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She is internationally recognized both for her work on the systems biology of kidney development and also for her pioneering studies into potential regenerative therapies in the kidney. In 2015, Professor
Melissa Little and her team at Murdoch Children’s Research Institute produced the world’s first
332:
Little is the 2021-2022 President of the
International Society for Stem Cell Research and Program Leader of Stem Cells Australia, an organisation that aims to "Bring together Australia's premier life scientists to tackle the big questions in stem cell science". She is also a guest editor with the
231:
enrolled through
Biochemistry at the University of Queensland (conferred 1990). An alumna of the University of Queensland, Brisbane, Australia, Melissa worked for more than 20 years at the Institute for Molecular Bioscience, where her research focused on the molecular basis of kidney development,
302:
to first and second trimester developing kidneys. Further research into the organoids by Prof Little's
Laboratory has demonstrated robust transcriptional reproducibility of the model and utilised induced pluripotent stem cells generated from patients to study their kidney disease.
714:
Takasato, Minoru; Er, Pei X.; Chiu, Han S.; Maier, Barbara; Baillie, Gregory J.; Ferguson, Charles; Parton, Robert G.; Wolvetang, Ernst J.; Roost, Matthias S. (22 October 2015). "Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis".
270:
Little and her team have developed an approach to recapitulate nephrogenesis, the formation of nephrons, in a dish. By knowing where the different kidney cells come from and how they develop she has developed a system to regenerate them from pluripotent stem cells. Using
311:
In the late 1990s, Little was a member of the
Strategic Review of Health and Medical Research, chaired by Peter Wills. This review proposed a Virtuous Cycle between research, government and the commercial sector . As a result of these recommendations, the budget of the
1247:
187:, and Program Leader of Stem Cells Australia. In January 2022, she became CEO of the Novo Nordisk Foundation Center for Stem Cell Medicine reNEW, an international stem cell research center based at University of Copenhagen, and a collaboration between the
566:
1357:
320:, Chief Scientist, to identify strategic priorities across Australian science. A member of the NHMRC Research Committee for 6 years, she was also a member of the most recent review of health and medical research, chaired by
1255:
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and directs the MCRI Stem Cell
Medicine Strategic Priority area. She is also the President of the Australasian Society for Stem Cell Research and a Board Member of the International Society for Stem Cell Research.
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37:
1021:
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The group were able to develop self organising organoids 7mm long over 18 days. These small balls of cells have differentiated most of the cells that form the kidneys, including
405:
519:
888:
Hale, Lorna J.; Howden, Sara E.; Phipson, Belinda; Lonsdale, Andrew; Er, Pei X.; Ghobrial, Irene; Hosawi, Salman; Wilson, Sean; Lawlor, Kynan T. (4 December 2018).
831:
Forbes, Thomas A.; Howden, Sara E.; Lawlor, Kynan; Phipson, Belinda; Maksimovic, Jovana; Hale, Lorna; Wilson, Sean; Quinlan, Catherine; Ho, Gladys (3 May 2018).
1347:
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kidney in a dish. Known today as kidney organoids, this research has become a foundation of ongoing work to find a regenerative solution for kidney disease.
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833:"Patient-iPSC-Derived Kidney Organoids Show Functional Validation of a Ciliopathic Renal Phenotype and Reveal Underlying Pathogenetic Mechanisms"
591:
443:
338:
179:
is an
Australian scientist and academic, currently Theme Director of Cell Biology, heading up the Kidney Regeneration laboratory at the
167:
29:
267:. Her work focuses on the molecular aspects of kidney development, with applications to stem cell biology and regenerative medicine.
460:
1278:
366:
196:
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She returned to
Australia to continue to work on WT1, but concentrating on its essential role in the normal development of the
227:
with 1st Class
Honours in Physiology in 1984. Her PhD studies were performed in the laboratory of Professor Peter Smith at the
774:
Phipson, Belinda; Er, Pei X; Combes, Alexander N; Forbes, Thomas A; Howden, Sara E; Zappia, Luke; et al. (January 2019).
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192:
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was doubled over the next 10 years. She went on to serve on the
Implementation Committee of that review and served under
1303:
981:"Enabling the virtuous cycle" : Implementation Committee report / Health and Medical Research Strategic Review
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from a patient, her group has described a cocktail of growth factors that can drive development into kidney cells.
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on 5 December 1963, the middle daughter of three girls. Her father, Ian Little, was a soils chemist with the
667:"A strategy for generating kidney organoids: Recapitulating the development in human pluripotent stem cells"
184:
1342:
995:
324:, which led to the establishment of the Medical Research Future Fund and the Biomedical Translation Fund.
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978:
Health and Medical Research Strategic Review (Australia). Implementation Committee; Wills, Peter (2000).
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890:"3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening"
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248:, a childhood kidney cancer. She was awarded a Royal Society Endeavour Fellowship to move to the
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567:"Prof. Melissa Little receives international award for achievements in kidney research"
1304:"Fellowship of the Australian Academy of Health & Medical Sciences – October 2015"
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183:. She is also a Professor in the Faculty of Medicine, Dentistry and Health Sciences,
417:
2013, Women in Technology Biotechnology and Outstanding Biotechnology Award Finalist
760:
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1248:"Honour for outstanding contribution to understanding genes controlling kidney"
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520:"New international research center to drive future stem cell-derived medicines"
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Human Genetics Unit in Edinburgh to undertake postdoctoral training with
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538:"Leiden Honorary Doctorates for Melissa Little and Robbert Dijkgraaf"
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481:"Professor Melissa Little | Murdoch Children's Research Institute"
421:
260:, the gene that is mutated in a subset of Wilm's tumour patients.
216:
1171:"Professor Melissa Little | Murdoch Childrens Research Institute"
1358:
Fellows of the Australian Academy of Health and Medical Sciences
1279:"The 2016 Eureka Prizes showcase the best in Australian science"
1047:"Melissa H. Little Assumes New Role as President of the ISSCR"
257:
428:
337:. She is the serving theme director of Cell Biology at the
996:"Further information on the Medical Research Future Fund"
665:
Takasato, Minoru; Little, Melissa H. (15 December 2016).
232:
renal disease and repair. In 2004 she graduated from the
240:
Research on kidney development, disease and regeneration
1146:"Cell Biology | Murdoch Childrens Research Institute"
1022:"A$ 250 million Biomedical Translation Fund to bridg"
776:"Evaluation of variability in human kidney organoids"
461:
Sylvia and Charles Viertel Senior Research Fellowship
1311:
Australian Academy of Health & Medical Sciences
147:
133:
117:
102:
79:
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23:
673:. The Development of Stem Cell-derived Organoids.
406:Australian Academy of Health and Medical Sciences
435:GlaxoSmithKline Award for Research Excellence
106:Developing the world's first kidney in a dish
16:Australian scientist and academic (born 1963)
8:
1363:Fellows of the Australian Academy of Science
314:National Health and Medical Research Council
244:Little started her research career studying
219:Cunningham laboratories. She graduated from
400:2016, Eureka Prize for Scientific Research
307:Contributions to Australian Science policy
46:
20:
1113:
929:
864:
807:
690:
633:
439:2004, NHMRC Principal Research Fellowship
362:2023, Companion of the Order of Australia
234:Australian Institute of Company Directors
229:Queensland Institute of Medical Research
87:Queensland Institute of Medical Research
1196:"Australia Day 2023 Honours: Full list"
472:
456:2002, NHMRC Senior Research Fellowship
223:in 1980. She completed her BSc at the
954:"Peter Wills AC – RESEARCH AUSTRALIA"
193:Murdoch Children’s Research Institute
181:Murdoch Children's Research Institute
142:Murdoch Children's Research Institute
7:
1348:Companions of the Order of Australia
560:
558:
532:
530:
449:2004, Australian Academy of Science
424:Senior Principal Research Fellowship
339:Murdoch Childrens Research Institute
1096:Vicente, Catarina (15 March 2016).
616:Vicente, Catarina (15 March 2016).
1254:. 18 February 2020. Archived from
1098:"An interview with Melissa Little"
837:American Journal of Human Genetics
565:Braybrook, Helen (16 April 2019).
14:
1072:"Welcome to Stem Cells Australia"
506:"Pursuit University of Melbourne"
369:, American Society of Nephrology
197:Leiden University Medical Center
1373:University of Queensland alumni
410:2015, Boerhaave Professorship,
1353:Australian medical researchers
1226:American Society of Nephrology
1020:Commission, Australian Trade.
383:, World Congress of Nephrology
256:. Here she worked on the gene
1:
1252:School of Biomedical Sciences
1076:www.stemcellsaustralia.edu.au
596:www.stemcellsaustralia.edu.au
571:School of Biomedical Sciences
395:Australian Academy of Science
381:Alfred Newton Richards Award
683:10.1016/j.ydbio.2016.08.024
211:Melissa Little was born in
1389:
914:10.1038/s41467-018-07594-z
849:10.1016/j.ajhg.2018.03.014
618:"An interview with Little"
386:2019, Honorary doctorate,
298:, and are closely related
1200:The Sydney Morning Herald
792:10.1038/s41592-018-0253-2
376:, Lorne GENOME Conference
328:Professional associations
221:Kenmore State High School
157:
110:
45:
250:Medical Research Council
225:University of Queensland
207:Early life and education
189:University of Copenhagen
138:University of Copenhagen
93:University of Queensland
1222:"2021 Award Recipients"
185:University of Melbourne
74:, Queensland, Australia
277:pluripotent stem cells
894:Nature Communications
671:Developmental Biology
429:Eisenhower Fellowship
290:, vasculature cells,
1368:People from Brisbane
412:University of Leiden
404:2015, Fellow of the
393:2017, Fellow of the
388:University of Leiden
367:Homer W. Smith Award
273:embryonic stem cells
164:Melissa Helen Little
1258:on 7 September 2021
1026:www.austrade.gov.au
906:2018NatCo...9.5167H
737:10.1038/nature15695
729:2015Natur.526..564T
522:. 17 December 2021.
453:in Medical Sciences
333:scientific journal
213:Brisbane, Australia
199:, The Netherlands.
1115:10.1242/dev.135897
958:RESEARCH AUSTRALIA
635:10.1242/dev.135897
374:Julian Wells Medal
346:Awards and honours
300:transcriptionallly
1202:. 25 January 2023
1000:www.health.gov.au
723:(7574): 564–568.
542:Leiden University
414:, The Netherlands
390:, The Netherlands
265:urogenital system
195:, Australia, and
161:
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112:Scientific career
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1283:The Conversation
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451:Gottschalk Medal
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284:collecting ducts
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149:Doctoral advisor
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1228:. 16 April 2019
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1175:www.mcri.edu.au
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318:Robin Batterham
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254:Nicholas Hastie
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80:Alma mater
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65:5 December 1963
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1108:(6): 907–909.
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1038:
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945:
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843:(5): 816–831.
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780:Nature Methods
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628:(6): 907–909.
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25:Melissa Little
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1314:. Retrieved
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1256:the original
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484:
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444:The Bulletin
331:
322:Simon McKeon
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134:Institutions
111:
18:
1338:1963 births
1277:Dean, Tim.
1262:7 September
1232:7 September
1102:Development
900:(1): 5167.
622:Development
335:Development
191:, Denmark,
153:Peter Smith
1332:Categories
1316:12 October
1206:25 January
1056:7 November
547:8 February
467:References
122:Nephrology
95:(BSc 1984)
89:(PhD 1990)
61:1963-12-05
1288:25 August
1180:25 August
1155:29 August
1124:0950-1991
1081:29 August
922:2041-1723
857:0002-9297
800:1548-7105
745:0028-0836
644:0950-1991
446:Smart 100
288:podocytes
128:Organoids
125:Stem Cell
1132:26980790
940:30514835
875:29706353
818:30573816
753:26444236
701:27565022
652:26980790
292:nephrons
72:Brisbane
931:6279764
902:Bibcode
866:5986969
809:6634992
761:4443766
725:Bibcode
692:6186756
601:25 July
576:25 July
490:25 July
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592:"News"
459:1997,
433:2005,
427:2006,
420:2013,
379:2019,
372:2020,
365:2021,
350:": -->
118:Fields
1307:(PDF)
757:S2CID
422:NHMRC
217:CSIRO
176:FAHMS
174:
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38:FAHMS
36:
32:
1318:2018
1290:2017
1264:2020
1234:2021
1208:2023
1182:2017
1157:2017
1128:PMID
1120:ISSN
1083:2017
1058:2021
1033:2017
1007:2017
965:2017
936:PMID
918:ISSN
871:PMID
853:ISSN
814:PMID
796:ISSN
749:PMID
741:ISSN
697:PMID
648:PMID
640:ISSN
603:2019
578:2019
549:2019
492:2019
352:edit
294:and
55:Born
1110:doi
1106:143
984:. .
926:PMC
910:doi
861:PMC
845:doi
841:102
804:PMC
788:doi
733:doi
721:526
687:PMC
679:doi
675:420
630:doi
626:143
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