
1079:
1064:
1060:
1051:
1036:
1029:
1025:
1009:
764:
760:
743:
734:
725:
712:
685:medial geniculate nucleus
673:medial vestibular nucleus
661:
652:
631:anterior cingulate cortex
599:
590:
560:
552:
548:
531:
518:
481:
460:
451:
447:
430:
417:
380:
357:
348:
344:
299:
296:
286:
279:
274:
71:
66:
49:
44:
39:
35:
26:
21:
4945:Diffusion-limited enzyme
4805:Dual-specificity kinases
677:anterior amygdaloid area
4228:Cyclin-dependent kinase
1482:Chr 4: 85.99 – 86.59 Mb
926:protein phosphorylation
789:protein kinase activity
2481:10.1128/mcb.19.11.7539
2296:10.1038/sj.onc.1201401
2180:10.1002/eji.1830270209
1931:10.1074/jbc.M202004200
1832:10.1128/mcb.19.11.7539
5038:Eadie–Hofstee diagram
4971:Allosteric regulation
2327:10.1002/ana.410420605
1982:10.1385/IR:27:2-3:261
1775:10.1007/s100380200094
885:glutamatergic synapse
693:medial dorsal nucleus
619:middle temporal gyrus
615:primary visual cortex
5048:Lineweaver–Burk plot
4071:Phosphorylase kinase
2699:MAP Kinase Resource
2404:10.1101/gr.8.11.1097
1577:nuclear localization
779:transferase activity
697:primary motor cortex
476:Chromosome 5 (mouse)
374:Chromosome 4 (human)
67:List of PDB id codes
40:Available structures
2593:2000Sci...290.1574M
2217:1997Natur.389..865Y
2062:1991Natur.353..670P
2024:10.1189/jlb.0503206
1589:MAP kinase kinase 4
941:JUN phosphorylation
936:signal transduction
824:JUN kinase activity
794:MAP kinase activity
5203:This article on a
5007:Enzyme superfamily
4940:Enzyme promiscuity
4682:Tropomyosin kinase
4636:Tau-protein kinase
2704:2021-04-15 at the
1131:ENSMUSG00000046709
956:neuron development
899:Biological process
833:Cellular component
784:nucleotide binding
772:Molecular function
607:right frontal lobe
338:MAPK10 - orthologs
5224:
5223:
5163:
5162:
4872:
4871:
4868:
4867:
4864:
4863:
4794:
4793:
4790:
4789:
4170:
4169:
4166:
4165:
3651:Protein kinase N1
3606:Protein kinase Cζ
3016:
3015:
1538:
1537:
1534:
1533:
1507:
1506:
1472:
1471:
1355:
1354:
1293:
1292:
1248:
1247:
1186:
1185:
1167:
1166:
1137:
1136:
1118:
1117:
1092:
1091:
1073:
1072:
1021:
1020:
870:neuron projection
756:
755:
752:
751:
721:
720:
708:
707:
689:prefrontal cortex
646:
645:
603:prefrontal cortex
544:
543:
443:
442:
270:
269:
266:
265:
50:Ortholog search:
5279:
5245:
5238:
5231:
5199:
5192:
5180:
5179:
5171:
5043:Hanes–Woolf plot
4986:Enzyme activator
4981:Enzyme inhibitor
4955:Enzyme catalysis
4899:
4892:
4885:
4876:
4814:
4800:
4447:C-Jun N-terminal
4190:
4176:
3680:Rhodopsin kinase
3671:Rhodopsin kinase
3601:Protein kinase C
3592:Protein kinase C
3577:Protein kinase G
3538:Protein kinase A
3149:Protein kinase B
3081:
3067:
3043:
3036:
3029:
3020:
3002:
2987:
2972:
2957:
2942:
2927:
2912:
2897:
2882:
2867:
2852:
2837:
2822:
2807:
2792:
2777:
2757:
2750:
2743:
2734:
2687:
2668:10.1038/35060131
2649:
2624:(5496): 1515–8.
2612:
2587:(5496): 1574–7.
2575:
2564:10.1021/bi992410
2545:
2535:
2502:
2492:
2459:
2441:
2416:
2406:
2397:(11): 1097–108.
2381:
2371:
2346:
2308:
2298:
2273:
2244:
2211:(6653): 865–70.
2199:
2161:
2132:
2114:
2089:
2070:10.1038/353670a0
2044:
2026:
2001:
1954:
1953:
1943:
1933:
1909:
1903:
1902:
1892:
1860:
1854:
1853:
1843:
1811:
1805:
1804:
1797:
1788:
1787:
1777:
1753:
1747:
1746:
1736:
1704:
1698:
1697:
1686:
1680:
1679:
1668:
1662:
1652:
1641:
1631:
1520:
1519:
1491:
1484:
1467:
1359:
1350:
1302:
1298:RefSeq (protein)
1288:
1252:
1243:
1195:
1171:
1148:
1122:
1103:
1077:
1058:
1027:
916:rhythmic process
762:
748:
739:
732:
717:
665:substantia nigra
657:
655:Top expressed in
650:
635:endothelial cell
623:Brodmann area 23
595:
593:Top expressed in
588:
567:
550:
540:
527:
516:
501:
494:
488:
477:
465:
449:
439:
426:
415:
400:
393:
387:
376:
362:
346:
340:
291:
284:
261:
64:
58:
37:
36:
31:
19:
5287:
5286:
5282:
5281:
5280:
5278:
5277:
5276:
5252:
5251:
5250:
5249:
5188:
5186:
5174:
5166:
5164:
5159:
5071:Oxidoreductases
5057:
5033:Enzyme kinetics
5021:
5017:List of enzymes
4990:
4959:
4930:Catalytic triad
4908:
4903:
4873:
4860:
4808:
4786:
4710:
4693:
4676:
4659:
4630:
4490:
4390:
4361:P70-S6 Kinase 1
4331:
4222:
4184:
4162:
4128:
4104:
4065:
4031:
3737:
3708:
3684:
3665:
3586:
3562:
3523:
3479:
3462:
3438:
3432:Aurora C kinase
3427:Aurora B kinase
3422:Aurora A kinase
3402:
3383:
3349:
3320:
3253:
3219:
3075:
3061:
3047:
3017:
3012:
3009:
3003:
2994:
2988:
2979:
2973:
2964:
2958:
2949:
2943:
2934:
2928:
2919:
2913:
2904:
2898:
2889:
2883:
2874:
2868:
2859:
2853:
2844:
2838:
2829:
2823:
2814:
2808:
2799:
2793:
2784:
2778:
2764:
2761:
2706:Wayback Machine
2695:
2690:
2652:
2615:
2578:
2548:
2512:Mol. Cell. Biol
2505:
2475:(11): 7539–48.
2469:Mol. Cell. Biol
2462:
2419:
2384:
2349:
2311:
2289:(19): 2277–87.
2276:
2256:(1–2): 149–56.
2247:
2202:
2168:Eur. J. Immunol
2164:
2135:
2092:
2056:(6345): 670–4.
2047:
2011:J. Leukoc. Biol
2004:
1976:(2–3): 261–76.
1967:
1963:
1961:Further reading
1958:
1957:
1924:(43): 40703–9.
1911:
1910:
1906:
1869:Mol. Cell. Biol
1862:
1861:
1857:
1826:(11): 7539–48.
1820:Mol. Cell. Biol
1813:
1812:
1808:
1799:
1798:
1791:
1755:
1754:
1750:
1719:(11): 2760–70.
1706:
1705:
1701:
1688:
1687:
1683:
1670:
1669:
1665:
1653:
1644:
1632:
1623:
1618:
1602:
1585:Beta-arrestin 2
1573:phosphorylation
1564:
1529:View/Edit Mouse
1524:View/Edit Human
1487:
1480:
1477:Location (UCSC)
1463:
1459:
1455:
1451:
1447:
1443:
1439:
1435:
1431:
1427:
1423:
1419:
1415:
1411:
1407:
1403:
1399:
1395:
1391:
1387:
1381:
1377:
1373:
1369:
1365:
1346:
1342:
1338:
1334:
1330:
1324:
1320:
1316:
1312:
1308:
1284:
1280:
1274:
1270:
1266:
1262:
1258:
1239:
1235:
1231:
1227:
1223:
1217:
1213:
1209:
1205:
1201:
1159:
1112:ENSG00000109339
1005:
906:phosphorylation
894:
855:plasma membrane
828:
809:protein binding
799:kinase activity
744:
713:
704:
701:mammillary body
699:
695:
691:
687:
683:
679:
675:
671:
667:
653:
642:
637:
633:
629:
627:cingulate gyrus
625:
621:
617:
613:
611:Brodmann area 9
609:
605:
591:
535:
522:
514:
504:
503:
502:
495:
475:
452:Gene location (
434:
421:
413:
403:
402:
401:
394:
372:
349:Gene location (
300:
287:
280:
73:
51:
17:
12:
11:
5:
5285:
5283:
5275:
5274:
5269:
5264:
5254:
5253:
5248:
5247:
5240:
5233:
5225:
5222:
5221:
5200:
5185:
5184:
5161:
5160:
5158:
5157:
5144:
5131:
5118:
5105:
5092:
5079:
5065:
5063:
5059:
5058:
5056:
5055:
5050:
5045:
5040:
5035:
5029:
5027:
5023:
5022:
5020:
5019:
5014:
5009:
5004:
4998:
4996:
4995:Classification
4992:
4991:
4989:
4988:
4983:
4978:
4973:
4967:
4965:
4961:
4960:
4958:
4957:
4952:
4947:
4942:
4937:
4932:
4927:
4922:
4916:
4914:
4910:
4909:
4904:
4902:
4901:
4894:
4887:
4879:
4870:
4869:
4866:
4865:
4862:
4861:
4859:
4858:
4853:
4848:
4843:
4838:
4833:
4828:
4822:
4820:
4810:
4809:
4803:
4796:
4795:
4792:
4791:
4788:
4787:
4785:
4784:
4779:
4774:
4769:
4764:
4759:
4754:
4749:
4748:
4747:
4742:
4737:
4732:
4721:
4719:
4718:(EC 2.7.11.30)
4712:
4711:
4709:
4708:
4704:
4702:
4701:(EC 2.7.11.29)
4695:
4694:
4692:
4691:
4687:
4685:
4684:(EC 2.7.11.28)
4678:
4677:
4675:
4674:
4670:
4668:
4667:(EC 2.7.11.27)
4661:
4660:
4658:
4657:
4652:
4647:
4641:
4639:
4638:(EC 2.7.11.26)
4632:
4631:
4629:
4628:
4623:
4618:
4617:
4616:
4611:
4606:
4601:
4596:
4591:
4586:
4576:
4575:
4574:
4569:
4564:
4559:
4549:
4548:
4547:
4542:
4537:
4532:
4527:
4522:
4517:
4512:
4501:
4499:
4498:(EC 2.7.11.25)
4492:
4491:
4489:
4488:
4487:
4486:
4481:
4476:
4466:
4465:
4464:
4459:
4454:
4444:
4443:
4442:
4437:
4432:
4427:
4422:
4417:
4412:
4401:
4399:
4398:(EC 2.7.11.24)
4392:
4391:
4389:
4388:
4383:
4378:
4373:
4368:
4363:
4358:
4353:
4348:
4342:
4340:
4339:(EC 2.7.11.23)
4333:
4332:
4330:
4329:
4324:
4319:
4314:
4309:
4304:
4299:
4294:
4289:
4284:
4279:
4274:
4269:
4264:
4259:
4254:
4249:
4244:
4239:
4233:
4231:
4230:(EC 2.7.11.22)
4224:
4223:
4221:
4220:
4215:
4210:
4205:
4199:
4197:
4196:(EC 2.7.11.21)
4186:
4185:
4179:
4172:
4171:
4168:
4167:
4164:
4163:
4161:
4160:
4155:
4150:
4145:
4139:
4137:
4136:(EC 2.7.11.21)
4130:
4129:
4127:
4126:
4121:
4115:
4113:
4112:(EC 2.7.11.20)
4106:
4105:
4103:
4102:
4097:
4092:
4087:
4082:
4076:
4074:
4073:(EC 2.7.11.19)
4067:
4066:
4064:
4063:
4058:
4053:
4048:
4042:
4040:
4039:(EC 2.7.11.18)
4033:
4032:
4030:
4029:
4024:
4019:
4014:
4009:
4004:
3999:
3994:
3989:
3984:
3979:
3974:
3969:
3964:
3959:
3954:
3949:
3944:
3939:
3934:
3929:
3924:
3919:
3914:
3909:
3904:
3899:
3894:
3889:
3884:
3879:
3874:
3869:
3864:
3859:
3854:
3849:
3844:
3839:
3834:
3829:
3824:
3819:
3814:
3809:
3804:
3799:
3794:
3789:
3784:
3779:
3774:
3769:
3764:
3759:
3754:
3748:
3746:
3745:(EC 2.7.11.17)
3739:
3738:
3736:
3735:
3730:
3725:
3719:
3717:
3716:(EC 2.7.11.16)
3710:
3709:
3707:
3706:
3701:
3695:
3693:
3692:(EC 2.7.11.15)
3686:
3685:
3683:
3682:
3676:
3674:
3673:(EC 2.7.11.14)
3667:
3666:
3664:
3663:
3658:
3653:
3648:
3643:
3638:
3633:
3628:
3623:
3618:
3613:
3608:
3603:
3597:
3595:
3594:(EC 2.7.11.13)
3588:
3587:
3585:
3584:
3579:
3573:
3571:
3570:(EC 2.7.11.12)
3564:
3563:
3561:
3560:
3555:
3550:
3545:
3540:
3534:
3532:
3531:(EC 2.7.11.11)
3525:
3524:
3522:
3521:
3516:
3511:
3506:
3501:
3496:
3490:
3488:
3487:(EC 2.7.11.10)
3481:
3480:
3478:
3477:
3473:
3471:
3464:
3463:
3461:
3460:
3455:
3449:
3447:
3440:
3439:
3437:
3436:
3435:
3434:
3429:
3424:
3413:
3411:
3404:
3403:
3401:
3400:
3394:
3392:
3385:
3384:
3382:
3381:
3376:
3371:
3366:
3360:
3358:
3351:
3350:
3348:
3347:
3342:
3337:
3331:
3329:
3322:
3321:
3319:
3318:
3317:
3316:
3311:
3306:
3298:
3297:
3296:
3291:
3283:
3282:
3281:
3276:
3264:
3262:
3255:
3254:
3252:
3251:
3246:
3241:
3236:
3230:
3228:
3221:
3220:
3218:
3217:
3216:
3215:
3205:
3204:
3203:
3198:
3193:
3188:
3178:
3173:
3168:
3167:
3166:
3161:
3156:
3146:
3141:
3136:
3131:
3126:
3121:
3116:
3111:
3106:
3101:
3096:
3090:
3088:
3077:
3076:
3070:
3063:
3062:
3048:
3046:
3045:
3038:
3031:
3023:
3014:
3013:
3011:
3010:
3004:
2997:
2995:
2989:
2982:
2980:
2974:
2967:
2965:
2959:
2952:
2950:
2944:
2937:
2935:
2929:
2922:
2920:
2914:
2907:
2905:
2899:
2892:
2890:
2884:
2877:
2875:
2869:
2862:
2860:
2854:
2847:
2845:
2839:
2832:
2830:
2824:
2817:
2815:
2809:
2802:
2800:
2794:
2787:
2785:
2779:
2772:
2769:
2766:
2765:
2762:
2760:
2759:
2752:
2745:
2737:
2731:
2730:
2709:
2694:
2693:External links
2691:
2689:
2688:
2656:Nat. Cell Biol
2650:
2613:
2576:
2558:(11): 3141–8.
2546:
2518:(3): 1030–43.
2503:
2460:
2417:
2382:
2347:
2309:
2274:
2245:
2200:
2174:(2): 397–404.
2162:
2144:(1–2): 171–4.
2133:
2090:
2045:
2002:
1964:
1962:
1959:
1956:
1955:
1904:
1875:(3): 1030–43.
1855:
1806:
1789:
1748:
1699:
1681:
1663:
1642:
1620:
1619:
1617:
1614:
1601:
1598:
1563:
1560:
1543:also known as
1536:
1535:
1532:
1531:
1526:
1516:
1515:
1509:
1508:
1505:
1504:
1502:
1500:
1493:
1492:
1485:
1478:
1474:
1473:
1470:
1469:
1383:
1382:
1356:
1353:
1352:
1348:NP_001304997.1
1326:
1325:
1299:
1295:
1294:
1291:
1290:
1276:
1275:
1249:
1246:
1245:
1219:
1218:
1192:
1188:
1187:
1184:
1183:
1175:
1174:
1168:
1165:
1164:
1152:
1151:
1145:
1139:
1138:
1135:
1134:
1126:
1125:
1119:
1116:
1115:
1107:
1106:
1100:
1094:
1093:
1090:
1089:
1081:
1080:
1074:
1071:
1070:
1062:
1061:
1055:
1049:
1048:
1043:
1038:
1034:
1033:
1023:
1022:
1019:
1018:
1007:
1006:
1004:
1003:
998:
993:
988:
983:
978:
973:
968:
963:
958:
953:
948:
943:
938:
933:
928:
923:
918:
913:
908:
902:
900:
896:
895:
893:
892:
887:
882:
877:
872:
867:
862:
857:
852:
847:
842:
836:
834:
830:
829:
827:
826:
821:
816:
811:
806:
801:
796:
791:
786:
781:
775:
773:
769:
768:
758:
757:
754:
753:
750:
749:
741:
740:
729:
723:
722:
719:
718:
710:
709:
706:
705:
703:
702:
698:
694:
690:
686:
682:
678:
674:
670:
666:
662:
659:
658:
647:
644:
643:
641:
640:
636:
632:
628:
624:
620:
616:
612:
608:
604:
600:
597:
596:
584:
583:
575:
564:
558:
557:
554:RNA expression
546:
545:
542:
541:
533:
529:
528:
520:
517:
512:
506:
505:
496:
489:
483:
479:
478:
473:
467:
466:
458:
457:
445:
444:
441:
440:
432:
428:
427:
419:
416:
411:
405:
404:
395:
388:
382:
378:
377:
370:
364:
363:
355:
354:
342:
341:
298:
294:
293:
285:
277:
276:
272:
271:
268:
267:
264:
263:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
5284:
5273:
5270:
5268:
5265:
5263:
5260:
5259:
5257:
5246:
5241:
5239:
5234:
5232:
5227:
5226:
5220:
5218:
5214:
5210:
5206:
5201:
5198:
5194:
5189:
5183:
5178:
5173:
5169:
5155:
5151:
5150:
5145:
5142:
5138:
5137:
5132:
5129:
5125:
5124:
5119:
5116:
5112:
5111:
5106:
5103:
5099:
5098:
5093:
5090:
5086:
5085:
5080:
5077:
5073:
5072:
5067:
5066:
5064:
5060:
5054:
5051:
5049:
5046:
5044:
5041:
5039:
5036:
5034:
5031:
5030:
5028:
5024:
5018:
5015:
5013:
5012:Enzyme family
5010:
5008:
5005:
5003:
5000:
4999:
4997:
4993:
4987:
4984:
4982:
4979:
4977:
4976:Cooperativity
4974:
4972:
4969:
4968:
4966:
4962:
4956:
4953:
4951:
4948:
4946:
4943:
4941:
4938:
4936:
4935:Oxyanion hole
4933:
4931:
4928:
4926:
4923:
4921:
4918:
4917:
4915:
4911:
4907:
4900:
4895:
4893:
4888:
4886:
4881:
4880:
4877:
4857:
4854:
4852:
4849:
4847:
4844:
4842:
4839:
4837:
4834:
4832:
4829:
4827:
4824:
4823:
4821:
4819:
4815:
4811:
4806:
4801:
4797:
4783:
4780:
4778:
4775:
4773:
4770:
4768:
4765:
4763:
4760:
4758:
4755:
4753:
4750:
4746:
4743:
4741:
4738:
4736:
4733:
4731:
4728:
4727:
4726:
4723:
4722:
4720:
4717:
4713:
4706:
4705:
4703:
4700:
4696:
4689:
4688:
4686:
4683:
4679:
4672:
4671:
4669:
4666:
4662:
4656:
4653:
4651:
4648:
4646:
4643:
4642:
4640:
4637:
4633:
4627:
4624:
4622:
4619:
4615:
4612:
4610:
4607:
4605:
4602:
4600:
4597:
4595:
4592:
4590:
4587:
4585:
4582:
4581:
4580:
4577:
4573:
4570:
4568:
4565:
4563:
4560:
4558:
4555:
4554:
4553:
4550:
4546:
4543:
4541:
4538:
4536:
4533:
4531:
4528:
4526:
4523:
4521:
4518:
4516:
4513:
4511:
4508:
4507:
4506:
4503:
4502:
4500:
4497:
4493:
4485:
4482:
4480:
4477:
4475:
4472:
4471:
4470:
4467:
4463:
4460:
4458:
4455:
4453:
4450:
4449:
4448:
4445:
4441:
4438:
4436:
4433:
4431:
4428:
4426:
4423:
4421:
4418:
4416:
4413:
4411:
4408:
4407:
4406:
4403:
4402:
4400:
4397:
4393:
4387:
4384:
4382:
4379:
4377:
4374:
4372:
4369:
4367:
4364:
4362:
4359:
4357:
4354:
4352:
4349:
4347:
4344:
4343:
4341:
4338:
4334:
4328:
4325:
4323:
4320:
4318:
4315:
4313:
4310:
4308:
4305:
4303:
4300:
4298:
4295:
4293:
4290:
4288:
4285:
4283:
4280:
4278:
4275:
4273:
4270:
4268:
4265:
4263:
4260:
4258:
4255:
4253:
4250:
4248:
4245:
4243:
4240:
4238:
4235:
4234:
4232:
4229:
4225:
4219:
4216:
4214:
4211:
4209:
4206:
4204:
4201:
4200:
4198:
4195:
4191:
4187:
4182:
4177:
4173:
4159:
4156:
4154:
4151:
4149:
4146:
4144:
4141:
4140:
4138:
4135:
4131:
4125:
4122:
4120:
4117:
4116:
4114:
4111:
4107:
4101:
4098:
4096:
4093:
4091:
4088:
4086:
4083:
4081:
4078:
4077:
4075:
4072:
4068:
4062:
4059:
4057:
4054:
4052:
4049:
4047:
4044:
4043:
4041:
4038:
4034:
4028:
4025:
4023:
4020:
4018:
4015:
4013:
4010:
4008:
4005:
4003:
4000:
3998:
3995:
3993:
3990:
3988:
3985:
3983:
3980:
3978:
3975:
3973:
3970:
3968:
3965:
3963:
3960:
3958:
3955:
3953:
3950:
3948:
3945:
3943:
3940:
3938:
3935:
3933:
3930:
3928:
3925:
3923:
3920:
3918:
3915:
3913:
3910:
3908:
3905:
3903:
3900:
3898:
3895:
3893:
3890:
3888:
3885:
3883:
3880:
3878:
3875:
3873:
3870:
3868:
3865:
3863:
3860:
3858:
3855:
3853:
3850:
3848:
3845:
3843:
3840:
3838:
3835:
3833:
3830:
3828:
3825:
3823:
3820:
3818:
3815:
3813:
3810:
3808:
3805:
3803:
3800:
3798:
3795:
3793:
3790:
3788:
3785:
3783:
3780:
3778:
3775:
3773:
3770:
3768:
3765:
3763:
3760:
3758:
3755:
3753:
3750:
3749:
3747:
3744:
3740:
3734:
3731:
3729:
3726:
3724:
3721:
3720:
3718:
3715:
3711:
3705:
3702:
3700:
3697:
3696:
3694:
3691:
3687:
3681:
3678:
3677:
3675:
3672:
3668:
3662:
3659:
3657:
3654:
3652:
3649:
3647:
3644:
3642:
3639:
3637:
3634:
3632:
3629:
3627:
3624:
3622:
3619:
3617:
3614:
3612:
3609:
3607:
3604:
3602:
3599:
3598:
3596:
3593:
3589:
3583:
3580:
3578:
3575:
3574:
3572:
3569:
3565:
3559:
3556:
3554:
3551:
3549:
3546:
3544:
3541:
3539:
3536:
3535:
3533:
3530:
3526:
3520:
3517:
3515:
3512:
3510:
3507:
3505:
3502:
3500:
3497:
3495:
3492:
3491:
3489:
3486:
3482:
3475:
3474:
3472:
3470:(EC 2.7.11.9)
3469:
3465:
3459:
3456:
3454:
3451:
3450:
3448:
3446:(EC 2.7.11.8)
3445:
3441:
3433:
3430:
3428:
3425:
3423:
3420:
3419:
3418:
3417:Aurora kinase
3415:
3414:
3412:
3410:(EC 2.7.11.7)
3409:
3405:
3399:
3396:
3395:
3393:
3391:(EC 2.7.11.6)
3390:
3386:
3380:
3377:
3375:
3372:
3370:
3367:
3365:
3362:
3361:
3359:
3357:(EC 2.7.11.5)
3356:
3352:
3346:
3343:
3341:
3338:
3336:
3333:
3332:
3330:
3328:(EC 2.7.11.4)
3327:
3323:
3315:
3312:
3310:
3307:
3305:
3302:
3301:
3299:
3295:
3292:
3290:
3287:
3286:
3284:
3280:
3277:
3275:
3272:
3271:
3269:
3266:
3265:
3263:
3261:(EC 2.7.11.3)
3260:
3256:
3250:
3247:
3245:
3242:
3240:
3237:
3235:
3232:
3231:
3229:
3227:(EC 2.7.11.2)
3226:
3222:
3214:
3211:
3210:
3209:
3206:
3202:
3199:
3197:
3194:
3192:
3189:
3187:
3184:
3183:
3182:
3181:EIF-2 kinases
3179:
3177:
3174:
3172:
3169:
3165:
3162:
3160:
3157:
3155:
3152:
3151:
3150:
3147:
3145:
3142:
3140:
3137:
3135:
3132:
3130:
3127:
3125:
3122:
3120:
3117:
3115:
3112:
3110:
3107:
3105:
3102:
3100:
3097:
3095:
3092:
3091:
3089:
3087:(EC 2.7.11.1)
3086:
3082:
3078:
3073:
3068:
3064:
3059:
3055:
3051:
3044:
3039:
3037:
3032:
3030:
3025:
3024:
3021:
3007:
3001:
2996:
2992:
2986:
2981:
2977:
2971:
2966:
2962:
2956:
2951:
2947:
2941:
2936:
2932:
2926:
2921:
2917:
2911:
2906:
2902:
2896:
2891:
2887:
2881:
2876:
2872:
2866:
2861:
2857:
2851:
2846:
2842:
2836:
2831:
2827:
2821:
2816:
2812:
2806:
2801:
2797:
2791:
2786:
2782:
2776:
2771:
2767:
2758:
2753:
2751:
2746:
2744:
2739:
2738:
2735:
2728:
2724:
2723:
2718:
2714:
2710:
2707:
2703:
2700:
2697:
2696:
2692:
2685:
2681:
2677:
2673:
2669:
2665:
2662:(3): 325–30.
2661:
2657:
2651:
2647:
2643:
2639:
2635:
2631:
2627:
2623:
2619:
2614:
2610:
2606:
2602:
2598:
2594:
2590:
2586:
2582:
2577:
2573:
2569:
2565:
2561:
2557:
2553:
2547:
2543:
2539:
2534:
2529:
2525:
2521:
2517:
2513:
2509:
2504:
2500:
2496:
2491:
2486:
2482:
2478:
2474:
2470:
2466:
2461:
2457:
2453:
2449:
2445:
2440:
2435:
2431:
2427:
2423:
2418:
2414:
2410:
2405:
2400:
2396:
2392:
2388:
2383:
2379:
2375:
2370:
2365:
2362:(8): 983–91.
2361:
2357:
2353:
2348:
2344:
2340:
2336:
2332:
2328:
2324:
2321:(6): 847–56.
2320:
2316:
2310:
2306:
2302:
2297:
2292:
2288:
2284:
2280:
2275:
2271:
2267:
2263:
2259:
2255:
2251:
2246:
2242:
2238:
2234:
2230:
2226:
2225:10.1038/39899
2222:
2218:
2214:
2210:
2206:
2201:
2197:
2193:
2189:
2185:
2181:
2177:
2173:
2169:
2163:
2159:
2155:
2151:
2147:
2143:
2139:
2134:
2130:
2126:
2122:
2118:
2113:
2108:
2104:
2100:
2096:
2091:
2087:
2083:
2079:
2075:
2071:
2067:
2063:
2059:
2055:
2051:
2046:
2042:
2038:
2034:
2030:
2025:
2020:
2017:(5): 676–82.
2016:
2012:
2008:
2003:
1999:
1995:
1991:
1987:
1983:
1979:
1975:
1971:
1966:
1965:
1960:
1951:
1947:
1942:
1937:
1932:
1927:
1923:
1919:
1918:J. Biol. Chem
1915:
1908:
1905:
1900:
1896:
1891:
1886:
1882:
1878:
1874:
1870:
1866:
1859:
1856:
1851:
1847:
1842:
1837:
1833:
1829:
1825:
1821:
1817:
1810:
1807:
1802:
1796:
1794:
1790:
1785:
1781:
1776:
1771:
1768:(11): 614–9.
1767:
1763:
1762:J. Hum. Genet
1759:
1752:
1749:
1744:
1740:
1735:
1730:
1726:
1722:
1718:
1714:
1710:
1703:
1700:
1695:
1691:
1685:
1682:
1677:
1673:
1667:
1664:
1660:
1656:
1651:
1649:
1647:
1643:
1639:
1635:
1630:
1628:
1626:
1622:
1615:
1613:
1611:
1607:
1599:
1597:
1594:
1590:
1586:
1582:
1578:
1574:
1569:
1561:
1559:
1557:
1554:
1550:
1547:(JNK3) is an
1546:
1542:
1530:
1525:
1521:
1517:
1514:
1510:
1503:
1501:
1498:
1494:
1490:
1486:
1483:
1479:
1475:
1468:
1466:
1462:
1458:
1454:
1450:
1446:
1442:
1438:
1434:
1430:
1426:
1422:
1418:
1414:
1410:
1406:
1402:
1398:
1394:
1390:
1384:
1380:
1376:
1372:
1368:
1364:
1360:
1357:
1351:
1349:
1345:
1341:
1337:
1333:
1327:
1323:
1319:
1315:
1311:
1307:
1303:
1300:
1296:
1289:
1287:
1283:
1277:
1273:
1269:
1265:
1261:
1257:
1253:
1250:
1244:
1242:
1238:
1234:
1230:
1226:
1220:
1216:
1212:
1208:
1204:
1200:
1196:
1193:
1191:RefSeq (mRNA)
1189:
1182:
1181:
1176:
1172:
1169:
1163:
1162:
1158:
1153:
1149:
1146:
1144:
1140:
1133:
1132:
1127:
1123:
1120:
1114:
1113:
1108:
1104:
1101:
1099:
1095:
1088:
1087:
1082:
1078:
1075:
1069:
1068:
1063:
1059:
1056:
1054:
1050:
1047:
1044:
1042:
1039:
1035:
1032:
1028:
1024:
1017:
1013:
1008:
1002:
999:
997:
994:
992:
989:
987:
984:
982:
979:
977:
974:
972:
969:
967:
964:
962:
959:
957:
954:
952:
949:
947:
944:
942:
939:
937:
934:
932:
929:
927:
924:
922:
919:
917:
914:
912:
909:
907:
904:
903:
901:
898:
897:
891:
888:
886:
883:
881:
878:
876:
873:
871:
868:
866:
863:
861:
858:
856:
853:
851:
850:mitochondrion
848:
846:
843:
841:
838:
837:
835:
832:
831:
825:
822:
820:
817:
815:
812:
810:
807:
805:
802:
800:
797:
795:
792:
790:
787:
785:
782:
780:
777:
776:
774:
771:
770:
767:
766:Gene ontology
763:
759:
747:
742:
738:
733:
730:
728:
724:
716:
711:
700:
696:
692:
688:
684:
680:
676:
672:
668:
664:
663:
660:
656:
651:
648:
638:
634:
630:
626:
622:
618:
614:
610:
606:
602:
601:
598:
594:
589:
586:
585:
582:
580:
576:
574:
573:
569:
568:
565:
563:
559:
555:
551:
547:
539:
534:
530:
526:
521:
511:
507:
500:
493:
487:
480:
472:
468:
464:
459:
455:
450:
446:
438:
433:
429:
425:
420:
410:
406:
399:
392:
386:
379:
375:
369:
365:
361:
356:
352:
347:
343:
339:
335:
331:
327:
323:
319:
315:
311:
307:
303:
295:
290:
283:
278:
273:
262:
260:
256:
252:
248:
244:
240:
236:
232:
228:
224:
220:
216:
212:
208:
204:
200:
196:
192:
188:
184:
180:
176:
172:
168:
164:
160:
156:
152:
148:
144:
140:
136:
132:
128:
124:
120:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
5217:expanding it
5209:chromosome 4
5202:
5187:
5149:Translocases
5146:
5133:
5120:
5107:
5094:
5084:Transferases
5081:
5068:
4925:Binding site
4461:
4356:P70S6 kinase
3005:
2990:
2975:
2960:
2945:
2930:
2915:
2900:
2885:
2870:
2855:
2840:
2825:
2810:
2795:
2780:
2720:
2659:
2655:
2621:
2617:
2584:
2580:
2555:
2552:Biochemistry
2551:
2515:
2511:
2472:
2468:
2432:(3): 385–8.
2429:
2425:
2394:
2390:
2359:
2355:
2318:
2314:
2286:
2282:
2253:
2249:
2208:
2204:
2171:
2167:
2141:
2137:
2105:(1): 67–78.
2102:
2098:
2053:
2049:
2014:
2010:
1973:
1970:Immunol. Res
1969:
1921:
1917:
1907:
1872:
1868:
1858:
1823:
1819:
1809:
1765:
1761:
1751:
1716:
1712:
1702:
1693:
1684:
1675:
1666:
1603:
1600:Interactions
1571:Through its
1565:
1552:
1544:
1540:
1539:
1465:NP_001394530
1461:NP_001394529
1457:NP_001394528
1453:NP_001394524
1449:NP_001394521
1445:NP_001394518
1441:NP_001394517
1437:NP_001394515
1433:NP_001394513
1429:NP_001394509
1425:NP_001394508
1421:NP_001394507
1417:NP_001394506
1413:NP_001394505
1409:NP_001394504
1405:NP_001394503
1401:NP_001394502
1397:NP_001394501
1389:NP_001305060
1386:
1379:NP_001305031
1375:NP_001297615
1371:NP_001297614
1367:NP_001297612
1363:NP_001075036
1344:NP_001350586
1340:NP_001338554
1336:NP_001338553
1329:
1314:NP_001304998
1310:NP_001304997
1306:NP_001304996
1286:NM_001318131
1282:NM_001318102
1279:
1272:NM_001310686
1268:NM_001310685
1264:NM_001310683
1256:NM_001081567
1241:NM_001363657
1237:NM_001351625
1233:NM_001351624
1229:NM_001318069
1225:NM_001318068
1222:
1215:NM_001318067
1178:
1155:
1129:
1110:
1084:
1065:
1045:
1040:
1001:MAPK cascade
669:motor neuron
639:frontal pole
577:
570:
536:103,359,200
523:103,055,814
297:External IDs
72:
4920:Active site
4807:(EC 2.7.12)
4194:Polo kinase
4134:Polo kinase
2763:PDB gallery
2315:Ann. Neurol
946:JNK cascade
875:nucleoplasm
814:ATP binding
515:5|5 E5
435:86,594,625
422:85,990,007
275:Identifiers
5256:Categories
5123:Isomerases
5097:Hydrolases
4964:Regulation
3485:IκB kinase
3060:2.7.11-12)
2391:Genome Res
1661:, May 2017
1640:, May 2017
1616:References
1568:MAP kinase
880:perikaryon
581:(ortholog)
318:HomoloGene
5267:EC 2.7.11
5207:on human
5002:EC number
3611:PKC alpha
2426:FEBS Lett
2356:Structure
1941:2297/2692
1581:apoptosis
1393:NP_033184
1332:NP_620448
1322:NP_620446
1318:NP_002744
1260:NM_009158
1211:NM_138982
1207:NM_138981
1203:NM_138980
1199:NM_002753
1031:Orthologs
865:cytoplasm
681:subiculum
326:GeneCards
5026:Kinetics
4950:Cofactor
4913:Activity
3967:KIAA0999
3862:MAPKAPK5
3857:MAPKAPK3
3852:MAPKAPK2
2702:Archived
2684:34298842
2676:11231586
2646:84778351
2638:11185509
2609:11090355
2572:10715136
2542:10629060
2499:10523642
2456:32690852
2448:10471813
2343:36951375
2283:Oncogene
2196:23787450
2129:14107133
2086:29557176
2041:11362623
2033:12960231
1998:32006625
1990:12857973
1950:12189133
1899:10629060
1850:10523642
1784:12436199
1657:–
1636:–
1610:MAPK8IP3
1606:interact
1591:(MKK4).
1562:Function
1513:Wikidata
1010:Sources:
845:membrane
5182:Biology
5136:Ligases
4906:Enzymes
4626:MAP3K14
4604:MAP3K11
4599:MAP3K10
4589:MAP3K13
4584:MAP3K12
4386:RPS6KC1
4381:RPS6KA1
4376:RPS6KA3
4371:RPS6KA2
4366:RPS6KB2
4351:RPS6KA4
4346:RPS6KA5
3997:Kalirin
3962:SNF1LK2
3201:EIF2AK4
3196:EIF2AK3
3050:Kinases
2727:PDBe-KB
2717:UniProt
2618:Science
2589:Bibcode
2581:Science
2413:9847074
2378:9739089
2335:9403476
2305:9393873
2270:9373149
2241:4430535
2233:9349820
2213:Bibcode
2188:9045910
2158:8125298
2121:7826642
2078:1922387
2058:Bibcode
1743:8654373
1659:Ensembl
1638:Ensembl
1143:UniProt
1098:Ensembl
1037:Species
1016:QuickGO
860:nucleus
840:cytosol
556:pattern
314:1346863
282:Aliases
5168:Portal
5110:Lyases
4856:MAP2K7
4851:MAP2K6
4846:MAP2K5
4841:MAP2K4
4836:MAP2K3
4831:MAP2K2
4826:MAP2K1
4777:ACVRL1
4772:ACVR2B
4767:ACVR2A
4762:ACVR1C
4757:ACVR1B
4740:BMPR1B
4735:BMPR1A
4609:MAP3K7
4594:MAP3K9
4545:MAP3K8
4540:MAP3K7
4535:MAP3K6
4530:MAP3K5
4525:MAP3K4
4520:MAP3K3
4515:MAP3K2
4510:MAP3K1
4484:MAPK14
4479:MAPK13
4474:MAPK11
4462:MAPK10
4440:MAPK15
4435:MAPK12
4327:CDC2L1
4302:CDC2L5
3977:SNF1LK
3802:CAMK2G
3797:CAMK2D
3792:CAMK2B
3787:CAMK2A
3777:CAMK1G
3772:CAMK1D
3767:CAMK1B
3762:CAMK1A
3616:PRKCB1
3553:PRKACA
3548:PRKACB
3543:PRKACG
3519:IKBKAP
3345:BCKDHB
3340:BCKDHA
3314:PRKAG3
3309:PRKAG2
3304:PRKAG1
3294:PRKAB2
3289:PRKAB1
3279:PRKAA2
3274:PRKAA1
3119:STK38L
2722:P53779
2682:
2674:
2644:
2636:
2607:
2570:
2540:
2530:
2497:
2487:
2454:
2446:
2411:
2376:
2341:
2333:
2303:
2268:
2239:
2231:
2205:Nature
2194:
2186:
2156:
2127:
2119:
2099:Neuron
2084:
2076:
2050:Nature
2039:
2031:
1996:
1988:
1948:
1897:
1887:
1848:
1838:
1782:
1741:
1734:450211
1731:
1713:EMBO J
1553:MAPK10
1549:enzyme
1499:search
1497:PubMed
1180:Q61831
1161:Q499Y8
1157:P53779
1053:Entrez
727:BioGPS
414:4q21.3
330:MAPK10
306:602897
289:MAPK10
22:MAPK10
5211:is a
5062:Types
4818:MAP2K
4752:ACVR1
4745:BMPR2
4730:BMPR1
4655:GSK-3
4496:MAP3K
4457:MAPK9
4452:MAPK8
4430:MAPK7
4425:MAPK6
4420:MAPK4
4415:MAPK3
4410:MAPK1
4322:PFTK1
4317:PCTK3
4312:PCTK2
4307:PCTK1
4297:CDK12
4292:CDK10
4267:CDKL5
4247:CDKL2
4124:STK19
4119:EEF2K
4100:PHKG2
4095:PHKG1
4085:PHKA2
4080:PHKA1
4061:MYLK4
4056:MYLK3
4051:MYLK2
4027:DCLK1
4022:Titin
4012:TRIB3
4007:TRIB2
4002:TRIB1
3992:TSSK2
3972:STK40
3957:PSKH1
3952:PRKD3
3947:PRKD2
3927:PHKG2
3922:PHKG1
3912:OBSCN
3907:NUAK2
3902:NUAK1
3897:MKNK2
3892:MKNK1
3882:MARK4
3877:MARK3
3872:MARK2
3867:MARK1
3847:STK11
3842:DAPK3
3837:DAPK2
3832:DAPK1
3827:CHEK2
3822:CHEK1
3807:CAMK4
3782:CAMK2
3757:CAMK1
3752:BRSK2
3646:PRKCQ
3641:PRKCI
3636:PRKCG
3631:PRKCH
3626:PRKCE
3621:PRKCD
3582:PRKG1
3514:IKBKG
3509:IKBKE
3458:STK10
3453:FASTK
3379:IDH3G
3374:IDH3B
3369:IDH3A
3335:BCKDK
3129:ROCK1
3114:STK38
3109:MAST2
3104:MAST1
3099:LATS2
3094:LATS1
2680:S2CID
2642:S2CID
2533:85220
2490:84763
2452:S2CID
2339:S2CID
2237:S2CID
2192:S2CID
2125:S2CID
2082:S2CID
2037:S2CID
1994:S2CID
1890:85220
1841:84763
1608:with
1086:26414
1046:Mouse
1041:Human
1012:Amigo
579:Mouse
572:Human
519:Start
454:Mouse
418:Start
351:Human
322:56439
5213:stub
5205:gene
5154:list
5147:EC7
5141:list
5134:EC6
5128:list
5121:EC5
5115:list
5108:EC4
5102:list
5095:EC3
5089:list
5082:EC2
5076:list
5069:EC1
4645:TPK1
4621:CDC7
4579:MLKs
4572:KSR2
4567:KSR1
4562:BRAF
4557:ARAF
4552:RAFs
4287:CDK9
4282:CDK8
4277:CDK7
4272:CDK6
4262:CDK5
4257:CDK4
4252:CDK3
4242:CDK2
4237:CDK1
4218:PLK4
4213:PLK3
4208:PLK2
4203:PLK1
4158:PLK4
4153:PLK3
4148:PLK2
4143:PLK1
4090:PHKB
4046:MYLK
4017:TRIO
3987:SPEG
3982:SNRK
3942:PKD1
3937:PIM2
3932:PIM1
3917:PASK
3887:MELK
3817:CASK
3812:MLCK
3733:GRK6
3728:GRK5
3723:GRK4
3661:PKN3
3656:PKN2
3558:PRKY
3504:TBK1
3499:IKK2
3494:CHUK
3398:STK4
3364:IDH2
3249:PDK4
3244:PDK3
3239:PDK2
3234:PDK1
3213:WEE1
3208:Wee1
3176:mTOR
3164:AKT3
3159:AKT2
3154:AKT1
3144:SGK3
3139:SGK2
3006:2ok1
2991:2o2u
2976:2o0u
2961:2no3
2946:2h96
2931:2gmx
2916:2g01
2901:2exc
2886:2b1p
2871:1uki
2856:1ukh
2841:1pmv
2826:1pmu
2811:1pmq
2796:1pmn
2781:1jnk
2715:for
2672:PMID
2634:PMID
2605:PMID
2568:PMID
2538:PMID
2495:PMID
2444:PMID
2409:PMID
2374:PMID
2331:PMID
2301:PMID
2266:PMID
2250:Gene
2229:PMID
2184:PMID
2154:PMID
2138:Gene
2117:PMID
2074:PMID
2029:PMID
1986:PMID
1946:PMID
1895:PMID
1846:PMID
1780:PMID
1739:PMID
1575:and
1556:gene
1067:5602
562:Bgee
510:Band
471:Chr.
409:Band
368:Chr.
302:OMIM
259:4X21
255:4Z9L
251:4Y5H
247:4Y46
243:4WHZ
239:4W4Y
235:4W4X
231:4W4W
227:4W4V
223:4U79
219:4KKH
215:4KKG
211:4H3B
207:4H39
203:4H36
199:3V6S
195:3V6R
191:3TTJ
187:3TTI
183:3RTP
179:3PTG
175:3OY1
171:3OXI
167:3KVX
163:3G9N
159:3G9L
155:3G90
151:3FV8
147:3FI3
143:3FI2
139:3DA6
135:3CGO
131:3CGF
127:2ZDU
123:2ZDT
119:2WAJ
115:2R9S
111:2P33
107:2OK1
103:2O2U
99:2O0U
95:2EXC
91:2B1P
87:1PMV
83:1PMU
79:1PMN
75:1JNK
56:RCSB
53:PDBe
4650:TTK
4614:ZAK
3191:HRI
3186:PKR
3134:SGK
3124:CIT
2713:PDB
2664:doi
2626:doi
2622:290
2597:doi
2585:290
2560:doi
2528:PMC
2520:doi
2485:PMC
2477:doi
2434:doi
2430:457
2399:doi
2364:doi
2323:doi
2291:doi
2258:doi
2254:200
2221:doi
2209:389
2176:doi
2146:doi
2142:138
2107:doi
2066:doi
2054:353
2019:doi
1978:doi
1936:hdl
1926:doi
1922:277
1885:PMC
1877:doi
1836:PMC
1828:doi
1770:doi
1729:PMC
1721:doi
532:End
431:End
334:OMA
310:MGI
46:PDB
5258::
3300:γ
3285:β
3270:α
3058:EC
3052::
2719::
2678:.
2670:.
2658:.
2640:.
2632:.
2620:.
2603:.
2595:.
2583:.
2566:.
2556:39
2554:.
2536:.
2526:.
2516:20
2514:.
2510:.
2493:.
2483:.
2473:19
2471:.
2467:.
2450:.
2442:.
2428:.
2424:.
2407:.
2393:.
2389:.
2372:.
2358:.
2354:.
2337:.
2329:.
2319:42
2317:.
2299:.
2287:15
2285:.
2281:.
2264:.
2252:.
2235:.
2227:.
2219:.
2207:.
2190:.
2182:.
2172:27
2170:.
2152:.
2140:.
2123:.
2115:.
2103:14
2101:.
2097:.
2080:.
2072:.
2064:.
2052:.
2035:.
2027:.
2015:74
2013:.
2009:.
1992:.
1984:.
1974:27
1972:.
1944:.
1934:.
1920:.
1916:.
1893:.
1883:.
1873:20
1871:.
1867:.
1844:.
1834:.
1824:19
1822:.
1818:.
1792:^
1778:.
1766:47
1764:.
1760:.
1737:.
1727:.
1717:15
1715:.
1711:.
1692:.
1674:.
1645:^
1624:^
1612:.
1583:.
1558:.
1014:/
538:bp
525:bp
437:bp
424:bp
332:;
328::
324:;
320::
316:;
312::
308:;
304::
257:,
253:,
249:,
245:,
241:,
237:,
233:,
229:,
225:,
221:,
217:,
213:,
209:,
205:,
201:,
197:,
193:,
189:,
185:,
181:,
177:,
173:,
169:,
165:,
161:,
157:,
153:,
149:,
145:,
141:,
137:,
133:,
129:,
125:,
121:,
117:,
113:,
109:,
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101:,
97:,
93:,
89:,
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81:,
77:,
5244:e
5237:t
5230:v
5219:.
5170::
5156:)
5152:(
5143:)
5139:(
5130:)
5126:(
5117:)
5113:(
5104:)
5100:(
5091:)
5087:(
5078:)
5074:(
4898:e
4891:t
4884:v
4707:-
4690:-
4673:-
3476:-
3056:(
3042:e
3035:t
3028:v
2756:e
2749:t
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2729:.
2708:.
2686:.
2666::
2660:3
2648:.
2628::
2611:.
2599::
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2574:.
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2544:.
2522::
2501:.
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2458:.
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2415:.
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2395:8
2380:.
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2360:6
2345:.
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2307:.
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2272:.
2260::
2243:.
2223::
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2198:.
2178::
2160:.
2148::
2131:.
2109::
2088:.
2068::
2060::
2043:.
2021::
2000:.
1980::
1952:.
1938::
1928::
1901:.
1879::
1852:.
1830::
1803:.
1786:.
1772::
1745:.
1723::
1696:.
1678:.
456:)
353:)
336::
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