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NFE2L2 (or NRF2) is a basic leucine zipper (bZIP) protein that regulates the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation. Several drugs that stimulate the NFE2L2 pathway are being studied for treatment of diseases that are caused by
1255:
747:
Matthew Dodson et al., Modulating NRF2 in
Disease: Timing Is Everything, Annual Review of Pharmacology and Toxicology, Vol. 59, January 2019, Review in Advance first posted online on 26 September 2018,
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512:, to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults. It is taken
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693:"Biogen Idec's Tecfidera (Dimethyl Fumarate) Approved in US as a First-Line Oral Treatment for Multiple Sclerosis"
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838:
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870:"International nonproprietary names for pharmaceutical substances (INN) : recommended INN: list 80"
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1311:
1235:
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349:
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1061:
788:"Biogen and Alkermes Announce FDA Approval of Vumerity (diroximel fumarate) for Multiple Sclerosis"
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719:"Drug Approval Package: Tecfidera (dimethyl fumarate) Delayed-Release Capsules NDA #204063"
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550:(Nuclear factor erythroid 2-related factor 2) transcription factor.
538:
It was approved for medical use in the United States in April 2020.
282:
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293:
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894:
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62:
338:
695:(Press release). Biogen Idec. 27 March 2013. Archived from
570:(brand name Vumerity), approved by the FDA in October 2019.
1347:
Megalencephalic leukoencephalopathy with subcortical cysts
482:
InChI=1S/C5H6O4/c1-9-5(8)3-2-4(6)7/h2-3H,1H3,(H,6,7)/b3-2+
1477:
750:
https://doi.org/10.1146/annurev-pharmtox-010818-021856
1423:
1057:
Lesional demyelinations of the central nervous system
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1246:Chronic inflammatory demyelinating polyneuropathy
201:
1342:Leukoencephalopathy with vanishing white matter
176:
1533:Antineoplastic and immunomodulating drug stubs
1497:
906:
762:"Vumerity (Previously BIIB098 and ALKS 8700)"
508:used for the treatment of relapsing forms of
8:
71:
21:
1504:
1490:
1213:
913:
899:
891:
375:
352:
241:
29:
1294:Experimental autoimmune encephalomyelitis
261:
1398:List of multiple sclerosis organizations
613:"Bafiertam- monomethyl fumarate capsule"
1430:
597:
479:
459:
348:
221:
156:
1403:List of people with multiple sclerosis
1279:Neuromyelitis optica spectrum disorder
1226:Neuromyelitis optica spectrum disorder
813:"Vumerity- diroximel fumarate capsule"
519:The most common adverse reactions are
366:
20:
321:
301:
7:
1451:
1449:
1378:Mitochondrial DNA depletion syndrome
1264:Acute disseminated encephalomyelitis
159:(2E)-4-methoxy-4-oxobut-2-enoic acid
281:
192:
1476:. You can help Knowledge (XXG) by
868:World Health Organization (2020).
667:"Drug Approval Package: Bafiertam"
557:Two precursors are also approved:
14:
839:"Drug Approval Package: Vumerity"
586:international nonproprietary name
1453:
1433:
1408:Multiple sclerosis drug pipeline
1284:Diffuse myelinoclastic sclerosis
1274:Marburg acute multiple sclerosis
1231:Diffuse myelinoclastic sclerosis
1085:Management of multiple sclerosis
1052:Radiologically isolated syndrome
1032:Expanded Disability Status Scale
400:
1005:Diagnosis of multiple sclerosis
638:"Bafiertam: FDA-Approved Drugs"
546:Monomethyl fumarate alters the
487:Key:NKHAVTQWNUWKEO-NSCUHMNNSA-N
1523:Drugs not assigned an ATC code
1289:Tumefactive multiple sclerosis
1201:Research in multiple sclerosis
921:Demyelinating diseases of the
406:
394:
1:
766:Multiple Sclerosis News Today
1368:Central pontine myelinolysis
1337:Pelizaeus–Merzbacher disease
1332:Metachromatic leukodystrophy
1027:Clinically isolated syndrome
998:Investigations and diagnosis
845:Food and Drug Administration
725:Food and Drug Administration
671:Food and Drug Administration
644:Food and Drug Administration
500:, sold under the brand name
1373:Marchiafava–Bignami disease
584:Monomethyl fumarate is the
1549:
1448:
384:Chemical and physical data
1269:Balo concentric sclerosis
470:
450:
147:
28:
673:(FDA). 30 November 2020
564:(brand name Tecfidera),
1210:Demyelinating diseases
923:central nervous system
1312:Adrenoleukodystrophy
1236:MOG antibody disease
1038:Serological and CSF
989:Uhthoff's phenomenon
877:WHO Drug Information
1140:Monomethyl fumarate
575:Society and culture
498:Monomethyl fumarate
73:Monomethyl fumarate
25:
23:Monomethyl fumarate
1528:Multiple sclerosis
1241:Multiple sclerosis
1125:Interferon beta-1b
1120:Interferon beta-1a
1115:Glatiramer acetate
1105:Diroximel fumarate
1078:Approved treatment
931:Signs and symptoms
729:. 24 December 1999
568:Diroximel fumarate
554:oxidative stress.
510:multiple sclerosis
1485:
1484:
1421:
1420:
1386:
1385:
1317:Alexander disease
1100:Dimethyl fumarate
1042:Oligoclonal bands
1010:McDonald criteria
768:. 1 November 2019
562:Dimethyl fumarate
495:
494:
441:Interactive image
334:CompTox Dashboard
131:
65:
16:Chemical compound
1540:
1506:
1499:
1492:
1467:immunomodulatory
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1438:
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1214:
1184:Other treatments
1062:Dawson's fingers
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462:COC(=O)C=CC(=O)O
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1434:
1432:
1424:
1422:
1417:
1413:Pathophysiology
1382:
1356:
1352:CAMFAK syndrome
1322:Canavan disease
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1205:
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925:
919:
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888:
872:
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849:. 21 April 2020
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819:. 30 March 2020
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350:DTXSID801016498
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17:
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1463:antineoplastic
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1327:Krabbe disease
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1154:+hyaluronidase
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1017:Poser criteria
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979:Optic neuritis
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699:on 12 May 2013
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525:abdominal pain
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1472:article is a
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1175:Teriflunomide
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1048:Radiological
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367:ECHA InfoCard
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38:Clinical data
36:
32:
27:
19:
1478:expanding it
1460:
1445:
1256:Inflammatory
1139:
1135:Mitoxantrone
969:Incontinence
880:
876:
863:
851:. Retrieved
842:
833:
821:. Retrieved
816:
807:
795:. Retrieved
791:
782:
770:. Retrieved
765:
756:
743:
731:. Retrieved
722:
713:
701:. Retrieved
697:the original
687:
675:. Retrieved
661:
649:. Retrieved
641:
632:
620:. Retrieved
616:
583:
556:
552:
545:
542:Pharmacology
537:
518:
501:
497:
496:
323:ChEMBL589586
303:CHEBI:167450
119:Legal status
113:Legal status
54:License data
18:
1150:Ocrelizumab
1145:Natalizumab
1090:Alemtuzumab
797:21 February
772:21 February
677:13 February
622:13 February
424: g·mol
373:100.018.557
143:Identifiers
44:Trade names
1517:Categories
1304:Hereditary
1218:Autoimmune
1194:Daclizumab
1130:Laquinimod
1110:Fingolimod
1095:Cladribine
1069:Frexalimab
954:Dysarthria
944:Depression
592:References
506:medication
429:3D model (
417:Molar mass
263:45IUB1PX8R
234:ChemSpider
169:CAS Number
152:IUPAC name
1170:Siponimod
1165:Ponesimod
1023:Clinical
974:Nystagmus
959:Dysphagia
502:Bafiertam
178:2756-87-8
84:Routes of
48:Bafiertam
1440:Medicine
1160:Ozanimod
949:Diplopia
883:(1): 74.
817:DailyMed
651:29 April
617:DailyMed
529:diarrhea
521:flushing
514:by mouth
214:DrugBank
98:ATC code
91:By mouth
68:DailyMed
1190:Former
964:Fatigue
853:30 June
823:30 June
733:30 June
669:. U.S.
588:(INN).
422:130.099
390:Formula
243:4520322
223:DB14219
203:5369209
189:PubChem
70::
1426:Portal
939:Ataxia
792:Biogen
703:4 June
548:NFE2L2
533:nausea
531:, and
455:SMILES
314:ChEMBL
283:D11492
134:â„ž-only
132:
66:
1461:This
1391:Other
1361:Other
873:(PDF)
847:(FDA)
843:U.S.
727:(FDA)
723:U.S.
646:(FDA)
642:U.S.
580:Names
504:is a
475:InChI
431:JSmol
294:ChEBI
1474:stub
1470:drug
984:Pain
855:2020
825:2020
799:2020
774:2020
735:2020
705:2013
679:2022
653:2020
624:2022
274:KEGG
254:UNII
105:None
1465:or
339:EPA
193:CID
1519::
881:34
879:.
875:.
841:.
815:.
790:.
764:.
721:.
640:.
615:.
600:^
535:.
527:,
523:,
516:.
128:US
63:US
1505:e
1498:t
1491:v
1480:.
1428::
1156:)
1152:(
914:e
907:t
900:v
857:.
827:.
801:.
776:.
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707:.
681:.
655:.
626:.
433:)
410:4
407:O
404:6
401:H
398:5
395:C
341:)
337:(
130::
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