260:
272:
248:
55:
387:, are given prior to surgery to protect against the effects of histamine released from the tumor. Wide margins (two to three centimeters) are required because of the tendency for the tumor cells to be spread out around the tumor. If complete removal is not possible due to the size or location, additional treatment, such as
456:
carried a worse prognosis have been discounted. Tumors that have spread to the lymph nodes or other parts of the body have a poor prognosis. Any dog showing symptoms of mastocytosis or with a grade III tumor has a poor prognosis. Dogs of the Boxer breed have a better than average prognosis because of
1094:
Séguin B, Besancon M, McCallan J, Dewe L, Tenwolde M, Wong E, Kent M (2006). "Recurrence rate, clinical outcome, and cellular proliferation indices as prognostic indicators after incomplete surgical excision of cutaneous grade II mast cell tumors: 28 dogs (1994–2002)".
143:
is rarely seen in young dogs and cats, while mast cell tumors are usually skin tumors in older dogs and cats. Although not always malignant, they do have the potential to be. Up to 25 percent of skin tumors in dogs are mast cell tumors, with a similar number in cats.
960:"Multi-center, Placebo-controlled, Double-blind, Randomized Study of Oral Toceranib Phosphate (SU11654), a Receptor Tyrosine Kinase Inhibitor, for the Treatment of Dogs with Recurrent (Either Local or Distant) Mast Cell Tumor Following Surgical Excision"
1667:
1648:
460:
Mast cell tumors do not necessarily follow the histological prognosis. Further prognostic information can be provided by AgNOR stain of histological or cytological specimen. Even then, there is a risk of unpredictable behavior.
157:
When mastocytomas affect humans, they are typically found in skin. They usually occur as a single lesion on the trunk or wrist. Although it is rare, mastocytomas are sometimes found in the lung. It can also affect children.
481:, mast cell tumors are rare. They tend to be solitary and benign in pigs and multiple and malignant in cattle. Mast cell tumors are found in the skin of cattle most commonly, but these may be metastases from tumors of the
999:
Dubreuil P, Letard S, Ciufolini M, Gros L, Humbert M, Castéran N, Borge L, Hajem B, Lermet A, Sippl W, Voisset E, Arock M, Auclair C, Leventhal PS, Mansfield CD, Moussy A, Hermine O (September 2009).
1130:
Sfiligoi G, Rassnick K, Scarlett J, Northrup N, Gieger T (2005). "Outcome of dogs with mast cell tumors in the inguinal or perineal region versus other cutaneous locations: 124 cases (1990–2001)".
2381:
2516:
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involvement is more common in cats than in dogs; 50 percent of cases in dogs primarily involved the spleen or intestines. Gastrointestinal mast cell tumors are most commonly found in the
1167:"Evaluation of prognostic factors associated with outcome in dogs with multiple cutaneous mast cell tumors treated with surgery with and without adjuvant treatment: 54 cases (1998–2004)"
3051:
627:
as an alternative to surgery. The prognosis for solitary skin tumors is good, but guarded for tumors in other organs. Histological grading of tumors has little bearing on prognosis.
1682:
3071:
1861:
497:
Mast cell tumors mainly occur in older adult dogs, but have been known to occur on rare occasions in puppies. The following breeds are commonly affected by mast cell tumors:
1206:
Scase T, Edwards D, Miller J, Henley W, Smith K, Blunden A, Murphy S (2006). "Canine mast cell tumors: correlation of apoptosis and proliferation markers with prognosis".
590:
are at an increased risk for the histiocytic type, although the mast cell type is the most common in all cats and is considered to be benign when confined to the skin.
2302:
2012:
1965:
1866:
2509:
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the relatively benign behavior of their mast cell tumors. Multiple tumors that are treated similarly to solitary tumors do not seem to have a worse prognosis.
1790:
434:
2161:
1871:
691:
Johnson T, Schulman F, Lipscomb T, Yantis L (2002). "Histopathology and biologic behavior of pleomorphic cutaneous mast cell tumors in fifteen cats".
1082:
2502:
2282:
259:
291:
of the tumor will typically show a large number of mast cells. This is sufficient to make the diagnosis of a mast cell tumor, although poorly
186:, or itchy. They are usually solitary, but in about six percent of cases, there are multiple mast cell tumors (especially in Boxers and Pugs).
218:
1938:
209:, which is the spread of mast cells throughout the body. Release of a large amount of histamine at one time can result in ulceration of the
2872:
2719:
2447:
473:. They usually occur as benign, solitary masses on the skin of the head, neck, trunk, and legs. Mineralization of the tumor is common. In
2555:
2297:
89:
620:
Diagnosis and treatment are similar to that of the dog. Cases involving difficult to remove or multiple tumors have responded well to
295:
mast cells may have few granules and thus are difficult to identify. The granules of the mast cell stain blue to dark purple with a
2632:
942:
750:
3123:
2022:
1783:
247:
448:. One study showed about 23 percent of incompletely removed grade II tumors recurred locally. Any mast cell tumor found in the
2891:
2600:
2287:
2198:
2027:
765:
271:
193:, and prolonged local hemorrhage. In rare cases, a highly malignant tumor is present, and signs may include loss of appetite,
2667:
2652:
2647:
2371:
1594:
Molander-McCrary H, Henry C, Potter K, Tyler J, Buss M (1998). "Cutaneous mast cell tumors in cats: 32 cases (1991–1994)".
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2000:
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Stage IV – a tumor with metastasis to the spleen, liver, or bone marrow, or with the presence of mast cells in the blood
2714:
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2181:
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2117:
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GarcĂa
Iglesias F, Sánchez GarcĂa AM, GarcĂa Lara GM. Mastocitoma solitario. Rev Pediatr Aten Primaria. 2014;16:35-7
2994:
2570:
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2143:
551:
506:
136:
864:
Vandis, Maria; Knoll, Joyce S. (March 2007). "Cytological examination of a cutaneous mast cell tumor in a boxer".
357:
Stage III - multiple skin tumors or a large tumor invading deep to the skin with or without lymph node involvement
3118:
3006:
2787:
2191:
2082:
1555:"Evaluation of strontium 90 irradiation in treatment of cutaneous mast cell tumors in cats: 35 cases (1992–2002)"
326:
Grade II – intermediately differentiated cells with potential for local invasion and moderate metastatic behavior
3202:
2657:
2267:
2233:
1933:
1803:
1690:
1411:"Characterisation of the signalment, clinical and survival characteristics of 41 cats with mast cell neoplasia"
649:"Use of a reverse saphenous skin flap for the excision of a grade II mast cell tumor on the hind limb of a dog"
426:
292:
288:
189:
Manipulation of the tumor may result in redness and swelling from release of mast cell granules, also known as
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Two types of mast cell tumors have been identified in cats, a mast cell type similar to dogs and a
571:
28:
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452:, paw, or on the muzzle has a guarded prognosis. Previous beliefs that tumors in the groin or
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skin mass. Most mast cell tumors are small, raised lumps on the skin. They may be hairless,
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Mast cell tumors of the skin are usually located on the head or trunk. Gastrointestinal and
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54:
1768:
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Takahashi T, Kadosawa T, Nagase M, Matsunaga S, Mochizuki M, Nishimura R, Sasaki N (2000).
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124:
96:. It is found in humans and many animal species; it also can refer to an accumulation or
3113:
738:
1437:
1410:
1251:
Cole R, Chesen A, Pool R, Watkins J (2007). "Imaging diagnosis—equine mast cell tumor".
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Proceedings of the 30th World
Congress of the World Small Animal Veterinary Association
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371:, or lymph node, bone marrow, or organ biopsies may be necessary to stage the disease.
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648:
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2047:
1979:
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112:
1454:
1001:"Masitinib (AB1010), a potent and selective tyrosine kinase inhibitor targeting KIT"
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Grade I – well differentiated and mature cells with a low potential for metastasis
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Stage II - a single skin tumor with spread to lymph nodes in the surrounding area
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Grade III – undifferentiated, immature cells with a high potential for metastasis
3148:
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of the tumor. The grade depends on how well the mast cells are differentiated,
238:
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1427:
1386:
1369:
737:
Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson JL, Loscalzo J, eds. (2013).
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type that appears as subcutaneous nodules and may resolve spontaneously. Young
17:
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485:. Other sites in cattle include the spleen, muscle, gastrointestinal tract,
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Removal of the mast cell tumor through surgery is the treatment of choice.
174:-like nodule to a soft subcutaneous lump (similar on palpation to a benign
1615:
1395:
1354:
444:
Grade I or II mast cell tumors that can be completely removed have a good
2532:
2320:
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1912:
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as 'the great pretenders' because their appearance can be varied, from a
72:
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activity, location within the skin, invasiveness, and the presence of
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1811:
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482:
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300:
230:
202:
175:
1165:
Mullins M, Dernell W, Withrow S, Ehrhart E, Thamm D, Lana S (2006).
337:
in assigning grades to mast cell tumors due to imprecise criteria.
2938:
2212:
1536:
Compendium on
Continuing Education for the Practicing Veterinarian
470:
364:
226:
171:
2498:
1772:
958:
London CA, Malpas PB, Wood-Follis SL, et al. (June 2009).
415:
are common chemotherapy agents used to treat mast cell tumors.
609:. It is the third most common intestinal tumor in cats, after
561:
474:
341:
333:
However, there is a significant amount of discordance between
2382:
Adult type of generalized eruption of cutaneous mastocytosis
1470:"Visceral mast cell tumors in dogs: 10 cases (1982–1997)"
1220:
10.1892/0891-6640(2006)20[151:CMCTCO]2.0.CO;2
1370:"The occurrence of mast cell tumors in young Shar-Peis"
299:, and the cells are medium-sized. However, a surgical
3052:
Multiple cutaneous and uterine leiomyomatosis syndrome
1534:
Moriello, Karen A. (April 2007). "Clinical
Snapshot".
399:
is often used to shrink the remaining tumor portion.
1630:
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2009:
1987:
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1885:
1843:
1834:
1825:
1810:
1716:
1634:
66:
44:
39:
930:
885:"Morphometry of canine cutaneous mast cell tumors"
407:, protect against stomach damage from histamine.
205:. The presence of these signs usually indicates
2303:Refractory cytopenia with multilineage dysplasia
1553:Turrel J, Farrelly J, Page R, McEntee M (2006).
1083:CBS News FDA Approves First-Ever Dog Cancer Drug
924:
922:
920:
429:inhibitors, are used in the treatment of canine
348:Stage I - a single skin tumor with no spread to
469:Mast cell tumors are an uncommon occurrence in
1966:Accelerated phase chronic myelogenous leukemia
2510:
1784:
8:
1288:"Congenital mastocytomas in a Holstein calf"
883:Strefezzi R, Xavier J, CatĂŁo-Dias J (2003).
340:The disease is also staged according to the
166:Mast cell tumors are known among veterinary
732:
730:
433:tumors. Both were recently approved by the
265:Mast cell tumor on the inner thigh of a dog
2926:
2584:
2575:
2517:
2503:
2495:
2431:
2325:
2217:
2175:
2166:
2101:
2066:
1984:
1917:
1840:
1831:
1822:
1791:
1777:
1769:
1631:
743:Harrison's principles of internal medicine
217:(present in up to 25 percent of cases) or
53:
36:
1570:
1485:
1436:
1426:
1385:
1344:
1303:
1227:
1182:
1070:"KINAVET is Now Available from VetSource"
1034:
1024:
975:
900:
664:
745:(18th ed.). New York: McGraw-Hill.
686:
684:
111:of the body as normal components of the
2283:Refractory anemia with excess of blasts
872:(3). Advanstar Communications: 165–168.
809:
807:
805:
803:
801:
775:
773:
636:
243:
1542:(4). Veterinary Learning Systems: 204.
937:(1st ed.). Williams and Wilkins.
739:"Less Common Hematologic Malignancies"
642:
640:
219:disseminated intravascular coagulation
139:, and other substances. Disseminated
107:and are normally found throughout the
100:of mast cells that resembles a tumor.
1329:"Mastocytoma in a cow: a case report"
123:. Mast cells also respond to tissue
7:
2448:Acute panmyelosis with myelofibrosis
782:"Cutaneous Mast Cell Tumors in Dogs"
253:Mast cell tumor on the side of a dog
2556:Desmoplastic small-round-cell tumor
2298:Paroxysmal nocturnal hemoglobinuria
1109:10.1111/j.1939-1676.2006.tb01808.x
25:
2633:Aggressive infantile fibromatosis
435:U.S. Food and Drug Administration
225:does occur, it is usually to the
3124:Clear-cell sarcoma of the kidney
2023:Juvenile myelomonocytic leukemia
1265:10.1111/j.1740-8261.2007.00200.x
270:
258:
246:
2892:Intradermal spindle cell lipoma
2601:Dermatofibrosarcoma protuberans
2288:Chromosome 5q deletion syndrome
2199:Acute megakaryoblastic leukemia
2028:Chronic myelomonocytic leukemia
1939:Myeloid dendritic cell leukemia
605:, but can also be found in the
2720:Malignant fibrous histiocytoma
2668:Infantile digital fibromatosis
2653:Familial myxovascular fibromas
2648:Diffuse infantile fibromatosis
2372:Diffuse cutaneous mastocytosis
103:Mast cells originate from the
27:For mastocytomas in dogs, see
1:
2766:Superficial acral fibromyxoma
2673:Juvenile hyaline fibromatosis
2140:Chronic eosinophilic leukemia
1899:Chronic neutrophilic leukemia
1409:Litster A, Sorenmo K (2006).
977:10.1158/1078-0432.CCR-08-1860
929:Morrison, Wallace B. (1998).
3067:Solitary cutaneous leiomyoma
3057:Multiple cutaneous leiomyoma
2778:Ossifying fibromyxoid tumour
2480:Biphenotypic acute leukaemia
2415:Xanthelasmoidal mastocytosis
1510:"Gastrointestinal Neoplasia"
1286:Smith B, Phillips L (2001).
1026:10.1371/journal.pone.0007258
815:"Cutaneous Mast Cell Tumors"
2715:Benign fibrous histiocytoma
1857:Acute myeloblastic leukemia
1748:from The Pet Health Library
1514:The Merck Veterinary Manual
1144:10.2460/javma.2005.226.1368
844:The Merck Veterinary Manual
819:The Merck Veterinary Manual
119:, they are associated with
3219:
2995:Embryonal rhabdomyosarcoma
2571:Connective tissue neoplasm
2377:Erythrodermic mastocytosis
2144:Hypereosinophilic syndrome
1487:10.2460/javma.2000.216.222
1428:10.1016/j.jfms.2005.12.005
1387:10.1177/104063879500700311
1327:Ames T, O'Leary T (1984).
780:Moore, Anthony S. (2005).
552:German shorthaired pointer
507:Staffordshire bull terrier
437:(FDA) as dog-specific anti
277:Mast cell tumor of the paw
137:platelet-activating factor
26:
3119:Malignant rhabdoid tumour
3086:Complex mixed and stromal
3015:
3007:Alveolar rhabdomyosarcoma
2192:Essential thrombocythemia
1608:10.5326/15473317-34-4-281
840:"Common Cytology Results"
61:
52:
2658:Fibroma of tendon sheath
1804:hematological malignancy
1762:Mast Cell Tumors in Cats
1754:Mast Cell Tumors in Dogs
427:receptor tyrosine kinase
303:is required to find the
289:needle aspiration biopsy
62:Mast cell tumor cytology
2688:Oral submucous fibrosis
2628:Aggressive fibromatosis
2544:Not otherwise specified
1961:Philadelphia chromosome
1572:10.2460/javma.228.6.898
933:Cancer in Dogs and Cats
375:Treatment and prognosis
335:veterinary pathologists
2730:Solitary fibrous tumor
2725:Atypical fibroxanthoma
1764:from Pet Cancer Center
1756:from Pet Cancer Center
1184:10.2460/javma.228.1.91
450:gastrointestinal tract
3104:Mixed MĂĽllerian tumor
2475:Primary myelofibrosis
2407:Systemic mastocytosis
2352:Systemic mastocytosis
1253:Vet Radiol Ultrasound
3109:Mesoblastic nephroma
2678:Plantar fibromatosis
2606:Desmoplastic fibroma
2397:Solitary mastocytoma
2387:Urticaria pigmentosa
2293:Sideroblastic anemia
1596:J Am Anim Hosp Assoc
395:, may be necessary.
3099:Pleomorphic adenoma
2907:Spindle cell lipoma
2707:histiocytic sarcoma
2683:Pleomorphic fibroma
2643:Collagenous fibroma
2638:Aponeurotic fibroma
2551:Soft-tissue sarcoma
1017:2009PLoSO...4.7258D
902:10.1354/vp.40-3-268
866:Veterinary Medicine
705:10.1354/vp.39-4-452
572:Rhodesian ridgeback
131:contain histamine,
29:Mastocytoma in dogs
3062:Neural fibrolipoma
3037:Angiolipoleiomyoma
3000:Sarcoma botryoides
2897:Pleomorphic lipoma
2866:Myxoid liposarcoma
2830:Clear-cell sarcoma
2663:Fibromatosis colli
2342:Mast cell leukemia
2234:Erythroleukemia/M6
2118:Acute eosinophilic
1717:External resources
1559:J Am Vet Med Assoc
1474:J Am Vet Med Assoc
1374:J Vet Diagn Invest
1171:J Am Vet Med Assoc
1132:J Am Vet Med Assoc
542:Labrador retriever
148:Signs and symptoms
121:allergic reactions
115:. As they release
3170:
3169:
3162:Adenomatoid tumor
3134:Pancreatoblastoma
3080:
3079:
3042:Genital leiomyoma
2902:Lipoblastomatosis
2838:
2837:
2738:
2737:
2693:Pachydermodactyly
2492:
2491:
2488:
2487:
2423:
2422:
2392:Mast cell sarcoma
2347:Mast cell sarcoma
2315:
2314:
2311:
2310:
2278:Refractory anemia
2256:Polycythemia vera
2207:
2206:
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2055:
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2035:
1974:
1973:
1907:
1906:
1740:
1739:
1415:J Feline Med Surg
1368:Miller D (1995).
647:Brière C (2002).
389:radiation therapy
109:connective tissue
78:
77:
34:Medical condition
16:(Redirected from
3210:
2991:rhabdomyosarcoma
2980:
2956:
2932:
2927:
2887:Chondroid lipoma
2825:Synovial sarcoma
2761:Cutaneous myxoma
2585:
2576:
2519:
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2505:
2496:
2468:
2441:
2432:
2428:Multiple/unknown
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2083:Acute basophilic
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1746:Mast Cell Tumors
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1097:J Vet Intern Med
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1058:FDA NEWS RELEASE
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668:
644:
599:muscularis layer
557:Scottish terrier
537:Golden retriever
297:Romanowsky stain
274:
262:
250:
90:round-cell tumor
57:
37:
21:
3218:
3217:
3213:
3212:
3211:
3209:
3208:
3207:
3203:Bovine diseases
3173:
3172:
3171:
3166:
3143:
3076:
3011:
2978:Skeletal muscle
2976:
2971:
2952:
2947:
2930:
2916:
2834:
2810:
2806:Phyllodes tumor
2788:Fibroepithelial
2782:
2734:
2697:
2610:
2565:
2539:
2523:
2493:
2484:
2462:
2457:
2453:Myeloid sarcoma
2435:
2419:
2406:
2401:
2361:
2356:
2329:
2307:
2265:
2260:
2243:
2238:
2221:
2203:
2179:
2148:
2127:
2122:
2105:
2087:
2070:
2052:
2032:
2010:
2005:
1988:
1970:
1948:
1943:
1921:
1903:
1886:
1881:
1844:
1815:
1806:
1797:
1741:
1736:
1735:
1712:
1711:
1643:
1629:
1624:
1623:
1593:
1592:
1588:
1552:
1551:
1547:
1533:
1532:
1528:
1519:
1517:
1508:
1507:
1503:
1467:
1466:
1462:
1408:
1407:
1403:
1367:
1366:
1362:
1326:
1325:
1321:
1285:
1284:
1280:
1250:
1249:
1245:
1205:
1204:
1200:
1164:
1163:
1159:
1129:
1128:
1124:
1093:
1092:
1088:
1081:
1077:
1068:
1067:
1063:
1056:
1052:
998:
997:
993:
970:(11): 3856–65.
964:Clin Cancer Res
957:
956:
952:
945:
928:
927:
918:
882:
881:
877:
863:
862:
858:
849:
847:
838:
837:
833:
824:
822:
813:
812:
799:
790:
788:
779:
778:
771:
764:
760:
753:
736:
735:
728:
690:
689:
682:
646:
645:
638:
633:
607:large intestine
603:small intestine
580:
495:
467:
385:diphenhydramine
377:
285:
278:
275:
266:
263:
254:
251:
164:
155:
150:
86:mast cell tumor
48:Mast cell tumor
35:
32:
23:
22:
18:Mast cell tumor
15:
12:
11:
5:
3216:
3214:
3206:
3205:
3200:
3198:Swine diseases
3195:
3193:Horse diseases
3190:
3185:
3175:
3174:
3168:
3167:
3165:
3164:
3159:
3153:
3151:
3145:
3144:
3142:
3141:
3139:Carcinosarcoma
3136:
3131:
3129:Hepatoblastoma
3126:
3121:
3116:
3111:
3106:
3101:
3096:
3090:
3088:
3082:
3081:
3078:
3077:
3075:
3074:
3069:
3064:
3059:
3054:
3049:
3047:Leiomyosarcoma
3044:
3039:
3034:
3032:Angioleiomyoma
3029:
3028:
3027:
3016:
3013:
3012:
3010:
3009:
3004:
3003:
3002:
2983:
2981:
2973:
2972:
2970:
2969:
2967:leiomyosarcoma
2959:
2957:
2949:
2948:
2946:
2945:
2935:
2933:
2924:
2918:
2917:
2915:
2914:
2909:
2904:
2899:
2894:
2889:
2883:
2882:
2881:
2880:
2878:Angiomyolipoma
2870:
2869:
2868:
2863:
2848:
2846:
2840:
2839:
2836:
2835:
2833:
2832:
2827:
2821:
2819:
2812:
2811:
2809:
2808:
2803:
2798:
2796:Brenner tumour
2792:
2790:
2784:
2783:
2781:
2780:
2775:
2770:
2769:
2768:
2763:
2748:
2746:
2740:
2739:
2736:
2735:
2733:
2732:
2727:
2722:
2717:
2711:
2709:
2699:
2698:
2696:
2695:
2690:
2685:
2680:
2675:
2670:
2665:
2660:
2655:
2650:
2645:
2640:
2635:
2630:
2624:
2622:
2612:
2611:
2609:
2608:
2603:
2597:
2595:
2582:
2573:
2567:
2566:
2564:
2563:
2558:
2553:
2547:
2545:
2541:
2540:
2524:
2522:
2521:
2514:
2507:
2499:
2490:
2489:
2486:
2485:
2483:
2482:
2477:
2471:
2469:
2459:
2458:
2456:
2455:
2450:
2444:
2442:
2429:
2425:
2424:
2421:
2420:
2418:
2417:
2411:
2409:
2403:
2402:
2400:
2399:
2394:
2389:
2384:
2379:
2374:
2368:
2366:
2358:
2357:
2355:
2354:
2349:
2344:
2338:
2336:
2323:
2317:
2316:
2313:
2312:
2309:
2308:
2306:
2305:
2300:
2295:
2290:
2285:
2280:
2274:
2272:
2262:
2261:
2259:
2258:
2252:
2250:
2240:
2239:
2237:
2236:
2230:
2228:
2215:
2209:
2208:
2205:
2204:
2202:
2201:
2195:
2194:
2188:
2186:
2173:
2164:
2158:
2157:
2154:
2153:
2150:
2149:
2147:
2146:
2136:
2134:
2124:
2123:
2121:
2120:
2114:
2112:
2099:
2093:
2092:
2089:
2088:
2086:
2085:
2079:
2077:
2064:
2058:
2057:
2054:
2053:
2051:
2050:
2044:
2042:
2038:
2037:
2034:
2033:
2031:
2030:
2025:
2019:
2017:
2007:
2006:
2004:
2003:
1997:
1995:
1982:
1976:
1975:
1972:
1971:
1969:
1968:
1963:
1957:
1955:
1945:
1944:
1942:
1941:
1936:
1930:
1928:
1915:
1909:
1908:
1905:
1904:
1902:
1901:
1895:
1893:
1883:
1882:
1880:
1879:
1874:
1869:
1864:
1859:
1853:
1851:
1838:
1829:
1820:
1808:
1807:
1798:
1796:
1795:
1788:
1781:
1773:
1767:
1766:
1758:
1750:
1738:
1737:
1734:
1733:
1721:
1720:
1718:
1714:
1713:
1710:
1709:
1698:
1687:
1679:
1664:
1644:
1639:
1638:
1636:
1635:Classification
1628:
1627:External links
1625:
1622:
1621:
1586:
1565:(6): 898–901.
1545:
1526:
1501:
1460:
1401:
1380:(3): 360–363.
1360:
1333:Can J Comp Med
1319:
1278:
1243:
1198:
1157:
1138:(8): 1368–74.
1122:
1086:
1075:
1061:
1050:
991:
950:
943:
916:
875:
856:
831:
797:
769:
758:
751:
726:
680:
635:
634:
632:
629:
615:adenocarcinoma
579:
576:
575:
574:
569:
564:
559:
554:
549:
544:
539:
534:
529:
527:Boston terrier
524:
519:
514:
509:
504:
494:
491:
489:, and uterus.
466:
463:
425:, examples of
381:Antihistamines
376:
373:
362:
361:
358:
355:
352:
331:
330:
327:
324:
293:differentiated
284:
281:
280:
279:
276:
269:
267:
264:
257:
255:
252:
245:
163:
160:
154:
151:
149:
146:
92:consisting of
88:is a type of
76:
75:
70:
64:
63:
59:
58:
50:
49:
46:
42:
41:
33:
24:
14:
13:
10:
9:
6:
4:
3:
2:
3215:
3204:
3201:
3199:
3196:
3194:
3191:
3189:
3186:
3184:
3181:
3180:
3178:
3163:
3160:
3158:
3155:
3154:
3152:
3150:
3146:
3140:
3137:
3135:
3132:
3130:
3127:
3125:
3122:
3120:
3117:
3115:
3112:
3110:
3107:
3105:
3102:
3100:
3097:
3095:
3092:
3091:
3089:
3087:
3083:
3073:
3070:
3068:
3065:
3063:
3060:
3058:
3055:
3053:
3050:
3048:
3045:
3043:
3040:
3038:
3035:
3033:
3030:
3026:
3023:
3022:
3021:
3018:
3017:
3014:
3008:
3005:
3001:
2998:
2997:
2996:
2992:
2988:
2985:
2984:
2982:
2979:
2974:
2968:
2964:
2961:
2960:
2958:
2955:
2954:Smooth muscle
2950:
2944:
2940:
2937:
2936:
2934:
2928:
2925:
2923:
2919:
2913:
2910:
2908:
2905:
2903:
2900:
2898:
2895:
2893:
2890:
2888:
2885:
2884:
2879:
2876:
2875:
2874:
2871:
2867:
2864:
2862:
2859:
2858:
2857:
2853:
2850:
2849:
2847:
2845:
2841:
2831:
2828:
2826:
2823:
2822:
2820:
2817:
2813:
2807:
2804:
2802:
2799:
2797:
2794:
2793:
2791:
2789:
2785:
2779:
2776:
2774:
2771:
2767:
2764:
2762:
2759:
2758:
2757:
2753:
2750:
2749:
2747:
2745:
2741:
2731:
2728:
2726:
2723:
2721:
2718:
2716:
2713:
2712:
2710:
2708:
2704:
2700:
2694:
2691:
2689:
2686:
2684:
2681:
2679:
2676:
2674:
2671:
2669:
2666:
2664:
2661:
2659:
2656:
2654:
2651:
2649:
2646:
2644:
2641:
2639:
2636:
2634:
2631:
2629:
2626:
2625:
2623:
2621:
2617:
2613:
2607:
2604:
2602:
2599:
2598:
2596:
2594:
2590:
2586:
2583:
2581:
2577:
2574:
2572:
2568:
2562:
2559:
2557:
2554:
2552:
2549:
2548:
2546:
2542:
2538:
2534:
2531:
2527:
2520:
2515:
2513:
2508:
2506:
2501:
2500:
2497:
2481:
2478:
2476:
2473:
2472:
2470:
2467:
2466:
2460:
2454:
2451:
2449:
2446:
2445:
2443:
2440:
2439:
2433:
2430:
2426:
2416:
2413:
2412:
2410:
2404:
2398:
2395:
2393:
2390:
2388:
2385:
2383:
2380:
2378:
2375:
2373:
2370:
2369:
2367:
2364:
2359:
2353:
2350:
2348:
2345:
2343:
2340:
2339:
2337:
2334:
2333:
2327:
2324:
2322:
2318:
2304:
2301:
2299:
2296:
2294:
2291:
2289:
2286:
2284:
2281:
2279:
2276:
2275:
2273:
2270:
2269:
2263:
2257:
2254:
2253:
2251:
2248:
2247:
2241:
2235:
2232:
2231:
2229:
2226:
2225:
2219:
2216:
2214:
2210:
2200:
2197:
2196:
2193:
2190:
2189:
2187:
2184:
2183:
2177:
2174:
2172:
2168:
2165:
2163:
2159:
2145:
2141:
2138:
2137:
2135:
2132:
2131:
2125:
2119:
2116:
2115:
2113:
2110:
2109:
2103:
2100:
2098:
2094:
2084:
2081:
2080:
2078:
2075:
2074:
2068:
2065:
2063:
2059:
2049:
2048:Histiocytosis
2046:
2045:
2043:
2039:
2029:
2026:
2024:
2021:
2020:
2018:
2015:
2014:
2008:
2002:
1999:
1998:
1996:
1993:
1992:
1986:
1983:
1981:
1980:Myelomonocyte
1977:
1967:
1964:
1962:
1959:
1958:
1956:
1953:
1952:
1946:
1940:
1937:
1935:
1932:
1931:
1929:
1926:
1925:
1919:
1916:
1914:
1910:
1900:
1897:
1896:
1894:
1891:
1890:
1884:
1878:
1875:
1873:
1870:
1868:
1865:
1863:
1860:
1858:
1855:
1854:
1852:
1849:
1848:
1842:
1839:
1837:
1833:
1830:
1828:
1824:
1821:
1819:
1813:
1809:
1805:
1801:
1794:
1789:
1787:
1782:
1780:
1775:
1774:
1771:
1765:
1763:
1759:
1757:
1755:
1751:
1749:
1747:
1743:
1742:
1732:
1728:
1727:
1723:
1722:
1719:
1715:
1708:
1704:
1703:
1699:
1697:
1693:
1692:
1688:
1685:
1684:
1680:
1678:
1674:
1673:
1669:
1665:
1663:
1659:
1655:
1654:
1650:
1646:
1645:
1642:
1637:
1633:
1626:
1617:
1613:
1609:
1605:
1601:
1597:
1590:
1587:
1582:
1578:
1573:
1568:
1564:
1560:
1556:
1549:
1546:
1541:
1537:
1530:
1527:
1515:
1511:
1505:
1502:
1497:
1493:
1488:
1483:
1479:
1475:
1471:
1464:
1461:
1456:
1452:
1448:
1444:
1439:
1434:
1429:
1424:
1421:(3): 177–83.
1420:
1416:
1412:
1405:
1402:
1397:
1393:
1388:
1383:
1379:
1375:
1371:
1364:
1361:
1356:
1352:
1347:
1342:
1338:
1334:
1330:
1323:
1320:
1315:
1311:
1306:
1301:
1297:
1293:
1289:
1282:
1279:
1274:
1270:
1266:
1262:
1258:
1254:
1247:
1244:
1239:
1235:
1230:
1225:
1221:
1217:
1213:
1209:
1202:
1199:
1194:
1190:
1185:
1180:
1176:
1172:
1168:
1161:
1158:
1153:
1149:
1145:
1141:
1137:
1133:
1126:
1123:
1118:
1114:
1110:
1106:
1103:(4): 933–40.
1102:
1098:
1090:
1087:
1084:
1079:
1076:
1071:
1065:
1062:
1059:
1054:
1051:
1046:
1042:
1037:
1032:
1027:
1022:
1018:
1014:
1010:
1006:
1002:
995:
992:
987:
983:
978:
973:
969:
965:
961:
954:
951:
946:
944:0-683-06105-4
940:
935:
934:
925:
923:
921:
917:
912:
908:
903:
898:
895:(3): 268–75.
894:
890:
886:
879:
876:
871:
867:
860:
857:
845:
841:
835:
832:
820:
816:
810:
808:
806:
804:
802:
798:
787:
783:
776:
774:
770:
767:
762:
759:
754:
752:9780071748896
748:
744:
740:
733:
731:
727:
722:
718:
714:
710:
706:
702:
698:
694:
687:
685:
681:
676:
672:
667:
662:
658:
654:
650:
643:
641:
637:
630:
628:
626:
623:
618:
616:
612:
608:
604:
600:
596:
591:
589:
585:
577:
573:
570:
568:
565:
563:
560:
558:
555:
553:
550:
548:
545:
543:
540:
538:
535:
533:
530:
528:
525:
523:
520:
518:
515:
513:
510:
508:
505:
503:
500:
499:
498:
492:
490:
488:
484:
480:
476:
472:
465:Other animals
464:
462:
458:
455:
451:
447:
442:
440:
436:
432:
428:
424:
420:
416:
414:
410:
406:
402:
398:
394:
390:
386:
382:
374:
372:
370:
366:
359:
356:
353:
351:
347:
346:
345:
343:
338:
336:
328:
325:
322:
321:
320:
318:
314:
310:
306:
302:
298:
294:
290:
282:
273:
268:
261:
256:
249:
244:
242:
240:
236:
232:
228:
224:
220:
216:
212:
208:
204:
200:
196:
192:
191:Darier's sign
187:
185:
181:
177:
173:
169:
161:
159:
152:
147:
145:
142:
138:
134:
130:
127:. Mast cell
126:
122:
118:
114:
113:immune system
110:
106:
101:
99:
95:
91:
87:
83:
74:
71:
69:
65:
60:
56:
51:
47:
43:
38:
30:
19:
3188:Cat diseases
3183:Dog diseases
3157:Mesothelioma
3114:Wilms' tumor
2801:Fibroadenoma
2703:Histiocytoma
2620:fibromatosis
2593:fibrosarcoma
2561:Skin sarcoma
2463:
2436:
2363:Mastocytosis
2331:
2330:
2266:
2244:
2222:
2180:
2128:
2106:
2071:
2011:
1989:
1949:
1922:
1887:
1845:
1818:granulocytes
1761:
1753:
1745:
1724:
1700:
1689:
1681:
1666:
1647:
1602:(4): 281–4.
1599:
1595:
1589:
1562:
1558:
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1518:. Retrieved
1513:
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1480:(2): 222–6.
1477:
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1339:(1): 115–7.
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1298:(8): 635–7.
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1214:(1): 151–8.
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843:
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818:
789:. Retrieved
785:
761:
742:
699:(4): 452–7.
696:
692:
659:(8): 620–2.
656:
652:
625:radiotherapy
622:strontium-90
619:
592:
588:Siamese cats
581:
517:Basset hound
496:
468:
459:
443:
417:
393:chemotherapy
378:
363:
339:
332:
313:inflammation
286:
207:mastocytosis
188:
165:
156:
141:mastocytosis
102:
85:
81:
79:
3149:Mesothelial
2987:Rhabdomyoma
2861:Myelolipoma
2856:liposarcoma
2773:Angiomyxoma
2756:myxosarcoma
2580:Fibromatous
2530:soft tissue
2332:Mastocytoma
1259:(1): 32–4.
1229:10871/37694
1177:(1): 91–5.
584:histiocytic
409:Vinblastine
401:H2 blockers
350:lymph nodes
239:bone marrow
235:lymph nodes
168:oncologists
105:bone marrow
82:mastocytoma
45:Other names
40:Mastocytoma
3177:Categories
3094:Adenomyoma
2943:myosarcoma
2844:Lipomatous
2744:Myxomatous
2526:Connective
1816:and other
1702:DiseasesDB
1520:2007-01-27
889:Vet Pathol
850:2007-01-27
825:2007-01-27
791:2006-08-19
693:Vet Pathol
631:References
532:Great Dane
522:Weimaraner
405:cimetidine
403:, such as
397:Prednisone
383:, such as
369:ultrasound
223:metastasis
94:mast cells
3025:Cutaneous
3020:Leiomyoma
2963:Leiomyoma
2922:Myomatous
2912:Hibernoma
1836:Myelocyte
1802:-related
1726:eMedicine
1686:: M9740/1
1292:Can Vet J
653:Can Vet J
446:prognosis
431:mast cell
423:masitinib
419:Toceranib
413:lomustine
283:Diagnosis
184:ulcerated
180:ulcerated
117:histamine
68:Specialty
2816:Synovial
2537:sarcomas
2321:CFU-Mast
2062:CFU-Baso
1913:Monocyte
1731:derm/258
1581:16536702
1496:10649758
1455:20724869
1447:16476559
1438:10832862
1314:11519274
1273:17236357
1238:16496935
1193:16426175
1152:15844431
1117:16955819
1045:19789626
1005:PLOS ONE
986:19470739
911:12724567
721:11717233
713:12126148
675:12170840
611:lymphoma
567:Shar pei
454:perineum
344:system:
317:necrosis
221:. When
215:duodenum
199:diarrhea
195:vomiting
178:) to an
129:granules
73:Oncology
2931:General
2616:Fibroma
2589:Fibroma
2171:CFU-Meg
2097:CFU-Eos
1934:AMoL/M5
1800:Myeloid
1696:D034801
1616:9657159
1396:7578452
1355:6424914
1346:1236018
1305:1476568
1036:2746281
1013:Bibcode
601:of the
595:splenic
512:Bulldog
487:omentum
483:viscera
441:drugs.
309:mitotic
211:stomach
162:Animals
133:heparin
2873:PEComa
2852:Lipoma
2752:Myxoma
2533:tumors
1877:APL/M3
1827:CFU-GM
1812:CFU-GM
1614:
1579:
1516:. 2006
1494:
1453:
1445:
1435:
1394:
1353:
1343:
1312:
1302:
1271:
1236:
1191:
1150:
1115:
1043:
1033:
984:
941:
909:
846:. 2006
821:. 2006
749:
719:
711:
673:
666:339404
663:
547:Beagle
479:cattle
471:horses
439:cancer
365:X-rays
301:biopsy
231:spleen
203:anemia
201:, and
176:lipoma
153:Humans
125:trauma
98:nodule
3072:STUMP
2939:Myoma
2818:-like
2213:CFU-E
2041:Other
2013:MD-MP
1707:34450
1683:ICD-O
1677:238.5
1662:D47.0
1658:C96.2
1451:S2CID
717:S2CID
502:Boxer
305:grade
227:liver
2535:and
1691:MeSH
1672:9-CM
1612:PMID
1577:PMID
1492:PMID
1443:PMID
1392:PMID
1351:PMID
1310:PMID
1269:PMID
1234:PMID
1189:PMID
1148:PMID
1113:PMID
1041:PMID
982:PMID
939:ISBN
907:PMID
747:ISBN
709:PMID
671:PMID
613:and
578:Cats
493:Dogs
477:and
475:pigs
421:and
411:and
237:and
213:and
172:wart
2438:AML
2224:AML
2162:MEP
2108:AML
2073:AML
1991:AML
1951:CML
1924:AML
1847:AML
1668:ICD
1649:ICD
1604:doi
1567:doi
1563:228
1482:doi
1478:216
1433:PMC
1423:doi
1382:doi
1341:PMC
1300:PMC
1261:doi
1224:hdl
1216:doi
1179:doi
1175:228
1140:doi
1136:226
1105:doi
1031:PMC
1021:doi
972:doi
897:doi
870:102
701:doi
661:PMC
562:Pug
391:or
342:WHO
315:or
84:or
3179::
2993::
2465:MP
2268:MD
2246:MP
2182:MP
2130:MP
2001:M4
1889:MP
1872:M2
1867:M1
1862:M0
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