336:
223:
570:
575:
527:
58:
565:
537:
532:
522:
49:
40:
671:
369:
InChI=1/C20H9Br2O5.Hg.2Na.H2O/c21-13-5-11-17(7-15(13)23)27-18-8-16(24)14(22)6-12(18)19(11)9-3-1-2-4-10(9)20(25)26;;;;/h1-7,24H,(H,25,26);;;;1H2/q;3*+1;/p-3/rC20H10Br2HgO6.2Na/c21-12-5-10-15(7-14(12)24)29-19-11(6-13(22)18(25)17(19)23-28)16(10)8-3-1-2-4-9(8)20(26)27;;/h1-7,25,28H,(H,26,27);;/q;2*+1/p-2
1027:
Se ha estudiado en 72 pacientes la eficacia de la merbromina comparativamente con la clorhexidina como antisépticos usados en la curación de múltiples afecciones en el pie diabético. Con el uso de merbromina se consigue disminuir apreciablemente el tiempo de cicatrización de las heridas, y se ha
869:(FDA) reclassified merbromin from "generally recognized as safe" to "untested," effectively halting its distribution within the United States. Sales were subsequently halted in Brazil (2001), Germany (2003), and France (2006). It remains readily available in most other countries.
793:
In 1998, the U.S. Food and Drug
Administration reclassified merbromin from "generally recognized as safe" to "untested," due to a lack of recent studies or updated supporting information. Consequently, its use in the United States has been superseded by other agents (e.g.,
120:
814:
Merbromin is synthesized by combining dibromofluorescein with mercuric acetate and sodium hydroxide or, alternatively, through action of the mercuric acetate upon (or combining with) sodium dibromofluorescein. Because of its
583:
545:
858:. The chemical soon became popular among parents and physicians for everyday antiseptic uses, in part because the dye component made it easy to see where the antiseptic had been applied.
1040:
2046:
974:
478:
782:, and the antisepsis of wounds with inhibited scar formation, such as neuropathic ulcers and diabetic foot sores. When applied on a wound, it stains the skin a distinctive
684:
866:
385:
359:
InChI=1S/C20H9Br2O5.Hg.2Na.H2O/c21-13-5-11-17(7-15(13)23)27-18-8-16(24)14(22)6-12(18)19(11)9-3-1-2-4-10(9)20(25)26;;;;/h1-7,24H,(H,25,26);;;;1H2/q;3*+1;/p-3
2039:
1223:
1179:
762:. Readily available in most countries, it is no longer sold in Switzerland, Brazil, France, Iran, Germany, Denmark, or the United States, due to its
932:
2032:
827:
Merbromin is sold under the trade name
Mercurochrome (in which the suffix "- chrome" denotes "color"). The name is also commonly used for
2487:
1155:
2225:
940:
350:
2546:
2326:
1550:
1216:
880:") play on the brand recognition history of Mercurochrome but substitute other ingredients with similar properties. In Canada,
877:
1673:
1075:
504:
2556:
2279:
645:
2551:
653:
627:
293:
998:
Sellares Casas, E; et al. "Eficacia de una aplicación frente a 3 de merbromina en el tiempo de caída del cordón".
574:
569:
2504:
1689:
314:
2473:
1534:
1209:
691:
615:
230:
1118:
819:
character, it is chemically incompatible with acids, the majority of alkaloid salts and most local anesthetics.
2311:
1183:
2492:
1506:
1017:
Gaitan Enríquez, J (September 1997). "Merbromina como tratamiento de elección en úlceras de pie diabético".
218:
2541:
2438:
2345:
1657:
1393:
909:
855:
160:
2350:
2292:
2287:
2006:
1641:
1621:
1514:
1465:
828:
799:
597:
564:
557:
70:
2536:
2531:
2404:
2355:
2321:
2305:
2235:
1880:
1723:
1457:
1441:
1336:
957:
832:
619:
2443:
2301:
2081:
1978:
1970:
1962:
1941:
1931:
1926:
1921:
1916:
1898:
1498:
1481:
1449:
1433:
1417:
1385:
1287:
1275:
331:
86:
2375:
1473:
1360:
1348:
1311:
1263:
1251:
1246:
633:
1180:"Antiseptique solution de premiers soins sans mercure, 25 ml – Personnelle : Désinfectant"
1162:
2458:
2417:
2336:
2113:
1954:
1949:
1911:
1493:
1412:
1299:
1232:
1071:
862:
763:
748:
180:
1402:
1327:
1130:
881:
844:
745:
408:
1041:"Status of Certain Additional Over-the-Counter Drug Category II and III Active Ingredients"
873:
302:
2230:
2152:
2086:
1605:
1577:
1522:
1407:
795:
526:
57:
96:
335:
222:
2498:
2394:
2259:
1906:
1589:
779:
662:
140:
2024:
778:
to treat minor wounds, burns, and scratches. It is also used in the antisepsis of the
2525:
2206:
2177:
2118:
1986:
1567:
1134:
885:
851:
803:
787:
739:
211:
786:
red, which can persist through repeated washings. Due to its persistence and to its
536:
2468:
2264:
2172:
2157:
2133:
2063:
2059:
1994:
1064:
637:
531:
521:
489:
484:
641:
282:
2365:
2297:
2254:
2123:
1821:
1706:
1091:
903:
48:
2453:
2412:
2370:
2269:
2197:
2182:
2128:
2055:
1841:
897:
775:
755:
451:
171:
17:
2316:
2245:
2187:
2167:
2101:
2091:
835:
consisting of merbromin (typically at 2% concentration) dissolved in either
649:
39:
607:
2448:
2072:
1756:
1028:
observado también una ausencia de complicaciones en los casos estudiados.
840:
191:
1119:"A New Germicide for Use in the Genito-Urinary Tract: Mercurochrome-220"
933:"Quantitative and Qualitative Analysis of Mercury Compounds in the List"
200:
2422:
2105:
836:
783:
752:
269:
231:
2385:
2216:
2162:
2143:
1066:
The Merck Index, An
Encyclopedia of Chemicals, Drugs, and Biologicals
742:
151:
1201:
661:
Except where otherwise noted, data are given for materials in their
257:
2463:
1098:(in French). Centre National de Ressources Textuelles et Lexicales
790:, Merbromin is useful on infections of the fingernail or toenail.
603:
131:
119:
109:
611:
248:
2028:
1205:
816:
759:
393:..C(=O)c4ccccc4C=1c3cc(Br)c()c(O)c3O/C/2=C/C(=O)C(/Br)=C\C=1\2
319:
1070:(11 ed.). Rahway, New Jersey, USA.: Merck & Co.
29:
Organomercuric antiseptic for external use on minor cuts
679:
850:
Its antiseptic qualities were discovered in 1918 by
2431:
2403:
2384:
2335:
2278:
2244:
2215:
2196:
2142:
2100:
2071:
1940:
1897:
1873:
1566:
1378:
1239:
937:
Federal Food, Drug, and
Cosmetic Act (FD&C Act)
1063:
906:, an organomercury antiseptic and antifungal agent
878:benzalkonium chloride and lidocaine hydrochloride
281:
758:for minor cuts and scrapes and as a biological
95:
2040:
1217:
8:
958:"Merbromin im Spiegel der Expertenmeinungen"
1123:Journal of the American Medical Association
872:Within the United States, products such as
774:Merbromin's best-known use is as a topical
2047:
2033:
2025:
1563:
1224:
1210:
1202:
334:
221:
179:
31:
1096:Trésor de la Langue Française informatisé
900:, also known as Thimerosal or Merthiolate
861:On 19 October 1998, citing potential for
301:
975:"Prospecto autorizado Mercromina Film ®"
921:
888:solution under the name Mercurochrome.
390:
355:
330:
199:
212:
518:Toxic, dangerous for the environment
362:Key: SQFDQLBYJKFDDO-UHFFFAOYSA-K
159:
139:
7:
952:
950:
927:
925:
488:
876:Mercuroclear ("Aqueous solution of
372:Key: SQFDQLBYJKFDDO-ISOIBTJNAR
272:
256:
2226:Iodine/octylphenoxypolyglycolether
25:
941:U.S. Food and Drug Administration
2327:Didecyldimethylammonium chloride
1135:10.1001/jama.1919.02610460001001
1117:Young, Hugh (15 November 1919).
669:
573:
568:
563:
535:
530:
525:
520:
420:
74:dibromohydroxymercurifluorescein
56:
47:
38:
2418:Isopropanol (isopropyl alcohol)
867:US Food and Drug Administration
665:(at 25 °C , 100 kPa).
432:
426:
2469:Chloramine-T (tosylchloramide)
505:Occupational safety and health
441:
435:
414:
1:
2280:Quaternary ammonium compounds
1062:Budavary, Susan, ed. (1989).
2573:
2474:Octenidine dihydrochloride
2482:
2413:Propanol (propyl alcohol)
659:
544:
502:
497:
471:
401:
381:
346:
79:
69:
64:
55:
46:
37:
1000:Acta Pediátrica Española
628:Precautionary statements
2547:Organomercury compounds
2423:Ethanol (ethyl alcohol)
1161:. Humco. Archived from
910:Phenyl mercuric nitrate
2439:Potassium permanganate
2346:Mercuric amidochloride
856:Johns Hopkins Hospital
2351:Phenylmercuric borate
2293:Benzethonium chloride
800:benzalkonium chloride
788:lethality to bacteria
2557:Organic sodium salts
2322:Benzoxonium chloride
2236:Diiodohydroxypropane
1051:(77). 22 April 1998.
963:. 22 September 2003.
2552:Triarylmethane dyes
2444:Sodium hypochlorite
2082:Ethacridine lactate
1156:"Mercuroclear MSDS"
720:Sodium mercurescein
459: g·mol
34:
2509:Never to phase III
692:Infobox references
32:
2519:
2518:
2459:Hydrogen peroxide
2356:Mercuric chloride
2114:Dibrompropamidine
2022:
2021:
1869:
1868:
1233:Mercury compounds
1129:(20): 1483–1491.
863:mercury poisoning
854:, a physician at
700:Chemical compound
698:
697:
598:Hazard statements
315:CompTox Dashboard
121:Interactive image
16:(Redirected from
2564:
2049:
2042:
2035:
2026:
1752:
1751:
1750:
1742:
1741:
1733:
1732:
1564:
1226:
1219:
1212:
1203:
1196:
1195:
1193:
1191:
1182:. Archived from
1176:
1170:
1169:
1168:on 3 March 2016.
1167:
1160:
1152:
1146:
1145:
1143:
1141:
1114:
1108:
1107:
1105:
1103:
1088:
1082:
1081:
1069:
1059:
1053:
1052:
1045:Federal Register
1037:
1031:
1030:
1014:
1008:
1007:
995:
989:
988:
986:
984:
979:
971:
965:
964:
954:
945:
944:
943:. 30 April 2009.
929:
882:Jean Coutu Group
829:over-the-counter
682:
676:
673:
672:
655:
651:
647:
643:
639:
635:
621:
617:
613:
609:
605:
577:
572:
567:
539:
534:
529:
524:
492:
467:dark red liquid
458:
443:
437:
434:
428:
422:
416:
409:Chemical formula
339:
338:
323:
321:
305:
285:
274:
260:
233:
225:
214:
203:
183:
163:
143:
123:
99:
60:
51:
42:
35:
21:
2572:
2571:
2567:
2566:
2565:
2563:
2562:
2561:
2522:
2521:
2520:
2515:
2514:
2499:Clinical trials
2478:
2427:
2399:
2380:
2376:Mercuric iodide
2331:
2312:Cetylpyridinium
2274:
2240:
2231:Povidone-iodine
2211:
2192:
2153:Hexachlorophene
2146:and derivatives
2138:
2096:
2087:9-Aminoacridine
2067:
2053:
2023:
2018:
2014:
2010:
2002:
1998:
1990:
1982:
1974:
1966:
1958:
1942:Mercury cations
1936:
1893:
1884:
1865:
1861:
1857:
1853:
1849:
1845:
1837:
1833:
1829:
1825:
1817:
1813:
1809:
1805:
1801:
1797:
1793:
1784:
1780:
1776:
1772:
1768:
1764:
1760:
1749:
1746:
1745:
1744:
1740:
1737:
1736:
1735:
1731:
1728:
1727:
1726:
1724:
1718:
1714:
1710:
1701:
1697:
1693:
1685:
1681:
1677:
1669:
1665:
1661:
1653:
1649:
1645:
1637:
1633:
1629:
1625:
1617:
1613:
1609:
1601:
1597:
1593:
1585:
1581:
1570:
1562:
1558:
1554:
1546:
1542:
1538:
1530:
1526:
1518:
1510:
1502:
1489:
1485:
1477:
1469:
1461:
1453:
1445:
1437:
1429:
1425:
1421:
1397:
1389:
1374:
1364:
1356:
1352:
1344:
1340:
1331:
1323:
1319:
1315:
1307:
1303:
1295:
1291:
1283:
1279:
1271:
1267:
1259:
1255:
1235:
1230:
1200:
1199:
1189:
1187:
1186:on 2 April 2019
1178:
1177:
1173:
1165:
1158:
1154:
1153:
1149:
1139:
1137:
1116:
1115:
1111:
1101:
1099:
1092:"Mercurochrome"
1090:
1089:
1085:
1078:
1061:
1060:
1056:
1039:
1038:
1034:
1016:
1015:
1011:
997:
996:
992:
982:
980:
977:
973:
972:
968:
956:
955:
948:
931:
930:
923:
918:
894:
825:
812:
796:povidone iodine
772:
701:
694:
689:
688:
687: ?)
678:
674:
670:
666:
630:
600:
586:
560:
515:
481:
456:
446:
440:
431:
425:
419:
411:
397:
394:
389:
388:
377:
374:
373:
370:
364:
363:
360:
354:
353:
342:
324:
317:
308:
288:
275:
263:
243:
206:
186:
166:
146:
126:
113:
102:
89:
75:
30:
23:
22:
15:
12:
11:
5:
2570:
2568:
2560:
2559:
2554:
2549:
2544:
2539:
2534:
2524:
2523:
2517:
2516:
2513:
2512:
2511:
2510:
2507:
2496:
2490:
2484:
2483:
2480:
2479:
2477:
2476:
2471:
2466:
2461:
2456:
2451:
2446:
2441:
2435:
2433:
2429:
2428:
2426:
2425:
2420:
2415:
2409:
2407:
2401:
2400:
2398:
2397:
2395:Silver nitrate
2391:
2389:
2382:
2381:
2379:
2378:
2373:
2368:
2363:
2358:
2353:
2348:
2342:
2340:
2333:
2332:
2330:
2329:
2324:
2319:
2314:
2309:
2295:
2290:
2284:
2282:
2276:
2275:
2273:
2272:
2267:
2262:
2260:Chlorquinaldol
2257:
2251:
2249:
2242:
2241:
2239:
2238:
2233:
2228:
2222:
2220:
2213:
2212:
2210:
2209:
2203:
2201:
2194:
2193:
2191:
2190:
2185:
2180:
2175:
2170:
2165:
2160:
2155:
2149:
2147:
2140:
2139:
2137:
2136:
2131:
2126:
2121:
2116:
2110:
2108:
2098:
2097:
2095:
2094:
2089:
2084:
2078:
2076:
2069:
2068:
2054:
2052:
2051:
2044:
2037:
2029:
2020:
2019:
2017:
2016:
2012:
2008:
2004:
2000:
1996:
1992:
1988:
1984:
1980:
1976:
1972:
1968:
1964:
1960:
1956:
1952:
1946:
1944:
1938:
1937:
1935:
1934:
1929:
1924:
1919:
1914:
1909:
1903:
1901:
1895:
1894:
1892:
1891:
1882:
1877:
1875:
1871:
1870:
1867:
1866:
1864:
1863:
1859:
1855:
1851:
1847:
1843:
1839:
1835:
1831:
1827:
1823:
1819:
1815:
1811:
1807:
1803:
1799:
1795:
1791:
1787:
1782:
1778:
1774:
1770:
1766:
1762:
1758:
1754:
1747:
1738:
1729:
1721:
1716:
1712:
1708:
1704:
1699:
1695:
1691:
1687:
1683:
1679:
1675:
1671:
1667:
1663:
1659:
1655:
1651:
1647:
1643:
1639:
1635:
1631:
1627:
1623:
1619:
1615:
1611:
1607:
1603:
1599:
1595:
1591:
1587:
1583:
1579:
1574:
1572:
1561:
1560:
1556:
1552:
1548:
1544:
1540:
1536:
1532:
1528:
1524:
1520:
1516:
1512:
1508:
1504:
1500:
1496:
1491:
1487:
1483:
1479:
1475:
1471:
1467:
1463:
1459:
1455:
1451:
1447:
1443:
1439:
1435:
1431:
1427:
1423:
1419:
1415:
1410:
1405:
1400:
1395:
1391:
1387:
1382:
1380:
1376:
1375:
1373:
1372:
1362:
1358:
1354:
1350:
1346:
1342:
1338:
1334:
1329:
1325:
1321:
1317:
1313:
1309:
1305:
1301:
1297:
1293:
1289:
1285:
1281:
1277:
1273:
1269:
1265:
1261:
1257:
1253:
1249:
1243:
1241:
1237:
1236:
1231:
1229:
1228:
1221:
1214:
1206:
1198:
1197:
1171:
1147:
1109:
1083:
1076:
1054:
1032:
1009:
990:
966:
946:
920:
919:
917:
914:
913:
912:
907:
901:
893:
890:
824:
821:
811:
808:
780:umbilical cord
771:
768:
740:organomercuric
699:
696:
695:
690:
668:
667:
663:standard state
660:
657:
656:
631:
626:
623:
622:
601:
596:
593:
592:
587:
582:
579:
578:
561:
556:
553:
552:
542:
541:
516:
513:
510:
509:
500:
499:
495:
494:
482:
477:
474:
473:
469:
468:
465:
461:
460:
454:
448:
447:
444:
438:
429:
423:
417:
412:
407:
404:
403:
399:
398:
396:
395:
392:
384:
383:
382:
379:
378:
376:
375:
371:
368:
367:
365:
361:
358:
357:
349:
348:
347:
344:
343:
341:
340:
327:
325:
313:
310:
309:
307:
306:
298:
296:
290:
289:
287:
286:
278:
276:
268:
265:
264:
262:
261:
253:
251:
245:
244:
242:
241:
237:
235:
227:
226:
216:
208:
207:
205:
204:
196:
194:
188:
187:
185:
184:
176:
174:
168:
167:
165:
164:
156:
154:
148:
147:
145:
144:
136:
134:
128:
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2205:
2204:
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2181:
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2178:Chloroxylenol
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2119:Chlorhexidine
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18:Mercurochrome
2360:
2288:Benzalkonium
2265:Oxyquinoline
2173:Triclocarban
2158:Policresulen
2134:Polihexanide
1888:hypothetical
1887:
1789:
1369:hypothetical
1368:
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1184:the original
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514:Main hazards
503:
80:Identifiers
26:
2537:Bromoarenes
2532:Antiseptics
2495:from market
2366:Nitromersol
2298:Cetrimonium
2255:Dequalinium
2248:derivatives
2200:derivatives
2124:Propamidine
2075:derivatives
2056:Antiseptics
1874:Mercury(IV)
1379:Mercury(II)
904:Nitromersol
831:antiseptic
736:Cinfacromin
584:Signal word
508:(OHS/OSH):
464:Appearance
402:Properties
219:100.004.486
2526:Categories
2454:Monalazone
2371:Thiomersal
2270:Clioquinol
2198:Nitrofuran
2183:Biphenylol
2129:Hexamidine
2102:Biguanides
1240:Mercury(I)
1077:091191028X
916:References
898:Thiomersal
884:markets a
776:antiseptic
756:antiseptic
751:used as a
728:Supercrome
716:Mercurocol
712:Merbromine
558:Pictograms
452:Molar mass
303:M0T18YH28D
172:ChemSpider
141:CHEBI:6763
108:3D model (
87:CAS Number
71:IUPAC name
33:Merbromin
2505:Phase III
2493:Withdrawn
2388:compounds
2361:Merbromin
2337:Mercurial
2317:Cetrimide
2246:Quinoline
2188:Fenticlor
2168:Triclosan
2092:Euflavine
1571:compounds
833:solutions
810:Synthesis
766:content.
732:Brocasept
704:Merbromin
654:P301+P310
549:labelling
240:204-933-6
232:EC Number
2449:Halazone
2405:Alcohols
2339:products
2306:chloride
2219:products
2106:amidines
2073:Acridine
1899:Amalgams
1535:Hg(Si(CH
1102:11 April
892:See also
841:tincture
749:compound
743:disodium
738:) is an
498:Hazards
493:)
479:ATC code
192:DrugBank
181:10808965
97:129-16-8
2302:bromide
1806:OBrOCHC
1515:Hg(CNO)
1507:Hg(SCN)
1190:2 April
845:aqueous
817:anionic
784:carmine
764:mercury
753:topical
685:what is
683: (
487: (
485:D08AK04
457:750.658
270:PubChem
201:DB13392
2488:WHO-EM
2386:Silver
2217:Iodine
2163:Phenol
2144:Phenol
1932:Sn(Hg)
1927:Tl(Hg)
1922:Au(Hg)
1912:Al(Hg)
1907:Na(Hg)
1757:HgOHCH
1719:(NHCO)
1707:HgOHCH
1650:OB(OH)
1466:Hg(OH)
1450:Hg(CN)
1140:8 July
1074:
983:15 May
865:, the
680:verify
677:
590:Danger
386:SMILES
258:D00861
152:ChEMBL
65:Names
2464:Eosin
2432:Other
1917:K(Hg)
1842:NaHgC
1798:HOBrC
1794:HgOHC
1769:NHCOC
1761:CHOCH
1711:CHOCH
1690:HgClC
1578:Hg(CH
1482:Hg(NO
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110:JSmol
2104:and
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