246:, along with the trypsin, which disturbed adhesion. The EDTA sequesters calcium ions, so Takeichi began testing for adhesion dependent on calcium. He used Chinese Hamster V79 cells and treated them with a variety of treatments, including EDTA, trypsin + EDTA, and trypsin + calcium. Once treated, these cells were tested for aggregation levels. He found that both calcium dependent and calcium independent pathways existed, and that the calcium treatment prevent trypsin's effects on the cell.
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230:, and since then he has contributed to clarify its functions in tissue construction and to understand the molecular mechanisms of cell adhesion. After his discovery of cadherins, he continued to research cadherins and their properties. Along with cadherins, he also researched cell junctions and adhesions. He continues to research at RIKEN today.
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Takeichi, along with other scientists, studied the mechanism behind hemagglutinin from
Botulism and its effect on the epithelial barrier of the intestines. They found the hemagglutinin directly interacted with the e-cadherin in the epithelial cells to disturbed cell to cell adhesion. This interaction
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family to be discovered. During this research, Takeichi also observed changes in the morphology of the cells involved with adhesions. He accurately hypothesized that the adhesions dependent on calcium played a role in managing cells' morphogenetic behavior. His discovery of the cadherin family led to
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Outside of cadherin, Takeichi studied other molecules involved with cell adhesion and beyond. He studied alpha-catenin functions outside of their functions within cell adhesion. The results showed alpha-catenin have a variety of functions outside of cadherin and adhesion. It regulates multiple
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Takeichi knew there was calcium dependent molecule that served an important role, but he had to find it. Rolf Kemler's anti serum was what helped him finally identify cadherin. E-cadherin was the first of the
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Hirano, S.; Kimoto, N.; Shimoyama, Y.; Hirohashi, S.; Takeichi, M. (1992). "Identification of a neural alpha-catenin as a key regulator of cadherin function and multicellular organization".
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from 1986 to 2002. During his time at Kyoto, he studied abroad at the
Carnegie Institute Department of Embryology for a fellowship. In 2000, he was appointed as Director of the
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to study cell adhesions and aggregation. Once he moved to the
Carnegie Institution, he realized the trypsin he was using behaved differently. This trypsin solution contained
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Nagafuchi, A.; Shirayoshi, Y.; Okazaki, K.; Yasuda, K.; Takeichi, M. (1987). "Transformation of cell adhesion properties by exogenously introduced E-cadherin cDNA".
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Yoshida, N.; Takeichi, M. (1982). "Teratocarcinoma cell adhesion: Identification of a cell surface protein involved in calcium-dependent cell aggregation".
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Hatta, K.; Takeichi, M. (1986). "Expression of N-cadherin adhesion molecules associated with early morphogenetic events in chicken embryos".
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Sugawara, Yo; Matsumura, Takuhiro; Takegahara, Yuki; Jin, Yingji; Tsukasaki, Yoshikazu; Takeichi, Masatoshi; Fujinaga, Yukako (2010-05-17).
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like cell to cell adhesion is dependent on calcium ions. An assay showed the hemaglutinin interaction is specific to e-cadherin.
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class of adhesion molecules, which plays important roles in the construction of tissues. He shared the 2005
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664:"Botulinum hemagglutinin disrupts the intercellular epithelial barrier by directly binding E-cadherin"
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Takeichi, Masatoshi (2018-10-01). "Multiple functions of α-catenin beyond cell adhesion regulation".
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Masatoshi
Takeichi, Foreign Associate of the National Academy of Sciences of U.S.A.
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648:"細胞から個体へ － 脇道から到達した発生生物学の本流" Biography of Masatoshi Takeichi
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American
Association for the Advancement of Science Fellow
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Foreign associates of the
National Academy of Sciences
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238:While first working in Kyoto, Takeichi was using
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624:Dr Masatoshi Takeichi, Laureate of Japan Prize
580:"The sticky business of discovering cadherins"
218:Center for Developmental Biology (RIKEN CDB).
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151:known for his identification of the
333:Canada Gairdner International Award
166:He was selected as a Member of the
84:Canada Gairdner International Award
1445:Academic staff of Kyoto University
321:Thomson Reuters Citation Laureates
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1440:21st-century Japanese biologists
234:Discovery of the Cadherin Family
210:, and he served as Professor of
1251:/ John Frederick Grassle (2013)
721:Current Opinion in Cell Biology
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961:Ernest John Christopher Polge
522:10.1016/0092-8674(92)90103-j
403:10.1016/0092-8674(82)90339-7
226:In 1977 Takeichi discovered
172:National Academy of Sciences
668:The Journal of Cell Biology
584:The Journal of Cell Biology
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303:Keio Medical Science Prize
977:William Hayward Pickering
852:Ephraim Katchalski-Katzir
733:10.1016/j.ceb.2018.02.014
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1460:Nagoya University alumni
1430:Developmental biologists
309:Person of Cultural Merit
178:Early life and education
1465:Kyoto University alumni
1118:/ Keith J. Sainsbury /
794:Gairdner Laureates 2020
1455:Scientists from Nagoya
1289:Emmanuelle Charpentier
908:Frank Sherwood Rowland
279:Chunichi Culture Award
222:Research contributions
680:10.1083/jcb.200910119
182:Takeichi was born in
1394:John Michael Wallace
364:10.1083/jcb.75.2.464
346:Takeichi, M (1977).
1378:/ Kazuo Hagimoto /
1217:Tadamitsu Kishimoto
947:Jacques-Louis Lions
596:10.1083/jcb1704fta1
578:Powell, K. (2005).
477:1987Natur.329..341N
291:Japan Academy Prize
259:Other contributions
190:, and his Ph.D. in
70:Ross Harrison Prize
1356:Robert A. Weinberg
1338:Robert G. Gallager
1283:Steven D. Tanksley
1269:Theodore Friedmann
1172:Victor A. McKusick
1130:Masatoshi Takeichi
1078:Timothy R. Parsons
1074:John B. Goodenough
1068:Kimishige Ishizaka
1043:Jack L. Strominger
1039:W. Wesley Peterson
1019:Hiroyuki Yoshikawa
1015:Joseph Engelberger
991:Edward F. Knipling
771:"Historic Fellows"
130:Masatoshi Takeichi
23:Masatoshi Takeichi
16:Japanese biologist
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1199:Shun-ichi Iwasaki
1158:Peter Shaw Ashton
1098:Benoit Mandelbrot
1092:Andrzej Tarkowski
912:Elias James Corey
723:. Cell Dynamics.
471:(6137): 341–343.
434:(6061): 447–449.
188:Nagoya University
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94:Scientific career
50:Nagoya University
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1126:Makoto Nagao
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1029:Jozef Schell
957:Gerhard Ertl
951:John J. Wild
937:Dan McKenzie
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110:Institutions
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1420:1943 births
1150:Albert Fert
1106:Seiji Ogawa
967:Frank Press
833:Japan Prize
315:Japan Prize
285:Asahi Prize
272:Recognition
157:Japan Prize
77:Japan Prize
38:Nationality
1414:Categories
1321:Rattan Lal
1297:Adi Shamir
1144:Akira Endo
1064:Ian McHarg
1011:Bruce Ames
890:Isao Arita
835:recipients
780:2019-12-06
590:(4): 514.
560:References
212:Biophysics
198:in 1973.
192:Biophysics
1164:Vint Cerf
1025:Leo Esaki
1001:Masao Ito
741:0955-0674
727:: 24–29.
688:0021-9525
749:29525243
706:20457762
538:29963709
419:44294728
252:cadherin
228:cadherin
153:cadherin
60:Cadherin
41:Japanese
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473:Bibcode
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448:3515198
411:7060128
373:2109947
240:trypsin
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136:竹市 雅俊
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