180:
about how the basal ganglia affected movement, or how disease of the basal ganglia caused the movement disorders seen in
Parkinson's disease. In meticulous experiments over several years, DeLong measured the firing of specific cells in the basal ganglia of awake monkeys when they performed specific trained movements.
195:
discovered that the same improvement could be achieved by placing a wire into the subthalamic nucleus, connecting it to a battery and delivering an adjustable high-frequency stimulation to the tip of the wire—a technique called deep brain stimulation. Today, this technique is used to improve symptoms
187:
In the 1980s, DeLong and his colleagues began to study monkeys with an experimentally-induced disease much like
Parkinson’s disease. He discovered that neurons in a part of the basal ganglia called the subthalamic nucleus were firing excessively, and that destroying (ablating) the subthalamic nucleus
179:
At the NIH, DeLong recorded the reactions of single brain cells in a part of the brain called the basal ganglia. At that time, it was known that the basal ganglia were involved in movement, and were the part of the brain most significantly affected in
Parkinson’s disease. However, little was known
175:
in
Bethesda, Maryland. In 1971, he and Russell T. Richardson did experiments with monkeys to find out first groups of neurons (nucleus basalis), which are involved in the pathogenesis conditioned learning and they revealed the role played by the neurotransmitter acetylcholine.
199:
For his work in understanding the circuits connecting the basal ganglia to other parts of the brain, and in applying that knowledge to develop a technique that has eased the suffering of many people with
Parkinson’s disease, DeLong was honored in 2014 with the
183:
Based on this work, and the work of others, DeLong and his colleagues identified a series of separate circuits that connect the basal ganglia with the cerebral cortex and thalamus. These circuits allow parallel processing of emotions, thoughts, and movement.
196:
and the quality of life in patients with
Parkinson’s disease who are not responding adequately to pharmacologic treatment. Ablation or deep brain stimulation of the subthalamic nucleus has transformed the lives of many people with Parkinson’s disease.
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117:(1938 in Des Moines – May 17, 2024 in Atlanta) was an American neurologist and professor at the Medical School of
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The same accomplishments were recognized by his receipt (with
Benabid) of the 2014
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In 1968, DeLong began five years of research training in the laboratory of
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Timeline
Behaviourist Approach, Matt Jarvis, Psychology Review, pdf
1124:
Recipients of the Lasker–DeBakey
Clinical Medical Research Award
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121:. His research has advanced the understanding and treatment of
160:. Since 1990, he has been a member of the faculty at
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in
Baltimore, and subsequently joined the faculty of
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402:
309:
87:
59:
43:
28:
21:
209:Lasker-DeBakey Clinical Medical Research Award
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8:
1129:Members of the National Academy of Medicine
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279:
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18:
678:The Event Horizon Telescope Collaboration
220:
148:(MD 1966), completed his internship at
253:"The Lasker Foundation - 2014 Awards"
7:
202:Breakthrough Prize in Life Sciences
14:
191:Shortly thereafter, neurosurgeon
16:American neurologist (1938–2024)
188:greatly improved the symptoms.
152:and his residency training at
1:
1109:Harvard Medical School alumni
173:National Institutes of Health
586:Sudbury Neutrino Observatory
510:Supernova Cosmology Project
1145:
1119:Stanford University alumni
108:
80:
1114:Emory University faculty
257:www.laskerfoundation.org
158:Johns Hopkins University
100:Johns Hopkins University
1004:Shankar Balasubramanian
740:Alexander Zamolodchikov
672:Peter van Nieuwenhuizen
1018:Clifford P. Brangwynne
851:Emmanuelle Charpentier
154:Johns Hopkins Hospital
146:Harvard Medical School
72:Harvard Medical School
1104:American neurologists
522:High-Z Supernova Team
961:Virginia Man-Yee Lee
825:Alexander Varshavsky
644:Jocelyn Bell Burnell
542:and contributors to
150:Boston City Hospital
137:movement disorders.
945:Jeffrey M. Friedman
835:Charles David Allis
520:and members of the
508:and members of the
142:Stanford University
123:Parkinson's disease
67:Stanford University
1038:Masashi Yanagisawa
949:Franz-Ulrich Hartl
879:Stephen J. Elledge
831:Alim Louis Benabid
718:Charles H. Bennett
668:Daniel Z. Freedman
618:Charles L. Bennett
582:Arthur B. McDonald
570:KĹŤichirĹŤ Nishikawa
500:John Henry Schwarz
490:Alexander Polyakov
468:Michel Della Negra
387:Daniel A. Spielman
302:Breakthrough Prize
193:Alim-Louis Benabid
1081:
1080:
1060:Fredrick Van Goor
953:Arthur L. Horwich
927:Adrian R. Krainer
821:Richard P. Lifton
779:Napoleone Ferrara
759:Cornelia Bargmann
608:Andrew Strominger
604:Joseph Polchinski
414:Nima Arkani-Hamed
363:Vincent Lafforgue
353:Christopher Hacon
112:
111:
82:Scientific career
51:(aged 85–86)
1136:
1072:Andrew Singleton
1022:Anthony A. Hyman
992:Jeffery W. Kelly
987:
979:Richard J. Youle
923:C. Frank Bennett
917:Don W. Cleveland
891:Yoshinori Ohsumi
817:Robert S. Langer
805:James P. Allison
767:Lewis C. Cantley
708:Hidetoshi Katori
688:Jens H. Gundlach
598:Super-Kamiokande
480:Joseph Incandela
464:Fabiola Gianotti
426:Maxim Kontsevich
381:Takuro Mochizuki
323:Maxim Kontsevich
295:
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259:. Archived from
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162:Emory University
140:DeLong attended
119:Emory University
115:Mahlon R. DeLong
95:Emory University
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1068:Ellen Sidransky
1048:Michel Sadelain
1034:Emmanuel Mignot
1008:David Klenerman
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971:Catherine Dulac
883:Harry F. Noller
861:Karl Deisseroth
847:Jennifer Doudna
813:Michael N. Hall
799:Bert Vogelstein
795:Shinya Yamanaka
791:Robert Weinberg
787:Charles Sawyers
745:
722:Gilles Brassard
702:Steven Weinberg
684:Eric Adelberger
594:YĹŤichirĹŤ Suzuki
506:Saul Perlmutter
472:Tejinder Virdee
456:Stephen Hawking
405:
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319:Simon Donaldson
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60:Alma mater
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1026:Demis Hassabis
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996:Katalin KarikĂł
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935:Xiaowei Zhuang
920:
909:Kazutoshi Mori
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775:Titia de Lange
763:David Botstein
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681:
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664:Sergio Ferrara
657:
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630:Lyman Page Jr.
626:Norman Jarosik
615:
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590:Takaaki Kajita
547:
546:project (2016)
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438:Nathan Seiberg
434:Juan Maldacena
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263:on 2014-09-11.
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839:Victor Ambros
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809:Mahlon DeLong
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751:Life sciences
748:
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730:Peter W. Shor
727:
726:David Deutsch
723:
719:
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692:Blayne Heckel
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634:David Spergel
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562:Atsuto Suzuki
559:
558:Daya Bay team
555:
551:
548:
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541:
537:
533:
532:Ronald Drever
529:
526:
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515:
514:Brian Schmidt
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496:Michael Green
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476:Guido Tonelli
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446:Edward Witten
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375:Martin Hairer
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23:Mahlon DeLong
20:
1012:Pascal Mayer
957:David Julius
939:Zhijian Chen
905:Peter Walter
901:Joanne Chory
873:Svante Pääbo
808:
771:Hans Clevers
697:
659:
650:Charles Kane
639:
622:Gary Hinshaw
540:Rainer Weiss
527:
486:(LHC) (2013)
451:
430:Andrei Linde
261:the original
256:
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236:
223:
206:
198:
190:
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182:
178:
166:
139:
135:neurological
114:
113:
88:Institutions
81:
49:(2024-05-17)
47:May 17, 2024
1099:2024 deaths
1094:1938 births
1030:John Jumper
982: [
967:David Baker
913:Kim Nasmyth
895:Huda Zoghbi
869:Helen Hobbs
843:Gary Ruvkun
783:Eric Lander
654:Eugene Mele
612:Cumrun Vafa
600:team (2016)
554:Kam-Biu Luk
550:Yifang Wang
460:Peter Jenni
404:Fundamental
331:Terence Tao
327:Jacob Lurie
311:Mathematics
144:(AB 1962),
54:Atlanta, US
1088:Categories
865:John Hardy
736:John Cardy
536:Kip Thorne
518:Adam Riess
482:(CMS) and
442:Ashoke Sen
369:Alex Eskin
215:References
133:and other
1044:Carl June
975:Dennis Lo
484:Lyn Evans
466:(ATLAS),
418:Alan Guth
304:laureates
241:Laureates
596:and the
584:and the
572:and the
564:and the
556:and the
341:Ian Agol
127:dystonia
698:Special
660:Special
640:Special
566:KamLAND
528:Special
452:Special
406:physics
171:at the
34: (
1074:(2024)
1040:(2023)
1014:(2022)
988:(2021)
963:(2020)
941:(2019)
919:(2018)
897:(2017)
875:(2016)
853:(2015)
827:(2014)
801:(2013)
742:(2024)
732:(2023)
714:(2022)
712:Jun Ye
704:(2021)
694:(2021)
680:(2020)
674:(2019)
656:(2019)
646:(2018)
636:(2018)
614:(2017)
588:team,
580:team,
568:team,
524:(2015)
502:(2014)
492:(2013)
448:(2012)
395:(2024)
389:(2023)
383:(2022)
377:(2021)
371:(2020)
365:(2019)
359:(2018)
349:(2017)
343:(2016)
337:(2015)
131:tremor
986:]
227:z.B.
1070:and
1010:and
925:and
871:and
849:and
823:and
797:and
738:and
710:and
690:and
652:and
592:and
544:LIGO
498:and
333:and
44:Died
36:1938
32:1938
29:Born
578:T2K
574:K2K
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