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113:
138:
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1263:
699:
enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which
1215:
Labbaye C, Spinello I, Quaranta MT, Pelosi E, Pasquini L, Petrucci E, Biffoni M, Nuzzolo ER, Billi M, Foà R, Brunetti E, Grignani F, Testa U, Peschle C (July 2008). "A three-step pathway comprising PLZF/miR-146a/CXCR4 controls megakaryopoiesis".
684:(miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by
700:
recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.
1089:
Stanczyk J, Pedrioli DM, Brentano F, Sanchez-Pernaute O, Kolling C, Gay RE, Detmar M, Gay S, Kyburz D (April 2008). "Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis".
151:
986:
Sonkoly E, Wei T, Janson PC, Sääf A, Lundeberg L, Tengvall-Linder M, Norstedt G, Alenius H, Homey B, Scheynius A, Ståhle M, Pivarcsi A (July 2007). Zimmer J (ed.).
880:
He H, Jazdzewski K, Li W, Liyanarachchi S, Nagy R, Volinia S, Calin GA, Liu CG, Franssila K, Suster S, Kloos RT, Croce CM, de la
Chapelle A (December 2005).
401:
1121:"Rapid changes in microRNA-146a expression negatively regulate the IL-1beta-induced inflammatory response in human lung alveolar epithelial cells"
1332:
738:
692:
and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the
1308:
1327:
610:
1048:"Epstein-Barr virus latent membrane protein 1 induces cellular MicroRNA miR-146a, a modulator of lymphocyte signaling pathways"
725:
935:"NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses"
137:
112:
759:
721:
70:
150:
143:
1301:
1046:
Cameron JE, Yin Q, Fewell C, Lacey M, McBride J, Wang X, Lin Z, Schaefer BC, Flemington EK (February 2008).
444:
1164:"Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma"
1038:
829:"Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells"
1294:
1175:
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946:
893:
840:
797:
126:
57:
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86:
1233:
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1150:
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1027:
974:
921:
868:
815:
685:
50:
1278:
1119:
Perry MM, Moschos SA, Williams AE, Shepherd NJ, Larner-Svensson HM, Lindsay MA (April 2008).
82:
1225:
1193:
1183:
1162:
Jazdzewski K, Murray EL, Franssila K, Jarzab B, Schoenberg DR, de la
Chapelle A (May 2008).
1140:
1132:
1099:
1067:
1059:
1017:
1007:
964:
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911:
901:
858:
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805:
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230:
161:
205:
1179:
1003:
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844:
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1120:
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Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T (April 2002).
223:
103:
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90:
1136:
743:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1168:
Proceedings of the
National Academy of Sciences of the United States of America
939:
Proceedings of the
National Academy of Sciences of the United States of America
886:
Proceedings of the
National Academy of Sciences of the United States of America
833:
Proceedings of the
National Academy of Sciences of the United States of America
120:
1188:
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365:
323:
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189:
176:
78:
1237:
1207:
1154:
1111:
1081:
1031:
978:
925:
872:
819:
653:
1063:
681:
642:
988:"MicroRNAs: novel regulators involved in the pathogenesis of psoriasis?"
17:
473:
430:
1103:
827:
Cai X, Lu S, Zhang Z, Gonzalez CM, Damania B, Cullen BR (April 2005).
693:
623:
387:
1262:
1229:
491:
487:
1270:
675:
74:
933:
Taganov KD, Boldin MP, Chang KJ, Baltimore D (August 2006).
882:"The role of microRNA genes in papillary thyroid carcinoma"
786:"Identification of tissue-specific microRNAs from mouse"
213:
1282:
61:, MIRN146, MIRN146A, miR-146a, miRNA146A, microRNA 146a
335:
588:
569:
545:
526:
717:
715:
713:
160:
1302:
8:
722:GRCh38: Ensembl release 89: ENSG00000283733
1309:
1295:
361:
201:
98:
27:Non-coding RNA in the species Homo sapiens
1197:
1187:
1144:
1071:
1021:
1011:
968:
958:
915:
905:
862:
852:
809:
674:that in humans is encoded by the MIR146A
754:
752:
709:
31:
165:
124:
119:
7:
1259:
1257:
1281:. You can help Knowledge (XXG) by
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25:
1261:
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149:
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111:
324:More reference expression data
1:
1333:Human chromosome 5 gene stubs
811:10.1016/S0960-9822(02)00809-6
134:
1013:10.1371/journal.pone.0000610
760:"Entrez Gene: MicroRNA 146a"
1328:Genes on human chromosome 5
1137:10.4049/jimmunol.180.8.5689
1349:
1256:
279:left lobe of thyroid gland
739:"Human PubMed Reference:"
657:
652:
648:
641:
622:
611:Chr 5: 160.49 – 160.49 Mb
605:
592:
573:
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34:
1092:Arthritis and Rheumatism
1189:10.1073/pnas.0802682105
960:10.1073/pnas.0605298103
907:10.1073/pnas.0509603102
854:10.1073/pnas.0408192102
1125:Journal of Immunology
1064:10.1128/JVI.02136-07
271:gastrocnemius muscle
127:Chromosome 5 (human)
1218:Nature Cell Biology
1180:2008PNAS..105.7269J
1052:Journal of Virology
1004:2007PLoSO...2..610S
951:2006PNAS..10312481T
898:2005PNAS..10219075H
845:2005PNAS..102.5570C
802:2002CBio...12..735L
91:MIR146A - orthologs
1269:This article on a
1290:
1289:
1104:10.1002/art.23386
686:RNA polymerase II
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664:
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16:(Redirected from
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1042:
1041:
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892:(52): 19075–80.
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856:
823:
813:
770:
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746:
735:
729:
719:
697:ribonuclease III
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563:RefSeq (protein)
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1174:(20): 7269–74.
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985:
945:(33): 12481–6.
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790:Current Biology
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777:Further reading
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654:View/Edit Human
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606:Location (UCSC)
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532:
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445:ENSG00000283733
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102:Gene location (
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1224:(7): 788–801.
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1159:
1131:(8): 5689–98.
1116:
1086:
1058:(4): 1946–58.
1043:
983:
930:
877:
839:(15): 5570–5.
824:
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771:
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672:non-coding RNA
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1098:(4): 1001–9.
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669:
668:MicroRNA 146a
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520:RefSeq (mRNA)
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33:
30:
19:
1283:expanding it
1275:chromosome 5
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1253:
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1217:
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1167:
1128:
1124:
1095:
1091:
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1051:
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991:
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938:
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885:
836:
832:
796:(9): 735–9.
793:
789:
763:. Retrieved
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229:
222:
188:160,485,450
175:160,485,352
66:External IDs
29:
998:(7): e610.
688:as part of
670:is a small
44:Identifiers
1322:Categories
765:2012-01-27
728:, May 2017
704:References
263:glomerulus
259:epithelium
233:(ortholog)
1273:on human
682:microRNAs
366:Orthologs
79:GeneCards
1246:30191805
1238:18568019
1208:18474871
1155:18390754
1112:18383392
1082:18057241
1032:17622355
992:PLOS ONE
979:16885212
926:16365291
873:15800047
820:12007417
724:–
643:Wikidata
267:prostate
18:MiR-146a
1199:2438239
1176:Bibcode
1146:2639646
1073:2258704
1023:1905940
1000:Bibcode
970:1567904
947:Bibcode
917:1323209
894:Bibcode
841:Bibcode
798:Bibcode
726:Ensembl
474:UniProt
431:Ensembl
372:Species
208:pattern
83:MIR146A
58:MIR146A
51:Aliases
35:MIR146A
1244:
1236:
1206:
1196:
1153:
1143:
1110:
1080:
1070:
1030:
1020:
977:
967:
924:
914:
871:
864:556237
861:
818:
694:Drosha
690:capped
626:search
624:PubMed
402:406938
388:Entrez
336:BioGPS
291:spleen
255:kidney
167:5q33.3
75:610566
1277:is a
1242:S2CID
381:Mouse
376:Human
283:blood
231:Mouse
224:Human
171:Start
104:Human
1279:stub
1271:gene
1234:PMID
1204:PMID
1151:PMID
1108:PMID
1078:PMID
1028:PMID
975:PMID
922:PMID
869:PMID
816:PMID
676:gene
214:Bgee
162:Band
121:Chr.
71:OMIM
1226:doi
1194:PMC
1184:doi
1172:105
1141:PMC
1133:doi
1129:180
1100:doi
1068:PMC
1060:doi
1018:PMC
1008:doi
965:PMC
955:doi
943:103
912:PMC
902:doi
890:102
859:PMC
849:doi
837:102
806:doi
632:n/a
617:n/a
595:n/a
576:n/a
552:n/a
533:n/a
510:n/a
463:n/a
420:n/a
344:n/a
311:n/a
184:End
87:OMA
1324::
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794:12
792:.
788:.
751:^
741:.
712:^
678:.
190:bp
177:bp
85:;
81::
77:;
73::
1310:e
1303:t
1296:v
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996:2
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851::
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808::
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768:.
745:.
492:a
488:n
106:)
89::
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
