Knowledge (XXG)

Monocarboxylate transporter 8

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Friesema EC, Grueters A, Biebermann H, Krude H, von Moers A, Reeser M, Barrett TG, Mancilla EE, Svensson J, Kester MH, Kuiper GG, Balkassmi S, Uitterlinden AG, Koehrle J, Rodien P, Halestrap AP, Visser TJ (2004). "Association between mutations in a thyroid hormone transporter and severe X-linked
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is about double its normal value). Normal looking at birth and for the first few years, hypotonic (floppy), in particular difficulty to hold the head, possibly difficulty to thrive, possibly with delayed myelination (if so, some cases are reported with an MRI pattern similar to
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A genetic disorder (discovered in 2003 and 2004) is caused by mutation in the transporter of thyroid hormone, MCT8, also known as SLC16A2, is believed to be account for a significant fraction of the undiagnosed neurological disorders (usually resulting in
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Vaurs-Barrière C, Deville M, Sarret C, Giraud G, Des Portes V, Prats-Viñas JM, De Michele G, Dan B, Brady AF, Boespflug-Tanguy O, Touraine R (Jan 2009). "Pelizaeus-Merzbacher-Like disease presentation of MCT8 mutated male subjects".
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Connors, Kristin A.; Korte, Joseph J.; Anderson, Grant W.; Degitz, Sigmund J. (2010-08-01). "Characterization of thyroid hormone transporter expression during tissue-specific metamorphic events in Xenopus tropicalis".
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Jansen J, Friesema EC, Kester MH, Milici C, Reeser M, GrĂĽters A, Barrett TG, Mancilla EE, Svensson J, Wemeau JL, Busi da Silva Canalli MH, Lundgren J, McEntagart ME, Hopper N, Arts WF, Visser TJ (Jun 2007).
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Friesema EC, Jansen J, Heuer H, Trajkovic M, Bauer K, Visser TJ (Sep 2006). "Mechanisms of disease: psychomotor retardation and high T3 levels caused by mutations in monocarboxylate transporter 8".
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Tsurusaki Y, Osaka H, Hamanoue H, Shimbo H, Tsuji M, Doi H, Saitsu H, Matsumoto N, Miyake N (Sep 2011). "Rapid detection of a mutation causing X-linked leucoencephalopathy by exome sequencing".
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level. Patients have an alert face, a limited IQ, patients may never talk/walk, 50% need feeding tube, patients have a normal life span. This disease can be ruled out with a simple TSH/T
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Debrand E, Heard E, Avner P (Mar 1998). "Cloning and localization of the murine Xpct gene: evidence for complex rearrangements during the evolution of the region around the Xist gene".
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Mughal, Bilal B.; Leemans, Michelle; Lima de Souza, Elaine C.; le Mevel, SĂ©bastien; Spirhanzlova, Petra; Visser, Theo J.; Fini, Jean-Baptiste; Demeneix, Barbara A. (2017-08-01).
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Schwartz CE, May MM, Carpenter NJ, Rogers RC, Martin J, Bialer MG, Ward J, Sanabria J, Marsa S, Lewis JA, Echeverri R, Lubs HA, Voeller K, Simensen RJ, Stevenson RE (Jul 2005).
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Brockmann K, Dumitrescu AM, Best TT, Hanefeld F, Refetoff S (Jun 2005). "X-linked paroxysmal dyskinesia and severe global retardation caused by defective MCT8 gene".
2354: 2192:"Functional analysis of monocarboxylate transporter 8 mutations identified in patients with X-linked psychomotor retardation and elevated serum triiodothyronine" 1888:"Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past" 5375: 3734: 696: 77: 677: 1701:
Halestrap AP, Meredith D (Feb 2004). "The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond".
4775: 1017: 3640: 2041:"The monocarboxylate transporter 8 linked to human psychomotor retardation is highly expressed in thyroid hormone-sensitive neuron populations" 5459: 5170: 4696: 1796: 1204: 1814:
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction".
1186: 5444: 5028: 2896: 2565: 2332: 1555:"Altered behavioral performance and live imaging of circuit-specific neural deficiencies in a zebrafish model for psychomotor retardation" 1504:"Altered behavioral performance and live imaging of circuit-specific neural deficiencies in a zebrafish model for psychomotor retardation" 4038: 3532: 2458: 2453: 2378: 2347: 241: 1960:"A novel syndrome combining thyroid and neurological abnormalities is associated with mutations in a monocarboxylate transporter gene" 1368:"A novel syndrome combining thyroid and neurological abnormalities is associated with mutations in a monocarboxylate transporter gene" 907: 900: 5424: 5325: 4492: 3454: 2752: 2666: 2423: 1046: 218: 3256: 1352: 3517: 2593: 2438: 1173: 1152: 5365: 2992: 5454: 5449: 5345: 5340: 5311: 3852: 3416: 3218: 3213: 2340: 2113:"Thyroid hormone transport by the human monocarboxylate transporter 8 and its rate-limiting role in intracellular metabolism" 1169: 1086:
zebrafish larvae exhibited neurological and behavioral deficiencies. They demonstrated reduced locomotor activity, altered
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Lafrenière RG, Carrel L, Willard HF (Jul 1994). "A novel transmembrane transporter encoded by the XPCT gene in Xq13.2".
57: 3327: 254: 153: 4307: 2295: 1025: 4186: 3890: 247: 146: 4259: 2762: 2371: 4916: 4572: 3065: 1843:
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997).
5320: 3208: 5104: 5370: 3192: 2959: 2290: 741: 65: 5061: 3588: 5330: 4962: 2691: 2316: 2276: 722: 5306: 5142: 4828: 4013: 3938: 3332: 3203: 3198: 2772: 2374: 1125: 2225: 5403: 5398: 3365: 2767: 1079: 129: 44: 1049:, known as PMD), possibly with decreased mitochondrial enzyme activities, possibly with fluctuating 4995: 2701: 2476: 1021: 862: 2757: 2271: 2177: 2099: 2027: 1763: 1726: 1484: 1440: 1112: 89: 48:, DXS128, DXS128E, MCT 7, MCT 8, MCT7, MCT8, MRX22, XPCT, AHDS, solute carrier family 16 member 2 883: 858: 832: 811: 492: 4898: 4893: 4241: 4236: 4163: 4158: 4153: 4148: 4143: 4138: 4118: 4113: 4108: 4103: 4088: 4078: 4068: 4063: 4053: 4028: 3834: 3819: 3814: 3436: 3431: 3426: 2213: 2169: 2134: 2091: 2062: 2019: 1989: 1946: 1917: 1874: 1831: 1802: 1792: 1755: 1718: 1679: 1671: 1635: 1627: 1586: 1535: 1476: 1432: 1397: 1334: 1285: 1239: 1020:(since 1944) without knowing its actual cause. It has been shown mutated in cases of X-linked 37: 5152: 5119: 5086: 5076: 5043: 5038: 4972: 4853: 4805: 4795: 4752: 4716: 4711: 4678: 4673: 4668: 4663: 4654: 4649: 4644: 4616: 4606: 4597: 4592: 4587: 4422: 4407: 4402: 4387: 4354: 4321: 4231: 4191: 3948: 3920: 3905: 3900: 3895: 3872: 3867: 3715: 3711: 3702: 3660: 3484: 3474: 3464: 3396: 3342: 3276: 3261: 3095: 3090: 3085: 2936: 2837: 2832: 2802: 2726: 2721: 2716: 2643: 1353:"Entrez Gene: SLC16A2 solute carrier family 16, member 2 (monocarboxylic acid transporter 8)" 85: 5198: 3299: 3037: 3027: 3012: 2974: 2969: 2787: 2711: 2638: 2363: 2203: 2159: 2124: 2083: 2052: 2011: 1979: 1971: 1938: 1907: 1899: 1864: 1856: 1823: 1784: 1747: 1710: 1663: 1617: 1576: 1566: 1525: 1515: 1468: 1424: 1387: 1379: 1324: 1316: 1275: 1231: 990: 334: 265: 209: 164: 1264:"Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter" 5282: 2367: 2256: 309: 2285: 2281: 1984: 1959: 1912: 1887: 1581: 1554: 1530: 1503: 1392: 1367: 1329: 1304: 1262:
Friesema EC, Ganguly S, Abdalla A, Manning Fox JE, Halestrap AP, Visser TJ (Oct 2003).
1106: 2015: 1869: 1844: 1606:"Functional Characterization of Xenopus Thyroid Hormone Transporters mct8 and oatp1c1" 611: 606: 601: 596: 580: 575: 570: 565: 549: 544: 539: 534: 5438: 5298: 1024:. Some of the symptoms for this disorder as are follows: normal to slightly elevated 521: 2103: 2031: 1767: 1730: 1488: 69: 2181: 2148:"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" 1444: 327: 106: 2039:
Heuer H, Maier MK, Iden S, Mittag J, Friesema EC, Visser TJ, Bauer K (Apr 2005).
1571: 1520: 1305:"Allan-Herndon-Dudley syndrome and the monocarboxylate transporter 8 (MCT8) gene" 93: 4921: 4377: 3973: 3174: 1667: 1209:
National Center for Biotechnology Information, U.S. National Library of Medicine
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National Center for Biotechnology Information, U.S. National Library of Medicine
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Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006).
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Zada D, Tovin A, Lerer-Goldshtein T, Vatine GD, Appelbaum L (Sep 2014).
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Zada D, Tovin A, Lerer-Goldshtein T, Vatine GD, Appelbaum L (Sep 2014).
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Dumitrescu AM, Liao XH, Best TB, Brockmann K, Refetoff S (Jan 2004).
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Dumitrescu AM, Liao XH, Best TB, Brockmann K, Refetoff S (Jan 2004).
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Friesema EC, Kuiper GG, Jansen J, Visser TJ, Kester MH (Nov 2006).
1975: 1383: 1320: 1082:-mediated targeted gene editing system. Similar to human patients, 3527: 3522: 2676: 2516: 2501: 2496: 2491: 2486: 2481: 626: 622: 5010: 5005: 5000: 2901: 974: 61: 5280: 5219: 4944: 4776:
System A & N, sodium-coupled neutral amino-acid transporter
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high affinity glutamate and neutral amino-acid transporter
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GrĂĽters A (2007). "Thyroid hormone transporter defects".
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cationic amino-acid transporter/glycoprotein-associated
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glycoprotein-associated/light or catalytic subunits of
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Nature Clinical Practice Endocrinology & Metabolism
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monocarboxylic acid transmembrane transporter activity
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Na-independent, system-L like amino-acid transporter
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The Journal of Clinical Endocrinology and Metabolism
5356: 5293: 5191: 5163: 5135: 5097: 5054: 5021: 4988: 4955: 4909: 4821: 4768: 4730: 4689: 4565: 4532: 4508: 4485: 4461: 4370: 4332: 4300: 4252: 4179: 3931: 3883: 3845: 3727: 3633: 3581: 3543: 3510: 3447: 3358: 3320: 3292: 3249: 3185: 3154: 3058: 2985: 2952: 2863: 2737: 2659: 2586: 2557: 2469: 2416: 2304: 2264: 876: 851: 825: 804: 1165: 1163: 1161: 1144: 1142: 1140: 550:thyroid hormone transmembrane transporter activity 264: 163: 1886:Price NT, Jackson VN, Halestrap AP (Jan 1998). 16:Protein-coding gene in the species Homo sapiens 1257: 1255: 1253: 1170:GRCm38: Ensembl release 89: ENSMUSG00000033965 2348: 2241: 8: 3735:organic cation/anion/zwitterion transporter 1845:"Large-scale concatenation cDNA sequencing" 1149:GRCh38: Ensembl release 89: ENSG00000147100 985:MCT8 actively transports a variety of iodo- 5290: 5277: 5216: 4952: 4941: 4458: 4447: 3630: 3619: 3257:human Na-sulfate/carboxylate cotransporter 3151: 3140: 2413: 2402: 2398: 2387: 2355: 2341: 2333: 2248: 2234: 2226: 637: 612:sodium-independent organic anion transport 517: 305: 204: 101: 2207: 2163: 2128: 2056: 1983: 1911: 1868: 1621: 1580: 1570: 1529: 1519: 1391: 1328: 1279: 3853:Na+-dependent ascorbic acid transporter 1136: 3641:Organic anion-transporting polypeptide 18: 4697:proton-coupled amino-acid transporter 2897:heterodimeric amino-acid transporters 2566:heterodimeric amino-acid transporters 1656:General and Comparative Endocrinology 1078:line was generated in 2014 using the 571:integral component of plasma membrane 269: 230: 225: 168: 127: 122: 7: 3162:proton coupled metal ion transporter 4738:sugar-phosphate/phosphate exchanger 4340:facilitative nucleoside transporter 2259:metabolism enzymes and transporters 1268:The Journal of Biological Chemistry 4540:type II Na-phosphate cotransporter 2753:sodium:neurotransmitter symporters 1964:American Journal of Human Genetics 1372:American Journal of Human Genetics 1309:American Journal of Human Genetics 873: 848: 822: 801: 777: 758: 732: 713: 687: 668: 487: 421:choroid plexus of fourth ventricle 405: 343: 322: 14: 4493:Vesicular glutamate transporter 1 3455:Vesicular glutamate transporter 1 3328:proton oligopeptide cotransporter 970:that in humans is encoded by the 491: 253: 246: 240: 217: 152: 145: 139: 114: 4308:Na-coupled nucleoside transport 4187:multifunctional anion exchanger 3518:vesicular monoamine transporter 989:including the thyroid hormones 566:integral component of membrane 502:More reference expression data 471:More reference expression data 1: 5171:multidrug and toxin extrusion 4260:fatty acid transport proteins 2477:facilitative GLUT transporter 2312:Monocarboxylate transporter 8 2016:10.1016/S0140-6736(04)17226-7 1018:Allan–Herndon–Dudley syndrome 960:Monocarboxylate transporter 8 597:monocarboxylic acid transport 238: 137: 5460:Thyroid hormone transporters 4917:basolateral iron transporter 4573:nucleoside-sugar transporter 3066:sodium bile salt cotransport 2667:sodium glucose cotransporter 1572:10.1371/journal.pgen.1004615 1521:10.1371/journal.pgen.1004615 1047:Pelizaeus–Merzbacher disease 425:Epithelium of choroid plexus 5445:Genes on human chromosome X 2372:membrane transport proteins 2296:Diiodotyrosine transaminase 1668:10.1016/j.ygcen.2010.04.015 1417:Journal of Medical Genetics 966:) is an active transporter 391:stromal cell of endometrium 5476: 5105:Putative sugar transporter 2165:10.1016/j.cell.2006.09.026 2002:psychomotor retardation". 1104:has been characterised in 1080:zinc-finger nuclease (ZFN) 5420: 5289: 5276: 5226: 5215: 4951: 4940: 4457: 4446: 3629: 3618: 3150: 3139: 2412: 2401: 2397: 2386: 2088:10.1007/s00415-005-0713-3 1715:10.1007/s00424-003-1067-2 1205:"Mouse PubMed Reference:" 1187:"Human PubMed Reference:" 946: 941: 937: 930: 914: 908:Chr X: 102.74 – 102.87 Mb 895: 880: 855: 844: 829: 808: 797: 784: 780: 765: 761: 752: 739: 735: 720: 716: 707: 694: 690: 675: 671: 662: 647: 640: 636: 620: 602:thyroid hormone transport 520: 516: 499: 490: 481: 468: 417: 408: 355: 346: 316: 308: 304: 287: 274: 237: 216: 207: 203: 186: 173: 136: 113: 104: 100: 55: 52: 42: 35: 30: 26: 21: 5425:solute carrier disorders 5062:Choline-like transporter 3193:electroneutral cation-Cl 2291:Iodothyronine deiodinase 1224:Human Molecular Genetics 4963:Magnesium transporter E 2594:bicarbonate transporter 2317:Sodium-iodide symporter 2277:Iodotyrosine deiodinase 2117:Molecular Endocrinology 1892:The Biochemical Journal 1816:Analytical Biochemistry 1429:10.1136/jmg.2010.083535 901:Chr X: 74.42 – 74.53 Mb 607:transmembrane transport 449:internal carotid artery 5358:Antiporter (exchanger) 1943:10.1006/geno.1997.5173 1828:10.1006/abio.1996.0138 1281:10.1074/jbc.M300909200 5455:Genes mutated in mice 5450:Solute carrier family 4829:metal ion transporter 3939:mitochondrial carrier 3589:type III Na-phosphate 1777:Endocrine Development 1752:10.1038/ncpendmet0262 1623:10.1210/en.2017-00108 1126:Solute carrier family 1007:Clinical significance 2209:10.1210/jc.2006-2570 2130:10.1210/me.2005-0256 2076:Journal of Neurology 2058:10.1210/en.2004-1179 1236:10.1093/hmg/3.7.1133 545:transporter activity 363:right adrenal cortex 232:X chromosome (mouse) 130:X chromosome (human) 4996:Ammonia transporter 3891:Na/(Ca-K) exchanger 1461:Annals of Neurology 1022:leukoencephalopathy 379:ganglionic eminence 375:left adrenal cortex 367:right lobe of liver 359:right adrenal gland 271:X D|X 46.29 cM 94:SLC16A2 - orthologs 5143:Folate transporter 2564:heavy subunits of 2272:Thyroid peroxidase 1861:10.1101/gr.7.4.353 1113:Xenopus tropicalis 742:ENSMUSG00000033965 590:Biological process 559:Cellular component 535:symporter activity 528:Molecular function 429:left lobe of liver 387:anterior pituitary 371:left adrenal gland 5432: 5431: 5416: 5415: 5412: 5411: 5272: 5271: 5268: 5267: 5264: 5263: 5211: 5210: 5207: 5206: 4936: 4935: 4932: 4931: 4442: 4441: 4438: 4437: 3614: 3613: 3610: 3609: 3135: 3134: 3131: 3130: 2364:Membrane proteins 2330: 2329: 1904:10.1042/bj3290321 1798:978-3-8055-8296-4 1789:10.1159/000106823 1473:10.1002/ana.21579 957: 956: 953: 952: 926: 925: 891: 890: 870: 869: 840: 839: 819: 818: 793: 792: 774: 773: 748: 747: 729: 728: 703: 702: 684: 683: 632: 631: 512: 511: 508: 507: 477: 476: 464: 463: 402: 401: 300: 299: 199: 198: 5467: 5391: 5390: 5389: 5291: 5278: 5217: 5199:Heme transporter 4953: 4942: 4459: 4448: 3631: 3620: 3300:urea transporter 3152: 3141: 2414: 2403: 2399: 2388: 2368:carrier proteins 2357: 2350: 2343: 2334: 2250: 2243: 2236: 2227: 2221: 2211: 2185: 2167: 2142: 2132: 2107: 2070: 2060: 2035: 2010:(9443): 1435–7. 1997: 1987: 1954: 1925: 1915: 1882: 1872: 1839: 1810: 1771: 1734: 1688: 1687: 1650: 1644: 1643: 1625: 1616:(8): 2694–2705. 1601: 1595: 1594: 1584: 1574: 1550: 1544: 1543: 1533: 1523: 1499: 1493: 1492: 1455: 1449: 1448: 1412: 1406: 1405: 1395: 1363: 1357: 1356: 1349: 1343: 1342: 1332: 1300: 1294: 1293: 1283: 1274:(41): 40128–35. 1259: 1248: 1247: 1219: 1213: 1212: 1201: 1195: 1194: 1183: 1177: 1167: 1156: 1146: 939: 938: 910: 903: 886: 874: 865: 849: 845:RefSeq (protein) 835: 823: 814: 802: 778: 759: 733: 714: 688: 669: 638: 518: 504: 495: 488: 473: 457:genital tubercle 413: 411:Top expressed in 406: 383:ventricular zone 351: 349:Top expressed in 344: 323: 306: 296: 283: 272: 257: 250: 244: 233: 221: 205: 195: 182: 171: 156: 149: 143: 132: 118: 102: 96: 47: 40: 19: 5475: 5474: 5470: 5469: 5468: 5466: 5465: 5464: 5435: 5434: 5433: 5428: 5408: 5388: 5385: 5384: 5383: 5381: 5352: 5315: 5285: 5260: 5222: 5203: 5187: 5159: 5131: 5093: 5050: 5017: 4984: 4947: 4928: 4905: 4817: 4764: 4726: 4685: 4561: 4528: 4504: 4481: 4453: 4434: 4366: 4328: 4296: 4248: 4175: 3927: 3879: 3841: 3723: 3625: 3606: 3577: 3539: 3506: 3443: 3366:monocarboxylate 3354: 3316: 3288: 3245: 3181: 3146: 3127: 3054: 2981: 2960:Na/Ca exchanger 2948: 2859: 2733: 2655: 2582: 2553: 2465: 2408: 2393: 2382: 2361: 2331: 2326: 2300: 2260: 2257:Thyroid hormone 2254: 2224: 2188: 2145: 2123:(11): 2761–72. 2110: 2073: 2038: 2000: 1957: 1928: 1885: 1849:Genome Research 1842: 1813: 1799: 1774: 1737: 1703:PflĂĽgers Archiv 1700: 1696: 1694:Further reading 1691: 1652: 1651: 1647: 1603: 1602: 1598: 1565:(9): e1004615. 1552: 1551: 1547: 1514:(9): e1004615. 1501: 1500: 1496: 1457: 1456: 1452: 1414: 1413: 1409: 1365: 1364: 1360: 1351: 1350: 1346: 1302: 1301: 1297: 1261: 1260: 1251: 1221: 1220: 1216: 1203: 1202: 1198: 1185: 1184: 1180: 1168: 1159: 1147: 1138: 1134: 1122: 1098: 1072: 1067: 1065:Model organisms 1060: 1056: 1043: 1039: 1035: 1031: 1009: 1001: 994: 983: 948:View/Edit Mouse 943:View/Edit Human 906: 899: 896:Location (UCSC) 882: 861: 857: 831: 810: 723:ENSG00000147100 616: 585: 581:plasma membrane 554: 500: 469: 460: 455: 453:proximal tubule 451: 447: 443: 439: 435: 431: 427: 423: 409: 398: 393: 389: 385: 381: 377: 373: 369: 365: 361: 347: 291: 278: 270: 260: 259: 258: 251: 231: 208:Gene location ( 190: 177: 169: 159: 158: 157: 150: 128: 105:Gene location ( 56: 43: 36: 17: 12: 11: 5: 5473: 5471: 5463: 5462: 5457: 5452: 5447: 5437: 5436: 5430: 5429: 5421: 5418: 5417: 5414: 5413: 5410: 5409: 5407: 5406: 5401: 5396: 5395: 5394: 5386: 5368: 5362: 5360: 5354: 5353: 5351: 5350: 5349: 5348: 5343: 5333: 5328: 5323: 5318: 5313: 5309: 5303: 5301: 5287: 5286: 5281: 5274: 5273: 5270: 5269: 5266: 5265: 5262: 5261: 5259: 5258: 5253: 5248: 5243: 5238: 5233: 5227: 5224: 5223: 5220: 5213: 5212: 5209: 5208: 5205: 5204: 5202: 5201: 5195: 5193: 5189: 5188: 5186: 5185: 5184: 5183: 5178: 5167: 5165: 5161: 5160: 5158: 5157: 5156: 5155: 5150: 5139: 5137: 5133: 5132: 5130: 5129: 5128: 5127: 5122: 5117: 5112: 5101: 5099: 5095: 5094: 5092: 5091: 5090: 5089: 5084: 5079: 5074: 5069: 5058: 5056: 5052: 5051: 5049: 5048: 5047: 5046: 5041: 5036: 5025: 5023: 5019: 5018: 5016: 5015: 5014: 5013: 5008: 5003: 4992: 4990: 4986: 4985: 4983: 4982: 4981: 4980: 4975: 4970: 4959: 4957: 4949: 4948: 4945: 4938: 4937: 4934: 4933: 4930: 4929: 4927: 4926: 4925: 4924: 4913: 4911: 4907: 4906: 4904: 4903: 4902: 4901: 4896: 4891: 4886: 4881: 4876: 4871: 4866: 4861: 4856: 4851: 4846: 4841: 4836: 4825: 4823: 4819: 4818: 4816: 4815: 4814: 4813: 4808: 4803: 4798: 4793: 4788: 4783: 4772: 4770: 4766: 4765: 4763: 4762: 4761: 4760: 4755: 4750: 4745: 4734: 4732: 4728: 4727: 4725: 4724: 4723: 4722: 4714: 4709: 4704: 4693: 4691: 4687: 4686: 4684: 4683: 4682: 4681: 4676: 4671: 4666: 4659: 4658: 4657: 4652: 4647: 4640: 4639: 4638: 4633: 4626: 4625: 4624: 4619: 4614: 4609: 4602: 4601: 4600: 4595: 4590: 4585: 4580: 4569: 4567: 4563: 4562: 4560: 4559: 4558: 4557: 4552: 4547: 4536: 4534: 4530: 4529: 4527: 4526: 4525: 4524: 4512: 4510: 4506: 4505: 4503: 4502: 4501: 4500: 4489: 4487: 4483: 4482: 4480: 4479: 4478: 4477: 4465: 4463: 4455: 4454: 4451: 4444: 4443: 4440: 4439: 4436: 4435: 4433: 4432: 4431: 4430: 4425: 4420: 4415: 4410: 4405: 4400: 4395: 4390: 4385: 4374: 4372: 4368: 4367: 4365: 4364: 4363: 4362: 4357: 4352: 4347: 4336: 4334: 4330: 4329: 4327: 4326: 4325: 4324: 4319: 4304: 4302: 4298: 4297: 4295: 4294: 4293: 4292: 4287: 4282: 4277: 4272: 4267: 4256: 4254: 4250: 4249: 4247: 4246: 4245: 4244: 4239: 4234: 4229: 4224: 4219: 4214: 4209: 4204: 4199: 4194: 4183: 4181: 4177: 4176: 4174: 4173: 4172: 4171: 4166: 4161: 4156: 4151: 4146: 4141: 4136: 4131: 4126: 4121: 4116: 4111: 4106: 4101: 4096: 4091: 4086: 4081: 4076: 4071: 4066: 4061: 4056: 4051: 4046: 4041: 4036: 4031: 4026: 4021: 4016: 4011: 4006: 4001: 3996: 3991: 3986: 3981: 3976: 3971: 3966: 3961: 3956: 3951: 3946: 3935: 3933: 3929: 3928: 3926: 3925: 3924: 3923: 3918: 3913: 3908: 3903: 3898: 3887: 3885: 3881: 3880: 3878: 3877: 3876: 3875: 3870: 3865: 3860: 3849: 3847: 3843: 3842: 3840: 3839: 3838: 3837: 3832: 3827: 3822: 3817: 3812: 3807: 3802: 3797: 3792: 3787: 3782: 3777: 3772: 3767: 3762: 3757: 3752: 3747: 3742: 3731: 3729: 3725: 3724: 3722: 3721: 3720: 3719: 3707: 3706: 3705: 3700: 3693: 3692: 3691: 3684: 3683: 3682: 3677: 3670: 3669: 3668: 3663: 3658: 3653: 3648: 3637: 3635: 3627: 3626: 3623: 3616: 3615: 3612: 3611: 3608: 3607: 3605: 3604: 3603: 3602: 3597: 3591:cotransporter 3585: 3583: 3579: 3578: 3576: 3575: 3574: 3573: 3568: 3563: 3547: 3545: 3541: 3540: 3538: 3537: 3536: 3535: 3530: 3525: 3514: 3512: 3508: 3507: 3505: 3504: 3503: 3502: 3497: 3492: 3487: 3482: 3477: 3472: 3467: 3462: 3451: 3449: 3445: 3444: 3442: 3441: 3440: 3439: 3434: 3429: 3424: 3419: 3414: 3409: 3404: 3399: 3394: 3389: 3384: 3379: 3374: 3362: 3360: 3356: 3355: 3353: 3352: 3351: 3350: 3345: 3340: 3335: 3324: 3322: 3318: 3317: 3315: 3314: 3313: 3312: 3307: 3296: 3294: 3290: 3289: 3287: 3286: 3285: 3284: 3279: 3274: 3269: 3264: 3253: 3251: 3247: 3246: 3244: 3243: 3242: 3241: 3236: 3231: 3226: 3221: 3216: 3211: 3206: 3201: 3195:cotransporter 3189: 3187: 3183: 3182: 3180: 3179: 3178: 3177: 3169: 3158: 3156: 3148: 3147: 3144: 3137: 3136: 3133: 3132: 3129: 3128: 3126: 3125: 3120: 3115: 3110: 3105: 3104: 3103: 3098: 3093: 3088: 3083: 3078: 3073: 3062: 3060: 3056: 3055: 3053: 3052: 3051: 3050: 3045: 3040: 3035: 3030: 3025: 3020: 3015: 3010: 3005: 3000: 2993:Na/H exchanger 2989: 2987: 2983: 2982: 2980: 2979: 2978: 2977: 2972: 2967: 2956: 2954: 2950: 2949: 2947: 2946: 2945: 2944: 2939: 2934: 2929: 2924: 2919: 2914: 2909: 2904: 2893: 2892: 2891: 2886: 2881: 2876: 2867: 2865: 2861: 2860: 2858: 2857: 2856: 2855: 2850: 2845: 2840: 2835: 2830: 2825: 2820: 2815: 2810: 2805: 2800: 2795: 2790: 2785: 2780: 2775: 2770: 2765: 2760: 2741: 2739: 2735: 2734: 2732: 2731: 2730: 2729: 2724: 2719: 2714: 2709: 2704: 2699: 2694: 2689: 2684: 2679: 2674: 2663: 2661: 2657: 2656: 2654: 2653: 2652: 2651: 2646: 2641: 2636: 2631: 2626: 2621: 2616: 2611: 2606: 2601: 2590: 2588: 2584: 2583: 2581: 2580: 2579: 2578: 2573: 2561: 2559: 2555: 2554: 2552: 2551: 2550: 2549: 2544: 2539: 2534: 2529: 2524: 2519: 2514: 2509: 2504: 2499: 2494: 2489: 2484: 2473: 2471: 2467: 2466: 2464: 2463: 2462: 2461: 2456: 2451: 2446: 2441: 2436: 2431: 2420: 2418: 2410: 2409: 2406: 2395: 2394: 2391: 2384: 2383: 2375:solute carrier 2362: 2360: 2359: 2352: 2345: 2337: 2328: 2327: 2325: 2324: 2319: 2314: 2308: 2306: 2302: 2301: 2299: 2298: 2293: 2288: 2286:Dual oxidase 2 2282:Dual oxidase 1 2279: 2274: 2268: 2266: 2262: 2261: 2255: 2253: 2252: 2245: 2238: 2230: 2223: 2222: 2202:(6): 2378–81. 2186: 2143: 2108: 2071: 2036: 1998: 1976:10.1086/380999 1955: 1937:(3): 296–303. 1926: 1883: 1840: 1811: 1797: 1772: 1735: 1697: 1695: 1692: 1690: 1689: 1662:(1): 149–159. 1645: 1596: 1545: 1494: 1450: 1407: 1384:10.1086/380999 1358: 1344: 1321:10.1086/431313 1295: 1249: 1214: 1196: 1178: 1157: 1135: 1133: 1130: 1129: 1128: 1121: 1118: 1107:Xenopus laevis 1100:Expression of 1097: 1092: 1071: 1068: 1066: 1063: 1061:thyroid test. 1058: 1054: 1041: 1037: 1033: 1029: 1008: 1005: 999: 992: 982: 979: 955: 954: 951: 950: 945: 935: 934: 928: 927: 924: 923: 921: 919: 912: 911: 904: 897: 893: 892: 889: 888: 878: 877: 871: 868: 867: 853: 852: 846: 842: 841: 838: 837: 827: 826: 820: 817: 816: 806: 805: 799: 795: 794: 791: 790: 782: 781: 775: 772: 771: 763: 762: 756: 750: 749: 746: 745: 737: 736: 730: 727: 726: 718: 717: 711: 705: 704: 701: 700: 692: 691: 685: 682: 681: 673: 672: 666: 660: 659: 654: 649: 645: 644: 634: 633: 630: 629: 618: 617: 615: 614: 609: 604: 599: 593: 591: 587: 586: 584: 583: 578: 573: 568: 562: 560: 556: 555: 553: 552: 547: 542: 537: 531: 529: 525: 524: 514: 513: 510: 509: 506: 505: 497: 496: 485: 479: 478: 475: 474: 466: 465: 462: 461: 459: 458: 454: 450: 446: 442: 438: 437:tail of embryo 434: 430: 426: 422: 418: 415: 414: 403: 400: 399: 397: 396: 392: 388: 384: 380: 376: 372: 368: 364: 360: 356: 353: 352: 340: 339: 331: 320: 314: 313: 310:RNA expression 302: 301: 298: 297: 289: 285: 284: 276: 273: 268: 262: 261: 252: 245: 239: 235: 234: 229: 223: 222: 214: 213: 201: 200: 197: 196: 188: 184: 183: 175: 172: 167: 161: 160: 151: 144: 138: 134: 133: 126: 120: 119: 111: 110: 98: 97: 54: 50: 49: 41: 33: 32: 28: 27: 24: 23: 15: 13: 10: 9: 6: 4: 3: 2: 5472: 5461: 5458: 5456: 5453: 5451: 5448: 5446: 5443: 5442: 5440: 5427: 5426: 5419: 5405: 5402: 5400: 5397: 5393: 5377: 5374: 5373: 5372: 5369: 5367: 5364: 5363: 5361: 5359: 5355: 5347: 5344: 5342: 5339: 5338: 5337: 5334: 5332: 5329: 5327: 5324: 5322: 5319: 5317: 5310: 5308: 5305: 5304: 5302: 5300: 5299:Cotransporter 5296: 5292: 5288: 5284: 5279: 5275: 5257: 5254: 5252: 5249: 5247: 5244: 5242: 5239: 5237: 5234: 5232: 5229: 5228: 5225: 5218: 5214: 5200: 5197: 5196: 5194: 5190: 5182: 5179: 5177: 5174: 5173: 5172: 5169: 5168: 5166: 5162: 5154: 5151: 5149: 5146: 5145: 5144: 5141: 5140: 5138: 5134: 5126: 5123: 5121: 5118: 5116: 5113: 5111: 5108: 5107: 5106: 5103: 5102: 5100: 5096: 5088: 5085: 5083: 5080: 5078: 5075: 5073: 5070: 5068: 5065: 5064: 5063: 5060: 5059: 5057: 5053: 5045: 5042: 5040: 5037: 5035: 5032: 5031: 5030: 5027: 5026: 5024: 5020: 5012: 5009: 5007: 5004: 5002: 4999: 4998: 4997: 4994: 4993: 4991: 4987: 4979: 4976: 4974: 4971: 4969: 4966: 4965: 4964: 4961: 4960: 4958: 4954: 4950: 4943: 4939: 4923: 4920: 4919: 4918: 4915: 4914: 4912: 4908: 4900: 4897: 4895: 4892: 4890: 4887: 4885: 4882: 4880: 4877: 4875: 4872: 4870: 4867: 4865: 4862: 4860: 4857: 4855: 4852: 4850: 4847: 4845: 4842: 4840: 4837: 4835: 4832: 4831: 4830: 4827: 4826: 4824: 4820: 4812: 4809: 4807: 4804: 4802: 4799: 4797: 4794: 4792: 4789: 4787: 4784: 4782: 4779: 4778: 4777: 4774: 4773: 4771: 4767: 4759: 4756: 4754: 4751: 4749: 4746: 4744: 4741: 4740: 4739: 4736: 4735: 4733: 4729: 4721: 4718: 4715: 4713: 4710: 4708: 4705: 4703: 4700: 4699: 4698: 4695: 4694: 4692: 4688: 4680: 4677: 4675: 4672: 4670: 4667: 4665: 4662: 4661: 4660: 4656: 4653: 4651: 4648: 4646: 4643: 4642: 4641: 4637: 4634: 4632: 4629: 4628: 4627: 4623: 4620: 4618: 4615: 4613: 4610: 4608: 4605: 4604: 4603: 4599: 4596: 4594: 4591: 4589: 4586: 4584: 4581: 4579: 4576: 4575: 4574: 4571: 4570: 4568: 4564: 4556: 4553: 4551: 4548: 4546: 4543: 4542: 4541: 4538: 4537: 4535: 4531: 4523: 4520: 4519: 4517: 4514: 4513: 4511: 4507: 4499: 4496: 4495: 4494: 4491: 4490: 4488: 4484: 4476: 4473: 4472: 4470: 4467: 4466: 4464: 4460: 4456: 4449: 4445: 4429: 4426: 4424: 4421: 4419: 4416: 4414: 4411: 4409: 4406: 4404: 4401: 4399: 4396: 4394: 4391: 4389: 4386: 4384: 4381: 4380: 4379: 4376: 4375: 4373: 4369: 4361: 4358: 4356: 4353: 4351: 4348: 4346: 4343: 4342: 4341: 4338: 4337: 4335: 4331: 4323: 4320: 4318: 4315: 4314: 4313: 4309: 4306: 4305: 4303: 4299: 4291: 4288: 4286: 4283: 4281: 4278: 4276: 4273: 4271: 4268: 4266: 4263: 4262: 4261: 4258: 4257: 4255: 4251: 4243: 4240: 4238: 4235: 4233: 4230: 4228: 4225: 4223: 4220: 4218: 4215: 4213: 4210: 4208: 4205: 4203: 4200: 4198: 4195: 4193: 4190: 4189: 4188: 4185: 4184: 4182: 4178: 4170: 4167: 4165: 4162: 4160: 4157: 4155: 4152: 4150: 4147: 4145: 4142: 4140: 4137: 4135: 4132: 4130: 4127: 4125: 4122: 4120: 4117: 4115: 4112: 4110: 4107: 4105: 4102: 4100: 4097: 4095: 4092: 4090: 4087: 4085: 4082: 4080: 4077: 4075: 4072: 4070: 4067: 4065: 4062: 4060: 4057: 4055: 4052: 4050: 4047: 4045: 4042: 4040: 4037: 4035: 4032: 4030: 4027: 4025: 4022: 4020: 4017: 4015: 4012: 4010: 4007: 4005: 4002: 4000: 3997: 3995: 3992: 3990: 3987: 3985: 3982: 3980: 3977: 3975: 3972: 3970: 3967: 3965: 3962: 3960: 3957: 3955: 3952: 3950: 3947: 3945: 3942: 3941: 3940: 3937: 3936: 3934: 3930: 3922: 3919: 3917: 3914: 3912: 3909: 3907: 3904: 3902: 3899: 3897: 3894: 3893: 3892: 3889: 3888: 3886: 3882: 3874: 3871: 3869: 3866: 3864: 3861: 3859: 3856: 3855: 3854: 3851: 3850: 3848: 3844: 3836: 3833: 3831: 3828: 3826: 3823: 3821: 3818: 3816: 3813: 3811: 3808: 3806: 3803: 3801: 3798: 3796: 3793: 3791: 3788: 3786: 3783: 3781: 3778: 3776: 3773: 3771: 3768: 3766: 3763: 3761: 3758: 3756: 3753: 3751: 3748: 3746: 3743: 3741: 3738: 3737: 3736: 3733: 3732: 3730: 3726: 3717: 3713: 3710: 3709: 3708: 3704: 3701: 3699: 3696: 3695: 3694: 3690: 3687: 3686: 3685: 3681: 3678: 3676: 3673: 3672: 3671: 3667: 3664: 3662: 3659: 3657: 3654: 3652: 3649: 3647: 3644: 3643: 3642: 3639: 3638: 3636: 3632: 3628: 3621: 3617: 3601: 3598: 3596: 3593: 3592: 3590: 3587: 3586: 3584: 3580: 3572: 3569: 3567: 3564: 3562: 3559: 3558: 3556: 3552: 3549: 3548: 3546: 3542: 3534: 3531: 3529: 3526: 3524: 3521: 3520: 3519: 3516: 3515: 3513: 3509: 3501: 3498: 3496: 3493: 3491: 3488: 3486: 3483: 3481: 3478: 3476: 3473: 3471: 3468: 3466: 3463: 3461: 3458: 3457: 3456: 3453: 3452: 3450: 3446: 3438: 3435: 3433: 3430: 3428: 3425: 3423: 3420: 3418: 3415: 3413: 3410: 3408: 3405: 3403: 3400: 3398: 3395: 3393: 3390: 3388: 3385: 3383: 3380: 3378: 3375: 3373: 3370: 3369: 3367: 3364: 3363: 3361: 3357: 3349: 3346: 3344: 3341: 3339: 3336: 3334: 3331: 3330: 3329: 3326: 3325: 3323: 3319: 3311: 3308: 3306: 3303: 3302: 3301: 3298: 3297: 3295: 3291: 3283: 3280: 3278: 3275: 3273: 3270: 3268: 3265: 3263: 3260: 3259: 3258: 3255: 3254: 3252: 3248: 3240: 3237: 3235: 3232: 3230: 3227: 3225: 3222: 3220: 3217: 3215: 3212: 3210: 3207: 3205: 3202: 3200: 3197: 3196: 3194: 3191: 3190: 3188: 3184: 3176: 3173: 3170: 3168: 3165: 3164: 3163: 3160: 3159: 3157: 3153: 3149: 3142: 3138: 3124: 3121: 3119: 3116: 3114: 3111: 3109: 3106: 3102: 3099: 3097: 3094: 3092: 3089: 3087: 3084: 3082: 3079: 3077: 3074: 3072: 3069: 3068: 3067: 3064: 3063: 3061: 3057: 3049: 3046: 3044: 3041: 3039: 3036: 3034: 3031: 3029: 3026: 3024: 3021: 3019: 3016: 3014: 3011: 3009: 3006: 3004: 3001: 2999: 2996: 2995: 2994: 2991: 2990: 2988: 2984: 2976: 2973: 2971: 2968: 2966: 2963: 2962: 2961: 2958: 2957: 2955: 2951: 2943: 2940: 2938: 2935: 2933: 2930: 2928: 2925: 2923: 2920: 2918: 2915: 2913: 2910: 2908: 2905: 2903: 2900: 2899: 2898: 2894: 2890: 2887: 2885: 2882: 2880: 2877: 2875: 2872: 2871: 2869: 2868: 2866: 2862: 2854: 2851: 2849: 2846: 2844: 2841: 2839: 2836: 2834: 2831: 2829: 2826: 2824: 2821: 2819: 2816: 2814: 2811: 2809: 2806: 2804: 2801: 2799: 2796: 2794: 2791: 2789: 2786: 2784: 2781: 2779: 2776: 2774: 2771: 2769: 2766: 2764: 2761: 2759: 2756: 2755: 2754: 2750: 2746: 2743: 2742: 2740: 2736: 2728: 2725: 2723: 2720: 2718: 2715: 2713: 2710: 2708: 2705: 2703: 2700: 2698: 2695: 2693: 2690: 2688: 2685: 2683: 2680: 2678: 2675: 2673: 2670: 2669: 2668: 2665: 2664: 2662: 2658: 2650: 2647: 2645: 2642: 2640: 2637: 2635: 2632: 2630: 2627: 2625: 2622: 2620: 2617: 2615: 2612: 2610: 2607: 2605: 2602: 2600: 2597: 2596: 2595: 2592: 2591: 2589: 2585: 2577: 2574: 2572: 2569: 2568: 2567: 2563: 2562: 2560: 2556: 2548: 2545: 2543: 2540: 2538: 2535: 2533: 2530: 2528: 2525: 2523: 2520: 2518: 2515: 2513: 2510: 2508: 2505: 2503: 2500: 2498: 2495: 2493: 2490: 2488: 2485: 2483: 2480: 2479: 2478: 2475: 2474: 2472: 2468: 2460: 2457: 2455: 2452: 2450: 2447: 2445: 2442: 2440: 2437: 2435: 2432: 2430: 2427: 2426: 2425: 2422: 2421: 2419: 2415: 2411: 2404: 2400: 2396: 2389: 2385: 2380: 2376: 2373: 2369: 2365: 2358: 2353: 2351: 2346: 2344: 2339: 2338: 2335: 2323: 2320: 2318: 2315: 2313: 2310: 2309: 2307: 2303: 2297: 2294: 2292: 2289: 2287: 2283: 2280: 2278: 2275: 2273: 2270: 2269: 2267: 2263: 2258: 2251: 2246: 2244: 2239: 2237: 2232: 2231: 2228: 2219: 2215: 2210: 2205: 2201: 2197: 2193: 2187: 2183: 2179: 2175: 2171: 2166: 2161: 2158:(3): 635–48. 2157: 2153: 2149: 2144: 2140: 2136: 2131: 2126: 2122: 2118: 2114: 2109: 2105: 2101: 2097: 2093: 2089: 2085: 2081: 2077: 2072: 2068: 2064: 2059: 2054: 2051:(4): 1701–6. 2050: 2046: 2045:Endocrinology 2042: 2037: 2033: 2029: 2025: 2021: 2017: 2013: 2009: 2005: 1999: 1995: 1991: 1986: 1981: 1977: 1973: 1970:(1): 168–75. 1969: 1965: 1961: 1956: 1952: 1948: 1944: 1940: 1936: 1932: 1927: 1923: 1919: 1914: 1909: 1905: 1901: 1897: 1893: 1889: 1884: 1880: 1876: 1871: 1866: 1862: 1858: 1854: 1850: 1846: 1841: 1837: 1833: 1829: 1825: 1822:(1): 107–13. 1821: 1817: 1812: 1808: 1804: 1800: 1794: 1790: 1786: 1782: 1778: 1773: 1769: 1765: 1761: 1757: 1753: 1749: 1746:(9): 512–23. 1745: 1741: 1736: 1732: 1728: 1724: 1720: 1716: 1712: 1709:(5): 619–28. 1708: 1704: 1699: 1698: 1693: 1685: 1681: 1677: 1673: 1669: 1665: 1661: 1657: 1649: 1646: 1641: 1637: 1633: 1629: 1624: 1619: 1615: 1611: 1610:Endocrinology 1607: 1600: 1597: 1592: 1588: 1583: 1578: 1573: 1568: 1564: 1560: 1559:PLOS Genetics 1556: 1549: 1546: 1541: 1537: 1532: 1527: 1522: 1517: 1513: 1509: 1508:PLOS Genetics 1505: 1498: 1495: 1490: 1486: 1482: 1478: 1474: 1470: 1466: 1462: 1454: 1451: 1446: 1442: 1438: 1434: 1430: 1426: 1422: 1418: 1411: 1408: 1403: 1399: 1394: 1389: 1385: 1381: 1378:(1): 168–75. 1377: 1373: 1369: 1362: 1359: 1354: 1348: 1345: 1340: 1336: 1331: 1326: 1322: 1318: 1314: 1310: 1306: 1299: 1296: 1291: 1287: 1282: 1277: 1273: 1269: 1265: 1258: 1256: 1254: 1250: 1245: 1241: 1237: 1233: 1230:(7): 1133–9. 1229: 1225: 1218: 1215: 1210: 1206: 1200: 1197: 1192: 1188: 1182: 1179: 1175: 1171: 1166: 1164: 1162: 1158: 1154: 1150: 1145: 1143: 1141: 1137: 1131: 1127: 1124: 1123: 1119: 1117: 1115: 1114: 1109: 1108: 1103: 1096: 1093: 1091: 1089: 1085: 1081: 1077: 1069: 1064: 1062: 1052: 1048: 1032:and reduced T 1027: 1023: 1019: 1015: 1006: 1004: 1002: 995: 988: 980: 978: 976: 973: 969: 965: 961: 949: 944: 940: 936: 933: 929: 922: 920: 917: 913: 909: 905: 902: 898: 894: 887: 885: 879: 875: 872: 866: 864: 860: 854: 850: 847: 843: 836: 834: 828: 824: 821: 815: 813: 807: 803: 800: 798:RefSeq (mRNA) 796: 789: 788: 783: 779: 776: 770: 769: 764: 760: 757: 755: 751: 744: 743: 738: 734: 731: 725: 724: 719: 715: 712: 710: 706: 699: 698: 693: 689: 686: 680: 679: 674: 670: 667: 665: 661: 658: 655: 653: 650: 646: 643: 639: 635: 628: 624: 619: 613: 610: 608: 605: 603: 600: 598: 595: 594: 592: 589: 588: 582: 579: 577: 574: 572: 569: 567: 564: 563: 561: 558: 557: 551: 548: 546: 543: 541: 538: 536: 533: 532: 530: 527: 526: 523: 522:Gene ontology 519: 515: 503: 498: 494: 489: 486: 484: 480: 472: 467: 456: 452: 448: 444: 440: 436: 432: 428: 424: 420: 419: 416: 412: 407: 404: 394: 390: 386: 382: 378: 374: 370: 366: 362: 358: 357: 354: 350: 345: 342: 341: 338: 336: 332: 330: 329: 325: 324: 321: 319: 315: 311: 307: 303: 295: 290: 286: 282: 277: 267: 263: 256: 249: 243: 236: 228: 224: 220: 215: 211: 206: 202: 194: 189: 185: 181: 176: 166: 162: 155: 148: 142: 135: 131: 125: 121: 117: 112: 108: 103: 99: 95: 91: 87: 83: 79: 75: 71: 67: 63: 59: 51: 46: 39: 34: 29: 25: 20: 5422: 4518:transporter 4471:transporter 3557:transporter 3376: 3368:transporter 2751:- dependent 2311: 2305:Transporters 2199: 2195: 2155: 2151: 2120: 2116: 2082:(6): 663–6. 2079: 2075: 2048: 2044: 2007: 2003: 1967: 1963: 1934: 1930: 1898:(2): 321–8. 1895: 1891: 1855:(4): 353–8. 1852: 1848: 1819: 1815: 1780: 1776: 1743: 1739: 1706: 1702: 1659: 1655: 1648: 1613: 1609: 1599: 1562: 1558: 1548: 1511: 1507: 1497: 1467:(1): 114–8. 1464: 1460: 1453: 1423:(9): 606–9. 1420: 1416: 1410: 1375: 1371: 1361: 1347: 1315:(1): 41–53. 1312: 1308: 1298: 1271: 1267: 1227: 1223: 1217: 1208: 1199: 1190: 1181: 1111: 1105: 1101: 1099: 1094: 1083: 1073: 1028:, elevated T 1010: 984: 971: 963: 959: 958: 881: 856: 830: 809: 785: 766: 740: 721: 695: 676: 656: 651: 445:human kidney 433:right kidney 333: 326: 292:102,865,589 279:102,741,020 53:External IDs 4378:zinc efflux 1074:A knockout 1036:(ratio of T 863:NP_006508.2 395:gallbladder 191:74,533,917 178:74,421,493 31:Identifiers 5439:Categories 5404:Cl-oxalate 5399:Cl-formate 5326:Na/glucose 4516:Acetyl-CoA 1783:: 118–26. 1176:, May 2017 1155:, May 2017 1132:References 987:thyronines 337:(ortholog) 74:HomoloGene 5423:see also 5295:Symporter 5283:Ion pumps 1676:1095-6840 1632:1945-7170 1076:zebrafish 1070:Zebrafish 1014:hypotonic 884:NP_033223 859:NP_006508 833:NM_009197 812:NM_006517 642:Orthologs 82:GeneCards 5392:(Band 3) 5376:Na/(Ca-K 4946:SLC41–48 4899:SLC39A14 4894:SLC39A13 4889:SLC39A12 4884:SLC39A11 4879:SLC39A10 4811:SLC38A10 4452:SLC31–40 4428:SLC30A10 4242:SLC26A11 4237:SLC26A10 4169:SLC25A46 4164:SLC25A45 4159:SLC25A44 4154:SLC25A43 4149:SLC25A42 4144:SLC25A41 4139:SLC25A40 4134:SLC25A39 4129:SLC25A38 4124:SLC25A37 4119:SLC25A36 4114:SLC25A35 4109:SLC25A34 4104:SLC25A33 4099:SLC25A32 4094:SLC25A31 4089:SLC25A30 4084:SLC25A29 4079:SLC25A28 4074:SLC25A27 4069:SLC25A26 4064:SLC25A25 4059:SLC25A24 4054:SLC25A23 4049:SLC25A22 4044:SLC25A21 4039:SLC25A20 4034:SLC25A19 4029:SLC25A18 4024:SLC25A17 4019:SLC25A16 4014:SLC25A15 4009:SLC25A14 4004:SLC25A13 3999:SLC25A12 3994:SLC25A11 3989:SLC25A10 3835:SLC22A20 3830:SLC22A19 3825:SLC22A18 3820:SLC22A17 3815:SLC22A16 3810:SLC22A15 3805:SLC22A14 3800:SLC22A13 3795:SLC22A12 3790:SLC22A11 3785:SLC22A10 3624:SLC21–30 3555:thiamine 3437:SLC16A14 3432:SLC16A13 3427:SLC16A12 3422:SLC16A11 3417:SLC16A10 3145:SLC11–20 2749:chloride 2392:By group 2218:17356046 2174:17081983 2139:16887882 2104:31994320 2096:15834651 2067:15661862 2032:37520843 2024:15488219 1994:14661163 1931:Genomics 1807:17684393 1768:25232696 1760:16957765 1731:15498611 1723:12739169 1684:20417208 1640:28591769 1591:25255244 1540:25255244 1489:27740314 1481:19194886 1437:21415082 1402:14661163 1339:15889350 1290:12871948 1172:– 1151:– 1120:See also 981:Function 932:Wikidata 621:Sources: 576:membrane 441:ligament 5307:Na/K,Cl 5221:SLCO1–4 5181:SLC47A2 5176:SLC47A1 5153:SLC46A2 5148:SLC46A1 5125:SLC45A4 5120:SLC54A3 5115:SLC45A2 5110:SLC45A1 5087:SLC44A5 5082:SLC44A4 5077:SLC44A3 5072:SLC44A2 5067:SLC44A1 5044:SLC43A3 5039:SLC43A2 5034:SLC43A1 4978:SLC41A3 4973:SLC41A2 4968:SLC41A1 4922:SLC40A1 4874:SLC39A9 4869:SLC39A8 4864:SLC39A7 4859:SLC39A6 4854:SLC39A5 4849:SLC39A4 4844:SLC39A3 4839:SLC39A2 4834:SLC39A1 4806:SLC38A6 4801:SLC38A5 4796:SLC38A4 4791:SLC38A3 4786:SLC38A2 4781:SLC38A1 4758:SLC37A4 4753:SLC37A3 4748:SLC37A2 4743:SLC37A1 4717:SLC36A4 4712:SLC36A3 4707:SLC36A2 4702:SLC36A1 4679:SLC35E4 4674:SLC35E3 4669:SLC35E2 4664:SLC35E1 4655:SLC35D3 4650:SLC35D2 4645:SLC35D1 4636:SLC35C2 4631:SLC35C1 4622:SLC35B4 4617:SLC35B3 4612:SLC35B2 4607:SLC35B1 4598:SLC35A5 4593:SLC35A4 4588:SLC35A3 4583:SLC35A2 4578:SLC35A1 4555:SLC34A3 4550:SLC34A2 4545:SLC34A1 4522:SLC33A1 4498:SLC32A1 4475:SLC31A1 4423:SLC30A9 4418:SLC30A8 4413:SLC30A7 4408:SLC30A6 4403:SLC30A5 4398:SLC30A4 4393:SLC30A3 4388:SLC30A2 4383:SLC30A1 4360:SLC29A4 4355:SLC29A3 4350:SLC29A2 4345:SLC29A1 4322:SLC28A3 4317:SLC28A2 4312:SLC28A1 4290:SLC27A6 4285:SLC27A5 4280:SLC27A4 4275:SLC27A3 4270:SLC27A2 4265:SLC27A1 4232:SLC26A9 4227:SLC26A8 4222:SLC26A7 4217:SLC26A6 4212:SLC26A5 4207:SLC26A4 4202:SLC26A3 4197:SLC26A2 4192:SLC26A1 3984:SLC25A9 3979:SLC25A8 3974:SLC25A7 3969:SLC25A6 3964:SLC25A5 3959:SLC25A4 3954:SLC25A3 3949:SLC25A2 3944:SLC25A1 3921:SLC24A6 3916:SLC24A5 3911:SLC24A4 3906:SLC24A3 3901:SLC24A2 3896:SLC24A1 3873:SLC23A4 3868:SLC23A3 3863:SLC23A2 3858:SLC23A1 3780:SLC22A9 3775:SLC22A8 3770:SLC22A7 3765:SLC22A6 3760:SLC22A5 3755:SLC22A4 3750:SLC22A3 3745:SLC22A2 3740:SLC22A1 3716:SLCO6A1 3712:SLCO5A1 3703:SLCO4C1 3698:SLCO4A1 3689:SLCO3A1 3680:SLCO2B1 3675:SLCO2A1 3666:SLCO1C1 3661:SLCO1B4 3656:SLCO1B3 3651:SLCO1B1 3646:SLCO1A2 3600:SLC20A2 3595:SLC20A1 3571:SLC19A3 3566:SLC19A2 3561:SLC19A1 3533:SLC18A3 3528:SLC18A2 3523:SLC18A1 3500:SLC17A9 3495:SLC17A8 3490:SLC17A7 3485:SLC17A6 3480:SLC17A5 3475:SLC17A4 3470:SLC17A3 3465:SLC17A2 3460:SLC17A1 3412:SLC16A9 3407:SLC16A8 3402:SLC16A7 3397:SLC16A6 3392:SLC16A5 3387:SLC16A4 3382:SLC16A3 3377:SLC16A2 3372:SLC16A1 3348:SLC15A4 3343:SLC15A3 3338:SLC15A2 3333:SLC15A1 3310:SLC14A2 3305:SLC14A1 3282:SLC13A5 3277:SLC13A4 3272:SLC13A3 3267:SLC13A2 3262:SLC13A1 3239:SLC12A9 3234:SLC12A8 3229:SLC12A7 3224:SLC12A6 3219:SLC12A5 3214:SLC12A4 3209:SLC12A3 3204:SLC12A2 3199:SLC12A1 3172:SLC11A2 3167:SLC11A1 3101:SLC10A7 3096:SLC10A6 3091:SLC10A5 3086:SLC10A4 3081:SLC10A3 3076:SLC10A2 3071:SLC10A1 3048:SLC9A11 3043:SLC9A10 2942:SLC7A14 2937:SLC7A13 2932:SLC7A11 2927:SLC7A10 2853:SLC6A20 2848:SLC6A19 2843:SLC6A18 2838:SLC6A17 2833:SLC6A16 2828:SLC6A15 2823:SLC6A14 2818:SLC6A13 2813:SLC6A12 2808:SLC6A11 2803:SLC6A10 2407:SLC1–10 2322:Pendrin 2265:Enzymes 2182:7827573 1985:1181904 1951:9545634 1922:9425115 1913:1219047 1879:9110174 1836:8619474 1582:4177677 1531:4177677 1445:1157351 1393:1181904 1330:1226193 1244:7981683 1174:Ensembl 1153:Ensembl 1095:Xenopus 1051:lactate 972:SLC16A2 968:protein 754:UniProt 709:Ensembl 648:Species 627:QuickGO 312:pattern 86:SLC16A2 70:1203732 45:SLC16A2 38:Aliases 22:SLC16A2 4469:copper 3551:folate 3038:SLC9A9 3033:SLC9A8 3028:SLC9A7 3023:SLC9A6 3018:SLC9A5 3013:SLC9A4 3008:SLC9A3 3003:SLC9A2 2998:SLC9A1 2975:SLC8A3 2970:SLC8A2 2965:SLC8A1 2922:SLC7A9 2917:SLC7A8 2912:SLC7A7 2907:SLC7A6 2902:SLC7A5 2889:SLC7A4 2884:SLC7A3 2879:SLC7A2 2874:SLC7A1 2798:SLC6A9 2793:SLC6A8 2788:SLC6A7 2783:SLC6A6 2778:SLC6A5 2773:SLC6A4 2768:SLC6A3 2763:SLC6A2 2758:SLC6A1 2747:- and 2745:sodium 2672:SLC5A1 2599:SLC4A1 2571:SLC3A1 2482:SLC2A1 2429:SLC1A1 2216:  2180:  2172:  2137:  2102:  2094:  2065:  2030:  2022:  2004:Lancet 1992:  1982:  1949:  1920:  1910:  1877:  1870:139146 1867:  1834:  1805:  1795:  1766:  1758:  1729:  1721:  1682:  1674:  1638:  1630:  1589:  1579:  1538:  1528:  1487:  1479:  1443:  1435:  1400:  1390:  1337:  1327:  1288:  1242:  1088:myelin 918:search 916:PubMed 787:O70324 768:P36021 664:Entrez 483:BioGPS 170:Xq13.2 62:300095 5371:Na/Ca 5321:Na/Cl 5192:(48): 5164:(47): 5136:(46): 5098:(45): 5055:(44): 5022:(43): 4989:(42): 4956:(41): 4910:(40): 4822:(39): 4769:(38): 4731:(37): 4690:(36): 4566:(35): 4533:(34): 4509:(33): 4486:(32): 4462:(31): 4371:(30): 4333:(29): 4301:(28): 4253:(27): 4180:(26): 3932:(25): 3884:(24): 3846:(23): 3728:(22): 3634:(21): 3582:(20): 3544:(19): 3511:(18): 3448:(17): 3359:(16): 3321:(15): 3293:(14): 3250:(13): 3186:(12): 3155:(11): 3059:(10): 2379:TC 2A 2178:S2CID 2100:S2CID 2028:S2CID 1764:S2CID 1727:S2CID 1485:S2CID 1441:S2CID 697:20502 657:Mouse 652:Human 623:Amigo 335:Mouse 328:Human 275:Start 210:Mouse 174:Start 107:Human 78:39495 5378:) - 5366:Na/H 5336:Cl/K 5331:Na/I 5312:Na/P 5256:O4A1 5251:O431 5246:O2B1 5241:O1B3 5236:O1B1 5231:O1A2 5011:RhCG 5006:RhBG 5001:RhAG 4720:36A2 3175:11A3 3123:10A7 3118:10A3 3113:10A2 3108:10A1 2986:(9): 2953:(8): 2864:(7): 2738:(6): 2660:(5): 2587:(4): 2558:(3): 2470:(2): 2417:(1): 2214:PMID 2170:PMID 2152:Cell 2135:PMID 2092:PMID 2063:PMID 2020:PMID 1990:PMID 1947:PMID 1918:PMID 1875:PMID 1832:PMID 1803:PMID 1793:ISBN 1756:PMID 1719:PMID 1680:PMID 1672:ISSN 1636:PMID 1628:ISSN 1587:PMID 1536:PMID 1477:PMID 1433:PMID 1398:PMID 1335:PMID 1286:PMID 1240:PMID 1110:and 1102:mct8 996:and 975:gene 964:MCT8 678:6567 318:Bgee 266:Band 227:Chr. 165:Band 124:Chr. 58:OMIM 5382:HCO 5380:Cl/ 2204:doi 2160:doi 2156:127 2125:doi 2084:doi 2080:252 2053:doi 2049:146 2012:doi 2008:364 1980:PMC 1972:doi 1939:doi 1908:PMC 1900:doi 1896:329 1865:PMC 1857:doi 1824:doi 1820:236 1785:doi 1748:doi 1711:doi 1707:447 1664:doi 1660:168 1618:doi 1614:158 1577:PMC 1567:doi 1526:PMC 1516:doi 1469:doi 1425:doi 1388:PMC 1380:doi 1325:PMC 1317:doi 1276:doi 1272:278 1232:doi 1084:the 1026:TSH 288:End 187:End 90:OMA 66:MGI 5441:: 5297:, 2727:12 2722:11 2717:10 2649:11 2644:10 2547:14 2542:13 2537:12 2532:11 2527:10 2370:: 2366:, 2212:. 2200:92 2198:. 2194:. 2176:. 2168:. 2154:. 2150:. 2133:. 2121:20 2119:. 2115:. 2098:. 2090:. 2078:. 2061:. 2047:. 2043:. 2026:. 2018:. 2006:. 1988:. 1978:. 1968:74 1966:. 1962:. 1945:. 1935:48 1933:. 1916:. 1906:. 1894:. 1890:. 1873:. 1863:. 1851:. 1847:. 1830:. 1818:. 1801:. 1791:. 1781:10 1779:. 1762:. 1754:. 1742:. 1725:. 1717:. 1705:. 1678:. 1670:. 1658:. 1634:. 1626:. 1612:. 1608:. 1585:. 1575:. 1563:10 1561:. 1557:. 1534:. 1524:. 1512:10 1510:. 1506:. 1483:. 1475:. 1465:65 1463:. 1439:. 1431:. 1421:48 1419:. 1396:. 1386:. 1376:74 1374:. 1370:. 1333:. 1323:. 1313:77 1311:. 1307:. 1284:. 1270:. 1266:. 1252:^ 1238:. 1226:. 1207:. 1189:. 1160:^ 1139:^ 1116:. 1057:/T 1040:/T 1003:. 977:. 625:/ 294:bp 281:bp 193:bp 180:bp 88:; 84:: 80:; 76:: 72:; 68:: 64:; 60:: 5387:3 5346:5 5341:4 5316:3 5314:i 4310:( 3718:) 3714:( 3553:/ 2712:9 2707:8 2702:7 2697:6 2692:5 2687:4 2682:3 2677:2 2639:9 2634:8 2629:7 2624:6 2619:5 2614:4 2609:3 2604:2 2576:2 2522:9 2517:8 2512:7 2507:6 2502:5 2497:4 2492:3 2487:2 2459:7 2454:6 2449:5 2444:4 2439:3 2434:2 2381:) 2377:( 2356:e 2349:t 2342:v 2284:/ 2249:e 2242:t 2235:v 2220:. 2206:: 2184:. 2162:: 2141:. 2127:: 2106:. 2086:: 2069:. 2055:: 2034:. 2014:: 1996:. 1974:: 1953:. 1941:: 1924:. 1902:: 1881:. 1859:: 1853:7 1838:. 1826:: 1809:. 1787:: 1770:. 1750:: 1744:2 1733:. 1713:: 1686:. 1666:: 1642:. 1620:: 1593:. 1569:: 1542:. 1518:: 1491:. 1471:: 1447:. 1427:: 1404:. 1382:: 1355:. 1341:. 1319:: 1292:. 1278:: 1246:. 1234:: 1228:3 1211:. 1193:. 1059:3 1055:4 1042:4 1038:3 1034:4 1030:3 1000:4 998:T 993:3 991:T 962:( 212:) 109:) 92::

Index

Aliases
SLC16A2
OMIM
300095
MGI
1203732
HomoloGene
39495
GeneCards
SLC16A2
OMA
SLC16A2 - orthologs
Human
X chromosome (human)
Chr.
X chromosome (human)
X chromosome (human)
Genomic location for SLC16A2
Genomic location for SLC16A2
Band
bp
bp
Mouse
X chromosome (mouse)
Chr.
X chromosome (mouse)
Genomic location for SLC16A2
Genomic location for SLC16A2
Band
bp

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