Microphthalmia-associated transcription factor

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For example, it has been uncovered that the DNA of certain genes is often damaged in melanoma cells, most likely as a result of damage from UV radiation, and in turn increases the likelihood of developing melanoma. Specifically, it has been found that a large percentage of melanomas have mutations in the B-RAF gene which leads to melanoma by causing an MEK-ERK kinase cascade when activated. In addition to B-RAF, MITF is also known to play a crucial role in melanoma progression. Since it is a transcription factor that is involved in the regulation of genes related to invasiveness, migration, and metastasis, it can play a role in the progression of melanoma.

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development, a function redundant of MITF. The combined loss of both genes results in severe osteopetrosis, pointing to an interaction between MITF and other members of its transcription factor family. In turn, TFEB has been termed as the master regulator of lysosome biogenesis and autophagy. Interestingly, MITF, TFEB and TFE3 separate roles in modulating starvation-induced autophagy have been described in melanoma. Moreover, MITF and TFEB proteins, directly regulate each other’s mRNA and protein expression while their subcellular localization and transcriptional activity are subject to similar modulation, such as the

304: 281: 178: 203: 555: 310: 209: 31: 1917:) that is recognized, bound and activated by DDX3X. Although, the 5' UTR of MITF only consists of a nucleotide stretch of 123-nt, this region is predicted to fold into energetically favorable RNA secondary structures including multibranched loops and asymmetric bulges that is characteristics of IRES elements. Activation of this 1339:, repair, mitosis, microRNA production, membrane trafficking, mitochondrial metabolism, and much more. Mutation of this gene results in deafness, bone loss, small eyes, and poorly pigmented eyes and skin. In human subjects, because it is known that MITF controls the expression of various genes that are essential for normal 1854:

MITF, TFE3 and TFEB are part of the basic helix-loop-helix-leucine zipper family of transcription factors. Each protein encoded by the family of transcription factors can bind DNA. MITF is necessary for melanocyte and eye development and new research suggests that TFE3 is also required for osteoclast

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production. Ap4A, which is an adenosine joined to another adenosine through a 5‘-5’tetraphosphate bridge, binds to HINT1 and this releases MITF from the inhibitory complex, allowing it to transcribe its target genes. Specifically, Ap4A causes a polymerization of the HINT1 molecule into filaments. The

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Tietz syndrome, first described in 1923, is a congenital disorder often characterized by deafness and leucism. Tietz is caused by a mutation in the MITF gene. The mutation in MITF deletes or changes a single amino acid base pair specifically in the base motif region of the MITF protein. The new MITF

1316:. The term "lineage-specific", since it relates to MITF, means genes or traits that are only found in a certain cell type. Therefore, MITF may be involved in the rewiring of signaling cascades that are specifically required for the survival and physiological function of their normal cell precursors. 1843:

The Myc-associated zinc-finger protein related factor (MAZR) interacts with the Zip domain of MITF. When expressed together, both MAZR and MITF increase promoter activity of the mMCP-6 gene. MAZR and MITF together transactivate the mMCP-6 gene. MAZR also plays a role in the phenotypic expression of

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type 2 enzymatic family (NUDT2), to cleave Ap4A, allow the binding of HINT1 to MITF and thus suppress the expression of the MITF transcribed genes. NUDT2 itself has also been shown to be associated with human breast carcinoma, where it promotes cellular proliferation. The enzyme is 17 kDa large and

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is a ubiquitin conjugating enzyme whose proteins associates with MITF. Although hUBC9 is known to act preferentially with SENTRIN/SUMO1, an in vitro analysis demonstrated greater actual association with MITF. hUBC9 is a critical regulator of melanocyte differentiation. To do this, it targets MITF

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are commonly known as cells that are responsible for producing the pigment melanin which gives coloration to the hair, skin, and nails. The exact mechanisms of how exactly melanocytes become cancerous are relatively unclear, but there is ongoing research to gain more information about the process.

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The functional cooperation between MITF and the lymphoid enhancing factor (LEF-1) results in a synergistic transactivation of the dopachrome tautomerase gene promoter, which is an early melanoblast marker. LEF-1 is involved in the process of regulation by Wnt signaling. LEF-1 also cooperates with

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Protein kinase C-interacting protein 1 (PKC1) associates with MITF. Their association is reduced upon cell activation. When this happens MITF disengages from PKC1. PKC1 by itself, found in the cytosol and nucleus, has no known physiological function. It does, however, have the ability to suppress

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MITF is also an integral part of melanocytes, where it regulates the expression of a number of proteins with melanogenic potential. Continuous expression of MITF at a certain level is one of the necessary factors for melanoma cells to proliferate, survive and avoid detection by host immune cells

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Waardenburg syndrome is a rare genetic disorder. Its symptoms include deafness, minor defects, and abnormalities in pigmentation. Mutations in the MITF gene have been found in certain patients with Waardenburg syndrome, type II. Mutations that change the amino acid sequence of that result in an

1851:'s DNA binding activity. PIAS3 directly interacts with MITF, and STAT3 does not interfere with the interaction between PIAS3 and MITF. PIAS3 functions as a key molecule in suppressing the transcriptional activity of MITF. This is important when considering mast cell and melanocyte development. 1811:

activation signaling. The induction of serine phosphorylation by the frequently altered MAPK/BRAF pathway and the GSK-3 pathway in melanoma regulates MITF nuclear export and thereby decreasing MITF activity in the nucleus. Similarly, tyrosine phosphorylation mediated by the presence of the KIT

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207 in a MAPK-dependent manner. This phosphorylation causes LysRS to change its conformation, detach from the complex and translocate into the nucleus, where it associates with the encoding histidine triad nucleotide–binding protein 1 (HINT1) thus forming the MITF-HINT1 inhibitory complex. The

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protein is unable to bind to DNA and melanocyte development and subsequently melanin production is altered. A reduced number of melanocytes can lead to hearing loss, and decreased melanin production can account for the light skin and hair color that make Tietz syndrome so noticeable.

1697:(LysRS) normally resides in the multisynthetase complex. This complex consists of nine different aminoacyl-tRNA synthetases and three scaffold proteins and has been termed the "signalosome" due to its non-catalytic signalling functions. After activation, LysRS is phosphorylated on 57: 1368:

An understanding of MITF is necessary to understand how certain lineage-specific cancers and other diseases progress. In addition, current and future research can lead to potential avenues to target this transcription factor mechanism for cancer prevention.

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abnormally small MITF are found. These mutations disrupt dimer formation, and as a result cause insufficient development of melanocytes. The shortage of melanocytes causes some of the characteristic features of Waardenburg syndrome.

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phosphorylation. This chain of molecular events leads to two levels of MITF suppression: first, ATF4 protein binds and suppresses MITF transcription and second, eIF2α blocks MITF translation possibly through the inhibition of

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Xu W, Gong L, Haddad MM, Bischof O, Campisi J, Yeh ET, Medrano EE (March 2000). "Regulation of microphthalmia-associated transcription factor MITF protein levels by association with the ubiquitin-conjugating enzyme hUBC9".

1331:, belong to a subfamily of related bHLHZip proteins, termed the MiT-TFE family of transcription factors. The factors are able to form stable DNA-binding homo- and heterodimers. The gene that encodes for MITF resides at the 1707:

polymerization blocks the interface for MITF and thus prevents the binding of the two proteins. This mechanism is dependent on the precise length of the phosphate bridge in the Ap4A molecule so other nucleotides such as

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MITF recognizes E-box (CAYRTG) and M-box (TCAYRTG or CAYRTGA) sequences in the promoter regions of target genes. Known target genes (confirmed by at least two independent sources) of this transcription factor include,

1723:(melan-A). Post-translational modifications of the HINT1 molecules have been shown to affect MITF gene expression as well as the binding of Ap4A. Mutations in HINT1 itself have been shown to be the cause of axonal 1732:

can freely diffuse between the nucleus and cytosol explaining its presence in the nucleus. It has also been shown to be actively transported into the nucleus by directly interacting with the N-terminal domain of

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upon immunological stimulation of the mast cells. Growing evidence is pointing to the fact that the LysRS-Ap4A-MITF signalling pathway is in fact an integral aspect of controlling MITF transcriptional activity.

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Delfgaauw J, Duschl J, Wellbrock C, Froschauer C, Schartl M, Altschmied J (November 2003). "MITF-M plays an essential role in transcriptional activation and signal transduction in Xiphophorus melanoma".

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Motzik A, Amir E, Erlich T, Wang J, Kim BG, Han JM, et al. (August 2017). "Post-translational modification of HINT1 mediates activation of MITF transcriptional activity in human melanoma cells".

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Oka K, Suzuki T, Onodera Y, Miki Y, Takagi K, Nagasaki S, et al. (April 2011). "Nudix-type motif 2 in human breast carcinoma: a potent prognostic factor associated with cell proliferation".

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Lister JA, Robertson CP, Lepage T, Johnson SL, Raible DW (September 1999). "nacre encodes a zebrafish microphthalmia-related protein that regulates neural-crest-derived pigment cell fate".

1828:. Association of MITF with other proteins is a critical step in the regulation of MITF-mediated transcriptional activity. Some commonly studied MITF interactions include those with MAZR, 6331: 3857:

Zimoń M, Baets J, Almeida-Souza L, De Vriendt E, Nikodinovic J, Parman Y, et al. (October 2012). "Loss-of-function mutations in HINT1 cause axonal neuropathy with neuromyotonia".

110:, CMM8, MI, WS2, WS2A, bHLHe32, microphthalmia-associated transcription factor, melanogenesis associated transcription factor, COMMAD, melanocyte inducing transcription factor, MITF-A 4497:"The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate the tartrate-resistant acid phosphatase promoter" 4356:"Interaction and cooperation of mi transcription factor (MITF) and myc-associated zinc-finger protein-related factor (MAZR) for transcription of mouse mast cell protease 6 gene" 3507:

Hou L, Panthier JJ, Arnheiter H (December 2000). "Signaling and transcriptional regulation in the neural crest-derived melanocyte lineage: interactions between KIT and MITF".

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Hemesath TJ, Price ER, Takemoto C, Badalian T, Fisher DE (January 1998). "MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes".

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are also critical activators of MITF phosphorylation. In contrast, tyrosine phosphorylation is induced by the presence of the KIT oncogenic mutation D816V. This KIT

5877: 5548: 3209:"The microphthalmia transcription factor (Mitf) controls expression of the ocular albinism type 1 gene: link between melanin synthesis and melanosome biogenesis" 4438:"Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development" 3256:

Aoki H, Moro O (September 2002). "Involvement of microphthalmia-associated transcription factor (MITF) in expression of human melanocortin-1 receptor (MC1R)".

3111:"Epistatic connections between microphthalmia-associated transcription factor and endothelin signaling in Waardenburg syndrome and other pigmentary disorders" 6371: 2704:"The microphthalmia transcription factor regulates expression of the tartrate-resistant acid phosphatase gene during terminal differentiation of osteoclasts" 10166: 10150: 4969: 2032:

Hershey CL, Fisher DE (April 2004). "Mitf and Tfe3: members of a b-HLH-ZIP transcription factor family essential for osteoclast development and function".

6223: 898: 879: 139: 6008: 6001: 5996: 5984: 5979: 5974: 5969: 5964: 5892: 9888: 6687: 5746: 1874:

MITF-related proteins like TFE3. MITF is a modulator of LEF-1, and this regulation ensures efficient propagation of Wnt signals in many cells.

2014: 1800: 1996: 10342: 9651: 5543: 5115: 2933:"Microphthalmia-associated transcription factor is a critical transcriptional regulator of melanoma inhibitor of apoptosis in melanomas" 1429: 303: 9920: 8819: 6906: 4739:"Suppression of microphthalmia transcriptional activity by its association with protein kinase C-interacting protein 1 in mast cells" 1210: 6364: 6359: 6287: 6277: 5154: 5144: 4979: 1217: 1825: 280: 3544:"Selective down-regulation of tyrosinase family gene TYRP1 by inhibition of the activity of melanocyte transcription factor, MITF" 2221:"Mechanism of conditional partner selectivity in MITF/TFE family transcription factors with a conserved coiled coil stammer motif" 6282: 6196: 4783:"Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma" 1683: 3902:"Diadenosine tetraphosphate hydrolase is part of the transcriptional regulation network in immunologically activated mast cells" 9218: 6494: 6484: 5085: 4964: 1983: 1962: 10347: 6849: 6489: 6184: 3994:"Importin beta plays an essential role in the regulation of the LysRS-Ap(4)A pathway in immunologically activated mast cells" 3675:"The function of lysyl-tRNA synthetase and Ap4A as signaling regulators of MITF activity in FcepsilonRI-activated mast cells" 2219:

Pogenberg V, Ballesteros-Álvarez J, Schober R, Sigvaldadóttir I, Obarska-Kosinska A, Milewski M, et al. (January 2020).

1910: 1541: 1979: 3427:"The gene encoding the T-box factor Tbx2 is a target for the microphthalmia-associated transcription factor in melanocytes" 202: 177: 54: 10131: 10126: 9277: 6189: 4878: 1870:

MITF transcriptional activity and can function as an in vivo negative regulator of MITF induced transcriptional activity.

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of MITF is still an unexplored area with only two peer-reviewed papers (as of 2019) highlighting the importance. During

119: 8731: 8726: 8277: 6354: 6272: 6260: 5336: 3593:"Hierarchical network between the components of the multi-tRNA synthetase complex: implications for complex formation" 1720: 4143:"c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi" 3468:"Transcriptional regulation of the melanoma prognostic marker melastatin (TRPM1) by MITF in melanocytes and melanoma" 1764:

on several serine and tyrosine residues. Serine phosphorylation is regulated by several signaling pathways including

316: 215: 6467: 5465: 3345:"Microphthalmia-associated transcription factor regulates RAB27A gene expression and controls melanosome transport" 1466: 2892:"VMD2 promoter requires two proximal E-box sites for its activity in vivo and is regulated by the MITF-TFE family" 1744:

has been confirmed in cardiomyocytes. A heart specific isoform of MITF is a major regulator of cardiac growth and

9883: 6764: 6749: 6732: 6727: 6722: 6717: 6628: 6603: 6479: 6391: 6381: 5538: 5011: 1788: 1694: 1451: 309: 208: 2974:"Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF" 2843:"Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability" 10352: 9625: 9260: 8776: 8349: 8188: 7123: 7118: 7103: 6578: 6553: 6435: 6386: 6179: 5570: 5036: 4882: 1882: 1769: 943: 127: 4238:"C-KIT signaling depends on microphthalmia-associated transcription factor for effects on cell proliferation" 2115:"microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family" 10357: 9990: 8031: 7348: 6462: 6450: 2067:

Garraway LA, Sellers WR (August 2006). "Lineage dependency and lineage-survival oncogenes in human cancer".

1761: 1727:. The regulatory mechanism relies on the enzyme diadenosine tetraphosphate hydrolase, a member of the 1483: 924: 4642:

Möller K, Sigurbjornsdottir S, Arnthorsson AO, Pogenberg V, Dilshat R, Fock V, et al. (January 2019).

4197:"D816V Induces SRC-Mediated Tyrosine Phosphorylation of MITF and Altered Transcription Program in Melanoma" 2638: 1686:

is activated upon allergen stimulation. The binding of immunoglobulin E to the high-affinity IgE receptor (

10121: 8168: 8163: 6558: 6455: 6250: 6211: 5274: 4923: 2489:"The complex relationship between MITF and the immune system: a Melanoma ImmunoTherapy (response) Factor?" 1918: 1708: 1461: 1295: 2113:

Hemesath TJ, Steingrímsson E, McGill G, Hansen MJ, Vaught J, Hodgkinson CA, et al. (November 1994).

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Falletta P, Sanchez-Del-Campo L, Chauhan J, Effern M, Kenyon A, Kershaw CJ, et al. (January 2017).

3018:"The expression of Clcn7 and Ostm1 in osteoclasts is coregulated by microphthalmia transcription factor" 1724: 3296:"MLANA/MART1 and SILV/PMEL17/GP100 are transcriptionally regulated by MITF in melanocytes and melanoma" 2792:

Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, et al. (December 2008).

9694: 9686: 7524: 7006: 6531: 6526: 6521: 6201: 6084: 4919: 4655: 4557: 4449: 4308: 4249: 4099: 3772: 3763:

Gray-Schopfer V, Wellbrock C, Marais R (February 2007). "Melanoma biology and new targeted therapy".

2170: 2157:

Ballesteros-Álvarez J, Dilshat R, Fock V, Möller K, Karl L, Larue L, et al. (3 September 2020).

1550: 1387: 1348: 1301: 191: 4888: 4603:"Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways" 106: 10008: 9712: 9408: 7611: 6816: 6398: 6376: 6349: 6311: 6245: 4436:

Steingrimsson E, Tessarollo L, Pathak B, Hou L, Arnheiter H, Copeland NG, Jenkins NA (April 2002).

3386:"Identification of Aim-1 as the underwhite mouse mutant and its transcriptional regulation by MITF" 1804: 1749: 1189: 1185: 1164: 1160: 1156: 1152: 1148: 1118: 1114: 1086: 1082: 1061: 1057: 1053: 1049: 1045: 1015: 1011: 4544:

Sardiello M, Palmieri M, di Ronza A, Medina DL, Valenza M, Gennarino VA, et al. (July 2009).

3062:"Microphthalmia-associated transcription factor interacts with LEF-1, a mediator of Wnt signaling" 9546: 4583: 4526: 4236:

Phung B, Sun J, Schepsky A, Steingrimsson E, Rönnstrand L (24 August 2011). Capogrossi MC (ed.).

4123: 3974: 3882: 3839: 3796: 3140: 2872: 2823: 2733: 2342: 2092: 151: 4195:

Phung B, Kazi JU, Lundby A, Bergsteinsdottir K, Sun J, Goding CR, et al. (September 2017).

1193: 1144: 1140: 1136: 1126: 1122: 1110: 1090: 1041: 1037: 1033: 1023: 1019: 1007: 4837:"The X-Linked DDX3X RNA Helicase Dictates Translation Reprogramming and Metastasis in Melanoma" 4397:"A new role for the STAT3 inhibitor, PIAS3: a repressor of microphthalmia transcription factor" 4141:

Wu M, Hemesath TJ, Takemoto CM, Horstmann MA, Wells AG, Price ER, et al. (February 2000).

3634:"LysRS serves as a key signaling molecule in the immune response by regulating gene expression" 9128: 9119: 8756: 7704: 6445: 6440: 4858: 4812: 4760: 4737:

Razin E, Zhang ZC, Nechushtan H, Frenkel S, Lee YN, Arudchandran R, Rivera J (November 1999).

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McGill GG, Horstmann M, Widlund HR, Du J, Motyckova G, Nishimura EK, et al. (June 2002).

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Mansky KC, Sulzbacher S, Purdom G, Nelsen L, Hume DA, Rehli M, Ostrowski MC (February 2002).

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Loftus SK, Antonellis A, Matera I, Renaud G, Baxter LL, Reid D, et al. (February 2009).

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Ngeow KC, Friedrichsen HJ, Li L, Zeng Z, Andrews S, Volpon L, et al. (September 2018).

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Sato-Jin K, Nishimura EK, Akasaka E, Huber W, Nakano H, Miller A, et al. (April 2008).

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Du J, Widlund HR, Horstmann MA, Ramaswamy S, Ross K, Huber WE, et al. (December 2004).

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Ascierto PA, Kirkwood JM, Grob JJ, Simeone E, Grimaldi AM, Maio M, et al. (July 2012).

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Phung B, Cieśla M, Sanna A, Guzzi N, Beneventi G, Cao Thi Ngoc P, et al. (June 2019).

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Carmi-Levy I, Motzik A, Ofir-Birin Y, Yagil Z, Yang CM, Kemeny DM, et al. (May 2011).

2637:"Melanoma Skin Cancer. " American Cancer Society, 29. Oct. 2014. Web. 15 October 2014. < 1840:. Looking at the variety of structures gives insight into MITF's varied roles in the cell. 9796: 9019: 8889: 8255: 8213: 8208: 8203: 8141: 8053: 7975: 7763: 7714: 7709: 5756: 4041:

Tshori S, Gilon D, Beeri R, Nechushtan H, Kaluzhny D, Pikarsky E, Razin E (October 2006).

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Yannay-Cohen N, Carmi-Levy I, Kay G, Yang CM, Han JM, Kemeny DM, et al. (June 2009).

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Vetrini F, Auricchio A, Du J, Angeletti B, Fisher DE, Ballabio A, Marigo V (August 2004).

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As mentioned above, changes in MITF can result in serious health conditions. For example,

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transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

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Palmieri M, Impey S, Kang H, di Ronza A, Pelz C, Sardiello M, Ballabio A (October 2011).

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conformational change also switches LysRS activity from aminoacylation of Lysine tRNA to

4659: 4561: 4453: 4312: 4253: 4103: 3776: 3716:"4A polymerizes target protein HINT1 to transduce signals in FcεRI-activated mast cells" 2174: 9893: 8173: 8156: 6299: 5954: 4951: 4807: 4782: 4678: 4643: 4331: 4296: 4272: 4237: 4067: 4042: 4018: 3993: 3926: 3901: 3740: 3715: 3320: 3295: 3184: 3159: 2702:

Luchin A, Purdom G, Murphy K, Clark MY, Angel N, Cassady AI, et al. (March 2000).

2679: 2652: 2615: 2590: 2566: 2539: 2515: 2488: 2247: 2220: 2193: 2158: 1935: 1930: 1813: 1391: 1352: 1298: 4472: 4437: 4167: 4142: 3691: 3674: 3568: 3543: 3311: 3269: 3233: 3208: 3086: 3061: 3016:

Meadows NA, Sharma SM, Faulkner GJ, Ostrowski MC, Hume DA, Cassady AI (January 2007).

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locus in mice, and its protumorogenic targets include factors involved in cell death,

813: 808: 803: 798: 793: 788: 783: 778: 773: 768: 763: 758: 753: 748: 743: 738: 733: 728: 723: 718: 713: 708: 703: 698: 693: 688: 672: 667: 662: 646: 641: 631: 626: 621: 616: 611: 606: 601: 596: 10336: 8751: 8091: 6516: 6304: 5632: 3886: 3224: 3175: 2810: 2793: 2329: 2312: 1626: 583: 4587: 4530: 4127: 3978: 3144: 2876: 2827: 2737: 2346: 2313:"Fifteen-year quest for microphthalmia-associated transcription factor target genes" 2096: 779:

canonical Wnt signaling pathway involved in negative regulation of apoptotic process

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Chiaverini C, Beuret L, Flori E, Busca R, Abbe P, Bille K, et al. (May 2008).

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Yasumoto K, Takeda K, Saito H, Watanabe K, Takahashi K, Shibahara S (June 2002).

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involved in lineage-specific pathway regulation of many types of cells including

155: 9985: 9588: 8068: 7783: 7748: 6137: 5942: 5937: 5380: 5184: 5179: 5075: 4955: 4644:"MITF has a central role in regulating starvation-induced autophagy in melanoma" 2405:. National Institutes of Health, U.S. Department of Health & Human Services. 2019:

National Center for Biotechnology Information, U.S. National Library of Medicine

2001:

National Center for Biotechnology Information, U.S. National Library of Medicine

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Proceedings of the National Academy of Sciences of the United States of America

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Proceedings of the National Academy of Sciences of the United States of America

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Du J, Miller AJ, Widlund HR, Horstmann MA, Ramaswamy S, Fisher DE (July 2003).

3077: 2720: 2703: 2505: 2045: 472: 10297: 10248: 9720: 9324: 9233: 9213: 9186: 8533: 8282: 8131: 8119: 8114: 7113: 7108: 5872: 5867: 5845: 5711: 5529: 5233: 5174: 5169: 5149: 2990: 2973: 2272:"A helix-loop-helix transcription factor-like gene is located at the mi locus" 1679: 1527: 1313: 288: 185: 135: 4755: 4738: 3900:

Carmi-Levy I, Yannay-Cohen N, Kay G, Razin E, Nechushtan H (September 2008).

2556: 10171: 10161: 10144: 9618: 8637: 6342: 5771: 5429: 4570: 4545: 4321: 3520: 3466:

Miller AJ, Du J, Rowan S, Hershey CL, Widlund HR, Fisher DE (January 2004).

2669: 2429: 1886: 1383: 1356: 1355:. Its function is conserved across vertebrates, including in fishes such as 843: 532: 410: 355: 342: 254: 241: 143: 4862: 4816: 4798: 4764: 4723: 4715: 4687: 4628: 4579: 4522: 4481: 4462: 4422: 4413: 4396: 4381: 4372: 4355: 4340: 4281: 4222: 4176: 4076: 4027: 3970: 3935: 3878: 3835: 3792: 3749: 3700: 3659: 3618: 3609: 3592: 3577: 3528: 3493: 3452: 3443: 3426: 3411: 3402: 3385: 3370: 3361: 3344: 3329: 3277: 3242: 3193: 3136: 3095: 3043: 3034: 3017: 2999: 2958: 2917: 2908: 2891: 2868: 2819: 2729: 2688: 2624: 2575: 2524: 2473: 2437: 2338: 2256: 2202: 2088: 2053: 4119: 3714:

Yu J, Liu Z, Liang Y, Luo F, Zhang J, Tian C, et al. (October 2019).

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Han JM, Lee MJ, Park SG, Lee SH, Razin E, Choi EC, Kim S (December 2006).

3127: 3110: 2381: 2297: 2237: 2140: 2131: 2114: 1257: 1252: 636: 30: 9638: 9416: 7778: 6337: 6294: 5346: 4619: 4602: 4513: 4496: 4158: 4009: 3917: 3559: 2606: 1824:

Most transcription factors function in cooperation with other factors by

1733: 1555: 1344: 1343:

synthesis in melanocytes, mutations of MITF can lead to diseases such as

1241: 988: 969: 3827: 3784: 2794:"Novel MITF targets identified using a two-step DNA microarray strategy" 2639:

http://www.cancer.org/acs/groups/cid/documents/webcontent/003120-pdf.pdf

627:

DNA-binding transcription activator activity, RNA polymerase II-specific

617:

DNA-binding transcription repressor activity, RNA polymerase II-specific

10038: 10018: 10013: 9725: 7699: 7483: 5395: 5390: 5385: 5373: 5368: 4297:"BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export" 2591:"Tietz syndrome (hypopigmentation/deafness) caused by mutation of MITF" 1905:

MITF can also be directly translationally modified by the RNA helicase

1748:

responsible for heart growth and for the physiological response of the

1510: 1340: 1281: 955: 910: 3962: 2540:"Waardenburg syndrome: A rare genetic disorder, a report of two cases" 76: 10219: 10214: 10209: 10199: 10194: 9913: 9468: 9463: 9458: 9453: 8719: 8714: 8591: 8586: 8581: 8566: 8557: 8552: 8547: 8526: 8440: 8435: 8223: 8218: 8198: 8193: 8183: 8178: 8016: 7968: 7963: 7958: 7953: 7923: 7918: 7913: 7908: 7878: 7828: 7823: 7586: 7506: 7478: 7473: 7468: 7463: 7458: 7453: 7448: 7443: 7438: 7433: 7428: 7423: 7418: 7413: 7408: 7403: 7398: 7393: 7383: 7378: 7373: 7368: 7363: 7358: 7353: 7343: 7338: 7333: 7293: 7246: 7241: 7236: 7231: 7226: 7221: 7211: 7199: 7194: 6960: 6955: 6950: 6832: 6827: 6799: 6794: 6779: 6774: 6769: 6759: 6754: 6742: 6737: 6109: 6104: 6099: 6094: 6089: 6064: 5991: 5959: 5902: 5897: 5684: 5679: 5674: 5558: 5363: 5253: 5248: 5221: 5216: 5211: 5137: 4058: 2931:

Dynek JN, Chan SM, Liu J, Zha J, Fairbrother WJ, Vucic D (May 2008).

1899: 1784: 1716: 1698: 1653: 1638: 1616: 1609: 1599: 1587: 1577: 1500: 1478: 1225: 865: 647:

DNA-binding transcription factor activity, RNA polymerase II-specific

622:

RNA polymerase II cis-regulatory region sequence-specific DNA binding

4043:"Transcription factor MITF regulates cardiac growth and hypertrophy" 3870: 2398: 2080: 1893:

transcripts increases as well as the translation of the mRNA due to

4354:

Morii E, Oboki K, Kataoka TR, Igarashi K, Kitamura Y (March 2002).

10263: 10241: 10236: 10204: 10093: 10088: 10033: 10028: 10023: 9967: 9876: 9871: 9866: 9861: 9856: 9851: 9846: 9841: 9789: 9784: 9772: 9767: 9762: 9757: 9745: 9740: 9735: 9730: 9699: 9666: 9661: 9656: 9603: 9598: 9593: 9568: 9526: 9521: 9516: 9511: 9506: 9501: 9473: 9426: 9421: 9367: 9362: 9357: 9352: 9329: 9104: 9089: 9084: 9079: 9074: 9069: 9064: 9059: 9054: 9049: 9039: 9029: 9024: 9009: 9004: 8994: 8989: 8984: 8974: 8969: 8964: 8959: 8954: 8949: 8944: 8914: 8909: 8899: 8894: 8879: 8874: 8869: 8864: 8798: 8793: 8788: 8761: 8736: 8704: 8697: 8692: 8598: 8576: 8571: 8543: 8521: 8516: 8511: 8506: 8401: 8396: 8341: 8334: 8329: 8314: 8287: 7948: 7943: 7938: 7933: 7928: 7903: 7898: 7893: 7888: 7883: 7873: 7868: 7863: 7858: 7853: 7848: 7843: 7838: 7833: 7813: 7808: 7803: 7798: 7793: 7788: 7773: 7768: 7593: 7581: 7576: 7571: 7566: 7534: 7529: 7328: 7318: 7313: 7308: 7303: 7298: 7288: 7283: 7278: 7273: 7189: 7179: 7172: 7167: 7162: 7157: 7147: 7091: 7086: 7081: 7076: 7071: 7066: 7061: 6982: 6977: 6972: 6916: 6911: 6810: 6789: 6784: 6658: 6653: 6648: 6643: 6638: 6633: 5840: 5605: 5600: 5595: 5585: 5580: 5575: 5565: 5553: 5503: 5483: 5424: 5412: 5407: 5331: 5324: 5319: 5309: 5302: 5297: 5228: 5159: 5132: 5127: 5110: 5105: 5100: 5095: 5090: 5080: 5068: 5063: 5041: 5031: 5026: 5016: 4111: 2360:

Moore KJ (November 1995). "Insight into the microphthalmia gene".

1906: 1894: 1862: 1848: 1829: 1776: 1772: 1687: 1648: 1631: 1604: 1594: 1582: 1532: 1522: 1495: 1488: 1473: 1456: 1444: 1439: 1434: 2270:

Hughes MJ, Lingrel JB, Krakowsky JM, Anderson KP (October 1993).

1544:

study (which confirmed the above targets) include the following,

828: 824: 10290: 10285: 10280: 10270: 10258: 10253: 10100: 10083: 9947: 9942: 9937: 9908: 9903: 9836: 9831: 9826: 9821: 9816: 9811: 9806: 9801: 9752: 9646: 9608: 9583: 9578: 9573: 9556: 9448: 9441: 9436: 9317: 9312: 9307: 9302: 9297: 9292: 9287: 9282: 9272: 9265: 9255: 9250: 9238: 9228: 9223: 9206: 9201: 9196: 9179: 9174: 9169: 9144: 9139: 9134: 8852: 8847: 8842: 8837: 8832: 8771: 8746: 8741: 8682: 8677: 8672: 8667: 8662: 8657: 8652: 8647: 8642: 8613: 8608: 8501: 8496: 8491: 8486: 8472: 8467: 8462: 8457: 8452: 8423: 8418: 8413: 8379: 8374: 8369: 8364: 8359: 8354: 8319: 8307: 8302: 8297: 8250: 8245: 8240: 8235: 8230: 8151: 8136: 8126: 8102: 8097: 8083: 8078: 8073: 8063: 8058: 8046: 8041: 7985: 7980: 7758: 7743: 7738: 7726: 7721: 7554: 7549: 7544: 7388: 7323: 7268: 7263: 7258: 7142: 7137: 7132: 7056: 7051: 7046: 7041: 7036: 7031: 7026: 7021: 7016: 6999: 6994: 6938: 6933: 6901: 6896: 6891: 6881: 6876: 6869: 6864: 6859: 6854: 6844: 6839: 6822: 6680: 6675: 6670: 6598: 6059: 6054: 6049: 6044: 6039: 6034: 5947: 5932: 5909: 5882: 5855: 5850: 5815: 5793: 5788: 5783: 5766: 5761: 5751: 5741: 5691: 5649: 5644: 5627: 5622: 5617: 5515: 5510: 5498: 5456: 5451: 5441: 5356: 5351: 5341: 5260: 5243: 5206: 5194: 5189: 5164: 5122: 5051: 5046: 5021: 5004: 4999: 4994: 4989: 4984: 4974: 1890: 1856: 1837: 1833: 1780: 1703: 1643: 1560: 1517: 1505: 1328: 1324: 1320: 1288: 123: 10061: 9390: 7632: 6132: 4934: 4892: 563: 9932: 9561: 9551: 9431: 8827: 8384: 7733: 7184: 6921: 6415: 5887: 5716: 5706: 5701: 5493: 5488: 704:

positive regulation of DNA-templated transcription, initiation

4546:"A gene network regulating lysosomal biogenesis and function" 2311:

Cheli Y, Ohanna M, Ballotti R, Bertolotto C (February 2010).

1847:

PIAS3 is a transcriptional inhibiter that acts by inhibiting

2890:

Esumi N, Kachi S, Campochiaro PA, Zack DJ (January 2007).

799:

positive regulation of transcription by RNA polymerase II

699:

negative regulation of transcription by RNA polymerase II

3673:

Lee YN, Nechushtan H, Figov N, Razin E (February 2004).

1740:

Activation of the LysRS-Ap4A-MITF signalling pathway by

379: 3160:"Gpnmb is a melanoblast-expressed, MITF-dependent gene" 2589:

Smith SD, Kelley PM, Kenyon JB, Hoover D (June 2000).

1816:

also increases the presence of MITF in the cytoplasm.

1921:

by DDX3X promotes MITF expression in melanoma cells.

544: 10180: 10140: 10109: 10074: 9999: 9976: 9958: 9708: 9682: 9634: 9537: 9484: 9404: 9338: 9155: 9115: 8811: 8628: 8268: 7994: 7682: 7663: 7651: 7602: 7515: 7494: 6696: 6616: 6587: 6567: 6542: 6505: 6424: 6320: 6168: 6149: 6075: 6020: 5918: 5828: 5804: 5727: 5660: 5524: 5474: 5283: 5269: 4947: 2487:Ballotti R, Cheli Y, Bertolotto C (December 2020). 1682:, in which, the A mitogen-activated protein kinase 1178: 1109: 1075: 1006: 794:

positive regulation of transcription, DNA-templated

2159:"MITF and TFEB cross-regulation in melanoma cells" 1975: 1973: 1971: 1954: 1952: 1950: 1690:) provides the stimulus that starts the cascade. 1678:A-MITF signaling pathway was first discovered in 326: 225: 2787: 2785: 2783: 2781: 2779: 2777: 2775: 2773: 2771: 2769: 2767: 1913:of MITF contains important regulatory elements ( 694:regulation of transcription by RNA polymerase II 3289: 3287: 3055: 3053: 3011: 3009: 2765: 2763: 2761: 2759: 2757: 2755: 2753: 2751: 2749: 2747: 4879:Microphthalmia-associated+transcription+factor 4395:Levy C, Nechushtan H, Razin E (January 2002). 1980:GRCm38: Ensembl release 89: ENSMUSG00000035158 1270:Microphthalmia-associated transcription factor 10323:transcription factor/coregulator deficiencies 9394:β-Scaffold factors with minor groove contacts 4904: 1319:MITF, together with transcription factor EB ( 8: 2653:"The role of BRAF V600 mutation in melanoma" 1959:GRCh38: Ensembl release 89: ENSG00000187098 759:regulation of cell population proliferation 10071: 10058: 9401: 9387: 7679: 7660: 7648: 7629: 6165: 6146: 6129: 5280: 4944: 4931: 4911: 4897: 4889: 3425:Carreira S, Liu B, Goding CR (July 2000). 1106: 1003: 839: 729:regulation of transcription, DNA-templated 579: 441:Skeletal muscle tissue of rectus abdominis 367: 266: 163: 65: 4881:at the U.S. National Library of Medicine 4852: 4806: 4754: 4677: 4667: 4618: 4569: 4512: 4471: 4461: 4412: 4371: 4330: 4320: 4271: 4261: 4212: 4166: 4066: 4017: 3925: 3739: 3690: 3649: 3608: 3567: 3542:Fang D, Tsuji Y, Setaluri V (July 2002). 3483: 3442: 3401: 3360: 3319: 3232: 3183: 3126: 3085: 3033: 2989: 2948: 2907: 2858: 2809: 2719: 2678: 2668: 2614: 2565: 2555: 2514: 2504: 2328: 2287: 2246: 2236: 2192: 2182: 2130: 1274:class E basic helix-loop-helix protein 32 607:DNA-binding transcription factor activity 1546: 1425: 789:regulation of osteoclast differentiation 769:negative regulation of apoptotic process 425:Skeletal muscle tissue of biceps brachii 1946: 2393: 2391: 719:positive regulation of gene expression 689:regulation of RNA biosynthetic process 20: 4830: 4828: 4826: 4776: 4774: 4190: 4188: 4186: 4047:The Journal of Clinical Investigation 1844:mast cells in association with MITF. 1386:of MITF have been implicated in both 814:negative regulation of cell migration 331: 292: 287: 230: 189: 184: 7: 3164:Pigment Cell & Melanoma Research 2798:Pigment Cell & Melanoma Research 2708:Journal of Bone and Mineral Research 2317:Pigment Cell & Melanoma Research 2214: 2212: 2152: 2150: 2108: 2106: 6077:(1.6) Basic helix-span-helix (bHSH) 4743:The Journal of Biological Chemistry 4401:The Journal of Biological Chemistry 4360:The Journal of Biological Chemistry 3597:The Journal of Biological Chemistry 3431:The Journal of Biological Chemistry 3390:The Journal of Biological Chemistry 3349:The Journal of Biological Chemistry 3022:The Journal of Biological Chemistry 2896:The Journal of Biological Chemistry 2276:The Journal of Biological Chemistry 809:protein-containing complex assembly 1175: 1072: 979: 960: 934: 915: 889: 870: 724:transcription by RNA polymerase II 714:multicellular organism development 549: 467: 405: 384: 14: 3300:The American Journal of Pathology 2657:Journal of Translational Medicine 1704:diadenosine tetraphosphate (Ap4A) 1540:Additional genes identified by a 1284:that in humans is encoded by the 16:Mammalian protein found in humans 3384:Du J, Fisher DE (January 2002). 3225:10.1128/MCB.24.15.6550-6559.2004 3176:10.1111/j.1755-148X.2008.00518.x 2811:10.1111/j.1755-148X.2008.00505.x 2544:Indian Journal of Human Genetics 2330:10.1111/j.1755-148X.2009.00653.x 1752:to beta-adrenergic stimulation. 553: 315: 308: 302: 279: 214: 207: 201: 176: 29: 10064:(0) Other transcription factors 9348:transcriptional enhancer factor 4965:Activating transcription factor 3951:International Journal of Cancer 3998:Molecular and Cellular Biology 3906:Molecular and Cellular Biology 3213:Molecular and Cellular Biology 564:More reference expression data 533:More reference expression data 1: 9278:Interferon regulatory factors 7517:(2.5) Alternating composition 6713:General transcription factors 4214:10.1158/1541-7786.MCR-17-0149 3692:10.1016/S1074-7613(04)00020-2 3485:10.1158/0008-5472.CAN-03-2440 3312:10.1016/S0002-9440(10)63657-7 3270:10.1016/S0024-3205(02)01996-3 2950:10.1158/0008-5472.CAN-07-6622 2860:10.1016/S0092-8674(02)00762-6 2466:10.1016/s0378-1119(03)00817-5 2374:10.1016/s0168-9525(00)89143-x 2289:10.1016/S0021-9258(19)36830-9 1889:starvation of melanoma cells 734:regulation of gene expression 602:protein dimerization activity 300: 199: 8563:Octamer transcription factor 5271:(1.2) Basic helix-loop-helix 4854:10.1016/j.celrep.2019.05.069 4501:Journal of Leukocyte Biology 4263:10.1371/journal.pone.0024064 3651:10.1016/j.molcel.2009.05.019 2184:10.1371/journal.pone.0238546 1866:for proteasome degradation. 1826:protein–protein interactions 709:transcription, DNA-templated 503:Epithelium of choroid plexus 449:myocardium of left ventricle 10343:Genes on human chromosome 3 5337:Myogenic regulatory factors 2595:Journal of Medical Genetics 2538:Kumar S, Rao K (May 2012). 1721:melanoma-associated antigen 1711:or AMP will not affect it. 764:camera-type eye development 10374: 4704:Experimental Cell Research 4669:10.1038/s41598-018-37522-6 3732:10.1038/s41467-019-12710-8 2721:10.1359/jbmr.2000.15.3.451 2506:10.1186/s12943-020-01290-7 2046:10.1016/j.bone.2003.08.014 754:melanocyte differentiation 749:osteoclast differentiation 673:protein-containing complex 507:retinal pigment epithelium 421:retinal pigment epithelium 10318: 10070: 10057: 9400: 9386: 9157:(3.5) Tryptophan clusters 7647: 7628: 6145: 6128: 4943: 4930: 4201:Molecular Cancer Research 2991:10.1016/j.ccr.2004.10.014 2015:"Mouse PubMed Reference:" 1997:"Human PubMed Reference:" 1564: 1559: 1554: 1549: 1443: 1438: 1433: 1428: 1256: 1251: 1247: 1240: 1224: 1205: 1182: 1133: 1102: 1079: 1030: 999: 986: 982: 967: 963: 954: 941: 937: 922: 918: 909: 896: 892: 877: 873: 864: 849: 842: 838: 822: 582: 578: 561: 552: 543: 530: 479: 470: 417: 408: 378: 370: 366: 349: 336: 299: 278: 269: 265: 248: 235: 198: 175: 166: 162: 117: 114: 104: 97: 92: 73: 68: 51: 46: 41: 37: 28: 23: 9978:(4.10) Cold-shock domain 4883:Medical Subject Headings 4756:10.1074/jbc.274.48.34272 4607:Human Molecular Genetics 3078:10.1093/emboj/21.11.2703 2557:10.4103/0971-6866.100804 1919:cis-regulatory sequences 1883:Translational regulation 1878:Translational regulation 1770:receptor tyrosine kinase 1666:A-MITF signaling pathway 4924:intracellular receptors 4787:Genes & Development 4571:10.1126/science.1174447 4322:10.1073/pnas.1810498115 4147:Genes & Development 3521:10.1242/dev.127.24.5379 2670:10.1186/1479-5876-10-85 2430:10.1242/dev.126.17.3757 2403:Genetics Home Reference 2119:Genes & Development 1783:. In addition, several 1211:Chr 3: 69.74 – 69.97 Mb 445:vastus lateralis muscle 4799:10.1101/gad.290940.116 4716:10.1006/excr.2000.4803 4463:10.1073/pnas.072071099 4414:10.1074/jbc.M109236200 4373:10.1074/jbc.M110392200 3610:10.1074/jbc.M605211200 3548:Nucleic Acids Research 3444:10.1074/jbc.M000035200 3403:10.1074/jbc.M110229200 3362:10.1074/jbc.M800130200 3035:10.1074/jbc.M608572200 2909:10.1074/jbc.M609517200 2225:Nucleic Acids Research 2069:Nature Reviews. Cancer 1296:basic helix-loop-helix 519:atrioventricular valve 10348:Transcription factors 9687:TATA-binding proteins 4920:Transcription factors 3720:Nature Communications 3128:10.1096/fj.07-9080com 2132:10.1101/gad.8.22.2770 1373:Clinical significance 739:Wnt signaling pathway 4847:(12): 3573–3586.e7. 4514:10.1189/jlb.71.2.304 4159:10.1101/gad.14.3.301 4010:10.1128/MCB.01159-10 3918:10.1128/MCB.00106-08 2607:10.1136/jmg.37.6.446 1388:Waardenburg syndrome 1349:Waardenburg syndrome 1302:transcription factor 1218:Chr 6: 97.78 – 98 Mb 784:cell fate commitment 744:cell differentiation 333:6 D3|6 45.05 cM 294:Chromosome 6 (mouse) 192:Chromosome 3 (human) 69:List of PDB id codes 42:Available structures 10182:(0.6) Miscellaneous 9713:High-mobility group 9409:Rel homology region 6399:Testicular receptor 6140:DNA-binding domains 4660:2019NatSR...9.1055M 4562:2009Sci...325..473S 4454:2002PNAS...99.4477S 4313:2018PNAS..115E8668N 4307:(37): E8668–E8677. 4254:2011PLoSO...624064P 4104:1998Natur.391..298H 3828:10.1038/onc.2017.81 3785:10.1038/nature05661 3777:2007Natur.445..851G 2238:10.1093/nar/gkz1104 2175:2020PLoSO..1538546B 1859:signaling pathway. 1836:, hUBC9, PKC1, and 1812:oncogenic mutation 1719:recognition of the 9547:p53 p63 p73 family 9120:Heat shock factors 4648:Scientific Reports 4620:10.1093/hmg/ddr306 3560:10.1093/nar/gkf424 2362:Trends in Genetics 1809:SRC protein family 944:ENSMUSG00000035158 682:Biological process 656:Cellular component 590:Molecular function 10330: 10329: 10314: 10313: 10310: 10309: 10053: 10052: 10049: 10048: 9382: 9381: 9378: 9377: 8624: 8623: 8264: 8263: 7624: 7623: 7620: 7619: 6612: 6611: 6468:Mineralocorticoid 6124: 6123: 6120: 6119: 5824: 5823: 4937:(1) Basic domains 4098:(6664): 298–301. 3963:10.1002/ijc.25505 3822:(33): 4732–4738. 1659: 1658: 1538: 1537: 1267: 1266: 1263: 1262: 1236: 1235: 1201: 1200: 1172: 1171: 1098: 1097: 1069: 1068: 995: 994: 976: 975: 950: 949: 931: 930: 905: 904: 886: 885: 834: 833: 632:chromatin binding 574: 573: 570: 569: 539: 538: 526: 525: 464: 463: 362: 361: 261: 260: 88: 87: 84: 83: 52:Ortholog search: 10365: 10154:-related factors 10072: 10059: 9960:(4.9) Grainyhead 9402: 9388: 9340:(3.6) TEA domain 8630:(3.2) Paired box 8271: 8005: 7999: 7693: 7687: 7680: 7676: 7670: 7661: 7649: 7638:Helix-turn-helix 7630: 6592: 6572: 6547: 6510: 6480:Estrogen related 6429: 6325: 6173: 6166: 6154:Nuclear receptor 6147: 6130: 5809: 5730: 5663: 5532: 5477: 5286: 5281: 4945: 4932: 4913: 4906: 4899: 4890: 4867: 4866: 4856: 4832: 4821: 4820: 4810: 4778: 4769: 4768: 4758: 4734: 4728: 4727: 4698: 4692: 4691: 4681: 4671: 4639: 4633: 4632: 4622: 4598: 4592: 4591: 4573: 4541: 4535: 4534: 4516: 4492: 4486: 4485: 4475: 4465: 4433: 4427: 4426: 4416: 4392: 4386: 4385: 4375: 4351: 4345: 4344: 4334: 4324: 4292: 4286: 4285: 4275: 4265: 4233: 4227: 4226: 4216: 4207:(9): 1265–1274. 4192: 4181: 4180: 4170: 4138: 4132: 4131: 4087: 4081: 4080: 4070: 4059:10.1172/JCI27643 4038: 4032: 4031: 4021: 3989: 3983: 3982: 3946: 3940: 3939: 3929: 3897: 3891: 3890: 3854: 3848: 3847: 3811: 3805: 3804: 3760: 3754: 3753: 3743: 3711: 3705: 3704: 3694: 3670: 3664: 3663: 3653: 3629: 3623: 3622: 3612: 3588: 3582: 3581: 3571: 3554:(14): 3096–106. 3539: 3533: 3532: 3504: 3498: 3497: 3487: 3463: 3457: 3456: 3446: 3422: 3416: 3415: 3405: 3381: 3375: 3374: 3364: 3355:(18): 12635–42. 3340: 3334: 3333: 3323: 3291: 3282: 3281: 3253: 3247: 3246: 3236: 3204: 3198: 3197: 3187: 3155: 3149: 3148: 3130: 3106: 3100: 3099: 3089: 3066:The EMBO Journal 3057: 3048: 3047: 3037: 3013: 3004: 3003: 2993: 2969: 2963: 2962: 2952: 2928: 2922: 2921: 2911: 2887: 2881: 2880: 2862: 2838: 2832: 2831: 2813: 2789: 2742: 2741: 2723: 2699: 2693: 2692: 2682: 2672: 2648: 2642: 2635: 2629: 2628: 2618: 2586: 2580: 2579: 2569: 2559: 2535: 2529: 2528: 2518: 2508: 2484: 2478: 2477: 2448: 2442: 2441: 2413: 2407: 2406: 2395: 2386: 2385: 2357: 2351: 2350: 2332: 2308: 2302: 2301: 2291: 2282:(28): 20687–90. 2267: 2261: 2260: 2250: 2240: 2216: 2207: 2206: 2196: 2186: 2154: 2145: 2144: 2134: 2110: 2101: 2100: 2064: 2058: 2057: 2029: 2023: 2022: 2011: 2005: 2004: 1993: 1987: 1977: 1966: 1956: 1807:is dependent on 1547: 1426: 1249: 1248: 1220: 1213: 1196: 1176: 1167: 1107: 1103:RefSeq (protein) 1093: 1073: 1064: 1004: 980: 961: 935: 916: 890: 871: 840: 580: 566: 557: 550: 535: 511:stria vascularis 475: 473:Top expressed in 468: 413: 411:Top expressed in 406: 385: 368: 358: 345: 334: 319: 312: 306: 295: 283: 267: 257: 244: 233: 218: 211: 205: 194: 180: 164: 158: 156:MITF - orthologs 109: 102: 79: 66: 60: 39: 38: 33: 21: 10373: 10372: 10368: 10367: 10366: 10364: 10363: 10362: 10353:Gene expression 10333: 10332: 10331: 10326: 10306: 10176: 10136: 10105: 10066: 10045: 9995: 9972: 9954: 9704: 9678: 9630: 9533: 9480: 9396: 9374: 9334: 9151: 9111: 8807: 8620: 8269: 8260: 8001: 8000: 7995: 7990: 7689: 7688: 7683: 7672: 7671: 7664: 7643: 7616: 7598: 7511: 7499: 7490: 6705: 6701: 6692: 6621: 6618:(2.2) Other Cys 6608: 6588: 6583: 6568: 6563: 6543: 6538: 6506: 6501: 6436:Steroid hormone 6425: 6420: 6321: 6316: 6180:Thyroid hormone 6169: 6160: 6141: 6116: 6071: 6016: 5914: 5820: 5807: 5805: 5800: 5728: 5723: 5661: 5656: 5527: 5525: 5520: 5475: 5470: 5284: 5265: 4939: 4926: 4917: 4875: 4870: 4834: 4833: 4824: 4780: 4779: 4772: 4749:(48): 34272–6. 4736: 4735: 4731: 4700: 4699: 4695: 4641: 4640: 4636: 4613:(19): 3852–66. 4600: 4599: 4595: 4556:(5939): 473–7. 4543: 4542: 4538: 4494: 4493: 4489: 4435: 4434: 4430: 4394: 4393: 4389: 4366:(10): 8566–71. 4353: 4352: 4348: 4294: 4293: 4289: 4235: 4234: 4230: 4194: 4193: 4184: 4140: 4139: 4135: 4089: 4088: 4084: 4053:(10): 2673–81. 4040: 4039: 4035: 4004:(10): 2111–21. 3991: 3990: 3986: 3948: 3947: 3943: 3912:(18): 5777–84. 3899: 3898: 3894: 3871:10.1038/ng.2406 3859:Nature Genetics 3856: 3855: 3851: 3813: 3812: 3808: 3771:(7130): 851–7. 3762: 3761: 3757: 3713: 3712: 3708: 3672: 3671: 3667: 3631: 3630: 3626: 3603:(50): 38663–7. 3590: 3589: 3585: 3541: 3540: 3536: 3515:(24): 5379–89. 3506: 3505: 3501: 3472:Cancer Research 3465: 3464: 3460: 3437:(29): 21920–7. 3424: 3423: 3419: 3383: 3382: 3378: 3342: 3341: 3337: 3293: 3292: 3285: 3255: 3254: 3250: 3206: 3205: 3201: 3157: 3156: 3152: 3108: 3107: 3103: 3072:(11): 2703–14. 3059: 3058: 3051: 3028:(3): 1891–904. 3015: 3014: 3007: 2971: 2970: 2966: 2937:Cancer Research 2930: 2929: 2925: 2889: 2888: 2884: 2840: 2839: 2835: 2791: 2790: 2745: 2701: 2700: 2696: 2650: 2649: 2645: 2636: 2632: 2588: 2587: 2583: 2537: 2536: 2532: 2486: 2485: 2481: 2450: 2449: 2445: 2424:(17): 3757–67. 2415: 2414: 2410: 2397: 2396: 2389: 2359: 2358: 2354: 2310: 2309: 2305: 2269: 2268: 2264: 2218: 2217: 2210: 2169:(9): e0238546. 2156: 2155: 2148: 2125:(22): 2770–80. 2112: 2111: 2104: 2081:10.1038/nrc1947 2066: 2065: 2061: 2031: 2030: 2026: 2013: 2012: 2008: 1995: 1994: 1990: 1978: 1969: 1957: 1948: 1944: 1927: 1880: 1822: 1758: 1756:Phosphorylation 1695:tRNA synthetase 1677: 1668: 1665: 1420: 1408: 1380: 1375: 1337:DNA replication 1258:View/Edit Mouse 1253:View/Edit Human 1216: 1209: 1206:Location (UCSC) 1192: 1188: 1184: 1163: 1159: 1155: 1151: 1147: 1143: 1139: 1135: 1129: 1125: 1121: 1117: 1113: 1089: 1085: 1081: 1060: 1056: 1052: 1048: 1044: 1040: 1036: 1032: 1026: 1022: 1018: 1014: 1010: 925:ENSG00000187098 818: 804:bone remodeling 677: 651: 612:protein binding 562: 531: 522: 517: 515:right ventricle 513: 509: 505: 501: 497: 493: 489: 485: 471: 460: 455: 451: 447: 443: 439: 435: 431: 429:right ventricle 427: 423: 409: 353: 340: 332: 322: 321: 320: 313: 293: 270:Gene location ( 252: 239: 231: 221: 220: 219: 212: 190: 167:Gene location ( 118: 105: 98: 75: 53: 17: 12: 11: 5: 10371: 10369: 10361: 10360: 10358:Human proteins 10355: 10350: 10345: 10335: 10334: 10328: 10327: 10319: 10316: 10315: 10312: 10311: 10308: 10307: 10305: 10304: 10295: 10294: 10293: 10288: 10283: 10273: 10268: 10267: 10266: 10261: 10256: 10246: 10245: 10244: 10239: 10229: 10224: 10223: 10222: 10217: 10212: 10207: 10202: 10197: 10186: 10184: 10178: 10177: 10175: 10174: 10169: 10164: 10158: 10156: 10138: 10137: 10135: 10134: 10129: 10124: 10118: 10116: 10107: 10106: 10104: 10103: 10098: 10097: 10096: 10091: 10080: 10078: 10068: 10067: 10062: 10055: 10054: 10051: 10050: 10047: 10046: 10044: 10043: 10042: 10041: 10036: 10031: 10026: 10021: 10016: 10005: 10003: 9997: 9996: 9994: 9993: 9988: 9982: 9980: 9974: 9973: 9971: 9970: 9964: 9962: 9956: 9955: 9953: 9952: 9951: 9950: 9945: 9940: 9935: 9925: 9924: 9923: 9918: 9917: 9916: 9911: 9906: 9891: 9886: 9881: 9880: 9879: 9874: 9869: 9864: 9859: 9854: 9849: 9844: 9839: 9834: 9829: 9824: 9819: 9814: 9809: 9804: 9794: 9793: 9792: 9787: 9777: 9776: 9775: 9770: 9765: 9760: 9750: 9749: 9748: 9743: 9738: 9733: 9723: 9717: 9715: 9706: 9705: 9703: 9702: 9697: 9691: 9689: 9680: 9679: 9677: 9676: 9671: 9670: 9669: 9664: 9659: 9654: 9643: 9641: 9632: 9631: 9629: 9628: 9623: 9622: 9621: 9616: 9611: 9606: 9601: 9596: 9591: 9586: 9581: 9576: 9566: 9565: 9564: 9559: 9554: 9543: 9541: 9539:(4.3) p53-like 9535: 9534: 9532: 9531: 9530: 9529: 9524: 9519: 9514: 9509: 9504: 9493: 9491: 9482: 9481: 9479: 9478: 9477: 9476: 9471: 9466: 9461: 9456: 9446: 9445: 9444: 9439: 9434: 9429: 9424: 9413: 9411: 9398: 9397: 9391: 9384: 9383: 9380: 9379: 9376: 9375: 9373: 9372: 9371: 9370: 9365: 9360: 9355: 9344: 9342: 9336: 9335: 9333: 9332: 9327: 9322: 9321: 9320: 9315: 9310: 9305: 9300: 9295: 9290: 9285: 9275: 9270: 9269: 9268: 9263: 9258: 9253: 9243: 9242: 9241: 9236: 9231: 9226: 9216: 9211: 9210: 9209: 9204: 9199: 9189: 9184: 9183: 9182: 9177: 9172: 9161: 9159: 9153: 9152: 9150: 9149: 9148: 9147: 9142: 9137: 9124: 9122: 9113: 9112: 9110: 9109: 9108: 9107: 9102: 9097: 9092: 9087: 9082: 9077: 9072: 9067: 9062: 9057: 9052: 9047: 9042: 9037: 9032: 9027: 9022: 9017: 9012: 9007: 9002: 8997: 8992: 8987: 8982: 8977: 8972: 8967: 8962: 8957: 8952: 8947: 8942: 8937: 8932: 8927: 8922: 8917: 8912: 8907: 8902: 8897: 8892: 8887: 8882: 8877: 8872: 8867: 8857: 8856: 8855: 8850: 8845: 8840: 8835: 8824: 8822: 8809: 8808: 8806: 8805: 8804: 8803: 8802: 8801: 8796: 8791: 8781: 8780: 8779: 8774: 8764: 8759: 8749: 8744: 8739: 8734: 8729: 8724: 8723: 8722: 8717: 8707: 8702: 8701: 8700: 8695: 8687: 8686: 8685: 8680: 8675: 8670: 8665: 8660: 8655: 8650: 8645: 8634: 8632: 8626: 8625: 8622: 8621: 8619: 8618: 8617: 8616: 8611: 8601: 8596: 8595: 8594: 8589: 8584: 8579: 8574: 8569: 8560: 8555: 8550: 8541: 8531: 8530: 8529: 8524: 8519: 8514: 8509: 8504: 8499: 8494: 8489: 8479: 8478: 8477: 8476: 8475: 8470: 8465: 8460: 8455: 8445: 8444: 8443: 8438: 8428: 8427: 8426: 8421: 8416: 8406: 8405: 8404: 8399: 8389: 8388: 8387: 8382: 8377: 8372: 8367: 8362: 8357: 8344: 8339: 8338: 8337: 8332: 8322: 8317: 8312: 8311: 8310: 8305: 8300: 8290: 8285: 8280: 8274: 8272: 8266: 8265: 8262: 8261: 8259: 8258: 8253: 8248: 8243: 8238: 8233: 8228: 8227: 8226: 8221: 8216: 8211: 8206: 8201: 8196: 8191: 8186: 8181: 8176: 8166: 8161: 8160: 8159: 8154: 8144: 8139: 8134: 8129: 8124: 8123: 8122: 8117: 8107: 8106: 8105: 8100: 8088: 8087: 8086: 8081: 8076: 8071: 8066: 8061: 8051: 8050: 8049: 8044: 8034: 8029: 8024: 8019: 8014: 8008: 8006: 7992: 7991: 7989: 7988: 7983: 7978: 7973: 7972: 7971: 7966: 7961: 7956: 7951: 7946: 7941: 7936: 7931: 7926: 7921: 7916: 7911: 7906: 7901: 7896: 7891: 7886: 7881: 7876: 7871: 7866: 7861: 7856: 7851: 7846: 7841: 7836: 7831: 7826: 7821: 7816: 7811: 7806: 7801: 7796: 7791: 7786: 7776: 7771: 7766: 7761: 7757:extended Hox: 7755: 7754: 7753: 7752: 7751: 7746: 7741: 7731: 7730: 7729: 7719: 7718: 7717: 7712: 7696: 7694: 7677: 7658: 7645: 7644: 7633: 7626: 7625: 7622: 7621: 7618: 7617: 7615: 7614: 7608: 7606: 7600: 7599: 7597: 7596: 7591: 7590: 7589: 7584: 7579: 7574: 7569: 7559: 7558: 7557: 7552: 7547: 7537: 7532: 7527: 7521: 7519: 7513: 7512: 7510: 7509: 7503: 7501: 7497: 7492: 7491: 7489: 7488: 7487: 7486: 7481: 7476: 7471: 7466: 7461: 7456: 7451: 7446: 7441: 7436: 7431: 7426: 7421: 7416: 7411: 7406: 7401: 7396: 7391: 7386: 7381: 7376: 7371: 7366: 7361: 7356: 7351: 7346: 7341: 7336: 7331: 7326: 7321: 7316: 7311: 7306: 7301: 7296: 7291: 7286: 7281: 7276: 7271: 7266: 7261: 7251: 7250: 7249: 7244: 7239: 7234: 7229: 7224: 7219: 7214: 7204: 7203: 7202: 7197: 7187: 7182: 7177: 7176: 7175: 7170: 7165: 7160: 7150: 7145: 7140: 7135: 7130: 7129: 7128: 7127: 7126: 7121: 7116: 7111: 7106: 7096: 7095: 7094: 7089: 7084: 7079: 7074: 7069: 7064: 7059: 7054: 7049: 7044: 7039: 7034: 7029: 7024: 7019: 7004: 7003: 7002: 6997: 6987: 6986: 6985: 6980: 6975: 6965: 6964: 6963: 6958: 6953: 6943: 6942: 6941: 6936: 6926: 6925: 6924: 6919: 6914: 6909: 6904: 6899: 6894: 6884: 6879: 6874: 6873: 6872: 6867: 6862: 6857: 6847: 6842: 6837: 6836: 6835: 6830: 6825: 6813: 6807: 6806: 6805: 6804: 6803: 6802: 6797: 6792: 6787: 6782: 6777: 6772: 6767: 6757: 6752: 6747: 6746: 6745: 6740: 6730: 6725: 6720: 6709: 6707: 6703: 6699: 6694: 6693: 6691: 6690: 6685: 6684: 6683: 6678: 6673: 6663: 6662: 6661: 6656: 6651: 6646: 6641: 6636: 6625: 6623: 6619: 6614: 6613: 6610: 6609: 6607: 6606: 6601: 6595: 6593: 6585: 6584: 6582: 6581: 6575: 6573: 6565: 6564: 6562: 6561: 6556: 6550: 6548: 6540: 6539: 6537: 6536: 6535: 6534: 6529: 6524: 6513: 6511: 6503: 6502: 6500: 6499: 6498: 6497: 6492: 6487: 6477: 6476: 6475: 6470: 6465: 6463:Glucocorticoid 6460: 6459: 6458: 6453: 6443: 6432: 6430: 6422: 6421: 6419: 6418: 6413: 6412: 6411: 6406: 6396: 6395: 6394: 6389: 6384: 6374: 6369: 6368: 6367: 6362: 6352: 6347: 6346: 6345: 6340: 6328: 6326: 6318: 6317: 6315: 6314: 6309: 6308: 6307: 6302: 6292: 6291: 6290: 6285: 6280: 6270: 6269: 6268: 6263: 6258: 6248: 6243: 6242: 6241: 6236: 6231: 6221: 6220: 6219: 6214: 6204: 6199: 6194: 6193: 6192: 6187: 6176: 6174: 6163: 6158: 6143: 6142: 6133: 6126: 6125: 6122: 6121: 6118: 6117: 6115: 6114: 6113: 6112: 6107: 6102: 6097: 6092: 6081: 6079: 6073: 6072: 6070: 6069: 6068: 6067: 6062: 6057: 6052: 6047: 6042: 6037: 6026: 6024: 6018: 6017: 6015: 6014: 6013: 6012: 6006: 6005: 6004: 5999: 5989: 5988: 5987: 5982: 5977: 5972: 5967: 5952: 5951: 5950: 5945: 5940: 5935: 5924: 5922: 5916: 5915: 5913: 5912: 5907: 5906: 5905: 5900: 5890: 5885: 5880: 5875: 5870: 5865: 5860: 5859: 5858: 5853: 5843: 5837: 5835: 5826: 5825: 5822: 5821: 5819: 5818: 5812: 5810: 5802: 5801: 5799: 5798: 5797: 5796: 5791: 5786: 5776: 5775: 5774: 5769: 5764: 5759: 5754: 5749: 5744: 5733: 5731: 5725: 5724: 5722: 5721: 5720: 5719: 5714: 5709: 5704: 5694: 5689: 5688: 5687: 5682: 5677: 5666: 5664: 5658: 5657: 5655: 5654: 5653: 5652: 5647: 5637: 5636: 5635: 5630: 5625: 5620: 5610: 5609: 5608: 5603: 5598: 5590: 5589: 5588: 5583: 5578: 5568: 5563: 5562: 5561: 5556: 5546: 5541: 5535: 5533: 5522: 5521: 5519: 5518: 5513: 5508: 5507: 5506: 5501: 5496: 5486: 5480: 5478: 5472: 5471: 5469: 5468: 5463: 5462: 5461: 5460: 5459: 5454: 5444: 5434: 5433: 5432: 5427: 5417: 5416: 5415: 5410: 5400: 5399: 5398: 5393: 5388: 5378: 5377: 5376: 5371: 5361: 5360: 5359: 5354: 5349: 5344: 5334: 5329: 5328: 5327: 5322: 5312: 5307: 5306: 5305: 5300: 5289: 5287: 5278: 5267: 5266: 5264: 5263: 5258: 5257: 5256: 5251: 5246: 5236: 5231: 5226: 5225: 5224: 5219: 5214: 5209: 5199: 5198: 5197: 5192: 5187: 5182: 5172: 5167: 5162: 5157: 5152: 5147: 5142: 5141: 5140: 5135: 5130: 5120: 5119: 5118: 5113: 5108: 5103: 5098: 5093: 5083: 5078: 5073: 5072: 5071: 5066: 5056: 5055: 5054: 5049: 5044: 5039: 5034: 5029: 5024: 5019: 5009: 5008: 5007: 5002: 4997: 4992: 4987: 4982: 4977: 4972: 4961: 4959: 4952:leucine zipper 4941: 4940: 4935: 4928: 4927: 4918: 4916: 4915: 4908: 4901: 4893: 4887: 4886: 4874: 4873:External links 4871: 4869: 4868: 4822: 4770: 4729: 4693: 4634: 4593: 4536: 4487: 4448:(7): 4477–82. 4428: 4387: 4346: 4287: 4228: 4182: 4133: 4082: 4033: 3984: 3957:(8): 1770–82. 3941: 3892: 3865:(10): 1080–3. 3849: 3806: 3755: 3706: 3665: 3638:Molecular Cell 3624: 3583: 3534: 3499: 3458: 3417: 3376: 3335: 3283: 3264:(18): 2171–9. 3248: 3219:(15): 6550–9. 3199: 3150: 3121:(4): 1155–68. 3101: 3049: 3005: 2964: 2943:(9): 3124–32. 2923: 2902:(3): 1838–50. 2882: 2833: 2743: 2694: 2643: 2630: 2581: 2530: 2479: 2443: 2408: 2387: 2352: 2303: 2262: 2231:(2): 934–948. 2208: 2146: 2102: 2075:(8): 593–602. 2059: 2024: 2006: 1988: 1967: 1945: 1943: 1940: 1939: 1938: 1936:Splashed white 1933: 1931:Microphthalmia 1926: 1923: 1879: 1876: 1821: 1818: 1762:phosphorylated 1757: 1754: 1750:cardiomyocytes 1684:(MAPK) pathway 1675: 1667: 1663: 1660: 1657: 1656: 1651: 1646: 1641: 1635: 1634: 1629: 1624: 1619: 1613: 1612: 1607: 1602: 1597: 1591: 1590: 1585: 1580: 1575: 1569: 1568: 1563: 1558: 1553: 1536: 1535: 1530: 1525: 1520: 1514: 1513: 1508: 1503: 1498: 1492: 1491: 1486: 1481: 1476: 1470: 1469: 1464: 1459: 1454: 1448: 1447: 1442: 1437: 1432: 1419: 1416: 1407: 1404: 1392:Tietz syndrome 1379: 1376: 1374: 1371: 1353:Tietz syndrome 1299:leucine zipper 1272:also known as 1265: 1264: 1261: 1260: 1255: 1245: 1244: 1238: 1237: 1234: 1233: 1231: 1229: 1222: 1221: 1214: 1207: 1203: 1202: 1199: 1198: 1180: 1179: 1173: 1170: 1169: 1131: 1130: 1104: 1100: 1099: 1096: 1095: 1077: 1076: 1070: 1067: 1066: 1028: 1027: 1001: 997: 996: 993: 992: 984: 983: 977: 974: 973: 965: 964: 958: 952: 951: 948: 947: 939: 938: 932: 929: 928: 920: 919: 913: 907: 906: 903: 902: 894: 893: 887: 884: 883: 875: 874: 868: 862: 861: 856: 851: 847: 846: 836: 835: 832: 831: 820: 819: 817: 816: 811: 806: 801: 796: 791: 786: 781: 776: 771: 766: 761: 756: 751: 746: 741: 736: 731: 726: 721: 716: 711: 706: 701: 696: 691: 685: 683: 679: 678: 676: 675: 670: 665: 659: 657: 653: 652: 650: 649: 644: 639: 634: 629: 624: 619: 614: 609: 604: 599: 593: 591: 587: 586: 576: 575: 572: 571: 568: 567: 559: 558: 547: 541: 540: 537: 536: 528: 527: 524: 523: 521: 520: 516: 512: 508: 504: 500: 496: 492: 488: 484: 480: 477: 476: 465: 462: 461: 459: 458: 454: 453:deltoid muscle 450: 446: 442: 438: 434: 430: 426: 422: 418: 415: 414: 402: 401: 393: 382: 376: 375: 372:RNA expression 364: 363: 360: 359: 351: 347: 346: 338: 335: 330: 324: 323: 314: 307: 301: 297: 296: 291: 285: 284: 276: 275: 263: 262: 259: 258: 250: 246: 245: 237: 234: 229: 223: 222: 213: 206: 200: 196: 195: 188: 182: 181: 173: 172: 160: 159: 116: 112: 111: 103: 95: 94: 90: 89: 86: 85: 82: 81: 71: 70: 62: 61: 50: 44: 43: 35: 34: 26: 25: 15: 13: 10: 9: 6: 4: 3: 2: 10370: 10359: 10356: 10354: 10351: 10349: 10346: 10344: 10341: 10340: 10338: 10325: 10324: 10317: 10303: 10299: 10296: 10292: 10289: 10287: 10284: 10282: 10279: 10278: 10277: 10274: 10272: 10269: 10265: 10262: 10260: 10257: 10255: 10252: 10251: 10250: 10247: 10243: 10240: 10238: 10235: 10234: 10233: 10230: 10228: 10225: 10221: 10218: 10216: 10213: 10211: 10208: 10206: 10203: 10201: 10198: 10196: 10193: 10192: 10191: 10188: 10187: 10185: 10183: 10179: 10173: 10170: 10168: 10165: 10163: 10160: 10159: 10157: 10155: 10152: 10149: 10146: 10143: 10139: 10133: 10130: 10128: 10125: 10123: 10120: 10119: 10117: 10115: 10114:Pocket domain 10112: 10108: 10102: 10099: 10095: 10092: 10090: 10087: 10086: 10085: 10082: 10081: 10079: 10077: 10076:(0.2) HMGI(Y) 10073: 10069: 10065: 10060: 10056: 10040: 10037: 10035: 10032: 10030: 10027: 10025: 10022: 10020: 10017: 10015: 10012: 10011: 10010: 10007: 10006: 10004: 10002: 9998: 9992: 9989: 9987: 9984: 9983: 9981: 9979: 9975: 9969: 9966: 9965: 9963: 9961: 9957: 9949: 9946: 9944: 9941: 9939: 9936: 9934: 9931: 9930: 9929: 9926: 9922: 9919: 9915: 9912: 9910: 9907: 9905: 9902: 9901: 9900: 9897: 9896: 9895: 9892: 9890: 9887: 9885: 9882: 9878: 9875: 9873: 9870: 9868: 9865: 9863: 9860: 9858: 9855: 9853: 9850: 9848: 9845: 9843: 9840: 9838: 9835: 9833: 9830: 9828: 9825: 9823: 9820: 9818: 9815: 9813: 9810: 9808: 9805: 9803: 9800: 9799: 9798: 9795: 9791: 9788: 9786: 9783: 9782: 9781: 9778: 9774: 9771: 9769: 9766: 9764: 9761: 9759: 9756: 9755: 9754: 9751: 9747: 9744: 9742: 9739: 9737: 9734: 9732: 9729: 9728: 9727: 9724: 9722: 9719: 9718: 9716: 9714: 9711: 9707: 9701: 9698: 9696: 9693: 9692: 9690: 9688: 9685: 9681: 9675: 9672: 9668: 9665: 9663: 9660: 9658: 9655: 9653: 9650: 9649: 9648: 9645: 9644: 9642: 9640: 9637: 9633: 9627: 9624: 9620: 9617: 9615: 9612: 9610: 9607: 9605: 9602: 9600: 9597: 9595: 9592: 9590: 9587: 9585: 9582: 9580: 9577: 9575: 9572: 9571: 9570: 9567: 9563: 9560: 9558: 9555: 9553: 9550: 9549: 9548: 9545: 9544: 9542: 9540: 9536: 9528: 9525: 9523: 9520: 9518: 9515: 9513: 9510: 9508: 9505: 9503: 9500: 9499: 9498: 9495: 9494: 9492: 9490: 9487: 9483: 9475: 9472: 9470: 9467: 9465: 9462: 9460: 9457: 9455: 9452: 9451: 9450: 9447: 9443: 9440: 9438: 9435: 9433: 9430: 9428: 9425: 9423: 9420: 9419: 9418: 9415: 9414: 9412: 9410: 9407: 9403: 9399: 9395: 9389: 9385: 9369: 9366: 9364: 9361: 9359: 9356: 9354: 9351: 9350: 9349: 9346: 9345: 9343: 9341: 9337: 9331: 9328: 9326: 9323: 9319: 9316: 9314: 9311: 9309: 9306: 9304: 9301: 9299: 9296: 9294: 9291: 9289: 9286: 9284: 9281: 9280: 9279: 9276: 9274: 9271: 9267: 9264: 9262: 9259: 9257: 9254: 9252: 9249: 9248: 9247: 9244: 9240: 9237: 9235: 9232: 9230: 9227: 9225: 9222: 9221: 9220: 9217: 9215: 9212: 9208: 9205: 9203: 9200: 9198: 9195: 9194: 9193: 9190: 9188: 9185: 9181: 9178: 9176: 9173: 9171: 9168: 9167: 9166: 9163: 9162: 9160: 9158: 9154: 9146: 9143: 9141: 9138: 9136: 9133: 9132: 9131: 9130: 9126: 9125: 9123: 9121: 9118: 9114: 9106: 9103: 9101: 9098: 9096: 9093: 9091: 9088: 9086: 9083: 9081: 9078: 9076: 9073: 9071: 9068: 9066: 9063: 9061: 9058: 9056: 9053: 9051: 9048: 9046: 9043: 9041: 9038: 9036: 9033: 9031: 9028: 9026: 9023: 9021: 9018: 9016: 9013: 9011: 9008: 9006: 9003: 9001: 8998: 8996: 8993: 8991: 8988: 8986: 8983: 8981: 8978: 8976: 8973: 8971: 8968: 8966: 8963: 8961: 8958: 8956: 8953: 8951: 8948: 8946: 8943: 8941: 8938: 8936: 8933: 8931: 8928: 8926: 8923: 8921: 8918: 8916: 8913: 8911: 8908: 8906: 8903: 8901: 8898: 8896: 8893: 8891: 8888: 8886: 8883: 8881: 8878: 8876: 8873: 8871: 8868: 8866: 8863: 8862: 8861: 8858: 8854: 8851: 8849: 8846: 8844: 8841: 8839: 8836: 8834: 8831: 8830: 8829: 8826: 8825: 8823: 8821: 8817: 8814: 8810: 8800: 8797: 8795: 8792: 8790: 8787: 8786: 8785: 8782: 8778: 8775: 8773: 8770: 8769: 8768: 8765: 8763: 8760: 8758: 8755: 8754: 8753: 8750: 8748: 8745: 8743: 8740: 8738: 8735: 8733: 8730: 8728: 8725: 8721: 8718: 8716: 8713: 8712: 8711: 8708: 8706: 8703: 8699: 8696: 8694: 8691: 8690: 8688: 8684: 8681: 8679: 8676: 8674: 8671: 8669: 8666: 8664: 8661: 8659: 8656: 8654: 8651: 8649: 8646: 8644: 8641: 8640: 8639: 8636: 8635: 8633: 8631: 8627: 8615: 8612: 8610: 8607: 8606: 8605: 8602: 8600: 8597: 8593: 8590: 8588: 8585: 8583: 8580: 8578: 8575: 8573: 8570: 8568: 8564: 8561: 8559: 8556: 8554: 8551: 8549: 8545: 8542: 8540: 8537: 8536: 8535: 8532: 8528: 8525: 8523: 8520: 8518: 8515: 8513: 8510: 8508: 8505: 8503: 8500: 8498: 8495: 8493: 8490: 8488: 8485: 8484: 8483: 8480: 8474: 8471: 8469: 8466: 8464: 8461: 8459: 8456: 8454: 8451: 8450: 8449: 8446: 8442: 8439: 8437: 8434: 8433: 8432: 8429: 8425: 8422: 8420: 8417: 8415: 8412: 8411: 8410: 8407: 8403: 8400: 8398: 8395: 8394: 8393: 8390: 8386: 8383: 8381: 8378: 8376: 8373: 8371: 8368: 8366: 8363: 8361: 8358: 8356: 8353: 8352: 8351: 8348: 8347: 8345: 8343: 8340: 8336: 8333: 8331: 8328: 8327: 8326: 8323: 8321: 8318: 8316: 8313: 8309: 8306: 8304: 8301: 8299: 8296: 8295: 8294: 8291: 8289: 8286: 8284: 8281: 8279: 8276: 8275: 8273: 8267: 8257: 8254: 8252: 8249: 8247: 8244: 8242: 8239: 8237: 8234: 8232: 8229: 8225: 8222: 8220: 8217: 8215: 8212: 8210: 8207: 8205: 8202: 8200: 8197: 8195: 8192: 8190: 8187: 8185: 8182: 8180: 8177: 8175: 8172: 8171: 8170: 8167: 8165: 8162: 8158: 8155: 8153: 8150: 8149: 8148: 8145: 8143: 8140: 8138: 8135: 8133: 8130: 8128: 8125: 8121: 8118: 8116: 8113: 8112: 8111: 8108: 8104: 8101: 8099: 8096: 8095: 8094: 8093: 8089: 8085: 8082: 8080: 8077: 8075: 8072: 8070: 8067: 8065: 8062: 8060: 8057: 8056: 8055: 8052: 8048: 8045: 8043: 8040: 8039: 8038: 8035: 8033: 8030: 8028: 8025: 8023: 8020: 8018: 8015: 8013: 8010: 8009: 8007: 8004: 7998: 7993: 7987: 7984: 7982: 7979: 7977: 7974: 7970: 7967: 7965: 7962: 7960: 7957: 7955: 7952: 7950: 7947: 7945: 7942: 7940: 7937: 7935: 7932: 7930: 7927: 7925: 7922: 7920: 7917: 7915: 7912: 7910: 7907: 7905: 7902: 7900: 7897: 7895: 7892: 7890: 7887: 7885: 7882: 7880: 7877: 7875: 7872: 7870: 7867: 7865: 7862: 7860: 7857: 7855: 7852: 7850: 7847: 7845: 7842: 7840: 7837: 7835: 7832: 7830: 7827: 7825: 7822: 7820: 7817: 7815: 7812: 7810: 7807: 7805: 7802: 7800: 7797: 7795: 7792: 7790: 7787: 7785: 7782: 7781: 7780: 7777: 7775: 7772: 7770: 7767: 7765: 7762: 7760: 7756: 7750: 7747: 7745: 7742: 7740: 7737: 7736: 7735: 7732: 7728: 7725: 7724: 7723: 7720: 7716: 7713: 7711: 7708: 7707: 7706: 7703: 7702: 7701: 7698: 7697: 7695: 7692: 7686: 7681: 7678: 7675: 7669: 7668: 7662: 7659: 7657: 7654: 7650: 7646: 7642: 7639: 7636: 7631: 7627: 7613: 7610: 7609: 7607: 7605: 7601: 7595: 7592: 7588: 7585: 7583: 7580: 7578: 7575: 7573: 7570: 7568: 7565: 7564: 7563: 7560: 7556: 7553: 7551: 7548: 7546: 7543: 7542: 7541: 7538: 7536: 7533: 7531: 7528: 7526: 7523: 7522: 7520: 7518: 7514: 7508: 7505: 7504: 7502: 7500: 7493: 7485: 7482: 7480: 7477: 7475: 7472: 7470: 7467: 7465: 7462: 7460: 7457: 7455: 7452: 7450: 7447: 7445: 7442: 7440: 7437: 7435: 7432: 7430: 7427: 7425: 7422: 7420: 7417: 7415: 7412: 7410: 7407: 7405: 7402: 7400: 7397: 7395: 7392: 7390: 7387: 7385: 7382: 7380: 7377: 7375: 7372: 7370: 7367: 7365: 7362: 7360: 7357: 7355: 7352: 7350: 7347: 7345: 7342: 7340: 7337: 7335: 7332: 7330: 7327: 7325: 7322: 7320: 7317: 7315: 7312: 7310: 7307: 7305: 7302: 7300: 7297: 7295: 7292: 7290: 7287: 7285: 7282: 7280: 7277: 7275: 7272: 7270: 7267: 7265: 7262: 7260: 7257: 7256: 7255: 7252: 7248: 7245: 7243: 7240: 7238: 7235: 7233: 7230: 7228: 7225: 7223: 7220: 7218: 7215: 7213: 7210: 7209: 7208: 7205: 7201: 7198: 7196: 7193: 7192: 7191: 7188: 7186: 7183: 7181: 7178: 7174: 7171: 7169: 7166: 7164: 7161: 7159: 7156: 7155: 7154: 7151: 7149: 7146: 7144: 7141: 7139: 7136: 7134: 7131: 7125: 7122: 7120: 7117: 7115: 7112: 7110: 7107: 7105: 7102: 7101: 7100: 7097: 7093: 7090: 7088: 7085: 7083: 7080: 7078: 7075: 7073: 7070: 7068: 7065: 7063: 7060: 7058: 7055: 7053: 7050: 7048: 7045: 7043: 7040: 7038: 7035: 7033: 7030: 7028: 7025: 7023: 7020: 7018: 7015: 7014: 7013: 7010: 7009: 7008: 7007:Sp/KLF family 7005: 7001: 6998: 6996: 6993: 6992: 6991: 6988: 6984: 6981: 6979: 6976: 6974: 6971: 6970: 6969: 6966: 6962: 6959: 6957: 6954: 6952: 6949: 6948: 6947: 6944: 6940: 6937: 6935: 6932: 6931: 6930: 6927: 6923: 6920: 6918: 6915: 6913: 6910: 6908: 6905: 6903: 6900: 6898: 6895: 6893: 6890: 6889: 6888: 6885: 6883: 6880: 6878: 6875: 6871: 6868: 6866: 6863: 6861: 6858: 6856: 6853: 6852: 6851: 6848: 6846: 6843: 6841: 6838: 6834: 6831: 6829: 6826: 6824: 6821: 6820: 6819: 6818: 6814: 6812: 6809: 6808: 6801: 6798: 6796: 6793: 6791: 6788: 6786: 6783: 6781: 6778: 6776: 6773: 6771: 6768: 6766: 6763: 6762: 6761: 6758: 6756: 6753: 6751: 6748: 6744: 6741: 6739: 6736: 6735: 6734: 6731: 6729: 6726: 6724: 6721: 6719: 6716: 6715: 6714: 6711: 6710: 6708: 6706: 6695: 6689: 6686: 6682: 6679: 6677: 6674: 6672: 6669: 6668: 6667: 6664: 6660: 6657: 6655: 6652: 6650: 6647: 6645: 6642: 6640: 6637: 6635: 6632: 6631: 6630: 6627: 6626: 6624: 6622: 6615: 6605: 6602: 6600: 6597: 6596: 6594: 6591: 6586: 6580: 6577: 6576: 6574: 6571: 6566: 6560: 6557: 6555: 6552: 6551: 6549: 6546: 6541: 6533: 6530: 6528: 6525: 6523: 6520: 6519: 6518: 6515: 6514: 6512: 6509: 6504: 6496: 6493: 6491: 6488: 6486: 6483: 6482: 6481: 6478: 6474: 6471: 6469: 6466: 6464: 6461: 6457: 6454: 6452: 6449: 6448: 6447: 6444: 6442: 6439: 6438: 6437: 6434: 6433: 6431: 6428: 6423: 6417: 6414: 6410: 6407: 6405: 6402: 6401: 6400: 6397: 6393: 6390: 6388: 6385: 6383: 6380: 6379: 6378: 6375: 6373: 6370: 6366: 6363: 6361: 6358: 6357: 6356: 6353: 6351: 6348: 6344: 6341: 6339: 6335: 6334: 6333: 6330: 6329: 6327: 6324: 6319: 6313: 6310: 6306: 6303: 6301: 6298: 6297: 6296: 6293: 6289: 6286: 6284: 6281: 6279: 6276: 6275: 6274: 6271: 6267: 6264: 6262: 6259: 6257: 6254: 6253: 6252: 6249: 6247: 6244: 6240: 6237: 6235: 6232: 6230: 6227: 6226: 6225: 6222: 6218: 6215: 6213: 6210: 6209: 6208: 6205: 6203: 6200: 6198: 6195: 6191: 6188: 6186: 6183: 6182: 6181: 6178: 6177: 6175: 6172: 6167: 6164: 6162: 6155: 6152: 6148: 6144: 6139: 6136: 6131: 6127: 6111: 6108: 6106: 6103: 6101: 6098: 6096: 6093: 6091: 6088: 6087: 6086: 6083: 6082: 6080: 6078: 6074: 6066: 6063: 6061: 6058: 6056: 6053: 6051: 6048: 6046: 6043: 6041: 6038: 6036: 6033: 6032: 6031: 6028: 6027: 6025: 6023: 6019: 6010: 6007: 6003: 6000: 5998: 5995: 5994: 5993: 5990: 5986: 5983: 5981: 5978: 5976: 5973: 5971: 5968: 5966: 5963: 5962: 5961: 5958: 5957: 5956: 5953: 5949: 5946: 5944: 5941: 5939: 5936: 5934: 5931: 5930: 5929: 5926: 5925: 5923: 5921: 5917: 5911: 5908: 5904: 5901: 5899: 5896: 5895: 5894: 5891: 5889: 5886: 5884: 5881: 5879: 5876: 5874: 5871: 5869: 5866: 5864: 5861: 5857: 5854: 5852: 5849: 5848: 5847: 5844: 5842: 5839: 5838: 5836: 5834: 5831: 5827: 5817: 5814: 5813: 5811: 5803: 5795: 5792: 5790: 5787: 5785: 5782: 5781: 5780: 5777: 5773: 5770: 5768: 5765: 5763: 5760: 5758: 5755: 5753: 5750: 5748: 5745: 5743: 5740: 5739: 5738: 5735: 5734: 5732: 5726: 5718: 5715: 5713: 5710: 5708: 5705: 5703: 5700: 5699: 5698: 5695: 5693: 5690: 5686: 5683: 5681: 5678: 5676: 5673: 5672: 5671: 5668: 5667: 5665: 5659: 5651: 5648: 5646: 5643: 5642: 5641: 5638: 5634: 5631: 5629: 5626: 5624: 5621: 5619: 5616: 5615: 5614: 5611: 5607: 5604: 5602: 5599: 5597: 5594: 5593: 5591: 5587: 5584: 5582: 5579: 5577: 5574: 5573: 5572: 5569: 5567: 5564: 5560: 5557: 5555: 5552: 5551: 5550: 5547: 5545: 5542: 5540: 5537: 5536: 5534: 5531: 5523: 5517: 5514: 5512: 5509: 5505: 5502: 5500: 5497: 5495: 5492: 5491: 5490: 5487: 5485: 5482: 5481: 5479: 5473: 5467: 5464: 5458: 5455: 5453: 5450: 5449: 5448: 5445: 5443: 5440: 5439: 5438: 5435: 5431: 5428: 5426: 5423: 5422: 5421: 5418: 5414: 5411: 5409: 5406: 5405: 5404: 5401: 5397: 5394: 5392: 5389: 5387: 5384: 5383: 5382: 5379: 5375: 5372: 5370: 5367: 5366: 5365: 5362: 5358: 5355: 5353: 5350: 5348: 5345: 5343: 5340: 5339: 5338: 5335: 5333: 5330: 5326: 5323: 5321: 5318: 5317: 5316: 5313: 5311: 5308: 5304: 5301: 5299: 5296: 5295: 5294: 5291: 5290: 5288: 5282: 5279: 5276: 5272: 5268: 5262: 5259: 5255: 5252: 5250: 5247: 5245: 5242: 5241: 5240: 5237: 5235: 5232: 5230: 5227: 5223: 5220: 5218: 5215: 5213: 5210: 5208: 5205: 5204: 5203: 5200: 5196: 5193: 5191: 5188: 5186: 5183: 5181: 5178: 5177: 5176: 5173: 5171: 5168: 5166: 5163: 5161: 5158: 5156: 5153: 5151: 5148: 5146: 5143: 5139: 5136: 5134: 5131: 5129: 5126: 5125: 5124: 5121: 5117: 5114: 5112: 5109: 5107: 5104: 5102: 5099: 5097: 5094: 5092: 5089: 5088: 5087: 5084: 5082: 5079: 5077: 5074: 5070: 5067: 5065: 5062: 5061: 5060: 5057: 5053: 5050: 5048: 5045: 5043: 5040: 5038: 5035: 5033: 5030: 5028: 5025: 5023: 5020: 5018: 5015: 5014: 5013: 5010: 5006: 5003: 5001: 4998: 4996: 4993: 4991: 4988: 4986: 4983: 4981: 4978: 4976: 4973: 4971: 4968: 4967: 4966: 4963: 4962: 4960: 4957: 4953: 4950: 4946: 4942: 4938: 4933: 4929: 4925: 4921: 4914: 4909: 4907: 4902: 4900: 4895: 4894: 4891: 4884: 4880: 4877: 4876: 4872: 4864: 4860: 4855: 4850: 4846: 4842: 4838: 4831: 4829: 4827: 4823: 4818: 4814: 4809: 4804: 4800: 4796: 4792: 4788: 4784: 4777: 4775: 4771: 4766: 4762: 4757: 4752: 4748: 4744: 4740: 4733: 4730: 4725: 4721: 4717: 4713: 4710:(2): 135–43. 4709: 4705: 4697: 4694: 4689: 4685: 4680: 4675: 4670: 4665: 4661: 4657: 4653: 4649: 4645: 4638: 4635: 4630: 4626: 4621: 4616: 4612: 4608: 4604: 4597: 4594: 4589: 4585: 4581: 4577: 4572: 4567: 4563: 4559: 4555: 4551: 4547: 4540: 4537: 4532: 4528: 4524: 4520: 4515: 4510: 4507:(2): 304–10. 4506: 4502: 4498: 4491: 4488: 4483: 4479: 4474: 4469: 4464: 4459: 4455: 4451: 4447: 4443: 4439: 4432: 4429: 4424: 4420: 4415: 4410: 4407:(3): 1962–6. 4406: 4402: 4398: 4391: 4388: 4383: 4379: 4374: 4369: 4365: 4361: 4357: 4350: 4347: 4342: 4338: 4333: 4328: 4323: 4318: 4314: 4310: 4306: 4302: 4298: 4291: 4288: 4283: 4279: 4274: 4269: 4264: 4259: 4255: 4251: 4248:(8): e24064. 4247: 4243: 4239: 4232: 4229: 4224: 4220: 4215: 4210: 4206: 4202: 4198: 4191: 4189: 4187: 4183: 4178: 4174: 4169: 4164: 4160: 4156: 4153:(3): 301–12. 4152: 4148: 4144: 4137: 4134: 4129: 4125: 4121: 4117: 4113: 4112:10.1038/34681 4109: 4105: 4101: 4097: 4093: 4086: 4083: 4078: 4074: 4069: 4064: 4060: 4056: 4052: 4048: 4044: 4037: 4034: 4029: 4025: 4020: 4015: 4011: 4007: 4003: 3999: 3995: 3988: 3985: 3980: 3976: 3972: 3968: 3964: 3960: 3956: 3952: 3945: 3942: 3937: 3933: 3928: 3923: 3919: 3915: 3911: 3907: 3903: 3896: 3893: 3888: 3884: 3880: 3876: 3872: 3868: 3864: 3860: 3853: 3850: 3845: 3841: 3837: 3833: 3829: 3825: 3821: 3817: 3810: 3807: 3802: 3798: 3794: 3790: 3786: 3782: 3778: 3774: 3770: 3766: 3759: 3756: 3751: 3747: 3742: 3737: 3733: 3729: 3725: 3721: 3717: 3710: 3707: 3702: 3698: 3693: 3688: 3685:(2): 145–51. 3684: 3680: 3676: 3669: 3666: 3661: 3657: 3652: 3647: 3644:(5): 603–11. 3643: 3639: 3635: 3628: 3625: 3620: 3616: 3611: 3606: 3602: 3598: 3594: 3587: 3584: 3579: 3575: 3570: 3565: 3561: 3557: 3553: 3549: 3545: 3538: 3535: 3530: 3526: 3522: 3518: 3514: 3510: 3503: 3500: 3495: 3491: 3486: 3481: 3478:(2): 509–16. 3477: 3473: 3469: 3462: 3459: 3454: 3450: 3445: 3440: 3436: 3432: 3428: 3421: 3418: 3413: 3409: 3404: 3399: 3395: 3391: 3387: 3380: 3377: 3372: 3368: 3363: 3358: 3354: 3350: 3346: 3339: 3336: 3331: 3327: 3322: 3317: 3313: 3309: 3306:(1): 333–43. 3305: 3301: 3297: 3290: 3288: 3284: 3279: 3275: 3271: 3267: 3263: 3259: 3258:Life Sciences 3252: 3249: 3244: 3240: 3235: 3230: 3226: 3222: 3218: 3214: 3210: 3203: 3200: 3195: 3191: 3186: 3181: 3177: 3173: 3170:(1): 99–110. 3169: 3165: 3161: 3154: 3151: 3146: 3142: 3138: 3134: 3129: 3124: 3120: 3116: 3115:FASEB Journal 3112: 3105: 3102: 3097: 3093: 3088: 3083: 3079: 3075: 3071: 3067: 3063: 3056: 3054: 3050: 3045: 3041: 3036: 3031: 3027: 3023: 3019: 3012: 3010: 3006: 3001: 2997: 2992: 2987: 2984:(6): 565–76. 2983: 2979: 2975: 2968: 2965: 2960: 2956: 2951: 2946: 2942: 2938: 2934: 2927: 2924: 2919: 2915: 2910: 2905: 2901: 2897: 2893: 2886: 2883: 2878: 2874: 2870: 2866: 2861: 2856: 2853:(6): 707–18. 2852: 2848: 2844: 2837: 2834: 2829: 2825: 2821: 2817: 2812: 2807: 2804:(6): 665–76. 2803: 2799: 2795: 2788: 2786: 2784: 2782: 2780: 2778: 2776: 2774: 2772: 2770: 2768: 2766: 2764: 2762: 2760: 2758: 2756: 2754: 2752: 2750: 2748: 2744: 2739: 2735: 2731: 2727: 2722: 2717: 2714:(3): 451–60. 2713: 2709: 2705: 2698: 2695: 2690: 2686: 2681: 2676: 2671: 2666: 2662: 2658: 2654: 2647: 2644: 2640: 2634: 2631: 2626: 2622: 2617: 2612: 2608: 2604: 2600: 2596: 2592: 2585: 2582: 2577: 2573: 2568: 2563: 2558: 2553: 2549: 2545: 2541: 2534: 2531: 2526: 2522: 2517: 2512: 2507: 2502: 2498: 2494: 2490: 2483: 2480: 2475: 2471: 2467: 2463: 2459: 2455: 2447: 2444: 2439: 2435: 2431: 2427: 2423: 2419: 2412: 2409: 2404: 2400: 2394: 2392: 2388: 2383: 2379: 2375: 2371: 2368:(11): 442–8. 2367: 2363: 2356: 2353: 2348: 2344: 2340: 2336: 2331: 2326: 2322: 2318: 2314: 2307: 2304: 2299: 2295: 2290: 2285: 2281: 2277: 2273: 2266: 2263: 2258: 2254: 2249: 2244: 2239: 2234: 2230: 2226: 2222: 2215: 2213: 2209: 2204: 2200: 2195: 2190: 2185: 2180: 2176: 2172: 2168: 2164: 2160: 2153: 2151: 2147: 2142: 2138: 2133: 2128: 2124: 2120: 2116: 2109: 2107: 2103: 2098: 2094: 2090: 2086: 2082: 2078: 2074: 2070: 2063: 2060: 2055: 2051: 2047: 2043: 2040:(4): 689–96. 2039: 2035: 2028: 2025: 2020: 2016: 2010: 2007: 2002: 1998: 1992: 1989: 1985: 1981: 1976: 1974: 1972: 1968: 1964: 1960: 1955: 1953: 1951: 1947: 1941: 1937: 1934: 1932: 1929: 1928: 1924: 1922: 1920: 1916: 1912: 1908: 1903: 1901: 1896: 1892: 1888: 1884: 1877: 1875: 1871: 1867: 1864: 1860: 1858: 1852: 1850: 1845: 1841: 1839: 1835: 1831: 1827: 1819: 1817: 1815: 1810: 1806: 1802: 1798: 1794: 1790: 1786: 1782: 1778: 1774: 1771: 1767: 1766:MAPK/BRAF/ERK 1763: 1755: 1753: 1751: 1747: 1743: 1742:isoproterenol 1738: 1735: 1730: 1726: 1722: 1718: 1712: 1710: 1705: 1700: 1696: 1691: 1689: 1685: 1681: 1673: 1661: 1655: 1652: 1650: 1647: 1645: 1642: 1640: 1637: 1636: 1633: 1630: 1628: 1625: 1623: 1620: 1618: 1615: 1614: 1611: 1608: 1606: 1603: 1601: 1598: 1596: 1593: 1592: 1589: 1586: 1584: 1581: 1579: 1576: 1574: 1571: 1570: 1567: 1562: 1557: 1552: 1548: 1545: 1543: 1534: 1531: 1529: 1526: 1524: 1521: 1519: 1516: 1515: 1512: 1509: 1507: 1504: 1502: 1499: 1497: 1494: 1493: 1490: 1487: 1485: 1482: 1480: 1477: 1475: 1472: 1471: 1468: 1465: 1463: 1460: 1458: 1455: 1453: 1450: 1449: 1446: 1441: 1436: 1431: 1427: 1424: 1417: 1415: 1412: 1405: 1403: 1399: 1395: 1393: 1389: 1385: 1377: 1372: 1370: 1366: 1364: 1363: 1358: 1354: 1350: 1346: 1342: 1338: 1334: 1330: 1326: 1322: 1317: 1315: 1311: 1307: 1303: 1300: 1297: 1292: 1290: 1287: 1283: 1279: 1275: 1271: 1259: 1254: 1250: 1246: 1243: 1239: 1232: 1230: 1227: 1223: 1219: 1215: 1212: 1208: 1204: 1197: 1195: 1191: 1187: 1181: 1177: 1174: 1168: 1166: 1162: 1158: 1154: 1150: 1146: 1142: 1138: 1132: 1128: 1124: 1120: 1116: 1112: 1108: 1105: 1101: 1094: 1092: 1088: 1084: 1078: 1074: 1071: 1065: 1063: 1059: 1055: 1051: 1047: 1043: 1039: 1035: 1029: 1025: 1021: 1017: 1013: 1009: 1005: 1002: 1000:RefSeq (mRNA) 998: 991: 990: 985: 981: 978: 972: 971: 966: 962: 959: 957: 953: 946: 945: 940: 936: 933: 927: 926: 921: 917: 914: 912: 908: 901: 900: 895: 891: 888: 882: 881: 876: 872: 869: 867: 863: 860: 857: 855: 852: 848: 845: 841: 837: 830: 826: 821: 815: 812: 810: 807: 805: 802: 800: 797: 795: 792: 790: 787: 785: 782: 780: 777: 775: 772: 770: 767: 765: 762: 760: 757: 755: 752: 750: 747: 745: 742: 740: 737: 735: 732: 730: 727: 725: 722: 720: 717: 715: 712: 710: 707: 705: 702: 700: 697: 695: 692: 690: 687: 686: 684: 681: 680: 674: 671: 669: 666: 664: 661: 660: 658: 655: 654: 648: 645: 643: 642:E-box binding 640: 638: 635: 633: 630: 628: 625: 623: 620: 618: 615: 613: 610: 608: 605: 603: 600: 598: 595: 594: 592: 589: 588: 585: 584:Gene ontology 581: 577: 565: 560: 556: 551: 548: 546: 542: 534: 529: 518: 514: 510: 506: 502: 498: 494: 490: 486: 482: 481: 478: 474: 469: 466: 456: 452: 448: 444: 440: 436: 432: 428: 424: 420: 419: 416: 412: 407: 404: 403: 400: 398: 394: 392: 391: 387: 386: 383: 381: 377: 373: 369: 365: 357: 352: 348: 344: 339: 329: 325: 318: 311: 305: 298: 290: 286: 282: 277: 273: 268: 264: 256: 251: 247: 243: 238: 228: 224: 217: 210: 204: 197: 193: 187: 183: 179: 174: 170: 165: 161: 157: 153: 149: 145: 141: 137: 133: 129: 125: 121: 113: 108: 101: 96: 91: 80: 78: 72: 67: 64: 63: 59: 56: 49: 45: 40: 36: 32: 27: 22: 19: 10320: 10275: 10231: 10189: 10181: 10153: 10147: 10141: 10110: 10075: 10063: 10000: 9977: 9959: 9927: 9898: 9779: 9709: 9683: 9635: 9538: 9485: 9405: 9393: 9347: 9339: 9245: 9191: 9164: 9156: 9127: 9116: 8860:FOX proteins 8820:winged helix 8812: 8783: 8766: 8709: 8629: 8603: 8481: 8447: 8430: 8408: 8391: 8324: 8292: 8146: 8109: 8090: 8036: 8002: 7996: 7690: 7684: 7673: 7667:Antennapedia 7665: 7652: 7640: 7634: 7603: 7561: 7539: 7516: 7495: 7253: 7206: 7152: 7098: 7011: 6989: 6967: 6945: 6928: 6886: 6815: 6697: 6665: 6617: 6589: 6569: 6544: 6507: 6473:Progesterone 6426: 6322: 6170: 6156: 6150: 6134: 6076: 6029: 6021: 5919: 5862: 5829: 5778: 5736: 5696: 5669: 5639: 5612: 5446: 5436: 5419: 5402: 5314: 5270: 5238: 5201: 5058: 4948: 4936: 4844: 4841:Cell Reports 4840: 4793:(1): 18–33. 4790: 4786: 4746: 4742: 4732: 4707: 4703: 4696: 4651: 4647: 4637: 4610: 4606: 4596: 4553: 4549: 4539: 4504: 4500: 4490: 4445: 4441: 4431: 4404: 4400: 4390: 4363: 4359: 4349: 4304: 4300: 4290: 4245: 4241: 4231: 4204: 4200: 4150: 4146: 4136: 4095: 4091: 4085: 4050: 4046: 4036: 4001: 3997: 3987: 3954: 3950: 3944: 3909: 3905: 3895: 3862: 3858: 3852: 3819: 3815: 3809: 3768: 3764: 3758: 3723: 3719: 3709: 3682: 3678: 3668: 3641: 3637: 3627: 3600: 3596: 3586: 3551: 3547: 3537: 3512: 3508: 3502: 3475: 3471: 3461: 3434: 3430: 3420: 3396:(1): 402–6. 3393: 3389: 3379: 3352: 3348: 3338: 3303: 3299: 3261: 3257: 3251: 3216: 3212: 3202: 3167: 3163: 3153: 3118: 3114: 3104: 3069: 3065: 3025: 3021: 2981: 2977: 2967: 2940: 2936: 2926: 2899: 2895: 2885: 2850: 2846: 2836: 2801: 2797: 2711: 2707: 2697: 2660: 2656: 2646: 2633: 2601:(6): 446–8. 2598: 2594: 2584: 2550:(2): 254–5. 2547: 2543: 2533: 2496: 2492: 2482: 2457: 2453: 2446: 2421: 2417: 2411: 2402: 2365: 2361: 2355: 2323:(1): 27–40. 2320: 2316: 2306: 2279: 2275: 2265: 2228: 2224: 2166: 2162: 2122: 2118: 2072: 2068: 2062: 2037: 2033: 2027: 2018: 2009: 2000: 1991: 1904: 1881: 1872: 1868: 1861: 1853: 1846: 1842: 1823: 1820:Interactions 1759: 1739: 1725:neuropathies 1715:through the 1713: 1692: 1669: 1662:The LysRS-Ap 1539: 1421: 1418:Target genes 1409: 1400: 1396: 1381: 1367: 1360: 1332: 1318: 1293: 1285: 1277: 1273: 1269: 1268: 1190:NP_001171520 1186:NP_001106669 1183: 1165:NP_001341537 1161:NP_001341536 1157:NP_001341535 1153:NP_001341534 1149:NP_001341533 1134: 1119:NP_001171897 1115:NP_001171896 1087:NM_001178049 1083:NM_001113198 1080: 1062:NM_001354608 1058:NM_001354607 1054:NM_001354606 1050:NM_001354605 1046:NM_001354604 1031: 1016:NM_001184968 1012:NM_001184967 987: 968: 942: 923: 897: 878: 858: 853: 774:pigmentation 499:ciliary body 483:pineal gland 395: 388: 115:External IDs 74: 18: 10001:(4.11) Runt 7656:Homeodomain 7254:zinc finger 6590:subfamily 0 6570:subfamily 6 6545:subfamily 5 6508:subfamily 4 6427:subfamily 3 6323:subfamily 2 6171:subfamily 1 6138:Zinc finger 5381:Neurogenins 4949:(1.1) Basic 4654:(1): 1055. 3726:(1): 4664. 3509:Development 2978:Cancer Cell 2418:Development 2399:"MITF gene" 1746:hypertrophy 1411:Melanocytes 1362:Xiphophorus 1310:osteoclasts 1306:melanocytes 663:nucleoplasm 597:DNA binding 354:97,998,310 341:97,784,013 253:69,968,336 240:69,739,456 93:Identifiers 10337:Categories 8534:POU domain 7674:ANTP class 7604:(2.6) WRKY 6887:GLI family 6022:(1.5) RF-X 5920:(1.4) NF-1 2499:(1): 170. 2493:Mol Cancer 2460:: 117–26. 1986:, May 2017 1965:, May 2017 1942:References 1902:by eIF2α. 1787:including 1734:importin-β 1680:mast cells 1542:microarray 1314:mast cells 1294:MITF is a 437:myocardium 399:(ortholog) 136:HomoloGene 10321:see also 10162:Apetala 2 8816:Fork head 7496:(2.4) Cys 6698:(2.3) Cys 5430:Scleraxis 3887:205345993 1887:glutamine 1384:mutations 1378:Mutations 1357:zebrafish 1194:NP_032627 1145:NP_937821 1141:NP_937820 1137:NP_937802 1127:NP_937801 1123:NP_006713 1111:NP_000239 1091:NM_008601 1042:NM_198178 1038:NM_198177 1034:NM_198159 1024:NM_198158 1020:NM_006722 1008:NM_000248 844:Orthologs 144:GeneCards 9639:MADS box 7779:Homeobox 7691:Hox-like 7685:protoHOX 6446:Estrogen 6441:Androgen 6295:Rev-ErbA 5833:bHLH-ZIP 5808:bHLH-COE 5347:Myogenin 4863:31216476 4817:28096186 4765:10567402 4724:10694430 4688:30705290 4629:21752829 4588:20353685 4580:19556463 4531:22801820 4523:11818452 4482:11930005 4423:11709556 4382:11751862 4341:30150413 4282:21887372 4242:PLOS ONE 4223:28584020 4177:10673502 4128:26589863 4077:16998588 4028:21402779 3979:26481581 3971:20533549 3936:18644867 3879:22961002 3836:28394346 3816:Oncogene 3793:17314971 3750:31604935 3701:14975237 3679:Immunity 3660:19524539 3619:17062567 3578:12136092 3529:11076759 3494:14744763 3453:10770922 3412:11700328 3371:18281284 3330:12819038 3278:12204775 3243:15254223 3194:18983539 3145:14304386 3137:18039926 3096:12032083 3044:17105730 3000:15607961 2959:18451137 2918:17085443 2877:14863011 2869:12086670 2828:24698373 2820:19067971 2738:24064612 2730:10750559 2689:22554099 2625:10851256 2576:23162308 2525:33276788 2474:14597395 2438:10433906 2347:43471663 2339:19995375 2257:31777941 2203:32881934 2163:PLOS ONE 2097:20829389 2089:16862190 2054:15050900 1982:– 1961:– 1925:See also 1760:MITF is 1556:TNFRSF14 1406:Melanoma 1345:melanoma 1242:Wikidata 823:Sources: 487:gastrula 10039:RUNX1T1 10019:CBFA2T3 10014:CBFA2T2 9894:TCF/LEF 8003:NK-like 7997:metaHOX 7700:ParaHox 7641:domains 6332:COUP-TF 5806:Group F 5729:Group E 5662:Group D 5526:Group C 5476:Group B 5420:Paraxis 5285:Group A 4808:5287109 4679:6355916 4656:Bibcode 4558:Bibcode 4550:Science 4450:Bibcode 4332:6140509 4309:Bibcode 4273:3161112 4250:Bibcode 4120:9440696 4100:Bibcode 4068:1570375 4019:3133347 3927:2546939 3844:6790116 3801:4421616 3773:Bibcode 3741:6789022 3321:1868174 3185:2714741 2680:3391993 2616:1734605 2567:3491306 2516:7718690 2382:8578601 2298:8407885 2248:6954422 2194:7470386 2171:Bibcode 2141:7958932 1984:Ensembl 1963:Ensembl 1805:pathway 1785:kinases 1622:TBC1D16 1511:SLC45A2 1341:melanin 1282:protein 1278:bHLHe32 956:UniProt 911:Ensembl 850:Species 829:QuickGO 668:nucleus 491:decidua 457:urethra 374:pattern 100:Aliases 8752:Bicoid 8017:BARHL2 8012:BARHL1 7594:JMJD1B 7507:HIVEP1 5992:I-SMAD 5960:R-SMAD 5878:MLXIPL 5633:Period 5559:ARNTL2 5364:NeuroD 4885:(MeSH) 4861: 4815: 4805: 4763: 4722: 4686: 4676: 4627: 4586: 4578: 4529: 4521: 4480: 4473:123673 4470: 4421: 4380: 4339: 4329: 4280: 4270: 4221: 4175: 4168:316361 4165: 4126: 4118: 4092:Nature 4075: 4065: 4026: 4016: 3977: 3969: 3934: 3924: 3885: 3877: 3842: 3834: 3799: 3791: 3765:Nature 3748: 3738: 3699: 3658: 3617: 3576: 3569:135745 3566: 3527: 3492: 3451: 3410: 3369: 3328: 3318: 3276: 3241: 3234:444869 3231: 3192: 3182: 3143: 3135: 3094: 3087:126018 3084: 3042: 2998: 2957: 2916: 2875: 2867: 2826: 2818: 2736: 2728: 2687: 2677: 2663:: 85. 2623: 2613: 2574: 2564: 2523: 2513: 2472: 2436: 2380: 2345: 2337: 2296: 2255: 2245: 2201: 2191: 2139: 2095: 2087: 2052: 1911:5' UTR 1909:. The 1717:T-cell 1699:Serine 1693:Lysyl- 1654:SLC7A8 1639:MICAL1 1617:SLC1A4 1610:FRMD4B 1600:LGALS3 1588:INPP4B 1578:APOLD1 1566:RBM35A 1501:RAB27A 1479:GPR143 1351:, and 1312:, and 1228:search 1226:PubMed 989:Q08874 970:O75030 866:Entrez 545:BioGPS 433:glutes 132:104554 124:156845 10302:Sigma 10167:EREBP 10151:EREBP 10142:(0.5) 10111:(0.3) 10034:RUNX3 10029:RUNX2 10024:RUNX1 9968:TFCP2 9889:SSRP1 9710:(4.7) 9700:TBPL1 9684:(4.6) 9636:(4.4) 9486:(4.2) 9427:NFKB2 9422:NFKB1 9417:NF-κB 9406:(4.1) 9330:MYBL2 9117:(3.4) 8813:(3.3) 8762:BICD2 8737:SHOX2 8705:PROP1 8689:PRRX 8599:SATB2 8544:BRN-3 8539:PIT-1 8431:PKNOX 8346:TALE 8342:NOBOX 8315:HESX1 8288:CUTL1 8270:other 8164:NANOG 8027:BARX2 8022:BARX1 7774:MEOX2 7769:MEOX1 7653:(3.1) 7562:JARID 7535:GRLF1 7530:DIDO1 7190:Zbtb7 7180:TSHZ3 7148:PRDM9 6946:HIVEP 6811:ATBF1 6765:TFIIH 6750:TFIIF 6733:TFIIE 6728:TFIID 6723:TFIIB 6718:TFIIA 6688:TRPS1 6554:LRH-1 6532:NURR1 6522:NGFIB 6350:Ear-2 6151:(2.1) 5893:SREBP 5830:(1.3) 5592:NPAS 5581:EPAS1 5566:CLOCK 5554:ARNTL 5528:bHLH- 5504:n-Myc 5499:l-Myc 5494:c-Myc 5484:FIGLA 5466:Twist 5425:TCF15 5332:MESP2 5310:ATOH1 5303:ASCL2 5298:ASCL1 5229:NFIL3 5160:GABPA 5155:DDIT3 5086:C/EBP 5081:BLZF1 5042:c-Jun 5032:FOSL2 5027:FOSL1 5017:c-Fos 4584:S2CID 4527:S2CID 4124:S2CID 3975:S2CID 3883:S2CID 3840:S2CID 3797:S2CID 3141:S2CID 2873:S2CID 2824:S2CID 2734:S2CID 2343:S2CID 2093:S2CID 1907:DDX3X 1900:eIF2B 1895:eIF2α 1849:STAT3 1830:PIAS3 1814:D816V 1777:GSK-3 1729:Nudix 1688:FcεRI 1672:LysRS 1649:ITPKB 1632:ASAH1 1605:GREB1 1595:CAPN3 1583:KCNN2 1573:PLA1A 1533:TYRP1 1523:TRPM1 1496:OSTM1 1489:MLANA 1474:GPNMB 1467:EDNRB 1457:CLCN7 1445:BIRC7 1440:BEST1 1280:is a 899:17342 859:Mouse 854:Human 825:Amigo 397:Mouse 390:Human 337:Start 272:Mouse 236:Start 169:Human 10271:MNDA 10190:ARID 10145:AP-2 10132:RBL2 10127:RBL1 10101:HBP1 10084:HMGA 9991:YBX1 9986:CSDA 9921:LEF1 9753:HMGN 9726:HMGB 9647:Mef2 9626:MYRF 9614:TBR2 9609:TBR1 9557:TP63 9497:STAT 9489:STAT 9449:NFAT 9442:RELB 9437:RELA 9392:(4) 9273:FLI1 9239:SPIB 8940:D4L6 8935:D4L5 8930:D4L4 8925:D4L3 8920:D4L1 8784:PITX 8747:VSX2 8742:VSX1 8732:SHOX 8710:PHOX 8392:MEIS 8320:HOPX 8256:VAX2 8251:VAX1 8246:TLX3 8241:TLX2 8236:TLX1 8231:NATO 8214:HMX3 8209:HMX2 8204:HMX1 8142:LBX2 8137:LBX1 8127:HHEX 7986:MNX1 7981:GBX2 7976:GBX1 7764:Evx2 7759:Evx1 7727:PDX1 7722:Xlox 7612:WRKY 7525:AIRE 7484:804A 7207:ZBTB 7153:SALL 7143:OSR1 7138:MYT1 7133:MTF1 6968:IKZF 6907:REST 6882:GFI1 6877:ERV3 6845:E4F1 6840:CTCF 6629:GATA 6599:DAX1 6579:GCNF 6527:NOR1 6355:HNF4 6224:PPAR 6157:(Cys 6085:AP-2 5955:SMAD 5910:USF1 5883:MXI1 5863:MITF 5856:MXD3 5851:MXD1 5841:AP-4 5816:EBF1 5692:Pho4 5670:BHLH 5549:ARNT 5544:AHRR 5516:TCF4 5511:MXD4 5442:LYL1 5403:OLIG 5357:MYF6 5352:MYF5 5342:MyoD 5315:HAND 5293:AS-C 5275:bHLH 5261:XBP1 5165:GCN4 5145:CREM 5123:CREB 5076:BATF 5059:BACH 5052:JunD 5047:JUNB 5037:JDP2 5022:FOSB 5012:AP-1 4970:AATF 4956:bZIP 4922:and 4859:PMID 4813:PMID 4761:PMID 4720:PMID 4684:PMID 4625:PMID 4576:PMID 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Knowledge (XXG)

Microphthalmia-associated transcription factor

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