55:
1888:
Yonezawa, Toshiya; Mizuno, Seiya; Miyazaki, Shinichi; Connor, Linzi; Kumar, Vivek; Miura, Ikuo; Suzuki, Tomohiro; Watanabe, Atsushi; Abe, Manabu; Sugiyama, Fumihiro; Takahashi, Satoru; Sakimura, Kenji; Hayashi, Yu; Liu, Qinghua; Kume, Kazuhiko; Wakana, Shigeharu; Takahashi, Joseph S.; Yanagisawa, Masashi (2016).
1679:
Tanaka, Hirokazu; Yoshida, Tetsuo; Miyamoto, Norimasa; Motoike, Toshiyuki; Kurosu, Hiroshi; Shibata, Kenji; Yamanaka, Akihiro; Williams, S. Clay; Richardson, James A.; Tsujino, Natsuko; Garry, Mary G.; Lerner, Michael R.; King, David S.; O'Dowd, Brian F.; Sakurai, Takeshi; Yanagisawa, Masashi (2003).
1798:
Takayasu, Shinobu; Sakurai, Takeshi; Iwasaki, Satoshi; Teranishi, Hitoshi; Yamanaka, Akihiro; Williams, S. Clay; Iguchi, Haruhisa; Kawasawa, Yuka
Imamura; Ikeda, Yukio; Sakakibara, Iori; Ohno, Kousaku; Ioka, Ryoichi X.; Murakami, Saori; Dohmae, Naoshi; Xie, Jian; Suda, Toshihiro; Motoike, Toshiyuki;
1887:
Funato, Hiromasa; Miyoshi, Chika; Fujiyama, Tomoyuki; Kanda, Takeshi; Sato, Makito; Wang, Zhiqiang; Ma, Jing; Nakane, Shin; Tomita, Jun; Ikkyu, Aya; Kakizaki, Miyo; Hotta-Hirashima, Noriko; Kanno, Satomi; Komiya, Haruna; Asano, Fuyuki; Honda, Takato; Kim, Staci J.; Harano, Kanako; Muramoto, Hiroki;
1403:
Sakurai, Takeshi; Amemiya, Akira; Ishii, Makoto; Matsuzaki, Ichiyo; Chemelli, Richard M.; Tanaka, Hirokazu; Williams, S. Clay; Richardson, James A.; Kozlowski, Gerald P.; Wilson, Shelagh; Arch, Jonathan R. S.; Buckingham, Robin E.; Haynes, Andrea C.; Carr, Steven A.; Annan, Roland S.; McNulty, Dean
455:
substance. During his PhD study, Yanagisawa's supervisor, Tomoh Masaki, agreed to let him try to isolate the substance. This study became his PhD thesis, and he published his finding it 1988, naming the substance "endothelin" and reporting its peptide sequence. He then published a number of reports
1945:
Wang, Zhiqiang; Ma, Jing; Miyoshi, Chika; Li, Yuxin; Sato, Makito; Ogawa, Yukino; Lou, Tingting; Ma, Chengyuan; Gao, Xue; Lee, Chiyu; Fujiyama, Tomoyuki; Yang, Xiaojie; Zhou, Shuang; Hotta-Hirashima, Noriko; Klewe-Nebenius, Daniela; Ikkyu, Aya; Kakizaki, Miyo; Kanno, Satomi; Cao, Liqin; Takahashi,
1622:
Peyron, Christelle; Faraco, Juliette; Rogers, William; Ripley, Beth; Overeem, Sebastiaan; Charnay, Yves; Nevsimalova, Sona; Aldrich, Michael; Reynolds, David; Albin, Roger; Li, Robin; Hungs, Marcel; Pedrazzoli, Mario; Padigaru, Muralidhara; Kucherlapati, Melanie; Fan, Jun; Maki, Richard; Lammers,
1568:
Chemelli, Richard M.; Willie, Jon T.; Sinton, Christopher M.; Elmquist, Joel K.; Scammell, Thomas; Lee, Charlotte; Richardson, James A.; Williams, S. Clay; Xiong, Yumei; Kisanuki, Yaz; Fitch, Thomas E.; Nakazato, Masamitsu; Hammer, Robert E.; Saper, Clifford B.; Yanagisawa, Masashi (1999).
1445:
de Lecea, L.; Kilduff, T. S.; Peyron, C.; Gao, X.-B.; Foye, P. E.; Danielson, P. E.; Fukuhara, C.; Battenberg, E. L. F.; Gautvik, V. T.; Bartlett, II, F. S.; Frankel, W. N.; van den Pol, A. N.; Bloom, F. E.; Gautvik, K. M.; Sutcliffe, J. G. (1998).
396:
He returned to Japan in 2012 to found and direct the
International Institute for Integrative Sleep Medicine at the University of Tsukuba, which was established under the World Premier International Research Center Initiative by Japan's
329:
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270:
173:
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Yanagisawa, Masashi; Kurihara, Hiroki; Kimura, Sadao; Tomobe, Yoko; Kobayashi, Mieko; Mitsui, Youji; Yazaki, Yoshio; Goto, Katsutoshi; Masaki, Tomoh (1988).
2322:
2034:
3358:
2124:
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470:(UTSW) in the United States, for example discovering one of the mechanisms to activate endothelin and that a mutation in endothelin receptor can cause
3343:
2912:
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942:
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555:, whose cause at the time was still unknown. The association between orexin and narcolepsy was definitively established not long afterwards in 2000.
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Xiong, Yumei; Miyamoto, Norimasa; Shibata, Kenji; Valasek, Mark A.; Motoike, Toshiyuki; Kedzierski, Rafal M.; Yanagisawa, Masashi (2004).
2985:
2422:
913:
728:
379:
142:
2479:
3378:
1406:"Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior"
2545:
2038:
1801:"A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice"
54:
1508:
882:
2296:
1024:
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406:
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Sakurai, Takeshi; Yanagisawa, Masashi; Takuwa, Yoh; Miyazaki, Hitoshi; Kimura, Sadao; Goto, Katsutoshi; Masaki, Tomoh (1990).
3368:
2952:
2569:
2418:
2236:
1625:"A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains"
698:
2299:(in Japanese). International Institute for Integrative Sleep Medicine, University of Tsukuba. April 28, 2016. Archived from
3338:
2003:
1509:"International Union of Basic and Clinical Pharmacology. LXXXVI. Orexin receptor function, nomenclature and pharmacology"
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567:
563:
3025:
2744:
2068:
2007:
1682:"Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8"
1345:
Puffenberger, Erik G.; Hosoda, Kiminori; Washington, Sarah S.; Nakao, Kazuwa; deWit, Damiane; Yanagisawa, Masashi;
810:
716:
671:
644:
631:
571:
489:
134:
122:
118:
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Xu, Dong; Emoto, Noriaki; Giaid, Adel; Slaughter, Clive; Kaw, Semiko; deWit, Damiane; Yanagisawa, Masashi (1994).
2730:
2337:
2042:
848:
551:
in mice, hoping to see the animal eating less. Instead, they observed behavior similar to the human condition of
471:
1861:
1741:"Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41"
1404:
E.; Liu, Wu-Schyong; Terrett, Jonathan A.; Elshourbagy, Nabil A.; Bergsma, Derk J.; Yanagisawa, Masashi (1998).
194:
3201:
2132:
722:
138:
2804:
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524:) made the same discovery in the same year, and named the neuropeptide "hypocretin". Today, "hypocretin" (or
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1513:
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126:
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and increased blood flow. This led to the speculation of and hunt for the inverse, an endothelium-derived
286:
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Gotter, Anthony L.; Webber, Andrea L.; Coleman, Paul J.; Renger, John J.; Winrow, Christopher J. (2012).
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1291:"ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1"
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on the function and regulation of endothelin, including working with
Takeshi Sakurai to identify the
344:
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325:. One year later, he became an assistant professor at the same department, and in 1991 moved to the
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492:(GPCRs). In 1998, again teaming up with Takeshi Sakurai, who has moved to the United States as a
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383:
364:
302:
266:
107:
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779:
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Yanagisawa was born in Tokyo in 1960. His father was a surgeon and, thanks to his background in
1946:
Satoru; Peng, Junmin; Yu, Yonghao; Funato, Hiromasa; Yanagisawa, Masashi; Liu, Qinghua (2018).
1864:. International Institute for Integrative Sleep Medicine, University of Tsukuba. Archived from
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1985:
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261:. He is currently the Director of the International Institute for Integrative Sleep Medicine,
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1362:
1351:"A missense mutation of the endothelin-B receptor gene in multigenic hirschsprung's disease"
1304:
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Gert Jan; Bouras, Constantin; Kucherlapati, Raju; Nishino, Seiji; Mignot, Emmanuel (2000).
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2740:
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1629:
1221:"Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor"
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1980:
1947:
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1835:
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1295:
879:"An exclusive interview with Masashi Yanagisawa from discovery of Endothelin to Orexin"
505:
477:
Eventually, his interest in endothelin diminished and
Yanagisawa switched his focus to
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1740:
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684:
544:
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382:
ERATO (Exploratory
Research for Advanced Technology) scheme, focusing on discovering
30:
22:
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1658:
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1608:
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1002:
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672:
Bristol-Myers Squibb Award for
Distinguished Achievement in Cardiovascular Research
509:
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448:
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432:
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318:
251:
123:
Bristol-Myers Squibb Award for
Distinguished Achievement in Cardiovascular Research
2426:
2244:
1948:"Quantitative phosphoproteomic analysis of the molecular substrates of sleep need"
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3017:
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710:
638:
Robert J. and Claire
Pasarow Foundation Award in Cardiovascular Medical Research
618:
436:
352:
130:
2505:
1448:"The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity"
1149:"A novel potent vasoconstrictor peptide produced by vascular endothelial cells"
1081:
3121:
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2770:
2752:
2676:
2603:
2011:
1971:
751:
552:
421:
305:
in 1985, he pursued a PhD at the same institute, completing it 3 years later.
258:
247:
195:
A novel potent vasoconstrictor peptide produced by vascular endothelial cells
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1989:
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1913:
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Immediately after obtaining his PhD, Yanagisawa started his career as a
2267:"Sleep Medicine Professional Wins American Physiological Society Award"
537:
508:
word for appetite, since the neuropeptide was found exclusively in the
418:
244:
516:
consumed more food after receiving a dose of orexin. Another group at
2946:
2365:(in Japanese). University of Tsukuba. January 4, 2018. Archived from
1865:
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1110:
501:
428:
254:
188:
1642:
559:
336:
1890:"Forward-genetics analysis of sleep in randomly mutagenized mice"
562:
and orphan receptors. For example, he uncovered the functions of
2778:
548:
529:
496:
at UTSW, Yanagisawa connected two orphan GPCRs with a family of
2509:
2099:
American
Society for Pharmacology and Experimental Therapeutics
652:
American
Society for Pharmacology and Experimental Therapeutics
2393:
Ministry of Education, Culture, Sports, Science and Technology
399:
Ministry of Education, Culture, Sports, Science and Technology
332:
as an assistant professor at the Department of Pharmacology.
2449:"Clarivate Citation Laureates 2023_Physiology or Medicine"
1799:
Ohuchi, Takashi; Yanagisawa, Masashi; Sakai, Juro (2006).
1001:. University of Tsukuba. November 29, 2016. Archived from
945:. International Institute for Integrative Sleep Medicine,
401:. Two years later, he switched to part-time at UTSW as an
3404:
Members of the United States National Academy of Sciences
375:
Distinguished Chair in Basic Biomedical Science in 1998.
609:
gene) in regulating sleep. His team also identified the
558:
Since then, his research has mostly focused on studying
378:
Between 2001 and 2006, he had his own project under the
3364:
University of Texas Southwestern Medical Center faculty
417:
Yanagisawa is most well known for his discovery of the
1575:
Knockout Mice: Molecular Genetics of Sleep Regulation"
659:
American Society of Biochemistry and Molecular Biology
617:
of 80 proteins as a major regulation mechanism of the
512:, a brain region that regulates appetite, and because
975:. Japan Science and Technology Agency. Archived from
2035:"Pasarow awards honor three outstanding researchers"
2984:
2637:
2544:
2155:"Bristol-Myers Squibb 'Freedom to Discover' Awards"
205:
187:
165:
155:
114:
99:
91:
83:
61:
38:
754:since his second year of PhD. He plays the flute.
466:He kept studying endothelin after moving to the
265:, and an adjunct professor at the Department of
2480:"【インタビュー】柳沢正史さん（後編） 科学の発見は「何とかなる」という信仰に支えられている"
1805:Proceedings of the National Academy of Sciences
1745:Proceedings of the National Academy of Sciences
1686:Proceedings of the National Academy of Sciences
1453:Proceedings of the National Academy of Sciences
597:, Yanagisawa and his team reported the role of
488:have yet to be identified, particularly orphan
468:University of Texas Southwestern Medical Center
357:University of Texas Southwestern Medical Center
271:University of Texas Southwestern Medical Center
243:and physician, famous for his discovery of the
232:
174:University of Texas Southwestern Medical Center
2065:"The Novartis Award For Hypertension Research"
226:
2521:
904:
902:
900:
405:. Yanagisawa was also an investigator at the
8:
1057:(Press release). Nobel Prize. Archived from
3354:Academic staff of the University of Tsukuba
778:(in Japanese). Nature Japan. Archived from
409:during his time working full-time at UTSW.
351:laureates and famous for their research in
3384:Recipients of the Medal with Purple Ribbon
2528:
2514:
2506:
769:
767:
643:Novartis Award For Hypertension Research,
53:
35:
2913:The Event Horizon Telescope Collaboration
2170:
1979:
1921:
1834:
1824:
1774:
1764:
1715:
1705:
1590:
1483:
1473:
1421:
1180:
536:, while "orexin" is used to refer to the
877:Korkutata, Mustafa (September 7, 2020).
3389:Japanese emigrants to the United States
763:
257:, the absence of which is the cause of
3394:American academics of Japanese descent
1856:
1854:
937:
935:
801:
799:
797:
431:. Early 1980s saw the revelation that
301:to study medicine. After obtaining an
910:"Masashi Yanagisawa Research History"
349:Nobel Prize in Physiology or Medicine
295:Musashi Junior and Senior High School
7:
3399:American scientists of Asian descent
836:
834:
832:
650:John J. Abel Award in Pharmacology,
585:approach, which randomly introduced
2423:Breakthrough Prize in Life Sciences
914:Japan Science and Technology Agency
729:Breakthrough Prize in Life Sciences
380:Japan Science and Technology Agency
143:Breakthrough Prize in Life Sciences
3359:Academic staff of Kyoto University
2395:. November 3, 2019. Archived from
2172:10.1097/01.COT.0000290764.24899.c9
2125:"Prize recipients: Jacobæus Prize"
1862:"柳沢 正史 Masashi Yanagisawa, MD PhD"
14:
2039:University of Southern California
842:"Masashi Yanagisawa, M.D., Ph.D."
705:Medal of Honor with Purple Ribbon
581:More recently, using an unbiased
500:as their ligands. They named it "
127:Medal of Honor with Purple Ribbon
3344:21st-century Japanese biologists
2273:. April 10, 2015. Archived from
1082:"Endothelins come home to roost"
747:Yanagisawa is married, and is a
605:gene) and NALCN (encoded by the
589:in mice and then observed their
1029:Howard Hughes Medical Institute
407:Howard Hughes Medical Institute
339:only for one year, after which
178:Howard Hughes Medical Institute
699:American Physiological Society
518:The Scripps Research Institute
371:in 1996, and endowed with the
293:researcher. He graduated from
1:
3409:Japanese molecular biologists
2486:(in Japanese). Archived from
2033:Emerson, Eva (May 15, 1998).
1592:10.1016/s0092-8674(00)81973-x
1423:10.1016/s0092-8674(00)80949-6
1025:"Masashi Yanagisawa, MD, PhD"
543:Yanagisawa and his team then
3374:University of Tsukuba alumni
2821:Sudbury Neutrino Observatory
2453:Clarivate Citation Laureates
2211:National Academy of Sciences
1367:10.1016/0092-8674(94)90016-7
1309:10.1016/0092-8674(94)90425-1
973:"YANAGISAWA Orphan Receptor"
735:Clarivate Citation Laureates
679:National Academy of Sciences
481:, which are receptors whose
33:when mentioning individuals.
16:Japanese molecular biologist
2745:Supernova Cosmology Project
2237:"The Ulf von Euler lecture"
847:. Institute of Physiology,
490:G protein-coupled receptors
233:
3425:
2478:坂本, 直子 (October 7, 2018).
2069:American Heart Association
2008:Kilby International Awards
2004:"The 1998 Kilby Laureates"
811:Keio Medical Science Prize
717:Keio Medical Science Prize
645:American Heart Association
632:Kilby International Awards
528:) is used to refer to the
135:Keio Medical Science Prize
119:Kilby International Awards
20:
3379:Persons of Cultural Merit
1972:10.1038/s41586-018-0218-8
849:Czech Academy of Sciences
297:in 1979, and entered the
227:
215:
148:
52:
45:
723:Person of Cultural Merit
277:Early life and education
139:Person of Cultural Merit
29:. This article uses
21:The native form of this
3239:Shankar Balasubramanian
2975:Alexander Zamolodchikov
2907:Peter van Nieuwenhuizen
2363:"柳沢正史教授の2017年度朝日賞受賞が決定"
2129:Novo Nordisk Foundation
1826:10.1073/pnas.0602371103
1766:10.1073/pnas.2637002100
1707:10.1073/pnas.0837789100
1514:Pharmacological Reviews
666:Novo Nordisk Foundation
359:(UTSW). He began as an
355:, recruited him to the
239:is a Japanese-American
3253:Clifford P. Brangwynne
3086:Emmanuelle Charpentier
2323:"平成２８年春の褒章受章者名簿 在日外国人"
472:Hirschsprung's disease
287:electronic engineering
3369:Scientists from Tokyo
2757:High-Z Supernova Team
2459:on September 19, 2023
1527:10.1124/pr.111.005546
1475:10.1073/pnas.95.1.322
1347:Chakravarti, Aravinda
947:University of Tsukuba
439:produce to relax the
363:at the Department of
335:Yanagisawa stayed at
323:University of Tsukuba
317:at the Department of
299:University of Tsukuba
263:University of Tsukuba
182:University of Tsukuba
104:University of Tsukuba
3339:Molecular biologists
3196:Virginia Man-Yee Lee
3060:Alexander Varshavsky
2879:Jocelyn Bell Burnell
2777:and contributors to
2419:"Masashi Yanagisawa"
2343:on November 22, 2022
2303:on November 22, 2022
2277:on November 20, 2022
2241:Karolinska Institute
2217:on November 22, 2022
2207:"Masashi Yanagisawa"
2187:on November 20, 2022
2135:on November 19, 2022
2105:on November 19, 2022
2095:"John J. Abel Award"
2075:on November 17, 2022
2045:on November 19, 2022
2014:on November 17, 2022
1868:on November 17, 2022
1549:on November 14, 2022
1005:on November 15, 2022
999:"Masashi Yanagisawa"
979:on November 15, 2022
943:"Masashi Yanagisawa"
885:on November 14, 2022
807:"柳沢 正史（やなぎさわ まさし）博士"
689:Karolinska Institute
345:Michael Stuart Brown
237:, born May 25, 1960)
3349:American biologists
3180:Jeffrey M. Friedman
3070:Charles David Allis
2755:and members of the
2743:and members of the
2490:on November 4, 2022
2429:on November 3, 2022
2399:on January 18, 2022
2369:on January 29, 2018
2334:Government of Japan
1964:2018Natur.558..435W
1914:10.1038/nature20142
1906:2016Natur.539..378F
1817:2006PNAS..103.7438T
1757:2004PNAS..101.1045X
1698:2003PNAS..100.6251T
1466:1998PNAS...95..322D
1237:1990Natur.348..732S
1165:1988Natur.332..411Y
1103:1990Natur.348..673V
1080:Vane, John (1990).
1061:on November 8, 2022
1035:on November 3, 2022
953:on November 6, 2022
920:on November 6, 2022
858:on November 3, 2022
817:on November 4, 2022
782:on November 4, 2022
697:Award Lectureship,
494:postdoctoral fellow
373:Patrick E. Haggerty
361:associate professor
341:Joseph L. Goldstein
315:postdoctoral fellow
241:molecular biologist
3273:Masashi Yanagisawa
3184:Franz-Ulrich Hartl
3114:Stephen J. Elledge
3066:Alim Louis Benabid
2953:Charles H. Bennett
2903:Daniel Z. Freedman
2853:Charles L. Bennett
2817:Arthur B. McDonald
2805:Kōichirō Nishikawa
2735:John Henry Schwarz
2725:Alexander Polyakov
2703:Michel Della Negra
2622:Daniel A. Spielman
2537:Breakthrough Prize
435:was the substance
367:, was promoted to
365:Molecular genetics
330:School of Medicine
267:Molecular Genetics
234:Yanagisawa Masashi
222:Masashi Yanagisawa
40:Masashi Yanagisawa
31:Western name order
27:Yanagisawa Masashi
3316:
3315:
3295:Fredrick Van Goor
3188:Arthur L. Horwich
3162:Adrian R. Krainer
3056:Richard P. Lifton
3014:Napoleone Ferrara
2994:Cornelia Bargmann
2843:Andrew Strominger
2839:Joseph Polchinski
2649:Nima Arkani-Hamed
2598:Vincent Lafforgue
2588:Christopher Hacon
2297:"柳沢正史機構長が紫綬褒章を受章"
1958:(7710): 435–439.
1900:(7629): 378–383.
1811:(19): 7438–7443.
1692:(10): 6251–6256.
1231:(6303): 732–735.
1159:(6163): 411–415.
625:Honors and awards
615:dephosphorylation
591:electrocardiogram
437:endothelial cells
403:adjunct professor
291:electrophysiology
219:
218:
160:Molecular biology
150:Scientific career
3416:
3307:Andrew Singleton
3257:Anthony A. Hyman
3227:Jeffery W. Kelly
3222:
3214:Richard J. Youle
3158:C. Frank Bennett
3152:Don W. Cleveland
3126:Yoshinori Ohsumi
3052:Robert S. Langer
3040:James P. Allison
3002:Lewis C. Cantley
2943:Hidetoshi Katori
2923:Jens H. Gundlach
2833:Super-Kamiokande
2715:Joseph Incandela
2699:Fabiola Gianotti
2661:Maxim Kontsevich
2616:Takuro Mochizuki
2558:Maxim Kontsevich
2530:
2523:
2516:
2507:
2500:
2499:
2497:
2495:
2475:
2469:
2468:
2466:
2464:
2455:. Archived from
2445:
2439:
2438:
2436:
2434:
2425:. Archived from
2415:
2409:
2408:
2406:
2404:
2385:
2379:
2378:
2376:
2374:
2359:
2353:
2352:
2350:
2348:
2342:
2336:. Archived from
2327:
2319:
2313:
2312:
2310:
2308:
2293:
2287:
2286:
2284:
2282:
2263:
2257:
2256:
2254:
2252:
2243:. Archived from
2233:
2227:
2226:
2224:
2222:
2213:. Archived from
2203:
2197:
2196:
2194:
2192:
2183:. Archived from
2174:
2165:(22): 58. 2003.
2151:
2145:
2144:
2142:
2140:
2131:. Archived from
2121:
2115:
2114:
2112:
2110:
2101:. Archived from
2091:
2085:
2084:
2082:
2080:
2071:. Archived from
2061:
2055:
2054:
2052:
2050:
2041:. Archived from
2030:
2024:
2023:
2021:
2019:
2010:. Archived from
2000:
1994:
1993:
1983:
1942:
1936:
1935:
1925:
1884:
1878:
1877:
1875:
1873:
1858:
1849:
1848:
1838:
1828:
1795:
1789:
1788:
1778:
1768:
1751:(4): 1045–1050.
1736:
1730:
1729:
1719:
1709:
1676:
1670:
1669:
1667:
1665:
1619:
1613:
1612:
1594:
1565:
1559:
1558:
1556:
1554:
1545:. Archived from
1504:
1498:
1497:
1487:
1477:
1442:
1436:
1435:
1425:
1400:
1394:
1393:
1391:
1389:
1361:(7): 1257–1266.
1342:
1336:
1335:
1333:
1331:
1286:
1280:
1279:
1277:
1275:
1245:10.1038/348732a0
1216:
1210:
1209:
1207:
1205:
1184:
1173:10.1038/332411a0
1144:
1138:
1137:
1135:
1133:
1111:10.1038/348673a0
1086:
1077:
1071:
1070:
1068:
1066:
1051:
1045:
1044:
1042:
1040:
1031:. Archived from
1021:
1015:
1014:
1012:
1010:
995:
989:
988:
986:
984:
969:
963:
962:
960:
958:
949:. Archived from
939:
930:
929:
927:
925:
916:. Archived from
906:
895:
894:
892:
890:
881:. Archived from
874:
868:
867:
865:
863:
857:
851:. Archived from
846:
838:
827:
826:
824:
822:
813:. Archived from
803:
792:
791:
789:
787:
771:
695:Walter B. Cannon
664:Jacobæus Prize,
601:(encoded by the
583:forward genetics
522:Scripps Research
479:orphan receptors
453:vasoconstricting
391:orphan receptors
327:Kyoto University
238:
236:
230:
229:
207:Doctoral advisor
201:
170:Kyoto University
75:
71:
69:
57:
48:
36:
3424:
3423:
3419:
3418:
3417:
3415:
3414:
3413:
3319:
3318:
3317:
3312:
3303:Ellen Sidransky
3283:Michel Sadelain
3269:Emmanuel Mignot
3243:David Klenerman
3216:
3206:Catherine Dulac
3118:Harry F. Noller
3096:Karl Deisseroth
3082:Jennifer Doudna
3048:Michael N. Hall
3034:Bert Vogelstein
3030:Shinya Yamanaka
3026:Robert Weinberg
3022:Charles Sawyers
2980:
2957:Gilles Brassard
2937:Steven Weinberg
2919:Eric Adelberger
2829:Yōichirō Suzuki
2741:Saul Perlmutter
2707:Tejinder Virdee
2691:Stephen Hawking
2640:
2633:
2554:Simon Donaldson
2540:
2534:
2504:
2503:
2493:
2491:
2484:Christian Press
2477:
2476:
2472:
2462:
2460:
2447:
2446:
2442:
2432:
2430:
2417:
2416:
2412:
2402:
2400:
2387:
2386:
2382:
2372:
2370:
2361:
2360:
2356:
2346:
2344:
2340:
2328:(in Japanese).
2325:
2321:
2320:
2316:
2306:
2304:
2295:
2294:
2290:
2280:
2278:
2265:
2264:
2260:
2250:
2248:
2247:on May 26, 2022
2235:
2234:
2230:
2220:
2218:
2205:
2204:
2200:
2190:
2188:
2153:
2152:
2148:
2138:
2136:
2123:
2122:
2118:
2108:
2106:
2093:
2092:
2088:
2078:
2076:
2063:
2062:
2058:
2048:
2046:
2032:
2031:
2027:
2017:
2015:
2002:
2001:
1997:
1944:
1943:
1939:
1886:
1885:
1881:
1871:
1869:
1860:
1859:
1852:
1797:
1796:
1792:
1738:
1737:
1733:
1678:
1677:
1673:
1663:
1661:
1630:Nature Medicine
1621:
1620:
1616:
1571:"Narcolepsy in
1567:
1566:
1562:
1552:
1550:
1506:
1505:
1501:
1444:
1443:
1439:
1402:
1401:
1397:
1387:
1385:
1344:
1343:
1339:
1329:
1327:
1288:
1287:
1283:
1273:
1271:
1218:
1217:
1213:
1203:
1201:
1146:
1145:
1141:
1131:
1129:
1084:
1079:
1078:
1074:
1064:
1062:
1055:"Press release"
1053:
1052:
1048:
1038:
1036:
1023:
1022:
1018:
1008:
1006:
997:
996:
992:
982:
980:
971:
970:
966:
956:
954:
941:
940:
933:
923:
921:
908:
907:
898:
888:
886:
876:
875:
871:
861:
859:
855:
844:
840:
839:
830:
820:
818:
809:(in Japanese).
805:
804:
795:
785:
783:
776:""ねむけ"の謎を解明したい"
773:
772:
765:
760:
745:
740:
627:
611:phosphorylation
447:, which causes
415:
311:
279:
224:
199:
180:
176:
172:
141:
137:
133:
129:
125:
121:
79:
76:
73:
67:
65:
46:
41:
34:
17:
12:
11:
5:
3422:
3420:
3412:
3411:
3406:
3401:
3396:
3391:
3386:
3381:
3376:
3371:
3366:
3361:
3356:
3351:
3346:
3341:
3336:
3331:
3321:
3320:
3314:
3313:
3311:
3310:
3291:Paul Negulescu
3276:
3261:Demis Hassabis
3250:
3231:Katalin Karikó
3224:
3199:
3177:
3170:Xiaowei Zhuang
3155:
3144:Kazutoshi Mori
3133:
3111:
3089:
3063:
3037:
3010:Titia de Lange
2998:David Botstein
2990:
2988:
2982:
2981:
2979:
2978:
2968:
2950:
2940:
2930:
2916:
2910:
2899:Sergio Ferrara
2892:
2882:
2872:
2865:Lyman Page Jr.
2861:Norman Jarosik
2850:
2836:
2825:Takaaki Kajita
2782:
2781:project (2016)
2760:
2738:
2728:
2722:
2684:
2673:Nathan Seiberg
2669:Juan Maldacena
2645:
2643:
2635:
2634:
2632:
2631:
2625:
2619:
2613:
2607:
2601:
2595:
2592:James McKernan
2585:
2579:
2573:
2570:Richard Taylor
2550:
2548:
2542:
2541:
2535:
2533:
2532:
2525:
2518:
2510:
2502:
2501:
2470:
2440:
2410:
2380:
2354:
2330:Cabinet Office
2314:
2288:
2258:
2228:
2198:
2159:Oncology Times
2146:
2116:
2086:
2056:
2025:
1995:
1937:
1879:
1850:
1790:
1731:
1671:
1637:(9): 991–997.
1614:
1585:(4): 437–451.
1560:
1521:(3): 389–420.
1499:
1460:(1): 322–327.
1437:
1416:(4): 573–585.
1395:
1337:
1303:(3): 473–485.
1281:
1211:
1139:
1072:
1046:
1016:
990:
964:
931:
896:
869:
828:
793:
762:
761:
759:
756:
744:
741:
739:
738:
732:
726:
720:
714:
708:
702:
692:
682:
677:Member of the
675:
669:
662:
655:
648:
641:
635:
628:
626:
623:
595:electromyogram
461:for endothelin
414:
411:
369:full professor
310:
307:
278:
275:
217:
216:
213:
212:
209:
203:
202:
191:
185:
184:
167:
163:
162:
157:
153:
152:
146:
145:
116:
112:
111:
101:
97:
96:
93:
89:
88:
85:
81:
80:
77:
63:
59:
58:
50:
49:
43:
42:
39:
15:
13:
10:
9:
6:
4:
3:
2:
3421:
3410:
3407:
3405:
3402:
3400:
3397:
3395:
3392:
3390:
3387:
3385:
3382:
3380:
3377:
3375:
3372:
3370:
3367:
3365:
3362:
3360:
3357:
3355:
3352:
3350:
3347:
3345:
3342:
3340:
3337:
3335:
3334:Living people
3332:
3330:
3327:
3326:
3324:
3308:
3304:
3300:
3299:Thomas Gasser
3296:
3292:
3288:
3287:Sabine Hadida
3284:
3280:
3277:
3274:
3270:
3266:
3262:
3258:
3254:
3251:
3248:
3244:
3240:
3236:
3235:Drew Weissman
3232:
3228:
3225:
3220:
3215:
3211:
3207:
3203:
3200:
3197:
3193:
3189:
3185:
3181:
3178:
3175:
3171:
3167:
3166:Angelika Amon
3163:
3159:
3156:
3153:
3149:
3145:
3141:
3137:
3134:
3131:
3127:
3123:
3122:Roeland Nusse
3119:
3115:
3112:
3109:
3105:
3101:
3097:
3093:
3092:Edward Boyden
3090:
3087:
3083:
3079:
3075:
3074:Victor Ambros
3071:
3067:
3064:
3061:
3057:
3053:
3049:
3045:
3044:Mahlon DeLong
3041:
3038:
3035:
3031:
3027:
3023:
3019:
3015:
3011:
3007:
3003:
2999:
2995:
2992:
2991:
2989:
2987:
2986:Life sciences
2983:
2976:
2972:
2969:
2966:
2965:Peter W. Shor
2962:
2961:David Deutsch
2958:
2954:
2951:
2948:
2944:
2941:
2938:
2934:
2931:
2928:
2927:Blayne Heckel
2924:
2920:
2917:
2914:
2911:
2908:
2904:
2900:
2896:
2893:
2890:
2886:
2883:
2880:
2876:
2873:
2870:
2869:David Spergel
2866:
2862:
2858:
2854:
2851:
2848:
2844:
2840:
2837:
2834:
2830:
2826:
2822:
2818:
2814:
2810:
2806:
2802:
2798:
2797:Atsuto Suzuki
2794:
2793:Daya Bay team
2790:
2786:
2783:
2780:
2776:
2772:
2768:
2767:Ronald Drever
2764:
2761:
2758:
2754:
2750:
2749:Brian Schmidt
2746:
2742:
2739:
2736:
2732:
2731:Michael Green
2729:
2726:
2723:
2720:
2716:
2712:
2711:Guido Tonelli
2708:
2704:
2700:
2696:
2692:
2688:
2685:
2682:
2681:Edward Witten
2678:
2674:
2670:
2666:
2662:
2658:
2657:Alexei Kitaev
2654:
2650:
2647:
2646:
2644:
2642:
2636:
2629:
2628:Simon Brendle
2626:
2623:
2620:
2617:
2614:
2611:
2610:Martin Hairer
2608:
2605:
2602:
2599:
2596:
2593:
2589:
2586:
2583:
2582:Jean Bourgain
2580:
2577:
2574:
2571:
2567:
2563:
2559:
2555:
2552:
2551:
2549:
2547:
2543:
2538:
2531:
2526:
2524:
2519:
2517:
2512:
2511:
2508:
2489:
2485:
2481:
2474:
2471:
2463:September 19,
2458:
2454:
2450:
2444:
2441:
2428:
2424:
2420:
2414:
2411:
2398:
2394:
2390:
2389:"令和元年度 文化功労者"
2384:
2381:
2368:
2364:
2358:
2355:
2339:
2335:
2331:
2324:
2318:
2315:
2302:
2298:
2292:
2289:
2276:
2272:
2268:
2262:
2259:
2246:
2242:
2238:
2232:
2229:
2216:
2212:
2208:
2202:
2199:
2186:
2182:
2178:
2173:
2168:
2164:
2160:
2156:
2150:
2147:
2134:
2130:
2126:
2120:
2117:
2104:
2100:
2096:
2090:
2087:
2074:
2070:
2066:
2060:
2057:
2044:
2040:
2036:
2029:
2026:
2013:
2009:
2005:
1999:
1996:
1991:
1987:
1982:
1977:
1973:
1969:
1965:
1961:
1957:
1953:
1949:
1941:
1938:
1933:
1929:
1924:
1919:
1915:
1911:
1907:
1903:
1899:
1895:
1891:
1883:
1880:
1867:
1863:
1857:
1855:
1851:
1846:
1842:
1837:
1832:
1827:
1822:
1818:
1814:
1810:
1806:
1802:
1794:
1791:
1786:
1782:
1777:
1772:
1767:
1762:
1758:
1754:
1750:
1746:
1742:
1735:
1732:
1727:
1723:
1718:
1713:
1708:
1703:
1699:
1695:
1691:
1687:
1683:
1675:
1672:
1660:
1656:
1652:
1648:
1644:
1643:10.1038/79690
1640:
1636:
1632:
1631:
1626:
1618:
1615:
1610:
1606:
1602:
1598:
1593:
1588:
1584:
1580:
1576:
1574:
1564:
1561:
1548:
1544:
1540:
1536:
1532:
1528:
1524:
1520:
1516:
1515:
1510:
1503:
1500:
1495:
1491:
1486:
1481:
1476:
1471:
1467:
1463:
1459:
1455:
1454:
1449:
1441:
1438:
1433:
1429:
1424:
1419:
1415:
1411:
1407:
1399:
1396:
1384:
1380:
1376:
1372:
1368:
1364:
1360:
1356:
1352:
1348:
1341:
1338:
1326:
1322:
1318:
1314:
1310:
1306:
1302:
1298:
1297:
1292:
1285:
1282:
1270:
1266:
1262:
1258:
1254:
1250:
1246:
1242:
1238:
1234:
1230:
1226:
1222:
1215:
1212:
1200:
1196:
1192:
1188:
1183:
1178:
1174:
1170:
1166:
1162:
1158:
1154:
1150:
1143:
1140:
1128:
1124:
1120:
1116:
1112:
1108:
1104:
1100:
1097:(6303): 673.
1096:
1092:
1091:
1083:
1076:
1073:
1060:
1056:
1050:
1047:
1034:
1030:
1026:
1020:
1017:
1004:
1000:
994:
991:
978:
974:
968:
965:
952:
948:
944:
938:
936:
932:
919:
915:
911:
905:
903:
901:
897:
884:
880:
873:
870:
854:
850:
843:
837:
835:
833:
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743:Personal life
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685:Ulf von Euler
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657:Amgen Award,
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24:
23:personal name
19:
3272:
3247:Pascal Mayer
3192:David Julius
3174:Zhijian Chen
3140:Peter Walter
3136:Joanne Chory
3108:Svante Pääbo
3006:Hans Clevers
2932:
2894:
2885:Charles Kane
2874:
2857:Gary Hinshaw
2775:Rainer Weiss
2762:
2721:(LHC) (2013)
2686:
2665:Andrei Linde
2492:. Retrieved
2488:the original
2483:
2473:
2461:. Retrieved
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2443:
2431:. Retrieved
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2347:November 22,
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2317:
2307:November 22,
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2281:November 20,
2279:. Retrieved
2275:the original
2271:Sleep Review
2270:
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2221:November 22,
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2191:November 20,
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2079:November 17,
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2028:
2018:November 17,
2016:. Retrieved
2012:the original
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993:
983:November 15,
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780:the original
746:
606:
602:
580:
574:(FFA3), and
566:(NPBW1) and
557:
542:
525:
510:hypothalamus
504:" after the
476:
465:
449:vasodilation
433:nitric oxide
426:neuropeptide
416:
395:
377:
347:, both 1985
334:
319:Pharmacology
312:
280:
252:neuropeptide
221:
220:
211:Tomoh Masaki
193:
166:Institutions
149:
78:Tokyo, Japan
72:May 25, 1960
26:
18:
3329:1960 births
3265:John Jumper
3217: [
3202:David Baker
3148:Kim Nasmyth
3130:Huda Zoghbi
3104:Helen Hobbs
3078:Gary Ruvkun
3018:Eric Lander
2889:Eugene Mele
2847:Cumrun Vafa
2835:team (2016)
2789:Kam-Biu Luk
2785:Yifang Wang
2695:Peter Jenni
2639:Fundamental
2566:Terence Tao
2562:Jacob Lurie
2546:Mathematics
2494:November 4,
2433:November 3,
2403:January 18,
2373:January 29,
1388:November 9,
1330:November 9,
1274:November 9,
1204:November 8,
1132:November 8,
1065:November 8,
1039:November 3,
957:November 6,
924:November 6,
862:November 4,
821:November 4,
786:November 4,
711:Asahi Prize
619:sleep cycle
547:the orexin
545:knocked out
353:cholesterol
131:Asahi Prize
92:Citizenship
84:Nationality
3323:Categories
3100:John Hardy
2971:John Cardy
2771:Kip Thorne
2753:Adam Riess
2717:(CMS) and
2677:Ashoke Sen
2604:Alex Eskin
758:References
553:narcolepsy
534:transcript
483:endogenous
422:endothelin
384:endogenous
283:electrical
259:narcolepsy
248:endothelin
68:1960-05-25
3279:Carl June
3210:Dennis Lo
2719:Lyn Evans
2701:(ATLAS),
2653:Alan Guth
2539:laureates
2181:220570423
1253:2241/1311
1182:2241/1639
752:Christian
687:lecture,
621:in mice.
587:mutations
578:(QRFPR).
570:(NPBW2),
100:Education
2831:and the
2819:and the
2807:and the
2799:and the
2791:and the
2576:Ian Agol
1990:29899451
1932:27806374
1845:16648250
1785:14722361
1726:12719537
1659:18076282
1651:10973318
1609:89799178
1601:10481909
1535:22759794
1383:24894649
1349:(1994).
774:餌取, 章男.
599:KIAA0999
458:receptor
424:and the
413:Research
250:and the
87:American
2933:Special
2895:Special
2875:Special
2801:KamLAND
2763:Special
2687:Special
2641:physics
2251:May 26,
1981:6350790
1960:Bibcode
1923:6076225
1902:Bibcode
1836:1464357
1813:Bibcode
1753:Bibcode
1694:Bibcode
1543:2038246
1494:9419374
1462:Bibcode
1432:9491897
1375:8001158
1325:7872049
1317:8062389
1269:4249387
1261:2175397
1233:Bibcode
1199:4308549
1191:2451132
1161:Bibcode
1127:4351182
1119:2175394
1099:Bibcode
749:Baptist
538:peptide
486:ligands
443:around
419:hormone
387:ligands
321:of the
245:hormone
3309:(2024)
3275:(2023)
3249:(2022)
3223:(2021)
3198:(2020)
3176:(2019)
3154:(2018)
3132:(2017)
3110:(2016)
3088:(2015)
3062:(2014)
3036:(2013)
2977:(2024)
2967:(2023)
2949:(2022)
2947:Jun Ye
2939:(2021)
2929:(2021)
2915:(2020)
2909:(2019)
2891:(2019)
2881:(2018)
2871:(2018)
2849:(2017)
2823:team,
2815:team,
2803:team,
2759:(2015)
2737:(2014)
2727:(2013)
2683:(2012)
2630:(2024)
2624:(2023)
2618:(2022)
2612:(2021)
2606:(2020)
2600:(2019)
2594:(2018)
2584:(2017)
2578:(2016)
2572:(2015)
2179:
1988:
1978:
1952:Nature
1930:
1920:
1894:Nature
1843:
1833:
1783:
1776:327148
1773:
1724:
1717:156358
1714:
1657:
1649:
1607:
1599:
1573:orexin
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1492:
1482:
1430:
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1373:
1323:
1315:
1267:
1259:
1225:Nature
1197:
1189:
1153:Nature
1125:
1117:
1090:Nature
737:(2023)
731:(2023)
725:(2019)
719:(2018)
713:(2017)
707:(2016)
701:(2015)
691:(2012)
681:(2003)
674:(2003)
668:(2001)
661:(1999)
654:(1998)
647:(1998)
640:(1997)
634:(1998)
576:GPR103
502:orexin
429:orexin
309:Career
255:orexin
200:(1988)
198:
189:Thesis
156:Fields
115:Awards
110:, PhD)
3221:]
2341:(PDF)
2326:(PDF)
2177:S2CID
1655:S2CID
1605:S2CID
1539:S2CID
1485:18213
1379:S2CID
1321:S2CID
1265:S2CID
1195:S2CID
1123:S2CID
1085:(PDF)
856:(PDF)
845:(PDF)
607:Nalcn
572:GPR41
560:sleep
520:(now
506:Greek
337:Kyoto
289:, an
228:柳沢 正史
47:柳沢 正史
3305:and
3245:and
3160:and
3106:and
3084:and
3058:and
3032:and
2973:and
2945:and
2925:and
2887:and
2827:and
2779:LIGO
2733:and
2568:and
2496:2022
2465:2023
2435:2022
2405:2022
2375:2018
2349:2022
2309:2022
2283:2022
2253:2022
2223:2022
2193:2022
2141:2022
2111:2022
2081:2022
2051:2022
2020:2022
1986:PMID
1928:PMID
1874:2022
1841:PMID
1781:PMID
1722:PMID
1666:2022
1647:PMID
1597:PMID
1579:Cell
1555:2022
1531:PMID
1490:PMID
1428:PMID
1410:Cell
1390:2022
1371:PMID
1355:Cell
1332:2022
1313:PMID
1296:Cell
1276:2022
1257:PMID
1206:2022
1187:PMID
1134:2022
1115:PMID
1067:2022
1041:2022
1011:2022
985:2022
959:2022
926:2022
891:2022
864:2022
823:2022
788:2022
613:and
603:Sik3
593:and
568:GPR8
564:GPR7
549:gene
532:and
530:gene
526:HCRT
514:mice
389:for
343:and
285:and
62:Born
2813:T2K
2809:K2K
2167:doi
1976:PMC
1968:doi
1956:558
1918:PMC
1910:doi
1898:539
1831:PMC
1821:doi
1809:103
1771:PMC
1761:doi
1749:101
1712:PMC
1702:doi
1690:100
1639:doi
1587:doi
1523:doi
1480:PMC
1470:doi
1418:doi
1363:doi
1305:doi
1249:hdl
1241:doi
1229:348
1177:hdl
1169:doi
1157:332
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