255:
232:
129:
154:
261:
160:
1119:, another Rac protein which is expressed in neuronal cells, and this may be because Rac3 is primarily located in the perinuclear region. In fact, Rac1 and Rac3 appear to have distinct and antagonistic roles in these cells. Dock3-mediated Rac1 activation promotes reorganisation of the
1166:
The first indication that Dock3 might be involved in neurological disorders came when Dock3 was shown to bind to presenilin, a transmembrane enzyme involved in the generation of
1077:
Since Dock3 shares the same domain arrangement as Dock180 it is predicted to have a similar array of binding partners, although this has yet to be demonstrated. It contains an
1046:
Dock3 is part of a large class of proteins (GEFs) which contribute to cellular signalling events by activating small G proteins. In their resting state G proteins are bound to
268:
167:
1345:
Côté JF, Vuori K (December 2002). "Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity".
1170:(Aβ), accumulation of which is an important step in the development of Alzheimer's disease. Dock3 has been shown to undergo redistribution and association with
1621:"Disruption of a novel member of a sodium/hydrogen exchanger family and DOCK3 is associated with an attention deficit hyperactivity disorder-like phenotype"
675:
90:
656:
1179:
1258:
1240:
1914:
1065:(a member of the DOCK-A subfamily and the archetypal member of the DOCK family) and these proteins share a considerable (40%) degree of
254:
1089:
995:
880:
1572:"Presenilin Binding Protein Is Associated with Neurofibrillary Alterations in Alzheimer's Disease and Stimulates Tau Phosphorylation"
873:
1769:
231:
1276:
1227:
1206:
1223:
153:
128:
1174:
in brain samples from patients with
Alzheimer's disease. A mutation in Dock3 was also identified in a family displaying a
1202:
70:
267:
166:
260:
159:
720:
78:
1171:
701:
1051:
1023:
1831:
1047:
1019:
1752:
Côté JF, Vuori K (2006). "In Vitro
Guanine Nucleotide Exchange Activity of DHR-2/DOCKER/CZH2 Domains".
1390:"DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane"
1135:
142:
57:
1066:
1521:"Modifier of cell adhesion regulates N-cadherin-mediated cell-cell adhesion and neurite outgrowth"
1740:
1370:
1324:
102:
1151:
837:
811:
790:
1889:
1854:
1818:
1775:
1765:
1732:
1703:
1650:
1601:
1552:
1501:
1460:
1439:"Rac1 and Rac3 have opposing functions in cell adhesion and differentiation of neuronal cells"
1419:
1362:
1316:
50:
1879:
1846:
1808:
1800:
1757:
1724:
1693:
1685:
1640:
1632:
1591:
1583:
1542:
1532:
1491:
1450:
1409:
1401:
1354:
1306:
347:
278:
222:
177:
98:
1131:
1031:
999:
987:
322:
1813:
1788:
1698:
1673:
1645:
1620:
1596:
1571:
1547:
1520:
1311:
1294:
1085:
1058:
991:
1868:"Identification of genes related to Parkinson's disease using expressed sequence tags"
1761:
1587:
1414:
1389:
590:
585:
569:
564:
548:
543:
538:
1908:
1147:
1127:
984:
525:
1374:
1328:
82:
1744:
1537:
1167:
1120:
1003:
340:
119:
106:
1263:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1245:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1139:
1035:
1674:"GEF what? Dock180 and related proteins help Rac to polarize cells in new ways"
423:
1789:"A novel mechanism for the regulation of amyloid precursor protein metabolism"
1689:
1155:
1100:
1093:
1081:
1078:
1015:
239:
136:
86:
17:
1715:
Meller N, Merlot S, Guda C (2005). "CZH proteins: a new family of Rho-GEFs".
591:
positive regulation of non-membrane spanning protein tyrosine kinase activity
1884:
1867:
1175:
620:
483:
361:
306:
293:
205:
192:
94:
1893:
1858:
1822:
1779:
1736:
1707:
1654:
1605:
1556:
1505:
1496:
1479:
1464:
1437:
Hajdo-Milasinović A, Ellenbroek SI, van Es S, et al. (February 2007).
1366:
1320:
1050:(GDP) and their activation requires the dissociation of GDP and binding of
1804:
1636:
1423:
1405:
920:
915:
904:
765:
746:
1092:
which mediate recruitment and efficient GEF activity of Dock180), and a
1850:
1143:
1124:
1096:
1062:
1054:(GTP). GEFs activate G proteins by promoting this nucleotide exchange.
976:
732:
687:
1728:
1455:
1438:
1358:
1027:
888:
642:
1295:"Isolation and characterization of novel presenilin binding protein"
1014:
Dock3 was originally discovered in a screen for proteins that bind
605:
601:
1116:
1112:
74:
1619:
de Silva MG, Elliott K, Dahl HH, et al. (October 2003).
1570:
Chen Q, Yoshida H, Schubert D, et al. (November 2001).
1519:
Chen Q, Chen TJ, Letourneau PC, et al. (January 2005).
1388:
Hasegawa H, Kiyokawa E, Tanaka S, et al. (April 1996).
1099:-rich region which, in Dock180, binds the adaptor protein
1478:
Namekata K, Enokido Y, Iwasawa K, Kimura H (April 2004).
1756:. Methods in Enzymology. Vol. 406. pp. 41–57.
330:
1830:
Brion JP, Anderton BH, Authelet M, et al. (2001).
61:, MOCA, PBP, Dock3, dedicator of cytokinesis 3, NEDIDHA
1293:
Kashiwa A, Yoshida H, Lee S, et al. (July 2000).
1754:
Regulators and
Effectors of Small GTPases: Rho Family
495:
1480:"MOCA induces membrane spreading by activating Rac1"
1002:. Dock3 specifically activates the small G protein
851:
830:
804:
783:
434:
dentate gyrus of hippocampal formation granule cell
1219:
1217:
1215:
1198:
1196:
1194:
1832:"Neurofibrillary tangles and tau phosphorylation"
277:
176:
990:. It is a member of the DOCK-B subfamily of the
1277:"Entrez Gene: DOCK3 dedicator of cytokinesis 3"
1111:Dock3 GEF activity is directed specifically at
1288:
1286:
1224:GRCm38: Ensembl release 89: ENSMUSG00000039716
1866:Kim JM, Lee KH, Jeon YJ, et al. (2007).
8:
1115:. Dock3 has not been shown to interact with
1340:
1338:
1203:GRCh38: Ensembl release 89: ENSG00000088538
616:
549:guanyl-nucleotide exchange factor activity
521:
318:
217:
114:
1883:
1812:
1697:
1644:
1595:
1546:
1536:
1495:
1454:
1413:
1310:
586:small GTPase mediated signal transduction
1180:attention-deficit hyperactivity disorder
1190:
998:(GEFs) which function as activators of
1026:). Dock3 is specifically expressed in
31:
1787:Chen Q, Kimura H, Schubert D (2002).
1142:. It has also been shown to regulate
282:
243:
238:
181:
140:
135:
7:
996:guanine nucleotide exchange factors
1312:10.1046/j.1471-4159.2000.0750109.x
933:Dedicator of cytokinesis protein 3
848:
827:
801:
780:
756:
737:
711:
692:
666:
647:
500:
418:
356:
335:
25:
1022:which is mutated in early onset
266:
259:
253:
230:
165:
158:
152:
127:
975:rotein), is a large (~180 kDa)
1538:10.1523/JNEUROSCI.3692-04.2005
484:More reference expression data
408:dorsolateral prefrontal cortex
1:
1762:10.1016/S0076-6879(06)06004-6
1588:10.1016/S0002-9440(10)63005-2
251:
150:
979:encoded in the human by the
1915:Genes on human chromosome 3
380:paraflocculus of cerebellum
1931:
1690:10.1016/j.tcb.2007.05.001
1672:Côté JF, Vuori K (2007).
1259:"Mouse PubMed Reference:"
1241:"Human PubMed Reference:"
1162:In neurological disorders
1084:, which in Dock180 binds
919:
914:
910:
903:
887:
881:Chr 9: 106.77 – 107.11 Mb
868:
855:
834:
823:
808:
787:
776:
763:
759:
744:
740:
731:
718:
714:
699:
695:
686:
673:
669:
654:
650:
641:
626:
619:
615:
599:
524:
520:
508:
503:
494:
481:
430:
421:
368:
359:
329:
321:
317:
300:
287:
250:
229:
220:
216:
199:
186:
149:
126:
117:
113:
68:
65:
55:
48:
43:
39:
34:
1057:Dock3 exhibits the same
1172:neurofibrillary tangles
874:Chr 3: 50.67 – 51.38 Mb
27:Protein found in humans
1497:10.1074/jbc.M311275200
1052:guanosine triphosphate
1042:Structure and function
438:superior frontal gyrus
400:superior frontal gyrus
1885:10.1093/dnares/dsl016
1805:10.1083/jcb.200110151
1637:10.1136/jmg.40.10.733
1406:10.1128/mcb.16.4.1770
1107:Downstream signalling
1048:Guanosine diphosphate
1020:transmembrane protein
442:primary visual cortex
1134:neurones as well as
450:primary motor cortex
396:orbitofrontal cortex
384:middle frontal gyrus
245:Chromosome 9 (mouse)
143:Chromosome 3 (human)
1067:sequence similarity
1024:Alzheimer's disease
988:signalling networks
1851:10.1042/bss0670081
1839:Biochem. Soc. Symp
1723:(Pt 21): 4937–46.
1353:(Pt 24): 4901–13.
1148:cell-cell adhesion
1130:cells and primary
1030:(primarily in the
983:gene, involved in
721:ENSMUSG00000039716
579:Biological process
558:Cellular component
539:SH3 domain binding
532:Molecular function
454:olfactory tubercle
1729:10.1242/jcs.02671
1456:10.1242/jcs.03364
1359:10.1242/jcs.00219
939:), also known as
930:
929:
926:
925:
899:
898:
864:
863:
845:
844:
819:
818:
798:
797:
772:
771:
753:
752:
727:
726:
708:
707:
682:
681:
663:
662:
611:
610:
516:
515:
512:
511:
490:
489:
477:
476:
466:cerebellar cortex
462:prefrontal cortex
415:
414:
404:cerebellar vermis
388:postcentral gyrus
313:
312:
212:
211:
107:DOCK3 - orthologs
16:(Redirected from
1922:
1897:
1887:
1862:
1836:
1826:
1816:
1783:
1748:
1711:
1701:
1678:Trends Cell Biol
1659:
1658:
1648:
1616:
1610:
1609:
1599:
1567:
1561:
1560:
1550:
1540:
1516:
1510:
1509:
1499:
1490:(14): 14331–37.
1475:
1469:
1468:
1458:
1449:(Pt 4): 555–66.
1434:
1428:
1427:
1417:
1385:
1379:
1378:
1342:
1333:
1332:
1314:
1290:
1281:
1280:
1273:
1267:
1266:
1255:
1249:
1248:
1237:
1231:
1221:
1210:
1200:
1090:adaptor proteins
1000:small G-proteins
912:
911:
883:
876:
859:
849:
840:
828:
824:RefSeq (protein)
814:
802:
793:
781:
757:
738:
712:
693:
667:
648:
617:
522:
501:
486:
426:
424:Top expressed in
419:
392:Brodmann area 46
376:Brodmann area 10
364:
362:Top expressed in
357:
336:
319:
309:
296:
285:
270:
263:
257:
246:
234:
218:
208:
195:
184:
169:
162:
156:
145:
131:
115:
109:
60:
53:
32:
21:
1930:
1929:
1925:
1924:
1923:
1921:
1920:
1919:
1905:
1904:
1902:
1900:
1865:
1834:
1829:
1786:
1772:
1751:
1714:
1671:
1667:
1665:Further reading
1662:
1618:
1617:
1613:
1582:(5): 1567–602.
1569:
1568:
1564:
1518:
1517:
1513:
1477:
1476:
1472:
1436:
1435:
1431:
1394:Mol. Cell. Biol
1387:
1386:
1382:
1344:
1343:
1336:
1292:
1291:
1284:
1275:
1274:
1270:
1257:
1256:
1252:
1239:
1238:
1234:
1222:
1213:
1201:
1192:
1188:
1164:
1109:
1075:
1061:arrangement as
1044:
1032:cerebral cortex
1012:
921:View/Edit Mouse
916:View/Edit Human
879:
872:
869:Location (UCSC)
857:
836:
810:
789:
702:ENSG00000088538
595:
574:
553:
544:protein binding
482:
473:
468:
464:
460:
456:
452:
448:
446:piriform cortex
444:
440:
436:
422:
411:
406:
402:
398:
394:
390:
386:
382:
378:
374:
360:
304:
291:
283:
273:
272:
271:
264:
244:
221:Gene location (
203:
190:
182:
172:
171:
170:
163:
141:
118:Gene location (
69:
56:
49:
28:
23:
22:
15:
12:
11:
5:
1928:
1926:
1918:
1917:
1907:
1906:
1899:
1898:
1863:
1827:
1784:
1770:
1749:
1712:
1668:
1666:
1663:
1661:
1660:
1631:(10): 733–40.
1611:
1562:
1511:
1470:
1429:
1400:(4): 1770–76.
1380:
1334:
1282:
1268:
1250:
1232:
1211:
1189:
1187:
1184:
1163:
1160:
1146:outgrowth and
1108:
1105:
1074:
1071:
1043:
1040:
1011:
1008:
928:
927:
924:
923:
918:
908:
907:
901:
900:
897:
896:
894:
892:
885:
884:
877:
870:
866:
865:
862:
861:
853:
852:
846:
843:
842:
832:
831:
825:
821:
820:
817:
816:
806:
805:
799:
796:
795:
785:
784:
778:
774:
773:
770:
769:
761:
760:
754:
751:
750:
742:
741:
735:
729:
728:
725:
724:
716:
715:
709:
706:
705:
697:
696:
690:
684:
683:
680:
679:
671:
670:
664:
661:
660:
652:
651:
645:
639:
638:
633:
628:
624:
623:
613:
612:
609:
608:
597:
596:
594:
593:
588:
582:
580:
576:
575:
573:
572:
567:
561:
559:
555:
554:
552:
551:
546:
541:
535:
533:
529:
528:
518:
517:
514:
513:
510:
509:
506:
505:
498:
492:
491:
488:
487:
479:
478:
475:
474:
472:
471:
467:
463:
459:
455:
451:
447:
443:
439:
435:
431:
428:
427:
416:
413:
412:
410:
409:
405:
401:
397:
393:
389:
385:
381:
377:
373:
369:
366:
365:
353:
352:
344:
333:
327:
326:
323:RNA expression
315:
314:
311:
310:
302:
298:
297:
289:
286:
281:
275:
274:
265:
258:
252:
248:
247:
242:
236:
235:
227:
226:
214:
213:
210:
209:
201:
197:
196:
188:
185:
180:
174:
173:
164:
157:
151:
147:
146:
139:
133:
132:
124:
123:
111:
110:
67:
63:
62:
54:
46:
45:
41:
40:
37:
36:
26:
24:
18:MOCA (protein)
14:
13:
10:
9:
6:
4:
3:
2:
1927:
1916:
1913:
1912:
1910:
1903:
1895:
1891:
1886:
1881:
1878:(6): 275–86.
1877:
1873:
1869:
1864:
1860:
1856:
1852:
1848:
1845:(67): 81–88.
1844:
1840:
1833:
1828:
1824:
1820:
1815:
1810:
1806:
1802:
1798:
1794:
1790:
1785:
1781:
1777:
1773:
1771:9780121828110
1767:
1763:
1759:
1755:
1750:
1746:
1742:
1738:
1734:
1730:
1726:
1722:
1718:
1713:
1709:
1705:
1700:
1695:
1691:
1687:
1684:(8): 383–93.
1683:
1679:
1675:
1670:
1669:
1664:
1656:
1652:
1647:
1642:
1638:
1634:
1630:
1626:
1625:J. Med. Genet
1622:
1615:
1612:
1607:
1603:
1598:
1593:
1589:
1585:
1581:
1577:
1576:Am. J. Pathol
1573:
1566:
1563:
1558:
1554:
1549:
1544:
1539:
1534:
1531:(2): 281–90.
1530:
1526:
1522:
1515:
1512:
1507:
1503:
1498:
1493:
1489:
1485:
1484:J. Biol. Chem
1481:
1474:
1471:
1466:
1462:
1457:
1452:
1448:
1444:
1440:
1433:
1430:
1425:
1421:
1416:
1411:
1407:
1403:
1399:
1395:
1391:
1384:
1381:
1376:
1372:
1368:
1364:
1360:
1356:
1352:
1348:
1341:
1339:
1335:
1330:
1326:
1322:
1318:
1313:
1308:
1305:(1): 109–16.
1304:
1300:
1296:
1289:
1287:
1283:
1278:
1272:
1269:
1264:
1260:
1254:
1251:
1246:
1242:
1236:
1233:
1229:
1225:
1220:
1218:
1216:
1212:
1208:
1204:
1199:
1197:
1195:
1191:
1185:
1183:
1181:
1177:
1173:
1169:
1161:
1159:
1157:
1153:
1149:
1145:
1141:
1137:
1136:morphological
1133:
1129:
1128:neuroblastoma
1126:
1122:
1118:
1114:
1106:
1104:
1102:
1098:
1095:
1091:
1088:(a family of
1087:
1083:
1080:
1072:
1070:
1068:
1064:
1060:
1055:
1053:
1049:
1041:
1039:
1037:
1033:
1029:
1025:
1021:
1017:
1009:
1007:
1005:
1001:
997:
993:
989:
986:
985:intracellular
982:
978:
974:
970:
966:
962:
959:dhesion) and
958:
954:
950:
946:
942:
938:
934:
922:
917:
913:
909:
906:
902:
895:
893:
890:
886:
882:
878:
875:
871:
867:
860:
854:
850:
847:
841:
839:
833:
829:
826:
822:
815:
813:
807:
803:
800:
794:
792:
786:
782:
779:
777:RefSeq (mRNA)
775:
768:
767:
762:
758:
755:
749:
748:
743:
739:
736:
734:
730:
723:
722:
717:
713:
710:
704:
703:
698:
694:
691:
689:
685:
678:
677:
672:
668:
665:
659:
658:
653:
649:
646:
644:
640:
637:
634:
632:
629:
625:
622:
618:
614:
607:
603:
598:
592:
589:
587:
584:
583:
581:
578:
577:
571:
568:
566:
563:
562:
560:
557:
556:
550:
547:
545:
542:
540:
537:
536:
534:
531:
530:
527:
526:Gene ontology
523:
519:
507:
502:
499:
497:
493:
485:
480:
470:temporal lobe
469:
465:
461:
457:
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1799:(1): 79–89.
1796:
1793:J. Cell Biol
1792:
1753:
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1302:
1299:J. Neurochem
1298:
1271:
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1244:
1235:
1168:beta amyloid
1165:
1121:cytoskeleton
1110:
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674:
655:
635:
630:
372:frontal pole
346:
339:
305:107,109,108
292:106,770,024
66:External IDs
29:
1717:J. Cell Sci
1525:J. Neurosci
1443:J. Cell Sci
1347:J. Cell Sci
1178:resembling
1140:fibroblasts
1138:changes in
1036:hippocampus
284:9|9 F1
204:51,384,198
191:50,674,927
44:Identifiers
1230:, May 2017
1209:, May 2017
1186:References
1156:PC12 cells
1094:C-terminal
1082:SH3 domain
1079:N-terminal
1073:Regulation
1016:presenilin
994:family of
967:resenilin-
350:(ortholog)
87:HomoloGene
1176:phenotype
1010:Discovery
838:NP_004938
812:NM_153413
791:NM_004947
621:Orthologs
565:cytoplasm
95:GeneCards
1909:Category
1894:17213182
1859:11447842
1823:12093789
1780:16472648
1737:16254241
1708:17765544
1655:14569117
1606:11696419
1557:15647471
1506:14718541
1465:17244648
1375:14669715
1367:12432077
1329:24838995
1321:10854253
1226:–
1205:–
1182:(ADHD).
1132:cortical
947:odifier
905:Wikidata
600:Sources:
1872:DNA Res
1814:2173011
1745:3075895
1699:2887429
1646:1735283
1597:1867048
1548:6725471
1424:8657152
1228:Ensembl
1207:Ensembl
1144:neurite
1125:SH-SY5Y
1097:proline
1063:Dock180
1028:neurons
977:protein
971:inding
733:UniProt
688:Ensembl
627:Species
606:QuickGO
570:cytosol
325:pattern
83:2429763
51:Aliases
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1415:231163
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1327:
1319:
1059:domain
891:search
889:PubMed
766:Q8CIQ7
747:Q8IZD9
676:208869
643:Entrez
496:BioGPS
458:zygote
183:3p21.2
75:603123
1835:(PDF)
1741:S2CID
1371:S2CID
1325:S2CID
981:DOCK3
937:Dock3
636:Mouse
631:Human
602:Amigo
348:Mouse
341:Human
288:Start
223:Mouse
187:Start
120:Human
99:DOCK3
91:21030
58:DOCK3
35:DOCK3
1890:PMID
1855:PMID
1819:PMID
1776:PMID
1766:ISBN
1733:PMID
1704:PMID
1651:PMID
1602:PMID
1553:PMID
1502:PMID
1461:PMID
1420:PMID
1363:PMID
1317:PMID
1154:and
1152:B103
1117:Rac3
1113:Rac1
1086:ELMO
1034:and
992:DOCK
955:ell
941:MOCA
657:1795
331:Bgee
279:Band
240:Chr.
178:Band
137:Chr.
71:OMIM
1880:doi
1847:doi
1809:PMC
1801:doi
1797:158
1758:doi
1725:doi
1721:118
1694:PMC
1686:doi
1641:PMC
1633:doi
1592:PMC
1584:doi
1580:159
1543:PMC
1533:doi
1492:doi
1488:279
1451:doi
1447:120
1410:PMC
1402:doi
1355:doi
1351:115
1307:doi
1150:in
1123:in
1101:CRK
1038:).
1018:(a
1004:Rac
961:PBP
858:n/a
504:n/a
301:End
200:End
103:OMA
79:MGI
1911::
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