269:
1018:
189:
2204:
1933:
1043:
2385:
Campos Y, García-Redondo A, Fernández-Moreno MA, Martínez-Pardo M, Goda G, Rubio JC, Martín MA, del Hoyo P, Cabello A, Bornstein B, Garesse R, Arenas J (September 2001). "Early-onset multisystem mitochondrial disorder caused by a nonsense mutation in the mitochondrial DNA cytochrome C oxidase II
68:
2274:
Ostergaard E, Weraarpachai W, Ravn K, Born AP, Jønson L, Duno M, Wibrand F, Shoubridge EA, Vissing J (March 2015). "Mutations in COA3 cause isolated complex IV deficiency associated with neuropathy, exercise intolerance, obesity, and short stature".
2850:
Anderson S, Bankier AT, Barrell BG, de Bruijn MH, Coulson AR, Drouin J, Eperon IC, Nierlich DP, Roe BA, Sanger F, Schreier PH, Smith AJ, Staden R, Young IG (April 1981). "Sequence and organization of the human mitochondrial genome".
2804:
Chomyn A, Mariottini P, Cleeter MW, Ragan CI, Matsuno-Yagi A, Hatefi Y, Doolittle RF, Attardi G (1985). "Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase".
2592:
Lu X, Walker T, MacManus JP, Seligy VL (July 1992). "Differentiation of HT-29 human colonic adenocarcinoma cells correlates with increased expression of mitochondrial RNA: effects of trehalose on cell growth and maturation".
1950:
Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR, Apweiler R, Ge J, Hermjakob H, Ping P (October 2013).
2614:
Marzuki S, Noer AS, Lertrit P, Thyagarajan D, Kapsa R, Utthanaphol P, Byrne E (December 1991). "Normal variants of human mitochondrial DNA and translation products: the building of a reference data base".
3029:
Polyak K, Li Y, Zhu H, Lengauer C, Willson JK, Markowitz SD, Trush MA, Kinzler KW, Vogelstein B (November 1998). "Somatic mutations of the mitochondrial genome in human colorectal tumours".
2738:
Attardi G, Chomyn A, Doolittle RF, Mariottini P, Ragan CI (1987). "Seven unidentified reading frames of human mitochondrial DNA encode subunits of the respiratory chain NADH dehydrogenase".
2767:
Chomyn A, Cleeter MW, Ragan CI, Riley M, Doolittle RF, Attardi G (October 1986). "URF6, last unidentified reading frame of human mtDNA, codes for an NADH dehydrogenase subunit".
3293:
2429:
Clark KM, Taylor RW, Johnson MA, Chinnery PF, Chrzanowska-Lightowlers ZM, Andrews RM, Nelson IP, Wood NW, Lamont PJ, Hanna MG, Lightowlers RN, Turnbull DM (May 1999).
1491:(mammals). The N-terminal domain of cytochrome C oxidase contains two transmembrane alpha-helices. The structure of MT-CO2 is known to contain one redox center and a
1319:
1198:
2431:"An mtDNA mutation in the initiation codon of the cytochrome C oxidase subunit II gene results in lower levels of the protein and a mitochondrial encephalomyopathy"
1154:
1142:
4079:
3774:
764:
745:
150:
3769:
3860:
3442:
3528:
1901:
1110:
3337:
1883:
3286:
3066:
Kato MV (March 1999). "The mechanisms of death of an erythroleukemic cell line by p53: involvement of the microtubule and mitochondria".
268:
4099:
3628:
3563:
3573:
3398:
2896:
Montoya J, Ojala D, Attardi G (April 1981). "Distinctive features of the 5'-terminal sequences of the human mitochondrial mRNAs".
3899:
3697:
3332:
1926:
188:
3138:
Ingman M, Kaessmann H, Pääbo S, Gyllensten U (December 2000). "Mitochondrial genome variation and the origin of modern humans".
4114:
4066:
3894:
3558:
3279:
1870:
1849:
1596:
1528:
1446:
3889:
3675:
3633:
1552:
958:
1866:
1339:
1218:
965:
65:
1845:
3479:
3421:
3311:
1469:
130:
3533:
2483:
Torroni A, Achilli A, Macaulay V, Richards M, Bandelt HJ (June 2006). "Harvesting the fruit of the human mtDNA tree".
1623:
2336:
Rossmanith W, Freilinger M, Roka J, Raffelsberger T, Moser-Thier K, Prayer D, Bernert G, Bittner RE (February 2008).
3707:
3702:
3506:
3372:
4109:
3432:
1275:
202:
4104:
3623:
3501:
2147:
Hill BC (April 1993). "The sequence of electron carriers in the reaction of cytochrome c oxidase with oxygen".
1647:
1435:
1399:
809:
138:
1327:
1206:
3670:
3457:
1543:. MT-CO2 is one of the three subunits which are responsible for the formation of the functional core of the
790:
1017:
3665:
3322:
1761:
4039:
3779:
3655:
3491:
3469:
1532:
1323:
1202:
2943:"Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs"
1511:
at 204. Several bacterial MT-CO2 have a C-terminal extension that contains a covalently bound haem c.
121:, mitochondrially encoded cytochrome c oxidase II, COII, MTCO2, Cytochrome c oxidase subunit II, CO II
3880:
3786:
3643:
3592:
3538:
3147:
2954:
2905:
2860:
2814:
2776:
2521:
1753:
1701:
1681:
1643:
1592:
1544:
1524:
1431:
1383:
1123:
1048:
2512:
Barrell BG, Bankier AT, Drouin J (November 1979). "A different genetic code in human mitochondria".
1280:
117:
1619:
1564:
3810:
3578:
3452:
3171:
3126:
3054:
2929:
2884:
2838:
2640:
2545:
2411:
2300:
2172:
1729:
1667:
1655:
162:
1663:
941:
3800:
3603:
3384:
3259:
3214:
3163:
3118:
3083:
3046:
3017:
2982:
2921:
2876:
2830:
2792:
2755:
2726:
2683:
2632:
2602:
2580:
2537:
2500:
2460:
2403:
2367:
2292:
2256:
2164:
2129:
2094:
2040:
1982:
1713:
1705:
1685:
1651:
1631:
1419:
1387:
1314:
1193:
110:
58:
1688:
of a single nucleotide (7630delT) in the gene has been found to cause symptoms of reversible
3613:
3406:
3249:
3239:
3204:
3196:
3155:
3108:
3075:
3038:
3007:
2972:
2962:
2913:
2868:
2822:
2784:
2747:
2716:
2708:
2673:
2665:
2624:
2570:
2529:
2492:
2450:
2442:
2395:
2357:
2349:
2284:
2246:
2238:
2191:"MT-CO2 - Cytochrome c oxidase subunit 2 - Homo sapiens (Human) - MT-CO2 gene & protein"
2156:
2121:
2084:
2076:
2032:
1972:
1964:
1473:
1415:
361:
292:
259:
214:
31:
2023:
Capaldi RA, Malatesta F, Darley-Usmar VM (July 1983). "Structure of cytochrome c oxidase".
1306:
1185:
3518:
3411:
3095:
Andrews RM, Kubacka I, Chinnery PF, Lightowlers RN, Turnbull DM, Howell N (October 1999).
3012:
2995:
2212:
2203:
1789:
1639:
1568:
1480:
1465:
1442:
336:
158:
3097:"Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA"
3151:
2958:
2909:
2864:
2818:
2780:
2654:"Replication-competent human mitochondrial DNA lacking the heavy-strand promoter region"
2525:
2125:
1563:
and the major part of the protein is exposed to the periplasmic or to the mitochondrial
3209:
3184:
2455:
2430:
2362:
2337:
2251:
2226:
1977:
1952:
1785:
1769:
1556:
1496:
1492:
2721:
2696:
2678:
2653:
2089:
2064:
1673:
A wide range of symptoms have been found in patients with pathogenic mutations in the
679:
674:
669:
664:
659:
654:
649:
644:
639:
623:
618:
613:
608:
603:
598:
593:
588:
572:
567:
562:
557:
552:
4093:
4083:
3302:
3254:
3227:
2977:
2942:
2080:
2036:
2000:
1953:"Integration of cardiac proteome biology and medicine by a specialized knowledgebase"
1937:
1757:
1741:
1717:
1709:
1608:
1147:
1115:
539:
3175:
3130:
3058:
2842:
2644:
2415:
2304:
2176:
1256:
1079:
1029:
is one of the three cytochrome c oxidase subunit mitochondrial genes (orange boxes).
3935:
3910:
3568:
3447:
3360:
2933:
2888:
2549:
1821:
1809:
1765:
1725:
1678:
1627:
1600:
1589:
1548:
1488:
1454:
1302:
1181:
354:
179:
142:
2288:
1968:
1159:
1268:
1135:
1091:
166:
2751:
2652:
Moraes CT, Andreetta F, Bonilla E, Shanske S, DiMauro S, Schon EA (March 1991).
1906:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1888:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1817:
1697:
1693:
1484:
1476:
1427:
2947:
Proceedings of the
National Academy of Sciences of the United States of America
437:
3687:
3349:
3079:
2496:
1611:
1560:
1504:
276:
196:
146:
2712:
1748:
gene in patients have shown clinical manifestations such as progressive gait
3618:
2788:
2575:
2558:
2353:
2318:
2063:
García-Horsman JA, Barquera B, Rumbley J, Ma J, Gennis RB (September 1994).
1733:
1635:
1622:
affecting several tissues and organs. Other
Clinical Manifestations include
1567:, respectively. MT-CO2 provides the substrate-binding site and contains the
1508:
1450:
1359:
709:
497:
375:
320:
307:
242:
229:
154:
3263:
3244:
3218:
3167:
3122:
3087:
2504:
2464:
2407:
2371:
2296:
2260:
1986:
3050:
3021:
2986:
2967:
2925:
2880:
2834:
2796:
2759:
2730:
2687:
2669:
2636:
2606:
2584:
2242:
2168:
2133:
2098:
2044:
1119:
1005:
1000:
3764:
3638:
3271:
2697:"Nucleotide sequence of human mitochondrial cytochrome c oxidase II cDNA"
2541:
2208:
2190:
1813:
1781:
1737:
1615:
1500:
1263:
1086:
989:
854:
835:
3924:
3919:
3839:
3228:"Major genomic mitochondrial lineages delineate early human expansions"
2994:
Ruvolo M, Zehr S, von Dornum M, Pan D, Chang B, Lin J (November 1993).
2628:
2160:
1689:
1438:
1355:
1103:
1098:
821:
776:
87:
17:
4029:
4024:
3994:
3989:
3869:
3849:
3844:
3834:
3829:
3824:
3819:
3159:
2917:
2872:
2826:
2533:
2399:
2112:
Capaldi RA (1990). "Structure and function of cytochrome c oxidase".
1824:
in MT-CO2, including glutamate 129, aspartate 132, and glutamate 19.
1793:
1749:
1721:
1604:
1536:
1462:
1458:
1395:
1391:
1334:
1213:
973:
731:
3226:
Maca-Meyer N, González AM, Larruga JM, Flores C, Cabrera VM (2003).
2941:
Horai S, Hayasaka K, Kondo R, Tsugane K, Takahata N (January 1995).
2557:
Bodenteich A, Mitchell LG, Polymeropoulos MH, Merril CR (May 1992).
1042:
3200:
2446:
1547:. MT-CO2 plays an essential role in the transfer of electrons from
4049:
4044:
4034:
4019:
4014:
4009:
4004:
3999:
3984:
3979:
3974:
3969:
3964:
3959:
3954:
3949:
3944:
3740:
3727:
3113:
3096:
1540:
3042:
1936:
This article incorporates text from this source, which is in the
694:
690:
1744:
mutation (7587T>C) which altered the initiation codon of the
1363:
1296:
1251:
1175:
1130:
1074:
134:
3275:
27:
Enzyme of the respiratory chain encoded by a mitochondrial gene
2338:"Isolated cytochrome c oxidase deficiency as a cause of MELAS"
2025:
Biochimica et
Biophysica Acta (BBA) - Reviews on Bioenergetics
670:
positive regulation of hydrogen peroxide biosynthetic process
30:"COX2" redirects here. For the cyclooxygenase isoenzyme, see
1666:, which may be caused by an abnormality or deficiency of
1571:, probably the primary acceptor in cytochrome c oxidase.
1716:(7896G>A) of the gene resulted in phenotypes such as
1559:. It contains two adjacent transmembrane regions in its
660:
mitochondrial electron transport, cytochrome c to oxygen
344:
2996:"Mitochondrial COII sequences and modern human origins"
2559:"Dinucleotide repeat in the human mitochondrial D-loop"
2005:
Cardiac
Organellar Protein Atlas Knowledgebase (COPaKB)
2695:
Power MD, Kiefer MC, Barr PJ, Reeves R (August 1989).
2065:"The superfamily of heme-copper respiratory oxidases"
1595:
deficiency, a deficiency in an enzyme complex of the
1036:
Cytochrome c oxidase subunit II, transmembrane domain
509:
3933:
3908:
3878:
3858:
3808:
3799:
3753:
3716:
3684:
3652:
3600:
3591:
3547:
3515:
3488:
3466:
3429:
3420:
3397:
3369:
3346:
3319:
3310:
2740:
Cold Spring Harbor
Symposia on Quantitative Biology
1927:"Entrez Gene: COX2 cytochrome c oxidase subunit II"
1333:
1313:
1295:
1290:
1274:
1262:
1250:
1242:
1237:
1233:
Cytochrome C oxidase subunit II, periplasmic domain
1232:
1212:
1192:
1174:
1169:
1153:
1141:
1129:
1109:
1097:
1085:
1073:
1065:
1060:
1035:
934:
915:
891:
872:
452:
dentate gyrus of hippocampal formation granule cell
1862:
1860:
1858:
1841:
1839:
1837:
1426:gene produces a 25.6 kDa protein composed of 227
291:
213:
1796:have also been associated with mutations in the
1422:at position 12 and it spans 683 base pairs. The
3183:Finnilä S, Lehtonen MS, Majamaa K (June 2001).
1812:by the utilization of a lysine ring around the
1483:. The enzyme complex consists of 3-4 subunits (
1366:. Cytochrome c oxidase subunit II, abbreviated
680:positive regulation of ATP biosynthetic process
2227:"UniProt: the universal protein knowledgebase"
1867:GRCm38: Ensembl release 89: ENSMUSG00000064354
3287:
2058:
2056:
2054:
2018:
2016:
2014:
8:
1846:GRCh38: Ensembl release 89: ENSG00000198712
4080:United States National Library of Medicine
3805:
3775:Mitochondrial permeability transition pore
3757:
3597:
3426:
3316:
3294:
3280:
3272:
1287:
1166:
1041:
705:
675:positive regulation of necrotic cell death
619:mitochondrial respiratory chain complex IV
535:
332:
254:
174:
76:
3253:
3243:
3208:
3185:"Phylogenetic network for European mtDNA"
3112:
3011:
2976:
2966:
2720:
2677:
2574:
2454:
2361:
2250:
2149:Journal of Bioenergetics and Biomembranes
2088:
1976:
4078:This article incorporates text from the
3770:Mitochondrial membrane transport protein
1921:
1919:
1917:
1915:
1441:) (Complex IV), an oligomeric enzymatic
1025:gene in the human mitochondrial genome.
1016:
665:ATP synthesis coupled electron transport
1833:
1523:gene encodes for the second subunit of
3529:Cholesterol side-chain cleavage enzyme
1229:
1032:
36:
3013:10.1093/oxfordjournals.molbev.a040068
2319:"Mitochondrial complex IV deficiency"
1607:. The deficiency is characterized by
296:
280:
275:
218:
200:
195:
7:
1430:. MT-CO2 is a subunit of the enzyme
3443:Coenzyme Q – cytochrome c reductase
2126:10.1146/annurev.bi.59.070190.003033
1580:Mitochondrial complex IV deficiency
3629:Oxoglutarate dehydrogenase complex
3564:Glycerol-3-phosphate dehydrogenase
3189:American Journal of Human Genetics
2435:American Journal of Human Genetics
931:
912:
888:
869:
845:
826:
800:
781:
755:
736:
514:
432:
370:
349:
25:
3574:Carnitine palmitoyltransferase II
1808:MT-CO2 is known to interact with
1527:(complex IV), a component of the
3698:Carbamoyl phosphate synthetase I
3338:Long-chain-fatty-acid—CoA ligase
3333:Carnitine palmitoyltransferase I
2207: This article incorporates
2202:
2081:10.1128/jb.176.18.5587-5600.1994
2001:"Cytochrome c oxidase subunit 2"
1931:
1712:. Furthermore, a patient with a
1599:that catalyzes the oxidation of
1551:to the bimetallic center of the
267:
187:
3559:Glutamate aspartate transporter
3000:Molecular Biology and Evolution
2237:(D1): D158–D169. January 2017.
1597:mitochondrial respiratory chain
1529:mitochondrial respiratory chain
1493:binuclear copper A center (CuA)
1447:mitochondrial respiratory chain
3676:Pyruvate dehydrogenase complex
3634:Succinyl coenzyme A synthetase
2658:Molecular and Cellular Biology
1588:have been associated with the
1386:. It is also one of the three
1362:that is encoded by the MT-CO2
655:proton transmembrane transport
599:integral component of membrane
498:More reference expression data
406:right hemisphere of cerebellum
1:
2289:10.1136/jmedgenet-2014-102914
2114:Annual Review of Biochemistry
1969:10.1161/CIRCRESAHA.113.301151
1291:Available protein structures:
1170:Available protein structures:
573:cytochrome-c oxidase activity
418:muscle layer of sigmoid colon
3480:Dihydroorotate dehydrogenase
2037:10.1016/0304-4173(83)90003-4
1470:mitochondrial inner membrane
1449:involved in the transfer of
624:mitochondrial inner membrane
589:respiratory chain complex IV
3534:Steroid 11-beta-hydroxylase
2752:10.1101/sqb.1986.051.01.013
2342:Journal of Medical Genetics
2277:Journal of Medical Genetics
1624:hypertrophic cardiomyopathy
1382:, is the second subunit of
4131:
3708:N-Acetylglutamate synthase
3703:Ornithine transcarbamylase
3507:Glycerol phosphate shuttle
3373:monoamine neurotransmitter
1499:is located in a conserved
1390:(mtDNA) encoded subunits (
386:mucosa of transverse colon
29:
4100:Human mitochondrial genes
4062:
3760:
3736:
3433:oxidative phosphorylation
3080:10.3109/10428199909093740
2497:10.1016/j.tig.2006.04.001
1902:"Mouse PubMed Reference:"
1884:"Human PubMed Reference:"
1569:binuclear copper A center
1557:binuclear copper A center
1286:
1165:
1040:
1004:
999:
995:
988:
972:
953:
938:
919:
908:
895:
876:
865:
852:
848:
833:
829:
820:
807:
803:
788:
784:
775:
762:
758:
743:
739:
730:
715:
708:
704:
688:
538:
534:
522:
517:
508:
495:
444:
435:
382:
373:
343:
335:
331:
314:
301:
287:
282:Mitochondrial DNA (mouse)
266:
257:
253:
236:
223:
209:
203:Mitochondrial DNA (human)
186:
177:
173:
128:
125:
115:
108:
103:
84:
79:
62:
57:
52:
48:
44:
39:
3624:Isocitrate dehydrogenase
3502:Malate-aspartate shuttle
2563:Human Molecular Genetics
1648:developmental disability
1507:positions and conserved
640:electron transport chain
3671:Glutamate dehydrogenase
3458:Succinate dehydrogenase
3068:Leukemia & Lymphoma
2789:10.1126/science.3764430
2354:10.1136/jmg.2007.052076
2069:Journal of Bacteriology
1662:is also known to cause
1414:gene is located on the
1352:Cytochrome c oxidase II
568:oxidoreductase activity
4115:Transmembrane proteins
4067:mitochondrial diseases
3666:Aspartate transaminase
3323:fatty acid degradation
3245:10.1186/1471-2156-2-13
2713:10.1093/nar/17.16.6734
2701:Nucleic Acids Research
2231:Nucleic Acids Research
1762:pigmentary retinopathy
1614:ranging from isolated
1400:respiratory complex IV
1030:
3780:Mitochondrial carrier
3656:anaplerotic reactions
3492:mitochondrial shuttle
3470:pyrimidine metabolism
2968:10.1073/pnas.92.2.532
2670:10.1128/MCB.11.3.1631
2576:10.1093/hmg/1.2.140-a
1575:Clinical significance
1461:. In eukaryotes this
1020:
966:Chr M: 0.01 – 0.01 Mb
959:Chr M: 0.01 – 0.01 Mb
614:extracellular exosome
3787:Translocator protein
3644:Malate dehydrogenase
3539:Aldosterone synthase
2211:available under the
1957:Circulation Research
1754:cognitive impairment
1702:exercise intolerance
1644:exercise intolerance
1545:cytochrome c oxidase
1525:cytochrome c oxidase
1503:loop at 196 and 200
1432:Cytochrome c oxidase
1384:cytochrome c oxidase
1049:cytochrome c oxidase
80:List of PDB id codes
53:Available structures
3399:Intermembrane space
3152:2000Natur.408..708I
2959:1995PNAS...92..532H
2910:1981Natur.290..465M
2865:1981Natur.290..457A
2819:1985Natur.314..592C
2781:1986Sci...234..614C
2526:1979Natur.282..189B
2388:Annals of Neurology
2243:10.1093/nar/gkw1099
1620:multisystem disease
1565:intermembrane space
1553:catalytic subunit 1
1531:that catalyzes the
1479:it is found in the
4082:, which is in the
3754:Other/to be sorted
3719:alcohol metabolism
3579:Uncoupling protein
3453:NADH dehydrogenase
2629:10.1007/bf00206061
2485:Trends in Genetics
2161:10.1007/bf00762853
1768:, and mild distal-
1730:skin abnormalities
1668:cytochrome oxidase
1656:mental retardation
1468:is located in the
1055:indicated by blue.
1031:
810:ENSMUSG00000064354
633:Biological process
582:Cellular component
563:copper ion binding
546:Molecular function
410:hippocampus proper
398:right frontal lobe
4074:
4073:
4058:
4057:
3801:Mitochondrial DNA
3795:
3794:
3749:
3748:
3604:citric acid cycle
3587:
3586:
3393:
3392:
3385:Monoamine oxidase
1714:nonsense mutation
1706:mental impairment
1686:deletion mutation
1652:motor development
1632:liver dysfunction
1555:by utilizing its
1420:mitochondrial DNA
1388:mitochondrial DNA
1349:
1348:
1345:
1344:
1340:structure summary
1228:
1227:
1224:
1223:
1219:structure summary
1015:
1014:
1011:
1010:
984:
983:
949:
948:
928:
927:
904:
903:
885:
884:
861:
860:
842:
841:
816:
815:
797:
796:
771:
770:
752:
751:
700:
699:
558:metal ion binding
530:
529:
526:
525:
504:
503:
491:
490:
429:
428:
402:nucleus accumbens
327:
326:
249:
248:
99:
98:
95:
94:
63:Ortholog search:
16:(Redirected from
4122:
4110:Protein families
3938:
3913:
3883:
3863:
3813:
3806:
3758:
3721:
3691:
3659:
3614:Citrate synthase
3607:
3598:
3552:
3522:
3495:
3473:
3436:
3427:
3407:Adenylate kinase
3378:
3354:
3326:
3317:
3296:
3289:
3282:
3273:
3267:
3257:
3247:
3222:
3212:
3179:
3160:10.1038/35047064
3146:(6813): 708–13.
3134:
3116:
3091:
3062:
3025:
3015:
2990:
2980:
2970:
2937:
2918:10.1038/290465a0
2904:(5806): 465–70.
2892:
2873:10.1038/290457a0
2859:(5806): 457–65.
2846:
2827:10.1038/314592a0
2800:
2763:
2734:
2724:
2691:
2681:
2648:
2610:
2588:
2578:
2553:
2534:10.1038/282189a0
2520:(5735): 189–94.
2508:
2469:
2468:
2458:
2426:
2420:
2419:
2400:10.1002/ana.1141
2382:
2376:
2375:
2365:
2333:
2327:
2326:
2315:
2309:
2308:
2271:
2265:
2264:
2254:
2223:
2217:
2206:
2200:
2198:
2197:
2187:
2181:
2180:
2144:
2138:
2137:
2109:
2103:
2102:
2092:
2075:(18): 5587–600.
2060:
2049:
2048:
2020:
2009:
2008:
1997:
1991:
1990:
1980:
1947:
1941:
1935:
1934:
1930:
1923:
1910:
1909:
1898:
1892:
1891:
1880:
1874:
1864:
1853:
1843:
1764:, a decrease in
1605:molecular oxygen
1288:
1230:
1167:
1045:
1033:
1021:Location of the
997:
996:
968:
961:
944:
932:
923:
913:
909:RefSeq (protein)
899:
889:
880:
870:
846:
827:
801:
782:
756:
737:
706:
645:response to cold
536:
515:
500:
448:ventricular zone
440:
438:Top expressed in
433:
414:substantia nigra
378:
376:Top expressed in
371:
350:
333:
323:
310:
299:
283:
271:
255:
245:
232:
221:
205:
191:
175:
169:
167:COX2 - orthologs
120:
113:
90:
77:
71:
50:
49:
37:
32:Cyclooxygenase-2
21:
4130:
4129:
4125:
4124:
4123:
4121:
4120:
4119:
4105:Protein domains
4090:
4089:
4075:
4070:
4054:
3934:
3929:
3909:
3904:
3879:
3874:
3859:
3854:
3809:
3791:
3745:
3732:
3717:
3712:
3685:
3680:
3653:
3648:
3601:
3583:
3548:
3543:
3519:steroidogenesis
3516:
3511:
3489:
3484:
3467:
3462:
3430:
3416:
3412:Creatine kinase
3389:
3375:
3370:
3365:
3347:
3342:
3320:
3306:
3300:
3270:
3225:
3182:
3137:
3101:Nature Genetics
3094:
3065:
3031:Nature Genetics
3028:
2993:
2940:
2895:
2849:
2813:(6012): 592–7.
2803:
2775:(4776): 614–8.
2766:
2737:
2694:
2651:
2613:
2601:(13): 3718–25.
2595:Cancer Research
2591:
2556:
2511:
2482:
2478:
2476:Further reading
2473:
2472:
2428:
2427:
2423:
2384:
2383:
2379:
2335:
2334:
2330:
2323:www.uniprot.org
2317:
2316:
2312:
2273:
2272:
2268:
2225:
2224:
2220:
2195:
2193:
2189:
2188:
2184:
2146:
2145:
2141:
2111:
2110:
2106:
2062:
2061:
2052:
2022:
2021:
2012:
1999:
1998:
1994:
1949:
1948:
1944:
1932:
1925:
1924:
1913:
1900:
1899:
1895:
1882:
1881:
1877:
1865:
1856:
1844:
1835:
1830:
1806:
1790:lactic acidosis
1778:
1664:Leigh's disease
1658:. Mutations of
1640:muscle weakness
1582:
1577:
1517:
1481:plasma membrane
1410:In humans, the
1408:
1143:OPM superfamily
1056:
1006:View/Edit Mouse
1001:View/Edit Human
964:
957:
954:Location (UCSC)
940:
921:
897:
878:
791:ENSG00000198712
684:
628:
577:
553:protein binding
496:
487:
482:
480:proximal tubule
478:
474:
470:
466:
462:
458:
454:
450:
436:
425:
420:
416:
412:
408:
404:
400:
396:
394:caudate nucleus
392:
388:
374:
318:
305:
297:
281:
258:Gene location (
240:
227:
219:
201:
178:Gene location (
129:
116:
109:
86:
64:
35:
28:
23:
22:
15:
12:
11:
5:
4128:
4126:
4118:
4117:
4112:
4107:
4102:
4092:
4091:
4072:
4071:
4063:
4060:
4059:
4056:
4055:
4053:
4052:
4047:
4042:
4037:
4032:
4027:
4022:
4017:
4012:
4007:
4002:
3997:
3992:
3987:
3982:
3977:
3972:
3967:
3962:
3957:
3952:
3947:
3941:
3939:
3931:
3930:
3928:
3927:
3922:
3916:
3914:
3906:
3905:
3903:
3902:
3897:
3892:
3886:
3884:
3876:
3875:
3873:
3872:
3866:
3864:
3856:
3855:
3853:
3852:
3847:
3842:
3837:
3832:
3827:
3822:
3816:
3814:
3803:
3797:
3796:
3793:
3792:
3790:
3789:
3784:
3783:
3782:
3777:
3767:
3761:
3755:
3751:
3750:
3747:
3746:
3744:
3743:
3737:
3734:
3733:
3731:
3730:
3724:
3722:
3714:
3713:
3711:
3710:
3705:
3700:
3694:
3692:
3682:
3681:
3679:
3678:
3673:
3668:
3662:
3660:
3650:
3649:
3647:
3646:
3641:
3636:
3631:
3626:
3621:
3616:
3610:
3608:
3595:
3589:
3588:
3585:
3584:
3582:
3581:
3576:
3571:
3566:
3561:
3555:
3553:
3545:
3544:
3542:
3541:
3536:
3531:
3525:
3523:
3513:
3512:
3510:
3509:
3504:
3498:
3496:
3486:
3485:
3483:
3482:
3476:
3474:
3464:
3463:
3461:
3460:
3455:
3450:
3445:
3439:
3437:
3424:
3422:Inner membrane
3418:
3417:
3415:
3414:
3409:
3403:
3401:
3395:
3394:
3391:
3390:
3388:
3387:
3381:
3379:
3367:
3366:
3364:
3363:
3357:
3355:
3344:
3343:
3341:
3340:
3335:
3329:
3327:
3314:
3312:Outer membrane
3308:
3307:
3301:
3299:
3298:
3291:
3284:
3276:
3269:
3268:
3223:
3201:10.1086/320591
3195:(6): 1475–84.
3180:
3135:
3092:
3074:(1–2): 181–6.
3063:
3026:
3006:(6): 1115–35.
2991:
2938:
2893:
2847:
2801:
2764:
2735:
2692:
2649:
2617:Human Genetics
2611:
2589:
2554:
2509:
2479:
2477:
2474:
2471:
2470:
2447:10.1086/302361
2421:
2377:
2328:
2310:
2266:
2218:
2182:
2139:
2104:
2050:
2010:
1992:
1963:(9): 1043–53.
1942:
1911:
1893:
1875:
1854:
1832:
1831:
1829:
1826:
1805:
1802:
1786:encephalopathy
1777:
1774:
1770:muscle wasting
1704:, progressive
1684:deficiency. A
1677:gene with the
1581:
1578:
1576:
1573:
1516:
1513:
1487:) to up to 13
1407:
1404:
1347:
1346:
1343:
1342:
1337:
1331:
1330:
1317:
1311:
1310:
1300:
1293:
1292:
1284:
1283:
1278:
1272:
1271:
1266:
1260:
1259:
1254:
1248:
1247:
1244:
1240:
1239:
1235:
1234:
1226:
1225:
1222:
1221:
1216:
1210:
1209:
1196:
1190:
1189:
1179:
1172:
1171:
1163:
1162:
1157:
1151:
1150:
1145:
1139:
1138:
1133:
1127:
1126:
1113:
1107:
1106:
1101:
1095:
1094:
1089:
1083:
1082:
1077:
1071:
1070:
1067:
1063:
1062:
1058:
1057:
1046:
1038:
1037:
1013:
1012:
1009:
1008:
1003:
993:
992:
986:
985:
982:
981:
979:
977:
970:
969:
962:
955:
951:
950:
947:
946:
936:
935:
929:
926:
925:
917:
916:
910:
906:
905:
902:
901:
893:
892:
886:
883:
882:
874:
873:
867:
863:
862:
859:
858:
850:
849:
843:
840:
839:
831:
830:
824:
818:
817:
814:
813:
805:
804:
798:
795:
794:
786:
785:
779:
773:
772:
769:
768:
760:
759:
753:
750:
749:
741:
740:
734:
728:
727:
722:
717:
713:
712:
702:
701:
698:
697:
686:
685:
683:
682:
677:
672:
667:
662:
657:
652:
647:
642:
636:
634:
630:
629:
627:
626:
621:
616:
611:
606:
601:
596:
591:
585:
583:
579:
578:
576:
575:
570:
565:
560:
555:
549:
547:
543:
542:
532:
531:
528:
527:
524:
523:
520:
519:
512:
506:
505:
502:
501:
493:
492:
489:
488:
486:
485:
481:
477:
473:
469:
465:
461:
457:
453:
449:
445:
442:
441:
430:
427:
426:
424:
423:
419:
415:
411:
407:
403:
399:
395:
391:
387:
383:
380:
379:
367:
366:
358:
347:
341:
340:
337:RNA expression
329:
328:
325:
324:
316:
312:
311:
303:
300:
295:
289:
288:
285:
284:
279:
273:
272:
264:
263:
251:
250:
247:
246:
238:
234:
233:
225:
222:
217:
211:
210:
207:
206:
199:
193:
192:
184:
183:
171:
170:
127:
123:
122:
114:
106:
105:
101:
100:
97:
96:
93:
92:
82:
81:
73:
72:
61:
55:
54:
46:
45:
42:
41:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
4127:
4116:
4113:
4111:
4108:
4106:
4103:
4101:
4098:
4097:
4095:
4088:
4087:
4085:
4084:public domain
4081:
4069:
4068:
4061:
4051:
4048:
4046:
4043:
4041:
4038:
4036:
4033:
4031:
4028:
4026:
4023:
4021:
4018:
4016:
4013:
4011:
4008:
4006:
4003:
4001:
3998:
3996:
3993:
3991:
3988:
3986:
3983:
3981:
3978:
3976:
3973:
3971:
3968:
3966:
3963:
3961:
3958:
3956:
3953:
3951:
3948:
3946:
3943:
3942:
3940:
3937:
3932:
3926:
3923:
3921:
3918:
3917:
3915:
3912:
3907:
3901:
3898:
3896:
3893:
3891:
3888:
3887:
3885:
3882:
3877:
3871:
3868:
3867:
3865:
3862:
3857:
3851:
3848:
3846:
3843:
3841:
3838:
3836:
3833:
3831:
3828:
3826:
3823:
3821:
3818:
3817:
3815:
3812:
3807:
3804:
3802:
3798:
3788:
3785:
3781:
3778:
3776:
3773:
3772:
3771:
3768:
3766:
3763:
3762:
3759:
3756:
3752:
3742:
3739:
3738:
3735:
3729:
3726:
3725:
3723:
3720:
3715:
3709:
3706:
3704:
3701:
3699:
3696:
3695:
3693:
3690:
3689:
3683:
3677:
3674:
3672:
3669:
3667:
3664:
3663:
3661:
3658:
3657:
3651:
3645:
3642:
3640:
3637:
3635:
3632:
3630:
3627:
3625:
3622:
3620:
3617:
3615:
3612:
3611:
3609:
3606:
3605:
3599:
3596:
3594:
3590:
3580:
3577:
3575:
3572:
3570:
3567:
3565:
3562:
3560:
3557:
3556:
3554:
3551:
3546:
3540:
3537:
3535:
3532:
3530:
3527:
3526:
3524:
3521:
3520:
3514:
3508:
3505:
3503:
3500:
3499:
3497:
3494:
3493:
3487:
3481:
3478:
3477:
3475:
3472:
3471:
3465:
3459:
3456:
3454:
3451:
3449:
3446:
3444:
3441:
3440:
3438:
3435:
3434:
3428:
3425:
3423:
3419:
3413:
3410:
3408:
3405:
3404:
3402:
3400:
3396:
3386:
3383:
3382:
3380:
3377:
3374:
3368:
3362:
3359:
3358:
3356:
3353:
3351:
3345:
3339:
3336:
3334:
3331:
3330:
3328:
3325:
3324:
3318:
3315:
3313:
3309:
3304:
3303:Mitochondrial
3297:
3292:
3290:
3285:
3283:
3278:
3277:
3274:
3265:
3261:
3256:
3251:
3246:
3241:
3237:
3233:
3229:
3224:
3220:
3216:
3211:
3206:
3202:
3198:
3194:
3190:
3186:
3181:
3177:
3173:
3169:
3165:
3161:
3157:
3153:
3149:
3145:
3141:
3136:
3132:
3128:
3124:
3120:
3115:
3114:10.1038/13779
3110:
3106:
3102:
3098:
3093:
3089:
3085:
3081:
3077:
3073:
3069:
3064:
3060:
3056:
3052:
3048:
3044:
3040:
3036:
3032:
3027:
3023:
3019:
3014:
3009:
3005:
3001:
2997:
2992:
2988:
2984:
2979:
2974:
2969:
2964:
2960:
2956:
2952:
2948:
2944:
2939:
2935:
2931:
2927:
2923:
2919:
2915:
2911:
2907:
2903:
2899:
2894:
2890:
2886:
2882:
2878:
2874:
2870:
2866:
2862:
2858:
2854:
2848:
2844:
2840:
2836:
2832:
2828:
2824:
2820:
2816:
2812:
2808:
2802:
2798:
2794:
2790:
2786:
2782:
2778:
2774:
2770:
2765:
2761:
2757:
2753:
2749:
2746:(1): 103–14.
2745:
2741:
2736:
2732:
2728:
2723:
2718:
2714:
2710:
2706:
2702:
2698:
2693:
2689:
2685:
2680:
2675:
2671:
2667:
2664:(3): 1631–7.
2663:
2659:
2655:
2650:
2646:
2642:
2638:
2634:
2630:
2626:
2623:(2): 139–45.
2622:
2618:
2612:
2608:
2604:
2600:
2596:
2590:
2586:
2582:
2577:
2572:
2568:
2564:
2560:
2555:
2551:
2547:
2543:
2539:
2535:
2531:
2527:
2523:
2519:
2515:
2510:
2506:
2502:
2498:
2494:
2491:(6): 339–45.
2490:
2486:
2481:
2480:
2475:
2466:
2462:
2457:
2452:
2448:
2444:
2441:(5): 1330–9.
2440:
2436:
2432:
2425:
2422:
2417:
2413:
2409:
2405:
2401:
2397:
2394:(3): 409–13.
2393:
2389:
2381:
2378:
2373:
2369:
2364:
2359:
2355:
2351:
2348:(2): 117–21.
2347:
2343:
2339:
2332:
2329:
2324:
2320:
2314:
2311:
2306:
2302:
2298:
2294:
2290:
2286:
2282:
2278:
2270:
2267:
2262:
2258:
2253:
2248:
2244:
2240:
2236:
2232:
2228:
2222:
2219:
2216:
2214:
2210:
2205:
2192:
2186:
2183:
2178:
2174:
2170:
2166:
2162:
2158:
2155:(2): 115–20.
2154:
2150:
2143:
2140:
2135:
2131:
2127:
2123:
2119:
2115:
2108:
2105:
2100:
2096:
2091:
2086:
2082:
2078:
2074:
2070:
2066:
2059:
2057:
2055:
2051:
2046:
2042:
2038:
2034:
2031:(2): 135–48.
2030:
2026:
2019:
2017:
2015:
2011:
2006:
2002:
1996:
1993:
1988:
1984:
1979:
1974:
1970:
1966:
1962:
1958:
1954:
1946:
1943:
1939:
1938:public domain
1928:
1922:
1920:
1918:
1916:
1912:
1907:
1903:
1897:
1894:
1889:
1885:
1879:
1876:
1872:
1868:
1863:
1861:
1859:
1855:
1851:
1847:
1842:
1840:
1838:
1834:
1827:
1825:
1823:
1819:
1815:
1811:
1803:
1801:
1799:
1795:
1791:
1787:
1783:
1775:
1773:
1771:
1767:
1763:
1759:
1758:optic atrophy
1755:
1751:
1747:
1743:
1742:heteroplasmic
1739:
1736:, and normal
1735:
1731:
1727:
1723:
1719:
1718:short stature
1715:
1711:
1707:
1703:
1699:
1695:
1691:
1687:
1683:
1680:
1679:mitochondrial
1676:
1671:
1669:
1665:
1661:
1657:
1653:
1649:
1645:
1641:
1637:
1633:
1629:
1625:
1621:
1617:
1613:
1610:
1609:heterogeneous
1606:
1602:
1598:
1594:
1591:
1590:mitochondrial
1587:
1579:
1574:
1572:
1570:
1566:
1562:
1558:
1554:
1550:
1546:
1542:
1538:
1534:
1530:
1526:
1522:
1514:
1512:
1510:
1506:
1502:
1498:
1494:
1490:
1486:
1482:
1478:
1475:
1471:
1467:
1464:
1460:
1456:
1452:
1448:
1444:
1440:
1437:
1433:
1429:
1425:
1421:
1417:
1413:
1405:
1403:
1401:
1397:
1393:
1389:
1385:
1381:
1377:
1373:
1369:
1365:
1361:
1357:
1353:
1341:
1338:
1336:
1332:
1329:
1325:
1321:
1318:
1316:
1312:
1308:
1304:
1301:
1298:
1294:
1289:
1285:
1282:
1279:
1277:
1273:
1270:
1267:
1265:
1261:
1258:
1255:
1253:
1249:
1245:
1241:
1236:
1231:
1220:
1217:
1215:
1211:
1208:
1204:
1200:
1197:
1195:
1191:
1187:
1183:
1180:
1177:
1173:
1168:
1164:
1161:
1158:
1156:
1152:
1149:
1146:
1144:
1140:
1137:
1134:
1132:
1128:
1125:
1121:
1117:
1114:
1112:
1108:
1105:
1102:
1100:
1096:
1093:
1090:
1088:
1084:
1081:
1078:
1076:
1072:
1068:
1064:
1059:
1054:
1050:
1044:
1039:
1034:
1028:
1024:
1019:
1007:
1002:
998:
994:
991:
987:
980:
978:
975:
971:
967:
963:
960:
956:
952:
945:
943:
937:
933:
930:
924:
918:
914:
911:
907:
900:
894:
890:
887:
881:
875:
871:
868:
866:RefSeq (mRNA)
864:
857:
856:
851:
847:
844:
838:
837:
832:
828:
825:
823:
819:
812:
811:
806:
802:
799:
793:
792:
787:
783:
780:
778:
774:
767:
766:
761:
757:
754:
748:
747:
742:
738:
735:
733:
729:
726:
723:
721:
718:
714:
711:
707:
703:
696:
692:
687:
681:
678:
676:
673:
671:
668:
666:
663:
661:
658:
656:
653:
651:
648:
646:
643:
641:
638:
637:
635:
632:
631:
625:
622:
620:
617:
615:
612:
610:
607:
605:
604:mitochondrion
602:
600:
597:
595:
592:
590:
587:
586:
584:
581:
580:
574:
571:
569:
566:
564:
561:
559:
556:
554:
551:
550:
548:
545:
544:
541:
540:Gene ontology
537:
533:
521:
516:
513:
511:
507:
499:
494:
483:
479:
475:
471:
467:
463:
459:
455:
451:
447:
446:
443:
439:
434:
431:
421:
417:
413:
409:
405:
401:
397:
393:
389:
385:
384:
381:
377:
372:
369:
368:
365:
363:
359:
357:
356:
352:
351:
348:
346:
342:
338:
334:
330:
322:
317:
313:
309:
304:
294:
290:
286:
278:
274:
270:
265:
261:
256:
252:
244:
239:
235:
231:
226:
216:
212:
208:
204:
198:
194:
190:
185:
181:
176:
172:
168:
164:
160:
156:
152:
148:
144:
140:
136:
132:
124:
119:
112:
107:
102:
91:
89:
83:
78:
75:
74:
70:
67:
60:
56:
51:
47:
43:
38:
33:
19:
4077:
4076:
4064:
3911:ATP synthase
3718:
3686:
3654:
3602:
3569:ATP synthase
3549:
3517:
3490:
3468:
3448:Cytochrome c
3431:
3371:
3361:Kynureninase
3348:
3321:
3235:
3232:BMC Genetics
3231:
3192:
3188:
3143:
3139:
3104:
3100:
3071:
3067:
3043:10.1038/3108
3037:(3): 291–3.
3034:
3030:
3003:
2999:
2953:(2): 532–6.
2950:
2946:
2901:
2897:
2856:
2852:
2810:
2806:
2772:
2768:
2743:
2739:
2707:(16): 6734.
2704:
2700:
2661:
2657:
2620:
2616:
2598:
2594:
2566:
2562:
2517:
2513:
2488:
2484:
2438:
2434:
2424:
2391:
2387:
2380:
2345:
2341:
2331:
2322:
2313:
2283:(3): 203–7.
2280:
2276:
2269:
2234:
2230:
2221:
2201:
2194:. Retrieved
2185:
2152:
2148:
2142:
2117:
2113:
2107:
2072:
2068:
2028:
2024:
2004:
1995:
1960:
1956:
1945:
1905:
1896:
1887:
1878:
1822:cytochrome c
1810:cytochrome c
1807:
1804:Interactions
1797:
1779:
1766:color vision
1756:, bilateral
1745:
1726:microcephaly
1708:, and short
1674:
1672:
1659:
1628:hepatomegaly
1601:cytochrome c
1585:
1584:Variants of
1583:
1549:cytochrome c
1520:
1518:
1489:polypeptides
1455:cytochrome c
1423:
1411:
1409:
1379:
1375:
1371:
1367:
1351:
1350:
1052:
1026:
1022:
939:
920:
896:
877:
853:
834:
808:
789:
763:
744:
724:
719:
476:right kidney
460:zone of skin
422:hypothalamus
360:
353:
126:External IDs
85:
3861:Complex III
1816:containing
1698:hemianopsia
1694:hemiparesis
1485:prokaryotes
1477:prokaryotes
1428:amino acids
1238:Identifiers
1155:OPM protein
1061:Identifiers
594:respirasome
104:Identifiers
4094:Categories
3881:Complex IV
3688:urea cycle
3376:metabolism
3352:metabolism
3350:tryptophan
3107:(2): 147.
2569:(2): 140.
2196:2018-08-07
2120:: 569–96.
1873:, May 2017
1852:, May 2017
1828:References
1740:. A novel
1682:Complex IV
1650:, delayed
1618:to severe
1612:phenotypes
1603:utilizing
1593:Complex IV
1561:N-terminus
1505:amino acid
1394:, MT-CO2,
1360:eukaryotes
1303:structures
1182:structures
1053:Subunit II
1047:Bacterial
364:(ortholog)
147:HomoloGene
4065:see also
3811:Complex I
3619:Aconitase
2213:CC BY 4.0
1818:heme edge
1780:Juvenile
1734:hypotonia
1732:, severe
1636:hypotonia
1533:reduction
1509:histidine
1451:electrons
1406:Structure
1269:IPR002429
1104:PDOC00075
1092:IPR011759
1051:complex.
942:NP_904331
710:Orthologs
650:lactation
456:esophagus
155:GeneCards
3765:Frataxin
3639:Fumarase
3305:proteins
3264:11553319
3219:11349229
3176:52850476
3168:11130070
3131:32212178
3123:10508508
3088:10194136
3059:19786796
2843:32964006
2645:28048453
2505:16678300
2465:10205264
2416:23891106
2408:11558799
2372:18245391
2305:43018915
2297:25604084
2261:27899622
2215:license.
2177:45975377
1987:23965338
1869:–
1848:–
1814:carboxyl
1782:myopathy
1738:reflexes
1692:, right
1616:myopathy
1515:Function
1501:cysteine
1320:RCSB PDB
1264:InterPro
1199:RCSB PDB
1087:InterPro
990:Wikidata
689:Sources:
609:membrane
484:duodenum
468:epiblast
3925:MT-ATP8
3920:MT-ATP6
3840:MT-ND4L
3210:1226134
3148:Bibcode
3051:9806551
3022:8277847
2987:7530363
2955:Bibcode
2934:4358928
2926:7219535
2906:Bibcode
2889:4355527
2881:7219534
2861:Bibcode
2835:3921850
2815:Bibcode
2797:3764430
2777:Bibcode
2769:Science
2760:3472707
2731:2550900
2688:1996112
2637:1757091
2607:1377597
2585:1301157
2550:4335828
2522:Bibcode
2456:1377869
2386:gene".
2363:3027970
2252:5210571
2169:8389744
2134:2165384
2099:8083153
2045:6307356
1978:4076475
1871:Ensembl
1850:Ensembl
1710:stature
1690:aphasia
1474:aerobic
1466:complex
1445:of the
1443:complex
1439:1.9.3.1
1356:protein
1281:cd13912
1257:PF00116
1099:PROSITE
1080:PF02790
1069:COX2_TM
822:UniProt
777:Ensembl
716:Species
695:QuickGO
472:jejunum
390:putamen
339:pattern
111:Aliases
4030:MT-TS2
4025:MT-TS1
3995:MT-TL2
3990:MT-TL1
3900:MT-CO3
3895:MT-CO2
3890:MT-CO1
3870:MT-CYB
3850:MT-ND6
3845:MT-ND5
3835:MT-ND4
3830:MT-ND3
3825:MT-ND2
3820:MT-ND1
3593:Matrix
3262:
3252:
3238:: 13.
3217:
3207:
3174:
3166:
3140:Nature
3129:
3121:
3086:
3057:
3049:
3020:
2985:
2975:
2932:
2924:
2898:Nature
2887:
2879:
2853:Nature
2841:
2833:
2807:Nature
2795:
2758:
2729:
2722:318375
2719:
2686:
2679:369459
2676:
2643:
2635:
2605:
2583:
2548:
2542:226894
2540:
2514:Nature
2503:
2463:
2453:
2414:
2406:
2370:
2360:
2303:
2295:
2259:
2249:
2175:
2167:
2132:
2097:
2090:196760
2087:
2043:
1985:
1975:
1800:gene.
1798:MT-CO2
1794:stroke
1792:, and
1776:Others
1750:ataxia
1746:MT-CO2
1722:weight
1720:, low
1675:MT-CO2
1660:MT-CO2
1586:MT-CO2
1537:oxygen
1521:MT-CO2
1495:. The
1463:enzyme
1459:oxygen
1424:MT-CO2
1412:MT-CO2
1396:MT-CO3
1392:MT-CO1
1380:MT-CO2
1335:PDBsum
1309:
1299:
1243:Symbol
1214:PDBsum
1188:
1178:
1124:SUPFAM
1066:Symbol
1027:MT-CO2
1023:MT-CO2
976:search
974:PubMed
855:P00405
836:P00403
732:Entrez
510:BioGPS
319:7,696
306:7,013
241:8,269
228:7,586
143:102503
135:516040
18:MT-CO2
4050:MT-TY
4045:MT-TW
4040:MT-TV
4035:MT-TT
4020:MT-TR
4015:MT-TQ
4010:MT-TP
4005:MT-TN
4000:MT-TM
3985:MT-TK
3980:MT-TI
3975:MT-TH
3970:MT-TG
3965:MT-TF
3960:MT-TE
3955:MT-TD
3950:MT-TC
3945:MT-TA
3741:PMPCB
3728:ALDH2
3550:other
3255:55343
3172:S2CID
3127:S2CID
3055:S2CID
2978:42775
2930:S2CID
2885:S2CID
2839:S2CID
2641:S2CID
2546:S2CID
2412:S2CID
2301:S2CID
2173:S2CID
1541:water
1472:; in
1453:from
1416:p arm
1398:) of
1378:, or
1368:COXII
1354:is a
1136:3.D.4
1120:SCOPe
1111:SCOP2
765:17709
725:Mouse
720:Human
691:Amigo
464:ovary
362:Mouse
355:Human
302:Start
260:Mouse
224:Start
180:Human
3936:tRNA
3260:PMID
3215:PMID
3164:PMID
3119:PMID
3084:PMID
3047:PMID
3018:PMID
2983:PMID
2922:PMID
2877:PMID
2831:PMID
2793:PMID
2756:PMID
2727:PMID
2684:PMID
2633:PMID
2603:PMID
2581:PMID
2538:PMID
2501:PMID
2461:PMID
2404:PMID
2368:PMID
2293:PMID
2257:PMID
2209:text
2165:PMID
2130:PMID
2095:PMID
2041:PMID
1983:PMID
1654:and
1630:and
1519:The
1376:COII
1372:COX2
1364:gene
1328:PDBj
1324:PDBe
1307:ECOD
1297:Pfam
1252:Pfam
1246:COX2
1207:PDBj
1203:PDBe
1186:ECOD
1176:Pfam
1160:1v55
1131:TCDB
1116:1occ
1075:Pfam
746:4513
345:Bgee
293:Band
277:Chr.
215:Band
197:Chr.
159:COX2
151:5017
131:OMIM
118:COX2
88:3VRJ
69:RCSB
66:PDBe
40:COX2
3250:PMC
3240:doi
3205:PMC
3197:doi
3156:doi
3144:408
3109:doi
3076:doi
3039:doi
3008:doi
2973:PMC
2963:doi
2914:doi
2902:290
2869:doi
2857:290
2823:doi
2811:314
2785:doi
2773:234
2748:doi
2717:PMC
2709:doi
2674:PMC
2666:doi
2625:doi
2571:doi
2530:doi
2518:282
2493:doi
2451:PMC
2443:doi
2396:doi
2358:PMC
2350:doi
2285:doi
2247:PMC
2239:doi
2157:doi
2122:doi
2085:PMC
2077:doi
2073:176
2033:doi
2029:726
1973:PMC
1965:doi
1961:113
1820:of
1539:to
1535:of
1497:CuA
1457:to
1418:of
1358:in
1315:PDB
1276:CDD
1194:PDB
922:n/a
898:n/a
879:n/a
518:n/a
315:End
298:n/a
237:End
220:n/a
163:OMA
139:MGI
59:PDB
4096::
3258:.
3248:.
3234:.
3230:.
3213:.
3203:.
3193:68
3191:.
3187:.
3170:.
3162:.
3154:.
3142:.
3125:.
3117:.
3105:23
3103:.
3099:.
3082:.
3072:33
3070:.
3053:.
3045:.
3035:20
3033:.
3016:.
3004:10
3002:.
2998:.
2981:.
2971:.
2961:.
2951:92
2949:.
2945:.
2928:.
2920:.
2912:.
2900:.
2883:.
2875:.
2867:.
2855:.
2837:.
2829:.
2821:.
2809:.
2791:.
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2771:.
2754:.
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2742:.
2725:.
2715:.
2705:17
2703:.
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2672:.
2662:11
2660:.
2656:.
2639:.
2631:.
2621:88
2619:.
2599:52
2597:.
2579:.
2565:.
2561:.
2544:.
2536:.
2528:.
2516:.
2499:.
2489:22
2487:.
2459:.
2449:.
2439:64
2437:.
2433:.
2410:.
2402:.
2392:50
2390:.
2366:.
2356:.
2346:45
2344:.
2340:.
2321:.
2299:.
2291:.
2281:52
2279:.
2255:.
2245:.
2235:45
2233:.
2229:.
2171:.
2163:.
2153:25
2151:.
2128:.
2118:59
2116:.
2093:.
2083:.
2071:.
2067:.
2053:^
2039:.
2027:.
2013:^
2003:.
1981:.
1971:.
1959:.
1955:.
1914:^
1904:.
1886:.
1857:^
1836:^
1788:,
1784:,
1772:.
1760:,
1752:,
1728:,
1724:,
1700:,
1696:,
1670:.
1646:,
1642:,
1638:,
1634:,
1626:,
1436:EC
1402:.
1374:,
1370:,
1326:;
1322:;
1305:/
1205:;
1201:;
1184:/
1122:/
1118:/
693:/
321:bp
308:bp
243:bp
230:bp
161:;
157::
153:;
149::
145:;
141::
137:;
133::
4086:.
3295:e
3288:t
3281:v
3266:.
3242::
3236:2
3221:.
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3158::
3150::
3133:.
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3090:.
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3061:.
3041::
3024:.
3010::
2989:.
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2957::
2936:.
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2762:.
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2690:.
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2647:.
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2609:.
2587:.
2573::
2567:1
2552:.
2532::
2524::
2507:.
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2467:.
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2418:.
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2325:.
2307:.
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2263:.
2241::
2199:.
2179:.
2159::
2136:.
2124::
2101:.
2079::
2047:.
2035::
2007:.
1989:.
1967::
1940:.
1929:.
1908:.
1890:.
1434:(
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262:)
182:)
165::
34:.
20:)
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