324:
301:
198:
223:
575:
330:
229:
1189:(pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication-related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7.
1773:
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P,
57:
1184:
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the
2463:
Kodani I, Shomori K, Osaki M, Kuratate I, Ryoke K, Ito H (2002). "Expression of minichromosome maintenance 2 (MCM2), Ki-67, and cell-cycle-related molecules, and apoptosis in the normal-dysplasia-carcinoma sequence of the oral mucosa".
1952:"Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)"
2014:
Todorov IT, Pepperkok R, Philipova RN, Kearsey SE, Ansorge W, Werner D (1994). "A human nuclear protein with sequence homology to a family of early S phase proteins is required for entry into S phase and for cell division".
1917:"Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1"
1774:
Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network".
2536:
Osaki M, Osaki M, Yamashita H, Shomori K, Yoshida H, Ito H (2003). "Expression of minichromosome maintenance-2 in human malignant fibrous histiocytomas: Correlations with Ki-67 and P53 expression, and apoptosis".
1419:
Mincheva A, Todorov I, Werner D, Fink TM, Lichter P (Jan 1994). "The human gene for nuclear protein BM28 (CDCL1), a new member of the early S-phase family of proteins, maps to chromosome band 3q21".
1384:
Todorov IT, Lavigne J, Sakr F, Kaneva R, Foisy S, Bibor-Hardy V (Jul 1991). "Nuclear matrix protein mitotin messenger RNA is expressed at constant levels during the cell cycle".
337:
236:
1985:
Nakatsuru S, Sudo K, Nakamura Y (1995). "Isolation and mapping of a human gene (MCM2) encoding a product homologous to yeast proteins involved in DNA replication".
2237:"Human Cdc7-related kinase complex. In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a critical threonine residue of Cdc7 bY Cdks"
2272:"The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase"
1212:
1716:"Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma"
903:
884:
159:
1530:
Kneissl M, Pütter V, Szalay AA, Grummt F (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells".
1366:
1348:
2576:
54:
1103:
323:
1110:
300:
2081:"Cell cycle- and chromatin binding state-dependent phosphorylation of human MCM heterohexameric complexes. A role for cdc2 kinase"
1454:
1335:
1314:
2503:"MCM2-7 complexes bind chromatin in a distributed pattern surrounding the origin recognition complex in Xenopus egg extracts"
1331:
222:
197:
1310:
139:
1286:
1198:
336:
235:
1950:
Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (1995).
1915:
Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (1995).
329:
228:
948:
147:
1186:
929:
1272:
1871:"In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP"
2430:"Xenopus Mcm10 binds to origins of DNA replication after Mcm2-7 and stimulates origin binding of Cdc45"
1783:
1727:
211:
130:, BM28, CCNL1, CDCL1, D3S3194, MITOTIN, cdc19, minichromosome maintenance complex component 2, DFNA70
20:
126:
2270:
Izumi M, Yanagi K, Mizuno T, Yokoi M, Kawasaki Y, Moon KY, Hurwitz J, Yatagai F, Hanaoka F (2001).
2489:
1807:
1601:
171:
1086:
1065:
1039:
1018:
1470:"Protein kinase A-anchoring protein AKAP95 interacts with MCM2, a regulator of DNA replication"
2554:
2524:
2481:
2451:
2416:
2381:
2336:
2301:
2258:
2223:
2188:
2145:
2102:
2067:
2032:
2002:
1973:
1938:
1892:
1851:
1799:
1755:
1696:
1655:
1593:
1570:
Yabuta N, Kajimura N, Mayanagi K, Sato M, Gotow T, Uchiyama Y, Ishimi Y, Nojima H (May 2003).
1547:
1491:
1436:
1401:
119:
47:
2546:
2514:
2473:
2441:
2406:
2371:
2361:
2326:
2291:
2283:
2248:
2213:
2178:
2170:
2135:
2127:
2092:
2057:
2024:
1994:
1963:
1928:
1882:
1841:
1830:"Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex"
1791:
1745:
1735:
1686:
1645:
1637:
1583:
1539:
1481:
1428:
1393:
574:
416:
347:
291:
246:
2348:
Tan DF, Huberman JA, Hyland A, Loewen GM, Brooks JS, Beck AF, Todorov IT, Bepler G (2002).
2116:"Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication"
391:
167:
1787:
1731:
1455:"Entrez Gene: MCM2 MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae)"
2140:
2115:
2446:
2429:
2296:
2271:
1543:
818:
813:
808:
803:
798:
793:
788:
783:
778:
773:
768:
763:
758:
753:
737:
732:
727:
722:
717:
712:
707:
702:
697:
681:
676:
671:
666:
661:
656:
651:
646:
641:
636:
631:
626:
621:
616:
2570:
2376:
2349:
2183:
2158:
1750:
1715:
1650:
1625:
1588:
1571:
1397:
603:
2493:
2315:"Replication factors MCM2 and ORC1 interact with the histone acetyltransferase HBO1"
1605:
1468:
Eide T, Taskén KA, Carlson C, Williams G, Jahnsen T, Taskén K, Collas P (Jul 2003).
1811:
409:
188:
151:
175:
2202:"Inhibition of Mcm4,6,7 helicase activity by phosphorylation with cyclin A/Cdk2"
1371:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1353:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2350:"MCM2--a promising marker for premalignant lesions of the lung: a cohort study"
2131:
814:
pre-replicative complex assembly involved in nuclear cell cycle DNA replication
492:
2501:
Edwards MC, Tutter AV, Cvetic C, Gilbert CH, Prokhorova TA, Walter JC (2002).
308:
205:
155:
2287:
2097:
2080:
2062:
2045:
1887:
1870:
1691:
1674:
2159:"Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity"
1968:
1951:
1933:
1916:
1626:"Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity"
848:
552:
430:
375:
362:
274:
261:
163:
2558:
2528:
2519:
2502:
2485:
2455:
2420:
2411:
2394:
2385:
2340:
2331:
2314:
2305:
2262:
2253:
2236:
2227:
2218:
2201:
2192:
2174:
2149:
1855:
1846:
1829:
1803:
1759:
1740:
1659:
1641:
1597:
1551:
1495:
1486:
1469:
2550:
2366:
2106:
2071:
2036:
2028:
2006:
1977:
1942:
1896:
1700:
1440:
1405:
1150:
1145:
2079:
Fujita M, Yamada C, Tsurumi T, Hanaoka F, Matsuzawa K, Inagaki M (1998).
1134:
993:
974:
1795:
1166:
960:
915:
2477:
2046:"Binding of human minichromosome maintenance proteins with histone H3"
1998:
1675:"Binding of human minichromosome maintenance proteins with histone H3"
1432:
96:
92:
88:
84:
80:
76:
1118:
870:
2428:
Wohlschlegel JA, Dhar SK, Prokhorova TA, Dutta A, Walter JC (2002).
1266:
1260:
1254:
1248:
1206:
833:
829:
1242:
1236:
1230:
1224:
1218:
1173:
143:
2200:
Ishimi Y, Komamura-Kohno Y, You Z, Omori A, Kitagawa M (2000).
583:
2235:
Masai H, Matsui E, You Z, Ishimi Y, Tamai K, Arai K (2000).
1673:
Ishimi Y, Ichinose S, Omori A, Sato K, Kimura H (Sep 1996).
2395:"Biochemical activities associated with mouse Mcm2 protein"
1572:"Mammalian Mcm2/4/6/7 complex forms a toroidal structure"
2044:
Ishimi Y, Ichinose S, Omori A, Sato K, Kimura H (1996).
809:
double-strand break repair via break-induced replication
399:
1869:
Fujita M, Kiyono T, Hayashi Y, Ishibashi M (Apr 1997).
564:
2393:
Ishimi Y, Komamura-Kohno Y, Arai K, Masai H (2001).
1079:
1058:
1032:
1011:
1327:
1325:
1323:
1306:
1304:
1302:
713:nuclear origin of replication recognition complex
346:
245:
1828:You Z, Ishimi Y, Masai H, Hanaoka F (Nov 2002).
2114:Jiang W, McDonald D, Hope TJ, Hunter T (1999).
1823:
1821:
1619:
1617:
1615:
1565:
1563:
1561:
1525:
16:Protein-coding gene in the species Homo sapiens
2313:Burke TW, Cook JG, Asano M, Nevins JR (2001).
1523:
1521:
1519:
1517:
1515:
1513:
1511:
1509:
1507:
1505:
1332:GRCm38: Ensembl release 89: ENSMUSG00000002870
19:"MCM-2" redirects here. For the warship, see
8:
1213:Cell division cycle 7-related protein kinase
804:negative regulation of DNA helicase activity
1311:GRCh38: Ensembl release 89: ENSG00000073111
1714:DaFonseca CJ, Shu F, Zhang JJ (Mar 2001).
844:
599:
387:
286:
183:
65:
2518:
2445:
2410:
2375:
2365:
2330:
2295:
2252:
2217:
2182:
2139:
2096:
2061:
1967:
1932:
1886:
1845:
1749:
1739:
1690:
1649:
1587:
1485:
779:DNA unwinding involved in DNA replication
531:fetal liver hematopoietic progenitor cell
1624:You Z, Komamura Y, Ishimi Y (Dec 1999).
1298:
25:
1163:DNA replication licensing factor MCM2
799:G1/S transition of mitotic cell cycle
677:single-stranded DNA helicase activity
351:
312:
307:
250:
209:
204:
7:
2157:You Z, Komamura Y, Ishimi Y (2000).
1076:
1055:
1029:
1008:
984:
965:
939:
920:
894:
875:
819:mitotic DNA replication initiation
754:cellular response to interleukin-4
569:
487:
425:
404:
14:
1169:that in humans is encoded by the
1589:10.1046/j.1365-2443.2003.00645.x
573:
335:
328:
322:
299:
234:
227:
221:
196:
657:DNA replication origin binding
584:More reference expression data
553:More reference expression data
1:
2447:10.1016/S1097-2765(02)00456-2
1544:10.1016/s0022-2836(03)00079-2
320:
219:
1720:Proc. Natl. Acad. Sci. U.S.A
1398:10.1016/0006-291X(91)91996-P
2577:Genes on human chromosome 3
1287:Mini Chromosome Maintenance
682:3'-5' DNA helicase activity
672:single-stranded DNA binding
2593:
1386:Biochem Biophys Res Commun
774:DNA replication initiation
18:
1367:"Mouse PubMed Reference:"
1349:"Human PubMed Reference:"
1149:
1144:
1140:
1133:
1117:
1098:
1083:
1062:
1051:
1036:
1015:
1004:
991:
987:
972:
968:
959:
946:
942:
927:
923:
914:
901:
897:
882:
878:
869:
854:
847:
843:
827:
602:
598:
581:
572:
563:
550:
499:
490:
437:
428:
398:
390:
386:
369:
356:
319:
298:
289:
285:
268:
255:
218:
195:
186:
182:
137:
134:
124:
117:
112:
73:
68:
51:
46:
41:
37:
33:
28:
2132:10.1093/emboj/18.20.5703
2098:10.1074/jbc.273.27.17095
2063:10.1074/jbc.271.39.24115
1888:10.1074/jbc.272.16.10928
1692:10.1074/jbc.271.39.24115
1104:Chr 3: 127.6 – 127.62 Mb
703:microtubule cytoskeleton
1197:MCM2 has been shown to
1187:pre-replication complex
1111:Chr 6: 88.86 – 88.88 Mb
2520:10.1074/jbc.M204438200
2412:10.1074/jbc.M106861200
2332:10.1074/jbc.M011556200
2288:10.1093/nar/28.23.4769
2254:10.1074/jbc.M002713200
2219:10.1074/jbc.M909040199
2175:10.1128/MCB.19.12.8003
1847:10.1074/jbc.M205769200
1741:10.1073/pnas.061487598
1642:10.1128/MCB.19.12.8003
1487:10.1074/jbc.M300765200
1273:Replication protein A1
2551:10.3892/ijmm.10.2.161
2367:10.1186/1471-2407-1-6
2029:10.1242/jcs.107.1.253
1987:Cytogenet. Cell Genet
1969:10.1093/dnares/1.1.47
1934:10.1093/dnares/1.1.27
642:DNA helicase activity
507:mandibular prominence
1421:Cytogenet Cell Genet
511:maxillary prominence
314:Chromosome 6 (mouse)
212:Chromosome 3 (human)
69:List of PDB id codes
42:Available structures
21:USS Defender (MCM-2)
1796:10.1038/nature04209
1788:2005Natur.437.1173R
1732:2001PNAS...98.3034D
794:cochlea development
759:nucleosome assembly
473:gingival epithelium
457:ganglionic eminence
949:ENSMUSG00000002870
747:Biological process
691:Cellular component
662:hydrolase activity
622:nucleotide binding
610:Molecular function
503:tibiofemoral joint
2478:10.1159/000048770
2325:(18): 15397–408.
2276:Nucleic Acids Res
2091:(27): 17095–101.
1999:10.1159/000133918
1433:10.1159/000133647
1160:
1159:
1156:
1155:
1129:
1128:
1094:
1093:
1073:
1072:
1047:
1046:
1026:
1025:
1000:
999:
981:
980:
955:
954:
936:
935:
910:
909:
891:
890:
839:
838:
784:apoptotic process
637:metal ion binding
627:helicase activity
594:
593:
590:
589:
559:
558:
546:
545:
484:
483:
465:bone marrow cells
382:
381:
281:
280:
108:
107:
104:
103:
52:Ortholog search:
2584:
2562:
2539:Int. J. Mol. Med
2532:
2522:
2513:(36): 33049–57.
2497:
2459:
2449:
2424:
2414:
2405:(46): 42744–52.
2389:
2379:
2369:
2344:
2334:
2309:
2299:
2266:
2256:
2247:(37): 29042–52.
2231:
2221:
2212:(21): 16235–41.
2196:
2186:
2153:
2143:
2110:
2100:
2075:
2065:
2056:(39): 24115–22.
2040:
2010:
1981:
1971:
1946:
1936:
1901:
1900:
1890:
1881:(16): 10928–35.
1866:
1860:
1859:
1849:
1825:
1816:
1815:
1782:(7062): 1173–8.
1770:
1764:
1763:
1753:
1743:
1711:
1705:
1704:
1694:
1685:(39): 24115–22.
1670:
1664:
1663:
1653:
1621:
1610:
1609:
1591:
1567:
1556:
1555:
1527:
1500:
1499:
1489:
1465:
1459:
1458:
1451:
1445:
1444:
1416:
1410:
1409:
1381:
1375:
1374:
1363:
1357:
1356:
1345:
1339:
1329:
1318:
1308:
1142:
1141:
1113:
1106:
1089:
1077:
1068:
1056:
1052:RefSeq (protein)
1042:
1030:
1021:
1009:
985:
966:
940:
921:
895:
876:
845:
600:
586:
577:
570:
555:
539:genital tubercle
535:ventricular zone
527:primitive streak
495:
493:Top expressed in
488:
449:ventricular zone
445:secondary oocyte
433:
431:Top expressed in
426:
405:
388:
378:
365:
354:
339:
332:
326:
315:
303:
287:
277:
264:
253:
238:
231:
225:
214:
200:
184:
178:
176:MCM2 - orthologs
129:
122:
99:
66:
60:
39:
38:
26:
2592:
2591:
2587:
2586:
2585:
2583:
2582:
2581:
2567:
2566:
2565:
2535:
2500:
2462:
2427:
2392:
2347:
2312:
2282:(23): 4769–77.
2269:
2234:
2199:
2169:(12): 8003–15.
2163:Mol. Cell. Biol
2156:
2126:(20): 5703–13.
2113:
2078:
2043:
2013:
1993:(3–4): 226–30.
1984:
1949:
1914:
1910:
1908:Further reading
1905:
1904:
1868:
1867:
1863:
1840:(45): 42471–9.
1827:
1826:
1819:
1772:
1771:
1767:
1713:
1712:
1708:
1672:
1671:
1667:
1636:(12): 8003–15.
1630:Mol. Cell. Biol
1623:
1622:
1613:
1569:
1568:
1559:
1529:
1528:
1503:
1480:(29): 26750–6.
1467:
1466:
1462:
1453:
1452:
1448:
1418:
1417:
1413:
1383:
1382:
1378:
1365:
1364:
1360:
1347:
1346:
1342:
1330:
1321:
1309:
1300:
1295:
1283:
1278:
1195:
1182:
1151:View/Edit Mouse
1146:View/Edit Human
1109:
1102:
1099:Location (UCSC)
1085:
1064:
1038:
1017:
930:ENSG00000073111
823:
769:DNA replication
742:
686:
647:protein binding
632:histone binding
582:
551:
542:
537:
533:
529:
525:
521:
517:
513:
509:
505:
491:
480:
475:
471:
467:
463:
461:trabecular bone
459:
455:
451:
447:
443:
429:
373:
360:
352:
342:
341:
340:
333:
313:
290:Gene location (
272:
259:
251:
241:
240:
239:
232:
210:
187:Gene location (
138:
125:
118:
75:
53:
24:
17:
12:
11:
5:
2590:
2588:
2580:
2579:
2569:
2568:
2564:
2563:
2533:
2498:
2460:
2425:
2390:
2345:
2310:
2267:
2232:
2197:
2154:
2111:
2076:
2041:
2011:
1982:
1947:
1911:
1909:
1906:
1903:
1902:
1861:
1817:
1765:
1706:
1665:
1611:
1557:
1501:
1460:
1446:
1411:
1392:(1): 395–400.
1376:
1358:
1340:
1319:
1297:
1296:
1294:
1291:
1290:
1289:
1282:
1279:
1277:
1276:
1270:
1264:
1258:
1252:
1246:
1240:
1234:
1228:
1222:
1216:
1210:
1203:
1194:
1191:
1181:
1178:
1158:
1157:
1154:
1153:
1148:
1138:
1137:
1131:
1130:
1127:
1126:
1124:
1122:
1115:
1114:
1107:
1100:
1096:
1095:
1092:
1091:
1081:
1080:
1074:
1071:
1070:
1060:
1059:
1053:
1049:
1048:
1045:
1044:
1034:
1033:
1027:
1024:
1023:
1013:
1012:
1006:
1002:
1001:
998:
997:
989:
988:
982:
979:
978:
970:
969:
963:
957:
956:
953:
952:
944:
943:
937:
934:
933:
925:
924:
918:
912:
911:
908:
907:
899:
898:
892:
889:
888:
880:
879:
873:
867:
866:
861:
856:
852:
851:
841:
840:
837:
836:
825:
824:
822:
821:
816:
811:
806:
801:
796:
791:
786:
781:
776:
771:
766:
761:
756:
750:
748:
744:
743:
741:
740:
735:
730:
725:
720:
715:
710:
705:
700:
694:
692:
688:
687:
685:
684:
679:
674:
669:
664:
659:
654:
652:enzyme binding
649:
644:
639:
634:
629:
624:
619:
613:
611:
607:
606:
596:
595:
592:
591:
588:
587:
579:
578:
567:
561:
560:
557:
556:
548:
547:
544:
543:
541:
540:
536:
532:
528:
524:
520:
519:tail of embryo
516:
512:
508:
504:
500:
497:
496:
485:
482:
481:
479:
478:
474:
470:
466:
462:
458:
454:
450:
446:
442:
438:
435:
434:
422:
421:
413:
402:
396:
395:
392:RNA expression
384:
383:
380:
379:
371:
367:
366:
358:
355:
350:
344:
343:
334:
327:
321:
317:
316:
311:
305:
304:
296:
295:
283:
282:
279:
278:
270:
266:
265:
257:
254:
249:
243:
242:
233:
226:
220:
216:
215:
208:
202:
201:
193:
192:
180:
179:
136:
132:
131:
123:
115:
114:
110:
109:
106:
105:
102:
101:
71:
70:
62:
61:
50:
44:
43:
35:
34:
31:
30:
15:
13:
10:
9:
6:
4:
3:
2:
2589:
2578:
2575:
2574:
2572:
2560:
2556:
2552:
2548:
2544:
2540:
2534:
2530:
2526:
2521:
2516:
2512:
2508:
2507:J. Biol. Chem
2504:
2499:
2495:
2491:
2487:
2483:
2479:
2475:
2471:
2467:
2461:
2457:
2453:
2448:
2443:
2440:(2): 233–40.
2439:
2435:
2431:
2426:
2422:
2418:
2413:
2408:
2404:
2400:
2399:J. Biol. Chem
2396:
2391:
2387:
2383:
2378:
2373:
2368:
2363:
2359:
2355:
2351:
2346:
2342:
2338:
2333:
2328:
2324:
2320:
2319:J. Biol. Chem
2316:
2311:
2307:
2303:
2298:
2293:
2289:
2285:
2281:
2277:
2273:
2268:
2264:
2260:
2255:
2250:
2246:
2242:
2241:J. Biol. Chem
2238:
2233:
2229:
2225:
2220:
2215:
2211:
2207:
2206:J. Biol. Chem
2203:
2198:
2194:
2190:
2185:
2180:
2176:
2172:
2168:
2164:
2160:
2155:
2151:
2147:
2142:
2137:
2133:
2129:
2125:
2121:
2117:
2112:
2108:
2104:
2099:
2094:
2090:
2086:
2085:J. Biol. Chem
2082:
2077:
2073:
2069:
2064:
2059:
2055:
2051:
2050:J. Biol. Chem
2047:
2042:
2038:
2034:
2030:
2026:
2023:(1): 253–65.
2022:
2018:
2012:
2008:
2004:
2000:
1996:
1992:
1988:
1983:
1979:
1975:
1970:
1965:
1961:
1957:
1953:
1948:
1944:
1940:
1935:
1930:
1926:
1922:
1918:
1913:
1912:
1907:
1898:
1894:
1889:
1884:
1880:
1876:
1875:J. Biol. Chem
1872:
1865:
1862:
1857:
1853:
1848:
1843:
1839:
1835:
1834:J. Biol. Chem
1831:
1824:
1822:
1818:
1813:
1809:
1805:
1801:
1797:
1793:
1789:
1785:
1781:
1777:
1769:
1766:
1761:
1757:
1752:
1747:
1742:
1737:
1733:
1729:
1726:(6): 3034–9.
1725:
1721:
1717:
1710:
1707:
1702:
1698:
1693:
1688:
1684:
1680:
1679:J. Biol. Chem
1676:
1669:
1666:
1661:
1657:
1652:
1647:
1643:
1639:
1635:
1631:
1627:
1620:
1618:
1616:
1612:
1607:
1603:
1599:
1595:
1590:
1585:
1582:(5): 413–21.
1581:
1577:
1573:
1566:
1564:
1562:
1558:
1553:
1549:
1545:
1541:
1538:(1): 111–28.
1537:
1533:
1526:
1524:
1522:
1520:
1518:
1516:
1514:
1512:
1510:
1508:
1506:
1502:
1497:
1493:
1488:
1483:
1479:
1475:
1474:J. Biol. Chem
1471:
1464:
1461:
1456:
1450:
1447:
1442:
1438:
1434:
1430:
1426:
1422:
1415:
1412:
1407:
1403:
1399:
1395:
1391:
1387:
1380:
1377:
1372:
1368:
1362:
1359:
1354:
1350:
1344:
1341:
1337:
1333:
1328:
1326:
1324:
1320:
1316:
1312:
1307:
1305:
1303:
1299:
1292:
1288:
1285:
1284:
1280:
1274:
1271:
1268:
1265:
1262:
1259:
1256:
1253:
1250:
1247:
1244:
1241:
1238:
1235:
1232:
1229:
1226:
1223:
1220:
1217:
1214:
1211:
1208:
1205:
1204:
1202:
1200:
1192:
1190:
1188:
1179:
1177:
1175:
1172:
1168:
1164:
1152:
1147:
1143:
1139:
1136:
1132:
1125:
1123:
1120:
1116:
1112:
1108:
1105:
1101:
1097:
1090:
1088:
1082:
1078:
1075:
1069:
1067:
1061:
1057:
1054:
1050:
1043:
1041:
1035:
1031:
1028:
1022:
1020:
1014:
1010:
1007:
1005:RefSeq (mRNA)
1003:
996:
995:
990:
986:
983:
977:
976:
971:
967:
964:
962:
958:
951:
950:
945:
941:
938:
932:
931:
926:
922:
919:
917:
913:
906:
905:
900:
896:
893:
887:
886:
881:
877:
874:
872:
868:
865:
862:
860:
857:
853:
850:
846:
842:
835:
831:
826:
820:
817:
815:
812:
810:
807:
805:
802:
800:
797:
795:
792:
790:
787:
785:
782:
780:
777:
775:
772:
770:
767:
765:
762:
760:
757:
755:
752:
751:
749:
746:
745:
739:
736:
734:
731:
729:
726:
724:
721:
719:
716:
714:
711:
709:
706:
704:
701:
699:
696:
695:
693:
690:
689:
683:
680:
678:
675:
673:
670:
668:
665:
663:
660:
658:
655:
653:
650:
648:
645:
643:
640:
638:
635:
633:
630:
628:
625:
623:
620:
618:
615:
614:
612:
609:
608:
605:
604:Gene ontology
601:
597:
585:
580:
576:
571:
568:
566:
562:
554:
549:
538:
534:
530:
526:
522:
518:
514:
510:
506:
502:
501:
498:
494:
489:
486:
476:
472:
468:
464:
460:
456:
452:
448:
444:
440:
439:
436:
432:
427:
424:
423:
420:
418:
414:
412:
411:
407:
406:
403:
401:
397:
393:
389:
385:
377:
372:
368:
364:
359:
349:
345:
338:
331:
325:
318:
310:
306:
302:
297:
293:
288:
284:
276:
271:
267:
263:
258:
248:
244:
237:
230:
224:
217:
213:
207:
203:
199:
194:
190:
185:
181:
177:
173:
169:
165:
161:
157:
153:
149:
145:
141:
133:
128:
121:
116:
111:
100:
98:
94:
90:
86:
82:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
2545:(2): 161–8.
2542:
2538:
2510:
2506:
2472:(3): 150–8.
2469:
2466:Pathobiology
2465:
2437:
2433:
2402:
2398:
2357:
2353:
2322:
2318:
2279:
2275:
2244:
2240:
2209:
2205:
2166:
2162:
2123:
2119:
2088:
2084:
2053:
2049:
2020:
2016:
1990:
1986:
1962:(1): 47–56.
1959:
1955:
1927:(1): 27–35.
1924:
1920:
1878:
1874:
1864:
1837:
1833:
1779:
1775:
1768:
1723:
1719:
1709:
1682:
1678:
1668:
1633:
1629:
1579:
1575:
1535:
1532:J. Mol. Biol
1531:
1477:
1473:
1463:
1449:
1427:(4): 276–7.
1424:
1420:
1414:
1389:
1385:
1379:
1370:
1361:
1352:
1343:
1196:
1193:Interactions
1183:
1170:
1162:
1161:
1084:
1063:
1037:
1016:
992:
973:
947:
928:
902:
883:
863:
858:
415:
408:
273:127,622,436
260:127,598,410
135:External IDs
74:
2017:J. Cell Sci
1576:Genes Cells
723:MCM complex
708:nucleoplasm
667:ATP binding
617:DNA binding
374:88,875,762
361:88,860,456
353:6|6 D1
113:Identifiers
2354:BMC Cancer
1338:, May 2017
1317:, May 2017
1293:References
789:cell cycle
419:(ortholog)
156:HomoloGene
2434:Mol. Cell
1087:NP_032590
1066:NP_004517
1040:NM_008564
1019:NM_004526
849:Orthologs
738:nucleolus
718:chromatin
698:cytoplasm
164:GeneCards
2571:Category
2559:12119552
2529:12087101
2494:11047685
2486:11872961
2456:11864598
2421:11568184
2386:11472637
2341:11278932
2306:11095689
2263:10846177
2228:10748114
2193:10567526
2150:10523313
1856:12207017
1804:16189514
1760:11248027
1660:10567526
1606:27707848
1598:12694531
1552:12614612
1496:12740381
1334:–
1313:–
1281:See also
1199:interact
1180:Function
1135:Wikidata
828:Sources:
764:G1 phase
515:epiblast
477:appendix
2141:1171637
2107:9642275
2072:8798650
2037:8175912
2007:7842741
1978:7584028
1956:DNA Res
1943:7584026
1921:DNA Res
1897:9099751
1812:4427026
1784:Bibcode
1728:Bibcode
1701:8798650
1441:8258304
1406:1710453
1336:Ensembl
1315:Ensembl
1167:protein
961:UniProt
916:Ensembl
855:Species
834:QuickGO
733:cytosol
728:nucleus
394:pattern
120:Aliases
2557:
2527:
2492:
2484:
2454:
2419:
2384:
2374:
2339:
2304:
2297:115166
2294:
2261:
2226:
2191:
2181:
2148:
2138:
2120:EMBO J
2105:
2070:
2035:
2005:
1976:
1941:
1895:
1854:
1810:
1802:
1776:Nature
1758:
1748:
1699:
1658:
1648:
1604:
1596:
1550:
1494:
1439:
1404:
1269:, and
1201:with:
1121:search
1119:PubMed
994:P97310
975:P49736
871:Entrez
565:BioGPS
523:somite
453:embryo
441:oocyte
252:3q21.3
152:105380
144:116945
2490:S2CID
2377:35283
2360:: 6.
2184:84885
1808:S2CID
1751:30602
1651:84885
1602:S2CID
1267:ORC5L
1261:ORC4L
1255:ORC2L
1249:ORC1L
1207:AKAP8
1165:is a
904:17216
864:Mouse
859:Human
830:Amigo
469:gonad
417:Mouse
410:Human
357:Start
292:Mouse
256:Start
189:Human
2555:PMID
2525:PMID
2482:PMID
2452:PMID
2417:PMID
2382:PMID
2337:PMID
2302:PMID
2259:PMID
2224:PMID
2189:PMID
2146:PMID
2103:PMID
2068:PMID
2033:PMID
2003:PMID
1974:PMID
1939:PMID
1893:PMID
1852:PMID
1800:PMID
1756:PMID
1697:PMID
1656:PMID
1594:PMID
1548:PMID
1492:PMID
1437:PMID
1402:PMID
1243:MCM7
1237:MCM6
1231:MCM5
1225:MCM4
1219:MCM3
1174:gene
1171:MCM2
885:4171
400:Bgee
348:Band
309:Chr.
247:Band
206:Chr.
168:MCM2
160:3325
140:OMIM
127:MCM2
97:5JA4
93:5C3I
89:5BO0
85:5BNX
81:5BNV
77:4UUZ
58:RCSB
55:PDBe
29:MCM2
2547:doi
2515:doi
2511:277
2474:doi
2442:doi
2407:doi
2403:276
2372:PMC
2362:doi
2327:doi
2323:276
2292:PMC
2284:doi
2249:doi
2245:275
2214:doi
2210:275
2179:PMC
2171:doi
2136:PMC
2128:doi
2093:doi
2089:273
2058:doi
2054:271
2025:doi
2021:107
1995:doi
1964:doi
1929:doi
1883:doi
1879:272
1842:doi
1838:277
1792:doi
1780:437
1746:PMC
1736:doi
1687:doi
1683:271
1646:PMC
1638:doi
1584:doi
1540:doi
1536:327
1482:doi
1478:278
1429:doi
1394:doi
1390:177
370:End
269:End
172:OMA
148:MGI
48:PDB
2573::
2553:.
2543:10
2541:.
2523:.
2509:.
2505:.
2488:.
2480:.
2470:69
2468:.
2450:.
2436:.
2432:.
2415:.
2401:.
2397:.
2380:.
2370:.
2356:.
2352:.
2335:.
2321:.
2317:.
2300:.
2290:.
2280:28
2278:.
2274:.
2257:.
2243:.
2239:.
2222:.
2208:.
2204:.
2187:.
2177:.
2167:19
2165:.
2161:.
2144:.
2134:.
2124:18
2122:.
2118:.
2101:.
2087:.
2083:.
2066:.
2052:.
2048:.
2031:.
2019:.
2001:.
1991:68
1989:.
1972:.
1958:.
1954:.
1937:.
1923:.
1919:.
1891:.
1877:.
1873:.
1850:.
1836:.
1832:.
1820:^
1806:.
1798:.
1790:.
1778:.
1754:.
1744:.
1734:.
1724:98
1722:.
1718:.
1695:.
1681:.
1677:.
1654:.
1644:.
1634:19
1632:.
1628:.
1614:^
1600:.
1592:.
1578:.
1574:.
1560:^
1546:.
1534:.
1504:^
1490:.
1476:.
1472:.
1435:.
1425:65
1423:.
1400:.
1388:.
1369:.
1351:.
1322:^
1301:^
1176:.
832:/
376:bp
363:bp
275:bp
262:bp
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162:;
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1997::
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1966::
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