327:
304:
38:
201:
226:
578:
333:
232:
1401:
MYD88 seems to function similarly to mice, since the immunological phenotype of human cells deficient in MYD88 is similar to cells from MyD88 deficient mice. However, available evidence suggests that MYD88 is dispensable for human resistance to common viral infections and to all but a few
64:
1354:) sensing extracellular or phagocytosed pathogens, respectively. TLRs are integral membrane glycoproteins with typical semicircular-shaped extracellular parts containing leucine-rich repeats responsible for ligand binding, and Intracellular parts containing
1406:
bacterial infections, demonstrating a major difference between mouse and human immune responses. Mutation in MYD88 at position 265 leading to a change from leucine to proline have been identified in many human lymphomas including ABC subtype of
1980:"Inhibition of interleukin-1beta -induced NF-kappa B activation by calcium/calmodulin-dependent protein kinase kinase occurs through Akt activation associated with interleukin-1 receptor-associated kinase phosphorylation and uncoupling of MyD88"
1464:
Various single nucleotide polymorphisms (SNPs) of the MyD88 have been identified. and for some of them an association with susceptibility to various infectious diseases and to some autoimmune diseases like
1376:
is a dimeric protein responsible for expression of various inflammatory cytokines, chemokines and adhesion and costimulatory molecules, which in turn triggers acute inflammation and stimulation of adaptive
2902:"Human gingival CD14(+) fibroblasts primed with gamma interferon increase production of interleukin-8 in response to lipopolysaccharide through up-regulation of membrane CD14 and MyD88 mRNA expression"
3218:
2775:
Fitzgerald KA, Palsson-McDermott EM, Bowie AG, Jefferies CA, Mansell AS, Brady G, et al. (September 2001). "Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction".
1883:
Fitzgerald KA, Palsson-McDermott EM, Bowie AG, Jefferies CA, Mansell AS, Brady G, et al. (September 2001). "Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction".
2820:
Tauszig-Delamasure S, Bilak H, Capovilla M, Hoffmann JA, Imler JL (January 2002). "Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections".
2660:
Burns K, Clatworthy J, Martin L, Martinon F, Plumpton C, Maschera B, et al. (June 2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor".
2124:
Burns K, Clatworthy J, Martin L, Martinon F, Plumpton C, Maschera B, et al. (June 2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor".
2450:
Bonnert TP, Garka KE, Parnet P, Sonoda G, Testa JR, Sims JE (January 1997). "The cloning and characterization of human MyD88: a member of an IL-1 receptor related family".
1577:
Bonnert TP, Garka KE, Parnet P, Sonoda G, Testa JR, Sims JE (January 1997). "The cloning and characterization of human MyD88: a member of an IL-1 receptor related family".
3211:
340:
239:
3453:
1709:
2742:"Murine TOLL-like receptor 4 confers lipopolysaccharide responsiveness as determined by activation of NF kappa B and expression of the inducible cyclooxygenase"
2302:"Murine TOLL-like receptor 4 confers lipopolysaccharide responsiveness as determined by activation of NF kappa B and expression of the inducible cyclooxygenase"
3204:
2553:
Jaunin F, Burns K, Tschopp J, Martin TE, Fakan S (August 1998). "Ultrastructural distribution of the death-domain-containing MyD88 protein in HeLa cells".
2487:
Hardiman G, Jenkins NA, Copeland NG, Gilbert DJ, Garcia DK, Naylor SL, et al. (October 1997). "Genetic structure and chromosomal mapping of MyD88".
2169:"Transactivation by the p65 subunit of NF-kappaB in response to interleukin-1 (IL-1) involves MyD88, IL-1 receptor-associated kinase 1, TRAF-6, and Rac1"
3076:"Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells"
926:
133:, MYD88D, myeloid differentiation primary response 88, innate immune signal transduction adaptor, MYD88 innate immune signal transduction adaptor, IMD68
907:
162:
2429:
Hardiman G, Rock FL, Balasubramanian S, Kastelein RA, Bazan JF (December 1996). "Molecular characterization and modular analysis of human MyD88".
1263:. originally discovered in the laboratory of Dan A. Liebermann (Lord et al. Oncogene 1990) as a Myeloid differentiation primary response gene.
2945:"Identification of essential regions in the cytoplasmic tail of interleukin-1 receptor accessory protein critical for interleukin-1 signaling"
1685:
1545:
1291:
1527:
1412:
3663:
3446:
3254:
2516:
Muzio M, Ni J, Feng P, Dixit VM (November 1997). "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling".
2081:
Muzio M, Ni J, Feng P, Dixit VM (November 1997). "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling".
1295:
326:
3579:
3564:
3235:
1272:
1197:
1190:
303:
1271:
The MYD88 gene provides instructions for making a protein involved in signaling within immune cells. The MyD88 protein acts as an
3330:
1563:
1514:
1493:
3678:
3439:
3350:
1442:
1510:
225:
200:
61:
1408:
2584:"Pinocembrin protects hemorrhagic brain primarily by inhibiting toll-like receptor 4 and reducing M1 phenotype microglia"
1489:
3196:
1383:
is a group of proteins responsible for expression of type I interferons setting the so-called antiviral state of a cell.
1287:
142:
1424:
1275:, connecting proteins that receive signals from outside the cell to the proteins that relay signals inside the cell.
339:
238:
2341:
Netea MG, Wijmenga C, O'Neill LA (May 2012). "Genetic variation in Toll-like receptors and disease susceptibility".
3243:
2980:"Regulation of interleukin-1- and lipopolysaccharide-induced NF-kappaB activation by alternative splicing of MyD88"
332:
231:
2386:"The *1244 A>G polymorphism of MyD88 (rs7744) is closely associated with susceptibility to ulcerative colitis"
1355:
3190:
1365:, interact with adaptor protein MyD88. Another adaptor protein, which is activated by TLR3 and TLR4, is called
971:
150:
2216:
Chuang TH, Ulevitch RJ (May 2004). "Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors".
3673:
952:
3111:"Role of the MyD88 transduction signaling pathway in endothelial activation by antiphospholipid antibodies"
3668:
1314:
have been proved in all animals from insects to mammals. TLRs are located either on the cellular surface (
3569:
3533:
3528:
37:
3523:
3518:
3513:
3508:
3503:
3498:
3493:
3488:
3483:
3034:
2991:
2784:
2525:
2090:
2032:
1892:
1793:
1736:
214:
129:
3462:
1152:
1148:
1144:
1140:
1126:
1122:
1118:
1114:
1073:
1069:
1065:
1061:
1047:
1043:
1039:
1035:
2859:"The Fas-associated death domain protein suppresses activation of NF-kappa B by LPS and IL-1 beta"
2384:
Matsunaga K, Tahara T, Shiroeda H, Otsuka T, Nakamura M, Shimasaki T, et al. (January 2014).
3543:
3538:
3475:
3466:
3411:
2845:
2808:
2685:
2475:
2366:
2241:
2149:
1916:
1703:
1602:
1466:
1394:
activate both NF-κB and IRF3 through MyD88-dependent and TRIF-independent pathway, respectively.
1311:
1290:(PRR). In general, these receptors sense common patterns which are shared by various pathogens –
1283:
174:
1304:
are homologous to Toll receptors, which were first described in the onthogenesis of fruit flies
1173:
1130:
1094:
1051:
3167:
3132:
3097:
3062:
3009:
2966:
2931:
2888:
2837:
2800:
2763:
2728:
2677:
2648:
2627:"IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family"
2613:
2570:
2541:
2504:
2467:
2438:
2407:
2358:
2323:
2282:
2233:
2198:
2141:
2106:
2060:
2001:
1960:
1939:"IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family"
1908:
1860:
1819:
1762:
1691:
1681:
1653:
1594:
122:
54:
3157:
3122:
3087:
3052:
3042:
2999:
2956:
2921:
2913:
2878:
2870:
2829:
2792:
2753:
2718:
2710:
2669:
2638:
2603:
2595:
2562:
2533:
2496:
2459:
2397:
2350:
2313:
2272:
2225:
2188:
2180:
2133:
2098:
2050:
2040:
1991:
1950:
1900:
1850:
1809:
1801:
1752:
1744:
1643:
1633:
1586:
419:
350:
294:
249:
3431:
577:
170:
3231:
3146:"Toll-like receptor 3 mediates a more potent antiviral response than Toll-like receptor 4"
2261:"Toll-like receptor 3 mediates a more potent antiviral response than Toll-like receptor 4"
1279:
394:
3186:
3109:
Raschi E, Testoni C, Bosisio D, Borghi MO, Koike T, Mantovani A, et al. (May 2003).
2900:
Tamai R, Sakuta T, Matsushita K, Torii M, Takeuchi O, Akira S, et al. (March 2002).
3038:
2995:
2788:
2529:
2094:
2036:
1896:
1797:
1740:
3345:
3303:
3227:
2608:
2583:
1814:
1781:
1757:
1724:
1648:
1621:
3057:
3022:
3004:
2979:
2926:
2901:
2883:
2858:
2723:
2698:
2463:
2055:
2020:
1590:
841:
836:
831:
826:
821:
816:
811:
806:
801:
796:
791:
786:
781:
776:
771:
766:
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751:
746:
741:
736:
731:
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644:
639:
634:
629:
624:
619:
3657:
3264:
2193:
2184:
2168:
606:
2917:
2849:
2689:
2479:
2370:
2245:
2153:
1780:
Ngo VN, Young RM, Schmitz R, Jhavar S, Xiao W, Lim KH, et al. (February 2011).
1723:
von
Bernuth H, Picard C, Jin Z, Pankla R, Xiao H, Ku CL, et al. (August 2008).
1606:
2812:
2385:
1920:
1369:(TRIF). Subsequently, these proteins activate two important transcription factors:
412:
191:
154:
2537:
2102:
3023:"IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase"
2021:"IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase"
178:
3416:
3162:
3145:
3092:
3075:
2277:
2260:
1550:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1532:
National Center for
Biotechnology Information, U.S. National Library of Medicine
3127:
3110:
3027:
Proceedings of the
National Academy of Sciences of the United States of America
2714:
2025:
Proceedings of the
National Academy of Sciences of the United States of America
495:
2599:
1306:
311:
208:
158:
2643:
2626:
1955:
1938:
1695:
3325:
1748:
871:
832:
positive regulation of cytokine production involved in inflammatory response
555:
433:
378:
365:
277:
264:
166:
3171:
3136:
3101:
3074:
Medvedev AE, Lentschat A, Wahl LM, Golenbock DT, Vogel SN (November 2002).
3066:
3047:
3013:
2970:
2961:
2944:
2935:
2892:
2841:
2804:
2767:
2758:
2741:
2732:
2681:
2652:
2617:
2566:
2500:
2411:
2362:
2327:
2318:
2301:
2286:
2237:
2202:
2145:
2064:
2045:
2005:
1996:
1979:
1964:
1912:
1864:
1823:
1766:
1657:
2943:
Radons J, Gabler S, Wesche H, Korherr C, Hofmeister R, Falk W (May 2002).
2574:
2545:
2508:
2471:
2442:
2402:
2110:
1855:
1838:
1675:
1598:
1237:
1232:
3335:
3320:
1837:
Treon SP, Xu L, Yang G, Zhou Y, Liu X, Cao Y, et al. (August 2012).
1403:
1398:
1373:
1335:
1221:
1016:
997:
3144:
Doyle SE, O'Connell R, Vaidya SA, Chow EK, Yee K, Cheng G (April 2003).
2697:
Aliprantis AO, Yang RB, Weiss DS, Godowski P, Zychlinsky A (July 2000).
2259:
Doyle SE, O'Connell R, Vaidya SA, Chow EK, Yee K, Cheng G (April 2003).
1805:
2857:
Bannerman DD, Tupper JC, Kelly JD, Winn RK, Harlan JM (February 2002).
2167:
Jefferies C, Bowie A, Brady G, Cooke EL, Li X, O'Neill LA (July 2001).
1564:"Entrez Gene: MYD88 Myeloid differentiation primary response gene (88)"
1253:
983:
938:
827:
cellular response to oxidised low-density lipoprotein particle stimulus
99:
95:
91:
87:
83:
3637:
3627:
3612:
3393:
2874:
2796:
2673:
2137:
1904:
1205:
893:
2582:
Lan X, Han X, Li Q, Li Q, Gao Y, Cheng T, et al. (March 2017).
2354:
2699:"The apoptotic signaling pathway activated by Toll-like receptor-2"
2625:
Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z (July 1999).
2229:
1937:
Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z (July 1999).
1638:
1282:, the MyD88 plays a pivotal role in immune cell activation through
3642:
3632:
3602:
3597:
3592:
3587:
3380:
3375:
3370:
3365:
3360:
3355:
3313:
3308:
3283:
2833:
1452:
1437:
1432:
1315:
1839:"MYD88 L265P somatic mutation in Waldenström's macroglobulinemia"
1294:(PAMPs), or which are produced/released during cellular damage –
856:
852:
3622:
3607:
3559:
3398:
3388:
3278:
3273:
1447:
1391:
1387:
1380:
1366:
1362:
1351:
1347:
1343:
1339:
1331:
1327:
1323:
1319:
1301:
1260:
146:
22:
3435:
3200:
1725:"Pyogenic bacterial infections in humans with MyD88 deficiency"
586:
787:
positive regulation of NF-kappaB transcription factor activity
1310:, being responsible for dorso-ventral development. Hence,
742:
positive regulation of I-kappaB kinase/NF-kappaB signaling
2978:
Janssens S, Burns K, Tschopp J, Beyaert R (March 2002).
1782:"Oncogenically active MYD88 mutations in human lymphoma"
402:
567:
3021:
Li S, Strelow A, Fontana EJ, Wesche H (April 2002).
2019:
Li S, Strelow A, Fontana EJ, Wesche H (April 2002).
1622:"MyD88: a central player in innate immune signaling"
712:
MyD88-dependent toll-like receptor signaling pathway
3578:
3552:
3474:
3292:
3263:
3242:
1250:
Myeloid differentiation primary response 88 (MYD88)
1166:
1113:
1087:
1034:
767:
positive regulation of type I interferon production
1506:
1504:
1502:
1485:
1483:
1481:
349:
248:
1674:Abbas A, Lichtman AH, Pillai S (10 March 2017).
772:positive regulation of interleukin-23 production
752:positive regulation of interleukin-17 production
1932:
1930:
1878:
1876:
1874:
812:positive regulation of interleukin-8 production
737:positive regulation of interleukin-6 production
2076:
2074:
1511:GRCm38: Ensembl release 89: ENSMUSG00000032508
3447:
3212:
8:
1367:TIR domain-containing adapter-inducing IFN-β
1978:Chen BC, Wu WT, Ho FM, Lin WW (July 2002).
1490:GRCh38: Ensembl release 89: ENSG00000172936
1361:After ligand binding, all TLRs, apart from
782:defense response to Gram-positive bacterium
3454:
3440:
3432:
3296:
3219:
3205:
3197:
1708:: CS1 maint: location missing publisher (
1110:
1031:
867:
602:
390:
289:
186:
72:
3189:at the U.S. National Library of Medicine
3161:
3126:
3091:
3056:
3046:
3003:
2960:
2925:
2882:
2757:
2722:
2642:
2607:
2401:
2317:
2276:
2192:
2054:
2044:
1995:
1954:
1854:
1813:
1756:
1647:
1637:
822:interleukin-1-mediated signaling pathway
727:cellular response to mechanical stimulus
707:negative regulation of apoptotic process
1477:
1286:(TLRs), which belong to large group of
722:cell surface receptor signaling pathway
1701:
807:positive regulation of gene expression
747:toll-like receptor 9 signaling pathway
27:
2863:The Journal of Clinical Investigation
1292:Pathogen-associated molecular pattern
354:
315:
310:
253:
212:
207:
7:
1680:(Ninth ed.). Philadelphia, PA.
1669:
1667:
1296:damage-associated molecular patterns
717:toll-like receptor signaling pathway
3236:signal transducing adaptor proteins
2949:The Journal of Biological Chemistry
2746:The Journal of Biological Chemistry
2631:The Journal of Biological Chemistry
2306:The Journal of Biological Chemistry
1984:The Journal of Biological Chemistry
1943:The Journal of Biological Chemistry
1843:The New England Journal of Medicine
1620:Deguine J, Barton GM (2014-11-04).
1256:that, in humans, is encoded by the
802:type I interferon signaling pathway
732:regulation of inflammatory response
2740:Rhee SH, Hwang D (November 2000).
2300:Rhee SH, Hwang D (November 2000).
1163:
1084:
1007:
988:
962:
943:
917:
898:
762:3'-UTR-mediated mRNA stabilization
572:
490:
428:
407:
14:
1677:Cellular and molecular immunology
3331:Death-inducing signaling complex
2185:10.1128/MCB.21.14.4544-4552.2001
576:
338:
331:
325:
302:
237:
230:
224:
199:
36:
2918:10.1128/IAI.70.3.1272-1278.2002
1413:Waldenström's macroglobulinemia
2173:Molecular and Cellular Biology
1443:Interleukin 1 receptor, type I
587:More reference expression data
556:More reference expression data
1:
3005:10.1016/S0960-9822(02)00712-1
2588:Brain, Behavior, and Immunity
2538:10.1126/science.278.5343.1612
2464:10.1016/S0014-5793(96)01506-2
2103:10.1126/science.278.5343.1612
1591:10.1016/S0014-5793(96)01506-2
1409:diffuse large B-cell lymphoma
1288:pattern recognition receptors
817:defense response to bacterium
323:
222:
3664:Genes on human chromosome 3
3163:10.4049/jimmunol.170.7.3565
3093:10.4049/jimmunol.169.9.5209
2278:10.4049/jimmunol.170.7.3565
3695:
3255:JAK-STAT signaling pathway
3128:10.1182/blood-2002-08-2349
2555:Experimental Cell Research
2390:Molecular Medicine Reports
645:Toll-like receptor binding
20:
3407:
3299:
2600:10.1016/j.bbi.2016.12.012
1546:"Mouse PubMed Reference:"
1528:"Human PubMed Reference:"
1356:Toll-Interleukin receptor
1236:
1231:
1227:
1220:
1204:
1198:Chr 9: 119.17 – 119.17 Mb
1185:
1170:
1137:
1106:
1091:
1058:
1027:
1014:
1010:
995:
991:
982:
969:
965:
950:
946:
937:
924:
920:
905:
901:
892:
877:
870:
866:
850:
697:response to interleukin-1
635:identical protein binding
605:
601:
584:
575:
566:
553:
502:
493:
440:
431:
401:
393:
389:
372:
359:
322:
301:
292:
288:
271:
258:
221:
198:
189:
185:
140:
137:
127:
120:
115:
80:
75:
58:
53:
48:
44:
35:
30:
3191:Medical Subject Headings
2715:10.1093/emboj/19.13.3325
2644:10.1074/jbc.274.27.19403
1956:10.1074/jbc.274.27.19403
1423:Myd88 has been shown to
640:protein self-association
21:Not to be confused with
1749:10.1126/science.1158298
1191:Chr 3: 38.14 – 38.14 Mb
16:Protein found in humans
3267:receptor-bound protein
3048:10.1073/pnas.082100399
2962:10.1074/jbc.M201000200
2906:Infection and Immunity
2759:10.1074/jbc.M007386200
2567:10.1006/excr.1998.4131
2501:10.1006/geno.1997.4940
2319:10.1074/jbc.M007386200
2046:10.1073/pnas.082100399
1997:10.1074/jbc.M106014200
842:Toll signaling pathway
797:innate immune response
620:death receptor binding
3679:Genes mutated in mice
3580:Downstream signalling
3150:Journal of Immunology
3080:Journal of Immunology
2403:10.3892/mmr.2013.1769
2265:Journal of Immunology
1856:10.1056/NEJMoa1200710
757:inflammatory response
702:immune system process
510:stroma of bone marrow
480:palpebral conjunctiva
356:9 F3|9 71.33 cM
317:Chromosome 9 (mouse)
215:Chromosome 3 (human)
76:List of PDB id codes
49:Available structures
3039:2002PNAS...99.5567L
2996:2002CBio...12..467J
2789:2001Natur.413...78F
2662:Nature Cell Biology
2530:1997Sci...278.1612M
2126:Nature Cell Biology
2095:1997Sci...278.1612M
2037:2002PNAS...99.5567L
1897:2001Natur.413...78F
1806:10.1038/nature09671
1798:2011Natur.470..115N
1741:2008Sci...321..691V
1284:Toll-like receptors
777:signal transduction
464:gingival epithelium
1626:F1000Prime Reports
1467:ulcerative colitis
1460:Gene polymorphisms
972:ENSMUSG00000032508
690:Biological process
654:Cellular component
630:TIR domain binding
613:Molecular function
534:tibiofemoral joint
3651:
3650:
3469:signaling pathway
3463:Signaling pathway
3429:
3428:
3425:
3424:
2822:Nature Immunology
2343:Nature Immunology
2218:Nature Immunology
1687:978-0-323-52323-3
1247:
1246:
1243:
1242:
1216:
1215:
1181:
1180:
1160:
1159:
1102:
1101:
1081:
1080:
1023:
1022:
1004:
1003:
978:
977:
959:
958:
933:
932:
914:
913:
862:
861:
792:apoptotic process
671:endosome membrane
597:
596:
593:
592:
562:
561:
549:
548:
487:
486:
472:periodontal fiber
385:
384:
284:
283:
179:MYD88 - orthologs
111:
110:
107:
106:
59:Ortholog search:
3686:
3456:
3449:
3442:
3433:
3297:
3232:carrier proteins
3221:
3214:
3207:
3198:
3175:
3165:
3140:
3130:
3105:
3095:
3070:
3060:
3050:
3017:
3007:
2974:
2964:
2955:(19): 16456–63.
2939:
2929:
2896:
2886:
2875:10.1172/JCI14774
2853:
2816:
2797:10.1038/35092578
2771:
2761:
2752:(44): 34035–40.
2736:
2726:
2703:The EMBO Journal
2693:
2674:10.1038/35014038
2656:
2646:
2637:(27): 19403–10.
2621:
2611:
2578:
2549:
2524:(5343): 1612–5.
2512:
2483:
2446:
2416:
2415:
2405:
2381:
2375:
2374:
2338:
2332:
2331:
2321:
2312:(44): 34035–40.
2297:
2291:
2290:
2280:
2256:
2250:
2249:
2213:
2207:
2206:
2196:
2164:
2158:
2157:
2138:10.1038/35014038
2121:
2115:
2114:
2089:(5343): 1612–5.
2078:
2069:
2068:
2058:
2048:
2016:
2010:
2009:
1999:
1990:(27): 24169–79.
1975:
1969:
1968:
1958:
1949:(27): 19403–10.
1934:
1925:
1924:
1905:10.1038/35092578
1880:
1869:
1868:
1858:
1834:
1828:
1827:
1817:
1777:
1771:
1770:
1760:
1720:
1714:
1713:
1707:
1699:
1671:
1662:
1661:
1651:
1641:
1617:
1611:
1610:
1574:
1568:
1567:
1560:
1554:
1553:
1542:
1536:
1535:
1524:
1518:
1508:
1497:
1487:
1229:
1228:
1200:
1193:
1176:
1164:
1155:
1111:
1107:RefSeq (protein)
1097:
1085:
1076:
1032:
1008:
989:
963:
944:
918:
899:
868:
603:
589:
580:
573:
558:
498:
496:Top expressed in
491:
476:nasal epithelium
448:mononuclear cell
444:white blood cell
436:
434:Top expressed in
429:
408:
391:
381:
368:
357:
342:
335:
329:
318:
306:
290:
280:
267:
256:
241:
234:
228:
217:
203:
187:
181:
132:
125:
102:
73:
67:
46:
45:
40:
28:
3694:
3693:
3689:
3688:
3687:
3685:
3684:
3683:
3654:
3653:
3652:
3647:
3574:
3553:Other receptors
3548:
3470:
3460:
3430:
3421:
3403:
3288:
3259:
3238:
3225:
3183:
3178:
3143:
3121:(9): 3495–500.
3108:
3073:
3020:
2984:Current Biology
2977:
2942:
2899:
2856:
2819:
2783:(6851): 78–83.
2774:
2739:
2709:(13): 3325–36.
2696:
2659:
2624:
2581:
2552:
2515:
2486:
2449:
2437:(11): 2467–75.
2428:
2424:
2422:Further reading
2419:
2383:
2382:
2378:
2355:10.1038/ni.2284
2340:
2339:
2335:
2299:
2298:
2294:
2258:
2257:
2253:
2215:
2214:
2210:
2179:(14): 4544–52.
2166:
2165:
2161:
2123:
2122:
2118:
2080:
2079:
2072:
2018:
2017:
2013:
1977:
1976:
1972:
1936:
1935:
1928:
1891:(6851): 78–83.
1882:
1881:
1872:
1836:
1835:
1831:
1792:(7332): 115–9.
1779:
1778:
1774:
1735:(5889): 691–6.
1722:
1721:
1717:
1700:
1688:
1673:
1672:
1665:
1619:
1618:
1614:
1576:
1575:
1571:
1562:
1561:
1557:
1544:
1543:
1539:
1526:
1525:
1521:
1509:
1500:
1488:
1479:
1475:
1462:
1457:
1421:
1280:innate immunity
1269:
1238:View/Edit Mouse
1233:View/Edit Human
1196:
1189:
1186:Location (UCSC)
1172:
1151:
1147:
1143:
1139:
1133:
1129:
1125:
1121:
1117:
1093:
1072:
1068:
1064:
1060:
1054:
1050:
1046:
1042:
1038:
953:ENSG00000172936
846:
685:
666:plasma membrane
649:
625:protein binding
585:
554:
545:
540:
536:
532:
528:
524:
520:
516:
514:right lung lobe
512:
508:
494:
483:
478:
474:
470:
468:mucosa of ileum
466:
462:
458:
454:
450:
446:
432:
376:
363:
355:
345:
344:
343:
336:
316:
293:Gene location (
275:
262:
254:
244:
243:
242:
235:
213:
190:Gene location (
141:
128:
121:
82:
60:
26:
17:
12:
11:
5:
3692:
3690:
3682:
3681:
3676:
3674:Human proteins
3671:
3666:
3656:
3655:
3649:
3648:
3646:
3645:
3640:
3635:
3630:
3625:
3620:
3615:
3610:
3605:
3600:
3595:
3590:
3584:
3582:
3576:
3575:
3573:
3572:
3567:
3562:
3556:
3554:
3550:
3549:
3547:
3546:
3541:
3536:
3531:
3526:
3521:
3516:
3511:
3506:
3501:
3496:
3491:
3486:
3480:
3478:
3472:
3471:
3461:
3459:
3458:
3451:
3444:
3436:
3427:
3426:
3423:
3422:
3420:
3419:
3414:
3408:
3405:
3404:
3402:
3401:
3396:
3391:
3386:
3385:
3384:
3378:
3373:
3368:
3363:
3358:
3348:
3343:
3338:
3333:
3328:
3323:
3318:
3317:
3316:
3311:
3300:
3294:
3290:
3289:
3287:
3286:
3281:
3276:
3270:
3268:
3261:
3260:
3258:
3257:
3248:
3246:
3240:
3239:
3228:Cell signaling
3226:
3224:
3223:
3216:
3209:
3201:
3195:
3194:
3182:
3181:External links
3179:
3177:
3176:
3156:(7): 3565–71.
3141:
3106:
3086:(9): 5209–16.
3071:
3033:(8): 5567–72.
3018:
2975:
2940:
2897:
2854:
2817:
2772:
2737:
2694:
2657:
2622:
2579:
2550:
2513:
2484:
2447:
2425:
2423:
2420:
2418:
2417:
2376:
2333:
2292:
2271:(7): 3565–71.
2251:
2230:10.1038/ni1066
2224:(5): 495–502.
2208:
2159:
2116:
2070:
2031:(8): 5567–72.
2011:
1970:
1926:
1870:
1829:
1772:
1715:
1686:
1663:
1639:10.12703/P6-97
1612:
1569:
1555:
1537:
1519:
1498:
1476:
1474:
1471:
1461:
1458:
1456:
1455:
1450:
1445:
1440:
1435:
1429:
1420:
1417:
1385:
1384:
1378:
1358:(TIR) domain.
1268:
1265:
1245:
1244:
1241:
1240:
1235:
1225:
1224:
1218:
1217:
1214:
1213:
1211:
1209:
1202:
1201:
1194:
1187:
1183:
1182:
1179:
1178:
1168:
1167:
1161:
1158:
1157:
1135:
1134:
1108:
1104:
1103:
1100:
1099:
1089:
1088:
1082:
1079:
1078:
1056:
1055:
1029:
1025:
1024:
1021:
1020:
1012:
1011:
1005:
1002:
1001:
993:
992:
986:
980:
979:
976:
975:
967:
966:
960:
957:
956:
948:
947:
941:
935:
934:
931:
930:
922:
921:
915:
912:
911:
903:
902:
896:
890:
889:
884:
879:
875:
874:
864:
863:
860:
859:
848:
847:
845:
844:
839:
834:
829:
824:
819:
814:
809:
804:
799:
794:
789:
784:
779:
774:
769:
764:
759:
754:
749:
744:
739:
734:
729:
724:
719:
714:
709:
704:
699:
693:
691:
687:
686:
684:
683:
678:
673:
668:
663:
657:
655:
651:
650:
648:
647:
642:
637:
632:
627:
622:
616:
614:
610:
609:
599:
598:
595:
594:
591:
590:
582:
581:
570:
564:
563:
560:
559:
551:
550:
547:
546:
544:
543:
539:
535:
531:
527:
523:
519:
515:
511:
507:
503:
500:
499:
488:
485:
484:
482:
481:
477:
473:
469:
465:
461:
457:
453:
449:
445:
441:
438:
437:
425:
424:
416:
405:
399:
398:
395:RNA expression
387:
386:
383:
382:
374:
370:
369:
361:
358:
353:
347:
346:
337:
330:
324:
320:
319:
314:
308:
307:
299:
298:
286:
285:
282:
281:
273:
269:
268:
260:
257:
252:
246:
245:
236:
229:
223:
219:
218:
211:
205:
204:
196:
195:
183:
182:
139:
135:
134:
126:
118:
117:
113:
112:
109:
108:
105:
104:
78:
77:
69:
68:
57:
51:
50:
42:
41:
33:
32:
15:
13:
10:
9:
6:
4:
3:
2:
3691:
3680:
3677:
3675:
3672:
3670:
3669:Immune system
3667:
3665:
3662:
3661:
3659:
3644:
3641:
3639:
3636:
3634:
3631:
3629:
3626:
3624:
3621:
3619:
3616:
3614:
3611:
3609:
3606:
3604:
3601:
3599:
3596:
3594:
3591:
3589:
3586:
3585:
3583:
3581:
3577:
3571:
3568:
3566:
3563:
3561:
3558:
3557:
3555:
3551:
3545:
3542:
3540:
3537:
3535:
3532:
3530:
3527:
3525:
3522:
3520:
3517:
3515:
3512:
3510:
3507:
3505:
3502:
3500:
3497:
3495:
3492:
3490:
3487:
3485:
3482:
3481:
3479:
3477:
3473:
3468:
3464:
3457:
3452:
3450:
3445:
3443:
3438:
3437:
3434:
3418:
3415:
3413:
3410:
3409:
3406:
3400:
3397:
3395:
3392:
3390:
3387:
3382:
3379:
3377:
3374:
3372:
3369:
3367:
3364:
3362:
3359:
3357:
3354:
3353:
3352:
3349:
3347:
3344:
3342:
3339:
3337:
3334:
3332:
3329:
3327:
3324:
3322:
3319:
3315:
3312:
3310:
3307:
3306:
3305:
3302:
3301:
3298:
3295:
3291:
3285:
3282:
3280:
3277:
3275:
3272:
3271:
3269:
3266:
3265:Growth factor
3262:
3256:
3253:
3250:
3249:
3247:
3245:
3241:
3237:
3233:
3229:
3222:
3217:
3215:
3210:
3208:
3203:
3202:
3199:
3192:
3188:
3187:MyD88+Protein
3185:
3184:
3180:
3173:
3169:
3164:
3159:
3155:
3151:
3147:
3142:
3138:
3134:
3129:
3124:
3120:
3116:
3112:
3107:
3103:
3099:
3094:
3089:
3085:
3081:
3077:
3072:
3068:
3064:
3059:
3054:
3049:
3044:
3040:
3036:
3032:
3028:
3024:
3019:
3015:
3011:
3006:
3001:
2997:
2993:
2990:(6): 467–71.
2989:
2985:
2981:
2976:
2972:
2968:
2963:
2958:
2954:
2950:
2946:
2941:
2937:
2933:
2928:
2923:
2919:
2915:
2912:(3): 1272–8.
2911:
2907:
2903:
2898:
2894:
2890:
2885:
2880:
2876:
2872:
2869:(3): 419–25.
2868:
2864:
2860:
2855:
2851:
2847:
2843:
2839:
2835:
2834:10.1038/ni747
2831:
2827:
2823:
2818:
2814:
2810:
2806:
2802:
2798:
2794:
2790:
2786:
2782:
2778:
2773:
2769:
2765:
2760:
2755:
2751:
2747:
2743:
2738:
2734:
2730:
2725:
2720:
2716:
2712:
2708:
2704:
2700:
2695:
2691:
2687:
2683:
2679:
2675:
2671:
2668:(6): 346–51.
2667:
2663:
2658:
2654:
2650:
2645:
2640:
2636:
2632:
2628:
2623:
2619:
2615:
2610:
2605:
2601:
2597:
2593:
2589:
2585:
2580:
2576:
2572:
2568:
2564:
2560:
2556:
2551:
2547:
2543:
2539:
2535:
2531:
2527:
2523:
2519:
2514:
2510:
2506:
2502:
2498:
2494:
2490:
2485:
2481:
2477:
2473:
2469:
2465:
2461:
2457:
2453:
2448:
2444:
2440:
2436:
2432:
2427:
2426:
2421:
2413:
2409:
2404:
2399:
2395:
2391:
2387:
2380:
2377:
2372:
2368:
2364:
2360:
2356:
2352:
2349:(6): 535–42.
2348:
2344:
2337:
2334:
2329:
2325:
2320:
2315:
2311:
2307:
2303:
2296:
2293:
2288:
2284:
2279:
2274:
2270:
2266:
2262:
2255:
2252:
2247:
2243:
2239:
2235:
2231:
2227:
2223:
2219:
2212:
2209:
2204:
2200:
2195:
2190:
2186:
2182:
2178:
2174:
2170:
2163:
2160:
2155:
2151:
2147:
2143:
2139:
2135:
2132:(6): 346–51.
2131:
2127:
2120:
2117:
2112:
2108:
2104:
2100:
2096:
2092:
2088:
2084:
2077:
2075:
2071:
2066:
2062:
2057:
2052:
2047:
2042:
2038:
2034:
2030:
2026:
2022:
2015:
2012:
2007:
2003:
1998:
1993:
1989:
1985:
1981:
1974:
1971:
1966:
1962:
1957:
1952:
1948:
1944:
1940:
1933:
1931:
1927:
1922:
1918:
1914:
1910:
1906:
1902:
1898:
1894:
1890:
1886:
1879:
1877:
1875:
1871:
1866:
1862:
1857:
1852:
1849:(9): 826–33.
1848:
1844:
1840:
1833:
1830:
1825:
1821:
1816:
1811:
1807:
1803:
1799:
1795:
1791:
1787:
1783:
1776:
1773:
1768:
1764:
1759:
1754:
1750:
1746:
1742:
1738:
1734:
1730:
1726:
1719:
1716:
1711:
1705:
1697:
1693:
1689:
1683:
1679:
1678:
1670:
1668:
1664:
1659:
1655:
1650:
1645:
1640:
1635:
1631:
1627:
1623:
1616:
1613:
1608:
1604:
1600:
1596:
1592:
1588:
1584:
1580:
1573:
1570:
1565:
1559:
1556:
1551:
1547:
1541:
1538:
1533:
1529:
1523:
1520:
1516:
1512:
1507:
1505:
1503:
1499:
1495:
1491:
1486:
1484:
1482:
1478:
1472:
1470:
1468:
1459:
1454:
1451:
1449:
1446:
1444:
1441:
1439:
1436:
1434:
1431:
1430:
1428:
1426:
1418:
1416:
1414:
1410:
1405:
1400:
1395:
1393:
1389:
1382:
1379:
1375:
1372:
1371:
1370:
1368:
1364:
1359:
1357:
1353:
1349:
1345:
1341:
1337:
1333:
1329:
1325:
1321:
1317:
1313:
1309:
1308:
1303:
1299:
1297:
1293:
1289:
1285:
1281:
1276:
1274:
1266:
1264:
1262:
1259:
1255:
1251:
1239:
1234:
1230:
1226:
1223:
1219:
1212:
1210:
1207:
1203:
1199:
1195:
1192:
1188:
1184:
1177:
1175:
1169:
1165:
1162:
1156:
1154:
1150:
1146:
1142:
1136:
1132:
1128:
1124:
1120:
1116:
1112:
1109:
1105:
1098:
1096:
1090:
1086:
1083:
1077:
1075:
1071:
1067:
1063:
1057:
1053:
1049:
1045:
1041:
1037:
1033:
1030:
1028:RefSeq (mRNA)
1026:
1019:
1018:
1013:
1009:
1006:
1000:
999:
994:
990:
987:
985:
981:
974:
973:
968:
964:
961:
955:
954:
949:
945:
942:
940:
936:
929:
928:
923:
919:
916:
910:
909:
904:
900:
897:
895:
891:
888:
885:
883:
880:
876:
873:
869:
865:
858:
854:
849:
843:
840:
838:
835:
833:
830:
828:
825:
823:
820:
818:
815:
813:
810:
808:
805:
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800:
798:
795:
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790:
788:
785:
783:
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763:
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755:
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748:
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723:
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718:
715:
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679:
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638:
636:
633:
631:
628:
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623:
621:
618:
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615:
612:
611:
608:
607:Gene ontology
604:
600:
588:
583:
579:
574:
571:
569:
565:
557:
552:
541:
537:
533:
529:
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479:
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279:
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227:
220:
216:
210:
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202:
197:
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172:
168:
164:
160:
156:
152:
148:
144:
136:
131:
124:
119:
114:
103:
101:
97:
93:
89:
85:
79:
74:
71:
70:
66:
63:
56:
52:
47:
43:
39:
34:
29:
24:
19:
3617:
3340:
3251:
3153:
3149:
3118:
3114:
3083:
3079:
3030:
3026:
2987:
2983:
2952:
2948:
2909:
2905:
2866:
2862:
2825:
2821:
2780:
2776:
2749:
2745:
2706:
2702:
2665:
2661:
2634:
2630:
2591:
2587:
2561:(1): 67–75.
2558:
2554:
2521:
2517:
2495:(2): 332–9.
2492:
2488:
2455:
2452:FEBS Letters
2451:
2434:
2430:
2396:(1): 28–32.
2393:
2389:
2379:
2346:
2342:
2336:
2309:
2305:
2295:
2268:
2264:
2254:
2221:
2217:
2211:
2176:
2172:
2162:
2129:
2125:
2119:
2086:
2082:
2028:
2024:
2014:
1987:
1983:
1973:
1946:
1942:
1888:
1884:
1846:
1842:
1832:
1789:
1785:
1775:
1732:
1728:
1718:
1676:
1629:
1625:
1615:
1582:
1579:FEBS Letters
1578:
1572:
1558:
1549:
1540:
1531:
1522:
1463:
1422:
1419:Interactions
1396:
1386:
1360:
1334:) or within
1305:
1300:
1277:
1270:
1257:
1249:
1248:
1171:
1153:NP_001361717
1149:NP_001361716
1145:NP_001352806
1141:NP_001352805
1138:
1127:NP_001166040
1123:NP_001166039
1119:NP_001166038
1115:NP_001166037
1092:
1074:NM_001374788
1070:NM_001374787
1066:NM_001365877
1062:NM_001365876
1059:
1048:NM_001172569
1044:NM_001172568
1040:NM_001172567
1036:NM_001172566
1015:
996:
970:
951:
925:
906:
886:
881:
837:phagocytosis
418:
411:
377:119,170,477
364:119,165,000
138:External IDs
81:
18:
2828:(1): 91–7.
2594:: 326–339.
2458:(1): 81–4.
1585:(1): 81–4.
1469:was found.
522:ankle joint
506:granulocyte
456:granulocyte
276:38,143,022
263:38,138,478
116:Identifiers
3658:Categories
1517:, May 2017
1496:, May 2017
1473:References
1397:The human
1307:Drosophila
422:(ortholog)
159:HomoloGene
3326:Cortactin
1704:cite book
1696:973917896
1336:endosomes
1298:(DAMPs).
1174:NP_034981
1131:NP_002459
1095:NM_010851
1052:NM_002468
872:Orthologs
676:cytoplasm
530:esophagus
167:GeneCards
3336:Paxillin
3321:Caveolin
3244:JAK-STAT
3172:12646618
3137:12531807
3102:12391239
3067:11960013
3014:11909531
2971:11880380
2936:11854210
2893:11828002
2850:30884230
2842:11743586
2805:11544529
2768:10952994
2733:10880445
2690:32036101
2682:10854325
2653:10383454
2618:28007523
2489:Genomics
2480:44843127
2431:Oncogene
2412:24189845
2371:24438756
2363:22610250
2328:10952994
2287:12646618
2246:39773935
2238:15107846
2203:11416133
2154:32036101
2146:10854325
2065:11960013
2006:11976320
1965:10383454
1913:11544529
1865:22931316
1824:21179087
1767:18669862
1658:25580251
1607:44843127
1513:–
1492:–
1425:interact
1404:pyogenic
1399:ortholog
1377:immunity
1267:Function
1222:Wikidata
851:Sources:
542:duodenum
452:monocyte
3035:Bibcode
2992:Bibcode
2813:4333764
2785:Bibcode
2609:5453178
2575:9716450
2546:9374458
2526:Bibcode
2518:Science
2509:9344657
2472:9013863
2443:8957090
2111:9374458
2091:Bibcode
2083:Science
2033:Bibcode
1921:4333764
1893:Bibcode
1815:5024568
1794:Bibcode
1758:2688396
1737:Bibcode
1729:Science
1649:4229726
1599:9013863
1515:Ensembl
1494:Ensembl
1273:adapter
1254:protein
984:UniProt
939:Ensembl
878:Species
857:QuickGO
681:nucleus
661:cytosol
397:pattern
123:Aliases
3638:TOLLIP
3628:TICAM1
3613:MAP3K7
3394:SH3BP2
3304:14-3-3
3193:(MeSH)
3170:
3135:
3100:
3065:
3058:122810
3055:
3012:
2969:
2934:
2927:127773
2924:
2891:
2884:150862
2881:
2848:
2840:
2811:
2803:
2777:Nature
2766:
2731:
2724:313930
2721:
2688:
2680:
2651:
2616:
2606:
2573:
2544:
2507:
2478:
2470:
2441:
2410:
2369:
2361:
2326:
2285:
2244:
2236:
2201:
2191:
2152:
2144:
2109:
2063:
2056:122810
2053:
2004:
1963:
1919:
1911:
1885:Nature
1863:
1822:
1812:
1786:Nature
1765:
1755:
1694:
1684:
1656:
1646:
1632:: 97.
1605:
1597:
1427:with:
1208:search
1206:PubMed
1017:P22366
998:Q99836
894:Entrez
568:BioGPS
526:uterus
255:3p22.2
155:108005
147:602170
3643:TRAF6
3633:TIRAP
3618:MYD88
3603:IRAK4
3598:IRAK3
3593:IRAK2
3588:IRAK1
3544:TLR13
3539:TLR12
3534:TLR11
3529:TLR10
3381:TRAF6
3376:TRAF5
3371:TRAF4
3366:TRAF3
3361:TRAF2
3356:TRAF1
3341:MYD88
3314:YWHAZ
3309:YWHAE
3293:Other
3284:GRB10
3115:Blood
2846:S2CID
2809:S2CID
2686:S2CID
2476:S2CID
2367:S2CID
2242:S2CID
2194:87113
2150:S2CID
1917:S2CID
1603:S2CID
1453:TLR 4
1438:IRAK2
1433:IRAK1
1374:NF-κB
1258:MYD88
1252:is a
927:17874
887:Mouse
882:Human
853:Amigo
538:blood
460:blood
420:Mouse
413:Human
360:Start
295:Mouse
259:Start
192:Human
171:MYD88
130:MYD88
31:MYD88
3623:TAB1
3608:IRF3
3560:CD14
3524:TLR9
3519:TLR8
3514:TLR7
3509:TLR6
3504:TLR5
3499:TLR4
3494:TLR3
3489:TLR2
3484:TLR1
3476:TLRs
3417:CHML
3399:LDB3
3389:BIN1
3351:TRAF
3346:SMAD
3279:GRB7
3274:GRB2
3168:PMID
3133:PMID
3098:PMID
3063:PMID
3010:PMID
2967:PMID
2932:PMID
2889:PMID
2838:PMID
2801:PMID
2764:PMID
2729:PMID
2678:PMID
2649:PMID
2614:PMID
2571:PMID
2542:PMID
2505:PMID
2468:PMID
2439:PMID
2408:PMID
2359:PMID
2324:PMID
2283:PMID
2234:PMID
2199:PMID
2142:PMID
2107:PMID
2061:PMID
2002:PMID
1961:PMID
1909:PMID
1861:PMID
1820:PMID
1763:PMID
1710:link
1692:OCLC
1682:ISBN
1654:PMID
1595:PMID
1448:RAC1
1411:and
1392:TLR9
1390:and
1388:TLR7
1381:IRFs
1363:TLR3
1352:TLR9
1348:TLR8
1344:TLR7
1340:TLR3
1332:TLR6
1328:TLR5
1324:TLR4
1320:TLR2
1316:TLR1
1312:TLRs
1302:TLRs
1261:gene
908:4615
403:Bgee
351:Band
312:Chr.
250:Band
209:Chr.
163:1849
143:OMIM
100:4EO7
96:4DOM
92:3MOP
88:2Z5V
84:2JS7
65:RCSB
62:PDBe
23:MyoD
3570:MD2
3565:LBP
3467:TLR
3412:CHM
3252:see
3158:doi
3154:170
3123:doi
3119:101
3088:doi
3084:169
3053:PMC
3043:doi
3000:doi
2957:doi
2953:277
2922:PMC
2914:doi
2879:PMC
2871:doi
2867:109
2830:doi
2793:doi
2781:413
2754:doi
2750:275
2719:PMC
2711:doi
2670:doi
2639:doi
2635:274
2604:PMC
2596:doi
2563:doi
2559:243
2534:doi
2522:278
2497:doi
2460:doi
2456:402
2398:doi
2351:doi
2314:doi
2310:275
2273:doi
2269:170
2226:doi
2189:PMC
2181:doi
2134:doi
2099:doi
2087:278
2051:PMC
2041:doi
1992:doi
1988:277
1951:doi
1947:274
1901:doi
1889:413
1851:doi
1847:367
1810:PMC
1802:doi
1790:470
1753:PMC
1745:doi
1733:321
1644:PMC
1634:doi
1587:doi
1583:402
1278:In
518:lip
373:End
272:End
175:OMA
151:MGI
55:PDB
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