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In 2005, Radulovacki established the
Miodrag Radulovacki Family Prize for Excellence in Basic Sciences at the University of Illinois College of Medicine at Chicago. The purpose of the prize, given annually, is to honor a fourth year Medical student who displays a high degree of intellectual integrity
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Radulovacki was named the 2010 Inventor of the Year at the
University of Illinois, alongside Carley. Radulovacki and Carley were honored by the University of Illinois for producing a dozen potential treatments for sleep apnea, many of which are now under consideration for commercial development.
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Radulovacki reasoned that if the blocking of adenosine receptors produces excitation, then perhaps stimulation of the same receptors could induce sleep. He knew that experiments by John
Phillis and his group (Can. J. Physiol. Pharmacol. 57:1289-1312, 1979), which utilized an
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In 1970, Radulovacki was recruited by Klaus Unna to join the
Department of Pharmacology in the College of Medicine at the University of Illinois at Chicago as an Assistant Professor. Radulovacki published more than 170 scientific papers during his career at the UIC.
563:
In
October 2003, the Serbian Academy of Sciences and Arts in Belgrade elected Radulovacki as one of its Foreign Members for his significant scientific research contributions in the fields of Neuropharmacology, sleep disorders and sleep-related breathing disorders.
662:. Radulovacki died on May 27, 2014, in Belgrade, Serbia, while on two-week trip to promote his philanthropic projects. He is survived by two sons (Brad Radulovacki and Branko Radulovacki) and four grandchildren (Grant, Katie, Reid and Ryan).
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for the treatment of sleep apnea which have been patented by the UIC. The UIC recognized them as the 2010 "Inventors of the Year." Radulovacki published more than 170 scientific papers. Radulovacki was also a
Foreign Member of the
479:, widely believed to be a sleep inducing agent. However, since there was no suggestion how this adenosine-serotonin link was achieved, experiments highlighting the potential role of adenosine in sleep had largely been forgotten.
521:"Hypnotic Composition and Method of Inducing Sleep"; Inventor: Miodrag Radulovacki, US Patent 4537907, August 27, 1985. (This patent was issued to UIC before Radulovacki started his collaboration with Carley in 1993).
2194:
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Radulovacki, M; Buckingham, RL; Chen, EH; Kovacević, R (1977). "Similar effects of tryptophan and sleep on cisternal cerebrospinal fluid 5-hydroxyindoleacetic and homovanillic acids in cats".
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as the sleep inducing agent, was dominant at the time. From 1970 to 1984, at the
University of Illinois, Radulovacki published a series of papers dealing with the role of monoamines in sleep.
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545:"Pharmacological treatments for sleep disorders (apnoe) with prostanoid receptor antagonists", Inventors: David W. Carley and Miodrag Radulovacki, US Patent 8,076,315, Dec. 13, 2011.
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of sleep apnea in rats, initially testing the effects of adenosine compounds. Eventually, they obtained positive results using serotonin and other compounds. As a result, the UIC
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542:"Methods for treating sleep disorders by cholecystokinin (CCK) receptor B antagonists": Inventors: David W. Carley and Miodrag Radulovacki, US Patent 8,053,413 B2, Nov. 8, 2011.
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Phillis, J. W.; Edstrom, J. P.; Kostopoulos, G. K.; Kirkpatrick, J. R. (1979). "Effects of adenosine and adenine nucleotides on synaptic transmission in the cerebral cortex".
1237:
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In 1984, Radulovacki postulated the
Adenosine Sleep Theory, (JPET, 228: 268-274, 1984). The idea for adenosine's role in sleep occurred to him after reading a paper by
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in the courtyard of the
Karlovci Ecological Center. In recognition of Radulovacki's philanthropy, the ecological center was renamed the Ecological Center Radulovački.
533:"Neuropharmacological Treatment of Sleep-Related Breathing Disorders"; Inventors: Miodrag Radulovacki and David W. Carley, US Patent 6,974,814 B2, December 13, 2005.
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527:"Neuropharmacological Treatments of Sleep-Related Breathing Disorders"; Inventors: Miodrag Radulovacki and David W. Carley, US Patent 6,555,564 B1, April 29, 2003.
555:
Their results have culminated in an
IllinoisVentures-supported start-up company, Pier Pharmaceuticals, that focuses on the treatment of obstructive sleep apnea.
1976:
2189:
464:(J. Neurochem. 21:,1019–20, 1973) and the administration of adenosine into the brains of rats, cats and fowl suggested that adenosine was able to produce
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Buckingham, RL; Radulovacki, M (1975). "The selective effects of alpha-methyl aromatic amino acids on brain monoamine metabolites and behavior in cats".
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In 2009, Radulovacki restored the baroque façades of the Ecological Center in Karlovci which occupies a historic building in the center of the town.
1956:"Pharmacological treatments for sleep disorders (apnoe) with prostanoid receptor antagonists": Inventors: David W. Carley and Miodrag Radulovacki.
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in the brain of cats. The cannulation method enabled researchers to obtain cerebrospinal fluid during sleep and wakefulness for the analysis of
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Haulicǎ, I.; Ababei, L.; Brǎnişlteanu, D.; Topoliceanu, F. (October 1973). "Preliminary data on the possible hypnogenic role of adenosine".
1945:"Methods for treating sleep disorders by cholecystokinin (CCK) receptor B antagonists": Inventors: David W. Carley and Miodrag Radulovacki.
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524:"Pharmacological Treatment for Sleep Apnea"; Inventors: Miodrag Radulovacki and David W. Carley, US Patent 6,331,536 B1, December 18, 2001.
242:
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Radulovacki, M (1973). "5-Hydroxyindoleacetic acid in cerebrospinal fluid: Measurements in wakefulness, slow-wave and paradoxical sleep".
536:"Pharmacological Treatment for Sleep Apnea"; Inventors: Miodrag Radulovacki and David W. Carley, US Patent 7,160,898 B2, January 9, 2007.
530:"Pharmacological Treatment for Sleep Apnea"; Inventors: Miodrag Radulovacki and David W. Carley, US Patent 6,727,242 B2, April 27, 2004.
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Summary biography of Miodrag Radulovacki, Illinois Medicine Fiscal Year 2009 Report - Honor Roll of Donors, page 27 (Prizing Discovery)
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236:, together with research collaborator, David W. Carley, (Professor of Medicine at the UIC). Radulovacki and Carley invented several
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539:"Method for Treating Sleep Apnea"; Inventors: David W. Carley and Miodrag Radulovacki, US Patent 7,705,039 B2, April 27, 2010.
1958:
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424:'s group (Proc. Natl. Acad. Sci, 78: 3260-64, 1981) about the importance of adenosine receptors in the behavioral actions of
1883:"Neuropharmacological Treatments of Sleep-Related Breathing Disorders"; Inventors: Miodrag Radulovacki and David W. Carley.
1912:"Neuropharmacological Treatment of Sleep-Related Breathing Disorders"; Inventors: Miodrag Radulovacki and David W. Carley.
994:"Prospective trial of efficacy and safety of ondansetron and fluoxetine in patients with obstructive sleep apnea syndrome"
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and Pharmacology at the UIC. Their research efforts focused on developing pharmacological approaches for the treatment of
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Stone, KL; Ewing, SK; Ancoli-Israel, S; Ensrud, KE; Redline, S; Bauer, DC; Cauley, JA; Hillier, TA; Cummings, SR (2009).
341:(UCLA) Brain Research Institute where his mentor was Ross Adey. One of the findings of his research at UCLA was that the
655:
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1128:"Faculty Research: Miodrag Radulovacki, MD, PhD Professor of Pharmacology and Medicine-Respiratory and Critical Care"
963:
Carley, DW; Radulovacki, M (1999). "Role of peripheral serotonin in the regulation of central sleep apneas in rats".
334:. The topic of his PhD thesis was: "Sleep in Split-Brain Cats," partly done at the Brain Research Institute at UCLA.
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News report about the restoration of the Branko Radičević monument by Miodrag Radulovacki on Serbian TV station PTB1
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580:(UIUC) after the creation of International Linkage Agreements between the UIC and the Universities of Belgrade and
1973:
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1359:"Our Foreigners" Weekly Television Program on Serbian station PTB1, Part 2: Biography of Dr. Miodrag Radulovacki
1333:"Our Foreigners" Weekly Television Program on Serbian station PTB1, Part 1: Biography of Dr. Miodrag Radulovacki
1441:
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Radulovacki, M; Zak, R (1981). "Amphetamine abolishes REM sleep rebound in rats: Effect of single injection".
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and who has demonstrated strong academic achievement. The prize consists of a plaque and a check for $ 1,000.
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effects of adenosine were shown to be inhibitory. In addition, the preliminary experiments in dogs by Haulica
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or "Gymnasium," which is the oldest high school in Serbia. Radulovacki called Karlovci Gymnasium the "Serbian
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Picture of renovated baroque facade of the Ecological Center in Karlovci, Ecological Center Karlovci web site
1994:
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Radulovacki, M; Virus, RM; Djuricic-Nedelson, M; Green, RD (1984). "Adenosine analogs and sleep in rats".
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499:. Since there were no medicines to alleviate this condition, Radulovacki and Carley set out to develop a
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Radulovacki graduated from the University of Belgrade School of Medicine in 1959. He went on to obtain a
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after his mother accepted a teaching position in the town. Sremski Karlovci (also known as Karlovci), a
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45:
1457:"Hippocampal states and functional relations with corticosubcortical systems in attention and learning"
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Kovacević, R; Radulovacki, M (1976). "Monoamine changes in the brain of cats during slow-wave sleep".
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1438:"In Memoriam: William Ross Adey, M.D., Professor of Anatomy and Physiology, Los Angeles, 1922–2004"
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658:. He participated in several Birkebeiner-Kortelopet cross-country ski marathons in Cable-Hayward,
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in Yugoslavia. The Yugoslav Student Summer Program lasted for 12 years and had 304 participants.
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1923:"Pharmacological Treatment for Sleep Apnea"; Inventors: Miodrag Radulovacki and David W. Carley.
1901:"Pharmacological Treatment for Sleep Apnea"; Inventors: Miodrag Radulovacki and David W. Carley.
1865:"Pharmacological Treatment for Sleep Apnea"; Inventors: Miodrag Radulovacki and David W. Carley.
124:
Student Summer Program at the University of Illinois at Chicago and Champaign-Urbana, 1990-2000
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Radulovacki, M; Walovitch, R; Yanik, G (1980). "Caffeine produces REM sleep rebound in rats".
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In 2011, Radulovacki financed the construction of a self-sustaining ecological building with
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In 2007, Radulovacki restored the symbol of Sremski Karlovci, a baroque fountain called the
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1283:"Miodrag Radulovacki partial list of research publications, UIC Department of Pharmacology"
1073:"Self-reported sleep and nap habits and risk of mortality in a large cohort of older women"
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1998:
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1934:"Method for Treating Sleep Apnea"; Inventors: David W. Carley and Miodrag Radulovacki.
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1962:
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Radulovacki, M.; Virus, R. M.; Djuricic-Nedelson, M.; Green, R. D. (February 1984).
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1854:"Hypnotic Composition and Method of Inducing Sleep"; Inventor: Miodrag Radulovacki.
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295:, had been home to the Radulovacki family for over 200 years. Radulovacki attended
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Prasad, B; Radulovacki, M; Olopade, C; Herdegen, JJ; Logan, T; Carley, DW (2010).
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In 1993, Radulovacki started a collaboration with David W. Carley, a Professor of
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Ecological Center Karlovci newsletter and update on the new construction project
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Sleep-related Breathing Disorders: Experimental Models And Therapeutic Potential
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Proceedings of the National Academy of Sciences of the United States of America
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Snyder, S. H.; Katims, J. J.; Annau, Z.; Bruns, R. F.; Daly, J. W. (May 1981).
930:"Serotonin 5-HT3-receptor antagonist GR 38032F suppresses sleep apneas in rats"
428:. In the article, the authors correlated the behavioral excitation produced by
311:
of the Karlovci High School Class of 1951. Radulovacki gained admission to the
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1933:
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622:(Strazhilovo) which is located on a mountain-top surrounded by forests in the
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Sleep Theory, and (2) pioneering pharmacological studies for the treatment of
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Carley, D. W.; Olopade, C.; Ruigt, G. S.; Radulovacki, M. (January 2007).
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In 1990, Radulovacki initiated the Yugoslav Student Summer Program at the
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Ryan, CM; Bradley, TD (2005). "Pathogenesis of obstructive sleep apnea".
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1262:. UIC Office of Technology Management. February 8, 2011. Archived from
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1991:
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Radulovacki, M (2005). "Adenosine sleep theory: How I postulated it".
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their discoveries, obtaining numerous US and international patents.
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application of adenosine in the brain, had demonstrated adenosine's
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Patents by the UIC, Pharmacological Treatments for Sleep Disorders.
1414:
University of Illinois Department of Pharmacology Faculty Profiles
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369:
187:
2010:
The Yugoslav Student Summer Program at the University of Illinois
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1589:"Adenosine receptors and behavioral actions of methylxanthines"
228:(UIC), Radulovacki's research accomplishments include: (1) the
56:
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Research Communications in Chemical Pathology and Pharmacology
327:
165:, Sleep and sleep disorders, Sleep-related breathing disorders
1777:"Efficacy of mirtazapine in obstructive sleep apnea syndrome"
1238:"Meet the winners of the UIC 2010 Inventor of the Year Award"
870:
Radulovacki, M (1985). "Role of adenosine in sleep in rats".
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In 2010, Radulovacki restored the monument of Serbian poet,
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Radulovacki made numerous contributions to his home town of
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College of Medicine at the University of Illinois at Chicago
193:
College of Medicine at the University of Illinois at Chicago
140:
College of Medicine at the University of Illinois at Chicago
1424:
360:
In 1966, Radulovacki accepted a teaching position with the
2114:"Blic Online | Preminuo akademik Miodrag Radulovački"
1652:. In Stefanovich, Vladimir; Okyayuz-Baklouti, I. (eds.).
851:
The Journal of Pharmacology and Experimental Therapeutics
1654:
Role of adenosine in cerebral metabolism and blood flow
1400:
University of Illinois, Dr. Miodrag Radulovacki profile
517:
Patents for sleep and sleep-related disorders include:
345:(EEG) pattern of sleep in cats with split brain to the
126:
The Miodrag Radulovacki Family Prize for Excellence in
559:
Membership in the Serbian Academy of Sciences and Arts
1816:
Carley, David W.; Radulovacki, Miodrag (2002-12-12).
1762:
University of Illinois at Chicago College of Medicine
1561:
Journal of Pharmacology and Experimental Therapeutics
1195:
University of Illinois at Chicago (October 5, 2004).
2195:
Members of the Serbian Academy of Sciences and Arts
576:at Chicago (UIC) and the University of Illinois at
253:Miodrag Radulovacki was born on April 28, 1933, in
169:
158:
134:
104:
92:
81:
73:
52:
34:
18:
2170:University of Belgrade Faculty of Medicine alumni
1535:"Klaus Unna, 79, U. Of I. Pharmacology Professor"
1459:. In Adey, W. Ross; Tokizane, Toshihiko (eds.).
928:Radulovacki, M; Trbovic, SM; Carley, DW (1998).
1680:Canadian Journal of Physiology and Pharmacology
1409:
1407:
1306:"Miodrag Radulovacki, MD, PhD, Foreign Member"
456:in several brain regions and that the general
436:concentrations with the blockade of adenosine
372:. There he invented an approach for obtaining
2021:Yugoslav Student Summer Program, Participants
1260:"UIC OTM Announces 2010 Inventor of the Year"
1147:"Adenosine Sleep Theory: How I postulated it"
364:Department in the College of Medicine at the
276:and was later taken prisoner by the invading
220:scientist and inventor. He was Professor of
8:
2200:Academic staff of the University of Khartoum
1353:
1351:
1349:
1347:
1345:
872:Reviews in Clinical & Basic Pharmacology
608:, located in the central square of the city.
272:, Radulovacki's father was drafted into the
1974:UIC OTM Announces 2010 Inventor of the Year
1461:Structure and function of the limbic system
1379:
1377:
1375:
1373:
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483:Research collaboration with David W. Carley
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1132:University of Illinois College of Medicine
1077:Journal of the American Geriatrics Society
26:
15:
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475:effect was through its interaction with
2165:Yugoslav emigrants to the United States
1992:Pier Pharmaceuticals web site Home Page
1119:
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1393:
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1300:
1298:
1277:
1275:
1273:
1217:"Faculty profile: Dr. David W. Carley"
391:. This approach was of interest since
1556:"Adenosine analogs and sleep in rats"
339:University of California, Los Angeles
181:– Brain Research Institute, 1964-1965
7:
1310:Serbian Academy of Sciences and Arts
1197:"Novel Drug Therapy for Sleep Apnea"
503:. Their initial work focussed on an
243:Serbian Academy of Sciences and Arts
145:Serbian Academy of Sciences and Arts
130:at the UIC College of Medicine, 2005
1244:. February 10, 2011. Archived from
1145:Radulovacki, Miodrag (March 2005).
353:, indicating the importance of the
337:Radulovacki spent 18 months at the
2190:American people of Serbian descent
1728:10.1111/j.1471-4159.1973.tb07549.x
138:Inventor of the Year Award, 2010,
14:
1511:Jouvet, Michel (March 22, 1993).
1221:University of Illinois at Chicago
471:. The explanation of adenosine's
291:Serbian town on the banks of the
1533:Baumann, Edward (July 4, 1987).
1089:10.1111/j.1532-5415.2008.02171.x
1056:10.1152/japplphysiol.00772.2005
568:Yugoslav Student Summer Program
322:Education and scientific career
116:Approaches in the Treatment of
2090:"Miodrag Radulovacki Obituary"
1463:. Elsevier. pp. 228–229.
283:In 1943, Radulovacki moved to
216:: Miodrag Radulovački), was a
1:
2205:Yugoslav expatriates in Sudan
1648:Radulovacki, Miodrag (1987).
1425:UCLA Brain Research Institute
1044:Journal of Applied Physiology
2155:People from Sremski Karlovci
1687:(11, number 11): 1289–1312.
1455:Adey, W. Ross (1967-01-01).
826:10.1016/0006-8993(81)90022-6
789:10.1016/0006-8993(80)91060-4
752:10.1016/0006-8993(77)90018-X
686:10.1016/0006-8993(73)90757-9
307:". Radulovacki graduated as
257:, a village in northwestern
452:effect on the responses of
261:. Both of his parents were
206:Miodrag (Misha) Radulovacki
2221:
2116:. Blic.rs. 6 February 2014
2032:Ecological Center Karlovci
1758:"Radulovacki Lab Research"
1716:Journal of Neurochemistry
550:Inventor of the Year 2010
199:
151:
25:
977:10.1378/chest.115.5.1397
147:, 2003, Belgrade, Serbia
2150:Scientists from Chicago
1166:10.1179/016164105X21814
905:10.1179/016164105X21814
411:Scientific achievements
349:is synchronous in both
343:electroencephalographic
212:: Миодраг Радуловачки;
100:, Serbia, (MD), (Ph.D.)
1787:(1, number 1): 35–41.
1616:10.1073/pnas.78.5.3260
1513:"From Amines to Sleep"
1010:10.1093/sleep/33.7.982
947:10.1093/sleep/21.2.131
723:10.1126/science.948760
574:University of Illinois
416:Adenosine Sleep Theory
399:Theory of Sleep, with
366:University of Khartoum
313:University of Belgrade
268:. At the beginning of
184:University of Khartoum
174:University of Belgrade
143:Foreign Member of the
98:University of Belgrade
1794:10.1093/sleep/30.1.35
1650:"Adenosine and sleep"
1154:Neurological Research
893:Neurological Research
666:Selected publications
650:Radulovacki lived in
639:geothermal heat pumps
357:in sleep regulation.
46:Kingdom of Yugoslavia
1656:. pp. 125–132.
1266:on October 21, 2013.
1036:Related publications
297:Karlovci High School
86:Karlovci High School
2094:legacy.suntimes.com
1607:1981PNAS...78.3260S
715:1976Sci...193.1025K
656:cross-country skier
606:Four Lions Fountain
374:cerebrospinal fluid
20:Miodrag Radulovacki
2185:Serbian scientists
2160:American inventors
2048:2012-04-26 at the
1997:2011-12-28 at the
1979:2012-04-26 at the
618:(Radichevich), at
458:neurophysiological
316:School of Medicine
195:(UIC), 1970 - 2014
111:Sleep Theory, 1984
2180:Serbian inventors
2175:Neuropharmacology
351:brain hemispheres
263:elementary school
203:
202:
163:Neuropharmacology
153:Scientific career
96:Medical Faculty,
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1601:(5): 3260–3264.
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1520:Current Contents
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1031:
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734:
709:(4257): 1025–7.
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616:Branko Radičević
598:Sremski Karlovci
578:Champaign-Urbana
285:Sremski Karlovci
218:Serbian American
210:Serbian Cyrillic
58:
30:
16:
2220:
2219:
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2213:
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2096:
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2083:
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2072:
2061:
2059:
2055:
2050:Wayback Machine
2041:
2037:
2030:
2026:
2019:
2015:
2008:
2004:
1999:Wayback Machine
1990:
1986:
1981:Wayback Machine
1972:
1968:
1954:
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1943:
1939:
1932:
1928:
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1540:Chicago Tribune
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1041:
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962:
927:
890:
878:(3–4): 327–39.
869:
848:
811:
774:
737:
700:
671:
668:
648:
626:(Frushka Gora)
590:
570:
561:
552:
485:
426:methylxanthines
418:
413:
332:Neurophysiology
324:
251:
191:
182:
177:
142:
125:
120:
114:Pharmacological
112:
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1835:
1828:
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1767:
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1568:(2): 268–274.
1546:
1525:
1503:
1476:
1469:
1447:
1444:on 2005-09-29.
1436:Hanley, John.
1428:
1417:
1403:
1387:
1367:
1341:
1315:
1294:
1269:
1251:
1248:on 2011-05-07.
1226:
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1137:
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493:Bioengineering
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320:
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247:
238:drug therapies
201:
200:
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171:
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155:
149:
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136:
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128:Basic Sciences
106:
105:Known for
102:
101:
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1492:(2): 255–65.
1491:
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610:
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446:iontophoretic
441:
439:
435:
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394:
393:Michel Jouvet
390:
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309:valedictorian
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274:Yugoslav Army
271:
267:
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246:
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239:
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219:
215:
214:Serbian Latin
211:
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38:28 April 1933
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2108:
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2016:
2005:
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1969:
1951:
1940:
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1918:
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1254:
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1241:
1211:
1200:
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743:
739:
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635:solar panels
595:
591:
588:Philanthropy
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505:experimental
486:
461:
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430:theophylline
419:
405:
359:
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325:
293:Danube River
282:
270:World War II
252:
222:Pharmacology
205:
204:
170:Institutions
152:
2145:2014 deaths
2140:1931 births
654:. He was a
624:Fruška Gora
497:sleep apnea
389:metabolites
234:sleep apnea
190:, 1967-1970
118:Sleep Apnea
74:Nationality
57:27 May 2014
2134:Categories
2120:2014-06-03
2099:2023-07-05
1663:9067640980
1115:References
620:Stražilovo
466:behavioral
450:depressant
434:micromolar
422:Sol Snyder
362:Physiology
249:Early life
660:Wisconsin
477:serotonin
438:receptors
401:serotonin
397:Monoamine
386:monoamine
355:brainstem
301:Cambridge
230:Adenosine
109:Adenosine
82:Education
2046:Archived
1995:Archived
1977:Archived
1959:Archived
1886:Archived
1868:Archived
1803:17310863
1744:46663273
1242:UIC News
1182:37526153
1174:15829175
1107:19220560
1064:16288102
1028:20614859
985:10334159
921:37526153
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768:39245160
582:Novi Sad
512:patented
489:Medicine
473:hypnotic
376:using a
266:teachers
176:, Serbia
122:Yugoslav
88:, Serbia
63:Belgrade
2067:YouTube
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711:Bibcode
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694:4705518
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380:to the
378:cannula
289:baroque
278:Germans
224:in the
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259:Serbia
255:Parage
159:Fields
135:Awards
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42:Parage
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1740:S2CID
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637:and
347:pons
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