298:
275:
172:
197:
549:
304:
203:
1140:(pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Mcm 6 has recently been shown to interact strongly
1814:
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P,
47:
1815:
Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network".
311:
210:
2293:"The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase"
1534:
Enattah NS, Sahi T, Savilahti E, Terwilliger JD, Peltonen L, Järvelä I (February 2002). "Identification of a variant associated with adult-type hypolactasia".
1419:"Characterisation of a human homologue of a yeast cell division cycle gene, MCM6, located adjacent to the 5' end of the lactase gene on chromosome 2q21"
807:
1681:
Kneissl M, Pütter V, Szalay AA, Grummt F (March 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells".
788:
133:
2387:
Enattah NS, Sahi T, Savilahti E, Terwilliger JD, Peltonen L, Järvelä I (2002). "Identification of a variant associated with adult-type hypolactasia".
2036:
Holthoff HP, Hameister H, Knippers R (1997). "A novel human Mcm protein: homology to the yeast replication protein Mis5 and chromosomal location".
2494:
Kneissl M, Pütter V, Szalay AA, Grummt F (2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells".
1399:
1381:
2693:
2609:
Ramachandran N, Hainsworth E, Bhullar B, Eisenstein S, Rosen B, Lau AY, Walter JC, LaBaer J (2004). "Self-assembling protein microarrays".
1015:
297:
1022:
2568:"A new member of the MCM protein family encoded by the human MCM8 gene, located contrapodal to GCD10 at chromosome band 20p12.3-13"
274:
1466:
2336:"Processive DNA helicase activity of the minichromosome maintenance proteins 4, 6, and 7 complex requires forked DNA structures"
1368:
1347:
1176:
appear to differ by truncation of the 3' end, presence or absence of 2 cassette exons, common exons with different boundaries.
1364:
196:
171:
44:
1579:"Lactase persistence DNA variant enhances lactase promoter activity in vitro: functional role as a cis regulatory element"
1343:
113:
1320:
1256:
1089:
1482:"Characterization and structure determination of the Cdt1 binding domain of human minichromosome maintenance (Mcm) 6"
310:
209:
303:
202:
1173:
852:
121:
2426:"Mouse geminin inhibits not only Cdt1-MCM6 interactions but also a novel intrinsic Cdt1 DNA binding activity"
2180:"Cell growth-regulated expression of mammalian MCM5 and MCM6 genes mediated by the transcription factor E2F"
1137:
833:
1306:
1958:"In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP"
1264:
1130:
2618:
2347:
1824:
1183:
185:
2067:"HsMCM6: a new member of the human MCM/P1 family encodes a protein homologous to fission yeast Mis5"
100:
2291:
Izumi M, Yanagi K, Mizuno T, Yokoi M, Kawasaki Y, Moon KY, Hurwitz J, Yatagai F, Hanaoka F (2001).
1227:
994:
947:
2642:
2554:
2412:
2096:
1848:
1750:
1559:
1448:
1234:
145:
998:
973:
943:
922:
2698:
2671:
2634:
2597:
2546:
2511:
2482:
2447:
2404:
2375:
2322:
2279:
2244:
2201:
2166:
2131:
2088:
2053:
2024:
1979:
1938:
1897:
1840:
1796:
1742:
1719:
Yabuta N, Kajimura N, Mayanagi K, Sato M, Gotow T, Uchiyama Y, Ishimi Y, Nojima H (May 2003).
1698:
1651:
1600:
1551:
1513:
1440:
1244:
93:
37:
2654:
Yu Z, Feng D, Liang C (2004). "Pairwise interactions of the six human MCM protein subunits".
2663:
2626:
2587:
2579:
2536:
2503:
2472:
2461:"Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex"
2437:
2396:
2365:
2355:
2312:
2304:
2269:
2234:
2226:
2191:
2156:
2121:
2078:
2045:
2014:
1969:
1928:
1887:
1879:
1832:
1786:
1775:"Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex"
1732:
1690:
1641:
1631:
1590:
1543:
1503:
1493:
1430:
390:
321:
265:
220:
2523:
Yabuta N, Kajimura N, Mayanagi K, Sato M, Gotow T, Uchiyama Y, Ishimi Y, Nojima H (2004).
1099:
548:
365:
141:
2622:
2351:
1828:
2083:
2066:
1646:
1619:
1508:
1481:
2592:
2567:
2507:
2317:
2292:
1694:
1435:
1418:
1136:. The hexameric protein complex formed by the MCM proteins is a key component of the
722:
717:
712:
707:
702:
697:
692:
687:
682:
666:
661:
656:
640:
635:
630:
625:
620:
615:
610:
605:
600:
595:
590:
2687:
2541:
2524:
2370:
2335:
2239:
2214:
1892:
1867:
1737:
1720:
1186:, 3 different transcripts, all with introns, putatively encoding 3 different protein
577:
2646:
2558:
2416:
2100:
1754:
1563:
125:
1852:
1452:
383:
162:
1467:"Entrez Gene: MCM6 minichromosome maintenance deficient 6 homolog (S. cerevisiae)"
149:
2258:"Inhibition of Mcm4,6,7 helicase activity by phosphorylation with cyclin A/Cdk2"
2178:
Ohtani K, Iwanaga R, Nakamura M, Ikeda M, Yabuta N, Tsuruga H, Nojima H (1999).
2110:"A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex"
1417:
Harvey CB, Wang Y, Darmoul D, Phillips A, Mantei N, Swallow DM (December 1996).
1404:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1386:
National Center for
Biotechnology Information, U.S. National Library of Medicine
718:
pre-replicative complex assembly involved in nuclear cell cycle DNA replication
466:
2667:
1093:
282:
179:
129:
2308:
2126:
2109:
2019:
2002:
1974:
1957:
1933:
1916:
2630:
2215:"Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity"
2161:
2144:
1868:"Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity"
1498:
1088:. MCM6 is one of the highly conserved mini-chromosome maintenance proteins (
752:
526:
404:
349:
336:
248:
235:
137:
2675:
2638:
2601:
2550:
2515:
2486:
2477:
2460:
2451:
2442:
2425:
2408:
2379:
2326:
2283:
2274:
2257:
2248:
2230:
2205:
2196:
2179:
2049:
1901:
1883:
1844:
1800:
1791:
1774:
1746:
1702:
1655:
1604:
1555:
1517:
1222:
in the first region (at -13910), in particular, has been shown to function
2170:
2135:
2092:
2057:
2028:
1983:
1942:
1444:
1062:
1057:
2583:
2360:
1595:
1578:
1240:
1219:
1126:
1046:
897:
878:
104:, MCG40308, Mis5, P105MCM, minichromosome maintenance complex component 6
1836:
1636:
1215:
1203:
1197:
1187:
1078:
864:
819:
2003:"Binding of human minichromosome maintenance proteins with histone H3"
1917:"Binding of human minichromosome maintenance proteins with histone H3"
70:
66:
1165:
1133:
1096:
1030:
774:
2400:
2065:
Tsuruga H, Yabuta N, Hosoya S, Tamura K, Endo Y, Nojima H (1997).
1915:
Ishimi Y, Ichinose S, Omori A, Sato K, Kimura H (September 1996).
1547:
1300:
1294:
1288:
737:
733:
1282:
1276:
1270:
1169:
1141:
1119:
1115:
1111:
1085:
117:
2256:
Ishimi Y, Komamura-Kohno Y, You Z, Omori A, Kitagawa M (2000).
1620:"Lactose intolerance: diagnosis, genetic, and clinical factors"
1480:
Wei Z, Liu C, Wu X, Xu N, Zhou B, Liang C, Zhu G (March 2010).
557:
1230:
element capable of differentially activating transcription of
1123:
2143:
Holthoff HP, Baack M, Richter A, Ritzi M, Knippers R (1998).
1148:. observed lack of Cdt1 recruitment of Mcm2-7 to the pre-RC.
1660:" Two variants were associated with lactase persistence..."
1144:
at defined residues, by mutating these target residues Wei
2525:"Mammalian Mcm2/4/6/7 complex forms a toroidal structure"
1956:
Fujita M, Kiyono T, Hayashi Y, Ishibashi M (April 1997).
1721:"Mammalian Mcm2/4/6/7 complex forms a toroidal structure"
2001:
Ishimi Y, Ichinose S, Omori A, Sato K, Kimura H (1996).
713:
double-strand break repair via break-induced replication
373:
1110:
The MCM complex consisting of MCM6 (this protein) and
1773:
You Z, Ishimi Y, Masai H, Hanaoka F (November 2002).
538:
1210:introns, approximately 14 kb and 22 kb upstream of
987:
966:
936:
915:
1360:
1358:
1356:
1339:
1337:
1335:
1618:Mattar R, de Campos Mazo DF, Carrilho FJ (2012).
320:
219:
1768:
1766:
1764:
1714:
1712:
1676:
1674:
1672:
1670:
1668:
1666:
1168:. There are 2 non overlapping alternative last
1529:
1527:
1365:GRCm38: Ensembl release 89: ENSMUSG00000026355
2424:Yanagi K, Mizuno T, You Z, Hanaoka F (2002).
1866:You Z, Komamura Y, Ishimi Y (December 1999).
8:
2459:You Z, Ishimi Y, Masai H, Hanaoka F (2003).
2566:Johnson EM, Kinoshita Y, Daniel DC (2003).
2145:"Human protein MCM6 on HeLa cell chromatin"
1344:GRCh38: Ensembl release 89: ENSG00000076003
1196:contains two of the regulatory regions for
1092:) that are essential for the initiation of
641:single-stranded 3'-5' DNA helicase activity
748:
573:
361:
260:
157:
55:
2591:
2540:
2476:
2441:
2369:
2359:
2316:
2273:
2238:
2195:
2160:
2125:
2082:
2018:
1973:
1932:
1891:
1790:
1736:
1645:
1635:
1594:
1507:
1497:
1434:
703:DNA unwinding involved in DNA replication
501:fetal liver hematopoietic progenitor cell
1331:
15:
1243:in these regions are associated with
1075:DNA replication licensing factor MCM6
708:G1/S transition of mitotic cell cycle
325:
286:
281:
224:
183:
178:
7:
2213:You Z, Komamura Y, Ishimi Y (2000).
1577:Olds LC, Sibley E (September 2003).
1160:, is expressed at very high level.
2084:10.1046/j.1365-2443.1997.1290327.x
984:
963:
933:
912:
888:
869:
843:
824:
798:
779:
543:
461:
399:
378:
14:
1081:that in humans is encoded by the
2542:10.1046/j.1365-2443.2003.00645.x
1738:10.1046/j.1365-2443.2003.00645.x
1202:, the gene encoding the protein
547:
309:
302:
296:
273:
208:
201:
195:
170:
636:DNA replication origin binding
558:More reference expression data
527:More reference expression data
1:
2508:10.1016/S0022-2836(03)00079-2
1695:10.1016/s0022-2836(03)00079-2
1436:10.1016/S0014-5793(96)01189-1
294:
193:
2340:Proc. Natl. Acad. Sci. U.S.A
2694:Genes on human chromosome 2
1321:Mini Chromosome Maintenance
1129:activity, and may act as a
596:single-stranded DNA binding
2715:
2334:Lee JK, Hurwitz J (2001).
698:DNA replication initiation
2668:10.1016/j.jmb.2004.05.024
1400:"Mouse PubMed Reference:"
1382:"Human PubMed Reference:"
1061:
1056:
1052:
1045:
1029:
1023:Chr 1: 128.26 – 128.29 Mb
1016:Chr 2: 135.84 – 135.88 Mb
1010:
991:
970:
959:
940:
919:
908:
895:
891:
876:
872:
863:
850:
846:
831:
827:
818:
805:
801:
786:
782:
773:
758:
751:
747:
731:
591:identical protein binding
576:
572:
555:
546:
537:
524:
473:
464:
411:
402:
372:
364:
360:
343:
330:
293:
272:
263:
259:
242:
229:
192:
169:
160:
156:
111:
108:
98:
91:
86:
63:
58:
41:
36:
31:
27:
23:
18:
2127:10.1074/jbc.272.39.24508
2020:10.1074/jbc.271.39.24115
1975:10.1074/jbc.272.16.10928
1934:10.1074/jbc.271.39.24115
1206:, located in two of the
2631:10.1126/science.1097639
2162:10.1074/jbc.273.13.7320
1499:10.1074/jbc.C109.094599
1255:MCM6 has been shown to
1138:pre-replication complex
723:mitotic DNA replication
2478:10.1074/jbc.M205769200
2443:10.1074/jbc.M206202200
2309:10.1093/nar/28.23.4769
2275:10.1074/jbc.M909040199
2231:10.1128/MCB.19.12.8003
2197:10.1038/sj.onc.1202544
2050:10.1006/geno.1996.0530
1884:10.1128/MCB.19.12.8003
1792:10.1074/jbc.M205769200
1624:Clin Exp Gastroenterol
1307:Replication protein A1
447:metanephric glomerulus
1265:CDC45-related protein
606:DNA helicase activity
485:mandibular prominence
2361:10.1073/pnas.98.1.54
1214:. A substitution of
1184:alternative splicing
497:maxillary prominence
288:Chromosome 1 (mouse)
186:Chromosome 2 (human)
59:List of PDB id codes
32:Available structures
2623:2004Sci...305...86R
2352:2001PNAS...98...54L
1837:10.1038/nature04209
1829:2005Natur.437.1173R
423:ganglionic eminence
327:1 E3|1 55.8 cM
2584:10.1093/nar/gkg395
1637:10.2147/CEG.S32368
1596:10.1093/hmg/ddg244
853:ENSMUSG00000026355
676:Biological process
650:Cellular component
621:hydrolase activity
601:nucleotide binding
584:Molecular function
2572:Nucleic Acids Res
2297:Nucleic Acids Res
2108:Ishimi Y (1997).
1247:into adult life.
1245:lactose tolerance
1072:
1071:
1068:
1067:
1041:
1040:
1006:
1005:
981:
980:
955:
954:
930:
929:
904:
903:
885:
884:
859:
858:
840:
839:
814:
813:
795:
794:
743:
742:
631:helicase activity
568:
567:
564:
563:
533:
532:
520:
519:
458:
457:
356:
355:
255:
254:
82:
81:
78:
77:
42:Ortholog search:
2706:
2679:
2650:
2605:
2595:
2562:
2544:
2519:
2490:
2480:
2455:
2445:
2436:(43): 40871–80.
2420:
2383:
2373:
2363:
2330:
2320:
2287:
2277:
2268:(21): 16235–41.
2252:
2242:
2209:
2199:
2190:(14): 2299–309.
2174:
2164:
2139:
2129:
2120:(39): 24508–13.
2104:
2086:
2061:
2032:
2022:
2013:(39): 24115–22.
1988:
1987:
1977:
1968:(16): 10928–35.
1953:
1947:
1946:
1936:
1927:(39): 24115–22.
1912:
1906:
1905:
1895:
1863:
1857:
1856:
1823:(7062): 1173–8.
1811:
1805:
1804:
1794:
1770:
1759:
1758:
1740:
1716:
1707:
1706:
1678:
1661:
1659:
1649:
1639:
1615:
1609:
1608:
1598:
1574:
1568:
1567:
1531:
1522:
1521:
1511:
1501:
1492:(17): 12469–73.
1477:
1471:
1470:
1463:
1457:
1456:
1438:
1414:
1408:
1407:
1396:
1390:
1389:
1378:
1372:
1362:
1351:
1341:
1054:
1053:
1025:
1018:
1001:
985:
976:
964:
960:RefSeq (protein)
950:
934:
925:
913:
889:
870:
844:
825:
799:
780:
749:
574:
560:
551:
544:
529:
513:efferent ductule
505:primitive streak
469:
467:Top expressed in
462:
443:secondary oocyte
431:endothelial cell
415:ventricular zone
407:
405:Top expressed in
400:
379:
362:
352:
339:
328:
313:
306:
300:
289:
277:
261:
251:
238:
227:
212:
205:
199:
188:
174:
158:
152:
150:MCM6 - orthologs
103:
96:
73:
56:
50:
29:
28:
16:
2714:
2713:
2709:
2708:
2707:
2705:
2704:
2703:
2684:
2683:
2682:
2662:(5): 1197–206.
2653:
2617:(5680): 86–90.
2608:
2578:(11): 2915–25.
2565:
2522:
2493:
2471:(45): 42471–9.
2458:
2423:
2386:
2333:
2303:(23): 4769–77.
2290:
2255:
2225:(12): 8003–15.
2219:Mol. Cell. Biol
2212:
2177:
2142:
2107:
2064:
2035:
2000:
1996:
1994:Further reading
1991:
1955:
1954:
1950:
1914:
1913:
1909:
1878:(12): 8003–15.
1872:Mol. Cell. Biol
1865:
1864:
1860:
1813:
1812:
1808:
1785:(45): 42471–9.
1772:
1771:
1762:
1718:
1717:
1710:
1680:
1679:
1664:
1617:
1616:
1612:
1589:(18): 2333–40.
1583:Hum. Mol. Genet
1576:
1575:
1571:
1533:
1532:
1525:
1479:
1478:
1474:
1465:
1464:
1460:
1429:(2–3): 135–40.
1416:
1415:
1411:
1398:
1397:
1393:
1380:
1379:
1375:
1363:
1354:
1342:
1333:
1329:
1317:
1312:
1253:
1156:The MCM6 gene,
1154:
1108:
1063:View/Edit Mouse
1058:View/Edit Human
1021:
1014:
1011:Location (UCSC)
997:
993:
972:
946:
942:
921:
834:ENSG00000076003
727:
688:DNA replication
671:
645:
616:protein binding
556:
525:
516:
511:
507:
503:
499:
495:
491:
487:
483:
479:
465:
454:
449:
445:
441:
437:
433:
429:
427:trabecular bone
425:
421:
417:
403:
347:
334:
326:
316:
315:
314:
307:
287:
264:Gene location (
246:
233:
225:
215:
214:
213:
206:
184:
161:Gene location (
112:
99:
92:
65:
43:
12:
11:
5:
2712:
2710:
2702:
2701:
2696:
2686:
2685:
2681:
2680:
2651:
2606:
2563:
2520:
2491:
2456:
2421:
2384:
2331:
2288:
2253:
2210:
2175:
2155:(13): 7320–5.
2140:
2105:
2062:
2033:
1997:
1995:
1992:
1990:
1989:
1948:
1907:
1858:
1806:
1760:
1708:
1662:
1610:
1569:
1523:
1472:
1458:
1409:
1391:
1373:
1352:
1330:
1328:
1325:
1324:
1323:
1316:
1313:
1311:
1310:
1304:
1298:
1292:
1286:
1280:
1274:
1268:
1261:
1252:
1249:
1153:
1150:
1107:
1104:
1070:
1069:
1066:
1065:
1060:
1050:
1049:
1043:
1042:
1039:
1038:
1036:
1034:
1027:
1026:
1019:
1012:
1008:
1007:
1004:
1003:
989:
988:
982:
979:
978:
968:
967:
961:
957:
956:
953:
952:
938:
937:
931:
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927:
917:
916:
910:
906:
905:
902:
901:
893:
892:
886:
883:
882:
874:
873:
867:
861:
860:
857:
856:
848:
847:
841:
838:
837:
829:
828:
822:
816:
815:
812:
811:
803:
802:
796:
793:
792:
784:
783:
777:
771:
770:
765:
760:
756:
755:
745:
744:
741:
740:
729:
728:
726:
725:
720:
715:
710:
705:
700:
695:
690:
685:
679:
677:
673:
672:
670:
669:
664:
659:
653:
651:
647:
646:
644:
643:
638:
633:
628:
623:
618:
613:
608:
603:
598:
593:
587:
585:
581:
580:
570:
569:
566:
565:
562:
561:
553:
552:
541:
535:
534:
531:
530:
522:
521:
518:
517:
515:
514:
510:
506:
502:
498:
494:
490:
489:abdominal wall
486:
482:
478:
474:
471:
470:
459:
456:
455:
453:
452:
448:
444:
440:
436:
432:
428:
424:
420:
416:
412:
409:
408:
396:
395:
387:
376:
370:
369:
366:RNA expression
358:
357:
354:
353:
345:
341:
340:
332:
329:
324:
318:
317:
308:
301:
295:
291:
290:
285:
279:
278:
270:
269:
257:
256:
253:
252:
244:
240:
239:
231:
228:
223:
217:
216:
207:
200:
194:
190:
189:
182:
176:
175:
167:
166:
154:
153:
110:
106:
105:
97:
89:
88:
84:
83:
80:
79:
76:
75:
61:
60:
52:
51:
40:
34:
33:
25:
24:
21:
20:
13:
10:
9:
6:
4:
3:
2:
2711:
2700:
2697:
2695:
2692:
2691:
2689:
2677:
2673:
2669:
2665:
2661:
2657:
2652:
2648:
2644:
2640:
2636:
2632:
2628:
2624:
2620:
2616:
2612:
2607:
2603:
2599:
2594:
2589:
2585:
2581:
2577:
2573:
2569:
2564:
2560:
2556:
2552:
2548:
2543:
2538:
2535:(5): 413–21.
2534:
2530:
2526:
2521:
2517:
2513:
2509:
2505:
2502:(1): 111–28.
2501:
2497:
2492:
2488:
2484:
2479:
2474:
2470:
2466:
2465:J. Biol. Chem
2462:
2457:
2453:
2449:
2444:
2439:
2435:
2431:
2430:J. Biol. Chem
2427:
2422:
2418:
2414:
2410:
2406:
2402:
2401:10.1038/ng826
2398:
2394:
2390:
2385:
2381:
2377:
2372:
2367:
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2353:
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2332:
2328:
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2306:
2302:
2298:
2294:
2289:
2285:
2281:
2276:
2271:
2267:
2263:
2262:J. Biol. Chem
2259:
2254:
2250:
2246:
2241:
2236:
2232:
2228:
2224:
2220:
2216:
2211:
2207:
2203:
2198:
2193:
2189:
2185:
2181:
2176:
2172:
2168:
2163:
2158:
2154:
2150:
2149:J. Biol. Chem
2146:
2141:
2137:
2133:
2128:
2123:
2119:
2115:
2114:J. Biol. Chem
2111:
2106:
2102:
2098:
2094:
2090:
2085:
2080:
2077:(6): 381–99.
2076:
2072:
2068:
2063:
2059:
2055:
2051:
2047:
2043:
2039:
2034:
2030:
2026:
2021:
2016:
2012:
2008:
2007:J. Biol. Chem
2004:
1999:
1998:
1993:
1985:
1981:
1976:
1971:
1967:
1963:
1962:J. Biol. Chem
1959:
1952:
1949:
1944:
1940:
1935:
1930:
1926:
1922:
1921:J. Biol. Chem
1918:
1911:
1908:
1903:
1899:
1894:
1889:
1885:
1881:
1877:
1873:
1869:
1862:
1859:
1854:
1850:
1846:
1842:
1838:
1834:
1830:
1826:
1822:
1818:
1810:
1807:
1802:
1798:
1793:
1788:
1784:
1780:
1779:J. Biol. Chem
1776:
1769:
1767:
1765:
1761:
1756:
1752:
1748:
1744:
1739:
1734:
1731:(5): 413–21.
1730:
1726:
1722:
1715:
1713:
1709:
1704:
1700:
1696:
1692:
1689:(1): 111–28.
1688:
1684:
1677:
1675:
1673:
1671:
1669:
1667:
1663:
1657:
1653:
1648:
1643:
1638:
1633:
1629:
1625:
1621:
1614:
1611:
1606:
1602:
1597:
1592:
1588:
1584:
1580:
1573:
1570:
1565:
1561:
1557:
1553:
1549:
1548:10.1038/ng826
1545:
1541:
1537:
1530:
1528:
1524:
1519:
1515:
1510:
1505:
1500:
1495:
1491:
1487:
1483:
1476:
1473:
1468:
1462:
1459:
1454:
1450:
1446:
1442:
1437:
1432:
1428:
1424:
1420:
1413:
1410:
1405:
1401:
1395:
1392:
1387:
1383:
1377:
1374:
1370:
1366:
1361:
1359:
1357:
1353:
1349:
1345:
1340:
1338:
1336:
1332:
1326:
1322:
1319:
1318:
1314:
1308:
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1302:
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1296:
1293:
1290:
1287:
1284:
1281:
1278:
1275:
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1266:
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1258:
1250:
1248:
1246:
1242:
1238:
1236:
1233:
1229:
1225:
1221:
1217:
1213:
1209:
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1201:
1200:
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1189:
1185:
1182:produces, by
1181:
1177:
1175:
1171:
1167:
1163:
1159:
1151:
1149:
1147:
1143:
1139:
1135:
1132:
1131:DNA unwinding
1128:
1125:
1121:
1117:
1113:
1105:
1103:
1101:
1098:
1095:
1091:
1087:
1084:
1080:
1076:
1064:
1059:
1055:
1051:
1048:
1044:
1037:
1035:
1032:
1028:
1024:
1020:
1017:
1013:
1009:
1002:
1000:
996:
990:
986:
983:
977:
975:
969:
965:
962:
958:
951:
949:
945:
939:
935:
932:
926:
924:
918:
914:
911:
909:RefSeq (mRNA)
907:
900:
899:
894:
890:
887:
881:
880:
875:
871:
868:
866:
862:
855:
854:
849:
845:
842:
836:
835:
830:
826:
823:
821:
817:
810:
809:
804:
800:
797:
791:
790:
785:
781:
778:
776:
772:
769:
766:
764:
761:
757:
754:
750:
746:
739:
735:
730:
724:
721:
719:
716:
714:
711:
709:
706:
704:
701:
699:
696:
694:
691:
689:
686:
684:
681:
680:
678:
675:
674:
668:
665:
663:
660:
658:
655:
654:
652:
649:
648:
642:
639:
637:
634:
632:
629:
627:
624:
622:
619:
617:
614:
612:
609:
607:
604:
602:
599:
597:
594:
592:
589:
588:
586:
583:
582:
579:
578:Gene ontology
575:
571:
559:
554:
550:
545:
542:
540:
536:
528:
523:
512:
509:Gonadal ridge
508:
504:
500:
496:
492:
488:
484:
480:
476:
475:
472:
468:
463:
460:
450:
446:
442:
438:
434:
430:
426:
422:
418:
414:
413:
410:
406:
401:
398:
397:
394:
392:
388:
386:
385:
381:
380:
377:
375:
371:
367:
363:
359:
351:
346:
342:
338:
333:
323:
319:
312:
305:
299:
292:
284:
280:
276:
271:
267:
262:
258:
250:
245:
241:
237:
232:
222:
218:
211:
204:
198:
191:
187:
181:
177:
173:
168:
164:
159:
155:
151:
147:
143:
139:
135:
131:
127:
123:
119:
115:
107:
102:
95:
90:
85:
74:
72:
68:
62:
57:
54:
53:
49:
46:
39:
35:
30:
26:
22:
17:
2659:
2656:J. Mol. Biol
2655:
2614:
2610:
2575:
2571:
2532:
2528:
2499:
2496:J. Mol. Biol
2495:
2468:
2464:
2433:
2429:
2395:(2): 233–7.
2392:
2388:
2343:
2339:
2300:
2296:
2265:
2261:
2222:
2218:
2187:
2183:
2152:
2148:
2117:
2113:
2074:
2070:
2044:(1): 131–4.
2041:
2037:
2010:
2006:
1965:
1961:
1951:
1924:
1920:
1910:
1875:
1871:
1861:
1820:
1816:
1809:
1782:
1778:
1728:
1724:
1686:
1683:J. Mol. Biol
1682:
1627:
1623:
1613:
1586:
1582:
1572:
1542:(2): 233–7.
1539:
1535:
1489:
1485:
1475:
1461:
1426:
1422:
1412:
1403:
1394:
1385:
1376:
1254:
1251:Interactions
1239:
1231:
1223:
1211:
1207:
1198:
1193:
1192:
1179:
1178:
1164:contains 18
1161:
1157:
1155:
1145:
1109:
1082:
1074:
1073:
995:NP_001300624
992:
971:
948:NM_001313695
941:
920:
896:
877:
851:
832:
806:
787:
767:
762:
389:
382:
348:128,287,401
335:128,259,327
247:135,876,443
234:135,839,626
109:External IDs
64:
2529:Genes Cells
2346:(1): 54–9.
2071:Genes Cells
1725:Genes Cells
1486:J Biol Chem
1174:transcripts
1100:replication
667:nucleoplasm
657:MCM complex
626:ATP binding
611:DNA binding
481:Paneth cell
451:bone marrow
87:Identifiers
2688:Categories
2389:Nat. Genet
1630:: 113–21.
1536:Nat. Genet
1371:, May 2017
1350:, May 2017
1327:References
1122:possesses
1094:eukaryotic
693:cell cycle
439:glomerulus
393:(ortholog)
130:HomoloGene
1423:FEBS Lett
1241:Mutations
999:NP_032593
974:NP_005906
944:NM_008567
923:NM_005915
753:Orthologs
138:GeneCards
2699:Proteins
2676:15236977
2647:20936301
2639:15232106
2602:12771218
2559:27707848
2551:12694531
2516:12614612
2487:12207017
2452:12192004
2417:21430931
2409:11788828
2380:11136247
2327:11095689
2284:10748114
2249:10567526
2206:10327050
2184:Oncogene
2101:12997515
2038:Genomics
1902:10567526
1845:16189514
1801:12207017
1755:27707848
1747:12694531
1703:12614612
1656:22826639
1605:12915462
1564:21430931
1556:11788828
1518:20202939
1367:–
1346:–
1315:See also
1257:interact
1235:promoter
1228:enhancer
1224:in vitro
1220:cytosine
1188:isoforms
1127:helicase
1106:Function
1047:Wikidata
732:Sources:
683:G1 phase
2619:Bibcode
2611:Science
2348:Bibcode
2171:9516426
2136:9305914
2093:9286856
2058:8921380
2029:8798650
1984:9099751
1943:8798650
1853:4427026
1825:Bibcode
1647:3401057
1509:2857124
1453:1323113
1445:8977093
1369:Ensembl
1348:Ensembl
1216:thymine
1204:lactase
1166:introns
1079:protein
865:UniProt
820:Ensembl
759:Species
738:QuickGO
662:nucleus
368:pattern
126:1298227
94:Aliases
2674:
2645:
2637:
2600:
2593:156728
2590:
2557:
2549:
2514:
2485:
2450:
2415:
2407:
2378:
2368:
2325:
2318:115166
2315:
2282:
2247:
2237:
2204:
2169:
2134:
2099:
2091:
2056:
2027:
1982:
1941:
1900:
1890:
1851:
1843:
1817:Nature
1799:
1753:
1745:
1701:
1654:
1644:
1603:
1562:
1554:
1516:
1506:
1451:
1443:
1303:, and
1259:with:
1226:as an
1172:. The
1134:enzyme
1097:genome
1033:search
1031:PubMed
898:P97311
879:Q14566
775:Entrez
539:BioGPS
477:somite
419:embryo
226:2q21.3
118:601806
2643:S2CID
2555:S2CID
2413:S2CID
2371:14543
2240:84885
2097:S2CID
1893:84885
1849:S2CID
1751:S2CID
1560:S2CID
1449:S2CID
1301:ORC4L
1295:ORC2L
1289:ORC1L
1170:exons
1146:et al
1077:is a
808:17219
768:Mouse
763:Human
734:Amigo
435:gonad
391:Mouse
384:Human
331:Start
266:Mouse
230:Start
163:Human
2672:PMID
2635:PMID
2598:PMID
2547:PMID
2512:PMID
2483:PMID
2448:PMID
2405:PMID
2376:PMID
2323:PMID
2280:PMID
2245:PMID
2202:PMID
2167:PMID
2132:PMID
2089:PMID
2054:PMID
2025:PMID
1980:PMID
1939:PMID
1898:PMID
1841:PMID
1797:PMID
1743:PMID
1699:PMID
1652:PMID
1601:PMID
1552:PMID
1514:PMID
1441:PMID
1283:MCM7
1277:MCM4
1271:MCM2
1218:for
1208:MCM6
1194:MCM6
1180:MCM6
1162:MCM6
1158:MCM6
1152:Gene
1142:Cdt1
1118:and
1112:MCM2
1086:gene
1083:MCM6
789:4175
493:hand
374:Bgee
322:Band
283:Chr.
221:Band
180:Chr.
142:MCM6
134:4322
114:OMIM
101:MCM6
71:2LE8
67:2KLQ
48:RCSB
45:PDBe
19:MCM6
2664:doi
2660:340
2627:doi
2615:305
2588:PMC
2580:doi
2537:doi
2504:doi
2500:327
2473:doi
2469:277
2438:doi
2434:277
2397:doi
2366:PMC
2356:doi
2313:PMC
2305:doi
2270:doi
2266:275
2235:PMC
2227:doi
2192:doi
2157:doi
2153:273
2122:doi
2118:272
2079:doi
2046:doi
2015:doi
2011:271
1970:doi
1966:272
1929:doi
1925:271
1888:PMC
1880:doi
1833:doi
1821:437
1787:doi
1783:277
1733:doi
1691:doi
1687:327
1642:PMC
1632:doi
1591:doi
1544:doi
1504:PMC
1494:doi
1490:285
1431:doi
1427:398
1232:LCT
1212:LCT
1199:LCT
1124:DNA
1090:MCM
344:End
243:End
146:OMA
122:MGI
38:PDB
2690::
2670:.
2658:.
2641:.
2633:.
2625:.
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2009:.
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1978:.
1964:.
1960:.
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