1393:, which gives a condition where microtubule formation is not favoured at the front of the cell. For cell migration to occur, a mechanism is needed to decrease the activity of GSK3β to promote growth of microtubules. First, ErbB2 recruits Memo (mediator of ErbB2-driven motility) to the plasma membrane, which then promotes the phosphorylation of GSK3β on serine 9. This decreases the amount of GSK3β activity, and permits the localization of APC and CLASP2 to the cell membrane, which are both microtubule +TIPs. Although CLASP2 is present at the cell membrane, it appears to have a separate, independent mechanism for microtubule growth than APC. When ErbB2 inactivates GSK3β, APC localizes to the membrane and is then able to recruit MACF1 to the membrane as well. The APC-mediated recruitment of MACF1 to the membrane is required and sufficient for microtubule capture and stabilization at the cell cortex during breast carcinoma cell motility.
308:
285:
1365:
occur. It was found in hair follicle stem cells that phosphorylation-refractile MACF1 rescues microtubule architecture from a MACF1 knock-out, whereas phosphorylation-constitutive MACF1 is unable to rescue the phenotype. However, neither phosphorylation-refractile MACF1 nor phosphorylation-constitutive MACF1 are able to rescue polarized cell movement. This implies that the phospho-regulation dynamics permitted in the wild type MACF1 are necessary for polarized cell movement to take place.
182:
207:
573:
566:
559:
314:
213:
1345:, which when uninhibited phosphorylates MACF1 among its many other substrates and uncouples MACF1 from microtubules. The phosphorylation of MACF1 occurs in the GSR domain, which is involved in microtubule binding, and has 32% of the amino acid residues are serines or threonines. MACF1 has 6 serines, which are possible GSK3β phosphorylation sites. GSK3β activity is high in non-stimulated cells, but during
1364:
receptor on the cellular membrane, which then, through a signalling cascade inhibits GSK3β. The inhibition of GSK3β creates a gradient at the leading edge, allowing MACF1 to remain active and unphosphorylated, so that it can form necessary connections between microtubules and actin so migration can
1210:
binding domains, which allow MACF1 to bind to both cytoskeletal elements. MACF1 goes by many names and is also called ACF7 or actin cross-linking factor 7, MACF, macrophin, trabeculin α, and ABP620. Alternatively spliced transcript variants encoding distinct isoforms of MACF1 have been described.
1231:
segment has a +TIP binding site as well as microtubule interacting domains. This allows MACF1 to crosslink both actin and microtubules. The C-terminal region contains both a Gas2-related domain and a GSR-repeat domain, which both are involved with interacting with microtubules. The C-terminus of
1337:
to stall. Wild-type cells with MACF1 present have coordinated cytoskeletal dynamics, which allow for proper cell migration. MACF1 plays an important role in microtubule organization, and without MACF1, microtubules in migrating cells are bending and curly, instead of straight and radial. When
1338:
wounded, conditional knock-outs for MACF1 have around a 40% delay in migration over 4 to 6 days after injury compared to the wild-type controls, showing that MACF1 plays an important role in cell migration. There are suggestions that imply that MACF1 may play a role in golgi polarization.
61:
1528:
Okuda T, Matsuda S, Nakatsugawa S, Ichigotani Y, Iwahashi N, Takahashi M, Ishigaki T, Hamaguchi M (Dec 1999). "Molecular cloning of macrophin, a human homologue of
Drosophila kakapo with a close structural similarity to plectin and dystrophin".
2461:
Kakinuma T, Ichikawa H, Tsukada Y, Nakamura T, Toh BH (2004). "Interaction between p230 and MACF1 is associated with transport of a glycosyl phosphatidyl inositol-anchored protein from the Golgi to the cell periphery".
1377:, a receptor tyrosine, which causes microtubules to form many cell protrusions to cause cell motility. ErbB2 controls microtubule outgrowth and stabilization at the cell cortex through a specific pathway. When
2526:
Gevaert K, Staes A, Van Damme J, De Groot S, Hugelier K, Demol H, Martens L, Goethals M, Vandekerckhove J (2006). "Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC".
2255:
Sun D, Leung CL, Liem RK (2001). "Characterization of the microtubule binding domain of microtubule actin crosslinking factor (MACF): identification of a novel group of microtubule associated proteins".
1236:
subunits. However, MACF1 does not always associate with the microtubule directly, and also binds through many proteins which localize at the microtubule plus end. Such proteins include EB1,
1309:. Also, MACF1 is required for sufficient β-catenin to travel to the nucleus, where subsequently TCF/β-catenin-dependent transcriptional activation of a gene T encoding the protein
321:
220:
2136:"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro"
1313:
occurs. Brachyury is an essential transcription factor required for mesoderm formation. Without MACF1, insufficient brachyury is transcribed, and hence, the
143:
881:
862:
2171:"Microtubule actin cross-linking factor (MACF): a hybrid of dystonin and dystrophin that can interact with the actin and microtubule cytoskeletons"
1469:
1451:
2579:
2574:
2334:"Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs"
1317:
does not form. In fact, MACF1 knock-out mice, which lack the protein, show clear developmental retardation by E7.5, and eventually die at
58:
307:
1102:
1260:
domain, which is approximately 3000 amino acid residues long in the C-terminal region, and is responsible for cytoskeletal dynamics.
1095:
2101:"Molecular cloning and characterization of human trabeculin-alpha, a giant protein defining a new family of actin-binding proteins"
284:
1567:
1438:
1417:
1434:
114:, ABP620, ACF7, MACF, OFC4, microtubule-actin crosslinking factor 1, LIS9, microtubule actin crosslinking factor 1, Lnc-PMIF
206:
181:
1413:
123:
2099:
Sun Y, Zhang J, Kraeft SK, Auclair D, Chang MS, Liu Y, Sutherland R, Salgia R, Griffin JD, Ferland LH, Chen LB (1999).
2418:
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004).
320:
219:
1382:
1302:
313:
212:
1305:. However, upon Wnt signaling, MACF1 is involved in a translation and binding of the axin complex to LTP6 at the
1795:"Skin Stem Cells Orchestrate Directional Migration by Regulating Microtubule-ACF7 Connections through GSK3beta"
926:
131:
907:
1947:"ErbB2 receptor controls microtubule capture by recruiting MACF1 to the plasma membrane of migrating cells"
2294:
1329:
Mice with conditional knock-outs in MACF1 in hair follicle stem cells have defects in cell migration. The
1274:
1245:
2010:"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones"
17:
1958:
1686:"The 'spectraplakins': cytoskeletal giants with characteristics of both spectrin and plakin families"
195:
110:
2299:
1199:
1176:
1029:
1025:
1004:
2285:
Gong TW, Besirli CG, Lomax MI (2002). "MACF1 gene structure: a hybrid of plectin and dystrophin".
2552:
2406:
2320:
1666:
155:
1256:, the ability of MACF1 to bind to microtubules is disrupted. MACF1 also has an actin-regulated
1232:
MACF1 is thought to associate to the microtubule lattice through the acidic C-terminal tails of
1059:
1033:
1000:
996:
2544:
2514:
2493:"Microtubule actin crosslinking factor 1b: a novel plakin that localizes to the Golgi complex"
2479:
2449:
2398:
2363:
2312:
2273:
2243:
2200:
2157:
2122:
2087:
2052:
2031:
1986:
1927:
1878:
1824:
1766:
1717:
1658:
1612:
1546:
1510:
1489:"Novel actin crosslinker superfamily member identified by a two step degenerate PCR procedure"
1192:
572:
565:
558:
103:
51:
1198:
MACF1 belongs to a subset of +TIPs or proteins which bind to growing microtubule ends called
1179:(LRR) domains. MACF1 is a member of a family of proteins that form bridges between different
2584:
2536:
2504:
2471:
2439:
2431:
2388:
2353:
2345:
2304:
2265:
2233:
2225:
2190:
2182:
2147:
2112:
2077:
2021:
1976:
1966:
1917:
1909:
1868:
1860:
1814:
1806:
1756:
1748:
1707:
1697:
1648:
1602:
1594:
1538:
1500:
1278:
400:
331:
275:
230:
1898:"The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway"
1849:"ACF7 regulates cytoskeletal-focal adhesion dynamics and migration and has ATPase activity"
151:
2214:"An epidermal plakin that integrates actin and microtubule networks at cellular junctions"
1330:
1249:
375:
2064:
Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (1998).
1962:
1289:
pathway. When Wnt signalling is not present, MACF1 associates with a complex containing
1248:
assay. Not only does MACF1's C-terminal tail bind to microtubules, but it also has key
2238:
2213:
2195:
2170:
1981:
1946:
1922:
1897:
1873:
1848:
1819:
1794:
1761:
1736:
1607:
1582:
1353:
1346:
1334:
1212:
2444:
2419:
2393:
2376:
2358:
2333:
2066:"Characterization of cDNA clones in size-fractionated cDNA libraries from human brain"
1653:
1636:
796:
791:
786:
781:
776:
771:
766:
761:
756:
751:
746:
730:
725:
720:
715:
710:
705:
700:
695:
690:
685:
669:
664:
659:
654:
649:
644:
639:
634:
629:
624:
619:
614:
2568:
1505:
1488:
1306:
1286:
601:
2410:
2324:
1670:
1318:
1180:
393:
172:
135:
2556:
1294:
159:
2475:
1474:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1456:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1277:. For mice, by embryonic day 7.5 (E7.5), MACF1 is expressed in the headfold and
1203:
1188:
1864:
1810:
1752:
476:
2308:
1598:
1228:
1224:
292:
189:
139:
2152:
2135:
2117:
2100:
2082:
2065:
1321:
due to defects in the formation of the primitive streak, node, and mesoderm.
2026:
2009:
1971:
1793:
Wu X, Shen QT, Oristian DS, Lu CP, Zheng Q, Wang HW, Fuchs E (Feb 4, 2011).
1310:
826:
536:
414:
359:
346:
258:
245:
147:
2548:
2540:
2518:
2483:
2453:
2402:
2367:
2316:
2277:
2247:
2204:
2186:
2161:
2126:
2035:
1990:
1931:
1882:
1828:
1770:
1721:
1662:
1616:
1550:
1542:
2269:
2229:
2091:
2056:
1514:
1191:
interactions at the cell periphery and couples the microtubule network to
1142:
1137:
1378:
1361:
1342:
1314:
1298:
1253:
1172:
1126:
971:
952:
1913:
2435:
2008:
Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (2003).
1282:
1233:
1158:
938:
893:
2509:
2492:
2349:
2134:
Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (2000).
1712:
1702:
1685:
80:
1896:
Chen HJ, Lin CM, Lin CS, Perez-Olle R, Leung CL, Liem RK (Jul 2006).
1390:
1386:
1257:
1241:
1237:
1110:
848:
1281:, and by E8.5 the protein is expressed in neuronal tissues and the
1374:
1357:
1207:
1184:
1333:
in cells lacking MACF1 associate with cables of F-actin, causing
811:
807:
1290:
1165:
581:
127:
2043:
Caccamise DA (1978). "My franchise was a teen-age lion's den".
1223:
MACF1 is an enormous protein of 5380 amino acid residues. The
2375:
Kodama A, Karakesisoglou I, Wong E, Vaezi A, Fuchs E (2004).
1635:
Kodama A, Karakesisoglou I, Wong E, Vaezi A, Fuchs E (2003).
1373:
In breast carcinoma cells, addition of heregulin β activates
2420:"Functional proteomics mapping of a human signaling pathway"
1568:"Entrez Gene: MACF1 microtubule-actin crosslinking factor 1"
1252:
sites. When these sites are phosphorylated by its regulator
1945:
Zaoui K, Benseddik K, Daou P, Salaün D, Badache A (2010).
1155:
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5
1737:"Cell Migration: GSK3beta Steers the Cytoskeleton's Tip"
1244:, whose interactions with MACF1 were determined through
383:
2377:"ACF7: an essential integrator of microtubule dynamics"
1637:"ACF7: An Essential Integrator of Microtubule Dynamics"
2169:
Leung CL, Sun D, Zheng M, Knowles DR, Liem RK (2000).
1487:
Byers TJ, Beggs AH, McNally EM, Kunkel LM (Sep 1995).
1349:
its activity is dampened along the cell leading edge.
2491:
Lin CM, Chen HJ, Leung CL, Parry DA, Liem RK (2006).
1202:. Spectraplakins characteristically have distinctive
548:
1073:
1052:
1018:
989:
1788:
1786:
1784:
1782:
1780:
1430:
1428:
1426:
1409:
1407:
1405:
1171:MACF1 encodes a large protein containing numerous
330:
229:
797:intermediate filament cytoskeleton organization
27:Protein-coding gene in the species Homo sapiens
1842:
1840:
1838:
1435:GRCm38: Ensembl release 89: ENSMUSG00000028649
8:
1356:, but in vitro it is typically inhibited by
1227:segment has an actin binding domain and the
777:positive regulation of Wnt signaling pathway
1630:
1628:
1626:
1414:GRCh38: Ensembl release 89: ENSG00000127603
1360:. Extracellular Wnt signalling acts on the
2212:Karakesisoglou I, Yang Y, Fuchs E (2000).
822:
752:Golgi to plasma membrane protein transport
597:
371:
270:
167:
69:
2508:
2443:
2392:
2357:
2298:
2237:
2194:
2151:
2116:
2081:
2025:
1980:
1970:
1921:
1872:
1818:
1760:
1711:
1701:
1652:
1606:
1504:
1583:"+TIPs: SxIPping along microtubule ends"
1562:
1560:
1352:In vivo, GSK3β activity is inhibited by
1401:
1285:. MACF1 was shown to be present in the
1211:MACF1 is also an important protein for
772:regulation of epithelial cell migration
767:regulation of microtubule-based process
491:paraventricular nucleus of hypothalamus
2332:Nakayama M, Kikuno R, Ohara O (2003).
1684:Röper K, Gregory SL, Brown NH (2002).
1341:The major known regulator of MACF1 is
29:
18:Microtubule actin cross-linking factor
787:regulation of focal adhesion assembly
762:positive regulation of axon extension
335:
296:
291:
234:
193:
188:
7:
1389:are sequentially inactivated by the
1215:in processes such as wound healing.
1183:elements. This protein facilitates
429:dorsal motor nucleus of vagus nerve
1070:
1049:
1015:
986:
962:
943:
917:
898:
872:
853:
553:
471:
409:
388:
25:
1161:that in humans is encoded by the
1847:Wu X, Kodama A, Fuchs E (2008).
571:
564:
557:
319:
312:
306:
283:
218:
211:
205:
180:
2045:Dental Economics – Oral Hygiene
582:More reference expression data
537:More reference expression data
1:
2394:10.1016/S0092-8674(03)00813-4
1654:10.1016/S0092-8674(03)00813-4
655:microtubule minus-end binding
304:
203:
1581:Kumar P, Wittmann T (2012).
1506:10.1016/0014-5793(95)00722-L
782:regulation of cell migration
670:cytoskeletal protein binding
665:structural molecule activity
2580:EF-hand-containing proteins
2575:Genes on human chromosome 1
2476:10.1016/j.yexcr.2004.04.047
2601:
1865:10.1016/j.cell.2008.07.045
1811:10.1016/j.cell.2010.12.033
1753:10.1016/j.cell.2011.01.023
1531:Biochem Biophys Res Commun
2309:10.1007/s00335-001-3037-3
1599:10.1016/j.tcb.2012.05.005
1470:"Mouse PubMed Reference:"
1452:"Human PubMed Reference:"
1141:
1136:
1132:
1125:
1109:
1103:Chr 4: 123.35 – 123.68 Mb
1090:
1077:
1056:
1045:
1022:
993:
982:
969:
965:
950:
946:
937:
924:
920:
905:
901:
892:
879:
875:
860:
856:
847:
832:
825:
821:
805:
792:cytoskeleton organization
600:
596:
579:
556:
547:
534:
483:
474:
421:
412:
382:
374:
370:
353:
340:
303:
282:
273:
269:
252:
239:
202:
179:
170:
166:
121:
118:
108:
101:
96:
77:
72:
55:
50:
45:
41:
37:
32:
2118:10.1074/jbc.274.47.33522
1735:Yucel G, Oro AE (2011).
425:inferior olivary nucleus
1972:10.1073/pnas.1000975107
1273:MACF1 is important for
1096:Chr 1: 39.08 – 39.49 Mb
457:upper lobe of left lung
2541:10.1002/pmic.200401217
2187:10.1083/jcb.147.6.1275
2153:10.1093/dnares/6.5.337
2083:10.1093/dnares/4.5.345
1543:10.1006/bbrc.1999.1538
660:actin filament binding
523:ventral tegmental area
337:4 D2.2|4 57.42 cM
2270:10.1242/jcs.114.1.161
2230:10.1083/jcb.149.1.195
2027:10.1093/dnares/9.3.99
1369:Clinical significance
1275:embryonic development
1269:Embryonic development
1246:coimmunoprecipitation
747:Wnt signaling pathway
726:intermediate filament
449:middle temporal gyrus
507:ventromedial nucleus
298:Chromosome 4 (mouse)
196:Chromosome 1 (human)
73:List of PDB id codes
46:Available structures
1963:2010PNAS..10718517Z
1914:10.1101/gad.1411206
1177:leucine-rich repeat
630:microtubule binding
620:calcium ion binding
503:superior colliculus
441:epithelium of colon
2503:(Pt 16): 3727–38.
2436:10.1101/gr.2334104
1696:(Pt 22): 4215–25.
1193:cellular junctions
927:ENSMUSG00000028649
740:Biological process
731:actin cytoskeleton
679:Cellular component
608:Molecular function
2510:10.1242/jcs.02510
2350:10.1101/gr.406902
2264:(Pt 1): 161–172.
1703:10.1242/jcs.00157
1152:
1151:
1148:
1147:
1121:
1120:
1086:
1085:
1067:
1066:
1041:
1040:
1012:
1011:
978:
977:
959:
958:
933:
932:
914:
913:
888:
887:
869:
868:
817:
816:
615:metal ion binding
592:
591:
588:
587:
543:
542:
530:
529:
519:cerebellar vermis
468:
467:
366:
365:
265:
264:
160:MACF1 - orthologs
92:
91:
88:
87:
56:Ortholog search:
16:(Redirected from
2592:
2560:
2522:
2512:
2487:
2457:
2447:
2414:
2396:
2371:
2361:
2328:
2302:
2281:
2251:
2241:
2208:
2198:
2165:
2155:
2130:
2120:
2111:(47): 33522–30.
2095:
2085:
2060:
2039:
2029:
1995:
1994:
1984:
1974:
1957:(43): 18517–22.
1942:
1936:
1935:
1925:
1893:
1887:
1886:
1876:
1844:
1833:
1832:
1822:
1790:
1775:
1774:
1764:
1732:
1726:
1725:
1715:
1705:
1681:
1675:
1674:
1656:
1632:
1621:
1620:
1610:
1587:Trends Cell Biol
1578:
1572:
1571:
1564:
1555:
1554:
1525:
1519:
1518:
1508:
1484:
1478:
1477:
1466:
1460:
1459:
1448:
1442:
1432:
1421:
1411:
1279:primitive streak
1134:
1133:
1105:
1098:
1081:
1071:
1062:
1050:
1046:RefSeq (protein)
1036:
1016:
1007:
987:
963:
944:
918:
899:
873:
854:
823:
645:cadherin binding
598:
584:
575:
568:
561:
554:
539:
479:
477:Top expressed in
472:
461:ventricular zone
417:
415:Top expressed in
410:
389:
372:
362:
349:
338:
323:
316:
310:
299:
287:
271:
261:
248:
237:
222:
215:
209:
198:
184:
168:
162:
113:
106:
83:
70:
64:
43:
42:
30:
21:
2600:
2599:
2595:
2594:
2593:
2591:
2590:
2589:
2565:
2564:
2563:
2535:(14): 3589–99.
2525:
2490:
2460:
2417:
2374:
2344:(11): 1773–84.
2331:
2300:10.1.1.495.6352
2284:
2254:
2211:
2168:
2133:
2098:
2063:
2042:
2007:
2003:
2001:Further reading
1998:
1944:
1943:
1939:
1908:(14): 1933–45.
1895:
1894:
1890:
1846:
1845:
1836:
1792:
1791:
1778:
1734:
1733:
1729:
1683:
1682:
1678:
1634:
1633:
1624:
1580:
1579:
1575:
1566:
1565:
1558:
1527:
1526:
1522:
1486:
1485:
1481:
1468:
1467:
1463:
1450:
1449:
1445:
1433:
1424:
1412:
1403:
1399:
1371:
1331:focal adhesions
1327:
1271:
1266:
1250:phosphorylation
1221:
1143:View/Edit Mouse
1138:View/Edit Human
1101:
1094:
1091:Location (UCSC)
1079:
1058:
1032:
1028:
1024:
1003:
999:
995:
908:ENSG00000127603
801:
735:
711:plasma membrane
706:ruffle membrane
691:cell projection
686:Golgi apparatus
674:
650:ATPase activity
635:protein binding
580:
570:
569:
563:
562:
535:
526:
521:
517:
515:right lung lobe
513:
511:arcuate nucleus
509:
505:
501:
497:
495:mammillary body
493:
489:
475:
464:
459:
455:
451:
447:
445:corpus callosum
443:
439:
437:Achilles tendon
435:
431:
427:
413:
357:
344:
336:
326:
325:
324:
317:
297:
274:Gene location (
256:
243:
235:
225:
224:
223:
216:
194:
171:Gene location (
122:
109:
102:
79:
57:
28:
23:
22:
15:
12:
11:
5:
2598:
2596:
2588:
2587:
2582:
2577:
2567:
2566:
2562:
2561:
2523:
2488:
2458:
2430:(7): 1324–32.
2415:
2372:
2329:
2293:(11): 852–61.
2282:
2252:
2224:(1): 195–208.
2209:
2181:(6): 1275–86.
2166:
2131:
2096:
2061:
2040:
2004:
2002:
1999:
1997:
1996:
1937:
1888:
1834:
1776:
1727:
1676:
1622:
1573:
1556:
1520:
1479:
1461:
1443:
1422:
1400:
1398:
1395:
1370:
1367:
1354:Wnt signalling
1347:cell migration
1335:cell migration
1326:
1325:Cell migration
1323:
1270:
1267:
1265:
1262:
1220:
1217:
1213:cell migration
1200:spectraplakins
1150:
1149:
1146:
1145:
1140:
1130:
1129:
1123:
1122:
1119:
1118:
1116:
1114:
1107:
1106:
1099:
1092:
1088:
1087:
1084:
1083:
1075:
1074:
1068:
1065:
1064:
1054:
1053:
1047:
1043:
1042:
1039:
1038:
1020:
1019:
1013:
1010:
1009:
991:
990:
984:
980:
979:
976:
975:
967:
966:
960:
957:
956:
948:
947:
941:
935:
934:
931:
930:
922:
921:
915:
912:
911:
903:
902:
896:
890:
889:
886:
885:
877:
876:
870:
867:
866:
858:
857:
851:
845:
844:
839:
834:
830:
829:
819:
818:
815:
814:
803:
802:
800:
799:
794:
789:
784:
779:
774:
769:
764:
759:
754:
749:
743:
741:
737:
736:
734:
733:
728:
723:
718:
713:
708:
703:
698:
693:
688:
682:
680:
676:
675:
673:
672:
667:
662:
657:
652:
647:
642:
637:
632:
627:
622:
617:
611:
609:
605:
604:
594:
593:
590:
589:
586:
585:
577:
576:
551:
545:
544:
541:
540:
532:
531:
528:
527:
525:
524:
520:
516:
512:
508:
504:
500:
496:
492:
488:
487:left lung lobe
484:
481:
480:
469:
466:
465:
463:
462:
458:
454:
453:saphenous vein
450:
446:
442:
438:
434:
430:
426:
422:
419:
418:
406:
405:
397:
386:
380:
379:
376:RNA expression
368:
367:
364:
363:
355:
351:
350:
342:
339:
334:
328:
327:
318:
311:
305:
301:
300:
295:
289:
288:
280:
279:
267:
266:
263:
262:
254:
250:
249:
241:
238:
233:
227:
226:
217:
210:
204:
200:
199:
192:
186:
185:
177:
176:
164:
163:
120:
116:
115:
107:
99:
98:
94:
93:
90:
89:
86:
85:
75:
74:
66:
65:
54:
48:
47:
39:
38:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
2597:
2586:
2583:
2581:
2578:
2576:
2573:
2572:
2570:
2558:
2554:
2550:
2546:
2542:
2538:
2534:
2530:
2524:
2520:
2516:
2511:
2506:
2502:
2498:
2494:
2489:
2485:
2481:
2477:
2473:
2470:(2): 388–98.
2469:
2465:
2464:Exp. Cell Res
2459:
2455:
2451:
2446:
2441:
2437:
2433:
2429:
2425:
2421:
2416:
2412:
2408:
2404:
2400:
2395:
2390:
2387:(3): 343–54.
2386:
2382:
2378:
2373:
2369:
2365:
2360:
2355:
2351:
2347:
2343:
2339:
2335:
2330:
2326:
2322:
2318:
2314:
2310:
2306:
2301:
2296:
2292:
2288:
2283:
2279:
2275:
2271:
2267:
2263:
2259:
2253:
2249:
2245:
2240:
2235:
2231:
2227:
2223:
2219:
2215:
2210:
2206:
2202:
2197:
2192:
2188:
2184:
2180:
2176:
2172:
2167:
2163:
2159:
2154:
2149:
2146:(5): 337–45.
2145:
2141:
2137:
2132:
2128:
2124:
2119:
2114:
2110:
2106:
2105:J. Biol. Chem
2102:
2097:
2093:
2089:
2084:
2079:
2075:
2071:
2067:
2062:
2058:
2054:
2051:(11): 36–43.
2050:
2046:
2041:
2037:
2033:
2028:
2023:
2020:(3): 99–106.
2019:
2015:
2011:
2006:
2005:
2000:
1992:
1988:
1983:
1978:
1973:
1968:
1964:
1960:
1956:
1952:
1948:
1941:
1938:
1933:
1929:
1924:
1919:
1915:
1911:
1907:
1903:
1899:
1892:
1889:
1884:
1880:
1875:
1870:
1866:
1862:
1859:(1): 137–48.
1858:
1854:
1850:
1843:
1841:
1839:
1835:
1830:
1826:
1821:
1816:
1812:
1808:
1805:(3): 341–52.
1804:
1800:
1796:
1789:
1787:
1785:
1783:
1781:
1777:
1772:
1768:
1763:
1758:
1754:
1750:
1747:(3): 319–21.
1746:
1742:
1738:
1731:
1728:
1723:
1719:
1714:
1709:
1704:
1699:
1695:
1691:
1687:
1680:
1677:
1672:
1668:
1664:
1660:
1655:
1650:
1647:(3): 343–54.
1646:
1642:
1638:
1631:
1629:
1627:
1623:
1618:
1614:
1609:
1604:
1600:
1596:
1593:(8): 418–28.
1592:
1588:
1584:
1577:
1574:
1569:
1563:
1561:
1557:
1552:
1548:
1544:
1540:
1537:(2): 568–74.
1536:
1532:
1524:
1521:
1516:
1512:
1507:
1502:
1498:
1494:
1490:
1483:
1480:
1475:
1471:
1465:
1462:
1457:
1453:
1447:
1444:
1440:
1436:
1431:
1429:
1427:
1423:
1419:
1415:
1410:
1408:
1406:
1402:
1396:
1394:
1392:
1388:
1384:
1380:
1376:
1368:
1366:
1363:
1359:
1355:
1350:
1348:
1344:
1339:
1336:
1332:
1324:
1322:
1320:
1316:
1312:
1308:
1307:cell membrane
1304:
1300:
1296:
1292:
1288:
1287:Wnt signaling
1284:
1280:
1276:
1268:
1263:
1261:
1259:
1255:
1251:
1247:
1243:
1239:
1235:
1230:
1226:
1218:
1216:
1214:
1209:
1205:
1201:
1196:
1194:
1190:
1186:
1182:
1178:
1174:
1169:
1167:
1164:
1160:
1156:
1144:
1139:
1135:
1131:
1128:
1124:
1117:
1115:
1112:
1108:
1104:
1100:
1097:
1093:
1089:
1082:
1076:
1072:
1069:
1063:
1061:
1055:
1051:
1048:
1044:
1037:
1035:
1031:
1027:
1021:
1017:
1014:
1008:
1006:
1002:
998:
992:
988:
985:
983:RefSeq (mRNA)
981:
974:
973:
968:
964:
961:
955:
954:
949:
945:
942:
940:
936:
929:
928:
923:
919:
916:
910:
909:
904:
900:
897:
895:
891:
884:
883:
878:
874:
871:
865:
864:
859:
855:
852:
850:
846:
843:
840:
838:
835:
831:
828:
824:
820:
813:
809:
804:
798:
795:
793:
790:
788:
785:
783:
780:
778:
775:
773:
770:
768:
765:
763:
760:
758:
757:wound healing
755:
753:
750:
748:
745:
744:
742:
739:
738:
732:
729:
727:
724:
722:
719:
717:
714:
712:
709:
707:
704:
702:
699:
697:
694:
692:
689:
687:
684:
683:
681:
678:
677:
671:
668:
666:
663:
661:
658:
656:
653:
651:
648:
646:
643:
641:
638:
636:
633:
631:
628:
626:
625:actin binding
623:
621:
618:
616:
613:
612:
610:
607:
606:
603:
602:Gene ontology
599:
595:
583:
578:
574:
567:
560:
555:
552:
550:
546:
538:
533:
522:
518:
514:
510:
506:
502:
498:
494:
490:
486:
485:
482:
478:
473:
470:
460:
456:
452:
448:
444:
440:
436:
432:
428:
424:
423:
420:
416:
411:
408:
407:
404:
402:
398:
396:
395:
391:
390:
387:
385:
381:
377:
373:
369:
361:
356:
352:
348:
343:
333:
329:
322:
315:
309:
302:
294:
290:
286:
281:
277:
272:
268:
260:
255:
251:
247:
242:
232:
228:
221:
214:
208:
201:
197:
191:
187:
183:
178:
174:
169:
165:
161:
157:
153:
149:
145:
141:
137:
133:
129:
125:
117:
112:
105:
100:
95:
84:
82:
76:
71:
68:
67:
63:
60:
53:
49:
44:
40:
36:
31:
19:
2532:
2528:
2500:
2496:
2467:
2463:
2427:
2423:
2384:
2380:
2341:
2337:
2290:
2287:Mamm. Genome
2286:
2261:
2257:
2221:
2218:J. Cell Biol
2217:
2178:
2175:J. Cell Biol
2174:
2143:
2139:
2108:
2104:
2076:(5): 345–9.
2073:
2069:
2048:
2044:
2017:
2013:
1954:
1950:
1940:
1905:
1901:
1891:
1856:
1852:
1802:
1798:
1744:
1740:
1730:
1693:
1689:
1679:
1644:
1640:
1590:
1586:
1576:
1534:
1530:
1523:
1499:(3): 500–4.
1496:
1492:
1482:
1473:
1464:
1455:
1446:
1372:
1351:
1340:
1328:
1319:gastrulation
1272:
1222:
1197:
1181:cytoskeletal
1170:
1162:
1154:
1153:
1078:
1057:
1030:NM_001199137
1026:NM_001199136
1023:
1005:NM_001394062
994:
970:
951:
925:
906:
880:
861:
841:
836:
716:cytoskeleton
399:
392:
358:123,684,360
345:123,349,633
119:External IDs
78:
2497:J. Cell Sci
2258:J. Cell Sci
1690:J. Cell Sci
1381:is active,
1204:microtubule
1189:microtubule
701:microtubule
640:RNA binding
257:39,487,177
244:39,081,316
97:Identifiers
2569:Categories
2529:Proteomics
2424:Genome Res
2338:Genome Res
1713:2440/41876
1441:, May 2017
1420:, May 2017
1397:References
1229:C-terminal
1225:N-terminal
499:right lung
433:right lung
403:(ortholog)
140:HomoloGene
2295:CiteSeerX
1902:Genes Dev
1493:FEBS Lett
1311:brachyury
1295:β-catenin
1219:Structure
1060:NP_036222
1034:NM_009600
1001:NM_033044
997:NM_012090
827:Orthologs
721:cytoplasm
148:GeneCards
2549:16097034
2519:16076900
2484:15265687
2454:15231748
2403:14636561
2368:12421765
2317:11845288
2278:11112700
2248:10747097
2205:10601340
2162:10574462
2127:10559237
2036:12168954
1991:20937854
1932:16815997
1883:18854161
1829:21295697
1771:21295692
1722:12376554
1663:14636561
1617:22748381
1551:10529403
1437:–
1416:–
1362:Frizzled
1315:mesoderm
1264:Function
1173:spectrin
1127:Wikidata
806:Sources:
696:membrane
2585:Plakins
2411:5249501
2325:8121128
2239:2175090
2196:2168091
2140:DNA Res
2092:9455484
2070:DNA Res
2057:1074709
2014:DNA Res
1982:2972954
1959:Bibcode
1923:1522081
1874:2703712
1820:3050560
1762:3929416
1671:5249501
1608:3408562
1515:7635207
1439:Ensembl
1418:Ensembl
1283:foregut
1234:tubulin
1159:protein
939:UniProt
894:Ensembl
833:Species
812:QuickGO
378:pattern
104:Aliases
2557:895879
2555:
2547:
2517:
2482:
2452:
2445:442148
2442:
2409:
2401:
2366:
2359:187542
2356:
2323:
2315:
2297:
2276:
2246:
2236:
2203:
2193:
2160:
2125:
2090:
2055:
2034:
1989:
1979:
1930:
1920:
1881:
1871:
1827:
1817:
1769:
1759:
1720:
1669:
1661:
1615:
1605:
1549:
1513:
1391:kinase
1387:CLASP2
1301:, and
1258:ATPase
1242:CLASP2
1240:, and
1238:CLASP1
1113:search
1111:PubMed
972:Q9QXZ0
953:Q9UPN3
849:Entrez
549:BioGPS
236:1p34.3
144:136220
136:108559
128:608271
2553:S2CID
2407:S2CID
2321:S2CID
1667:S2CID
1379:GSK3β
1375:ErbB2
1358:cdc42
1343:GSK3β
1299:GSK3β
1254:GSK3β
1208:actin
1185:actin
1163:MACF1
1157:is a
882:11426
863:23499
842:Mouse
837:Human
808:Amigo
401:Mouse
394:Human
341:Start
276:Mouse
240:Start
173:Human
152:MACF1
111:MACF1
33:MACF1
2545:PMID
2515:PMID
2480:PMID
2450:PMID
2399:PMID
2381:Cell
2364:PMID
2313:PMID
2274:PMID
2244:PMID
2201:PMID
2158:PMID
2123:PMID
2088:PMID
2053:PMID
2032:PMID
1987:PMID
1951:PNAS
1928:PMID
1879:PMID
1853:Cell
1825:PMID
1799:Cell
1767:PMID
1741:Cell
1718:PMID
1659:PMID
1641:Cell
1613:PMID
1547:PMID
1511:PMID
1385:and
1291:axin
1206:and
1175:and
1166:gene
384:Bgee
332:Band
293:Chr.
231:Band
190:Chr.
124:OMIM
81:4Z6G
62:RCSB
59:PDBe
2537:doi
2505:doi
2501:118
2472:doi
2468:298
2440:PMC
2432:doi
2389:doi
2385:115
2354:PMC
2346:doi
2305:doi
2266:doi
2262:114
2234:PMC
2226:doi
2222:149
2191:PMC
2183:doi
2179:147
2148:doi
2113:doi
2109:274
2078:doi
2022:doi
1977:PMC
1967:doi
1955:107
1918:PMC
1910:doi
1869:PMC
1861:doi
1857:135
1815:PMC
1807:doi
1803:144
1757:PMC
1749:doi
1745:144
1708:hdl
1698:doi
1694:115
1649:doi
1645:115
1603:PMC
1595:doi
1539:doi
1535:264
1501:doi
1497:368
1383:APC
1303:APC
1080:n/a
354:End
253:End
156:OMA
132:MGI
52:PDB
2571::
2551:.
2543:.
2531:.
2513:.
2499:.
2495:.
2478:.
2466:.
2448:.
2438:.
2428:14
2426:.
2422:.
2405:.
2397:.
2383:.
2379:.
2362:.
2352:.
2342:12
2340:.
2336:.
2319:.
2311:.
2303:.
2291:12
2289:.
2272:.
2260:.
2242:.
2232:.
2220:.
2216:.
2199:.
2189:.
2177:.
2173:.
2156:.
2142:.
2138:.
2121:.
2107:.
2103:.
2086:.
2072:.
2068:.
2049:66
2047:.
2030:.
2016:.
2012:.
1985:.
1975:.
1965:.
1953:.
1949:.
1926:.
1916:.
1906:20
1904:.
1900:.
1877:.
1867:.
1855:.
1851:.
1837:^
1823:.
1813:.
1801:.
1797:.
1779:^
1765:.
1755:.
1743:.
1739:.
1716:.
1706:.
1692:.
1688:.
1665:.
1657:.
1643:.
1639:.
1625:^
1611:.
1601:.
1591:22
1589:.
1585:.
1559:^
1545:.
1533:.
1509:.
1495:.
1491:.
1472:.
1454:.
1425:^
1404:^
1297:,
1293:,
1195:.
1168:.
810:/
360:bp
347:bp
259:bp
246:bp
154:;
150::
146:;
142::
138:;
134::
130:;
126::
2559:.
2539::
2533:5
2521:.
2507::
2486:.
2474::
2456:.
2434::
2413:.
2391::
2370:.
2348::
2327:.
2307::
2280:.
2268::
2250:.
2228::
2207:.
2185::
2164:.
2150::
2144:6
2129:.
2115::
2094:.
2080::
2074:4
2059:.
2038:.
2024::
2018:9
1993:.
1969::
1961::
1934:.
1912::
1885:.
1863::
1831:.
1809::
1773:.
1751::
1724:.
1710::
1700::
1673:.
1651::
1619:.
1597::
1570:.
1553:.
1541::
1517:.
1503::
1476:.
1458:.
1187:-
278:)
175:)
158::
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
