260:
237:
2197:
511:
134:
159:
1960:
2624:
includes a supplementary data set that shows a multiple sequence alignment of the regions surrounding the SNPs and the domain in which the SNP lies. The Gly199 to Arg mutation is located inside an EGF-domain; the Arg1499 to His mutation is located within a kelch domain in the 7-bladed beta-sheet propeller; the Ser2367 to Gly is located within an EGF-Laminin domain. These domain are important to maintaining a properly folded protein and its function.
266:
165:
1968:
2280:
text-mining in STRING. Together, it is with reasonably high confidence that the proteins in red are interacting with MEGF8, and with moderate confidence that the proteins in green interact with MEGF8. The confidence level for the proteins in blue is much lower, which may mean that the two-hybrid assay provided a false positive, or that they actually are interacting.
1697:
amino acid bias was able to be determined. Isoform one is rich in cysteine and glycine, and deficient in isoleucine and lysine. Isoform 2 of MEGF8 was found to have very high levels of cysteine, moderately high levels of glycine, and low levels of isoleucine and lysine. The high levels of cysteine residues contributes to the numerous
1769:: laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF).
2193:. This GeoProfile also indicated that MEGF8 was found to be at moderate to moderately low expression levels in all other tissues examined. NCBI GeoProfile data also provided the tissue expression graph for MEGF8 in humans, which is displayed to the right, further illustrating specific sites and levels of expression
2594:
part of the D1k3ia3 structural domain remains in exon 29, but the kelch repeat has been excised, which could lead to structural issues. Also this variant contains almost 3 PSI domains, and an area of low complexity in exons 32-35, which may allow this variant to function in the cell, but no signal or
1066:
in humans (19q13.2). There are two isoform constructs known for MEGF8, which differ by a 67 amino acid indel. The isoform 2 splice version (analyzed throughout this page) is 2785 amino acids long, and predicted to be 296.6 kdal in mass. Isoform 1 is composed of 2845 amino acids and predicted to weigh
1996:
super family. Each of the seven blades are made up of a four stranded beta-folded motifs. It is also important to note that although many phosphorylation sites are predicted at high confidence, several other topographic predictions (i.e. disulfide bonds, glycosylation, other extracellular features),
1588:
MEGF8 has one known paralog: ATRNL1. The ATRNL1 protein is approximately half the length of MEGF8, and contains several of the same conserved domains, including the CUB domain and transmembrane sequence. It is key to note that ATRNL1 is found in many birds and amphibians, where MEGF8 is not found in
2587:
Spliced out exons 1-6; these exons hold several key domains and motifs including the CUB domain, two PSI domains, a D1k3ia3 structural domain, and a kelch repeat. This may result in a misfolded protein without the structural segments, and inhibit participation in development events (loss of PSI and
1714:
Prediction software PELE from UCSC Biology
Workbench indicated that MEGF8 is primarily composed of beta-folded sheets, with occasional short alpha helix segments. PELE uses eight different prediction programs to compare and confirm predictions, enhancing the confidence level. The beta-folded sheets
2606:
1612:
The promoter having promoter ID number GXP_1262882 and transcript ID GXT_22531930, was predicted with the highest confidence. This promoter is located on the plus strand of chromosome 19, ranging from nucleotide 42829077 to 42830497, making it a 1421 nucleotide long sequence. The promoter sequence
2580:
has spliced out Exon 13. Looking at the attached working conceptual translation, it can be seen that exon 3 does not code for any feature, domain, motif or other functional section of aa, and is likely therefore not key to the function of MEGF8 protein. This is the variant that corresponds to the
1701:
found in the mature protein's folded structure. Overall, MEGF8 has a pH between 6.4 and 7.0, depending on the organism's sequence. Human MEGF8's pH is 6.4. This nearly neutral pH enables the protein to fold properly and inhibits denaturation. The twenty most conserved amino acids, found through a
1696:
MEGF8 is composed of either 2845 amino acids (Isoform 1) or 2778 amino acids (Isoform 2). Isoform 2 undergoes a 67 amino acid removal from 700-766, which accounts for its shortened length; otherwise, the two isoforms are identical. Using SAPS, a
Statistical Analysis of Protein Sequence software,
1750:: Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains.
3064:
Marchler-Bauer A, Lu S, Anderson JB, Chitsaz F, Derbyshire MK, DeWeese-Scott C, Fong JH, Geer LY, Geer RC, Gonzales NR, Gwadz M, Hurwitz DI, Jackson JD, Ke Z, Lanczycki CJ, Lu F, Marchler GH, Mullokandov M, Omelchenko MV, Robertson CL, Song JS, Thanki N, Yamashita RA, Zhang D, Zhang N, Zheng C,
1098:
A fairly highly conserved protein, MEGF8 has conserved orthologs from P. paniscus to N. vectensis. Orthologs are found in mammals, amphibians, fish, insects, crustaceans, and invertebrates. Organization of the data showed that as time since divergence between humans and orthologs increased, the
2623:
There are several SNPs, found through NCBI GeneView, that cause missense or silent mutations in MEGF8. However, three SNP mutations were identified as causes of
Carpenter Syndrome 2 by Twigg et al. The three SNP mutations are: Gly199 to Arg; Arg1499 to His; Ser2367 to Gly. The article by Twigg
1071:
searches, orthologs were found primarily in mammals, but MEGF8 is also conserved in invertebrates and fishes, and rarely in birds, reptiles, and amphibians. A notably important paralog to multiple epidermal growth factor-like domains 8 is ATRNL1 (Attractin-like 1), which is also a single pass
2279:
In the table below, all predicted interactions, except SMARCD3, are supported by two-hybrid screen experimental data. This information is supported by both NextProt database and IntAct database. The two interactions with the highest confidence value are also supported by materials found by
1726:
MEGF8 is predicted to contain several different types of features, domains, and motifs that play a key role in the protein's function, structure, and location. These are listed in Table 1. Functions, found through SMART analysis, as well as NCBI Conserved
Domains Search include:
3678:
Kerrien S, Aranda B, Breuza L, Bridge A, Broackes-Carter F, Chen C, Duesbury M, Dumousseau M, Feuermann M, Hinz U, Jandrasits C, Jimenez RC, Khadake J, Mahadevan U, Masson P, Pedruzzi I, Pfeiffenberger E, Porras P, Raghunath A, Roechert B, Orchard S, Hermjakob H (January 2012).
2601:
This variant is exons 36-40, excised 41, and a shortened 42 exon. It possesses EGF calcium domains and EGF/EGF-like domains. Loss of 41 will drastically alter the function as it possesses the TMEM segment. It depends on where 41 is lost and 42 is cleaved.
2453:
Mediates the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell
2691:
There is no research being done currently to develop treatment or cures for
Carpenter Syndrome 2. Researchers are still striving to understand the cause of the point mutations in MEGF8 that result in this extremely rare genetic disease.
1080:
located in
Heidelberg, Germany. MEGF8 has been predicted to be a key player in several developmental processes, such as left-right patterning and limb formation. Currently, researchers have found MEGF8 SNP mutations to be the cause of
2364:
Essential proto-oncogenic transcriptional regulator; Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling
3360:
4169:
Zhang Z, Alpert D, Francis R, Chatterjee B, Yu Q, Tansey T, Sabol SL, Cui C, Bai Y, Koriabine M, Yoshinaga Y, Cheng JF, Chen F, Martin J, Schackwitz W, Gunn TM, Kramer KL, De Jong PJ, Pennacchio LA, Lo CW (March 2009).
2786:
Zhang Z, Alpert D, Francis R, Chatterjee B, Yu Q, Tansey T, Sabol SL, Cui C, Bai Y, Koriabine M, Yoshinaga Y, Cheng JF, Chen F, Martin J, Schackwitz W, Gunn TM, Kramer KL, De Jong PJ, Pennacchio LA, Lo CW (March 2009).
2644:
Mutations in MEGF8 have been found to be linked to defective lateralization during development, as reported by Twigg et al. Common features of individuals with
Carpenter Syndrome Subtype II include the following:
2423:
Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation. Necessary for microtubule cytoskeleton
1715:
occur at many of the key domains, including the EGF-domains, kelch domains, and EGF-laminin domains. This information from PELE also corresponded with the secondary structure and 3D structure predictions made by
1788:
are involved in the development of neural and epithelial tissues; semaphorins induce the collapse and paralysis of neuronal growth cones; and integrins may mediate adhesive or migratory functions of epithelial
4125:
Twigg SR, Lloyd D, Jenkins D, Elçioglu NE, Cooper CD, Al-Sannaa N, Annagür A, Gillessen-Kaesbach G, Hüning I, Knight SJ, Goodship JA, Keavney BD, Beales PL, Gileadi O, McGowan SJ, Wilkie AO (November 2012).
3834:
Twigg SR, Lloyd D, Jenkins D, Elçioglu NE, Cooper CD, Al-Sannaa N, Annagür A, Gillessen-Kaesbach G, Hüning I, Knight SJ, Goodship JA, Keavney BD, Beales PL, Gileadi O, McGowan SJ, Wilkie AO (November 2012).
3931:
Cohen DM, Green JG, Miller J, Gorlin RJ, Reed JA (October 1987). "Acrocephalopolysyndactyly type II--Carpenter syndrome: clinical spectrum and an attempt at unification with
Goodman and Summit syndromes".
3526:
Barrett T, Troup DB, Wilhite SE, Ledoux P, Evangelista C, Kim IF, Tomashevsky M, Marshall KA, Phillippy KH, Sherman PM, Muertter RN, Holko M, Ayanbule O, Yefanov A, Soboleva A (January 2011).
1062:, is a protein coding gene that encodes a single pass membrane protein, known to participate in developmental regulation and cellular communication. It is located on chromosome 19 at the 49th
3971:
Victorine AS, Weida J, Hines KA, Robinson B, Torres-Martinez W, Weaver DD (March 2014). "Prenatal diagnosis of
Carpenter syndrome: looking beyond craniosynostosis and polysyndactyly".
4053:
Nakayama M, Nakajima D, Nagase T, Nomura N, Seki N, Ohara O (July 1998). "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening".
273:
172:
1989:
2190:
1737:
Epidermal Growth Factor Domain: a short peptide with a distinctive motif of six cysteines, which is found in many different proteins of diverse functions
784:
95:
765:
1805:
1073:
2636:
for more extensive details related to the disease. Genetic mutations in MEGF8 have been found to be a principal cause of this rare genetic syndrome.
2222:
Analysis of gene ontology information by BioGPS was able to produce a list of biological processes in each of which MEGF8 plays a significant role:
42:
3141:
Nakai K, Horton P (January 1999). "PSORT: a program for detecting sorting signals in proteins and predicting their subcellular localization".
2768:
4233:
1077:
3889:
Frias JL, Felman AH, Rosenbloom AL, Finkelstein SN, Hoyt WF, Hall BD (1978). "Normal intelligence in two children with
Carpenter syndrome".
3629:
Lane L, Argoud-Puy G, Britan A, Cusin I, Duek PD, Evalet O, Gateau A, Gaudet P, Gleizes A, Masselot A, Zwahlen C, Bairoch A (January 2012).
2750:
3728:
Jensen LJ, Kuhn M, Stark M, Chaffron S, Creevey C, Muller J, Doerks T, Julien P, Roth A, Simonovic M, Bork P, von Mering C (January 2009).
2214:
According to BioGPS gene ontology information, MEGF8 is an active participant in receptor activity, calcium ion binding, protein binding.
3289:
Blom N, Gammeltoft S, Brunak S (December 1999). "Sequence and structure-based prediction of eukaryotic protein phosphorylation sites".
2483:
Plays a role in ATP dependent nucleosome remodeling by SMARCA4 containing complexes. Stimulates nuclear receptor mediated transcription
259:
996:
2394:
Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation
1003:
236:
3066:
2737:
2716:
158:
133:
2733:
1639:
Activator-, mediator- and TBP-dependent core promoter element for RNA polymerase II transcription from TATA-less promoters
1538:
2712:
2574:
The four primary splice variants and their distinctions are described below (labels correspond to those in image below):
2189:
MEGF8 is found to be expressed at high levels in cardiac myocytes and fetal brain tissue, according to GeoProfiles, from
75:
4128:"Mutations in multidomain protein MEGF8 identify a Carpenter syndrome subtype associated with defective lateralization"
3837:"Mutations in multidomain protein MEGF8 identify a Carpenter syndrome subtype associated with defective lateralization"
1703:
272:
171:
1208:
3406:
Bendtsen JD, Nielsen H, von Heijne G, Brunak S (July 2004). "Improved prediction of signal peptides: SignalP 3.0".
1318:
1743:: contains several sub-families of different functions according to location and protein; not specified for MEGF8.
265:
164:
1756:: Galactose oxidase, central domain; Found to cause formation of ß propeller tertiary structure of the protein.
1384:
829:
83:
3578:
Wu C, Orozco C, Boyer J, Leglise M, Goodale J, Batalov S, Hodge CL, Haase J, Janes J, Huss JW, Su AI (2009).
3361:"Prediction of post-translational glycosylation and phosphorylation of proteins from the amino acid sequence"
4238:
4008:
Engelhard C, Sarsfield S, Merte J, Wang Q, Li P, Beppu H, Kolodkin AL, Sucov HM, Ginty DD (September 2013).
1625:
promoter region through Genomatix. The top twenty most confidently predicted factors include the following:
1230:
810:
66:, C19orf49, CRPT2, EGFL4, SBP1, Multiple Epidermal Growth Factor-like Domains 8, multiple EGF like domains 8
2196:
510:
3415:
1560:
1428:
1068:
147:
2105:
56; 223; 267; 427; 699; 749; 968; 987; 1054; 1140; 1210; 1539; 1908; 1929; 2006; 2153; 2168; 2340; 2778
1601:
4172:"Massively parallel sequencing identifies the gene Megf8 with ENU-induced mutation causing heterotaxy"
2789:"Massively parallel sequencing identifies the gene Megf8 with ENU-induced mutation causing heterotaxy"
1959:
4183:
3580:"BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources"
3453:"Advantages of combined transmembrane topology and signal peptide prediction--the Phobius web server"
2888:
2800:
3420:
2605:
62:
1186:
979:
954:
928:
903:
1142:
1072:
transmembrane protein, with several of the same key features and motifs as MEGF8, as indicated by
3996:
3388:
2633:
2473:
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member (
1494:
1362:
1340:
1296:
1082:
1063:
107:
958:
907:
899:
1164:
4211:
4157:
4113:
4070:
4041:
3988:
3949:
3906:
3866:
3811:
3759:
3710:
3660:
3611:
3557:
3482:
3433:
3380:
3341:
3306:
3256:
3207:
3158:
3123:
3096:
3039:
2916:
2828:
1993:
1252:
55:
2609:
This diagram from AceView depicts the various forms of MEGF8 produced by alternative splicing
4201:
4191:
4147:
4139:
4103:
4095:
4062:
4031:
4021:
3980:
3941:
3898:
3856:
3848:
3801:
3793:
3777:
3749:
3741:
3700:
3692:
3650:
3642:
3601:
3591:
3547:
3539:
3472:
3464:
3425:
3372:
3333:
3298:
3246:
3238:
3197:
3189:
3150:
3086:
3078:
3029:
3021:
3009:
3005:
2906:
2896:
2818:
2808:
2651:
1716:
352:
283:
227:
182:
2846:
1621:
More than one hundred transcription factor binding sites were predicted to be found in the
103:
41:
3176:
Andreeva A, Howorth D, Chandonia JM, Brenner SE, Hubbard TJ, Chothia C, Murzin AG (2008).
1887:
241-276; 340-388; 454-504; 519-575; 1450-1492; 1505-1552; 1724-1764; 1780-1820; 2239-2255
1766:
1747:
1740:
1698:
1605:
1450:
327:
2877:"SMART, a simple modular architecture research tool: identification of signaling domains"
4187:
3730:"STRING 8--a global view on proteins and their functional interactions in 630 organisms"
3274:
Gramatikoff K, et al. (2004). "In Frontiers of Biotechnology and Pharmaceuticals".
2892:
2804:
4206:
4171:
4152:
4127:
4108:
4083:
4036:
4009:
3861:
3836:
3806:
3781:
3754:
3729:
3705:
3680:
3655:
3630:
3606:
3579:
3552:
3527:
3477:
3452:
3251:
3226:
3202:
3177:
3091:
2823:
2788:
2672:
1981:
1759:
1734:: extracellular domain: present in proteins mostly known to be involved in development.
1472:
3154:
699:
694:
689:
684:
679:
674:
669:
664:
659:
654:
649:
644:
639:
634:
629:
624:
619:
614:
609:
604:
588:
583:
578:
573:
557:
552:
4227:
3337:
2911:
2876:
1516:
539:
3392:
2007:
Table 3: Key Predicted Post Translational Modifications Found in MEGF8 Human Protein
87:
4000:
3500:
3324:
Karlin S (June 1995). "Statistical significance of sequence patterns in proteins".
1800:
Table 2: Predicted Key Features, Domains, & Motifs Found in MEGF8 Human Protein
1274:
345:
124:
3227:"DISULFIND: a disulfide bonding state and cysteine connectivity prediction server"
111:
2773:
National Center for Biotechnology Information, U.S. National Library of Medicine
2755:
National Center for Biotechnology Information, U.S. National Library of Medicine
2678:
1985:
1753:
1706:
of 20 orthologs, were found to be located in the CUB and transmembrane domains.
1406:
4176:
Proceedings of the National Academy of Sciences of the United States of America
4143:
4099:
3852:
3596:
2881:
Proceedings of the National Academy of Sciences of the United States of America
2793:
Proceedings of the National Academy of Sciences of the United States of America
428:
3429:
3010:"Protein structure prediction on the web: a case study using the Phyre server"
1777:
1731:
244:
141:
91:
4196:
3945:
3902:
3067:"CDD: a Conserved Domain Database for the functional annotation of proteins"
2901:
2813:
2248:
positive regulation of axon extension involved in axon guidance (GO:0048842)
1608:), a gene promoter database, predicted ten different possible promoters for
729:
488:
366:
311:
298:
210:
197:
99:
4215:
4161:
4117:
4066:
4045:
3992:
3870:
3815:
3763:
3714:
3664:
3615:
3561:
3486:
3437:
3384:
3376:
3310:
3302:
3260:
3211:
3162:
3100:
3043:
3034:
2832:
2588:
CUB). Still has signal and TMEM so may still be able to partially function
1967:
4074:
3953:
3797:
3696:
3646:
3543:
3345:
3127:
3114:
Davis CG (May 1990). "The many faces of epidermal growth factor repeats".
3082:
2934:
2920:
1992:. SCOP also indicated that the beta-propeller in MEGF8 is a member of the
1043:
1038:
3984:
3910:
3745:
3468:
3359:
Blom N, Sicheritz-Pontén T, Gupta R, Gammeltoft S, Brunak S (June 2004).
3242:
3193:
3025:
1808:
for the Human MEGF8 Sequence, with the NCBI accession number BAA32469.2.
1781:
1027:
874:
855:
4026:
1980:
One of the key attributes of MEGF8's tertiary structure is its 7-bladed
2983:
2956:
2474:
2251:
epiboly involved in gastrulation with mouth forming second (GO:0055113)
841:
796:
2444:
1785:
1773:
1011:
751:
17:
4010:"MEGF8 is a modifier of BMP signaling in trigeminal sensory neurons"
3501:"MEGF8 - Large-scale analysis of the human transcriptome (HG-U133A)"
1642:
Chorion-specific transcription factors with a GCM DNA binding domain
3178:"Data growth and its impact on the SCOP database: new developments"
3528:"NCBI GEO: archive for functional genomics data sets--10 years on"
2604:
2414:
2355:
2263:
determination of digestive tract left/right asymmetry (GO:0071907)
2195:
1966:
1958:
2443:
Calcium Channel, Voltage-Dependent, P/Q Type, Alpha 1A Subunit (
1762:: A motif found in regulatory proteins, as predicted by PSORT II
714:
710:
2385:
1988:
found in its D1k3ia3 structural domain, which was identified by
79:
2870:
2868:
1678:
EGR/nerve growth factor induced protein C & related factors
635:
positive regulation of axon extension involved in axon guidance
519:
2254:
embryonic heart tube left/right pattern formation (GO:0060971)
3829:
3827:
3825:
3573:
3571:
1865:
148-177; 180-210; 1057-1100; 2121-2160; 2162-2190; 2200-2240
1909:
787-839; 889-931; 945-1013; 1864-1919; 2008-2058; 2060-2117
1613:
overlaps with the transcriptional start codon in the gene.
1598:
3884:
3882:
3880:
610:
epiboly involved in gastrulation with mouth forming second
2565:
Alternative Splicing, Mutations, & Phenotypic Impacts
2358:
is a growth factor independent 1B transcription repressor
3225:
Ceroni A, Passerini A, Vullo A, Frasconi P (July 2006).
2286:
Table 4: Putative Protein Interactions with Human MEGF8
2260:
determination of heart left/right asymmetry (GO:0061371)
335:
2847:"Multiple Epidermal Growth Factor-like Domains 8 Gene"
2200:
NCBI GeoProfile for MEGF8 Tissues Expression in Humans
2875:
Schultz J, Milpetz F, Bork P, Ponting CP (May 1998).
630:
determination of digestive tract left/right asymmetry
500:
2245:
embryonic skeletal system morphogenesis (GO:0048704)
2242:
cell migration involved in gastrulation (GO:0042074)
3681:"The IntAct molecular interaction database in 2012"
3631:"neXtProt: a knowledge platform for human proteins"
2595:TMEM to place in membrane so not a normal function
1971:
Human ATRNL1 (Paralog to MEGF8) Protein Feature Map
972:
947:
921:
892:
690:
negative regulation of smoothened signaling pathway
3780:, Ostell J, Pruitt KD, Tatusova T (January 2011).
2729:
2727:
2725:
2708:
2706:
2704:
2269:fasciculation of sensory neuron axon (GO:0097155)
625:embryonic heart tube left/right pattern formation
282:
181:
3782:"Entrez Gene: gene-centered information at NCBI"
2963:. Department of Mathematics, Stanford University
1645:Signal transducer and activator of transcription
2666:Obesity in later life *congenital heart disease
2227:embryonic heart tube morphogenesis (GO:0003143)
1060:Multiple Epidermal Growth Factor-like Domains 8
27:Protein-coding gene in the species Homo sapiens
3926:
3924:
3922:
3920:
2734:GRCm38: Ensembl release 89: ENSMUSG00000045039
2266:craniofacial suture morphogenesis (GO:0097094)
2361:Two-Hybrid (IntAct) Text-mining (STRING/OMIM)
2205:Function and Mechanisms in Cellular Processes
8:
3973:American Journal of Medical Genetics. Part A
3451:Käll L, Krogh A, Sonnhammer EL (July 2007).
2713:GRCh38: Ensembl release 89: ENSG00000105429
1931:1103-1148; 1346-1485; 2244-2317; 2320-2381
615:determination of heart left/right asymmetry
2230:regulation of gene expression (GO:0010468)
2001:Predicted Post Translational Modifications
1963:Scaled Map of MEGF8 Features along protein
1660:Neuron-specific olfactory factor (2 sites)
725:
535:
323:
222:
119:
4205:
4195:
4151:
4107:
4035:
4025:
3860:
3805:
3753:
3704:
3654:
3605:
3595:
3551:
3476:
3419:
3250:
3201:
3090:
3033:
2910:
2900:
2853:. Weizmann Institute of Science in Israel
2822:
2812:
2257:left/right pattern formation (GO:0060972)
2233:embryonic limb morphogenesis (GO:0030326)
1806:Simple Modular Architecture Research Tool
1074:Simple Modular Architecture Research Tool
2700:
2413:Apinocerebellar ataxia type 7 protein (
680:cell migration involved in gastrulation
605:embryonic skeletal system morphogenesis
2480:Text-mining (OMIM article for SMARCS3)
1794:Predicted Domain & Motif Locations
1633:Vertebrate TATA binding protein factor
31:
3326:Current Opinion in Structural Biology
1078:European Molecular Biology Laboratory
287:
248:
243:
186:
145:
140:
7:
4084:"BMP signaling in axon regeneration"
3934:American Journal of Medical Genetics
3891:American Journal of Medical Genetics
2581:splice model of the analyzed megf8.
2352:Found in Endothelial & Erythroid
1859:Epidermal Growth Factor (EGF) Domain
1722:Predicted Key Domains & Features
1672:Nuclear receptor subfamily 2 factors
685:fasciculation of sensory neuron axon
655:determination of left/right symmetry
459:vestibular membrane of cochlear duct
3008:, Sternberg MJ (26 February 2009).
2984:"PELE-Protein Structure Prediction"
2043:Cysteine involved in Disulfide Bond
1589:any birds, and only one amphibian.
4132:American Journal of Human Genetics
3841:American Journal of Human Genetics
2236:BMP signaling pathway (GO:0030509)
2029:Amino Acid Location Range (1-2785)
1997:do not support these predictions.
1830:Amino Acid Location Range (1-2785)
1681:Neuron-restrictive silencer factor
1657:KRAB domain zinc finger protein 57
969:
944:
918:
889:
865:
846:
820:
801:
775:
756:
665:embryonic heart tube morphogenesis
505:
423:
361:
340:
25:
650:craniofacial suture morphogenesis
2091:CQCNGH 1144-1149 & 2313-2318
640:coronary vasculature development
509:
271:
264:
258:
235:
170:
163:
157:
132:
40:
4088:Current Opinion in Neurobiology
2640:Adverse Phenotypic Consequences
2239:limb morphogenesis (GO:0035108)
1816:Feature, Domain, or Motif Name
1076:(SMART) which is hosted by the
4082:Zhong J, Zou H (August 2014).
3143:Trends in Biochemical Sciences
2295:Predicted Interacting Protein
1630:Ccaat/Enhancer Binding Protein
1209:Trichechus manatus latirostris
1099:sequence identity decreased.
574:integral component of membrane
520:More reference expression data
489:More reference expression data
405:right hemisphere of cerebellum
1:
3463:(Web Server issue): W429–32.
3237:(Web Server issue): W177–81.
3155:10.1016/S0968-0004(98)01336-X
2119:between amino acids 34 and 35
1772:PSI domain: domain found in
1666:RXR heterodimer binding sites
1539:Strongylocentrotus purpuratus
670:regulation of gene expression
256:
155:
4234:Genes on human chromosome 19
3538:(Database issue): D1005–10.
3408:Journal of Molecular Biology
3338:10.1016/0959-440X(95)80098-0
3291:Journal of Molecular Biology
2957:"Statistical Analysis of PS"
2218:Role in Biological Processes
1663:Nuclear respiratory factor 1
1648:Heat shock factors (2 sites)
675:left/right pattern formation
660:embryonic limb morphogenesis
3188:(Database issue): D419–25.
2450:Two Hybrid Assay, Pull-Down
2282:
2004:
1797:
1704:multiple sequence alignment
1101:
4255:
4144:10.1016/j.ajhg.2012.08.027
4100:10.1016/j.conb.2014.03.009
3853:10.1016/j.ajhg.2012.08.027
3740:(Database issue): D412–6.
3691:(Database issue): D841–6.
3641:(Database issue): D76–83.
3597:10.1186/gb-2009-10-11-r130
3077:(Database issue): D225–9.
3065:Bryant SH (January 2011).
1654:Estrogen response elements
1319:Alligator mississippiensis
695:animal organ morphogenesis
3792:(Database issue): D52–7.
3430:10.1016/j.jmb.2004.05.028
2769:"Mouse PubMed Reference:"
2751:"Human PubMed Reference:"
2368:IntAct, STRING, NextProt
2323:Experimental/Text Support
2022:Number Predicted in MEGF8
1804:Found through the use of
1094:Evolution & Orthologs
1042:
1037:
1033:
1026:
1010:
991:
976:
951:
940:
925:
896:
885:
872:
868:
853:
849:
840:
827:
823:
808:
804:
795:
782:
778:
763:
759:
750:
735:
728:
724:
708:
538:
534:
517:
508:
499:
486:
435:
426:
373:
364:
334:
326:
322:
305:
292:
255:
234:
225:
221:
204:
191:
154:
131:
122:
118:
73:
70:
60:
53:
48:
39:
34:
2986:. SDSC Biology Workbench
2052:DISULFIND & UniProt
1870:D1k3ia Structural Domain
1599:http://www.genomatix.de/
1385:Neolamprologus brichardi
1104:Table 1: MEGF8 Orthologs
997:Chr 19: 42.33 – 42.38 Mb
463:Rostral migratory stream
389:tendon of biceps brachii
4197:10.1073/pnas.0813400106
3946:10.1002/ajmg.1320280208
3903:10.1002/ajmg.1320020210
2902:10.1073/pnas.95.11.5857
2814:10.1073/pnas.0813400106
2113:Signal Peptide Cleavage
1984:which is formed by the
1675:Octamer binding protein
1499:Mediterranean Fruit Fly
1231:Leptonychotes weddellii
1004:Chr 7: 25.02 – 25.07 Mb
467:external carotid artery
451:internal carotid artery
4067:10.1006/geno.1998.5341
3786:Nucleic Acids Research
3734:Nucleic Acids Research
3685:Nucleic Acids Research
3635:Nucleic Acids Research
3532:Nucleic Acids Research
3457:Nucleic Acids Research
3377:10.1002/pmic.200300771
3303:10.1006/jmbi.1999.3310
3231:Nucleic Acids Research
3182:Nucleic Acids Research
3071:Nucleic Acids Research
2610:
2201:
2099:N-linked Glycosylation
1972:
1964:
1892:Leucine Zipper Pattern
1597:Genomatix's ElDorado (
1561:Nematostella vectensis
409:superior frontal gyrus
2660:Polysyndactyly Digits
2608:
2524:(Q8CKF8 in UniProtKB)
2440:Certain Brain Tissues
2420:Two Hybrid, Pull-Down
2275:Putative Interactions
2199:
2164:Phobius, SAPS, SMART
1970:
1962:
1651:GC-Box factors SP1/GC
1636:CCAAT binding factors
1617:Transcription Factors
645:BMP signaling pathway
584:extracellular exosome
397:primary visual cortex
377:middle temporal gyrus
148:Chromosome 19 (human)
3985:10.1002/ajmg.a.36362
3026:10.1038/nprot.2009.2
2650:Tower-shaped skull (
2628:Carpenter Syndrome 2
2169:Intracellular Domain
2155:Transmembrane Region
2141:Extracellular Domain
1947:Transmembrane Region
1687:Protein Architecture
1669:GATA binding factors
1429:IIctalurus punctatus
1116:Organism Common Name
250:Chromosome 7 (mouse)
4188:2009PNAS..106.3219Z
4027:10.7554/eLife.01160
3798:10.1093/nar/gkq1237
3697:10.1093/nar/gkr1088
3647:10.1093/nar/gkr1179
3544:10.1093/nar/gkq1184
3083:10.1093/nar/gkq1189
2893:1998PNAS...95.5857S
2805:2009PNAS..106.3219Z
2410:Mod-High Everywhere
2289:
2009:
1876:233-550; 1449-1801
1810:
1710:Secondary Structure
1565:Starlet Sea Anemone
1367:Western clawed frog
1131:Sequence Similarity
1106:
1067:303.1 kdal. Using
553:calcium ion binding
3746:10.1093/nar/gkn760
3469:10.1093/nar/gkm256
3243:10.1093/nar/gkl266
3194:10.1093/nar/gkm993
2657:Mental Retardation
2634:Carpenter syndrome
2611:
2550:Two Hybrid Pooling
2527:Two Hybrid Pooling
2503:Two Hybrid Pooling
2427:Int Act, NextProt
2283:
2210:Molecular Function
2202:
2127:Hydrophobic Domain
2063:K886; K1681; K1737
2046:99+ Possible Sites
2005:
1976:Tertiary Structure
1973:
1965:
1798:
1604:2021-12-02 at the
1495:Ceratitis capitata
1455:Japanese Rice Fish
1363:Xenopus tropicalis
1341:Alligator sinensis
1323:American Alligator
1297:Ophiophagus hannah
1102:
1083:Carpenter syndrome
1064:open reading frame
830:ENSMUSG00000045039
700:tissue development
620:limb morphogenesis
598:Biological process
567:Cellular component
546:Molecular function
475:supraoptic nucleus
471:epithelium of lens
385:right frontal lobe
3116:The New Biologist
2663:High birth weight
2562:
2561:
2556:IntAct, NextProt
2533:IntAct, NextProt
2509:IntAct, NextProt
2457:IntAct, NextProt
2182:
2181:
1994:galactose oxidase
1957:
1956:
1809:
1692:Primary Structure
1581:
1580:
1543:Purple Sea Urchin
1521:Common Water Flea
1477:Western Honey Bee
1345:Chinese alligator
1253:Rattus norvegicus
1126:Sequence Identity
1053:
1052:
1049:
1048:
1022:
1021:
987:
986:
966:
965:
936:
935:
915:
914:
881:
880:
862:
861:
836:
835:
817:
816:
791:
790:
772:
771:
720:
719:
530:
529:
526:
525:
495:
494:
482:
481:
420:
419:
401:entorhinal cortex
381:prefrontal cortex
318:
317:
217:
216:
112:MEGF8 - orthologs
16:(Redirected from
4246:
4219:
4209:
4199:
4165:
4155:
4121:
4111:
4078:
4049:
4039:
4029:
4004:
3958:
3957:
3928:
3915:
3914:
3886:
3875:
3874:
3864:
3831:
3820:
3819:
3809:
3774:
3768:
3767:
3757:
3725:
3719:
3718:
3708:
3675:
3669:
3668:
3658:
3626:
3620:
3619:
3609:
3599:
3575:
3566:
3565:
3555:
3523:
3517:
3516:
3514:
3512:
3497:
3491:
3490:
3480:
3448:
3442:
3441:
3423:
3403:
3397:
3396:
3356:
3350:
3349:
3321:
3315:
3314:
3286:
3280:
3279:
3271:
3265:
3264:
3254:
3222:
3216:
3215:
3205:
3173:
3167:
3166:
3138:
3132:
3131:
3111:
3105:
3104:
3094:
3061:
3055:
3054:
3052:
3050:
3037:
3014:Nature Protocols
3002:
2996:
2995:
2993:
2991:
2979:
2973:
2972:
2970:
2968:
2952:
2946:
2945:
2943:
2941:
2931:
2925:
2924:
2914:
2904:
2872:
2863:
2862:
2860:
2858:
2843:
2837:
2836:
2826:
2816:
2783:
2777:
2776:
2765:
2759:
2758:
2747:
2741:
2731:
2720:
2710:
2687:Current Research
2669:Umbilical hernia
2652:craniosynostosis
2614:Common Mutations
2540:
2516:
2493:
2464:
2434:
2404:
2391:Two Hybrid Assay
2375:
2346:
2290:
2085:Internal Repeats
2010:
1811:
1802:
1147:Pygmy Chimpanzee
1121:Accession Number
1107:
1035:
1034:
1006:
999:
982:
970:
961:
945:
941:RefSeq (protein)
931:
919:
910:
890:
866:
847:
821:
802:
776:
757:
726:
536:
522:
513:
506:
491:
431:
429:Top expressed in
424:
369:
367:Top expressed in
362:
341:
324:
314:
301:
290:
275:
268:
262:
251:
239:
223:
213:
200:
189:
174:
167:
161:
150:
136:
120:
114:
65:
58:
44:
32:
21:
4254:
4253:
4249:
4248:
4247:
4245:
4244:
4243:
4224:
4223:
4222:
4168:
4124:
4081:
4052:
4007:
3970:
3966:
3964:Further reading
3961:
3930:
3929:
3918:
3888:
3887:
3878:
3833:
3832:
3823:
3776:
3775:
3771:
3727:
3726:
3722:
3677:
3676:
3672:
3628:
3627:
3623:
3577:
3576:
3569:
3525:
3524:
3520:
3510:
3508:
3499:
3498:
3494:
3450:
3449:
3445:
3421:10.1.1.165.2784
3405:
3404:
3400:
3358:
3357:
3353:
3323:
3322:
3318:
3288:
3287:
3283:
3273:
3272:
3268:
3224:
3223:
3219:
3175:
3174:
3170:
3140:
3139:
3135:
3113:
3112:
3108:
3063:
3062:
3058:
3048:
3046:
3004:
3003:
2999:
2989:
2987:
2981:
2980:
2976:
2966:
2964:
2954:
2953:
2949:
2939:
2937:
2933:
2932:
2928:
2887:(11): 5857–64.
2874:
2873:
2866:
2856:
2854:
2851:MEGF8 Gene Card
2845:
2844:
2840:
2785:
2784:
2780:
2767:
2766:
2762:
2749:
2748:
2744:
2732:
2723:
2711:
2702:
2698:
2689:
2684:
2642:
2630:
2621:
2616:
2572:
2570:Splice Variants
2567:
2553:Uncharacterized
2538:
2530:Uncharacterized
2514:
2506:Uncharacterized
2491:
2470:High Everywhere
2462:
2432:
2402:
2397:IntAct, STRING
2373:
2344:
2288:
2277:
2272:
2220:
2212:
2207:
2187:
2178:Phobius, SMART
2071:Phosphorylation
2060:3 (confidently)
2003:
1978:
1925:EGF_Like Domain
1823:Number in MEGF8
1803:
1796:
1767:EGF-like domain
1748:EGF-like domain
1741:EGF-like domain
1724:
1712:
1699:disulfide bonds
1694:
1689:
1684:
1619:
1606:Wayback Machine
1595:
1586:
1451:Oryzias latipes
1433:Channel Catfish
1389:African Cichlid
1213:Florida Manatee
1096:
1091:
1044:View/Edit Mouse
1039:View/Edit Human
1002:
995:
992:Location (UCSC)
978:
957:
953:
927:
906:
902:
898:
811:ENSG00000105429
704:
593:
562:
558:protein binding
518:
487:
478:
473:
469:
465:
461:
457:
455:ascending aorta
453:
449:
445:
441:
427:
416:
411:
407:
403:
399:
395:
391:
387:
383:
379:
365:
309:
296:
288:
278:
277:
276:
269:
249:
226:Gene location (
208:
195:
187:
177:
176:
175:
168:
146:
123:Gene location (
74:
61:
54:
28:
23:
22:
15:
12:
11:
5:
4252:
4250:
4242:
4241:
4239:Kelch proteins
4236:
4226:
4225:
4221:
4220:
4182:(9): 3219–24.
4166:
4138:(5): 897–905.
4122:
4079:
4050:
4005:
3967:
3965:
3962:
3960:
3959:
3916:
3876:
3847:(5): 897–905.
3821:
3769:
3720:
3670:
3621:
3584:Genome Biology
3567:
3518:
3492:
3443:
3398:
3371:(6): 1633–49.
3351:
3316:
3297:(5): 1351–62.
3281:
3266:
3217:
3168:
3133:
3106:
3056:
3020:(3): 363–371.
2997:
2982:Pappas Jr GJ.
2974:
2947:
2926:
2864:
2838:
2799:(9): 3219–24.
2778:
2760:
2742:
2721:
2699:
2697:
2694:
2688:
2685:
2683:
2682:
2681:("knock-knee")
2676:
2673:Cryptorchidism
2670:
2667:
2664:
2661:
2658:
2655:
2647:
2641:
2638:
2629:
2626:
2620:
2617:
2615:
2612:
2571:
2568:
2566:
2563:
2560:
2559:
2557:
2554:
2551:
2548:
2546:
2544:
2541:
2535:
2534:
2531:
2528:
2525:
2522:
2520:
2517:
2511:
2510:
2507:
2504:
2501:
2499:
2497:
2494:
2488:
2487:
2484:
2481:
2478:
2471:
2468:
2465:
2459:
2458:
2455:
2451:
2448:
2441:
2438:
2435:
2429:
2428:
2425:
2421:
2418:
2411:
2408:
2405:
2399:
2398:
2395:
2392:
2389:
2382:
2379:
2376:
2370:
2369:
2366:
2362:
2359:
2353:
2350:
2347:
2341:
2340:
2333:
2326:
2319:
2312:
2305:
2298:
2284:
2276:
2273:
2271:
2270:
2267:
2264:
2261:
2258:
2255:
2252:
2249:
2246:
2243:
2240:
2237:
2234:
2231:
2228:
2224:
2219:
2216:
2211:
2208:
2206:
2203:
2186:
2183:
2180:
2179:
2176:
2173:
2170:
2166:
2165:
2162:
2159:
2156:
2152:
2151:
2148:
2145:
2142:
2138:
2137:
2134:
2131:
2128:
2124:
2123:
2120:
2117:
2114:
2110:
2109:
2106:
2103:
2100:
2096:
2095:
2092:
2089:
2086:
2082:
2081:
2078:
2075:
2072:
2068:
2067:
2064:
2061:
2058:
2054:
2053:
2050:
2047:
2044:
2040:
2039:
2032:
2025:
2018:
2002:
1999:
1982:beta propeller
1977:
1974:
1955:
1954:
1951:
1948:
1944:
1943:
1940:
1937:
1936:EGF_LAM Domain
1933:
1932:
1929:
1926:
1922:
1921:
1918:
1915:
1911:
1910:
1907:
1904:
1900:
1899:
1896:
1893:
1889:
1888:
1885:
1882:
1878:
1877:
1874:
1871:
1867:
1866:
1863:
1860:
1856:
1855:
1852:
1849:
1845:
1844:
1841:
1838:
1837:Signal Peptide
1834:
1833:
1826:
1819:
1795:
1792:
1791:
1790:
1770:
1763:
1760:Leucine Zipper
1757:
1751:
1744:
1738:
1735:
1723:
1720:
1711:
1708:
1693:
1690:
1688:
1685:
1683:
1682:
1679:
1676:
1673:
1670:
1667:
1664:
1661:
1658:
1655:
1652:
1649:
1646:
1643:
1640:
1637:
1634:
1631:
1627:
1618:
1615:
1594:
1591:
1585:
1582:
1579:
1578:
1575:
1572:
1569:
1566:
1563:
1557:
1556:
1553:
1550:
1547:
1544:
1541:
1535:
1534:
1531:
1528:
1525:
1522:
1519:
1513:
1512:
1509:
1506:
1503:
1500:
1497:
1491:
1490:
1487:
1484:
1481:
1478:
1475:
1473:Apis mellifera
1469:
1468:
1465:
1462:
1459:
1456:
1453:
1447:
1446:
1443:
1440:
1437:
1434:
1431:
1425:
1424:
1421:
1418:
1415:
1412:
1409:
1403:
1402:
1399:
1396:
1393:
1390:
1387:
1381:
1380:
1377:
1374:
1371:
1368:
1365:
1359:
1358:
1355:
1352:
1349:
1346:
1343:
1337:
1336:
1333:
1330:
1327:
1324:
1321:
1315:
1314:
1311:
1308:
1305:
1302:
1299:
1293:
1292:
1289:
1286:
1283:
1282:NP_001153872.1
1280:
1277:
1271:
1270:
1267:
1264:
1261:
1258:
1255:
1249:
1248:
1245:
1242:
1239:
1236:
1233:
1227:
1226:
1223:
1220:
1217:
1214:
1211:
1205:
1204:
1201:
1198:
1195:
1192:
1189:
1183:
1182:
1179:
1176:
1173:
1170:
1167:
1161:
1160:
1157:
1154:
1151:
1148:
1145:
1139:
1138:
1133:
1128:
1123:
1118:
1113:
1095:
1092:
1090:
1087:
1058:also known as
1051:
1050:
1047:
1046:
1041:
1031:
1030:
1024:
1023:
1020:
1019:
1017:
1015:
1008:
1007:
1000:
993:
989:
988:
985:
984:
974:
973:
967:
964:
963:
949:
948:
942:
938:
937:
934:
933:
923:
922:
916:
913:
912:
894:
893:
887:
883:
882:
879:
878:
870:
869:
863:
860:
859:
851:
850:
844:
838:
837:
834:
833:
825:
824:
818:
815:
814:
806:
805:
799:
793:
792:
789:
788:
780:
779:
773:
770:
769:
761:
760:
754:
748:
747:
742:
737:
733:
732:
722:
721:
718:
717:
706:
705:
703:
702:
697:
692:
687:
682:
677:
672:
667:
662:
657:
652:
647:
642:
637:
632:
627:
622:
617:
612:
607:
601:
599:
595:
594:
592:
591:
586:
581:
576:
570:
568:
564:
563:
561:
560:
555:
549:
547:
543:
542:
532:
531:
528:
527:
524:
523:
515:
514:
503:
497:
496:
493:
492:
484:
483:
480:
479:
477:
476:
472:
468:
464:
460:
456:
452:
448:
444:
440:
436:
433:
432:
421:
418:
417:
415:
414:
410:
406:
402:
398:
394:
390:
386:
382:
378:
374:
371:
370:
358:
357:
349:
338:
332:
331:
328:RNA expression
320:
319:
316:
315:
307:
303:
302:
294:
291:
286:
280:
279:
270:
263:
257:
253:
252:
247:
241:
240:
232:
231:
219:
218:
215:
214:
206:
202:
201:
193:
190:
185:
179:
178:
169:
162:
156:
152:
151:
144:
138:
137:
129:
128:
116:
115:
72:
68:
67:
59:
51:
50:
46:
45:
37:
36:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
4251:
4240:
4237:
4235:
4232:
4231:
4229:
4217:
4213:
4208:
4203:
4198:
4193:
4189:
4185:
4181:
4177:
4173:
4167:
4163:
4159:
4154:
4149:
4145:
4141:
4137:
4133:
4129:
4123:
4119:
4115:
4110:
4105:
4101:
4097:
4093:
4089:
4085:
4080:
4076:
4072:
4068:
4064:
4060:
4056:
4051:
4047:
4043:
4038:
4033:
4028:
4023:
4019:
4015:
4011:
4006:
4002:
3998:
3994:
3990:
3986:
3982:
3978:
3974:
3969:
3968:
3963:
3955:
3951:
3947:
3943:
3940:(2): 311–24.
3939:
3935:
3927:
3925:
3923:
3921:
3917:
3912:
3908:
3904:
3900:
3896:
3892:
3885:
3883:
3881:
3877:
3872:
3868:
3863:
3858:
3854:
3850:
3846:
3842:
3838:
3830:
3828:
3826:
3822:
3817:
3813:
3808:
3803:
3799:
3795:
3791:
3787:
3783:
3779:
3773:
3770:
3765:
3761:
3756:
3751:
3747:
3743:
3739:
3735:
3731:
3724:
3721:
3716:
3712:
3707:
3702:
3698:
3694:
3690:
3686:
3682:
3674:
3671:
3666:
3662:
3657:
3652:
3648:
3644:
3640:
3636:
3632:
3625:
3622:
3617:
3613:
3608:
3603:
3598:
3593:
3589:
3585:
3581:
3574:
3572:
3568:
3563:
3559:
3554:
3549:
3545:
3541:
3537:
3533:
3529:
3522:
3519:
3506:
3502:
3496:
3493:
3488:
3484:
3479:
3474:
3470:
3466:
3462:
3458:
3454:
3447:
3444:
3439:
3435:
3431:
3427:
3422:
3417:
3414:(4): 783–95.
3413:
3409:
3402:
3399:
3394:
3390:
3386:
3382:
3378:
3374:
3370:
3366:
3362:
3355:
3352:
3347:
3343:
3339:
3335:
3332:(3): 360–71.
3331:
3327:
3320:
3317:
3312:
3308:
3304:
3300:
3296:
3292:
3285:
3282:
3277:
3276:Science Press
3270:
3267:
3262:
3258:
3253:
3248:
3244:
3240:
3236:
3232:
3228:
3221:
3218:
3213:
3209:
3204:
3199:
3195:
3191:
3187:
3183:
3179:
3172:
3169:
3164:
3160:
3156:
3152:
3148:
3144:
3137:
3134:
3129:
3125:
3121:
3117:
3110:
3107:
3102:
3098:
3093:
3088:
3084:
3080:
3076:
3072:
3068:
3060:
3057:
3045:
3041:
3036:
3035:10044/1/18157
3031:
3027:
3023:
3019:
3015:
3011:
3007:
3001:
2998:
2985:
2978:
2975:
2962:
2958:
2951:
2948:
2936:
2930:
2927:
2922:
2918:
2913:
2908:
2903:
2898:
2894:
2890:
2886:
2882:
2878:
2871:
2869:
2865:
2852:
2848:
2842:
2839:
2834:
2830:
2825:
2820:
2815:
2810:
2806:
2802:
2798:
2794:
2790:
2782:
2779:
2774:
2770:
2764:
2761:
2756:
2752:
2746:
2743:
2739:
2735:
2730:
2728:
2726:
2722:
2718:
2714:
2709:
2707:
2705:
2701:
2695:
2693:
2686:
2680:
2677:
2674:
2671:
2668:
2665:
2662:
2659:
2656:
2653:
2649:
2648:
2646:
2639:
2637:
2635:
2627:
2625:
2618:
2613:
2607:
2603:
2600:
2596:
2593:
2589:
2586:
2582:
2579:
2575:
2569:
2564:
2558:
2555:
2552:
2549:
2547:
2545:
2542:
2537:
2536:
2532:
2529:
2526:
2523:
2521:
2518:
2513:
2512:
2508:
2505:
2502:
2500:
2498:
2495:
2490:
2489:
2485:
2482:
2479:
2476:
2472:
2469:
2466:
2461:
2460:
2456:
2452:
2449:
2446:
2442:
2439:
2436:
2431:
2430:
2426:
2424:stabilization
2422:
2419:
2416:
2412:
2409:
2406:
2401:
2400:
2396:
2393:
2390:
2387:
2383:
2380:
2377:
2372:
2371:
2367:
2363:
2360:
2357:
2354:
2351:
2348:
2343:
2342:
2339:
2338:
2334:
2332:
2331:
2327:
2325:
2324:
2320:
2318:
2317:
2313:
2311:
2310:
2306:
2304:
2303:
2299:
2297:
2296:
2292:
2291:
2287:
2281:
2274:
2268:
2265:
2262:
2259:
2256:
2253:
2250:
2247:
2244:
2241:
2238:
2235:
2232:
2229:
2226:
2225:
2223:
2217:
2215:
2209:
2204:
2198:
2194:
2192:
2184:
2177:
2174:
2171:
2168:
2167:
2163:
2160:
2157:
2154:
2153:
2149:
2146:
2143:
2140:
2139:
2135:
2132:
2129:
2126:
2125:
2121:
2118:
2115:
2112:
2111:
2107:
2104:
2101:
2098:
2097:
2093:
2090:
2087:
2084:
2083:
2079:
2076:
2073:
2070:
2069:
2065:
2062:
2059:
2056:
2055:
2051:
2048:
2045:
2042:
2041:
2038:
2037:
2033:
2031:
2030:
2026:
2024:
2023:
2019:
2017:
2016:
2012:
2011:
2008:
2000:
1998:
1995:
1991:
1987:
1983:
1975:
1969:
1961:
1952:
1949:
1946:
1945:
1941:
1938:
1935:
1934:
1930:
1927:
1924:
1923:
1919:
1916:
1914:EGF_Ca Domain
1913:
1912:
1908:
1905:
1902:
1901:
1897:
1894:
1891:
1890:
1886:
1883:
1880:
1879:
1875:
1872:
1869:
1868:
1864:
1861:
1858:
1857:
1853:
1850:
1847:
1846:
1842:
1839:
1836:
1835:
1832:
1831:
1827:
1825:
1824:
1820:
1818:
1817:
1813:
1812:
1807:
1801:
1793:
1787:
1783:
1779:
1775:
1771:
1768:
1764:
1761:
1758:
1755:
1752:
1749:
1745:
1742:
1739:
1736:
1733:
1730:
1729:
1728:
1721:
1719:
1718:
1709:
1707:
1705:
1700:
1691:
1686:
1680:
1677:
1674:
1671:
1668:
1665:
1662:
1659:
1656:
1653:
1650:
1647:
1644:
1641:
1638:
1635:
1632:
1629:
1628:
1626:
1624:
1616:
1614:
1611:
1607:
1603:
1600:
1592:
1590:
1583:
1576:
1573:
1570:
1567:
1564:
1562:
1559:
1558:
1554:
1551:
1548:
1545:
1542:
1540:
1537:
1536:
1532:
1529:
1526:
1523:
1520:
1518:
1517:Daphnia pulex
1515:
1514:
1510:
1507:
1504:
1501:
1498:
1496:
1493:
1492:
1488:
1485:
1482:
1479:
1476:
1474:
1471:
1470:
1466:
1463:
1460:
1457:
1454:
1452:
1449:
1448:
1444:
1441:
1438:
1435:
1432:
1430:
1427:
1426:
1422:
1419:
1416:
1413:
1410:
1408:
1405:
1404:
1400:
1397:
1394:
1391:
1388:
1386:
1383:
1382:
1378:
1375:
1372:
1369:
1366:
1364:
1361:
1360:
1356:
1353:
1350:
1347:
1344:
1342:
1339:
1338:
1334:
1331:
1328:
1325:
1322:
1320:
1317:
1316:
1312:
1309:
1306:
1303:
1300:
1298:
1295:
1294:
1290:
1287:
1284:
1281:
1278:
1276:
1273:
1272:
1268:
1265:
1262:
1259:
1256:
1254:
1251:
1250:
1246:
1243:
1240:
1237:
1234:
1232:
1229:
1228:
1224:
1221:
1218:
1215:
1212:
1210:
1207:
1206:
1202:
1199:
1196:
1193:
1190:
1188:
1187:Orcinius Orca
1185:
1184:
1180:
1177:
1174:
1171:
1168:
1166:
1163:
1162:
1158:
1155:
1152:
1149:
1146:
1144:
1141:
1140:
1137:
1134:
1132:
1129:
1127:
1124:
1122:
1119:
1117:
1114:
1112:
1111:Genus/Species
1109:
1108:
1105:
1100:
1093:
1088:
1086:
1084:
1079:
1075:
1070:
1065:
1061:
1057:
1045:
1040:
1036:
1032:
1029:
1025:
1018:
1016:
1013:
1009:
1005:
1001:
998:
994:
990:
983:
981:
975:
971:
968:
962:
960:
956:
950:
946:
943:
939:
932:
930:
924:
920:
917:
911:
909:
905:
901:
895:
891:
888:
886:RefSeq (mRNA)
884:
877:
876:
871:
867:
864:
858:
857:
852:
848:
845:
843:
839:
832:
831:
826:
822:
819:
813:
812:
807:
803:
800:
798:
794:
787:
786:
781:
777:
774:
768:
767:
762:
758:
755:
753:
749:
746:
743:
741:
738:
734:
731:
727:
723:
716:
712:
707:
701:
698:
696:
693:
691:
688:
686:
683:
681:
678:
676:
673:
671:
668:
666:
663:
661:
658:
656:
653:
651:
648:
646:
643:
641:
638:
636:
633:
631:
628:
626:
623:
621:
618:
616:
613:
611:
608:
606:
603:
602:
600:
597:
596:
590:
587:
585:
582:
580:
577:
575:
572:
571:
569:
566:
565:
559:
556:
554:
551:
550:
548:
545:
544:
541:
540:Gene ontology
537:
533:
521:
516:
512:
507:
504:
502:
498:
490:
485:
474:
470:
466:
462:
458:
454:
450:
446:
442:
439:otolith organ
438:
437:
434:
430:
425:
422:
413:parotid gland
412:
408:
404:
400:
396:
392:
388:
384:
380:
376:
375:
372:
368:
363:
360:
359:
356:
354:
350:
348:
347:
343:
342:
339:
337:
333:
329:
325:
321:
313:
308:
304:
300:
295:
285:
281:
274:
267:
261:
254:
246:
242:
238:
233:
229:
224:
220:
212:
207:
203:
199:
194:
184:
180:
173:
166:
160:
153:
149:
143:
139:
135:
130:
126:
121:
117:
113:
109:
105:
101:
97:
93:
89:
85:
81:
77:
69:
64:
57:
52:
47:
43:
38:
33:
30:
19:
4179:
4175:
4135:
4131:
4091:
4087:
4061:(1): 27–34.
4058:
4054:
4017:
4013:
3979:(3): 820–3.
3976:
3972:
3937:
3933:
3897:(2): 191–9.
3894:
3890:
3844:
3840:
3789:
3785:
3772:
3737:
3733:
3723:
3688:
3684:
3673:
3638:
3634:
3624:
3590:(11): R130.
3587:
3583:
3535:
3531:
3521:
3509:. Retrieved
3504:
3495:
3460:
3456:
3446:
3411:
3407:
3401:
3368:
3364:
3354:
3329:
3325:
3319:
3294:
3290:
3284:
3275:
3269:
3234:
3230:
3220:
3185:
3181:
3171:
3146:
3142:
3136:
3122:(5): 410–9.
3119:
3115:
3109:
3074:
3070:
3059:
3047:. Retrieved
3017:
3013:
3000:
2988:. Retrieved
2977:
2965:. Retrieved
2960:
2950:
2938:. Retrieved
2929:
2884:
2880:
2855:. Retrieved
2850:
2841:
2796:
2792:
2781:
2772:
2763:
2754:
2745:
2690:
2643:
2631:
2622:
2598:
2597:
2591:
2590:
2584:
2583:
2577:
2576:
2573:
2384:Atrophin 1 (
2336:
2335:
2329:
2328:
2322:
2321:
2315:
2314:
2308:
2307:
2301:
2300:
2294:
2293:
2285:
2278:
2221:
2213:
2188:
2035:
2034:
2028:
2027:
2021:
2020:
2014:
2013:
2006:
1979:
1881:Kelch Repeat
1829:
1828:
1822:
1821:
1815:
1814:
1799:
1725:
1713:
1695:
1622:
1620:
1609:
1596:
1587:
1568:XP_001635521
1480:XP_006568067
1458:XP_004078282
1414:XP_005158088
1392:XP_006808273
1370:XP_002936442
1348:XP_006038171
1326:XP_006273703
1275:Mus musculus
1238:XP_006748348
1235:Weddell Seal
1216:XP_004388865
1194:XP_004271289
1172:XP_005909034
1150:XP_003811808
1143:Pan Paniscus
1136:Length (AAs)
1135:
1130:
1125:
1120:
1115:
1110:
1103:
1097:
1059:
1055:
1054:
980:NP_001153872
977:
955:NP_001258867
952:
929:NM_001160400
926:
904:NM_001271938
897:
873:
854:
828:
809:
783:
764:
744:
739:
447:otic vesicle
393:frontal pole
351:
344:
71:External IDs
29:
3505:GeoProfiles
3149:(1): 34–6.
2955:Brendel V.
2679:Genu valgum
2543:Conf: 0.370
2519:Conf: 0.370
2496:Conf: 0.370
2467:Conf: 0.778
2437:Conf: 0.510
2407:Conf: 0.510
2378:Conf: 0.538
2316:Description
2057:SUMOylation
1986:kelch motif
1778:semaphorins
1754:Kelch motif
1407:Danio rerio
1260:NP_446080.1
1085:subtype 2.
310:25,065,342
297:25,016,589
289:7|7 A3
209:42,378,769
196:42,325,609
49:Identifiers
4228:Categories
4094:: 127–34.
4020:: e01160.
3365:Proteomics
2857:4 February
2740:, May 2017
2719:, May 2017
2696:References
2381:Everywhere
2349:Conf:0.866
2302:Confidence
2185:Expression
1953:2588-2610
1942:1151-1199
1920:1014-1055
1903:PSI Domain
1898:1698-1719
1848:CUB Domain
1732:CUB domain
1411:Zebra fish
1301:King Cobra
1191:Orca Whale
355:(ortholog)
92:HomoloGene
3778:Maglott D
3416:CiteSeerX
3278:(4): 181.
3006:Kelley LA
2365:pathways.
2175:2611-2785
2161:2588-2610
2133:2588-2610
2108:NetNGlyc
2066:SUMOplot
1782:integrins
1593:Promoters
1546:XP_789561
1165:Bos Mutus
959:NP_001401
908:NM_001410
900:NM_178121
730:Orthologs
100:GeneCards
4216:19218456
4162:23063620
4118:24713578
4055:Genomics
4046:24052814
3993:24458945
3871:23063620
3816:21115458
3764:18940858
3715:22121220
3665:22139911
3616:19919682
3562:21097893
3511:15 April
3487:17483518
3438:15223320
3393:18810164
3385:15174133
3311:10600390
3261:16844986
3212:18000004
3163:10087920
3101:21109532
3049:27 April
3044:19247286
2990:24 April
2967:27 April
2833:19218456
2736:–
2715:–
2675:in males
2463:SMARCD3
2330:Function
2309:Location
2150:Phobius
2122:SignalP
2080:NetPhos
2015:Feature
1765:Laminin
1746:Calcium
1602:Archived
1584:Paralogs
1524:EFX84934
1502:JAB95791
1436:AHI50432
1304:ETE71721
1028:Wikidata
709:Sources:
579:membrane
4207:2651267
4184:Bibcode
4153:3487118
4109:4122622
4075:9693030
4037:3776557
4001:3040251
3954:3322002
3862:3487118
3807:3013746
3755:2686466
3706:3245075
3656:3245017
3607:3091323
3553:3013736
3478:1933244
3346:7583634
3252:1538823
3203:2238974
3128:2288911
3092:3013737
2940:8 March
2935:"BLAST"
2921:9600884
2889:Bibcode
2824:2651267
2801:Bibcode
2738:Ensembl
2717:Ensembl
2486:STRING
2475:SMARCD3
2433:CACNA1A
2147:1- 2587
1854:40-147
1774:plexins
842:UniProt
797:Ensembl
736:Species
715:QuickGO
589:nucleus
443:utricle
330:pattern
188:19q13.2
88:2446294
56:Aliases
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4204:
4160:
4150:
4116:
4106:
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3991:
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2632:Visit
2454:death.
2445:Cav2.1
2337:Source
2036:Source
1789:cells.
1786:Plexin
1717:PHYRE2
1610:megf8.
1014:search
1012:PubMed
875:P60882
856:Q7Z7M0
785:269878
752:Entrez
501:BioGPS
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4014:eLife
3997:S2CID
3389:S2CID
2912:34487
2515:Y3542
2492:FIHB1
2415:ATXN7
2403:ATXN7
2356:GFI1B
2345:GFI1B
2136:SAPS
2094:SAPS
1843:1-34
1623:megf8
1577:2534
1533:2888
1511:2959
1489:2913
1467:2952
1445:2875
1423:2870
1401:2813
1379:2730
1357:2465
1335:2793
1291:2789
1279:Mouse
1269:2789
1247:2068
1225:2708
1203:2789
1181:2842
1159:2778
1069:BLAST
1056:Megf8
745:Mouse
740:Human
711:Amigo
353:Mouse
346:Human
293:Start
228:Mouse
192:Start
125:Human
104:MEGF8
96:15988
63:MEGF8
35:MEGF8
18:MEGF8
4212:PMID
4158:PMID
4114:PMID
4071:PMID
4042:PMID
3989:PMID
3977:164A
3950:PMID
3907:PMID
3867:PMID
3812:PMID
3760:PMID
3711:PMID
3661:PMID
3612:PMID
3558:PMID
3513:2014
3483:PMID
3434:PMID
3381:PMID
3342:PMID
3307:PMID
3257:PMID
3208:PMID
3159:PMID
3124:PMID
3097:PMID
3051:2014
3040:PMID
2992:2014
2969:2014
2961:SAPS
2942:2014
2917:PMID
2859:2014
2829:PMID
2619:SNPs
2539:ProW
2386:ATN1
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2191:NCBI
1990:SCOP
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766:1954
336:Bgee
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245:Chr.
183:Band
142:Chr.
76:OMIM
4202:PMC
4192:doi
4180:106
4148:PMC
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4096:doi
4063:doi
4032:PMC
4022:doi
3981:doi
3942:doi
3899:doi
3857:PMC
3849:doi
3802:PMC
3794:doi
3750:PMC
3742:doi
3701:PMC
3693:doi
3651:PMC
3643:doi
3602:PMC
3592:doi
3548:PMC
3540:doi
3473:PMC
3465:doi
3426:doi
3412:340
3373:doi
3334:doi
3299:doi
3295:294
3247:PMC
3239:doi
3198:PMC
3190:doi
3151:doi
3087:PMC
3079:doi
3030:hdl
3022:doi
2907:PMC
2897:doi
2819:PMC
2809:doi
2797:106
2074:116
1574:51%
1571:38%
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1530:48%
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