1565:, or a fluorogenic activity probe., replaces the propeptide in the enzyme active site where it is cleaved. The catalytic domain contains two zinc and three calcium atoms. The catalytic zinc is coordinated by three histidines from the conserved HEXXHXXGXXH binding motif. The other zinc atom and the three calcium atoms are structural. A conserved methionine, which forms a unique “Met-turn” structure categorizes MMP9 as a metzincin. Three type II fibronectin repeats are inserted in the catalytic domain, although these domains are omitted in most crystallographic structures of MMP9 in complex with inhibitors. The active form of MMP9 also contains a C-terminal hemopexin-like domain. This domain is ellipsoidal in shape, formed by four
378:
355:
252:
277:
3615:
384:
283:
3600:
1606:
angiogenesis, to stromal remodeling, and ultimately metastasis. However, because of its physiologic function, it may be difficult to leverage
Gelatinase B inhibition into cancer therapy modalities. However, Gelatinase B has been investigated in tumor metastasis diagnosis- Complexes of Gelatinase B/Tissue Inhibitors of Metalloproteinases are seen to be increased in gastrointestinal cancer and gynecologic malignancies
29:
4331:
1546:
1493:
1605:
One of MMP9's most widely associated pathologies is the relationship to cancer, due to its role in extracellular matrix remodeling and angiogenesis. For example, its increased expression was seen in a metastatic mammary cancer cell line. Gelatinase B plays a central role in tumor progression, from
1483:
healing. Using a MMP9 deficient mouse model, it was seen that MMP9 coordinated epithelial wound repair and deficient mice were unable to remove the fibrinogen matrix during wound healing. When interacting with TGF-Ăź1, Gelatinase B also stimulates collagen contraction, aiding in wound closure.
1471:. Knock-out models of MMP9 result in delayed apoptosis, vascularization, and ossification of hypertrophic chondrocytes. Lastly, there is significant evidence that Gelatinase B is required for the recruitment of endothelial stem cells, a critical component of angiogenesis
55:
629:
2468:
Bode W, Gomis-Rüth FX, Stöckler W (September 1993). "Astacins, serralysins, snake venom and matrix metalloproteinases exhibit identical zinc-binding environments (HEXXHXXGXXH and Met-turn) and topologies and should be grouped into a common family, the 'metzincins'".
1609:
MMPs such as MMP9 can be involved in the development of several human malignancies, as degradation of collagen IV in basement membrane and extracellular matrix facilitates tumor progression, including invasion, metastasis, growth and angiogenesis.
1637:
A study on
Ghanaian population showed that MMP-9 single nucleotide polymorphism 1562 C > T (rs3918242) was protective against placental malaria which suggests a possible role of MMP-9 in susceptibility to malaria.
2548:
Gruber BL, Sorbi D, French DL, Marchese MJ, Nuovo GJ, Kew RR, Arbeit LA (February 1996). "Markedly elevated serum MMP-9 (gelatinase B) levels in rheumatoid arthritis: a potentially useful laboratory marker".
2512:
Gomis-RĂĽth FX, Gohlke U, Betz M, Knäuper V, Murphy G, LĂłpez-OtĂn C, Bode W (December 1996). "The helping hand of collagenase-3 (MMP-13): 2.7 A crystal structure of its C-terminal haemopexin-like domain".
1935:
Hirose Y, Chiba K, Karasugi T, Nakajima M, Kawaguchi Y, Mikami Y, Furuichi T, Mio F, Miyake A, Miyamoto T, Ozaki K, Takahashi A, Mizuta H, Kubo T, Kimura T, Tanaka T, Toyama Y, Ikegawa S (May 2008).
2256:
Buisson AC, Zahm JM, Polette M, Pierrot D, Bellon G, Puchelle E, Birembaut P, Tournier JM (February 1996). "Gelatinase B is involved in the in vitro wound repair of human respiratory epithelium".
3254:
St-Pierre Y, Van
Themsche C, Estève PO (September 2003). "Emerging features in the regulation of MMP-9 gene expression for the development of novel molecular targets and therapeutic strategies".
2719:
Zucker S, Lysik RM, DiMassimo BI, Zarrabi HM, Moll UM, Grimson R, Tickle SP, Docherty AJ (August 1995). "Plasma assay of gelatinase B: tissue inhibitor of metalloproteinase complexes in cancer".
2936:"Clinical trial of doxycycline for matrix metalloproteinase-9 inhibition in patients with an abdominal aneurysm: doxycycline selectively depletes aortic wall neutrophils and cytotoxic T cells"
1577:
arranged around a funnel-like tunnel that contains two calcium and two chloride ions. The hemopexin domain is important to facilitate the cleavage of triple helical interstitial collagens. .
1984:
Delclaux C, Delacourt C, D'Ortho MP, Boyer V, Lafuma C, Harf A (March 1996). "Role of gelatinase B and elastase in human polymorphonuclear neutrophil migration across basement membrane".
1892:
Van den Steen PE, Dubois B, Nelissen I, Rudd PM, Dwek RA, Opdenakker G (December 2002). "Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9)".
2584:
Clark AW, Krekoski CA, Bou SS, Chapman KR, Edwards DR (November 1997). "Increased gelatinase A (MMP-2) and gelatinase B (MMP-9) activities in human brain after focal ischemia".
2111:"Gelatinase-A (MMP-2), gelatinase-B (MMP-9) and membrane type matrix metalloproteinase-1 (MT1-MMP) are involved in different aspects of the pathophysiology of malignant gliomas"
2299:
Mohan R, Chintala SK, Jung JC, Villar WV, McCabe F, Russo LA, Lee Y, McCarthy BE, Wollenberg KR, Jester JV, Wang M, Welgus HG, Shipley JM, Senior RM, Fini ME (January 2002).
391:
290:
3145:
Starckx S, Van den Steen PE, Wuyts A, Van Damme J, Opdenakker G (February 2002). "Neutrophil gelatinase B and chemokines in leukocytosis and stem cell mobilization".
2392:
Tranchant I, Vera L, Czarny B, Amoura M, Cassar E, Beau F, Stura EA, Dive V (March 2014). "Halogen bonding controls selectivity of FRET substrate probes for MMP-9".
3655:
3614:
3334:
Lee JM, Yin K, Hsin I, Chen S, Fryer JD, Holtzman DM, Hsu CY, Xu J (March 2005). "Matrix metalloproteinase-9 in cerebral-amyloid-angiopathy-related hemorrhage".
1849:
Vandooren J, Van den Steen PE, Opdenakker G (2013). "Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): the next decade".
1459:
MMP9 may play an important role in angiogenesis and neovascularization. For example, MMP9 appears to be involved in the remodeling associated with malignant
1585:
MMP9 has been found to be associated with numerous pathological processes, including cancer, placental malaria, immunologic and cardiovascular diseases.
1531:. The propeptide domain is characterized by a conserved PRCGVPD sequence. The Cys within this sequence is known as the “cysteine switch”. It ligates the
1017:
998:
213:
1625:
MMP9 has been found to be associated with the development of aortic aneurysms, and its disruption prevents the development of aortic aneurysms.
1496:
ProMMP9 (pro-peptide (red), catalytic domain (green) with fibronectin domains (cyan), with detail of the "cysteine switch" (from PDB entry 1L6J)
4351:
3997:
3579:
1729:
2340:
Kobayashi T, Kim H, Liu X, Sugiura H, Kohyama T, Fang Q, Wen FQ, Abe S, Wang X, Atkinson JJ, Shipley JM, Senior RM, Rennard SI (June 2014).
1711:
2887:"Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms"
2109:
Forsyth PA, Wong H, Laing TD, Rewcastle NB, Morris DG, Muzik H, Leco KJ, Johnston RN, Brasher PM, Sutherland G, Edwards DR (April 1999).
3684:
3648:
2732:
2269:
1750:
377:
4356:
3599:
2207:
Heissig B, Hattori K, Dias S, Friedrich M, Ferris B, Hackett NR, Crystal RG, Besmer P, Lyden D, Moore MA, Werb Z, Rafii S (May 2002).
1224:
1217:
4050:
354:
1629:
suppresses the growth of aortic aneurysms in animal models through its inhibition of MMP9 reduces aortic inflammation in humans.
2086:
2069:
1937:"A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation"
2629:"The alpha 3 beta 1 integrin is associated with mammary carcinoma cell metastasis, invasion, and gelatinase B (MMP-9) activity"
1698:
1677:
1416:, intervertebral disc proteins, regulate interaction with matrix metalloproteinases (MMPs) 2 and 9, which are key effectors of
2429:"Activation of matrix metalloproteinase-9 (MMP-9) via a converging plasmin/stromelysin-1 cascade enhances tumor cell invasion"
3641:
2645:
2628:
276:
251:
4206:
1694:
52:
4321:
1673:
1561:
cleaves the propeptide from the 92-kDa pro-MMP-9, yielding an 82-kDa enzymatically active enzyme. In the active enzyme a
4002:
2977:"Matrix metalloproteinase-9 polymorphism 1562 C > T (rs3918242) associated with protection against placental malaria"
193:
1439:
MMP9 plays several important functions within neutrophil action, such as degrading extracellular matrix, activation of
3184:"Time course of upregulation of inflammatory mediators in the hemorrhagic brain in rats: correlation with brain edema"
3367:
Nair RR, Boyd DD (November 2005). "Expression cloning of novel regulators of 92 kDa type IV collagenase expression".
2627:
Morini M, Mottolese M, Ferrari N, Ghiorzo F, Buglioni S, Mortarini R, Noonan DM, Natali PG, Albini A (August 2000).
1447:. In a mouse model, MMP9 deficiency resulted in resistance to endotoxin shock, suggesting that MMP9 is important in
390:
289:
184:, CLG4B, GELB, MANDP2, MMP-9, 92 kDa type IV collagenase, 92 kDa gelatinase, gelatinase B, matrix metallopeptidase 9
3896:
3891:
2764:"The role of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in the development of esophageal cancer"
2209:"Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand"
1327:
4191:
2885:
Pyo R, Lee JK, Shipley JM, Curci JA, Mao D, Ziporin SJ, Ennis TL, Shapiro SD, Senior RM, Thompson RW (June 2000).
2019:
Opdenakker G, Van den Steen PE, Dubois B, Nelissen I, Van
Coillie E, Masure S, Proost P, Van Damme J (June 2001).
4307:
4294:
4281:
4268:
4255:
4242:
4229:
3675:
3572:
2846:"Identification of matrix metalloproteinases 3 (stromelysin-1) and 9 (gelatinase B) in abdominal aortic aneurysm"
383:
282:
4201:
3026:"Matrix Metalloproteinase 9 Testing in Dry Eye Disease Using a Commercially Available Point-of-Care Immunoassay"
4155:
4098:
4012:
3829:
3672:
2160:"MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes"
1562:
1524:
1383:
1343:
1331:
1062:
201:
4103:
1410:
progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling.
1043:
1402:
and other extracellular matrix proteins. Studies in rhesus monkeys suggest that the enzyme is involved in
3025:
1810:"Neuroprotection by inhibition of matrix metalloproteinases in a mouse model of intracerebral haemorrhage"
3398:"Dynamic changes of inflammatory markers in brain after hemorrhagic stroke in humans: a postmortem study"
4124:
4043:
3987:
3441:"Cerebroprotection by the neuronal PGE2 receptor EP2 after intracerebral hemorrhage in middle-aged mice"
2158:
Vu TH, Shipley JM, Bergers G, Berger JE, Helms JA, Hanahan D, Shapiro SD, Senior RM, Werb Z (May 1998).
1351:
265:
4196:
3225:
Bischof P, Meisser A, Campana A (2002). "Control of MMP-9 expression at the maternal-fetal interface".
3102:
Zhao X, Wu T, Chang CF, Wu H, Han X, Li Q, Gao Y, Li Q, Hou Z, Maruyama T, Zhang J, Wang J (May 2015).
1549:
MMP-9 catalytic domain in complex with a fluorogenic synthetic peptidic substrate. From PDB entry 4JIJ.
3668:
3565:
1594:
1417:
1347:
1304:
3291:
Wu H, Wu T, Hua W, Dong X, Gao Y, Zhao X, Chen W, Cao W, Yang Q, Qi J, Zhou J, Wang J (March 2015).
180:
4160:
3024:
Messmer, Elisabeth M.; von
Lindenfels, Victoria; Garbe, Alexandra; Kampik, Anselm (November 2016).
2342:"Matrix metalloproteinase-9 activates TGF-β and stimulates fibroblast contraction of collagen gels"
1619:
803:
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
4361:
4093:
3507:
3355:
3279:
3170:
2744:
2609:
2494:
2281:
2050:
1917:
1874:
1300:
225:
3482:
Ram M, Sherer Y, Shoenfeld Y (July 2006). "Matrix metalloproteinase-9 and autoimmune diseases".
1200:
1179:
1153:
1132:
3633:
2301:"Matrix metalloproteinase gelatinase B (MMP-9) coordinates and effects epithelial regeneration"
3537:
3499:
3470:
3427:
3384:
3347:
3322:
3271:
3242:
3213:
3162:
3133:
3090:
3045:
3006:
2957:
2916:
2867:
2826:
2785:
2736:
2701:
2650:
2601:
2566:
2530:
2486:
2450:
2409:
2371:
2322:
2273:
2238:
2189:
2140:
2091:
2042:
2001:
1966:
1909:
1866:
1831:
1790:
1528:
1433:
173:
45:
4139:
4134:
4108:
4036:
3936:
3491:
3460:
3452:
3417:
3409:
3376:
3339:
3312:
3304:
3263:
3234:
3203:
3195:
3154:
3123:
3115:
3080:
3037:
2996:
2988:
2947:
2906:
2898:
2857:
2816:
2775:
2728:
2691:
2681:
2640:
2593:
2558:
2522:
2478:
2440:
2401:
2361:
2353:
2312:
2265:
2228:
2220:
2179:
2171:
2130:
2122:
2081:
2032:
1993:
1956:
1948:
1901:
1858:
1821:
1780:
1646:
1520:
1463:
neovascularization. It is also a key regulator of growth plate formation- both growth plate
1363:
1323:
470:
401:
345:
300:
3531:
3293:"PGE2 receptor agonist misoprostol protects brain against intracerebral hemorrhage in mice"
4186:
4170:
4083:
3692:
1650:
1413:
445:
221:
3308:
2844:
Newman KM, Ogata Y, Malon AM, Irizarry E, Gandhi RH, Nagase H, Tilson MD (August 1994).
2805:"Changes in matrix metalloproteinase-9 levels during progression of atrial fibrillation"
2427:
Ramos-DeSimone N, Hahn-Dantona E, Sipley J, Nagase H, French DL, Quigley JP (May 1999).
628:
4335:
4224:
4165:
3465:
3440:
3422:
3397:
3317:
3292:
3208:
3183:
3128:
3103:
3001:
2976:
2696:
2669:
2366:
2341:
2233:
2208:
2184:
2159:
2135:
2110:
1961:
1936:
1751:"Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)"
1566:
1508:
1315:
3238:
2952:
2935:
2911:
2886:
2597:
2224:
2175:
932:
927:
922:
917:
912:
907:
902:
897:
892:
887:
882:
877:
872:
867:
862:
857:
852:
847:
842:
837:
832:
827:
822:
817:
812:
807:
802:
797:
792:
787:
782:
766:
761:
756:
751:
746:
741:
736:
720:
715:
710:
705:
700:
695:
690:
685:
680:
675:
670:
28:
4345:
4129:
4088:
3546:
2482:
1553:
Activation is achieved through an interacting protease cascade involving plasmin and
1407:
1403:
1367:
928:
negative regulation of epithelial cell differentiation involved in kidney development
657:
3511:
3359:
3104:"Toxic role of prostaglandin E2 receptor EP1 after intracerebral hemorrhage in mice"
2934:
Lindeman JH, Abdul-Hussien H, van Bockel JH, Wolterbeek R, Kleemann R (April 2009).
2748:
2498:
2285:
2068:
Dubois B, Starckx S, Pagenstecher A, Oord Jv, Arnold B, Opdenakker G (August 2002).
2054:
1921:
1878:
4078:
3413:
2405:
1501:
1464:
1359:
1355:
463:
242:
3283:
3174:
2613:
205:
3199:
3041:
1862:
229:
4302:
4237:
4073:
4007:
3992:
3837:
3439:
Wu H, Wu T, Han X, Wan J, Jiang C, Chen W, Lu H, Yang Q, Wang J (January 2017).
1997:
1734:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1716:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1626:
1574:
1468:
4330:
2357:
1952:
546:
3982:
3854:
3495:
3343:
3158:
3119:
2975:
Apoorv TS, Babu PP, Meese S, Gai PP, Bedu-Addo G, Mockenhaupt FP (July 2015).
2733:
10.1002/1097-0142(19950815)76:4<700::aid-cncr2820760426>3.0.co;2-5
1905:
1570:
1545:
1516:
1505:
1480:
1429:
1395:
1391:
1387:
1319:
362:
259:
209:
3456:
3267:
3085:
3068:
2862:
2845:
2821:
2804:
2445:
2428:
1785:
1768:
4276:
4250:
1532:
1512:
1444:
1379:
962:
606:
484:
429:
416:
328:
315:
217:
3503:
3474:
3431:
3388:
3351:
3326:
3275:
3246:
3217:
3166:
3137:
3094:
3049:
3010:
2961:
2920:
2830:
2789:
2705:
2686:
2654:
2562:
2526:
2454:
2413:
2375:
2326:
2317:
2300:
2242:
2144:
2126:
2095:
2046:
1970:
1913:
1870:
1835:
1826:
1809:
1794:
888:
positive regulation of vascular associated smooth muscle cell proliferation
3623:: Crystal structure of human matrix metalloproteinase MMP9 (gelatinase B).
2992:
2871:
2780:
2763:
2740:
2605:
2570:
2534:
2490:
2277:
2270:
10.1002/(sici)1097-4652(199602)166:2<413::aid-jcp20>3.0.co;2-a
2193:
2005:
1264:
1259:
4017:
3819:
3814:
3809:
3664:
2037:
2020:
1440:
1399:
1371:
1248:
1107:
1088:
873:
positive regulation of epidermal growth factor receptor signaling pathway
3380:
3182:
Wu H, Zhang Z, Li Y, Zhao R, Li H, Song Y, Qi J, Wang J (October 2010).
3804:
3799:
3794:
3789:
3784:
3779:
3774:
3551:
3541:
2087:
10.1002/1521-4141(200208)32:8<2163::AID-IMMU2163>3.0.CO;2-Q
2021:"Gelatinase B functions as regulator and effector in leukocyte biology"
1074:
1029:
3396:
Wu H, Zhang Z, Hu X, Zhao R, Song Y, Ban X, Qi J, Wang J (June 2010).
2346:
American
Journal of Physiology. Lung Cellular and Molecular Physiology
150:
146:
142:
138:
134:
130:
126:
122:
118:
114:
110:
106:
102:
98:
94:
90:
86:
82:
78:
74:
4289:
4059:
3941:
3769:
3764:
3759:
3754:
3749:
3744:
3739:
3734:
3712:
3707:
3702:
3527:
1539:
1460:
1448:
1375:
1292:
1232:
984:
2902:
2646:
10.1002/1097-0215(20000801)87:3<336::aid-ijc5>3.3.co;2-v
1492:
4263:
3966:
3961:
3956:
3951:
3946:
3931:
3926:
3921:
3916:
3911:
3906:
3901:
3886:
3881:
3729:
3724:
3719:
3697:
1491:
947:
943:
3876:
3871:
3859:
3847:
3842:
1558:
1554:
1535:
1428:
MMP9, along with elastase, appears to be a regulatory factor in
1311:
1296:
858:
positive regulation of release of cytochrome c from mitochondria
197:
4032:
3637:
3561:
2762:
Groblewska M, Siewko M, Mroczko B, Szmitkowski M (April 2012).
637:
3557:
3536:
Overview of all the structural information available in the
813:
negative regulation of intrinsic apoptotic signaling pathway
2670:"Gelatinase B/MMP-9 in Tumour Pathogenesis and Progression"
4028:
2070:"Gelatinase B deficiency protects against endotoxin shock"
1986:
American
Journal of Respiratory Cell and Molecular Biology
1557:. Plasmin generates active MMP-3 from its zymogen. Active
1398:. The enzyme encoded by this gene degrades type IV and V
1618:
MMP9 levels increase with the progression of idiopathic
453:
1527:
are conserved. Its primary structure comprises several
2803:
Li M, Yang G, Xie B, Babu K, Huang C (February 2014).
1894:
Critical
Reviews in Biochemistry and Molecular Biology
1851:
Critical Reviews in Biochemistry and Molecular Biology
4319:
3530:
online database for peptidases and their inhibitors:
2981:
The American Journal of Tropical Medicine and Hygiene
1479:
MMP9 is greatly upregulated during human respiratory
618:
1511:
and secreted as an inactive pro-MMP. The human MMP9
4215:
4179:
4148:
4117:
4066:
3975:
3828:
3683:
1193:
1172:
1146:
1125:
1690:
1688:
1686:
1669:
1667:
1665:
1593:Elevated MMP9 levels can be found in the cases of
1394:which are activated when cleaved by extracellular
400:
299:
1633:Pregnancy-associated malaria (Placental malaria)
1378:, as well as in pathological processes, such as
3608:: Dimeric form of the haemopexin domain of MMP9
16:Protein-coding gene in the species Homo sapiens
3256:Current Drug Targets. Inflammation and Allergy
1695:GRCm38: Ensembl release 89: ENSMUSG00000017737
1346:(MMP) family are involved in the breakdown of
793:positive regulation of protein phosphorylation
788:negative regulation of cation channel activity
4044:
3649:
3573:
3445:Journal of Cerebral Blood Flow and Metabolism
2809:The Journal of International Medical Research
1515:consists of five domains. The amino-terminal
843:positive regulation of keratinocyte migration
8:
2387:
2385:
1653:dysfunction exhibit higher levels of MMP-9.
908:cellular response to reactive oxygen species
1674:GRCh38: Ensembl release 89: ENSG00000100985
1573:. Each blade consists of four antiparallel
1504:of 707 amino-acid residues, including a 19
1350:in normal physiological processes, such as
4051:
4037:
4029:
3656:
3642:
3634:
3580:
3566:
3558:
1303:family involved in the degradation of the
958:
653:
441:
340:
237:
63:
3464:
3421:
3316:
3207:
3127:
3084:
3000:
2951:
2910:
2861:
2820:
2779:
2695:
2685:
2644:
2444:
2365:
2316:
2232:
2183:
2134:
2085:
2036:
1960:
1825:
1784:
1762:
1760:
1745:
1743:
1544:
923:regulation of neuroinflammatory response
848:positive regulation of apoptotic process
828:negative regulation of apoptotic process
767:collagen-containing extracellular matrix
4326:
3595:
2551:Clinical Immunology and Immunopathology
1661:
1525:carboxyl-terminal hemopexin-like domain
863:positive regulation of receptor binding
18:
3998:Pregnancy-associated plasma protein A
2891:The Journal of Clinical Investigation
2668:Farina AR, Mackay AR (January 2014).
1390:. Most MMPs are secreted as inactive
898:positive regulation of cell migration
405:
366:
361:
304:
263:
258:
7:
3550:(Matrix metalloproteinase-9) at the
3336:Journal of the Neurological Sciences
3309:10.1016/j.neurobiolaging.2014.12.029
3073:The Journal of Biological Chemistry
3067:Nagase H, Woessner JF (July 1999).
2768:Folia Histochemica et Cytobiologica
2433:The Journal of Biological Chemistry
2305:The Journal of Biological Chemistry
1773:The Journal of Biological Chemistry
1767:Nagase H, Woessner JF (July 1999).
1467:and the generation of hypertrophic
918:cytokine-mediated signaling pathway
3227:Journal of Reproductive Immunology
1941:American Journal of Human Genetics
1291:(GELB), is a matrixin, a class of
1190:
1169:
1143:
1122:
1098:
1079:
1053:
1034:
1008:
989:
868:positive regulation of DNA binding
716:serine-type endopeptidase activity
623:
541:
479:
458:
14:
2953:10.1161/CIRCULATIONAHA.108.806505
893:extracellular matrix organization
818:ephrin receptor signaling pathway
4329:
3613:
3598:
3369:Biochemical Society Transactions
1332:C-terminal hemopexin-like domain
913:cellular response to cadmium ion
823:extracellular matrix disassembly
627:
389:
382:
376:
353:
288:
281:
275:
250:
27:
2850:Arteriosclerosis and Thrombosis
2633:International Journal of Cancer
1808:Wang J, Tsirka SE (July 2005).
1326:with inserted three repeats of
798:endodermal cell differentiation
3484:Journal of Clinical Immunology
3414:10.1016/j.brainres.2010.04.033
2406:10.1016/j.chembiol.2014.01.008
2258:Journal of Cellular Physiology
2074:European Journal of Immunology
638:More reference expression data
607:More reference expression data
1:
3239:10.1016/S0165-0378(01)00142-5
3108:Brain, Behavior, and Immunity
2598:10.1016/s0304-3940(97)00859-8
2225:10.1016/s0092-8674(02)00754-7
2176:10.1016/s0092-8674(00)81169-1
721:metalloendopeptidase activity
374:
273:
4352:Genes on human chromosome 20
4003:Bone morphogenetic protein 1
3200:10.1016/j.neuint.2010.06.002
3188:Neurochemistry International
3042:10.1016/j.ophtha.2016.07.028
2515:Journal of Molecular Biology
2483:10.1016/0014-5793(93)80312-I
2025:Journal of Leukocyte Biology
1863:10.3109/10409238.2013.770819
757:ficolin-1-rich granule lumen
3069:"Matrix metalloproteinases"
1998:10.1165/ajrcmb.14.3.8845180
1769:"Matrix metalloproteinases"
783:skeletal system development
4378:
2358:10.1152/ajplung.00015.2014
1953:10.1016/j.ajhg.2008.03.013
1649:patients, especially with
1597:and focal brain ischemia.
1443:, and cleavage of several
1328:fibronectin type II domain
1281:92 kDa type IV collagenase
1277:Matrix metalloproteinase-9
853:collagen catabolic process
838:macrophage differentiation
4357:Matrix metalloproteinases
4207:Michaelis–Menten kinetics
3830:Matrix metalloproteinases
3593:
3496:10.1007/s10875-006-9022-6
3344:10.1016/j.jns.2004.11.041
3159:10.1080/10428190290005982
3120:10.1016/j.bbi.2015.02.011
2115:British Journal of Cancer
1906:10.1080/10409230290771546
1730:"Mouse PubMed Reference:"
1712:"Human PubMed Reference:"
1406:-induced mobilization of
1263:
1258:
1254:
1247:
1231:
1212:
1197:
1176:
1165:
1150:
1129:
1118:
1105:
1101:
1086:
1082:
1073:
1060:
1056:
1041:
1037:
1028:
1015:
1011:
996:
992:
983:
968:
961:
957:
941:
706:metallopeptidase activity
696:identical protein binding
656:
652:
635:
626:
617:
604:
553:
544:
491:
482:
452:
444:
440:
423:
410:
373:
352:
343:
339:
322:
309:
272:
249:
240:
236:
191:
188:
178:
171:
166:
71:
66:
49:
44:
39:
35:
26:
21:
4099:Diffusion-limited enzyme
4013:Insulin-degrading enzyme
3457:10.1177/0271678X15625351
3268:10.2174/1568010033484133
3086:10.1074/jbc.274.31.21491
2863:10.1161/01.atv.14.8.1315
2822:10.1177/0300060513488514
2446:10.1074/jbc.274.19.13066
1786:10.1074/jbc.274.31.21491
1384:intracerebral hemorrhage
1344:matrix metalloproteinase
1225:Chr 2: 164.78 – 164.8 Mb
1218:Chr 20: 46.01 – 46.02 Mb
933:response to amyloid-beta
903:neutrophil degranulation
577:bones of pectoral girdle
3147:Leukemia & Lymphoma
2394:Chemistry & Biology
1542:in an inactive state.
1500:MMP9 is synthesized as
1279:(MMP-9), also known as
2687:10.3390/cancers6010240
2563:10.1006/clin.1996.0025
2527:10.1006/jmbi.1996.0661
2318:10.1074/jbc.m107611200
2127:10.1038/sj.bjc.6690291
1550:
1497:
752:tertiary granule lumen
711:endopeptidase activity
593:trophoblast giant cell
4192:Eadie–Hofstee diagram
4125:Allosteric regulation
3988:Procollagen peptidase
3669:metalloendopeptidases
3297:Neurobiology of Aging
2993:10.4269/ajtmh.14-0816
2781:10.5603/fhc.2012.0002
1581:Clinical significance
1555:stromelysin 1 (MMP-3)
1548:
1495:
1432:migration across the
1352:embryonic development
742:extracellular exosome
266:Chromosome 20 (human)
4202:Lineweaver–Burk plot
2586:Neuroscience Letters
2038:10.1189/jlb.69.6.851
1827:10.1093/brain/awh489
1595:rheumatoid arthritis
1348:extracellular matrix
1305:extracellular matrix
762:extracellular region
737:extracellular matrix
407:2 H3|2 85.27 cM
368:Chromosome 2 (mouse)
67:List of PDB id codes
40:Available structures
3381:10.1042/BST20051135
3338:. 229–230: 249–54.
1620:atrial fibrillation
1519:, the zinc-binding
1295:that belong to the
883:leukocyte migration
878:embryo implantation
747:extracellular space
4161:Enzyme superfamily
4094:Enzyme promiscuity
2121:(11–12): 1828–35.
1551:
1498:
1370:, cell migration,
1301:metalloproteinases
1063:ENSMUSG00000017737
776:Biological process
730:Cellular component
701:hydrolase activity
686:peptidase activity
664:Molecular function
561:tibiofemoral joint
4317:
4316:
4026:
4025:
3631:
3630:
3036:(11): 2300–2308.
1820:(Pt 7): 1622–33.
1434:basement membrane
1424:Neutrophil action
1285:92 kDa gelatinase
1274:
1273:
1270:
1269:
1243:
1242:
1208:
1207:
1187:
1186:
1161:
1160:
1140:
1139:
1114:
1113:
1095:
1094:
1069:
1068:
1050:
1049:
1024:
1023:
1005:
1004:
953:
952:
681:metal ion binding
648:
647:
644:
643:
613:
612:
600:
599:
538:
537:
511:bone marrow cells
495:periodontal fiber
436:
435:
335:
334:
162:
161:
158:
157:
50:Ortholog search:
4369:
4334:
4333:
4325:
4197:Hanes–Woolf plot
4140:Enzyme activator
4135:Enzyme inhibitor
4109:Enzyme catalysis
4053:
4046:
4039:
4030:
3693:Alpha secretases
3658:
3651:
3644:
3635:
3617:
3602:
3582:
3575:
3568:
3559:
3515:
3478:
3468:
3435:
3425:
3392:
3375:(Pt 5): 1135–6.
3363:
3330:
3320:
3287:
3250:
3221:
3211:
3178:
3141:
3131:
3098:
3088:
3054:
3053:
3021:
3015:
3014:
3004:
2972:
2966:
2965:
2955:
2931:
2925:
2924:
2914:
2882:
2876:
2875:
2865:
2841:
2835:
2834:
2824:
2800:
2794:
2793:
2783:
2759:
2753:
2752:
2716:
2710:
2709:
2699:
2689:
2665:
2659:
2658:
2648:
2624:
2618:
2617:
2581:
2575:
2574:
2545:
2539:
2538:
2509:
2503:
2502:
2465:
2459:
2458:
2448:
2439:(19): 13066–76.
2424:
2418:
2417:
2389:
2380:
2379:
2369:
2352:(11): L1006-15.
2337:
2331:
2330:
2320:
2296:
2290:
2289:
2253:
2247:
2246:
2236:
2204:
2198:
2197:
2187:
2155:
2149:
2148:
2138:
2106:
2100:
2099:
2089:
2065:
2059:
2058:
2040:
2016:
2010:
2009:
1981:
1975:
1974:
1964:
1932:
1926:
1925:
1889:
1883:
1882:
1846:
1840:
1839:
1829:
1805:
1799:
1798:
1788:
1764:
1755:
1754:
1747:
1738:
1737:
1726:
1720:
1719:
1708:
1702:
1692:
1681:
1671:
1538:to maintain the
1521:catalytic domain
1364:bone development
1342:Proteins of the
1324:catalytic domain
1307:. In humans the
1256:
1255:
1227:
1220:
1203:
1191:
1182:
1170:
1166:RefSeq (protein)
1156:
1144:
1135:
1123:
1099:
1080:
1054:
1035:
1009:
990:
959:
676:zinc ion binding
671:collagen binding
654:
640:
631:
624:
609:
549:
547:Top expressed in
542:
523:cartilage tissue
487:
485:Top expressed in
480:
459:
442:
432:
419:
408:
393:
386:
380:
369:
357:
341:
331:
318:
307:
292:
285:
279:
268:
254:
238:
232:
230:MMP9 - orthologs
183:
176:
153:
64:
58:
37:
36:
31:
19:
4377:
4376:
4372:
4371:
4370:
4368:
4367:
4366:
4342:
4341:
4340:
4328:
4320:
4318:
4313:
4225:Oxidoreductases
4211:
4187:Enzyme kinetics
4175:
4171:List of enzymes
4144:
4113:
4084:Catalytic triad
4062:
4057:
4027:
4022:
3971:
3824:
3679:
3662:
3632:
3627:
3624:
3618:
3609:
3603:
3589:
3586:
3523:
3518:
3481:
3438:
3395:
3366:
3333:
3290:
3253:
3224:
3181:
3144:
3101:
3079:(31): 21491–4.
3066:
3062:
3060:Further reading
3057:
3023:
3022:
3018:
2974:
2973:
2969:
2946:(16): 2209–16.
2933:
2932:
2928:
2903:10.1172/jci8931
2884:
2883:
2879:
2843:
2842:
2838:
2802:
2801:
2797:
2761:
2760:
2756:
2718:
2717:
2713:
2667:
2666:
2662:
2626:
2625:
2621:
2583:
2582:
2578:
2547:
2546:
2542:
2511:
2510:
2506:
2477:(1–2): 134–40.
2467:
2466:
2462:
2426:
2425:
2421:
2391:
2390:
2383:
2339:
2338:
2334:
2298:
2297:
2293:
2255:
2254:
2250:
2206:
2205:
2201:
2157:
2156:
2152:
2108:
2107:
2103:
2067:
2066:
2062:
2018:
2017:
2013:
1983:
1982:
1978:
1934:
1933:
1929:
1891:
1890:
1886:
1848:
1847:
1843:
1807:
1806:
1802:
1779:(31): 21491–4.
1766:
1765:
1758:
1749:
1748:
1741:
1728:
1727:
1723:
1710:
1709:
1705:
1693:
1684:
1672:
1663:
1659:
1651:meibomian gland
1644:
1635:
1616:
1603:
1591:
1583:
1490:
1477:
1457:
1426:
1414:Thrombospondins
1340:
1265:View/Edit Mouse
1260:View/Edit Human
1223:
1216:
1213:Location (UCSC)
1199:
1178:
1152:
1131:
1044:ENSG00000100985
937:
771:
725:
691:protein binding
636:
605:
596:
591:
587:
583:
579:
575:
571:
567:
563:
559:
545:
534:
529:
525:
521:
517:
513:
509:
505:
501:
499:trabecular bone
497:
483:
427:
414:
406:
396:
395:
394:
387:
367:
344:Gene location (
326:
313:
305:
295:
294:
293:
286:
264:
241:Gene location (
192:
179:
172:
73:
51:
17:
12:
11:
5:
4375:
4373:
4365:
4364:
4359:
4354:
4344:
4343:
4339:
4338:
4315:
4314:
4312:
4311:
4298:
4285:
4272:
4259:
4246:
4233:
4219:
4217:
4213:
4212:
4210:
4209:
4204:
4199:
4194:
4189:
4183:
4181:
4177:
4176:
4174:
4173:
4168:
4163:
4158:
4152:
4150:
4149:Classification
4146:
4145:
4143:
4142:
4137:
4132:
4127:
4121:
4119:
4115:
4114:
4112:
4111:
4106:
4101:
4096:
4091:
4086:
4081:
4076:
4070:
4068:
4064:
4063:
4058:
4056:
4055:
4048:
4041:
4033:
4024:
4023:
4021:
4020:
4015:
4010:
4005:
4000:
3995:
3990:
3985:
3979:
3977:
3973:
3972:
3970:
3969:
3964:
3959:
3954:
3949:
3944:
3939:
3934:
3929:
3924:
3919:
3914:
3909:
3904:
3899:
3894:
3889:
3884:
3879:
3874:
3869:
3868:
3867:
3862:
3852:
3851:
3850:
3845:
3834:
3832:
3826:
3825:
3823:
3822:
3817:
3812:
3807:
3802:
3797:
3792:
3787:
3782:
3777:
3772:
3767:
3762:
3757:
3752:
3747:
3742:
3737:
3732:
3727:
3722:
3717:
3716:
3715:
3710:
3705:
3700:
3689:
3687:
3681:
3680:
3663:
3661:
3660:
3653:
3646:
3638:
3629:
3628:
3626:
3625:
3619:
3612:
3610:
3604:
3597:
3594:
3591:
3590:
3587:
3585:
3584:
3577:
3570:
3562:
3556:
3555:
3534:
3522:
3521:External links
3519:
3517:
3516:
3490:(4): 299–307.
3479:
3436:
3402:Brain Research
3393:
3364:
3331:
3303:(3): 1439–50.
3288:
3251:
3222:
3179:
3142:
3099:
3063:
3061:
3058:
3056:
3055:
3016:
2967:
2926:
2897:(11): 1641–9.
2877:
2856:(8): 1315–20.
2836:
2795:
2754:
2711:
2660:
2619:
2576:
2540:
2504:
2460:
2419:
2381:
2332:
2311:(3): 2065–72.
2291:
2248:
2199:
2150:
2101:
2080:(8): 2163–71.
2060:
2011:
1976:
1927:
1900:(6): 375–536.
1884:
1841:
1800:
1756:
1739:
1721:
1703:
1682:
1660:
1658:
1655:
1643:
1640:
1634:
1631:
1615:
1614:Cardiovascular
1612:
1602:
1599:
1590:
1587:
1582:
1579:
1569:blades and an
1509:signal peptide
1489:
1486:
1476:
1473:
1456:
1453:
1425:
1422:
1339:
1336:
1330:followed by a
1316:signal peptide
1314:encodes for a
1272:
1271:
1268:
1267:
1262:
1252:
1251:
1245:
1244:
1241:
1240:
1238:
1236:
1229:
1228:
1221:
1214:
1210:
1209:
1206:
1205:
1195:
1194:
1188:
1185:
1184:
1174:
1173:
1167:
1163:
1162:
1159:
1158:
1148:
1147:
1141:
1138:
1137:
1127:
1126:
1120:
1116:
1115:
1112:
1111:
1103:
1102:
1096:
1093:
1092:
1084:
1083:
1077:
1071:
1070:
1067:
1066:
1058:
1057:
1051:
1048:
1047:
1039:
1038:
1032:
1026:
1025:
1022:
1021:
1013:
1012:
1006:
1003:
1002:
994:
993:
987:
981:
980:
975:
970:
966:
965:
955:
954:
951:
950:
939:
938:
936:
935:
930:
925:
920:
915:
910:
905:
900:
895:
890:
885:
880:
875:
870:
865:
860:
855:
850:
845:
840:
835:
830:
825:
820:
815:
810:
805:
800:
795:
790:
785:
779:
777:
773:
772:
770:
769:
764:
759:
754:
749:
744:
739:
733:
731:
727:
726:
724:
723:
718:
713:
708:
703:
698:
693:
688:
683:
678:
673:
667:
665:
661:
660:
650:
649:
646:
645:
642:
641:
633:
632:
621:
615:
614:
611:
610:
602:
601:
598:
597:
595:
594:
590:
586:
582:
578:
574:
570:
569:Dermatocranium
566:
562:
558:
554:
551:
550:
539:
536:
535:
533:
532:
528:
524:
520:
516:
512:
508:
504:
500:
496:
492:
489:
488:
476:
475:
467:
456:
450:
449:
446:RNA expression
438:
437:
434:
433:
425:
421:
420:
412:
409:
404:
398:
397:
388:
381:
375:
371:
370:
365:
359:
358:
350:
349:
337:
336:
333:
332:
324:
320:
319:
311:
308:
303:
297:
296:
287:
280:
274:
270:
269:
262:
256:
255:
247:
246:
234:
233:
190:
186:
185:
177:
169:
168:
164:
163:
160:
159:
156:
155:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
4374:
4363:
4360:
4358:
4355:
4353:
4350:
4349:
4347:
4337:
4332:
4327:
4323:
4309:
4305:
4304:
4299:
4296:
4292:
4291:
4286:
4283:
4279:
4278:
4273:
4270:
4266:
4265:
4260:
4257:
4253:
4252:
4247:
4244:
4240:
4239:
4234:
4231:
4227:
4226:
4221:
4220:
4218:
4214:
4208:
4205:
4203:
4200:
4198:
4195:
4193:
4190:
4188:
4185:
4184:
4182:
4178:
4172:
4169:
4167:
4166:Enzyme family
4164:
4162:
4159:
4157:
4154:
4153:
4151:
4147:
4141:
4138:
4136:
4133:
4131:
4130:Cooperativity
4128:
4126:
4123:
4122:
4120:
4116:
4110:
4107:
4105:
4102:
4100:
4097:
4095:
4092:
4090:
4089:Oxyanion hole
4087:
4085:
4082:
4080:
4077:
4075:
4072:
4071:
4069:
4065:
4061:
4054:
4049:
4047:
4042:
4040:
4035:
4034:
4031:
4019:
4016:
4014:
4011:
4009:
4006:
4004:
4001:
3999:
3996:
3994:
3991:
3989:
3986:
3984:
3981:
3980:
3978:
3974:
3968:
3965:
3963:
3960:
3958:
3955:
3953:
3950:
3948:
3945:
3943:
3940:
3938:
3935:
3933:
3930:
3928:
3925:
3923:
3920:
3918:
3915:
3913:
3910:
3908:
3905:
3903:
3900:
3898:
3895:
3893:
3890:
3888:
3885:
3883:
3880:
3878:
3875:
3873:
3870:
3866:
3863:
3861:
3858:
3857:
3856:
3853:
3849:
3846:
3844:
3841:
3840:
3839:
3836:
3835:
3833:
3831:
3827:
3821:
3818:
3816:
3813:
3811:
3808:
3806:
3803:
3801:
3798:
3796:
3793:
3791:
3788:
3786:
3783:
3781:
3778:
3776:
3773:
3771:
3768:
3766:
3763:
3761:
3758:
3756:
3753:
3751:
3748:
3746:
3743:
3741:
3738:
3736:
3733:
3731:
3728:
3726:
3723:
3721:
3718:
3714:
3711:
3709:
3706:
3704:
3701:
3699:
3696:
3695:
3694:
3691:
3690:
3688:
3686:
3685:ADAM proteins
3682:
3677:
3674:
3670:
3666:
3659:
3654:
3652:
3647:
3645:
3640:
3639:
3636:
3622:
3616:
3611:
3607:
3601:
3596:
3592:
3583:
3578:
3576:
3571:
3569:
3564:
3563:
3560:
3553:
3549:
3548:
3543:
3539:
3535:
3533:
3529:
3525:
3524:
3520:
3513:
3509:
3505:
3501:
3497:
3493:
3489:
3485:
3480:
3476:
3472:
3467:
3462:
3458:
3454:
3450:
3446:
3442:
3437:
3433:
3429:
3424:
3419:
3415:
3411:
3407:
3403:
3399:
3394:
3390:
3386:
3382:
3378:
3374:
3370:
3365:
3361:
3357:
3353:
3349:
3345:
3341:
3337:
3332:
3328:
3324:
3319:
3314:
3310:
3306:
3302:
3298:
3294:
3289:
3285:
3281:
3277:
3273:
3269:
3265:
3262:(3): 206–15.
3261:
3257:
3252:
3248:
3244:
3240:
3236:
3233:(1–2): 3–10.
3232:
3228:
3223:
3219:
3215:
3210:
3205:
3201:
3197:
3194:(3): 248–53.
3193:
3189:
3185:
3180:
3176:
3172:
3168:
3164:
3160:
3156:
3153:(2): 233–41.
3152:
3148:
3143:
3139:
3135:
3130:
3125:
3121:
3117:
3113:
3109:
3105:
3100:
3096:
3092:
3087:
3082:
3078:
3074:
3070:
3065:
3064:
3059:
3051:
3047:
3043:
3039:
3035:
3031:
3030:Ophthalmology
3027:
3020:
3017:
3012:
3008:
3003:
2998:
2994:
2990:
2986:
2982:
2978:
2971:
2968:
2963:
2959:
2954:
2949:
2945:
2941:
2937:
2930:
2927:
2922:
2918:
2913:
2908:
2904:
2900:
2896:
2892:
2888:
2881:
2878:
2873:
2869:
2864:
2859:
2855:
2851:
2847:
2840:
2837:
2832:
2828:
2823:
2818:
2815:(1): 224–30.
2814:
2810:
2806:
2799:
2796:
2791:
2787:
2782:
2777:
2773:
2769:
2765:
2758:
2755:
2750:
2746:
2742:
2738:
2734:
2730:
2726:
2722:
2715:
2712:
2707:
2703:
2698:
2693:
2688:
2683:
2680:(1): 240–96.
2679:
2675:
2671:
2664:
2661:
2656:
2652:
2647:
2642:
2639:(3): 336–42.
2638:
2634:
2630:
2623:
2620:
2615:
2611:
2607:
2603:
2599:
2595:
2592:(1–2): 53–6.
2591:
2587:
2580:
2577:
2572:
2568:
2564:
2560:
2557:(2): 161–71.
2556:
2552:
2544:
2541:
2536:
2532:
2528:
2524:
2521:(3): 556–66.
2520:
2516:
2508:
2505:
2500:
2496:
2492:
2488:
2484:
2480:
2476:
2472:
2464:
2461:
2456:
2452:
2447:
2442:
2438:
2434:
2430:
2423:
2420:
2415:
2411:
2407:
2403:
2400:(3): 408–13.
2399:
2395:
2388:
2386:
2382:
2377:
2373:
2368:
2363:
2359:
2355:
2351:
2347:
2343:
2336:
2333:
2328:
2324:
2319:
2314:
2310:
2306:
2302:
2295:
2292:
2287:
2283:
2279:
2275:
2271:
2267:
2264:(2): 413–26.
2263:
2259:
2252:
2249:
2244:
2240:
2235:
2230:
2226:
2222:
2219:(5): 625–37.
2218:
2214:
2210:
2203:
2200:
2195:
2191:
2186:
2181:
2177:
2173:
2170:(3): 411–22.
2169:
2165:
2161:
2154:
2151:
2146:
2142:
2137:
2132:
2128:
2124:
2120:
2116:
2112:
2105:
2102:
2097:
2093:
2088:
2083:
2079:
2075:
2071:
2064:
2061:
2056:
2052:
2048:
2044:
2039:
2034:
2030:
2026:
2022:
2015:
2012:
2007:
2003:
1999:
1995:
1992:(3): 288–95.
1991:
1987:
1980:
1977:
1972:
1968:
1963:
1958:
1954:
1950:
1947:(5): 1122–9.
1946:
1942:
1938:
1931:
1928:
1923:
1919:
1915:
1911:
1907:
1903:
1899:
1895:
1888:
1885:
1880:
1876:
1872:
1868:
1864:
1860:
1857:(3): 222–72.
1856:
1852:
1845:
1842:
1837:
1833:
1828:
1823:
1819:
1815:
1811:
1804:
1801:
1796:
1792:
1787:
1782:
1778:
1774:
1770:
1763:
1761:
1757:
1752:
1746:
1744:
1740:
1735:
1731:
1725:
1722:
1717:
1713:
1707:
1704:
1700:
1696:
1691:
1689:
1687:
1683:
1679:
1675:
1670:
1668:
1666:
1662:
1656:
1654:
1652:
1648:
1641:
1639:
1632:
1630:
1628:
1623:
1621:
1613:
1611:
1607:
1600:
1598:
1596:
1588:
1586:
1580:
1578:
1576:
1572:
1568:
1564:
1560:
1556:
1547:
1543:
1541:
1537:
1534:
1530:
1529:domain motifs
1526:
1522:
1518:
1514:
1510:
1507:
1503:
1494:
1487:
1485:
1482:
1474:
1472:
1470:
1466:
1462:
1454:
1452:
1450:
1446:
1442:
1437:
1435:
1431:
1423:
1421:
1419:
1415:
1411:
1409:
1408:hematopoietic
1405:
1401:
1397:
1393:
1389:
1385:
1381:
1377:
1373:
1369:
1368:wound healing
1365:
1361:
1357:
1353:
1349:
1345:
1337:
1335:
1333:
1329:
1325:
1321:
1317:
1313:
1310:
1306:
1302:
1298:
1294:
1290:
1286:
1282:
1278:
1266:
1261:
1257:
1253:
1250:
1246:
1239:
1237:
1234:
1230:
1226:
1222:
1219:
1215:
1211:
1204:
1202:
1196:
1192:
1189:
1183:
1181:
1175:
1171:
1168:
1164:
1157:
1155:
1149:
1145:
1142:
1136:
1134:
1128:
1124:
1121:
1119:RefSeq (mRNA)
1117:
1110:
1109:
1104:
1100:
1097:
1091:
1090:
1085:
1081:
1078:
1076:
1072:
1065:
1064:
1059:
1055:
1052:
1046:
1045:
1040:
1036:
1033:
1031:
1027:
1020:
1019:
1014:
1010:
1007:
1001:
1000:
995:
991:
988:
986:
982:
979:
976:
974:
971:
967:
964:
960:
956:
949:
945:
940:
934:
931:
929:
926:
924:
921:
919:
916:
914:
911:
909:
906:
904:
901:
899:
896:
894:
891:
889:
886:
884:
881:
879:
876:
874:
871:
869:
866:
864:
861:
859:
856:
854:
851:
849:
846:
844:
841:
839:
836:
834:
831:
829:
826:
824:
821:
819:
816:
814:
811:
809:
806:
804:
801:
799:
796:
794:
791:
789:
786:
784:
781:
780:
778:
775:
774:
768:
765:
763:
760:
758:
755:
753:
750:
748:
745:
743:
740:
738:
735:
734:
732:
729:
728:
722:
719:
717:
714:
712:
709:
707:
704:
702:
699:
697:
694:
692:
689:
687:
684:
682:
679:
677:
674:
672:
669:
668:
666:
663:
662:
659:
658:Gene ontology
655:
651:
639:
634:
630:
625:
622:
620:
616:
608:
603:
592:
588:
584:
580:
576:
572:
568:
565:body of femur
564:
560:
556:
555:
552:
548:
543:
540:
530:
526:
522:
518:
514:
510:
506:
502:
498:
494:
493:
490:
486:
481:
478:
477:
474:
472:
468:
466:
465:
461:
460:
457:
455:
451:
447:
443:
439:
431:
426:
422:
418:
413:
403:
399:
392:
385:
379:
372:
364:
360:
356:
351:
347:
342:
338:
330:
325:
321:
317:
312:
302:
298:
291:
284:
278:
271:
267:
261:
257:
253:
248:
244:
239:
235:
231:
227:
223:
219:
215:
211:
207:
203:
199:
195:
187:
182:
175:
170:
165:
154:
152:
148:
144:
140:
136:
132:
128:
124:
120:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
4303:Translocases
4300:
4287:
4274:
4261:
4248:
4238:Transferases
4235:
4222:
4079:Binding site
3864:
3838:Collagenases
3620:
3605:
3545:
3487:
3483:
3451:(1): 39–51.
3448:
3444:
3405:
3401:
3372:
3368:
3335:
3300:
3296:
3259:
3255:
3230:
3226:
3191:
3187:
3150:
3146:
3111:
3107:
3076:
3072:
3033:
3029:
3019:
2987:(1): 186–8.
2984:
2980:
2970:
2943:
2939:
2929:
2894:
2890:
2880:
2853:
2849:
2839:
2812:
2808:
2798:
2771:
2767:
2757:
2727:(4): 700–8.
2724:
2720:
2714:
2677:
2673:
2663:
2636:
2632:
2622:
2589:
2585:
2579:
2554:
2550:
2543:
2518:
2514:
2507:
2474:
2471:FEBS Letters
2470:
2463:
2436:
2432:
2422:
2397:
2393:
2349:
2345:
2335:
2308:
2304:
2294:
2261:
2257:
2251:
2216:
2212:
2202:
2167:
2163:
2153:
2118:
2114:
2104:
2077:
2073:
2063:
2031:(6): 851–9.
2028:
2024:
2014:
1989:
1985:
1979:
1944:
1940:
1930:
1897:
1893:
1887:
1854:
1850:
1844:
1817:
1813:
1803:
1776:
1772:
1733:
1724:
1715:
1706:
1645:
1636:
1624:
1617:
1608:
1604:
1592:
1584:
1552:
1502:preproenzyme
1499:
1478:
1475:Wound repair
1469:chondrocytes
1465:angiogenesis
1458:
1455:Angiogenesis
1438:
1427:
1420:remodeling.
1412:
1360:angiogenesis
1356:reproduction
1341:
1308:
1289:gelatinase B
1288:
1284:
1280:
1276:
1275:
1198:
1177:
1151:
1130:
1106:
1087:
1061:
1042:
1016:
997:
977:
972:
808:ossification
469:
462:
428:164,797,770
415:164,782,700
189:External IDs
72:
4074:Active site
4008:Lysostaphin
3993:Thermolysin
3855:Gelatinases
3588:PDB gallery
3114:: 293–310.
2940:Circulation
2774:(1): 12–9.
1627:Doxycycline
1567:β-propeller
1396:proteinases
1392:proproteins
833:proteolysis
557:granulocyte
527:skin of hip
507:bone marrow
327:46,016,561
314:46,008,908
167:Identifiers
4346:Categories
4277:Isomerases
4251:Hydrolases
4118:Regulation
3983:Neprilysin
1701:, May 2017
1680:, May 2017
1657:References
1517:propeptide
1506:amino acid
1481:epithelial
1445:chemokines
1430:neutrophil
1388:metastasis
1320:propeptide
531:lymph node
473:(ortholog)
210:HomoloGene
4362:EC 3.4.24
4156:EC number
3665:Proteases
3408:: 111–7.
1589:Arthritis
1575:β-strands
1563:substrate
1533:catalytic
1513:proenzyme
1488:Structure
1400:collagens
1380:arthritis
1201:NP_038627
1180:NP_004985
1154:NM_013599
1133:NM_004994
963:Orthologs
218:GeneCards
4180:Kinetics
4104:Cofactor
4067:Activity
4018:ZMPSTE24
3820:ADAMTS13
3815:ADAMTS12
3810:ADAMTS10
3512:19619963
3504:16652230
3475:26746866
3432:20420814
3389:16246065
3360:21791281
3352:15760647
3327:25623334
3276:14561155
3247:12062817
3218:20541575
3167:11999552
3138:25697396
3095:10419448
3050:27665213
3011:26013370
2962:19364980
2921:10841523
2831:24345823
2790:22532131
2749:41700819
2706:24473089
2655:10897037
2499:27244239
2455:10224058
2414:24583051
2376:24705725
2327:11689563
2286:24996115
2243:12062105
2145:10206300
2096:12209628
2055:15851048
2047:11404367
1971:18455130
1922:35833950
1914:12540195
1879:33781725
1871:23547785
1836:15800021
1795:10419448
1697:–
1676:–
1523:and the
1372:learning
1338:Function
1249:Wikidata
942:Sources:
573:mandible
515:appendix
306:20q13.12
4336:Biology
4290:Ligases
4060:Enzymes
3805:ADAMTS9
3800:ADAMTS8
3795:ADAMTS5
3790:ADAMTS4
3785:ADAMTS3
3780:ADAMTS2
3775:ADAMTS1
3552:PDBe-KB
3542:UniProt
3532:M10.009
3466:5363749
3423:2885522
3318:4417504
3209:2910823
3129:4422065
3002:4497894
2872:8049193
2741:8625169
2697:3980597
2674:Cancers
2606:9464653
2571:8625558
2535:8969305
2491:8405391
2367:4042193
2278:8592002
2234:2826110
2194:9590175
2185:2839071
2136:2362801
2006:8845180
1962:2427305
1699:Ensembl
1678:Ensembl
1647:Dry eye
1642:Dry eye
1571:α-helix
1293:enzymes
1075:UniProt
1030:Ensembl
969:Species
948:QuickGO
448:pattern
174:Aliases
4322:Portal
4264:Lyases
3942:MMP23B
3937:MMP23A
3770:ADAM33
3765:ADAM28
3760:ADAM23
3755:ADAM22
3750:ADAM18
3745:ADAM15
3740:ADAM12
3735:ADAM11
3713:ADAM19
3708:ADAM17
3703:ADAM10
3676:3.4.24
3547:P14780
3528:MEROPS
3510:
3502:
3473:
3463:
3430:
3420:
3387:
3358:
3350:
3325:
3315:
3284:453825
3282:
3274:
3245:
3216:
3206:
3175:940921
3173:
3165:
3136:
3126:
3093:
3048:
3009:
2999:
2960:
2919:
2912:300851
2909:
2870:
2829:
2788:
2747:
2739:
2721:Cancer
2704:
2694:
2653:
2614:916260
2612:
2604:
2569:
2533:
2497:
2489:
2453:
2412:
2374:
2364:
2325:
2284:
2276:
2241:
2231:
2192:
2182:
2143:
2133:
2094:
2053:
2045:
2004:
1969:
1959:
1920:
1912:
1877:
1869:
1834:
1793:
1601:Cancer
1540:enzyme
1461:glioma
1449:sepsis
1386:, and
1376:memory
1235:search
1233:PubMed
1108:P41245
1089:P14780
985:Entrez
619:BioGPS
198:120361
4216:Types
3976:Other
3967:MMP28
3962:MMP27
3957:MMP26
3952:MMP25
3947:MMP24
3932:MMP21
3927:MMP20
3922:MMP19
3917:MMP17
3912:MMP16
3907:MMP15
3902:MMP14
3897:MMP13
3892:MMP12
3887:MMP11
3882:MMP10
3730:ADAM8
3725:ADAM7
3720:ADAM2
3698:ADAM9
3508:S2CID
3356:S2CID
3280:S2CID
3171:S2CID
2745:S2CID
2610:S2CID
2495:S2CID
2282:S2CID
2051:S2CID
1918:S2CID
1875:S2CID
1814:Brain
1559:MMP-3
1441:IL-1β
1018:17395
978:Mouse
973:Human
944:Amigo
585:ankle
581:molar
519:blood
503:tibia
471:Mouse
464:Human
411:Start
346:Mouse
310:Start
243:Human
206:97011
4308:list
4301:EC7
4295:list
4288:EC6
4282:list
4275:EC5
4269:list
4262:EC4
4256:list
4249:EC3
4243:list
4236:EC2
4230:list
4223:EC1
3877:MMP7
3872:MMP3
3865:MMP9
3860:MMP2
3848:MMP8
3843:MMP1
3621:1l6j
3606:1itv
3540:for
3526:The
3500:PMID
3471:PMID
3428:PMID
3406:1342
3385:PMID
3348:PMID
3323:PMID
3272:PMID
3243:PMID
3214:PMID
3163:PMID
3134:PMID
3091:PMID
3046:PMID
3007:PMID
2958:PMID
2917:PMID
2868:PMID
2827:PMID
2786:PMID
2737:PMID
2702:PMID
2651:PMID
2602:PMID
2567:PMID
2531:PMID
2487:PMID
2451:PMID
2410:PMID
2372:PMID
2323:PMID
2274:PMID
2239:PMID
2213:Cell
2190:PMID
2164:Cell
2141:PMID
2092:PMID
2043:PMID
2002:PMID
1967:PMID
1910:PMID
1867:PMID
1832:PMID
1791:PMID
1536:zinc
1404:IL-8
1374:and
1322:, a
1318:, a
1312:gene
1309:MMP9
1297:zinc
999:4318
454:Bgee
402:Band
363:Chr.
301:Band
260:Chr.
222:MMP9
214:3659
194:OMIM
181:MMP9
151:5I12
147:5CUH
143:4XCT
139:4WZV
135:4JQG
131:4JIJ
127:4HMA
123:4H82
119:4H3X
115:4H2E
111:4H1Q
107:2OW2
103:2OW1
99:2OW0
95:2OVZ
91:2OVX
87:1L6J
83:1ITV
79:1GKD
75:1GKC
56:RCSB
53:PDBe
22:MMP9
3538:PDB
3492:doi
3461:PMC
3453:doi
3418:PMC
3410:doi
3377:doi
3340:doi
3313:PMC
3305:doi
3264:doi
3235:doi
3204:PMC
3196:doi
3155:doi
3124:PMC
3116:doi
3081:doi
3077:274
3038:doi
3034:123
2997:PMC
2989:doi
2948:doi
2944:119
2907:PMC
2899:doi
2895:105
2858:doi
2817:doi
2776:doi
2729:doi
2692:PMC
2682:doi
2641:doi
2594:doi
2590:238
2559:doi
2523:doi
2519:264
2479:doi
2475:331
2441:doi
2437:274
2402:doi
2362:PMC
2354:doi
2350:306
2313:doi
2309:277
2266:doi
2262:166
2229:PMC
2221:doi
2217:109
2180:PMC
2172:doi
2131:PMC
2123:doi
2082:doi
2033:doi
1994:doi
1957:PMC
1949:doi
1902:doi
1859:doi
1822:doi
1818:128
1781:doi
1777:274
1418:ECM
1287:or
589:rib
424:End
323:End
226:OMA
202:MGI
46:PDB
4348::
3673:EC
3667::
3544::
3506:.
3498:.
3488:26
3486:.
3469:.
3459:.
3449:37
3447:.
3443:.
3426:.
3416:.
3404:.
3400:.
3383:.
3373:33
3371:.
3354:.
3346:.
3321:.
3311:.
3301:36
3299:.
3295:.
3278:.
3270:.
3258:.
3241:.
3231:55
3229:.
3212:.
3202:.
3192:57
3190:.
3186:.
3169:.
3161:.
3151:43
3149:.
3132:.
3122:.
3112:46
3110:.
3106:.
3089:.
3075:.
3071:.
3044:.
3032:.
3028:.
3005:.
2995:.
2985:93
2983:.
2979:.
2956:.
2942:.
2938:.
2915:.
2905:.
2893:.
2889:.
2866:.
2854:14
2852:.
2848:.
2825:.
2813:42
2811:.
2807:.
2784:.
2772:50
2770:.
2766:.
2743:.
2735:.
2725:76
2723:.
2700:.
2690:.
2676:.
2672:.
2649:.
2637:87
2635:.
2631:.
2608:.
2600:.
2588:.
2565:.
2555:78
2553:.
2529:.
2517:.
2493:.
2485:.
2473:.
2449:.
2435:.
2431:.
2408:.
2398:21
2396:.
2384:^
2370:.
2360:.
2348:.
2344:.
2321:.
2307:.
2303:.
2280:.
2272:.
2260:.
2237:.
2227:.
2215:.
2211:.
2188:.
2178:.
2168:93
2166:.
2162:.
2139:.
2129:.
2119:79
2117:.
2113:.
2090:.
2078:32
2076:.
2072:.
2049:.
2041:.
2029:69
2027:.
2023:.
2000:.
1990:14
1988:.
1965:.
1955:.
1945:82
1943:.
1939:.
1916:.
1908:.
1898:37
1896:.
1873:.
1865:.
1855:48
1853:.
1830:.
1816:.
1812:.
1789:.
1775:.
1771:.
1759:^
1742:^
1732:.
1714:.
1685:^
1664:^
1622:.
1451:.
1436:.
1382:,
1366:,
1362:,
1358:,
1354:,
1334:.
946:/
430:bp
417:bp
329:bp
316:bp
224:;
220::
216:;
212::
208:;
204::
200:;
196::
149:,
145:,
141:,
137:,
133:,
129:,
125:,
121:,
117:,
113:,
109:,
105:,
101:,
97:,
93:,
89:,
85:,
81:,
77:,
4324::
4310:)
4306:(
4297:)
4293:(
4284:)
4280:(
4271:)
4267:(
4258:)
4254:(
4245:)
4241:(
4232:)
4228:(
4052:e
4045:t
4038:v
3678:)
3671:(
3657:e
3650:t
3643:v
3581:e
3574:t
3567:v
3554:.
3514:.
3494::
3477:.
3455::
3434:.
3412::
3391:.
3379::
3362:.
3342::
3329:.
3307::
3286:.
3266::
3260:2
3249:.
3237::
3220:.
3198::
3177:.
3157::
3140:.
3118::
3097:.
3083::
3052:.
3040::
3013:.
2991::
2964:.
2950::
2923:.
2901::
2874:.
2860::
2833:.
2819::
2792:.
2778::
2751:.
2731::
2708:.
2684::
2678:6
2657:.
2643::
2616:.
2596::
2573:.
2561::
2537:.
2525::
2501:.
2481::
2457:.
2443::
2416:.
2404::
2378:.
2356::
2329:.
2315::
2288:.
2268::
2245:.
2223::
2196:.
2174::
2147:.
2125::
2098:.
2084::
2057:.
2035::
2008:.
1996::
1973:.
1951::
1924:.
1904::
1881:.
1861::
1838:.
1824::
1797:.
1783::
1753:.
1736:.
1718:.
1299:-
1283:,
348:)
245:)
228::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
