292:
269:
42:
570:
In a small study of 14 subjects, MK-677 dosed at 25mg/day at bedtime was shown to increase REM sleep by 20% and 50% in young and older subjects respectively. Treatment with MK-677 also resulted in an approximate 50% increase in deep sleep in young subjects.
878:
Holst B, Frimurer TM, Mokrosinski J, Halkjaer T, Cullberg KB, Underwood CR, Schwartz TW (January 2009). "Overlapping binding site for the endogenous agonist, small-molecule agonists, and ago-allosteric modulators on the ghrelin receptor".
1041:
Thorner MO, Chapman IM, Gaylinn BD, Pezzoli SS, Hartman ML (1997). "Growth hormone-releasing hormone and growth hormone-releasing peptide as therapeutic agents to enhance growth hormone secretion in disease and aging".
599:, it has not yet been approved to be marketed for consumption by humans in the United States. However, it has been used experimentally by some in the bodybuilding community. The use of MK-677 is banned in most sports.
1276:
Copinschi G, Leproult R, Van
Onderbergen A, Caufriez A, Cole KY, Schilling LM, et al. (October 1997). "Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man".
839:"Identification, characterization, and biological activity of specific receptors for natural (ghrelin) and synthetic growth hormone secretagogues and analogs in human breast carcinomas and cell lines"
1465:
364:
1153:"Effect of alendronate and MK-677 (a growth hormone secretagogue), individually and in combination, on markers of bone turnover and bone mineral density in postmenopausal osteoporotic women"
1399:
406:
InChI=1S/C27H36N4O5S/c1-26(2,28)25(33)29-22(18-36-17-20-9-5-4-6-10-20)24(32)30-15-13-27(14-16-30)19-31(37(3,34)35)23-12-8-7-11-21(23)27/h4-12,22H,13-19,28H2,1-3H3,(H,29,33)/t22-/m1/s1
973:
Chapman IM (1996). "Stimulation of the growth hormone (gh)-insulin-like growth factor I axis by Daily Oral
Administration of a GH secretogogue (MK-677) in healthy elderly subjects".
1112:"Oral administration of the growth hormone secretagogue MK-677 increases markers of bone turnover in healthy and functionally impaired elderly adults. The MK-677 Study Group"
583:, MK-677 performed better than other growth hormone secretagogues at improving growth hormone levels. An ongoing study compares MK-677 directly to injectable hGH in terms of
1458:
1192:
Smith RG, Sun Y, Jiang H, Albarran-Zeckler R, Timchenko N (November 2007). "Ghrelin receptor (GHS-R1A) agonists show potential as interventive agents during aging".
1071:"Oral administration of growth hormone (GH) releasing peptide-mimetic MK-677 stimulates the GH/insulin-like growth factor-I axis in selected GH-deficient adults"
1002:"Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects"
1474:
378:
1451:
2112:
1314:"A GH Secretagogue Receptor Agonist (LUM-201) Elicits Greater GH Responses than Standard GH Secretagogues in Subjects of a Pediatric GH Deficiency Trial"
1814:
1391:
2154:
644:
1251:
1894:
608:
485:
2149:
542:. It is under investigation as a potential treatment for reduced levels of these hormones, such as in children or elderly adults with
1369:
437:
398:
1849:
136:
81:
716:
2139:
1637:
924:"Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial"
2134:
511:
228:
120:
2144:
489:
248:
527:
1429:
580:
543:
2164:
1547:
1537:
596:
89:
739:"Design and biological activities of L-163,191 (MK-0677): a potent, orally active growth hormone secretagogue"
1495:
559:
62:
1362:"Phase 2 Study of LUM-201 in Children With Growth Hormone Deficiency (OraGrowtH210 Trial) - Full Text View"
287:
1527:
466:
1754:
2169:
1652:
1794:
1572:
2097:
2073:
1522:
1201:
750:
584:
551:
107:
1919:
1679:
1512:
660:
Smith RG, Van der Ploeg LH, Howard AD, Feighner SD, Cheng K, Hickey GJ, et al. (October 1997).
264:
2068:
1854:
1734:
1517:
1244:"An Anti-frailty Pill For Seniors? New Drug Increases Muscle Mass In Arms And Legs Of Older Adults"
535:
514:(IGF-1) and produces sustained increases in the plasma levels of these hormones while also raising
474:
470:
157:
69:
1914:
1779:
922:
Nass R, Pezzoli SS, Oliveri MC, Patrie JT, Harrell FE Jr, Clasey JL, et al. (November 2008).
2159:
1804:
1714:
1694:
1627:
1592:
1582:
1552:
1487:
1243:
1225:
904:
1974:
1859:
1799:
1684:
1602:
1597:
1562:
2053:
2048:
2031:
2021:
1979:
1844:
1834:
1789:
1744:
1704:
1699:
1669:
1612:
2063:
1924:
1884:
1542:
1343:
1294:
1217:
1174:
1133:
1092:
1069:
Chapman IM, Pescovitz OH, Murphy G, Treep T, Cerchio KA, Krupa D, et al. (October 1997).
1051:
1023:
1000:
Chapman IM, Bach MA, Van Cauter E, Farmer M, Krupa D, Taylor AM, et al. (December 1996).
982:
955:
896:
860:
819:
778:
683:
640:
2087:
2082:
1764:
1759:
737:
Patchett AA, Nargund RP, Tata JR, Chen MH, Barakat KJ, Johnston DB, et al. (July 1995).
634:
1954:
1949:
1944:
1939:
1769:
1739:
1674:
1333:
1325:
1286:
1209:
1164:
1123:
1082:
1013:
945:
940:
935:
888:
850:
809:
768:
758:
673:
304:
217:
166:
99:
1151:
Murphy MG, Weiss S, McClung M, Schnitzer T, Cerchio K, Connor J, et al. (March 2001).
237:
1361:
837:
Cassoni P, Papotti M, Ghè C, Catapano F, Sapino A, Graziani A, et al. (April 2001).
291:
268:
1205:
754:
1532:
1484:
1338:
1313:
950:
923:
531:
493:
478:
2128:
1443:
773:
738:
280:
1110:
Murphy MG, Bach MA, Plotkin D, Bolognese J, Ng J, Krupa D, et al. (July 1999).
798:"Identification of a new G-protein-linked receptor for growth hormone secretagogues"
197:
2016:
1749:
1567:
1229:
908:
539:
41:
1424:
708:
2036:
1994:
1989:
1984:
1969:
1874:
1869:
1729:
1689:
1617:
1557:
1128:
1111:
1018:
1001:
796:
Pong SS, Chaung LY, Dean DC, Nargund RP, Patchett AA, Smith RG (January 1996).
743:
Proceedings of the
National Academy of Sciences of the United States of America
2011:
1999:
1964:
1929:
1864:
1774:
1724:
1719:
1709:
1587:
814:
797:
555:
497:
340:
208:
2041:
2006:
1434:
1213:
1087:
1070:
763:
507:
1347:
1221:
1178:
1169:
1152:
1137:
959:
900:
892:
864:
855:
838:
678:
661:
123:
levels remain elevated in humans with a single oral dose for up to 24 hours
33:
1298:
1096:
1055:
1027:
986:
823:
782:
687:
1839:
1577:
515:
172:
1934:
613:
503:
500:
481:
183:
1329:
1290:
17:
1959:
547:
116:
530:, increasing growth hormone secretion by up to 97%, and to increase
386:
O=S(C)(=O)N(C2)c1ccccc1C23CCN(CC3)C(=O)C(NC(=O)C(N)(C)C)COCc4ccccc4
363:
354:
1447:
554:, making it a promising potential therapy for the treatment of
1392:"Ibutamoren (MK 677) not OK - Don't be fooled by marketing!"
253:
1653:
438:
1815:
662:"Peptidomimetic regulation of growth hormone secretion"
639:. Springer Science & Business Media. pp. 45–.
526:
Ibutamoren has been shown to sustain activation of the
423:
1638:
1430:
MK-677 and A Potential
Dementia Link - Loungecity.org
562:
stage of development for growth hormone deficiency.
148:--1'-yl)-1-oxo-3-phenylmethoxypropan-2-yl]propanamide
2098:
1479:
1157:
The
Journal of Clinical Endocrinology and Metabolism
1075:
The
Journal of Clinical Endocrinology and Metabolism
1006:
The
Journal of Clinical Endocrinology and Metabolism
843:
The
Journal of Clinical Endocrinology and Metabolism
636:
Human Growth
Hormone: Research and Clinical Practice
2096:
1895:
1893:
1813:
1651:
1494:
546:, and human studies have shown it to increase both
352:
339:
303:
298:
279:
247:
227:
207:
182:
156:
127:
106:
98:
80:
75:
61:
53:
48:
975:Journal of Clinical Endocrinology & Metabolism
1548:Placental growth hormone (growth hormone variant)
196:
165:
1459:
703:
701:
699:
697:
8:
32:
1466:
1452:
1444:
1194:Annals of the New York Academy of Sciences
290:
267:
216:
1337:
1168:
1127:
1086:
1017:
949:
939:
854:
813:
772:
762:
677:
443:Tooltip International Nonproprietary Name
236:
633:Smith RG, Thorner MO (28 January 2000).
558:. As of June 2017, ibutamoren is in the
1312:Bright GM, Thorner MO (30 March 2022).
941:10.7326/0003-4819-149-9-200811040-00003
625:
403:
383:
263:
141:
1643:Tooltip Growth hormone-binding protein
1496:
1475:
281:
31:
1372:from the original on 4 September 2023
1271:
1269:
672:(5). The Endocrine Society: 621–645.
510:of several hormones including GH and
7:
1254:from the original on 7 November 2017
1116:Journal of Bone and Mineral Research
609:List of growth hormone secretagogues
506:. It has been shown to increase the
57:MK-677; MK-0677; L-163,191; Oratrope
1044:Recent Progress in Hormone Research
187:
25:
1402:from the original on 9 April 2024
709:"Ibutamoren - Lumos Pharma/Merck"
321:
315:
40:
1318:Hormone Research in Paediatrics
719:from the original on 2018-09-27
496:(GH)-stimulating action of the
411:Key:UMUPQWIGCOZEOY-JOCHJYFZSA-N
1588:Somatrogon (MOD-4023; hGH-CTP)
461:; former tentative brand name
333:
327:
309:
1:
2155:Growth hormone secretagogues
1050:: 215–44, discussion 244–6.
579:In a study of children with
566:Effect on sleep architecture
512:insulin-like growth factor 1
445:) (developmental code names
1625:Antisense oligonucleotides:
1129:10.1359/jbmr.1999.14.7.1182
928:Annals of Internal Medicine
490:growth hormone secretagogue
2186:
1435:Ghrelin Over-Stimulation,
1019:10.1210/jcem.81.12.8954023
299:Chemical and physical data
2150:Ghrelin receptor agonists
1396:Sport Integrity Australia
815:10.1210/mend.10.1.8838145
595:Since MK-677 is still an
581:growth hormone deficiency
575:Growth hormone deficiency
544:growth hormone deficiency
419:
394:
374:
132:
39:
1538:Human placental lactogen
1425:Ibutamoren - AdisInsight
597:Investigational New Drug
90:Investigational New Drug
1214:10.1196/annals.1404.023
1088:10.1210/jcem.82.10.4297
802:Molecular Endocrinology
764:10.1073/pnas.92.15.7001
1930:Examorelin (hexarelin)
1170:10.1210/jcem.86.3.7294
893:10.1124/mol.108.049189
881:Molecular Pharmacology
856:10.1210/jcem.86.4.7402
679:10.1210/edrv.18.5.0316
556:frailty in the elderly
2140:Anti-aging substances
1985:Pralmorelin (GHRP-2)
1528:Eftansomatropin alfa
1437:Molecular Psychiatry
587:in this population.
552:bone mineral density
2135:4-Phenylpiperidines
2027:Ibutamoren (MK-677)
1855:Modified GRF (1-29)
1755:Somatostatin (1-28)
1750:Somatostatin (GHIH)
1518:Bovine somatotropin
1250:. 5 November 2008.
1206:2007NYASA1119..147S
755:1995PNAS...92.7001P
522:Effect on lean mass
36:
2145:Experimental drugs
1439:Study - Nature.org
1394:. Integrity Blog.
1366:clinicaltrials.gov
1279:Neuroendocrinology
534:with no change in
2122:
2121:
2104:
2077:
1901:
1821:
1795:Cyclosomatostatin
1659:
1635:Binding proteins:
1543:Lonapegsomatropin
1502:
1330:10.1159/000524244
1291:10.1159/000127249
1081:(10): 3455–3463.
1012:(12): 4249–4257.
981:(12): 4249–4257.
749:(15): 7001–7005.
666:Endocrine Reviews
646:978-1-59259-015-5
431:
430:
365:Interactive image
249:CompTox Dashboard
144:2-amino-2-methyl-
27:Experimental drug
16:(Redirected from
2177:
2102:
2100:
2075:
1899:
1897:
1819:
1817:
1657:
1655:
1644:
1640:
1573:Somatropin pegol
1500:
1498:
1481:
1477:
1468:
1461:
1454:
1445:
1412:
1411:
1409:
1407:
1388:
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1341:
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1303:
1302:
1273:
1264:
1263:
1261:
1259:
1240:
1234:
1233:
1189:
1183:
1182:
1172:
1163:(3): 1116–1125.
1148:
1142:
1141:
1131:
1122:(7): 1182–1188.
1107:
1101:
1100:
1090:
1066:
1060:
1059:
1038:
1032:
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1021:
997:
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964:
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953:
943:
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913:
912:
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858:
849:(4): 1738–1745.
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766:
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728:
727:
725:
724:
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691:
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591:Non-research use
492:, mimicking the
486:ghrelin receptor
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2165:Spiro compounds
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2118:
2101:
2092:
1898:
1889:
1818:
1809:
1656:
1647:
1642:
1523:Efpegsomatropin
1499:
1490:
1472:
1421:
1416:
1415:
1405:
1403:
1398:. 23 May 2022.
1390:
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585:height velocity
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469:, long-acting,
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109:
100:Pharmacokinetic
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64:
28:
23:
22:
15:
12:
11:
5:
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2167:
2162:
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1982:
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1967:
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1957:
1952:
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1932:
1927:
1922:
1920:Cortistatin-14
1917:
1905:
1903:
1891:
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1887:
1878:
1877:
1872:
1867:
1862:
1857:
1852:
1847:
1842:
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1823:
1820:(somatocrinin)
1811:
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1732:
1727:
1722:
1717:
1712:
1707:
1702:
1697:
1692:
1687:
1682:
1680:Cortistatin-14
1677:
1672:
1663:
1661:
1658:(somatostatin)
1649:
1648:
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1621:
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1535:
1533:Growth hormone
1530:
1525:
1520:
1515:
1513:Albusomatropin
1506:
1504:
1501:(somatotropin)
1492:
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1471:
1470:
1463:
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1448:
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1427:
1420:
1419:External links
1417:
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1285:(4): 278–286.
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1200:(1): 147–164.
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1143:
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992:
965:
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532:lean body mass
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2078:-Lys³)-GHRP-6
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2069:Cortistatin-8
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1735:Pentetreotide
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528:GH–IGF-1 axis
521:
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471:orally-active
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282:ECHA InfoCard
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171:159752-10-0 (
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74:
71:
68:
66:
60:
56:
52:
49:Clinical data
47:
43:
38:
30:
19:
2170:Orphan drugs
2061:Antagonists:
2060:
2045:
2026:
2017:Capromorelin
2004:Non-peptide:
2003:
1915:Alexamorelin
1911:
1908:
1882:Antagonists:
1881:
1831:
1828:
1787:Antagonists:
1786:
1780:Veldoreotide
1666:
1634:
1624:
1610:Antagonists:
1609:
1568:Somatotropin
1509:
1436:
1404:. Retrieved
1395:
1386:
1374:. Retrieved
1365:
1356:
1324:(1): 76–81.
1321:
1317:
1307:
1282:
1278:
1256:. Retrieved
1248:ScienceDaily
1247:
1238:
1197:
1193:
1187:
1160:
1156:
1146:
1119:
1115:
1105:
1078:
1074:
1064:
1047:
1043:
1036:
1009:
1005:
995:
978:
974:
968:
931:
927:
917:
887:(1): 44–59.
884:
880:
873:
846:
842:
832:
808:(1): 57–61.
805:
801:
791:
746:
742:
732:
721:. Retrieved
712:
669:
665:
655:
635:
628:
594:
578:
569:
540:visceral fat
525:
462:
458:
454:
450:
446:
433:
432:
421:
145:
108:Elimination
82:Legal status
76:Legal status
29:
2037:Macimorelin
1995:Tabimorelin
1990:Relamorelin
1970:Lenomorelin
1875:Tesamorelin
1870:Somatorelin
1805:Satoreotide
1730:Pasireotide
1715:NNC 26-9100
1695:Ilatreotide
1690:Edotreotide
1628:Atesidorsen
1618:Pegvisomant
1593:Somavaratan
1583:Sometribove
1558:Somapacitan
1553:Somagrebove
1376:4 September
1258:28 February
713:AdisInsight
560:preclinical
548:muscle mass
479:non-peptide
348: g·mol
288:100.236.734
167:159634-47-6
128:Identifiers
54:Other names
2129:Categories
2012:Anamorelin
2000:Ulimorelin
1975:Livoletide
1965:Ipamorelin
1865:Sermorelin
1860:Rismorelin
1800:CYN-154806
1775:Vapreotide
1725:Octreotide
1720:Octreotate
1710:Lanreotide
1685:Depreotide
1603:Somidobove
1598:Somavubove
1563:Somatosalm
1488:modulators
723:2017-12-14
620:References
498:endogenous
434:Ibutamoren
353:3D model (
341:Molar mass
238:GJ0EGN38UL
209:ChemSpider
158:CAS Number
137:IUPAC name
34:Ibutamoren
2160:Indolines
2054:LY-444711
2049:LY-426410
2046:Unsorted:
2042:SM-130686
2032:L-692,585
2022:CP-464709
2007:Adenosine
1980:LY-444711
1909:Agonists:
1900:(ghrelin)
1845:Dumorelin
1835:ALRN-5281
1829:Agonists:
1790:BIM-23056
1745:Seglitide
1705:L-817,818
1700:L-803,087
1670:BIM-23052
1667:Agonists:
1613:G120K-hGH
1510:Agonists:
1485:signaling
508:secretion
475:selective
459:L-163,191
110:half-life
63:Routes of
2115:instead.
2064:A-778193
1925:EP-51216
1912:Peptide:
1885:MZ-5-156
1840:CJC-1295
1832:Peptide:
1578:Somatrem
1400:Archived
1370:Archived
1348:35354138
1252:Archived
1222:18056963
1179:11238495
1138:10404019
960:18981485
901:18923064
865:11297611
717:Archived
603:See also
518:levels.
516:cortisol
463:Oratrope
424:(verify)
173:mesylate
70:By mouth
2088:YIL-781
2083:JMV2959
1935:Ghrelin
1765:SRIF-28
1760:SRIF-14
1406:9 April
1339:9227666
1299:9349662
1230:3220799
1202:Bibcode
1097:9329386
1056:9238854
1028:8954023
987:8954023
951:2757071
909:2218638
824:8838145
783:7624358
751:Bibcode
688:9331545
614:Ghrelin
504:ghrelin
501:hormone
484:of the
482:agonist
465:) is a
455:LUM-201
451:MK-0677
305:Formula
198:9939050
184:PubChem
117:beagles
1960:GHRP-6
1955:GHRP-5
1950:GHRP-4
1945:GHRP-3
1940:GHRP-1
1770:TT-232
1740:RC-160
1675:CH-275
1346:
1336:
1297:
1228:
1220:
1177:
1136:
1095:
1054:
1026:
985:
958:
948:
907:
899:
863:
822:
781:
771:
686:
643:
488:and a
477:, and
467:potent
447:MK-677
379:SMILES
346:528.67
218:154975
18:MK-677
2099:IGF-1
1480:IGF-1
1226:S2CID
905:S2CID
774:41459
399:InChI
355:JSmol
121:IGF-1
2113:here
2111:See
1850:GHRH
1816:GHRH
1654:GHIH
1639:GHBP
1482:axis
1408:2024
1378:2023
1344:PMID
1295:PMID
1260:2018
1218:PMID
1198:1119
1175:PMID
1134:PMID
1093:PMID
1052:PMID
1024:PMID
983:PMID
956:PMID
897:PMID
861:PMID
820:PMID
779:PMID
684:PMID
641:ISBN
550:and
229:UNII
102:data
1896:GHS
1334:PMC
1326:doi
1287:doi
1210:doi
1165:doi
1124:doi
1083:doi
1014:doi
946:PMC
936:doi
932:149
889:doi
851:doi
810:doi
769:PMC
759:doi
674:doi
538:or
439:INN
254:EPA
188:CID
119:);
2131::
2044:;
2002:;
1497:GH
1476:GH
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930:.
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885:75
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806:10
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777:.
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670:18
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436:(
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334:S
331:5
328:O
325:4
322:N
316:H
310:C
256:)
252:(
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146:N
20:)
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