830:
625:
Monopolin is composed of a 4 CSM1:2 LRS4 complex which forms a V-shaped structure with two globular heads at the ends, which are responsible for directly crosslinking sister kinetochores. Bound to each CSM1 head is a MAM1 protein which recruits one copy of the HRR25 kinase. The hydrophobic cavity on
706:
Plowman, Rebecca; Singh, Namit; Tromer, Eelco C.; Payan, Angel; Duro, Eris; Spanos, Christos; Rappsilber, Juri; Snel, Berend; Kops, Geert J. P.L.; Corbett, Kevin D.; Marston, Adele L. (2019-09-01).
498:
486:
362:
350:
214:
202:
78:
66:
397:
533:
261:
113:
634:
can then attach to the kinetochores on the homologous centromeres and pull them toward opposite mitotic spindles to complete anaphase of meiosis I.
871:
479:
343:
195:
59:
900:
895:
864:
614:
within the centromere to physically fuse them and allow for the microtubules to pull each homolog toward opposite
243:
456:
320:
172:
36:
905:
857:
656:"The monopolin complex crosslinks kinetochore components to regulate chromosome-microtubule attachments"
626:
the CSM1 subunit allows the hydrophobic regions of
Monopolin receptor and kinetochore protein,
890:
806:
788:
747:
729:
685:
615:
841:
796:
778:
737:
719:
675:
667:
587:
595:
591:
553:
417:
281:
248:
133:
801:
766:
742:
707:
680:
655:
884:
491:
355:
207:
71:
611:
783:
503:
367:
219:
83:
631:
563:
427:
291:
143:
724:
671:
599:
527:
510:
391:
374:
255:
226:
107:
90:
792:
733:
810:
751:
689:
515:
379:
231:
95:
837:
603:
579:
829:
654:
Corbett KD, Yip CK, Ee LS, Walz T, Amon A, Harrison SC (August 2010).
474:
338:
190:
54:
708:"The molecular basis of monopolin recruitment to the kinetochore"
627:
607:
583:
582:
complex that in budding yeast is composed of the four proteins
598:. Monopolin is required for the segregation of homologous
845:
767:"Molecular Architecture of the Yeast Monopolin Complex"
765:
Corbett, Kevin D.; Harrison, Stephen C. (2012-06-28).
559:
549:
544:
526:
521:
509:
497:
485:
473:
465:
451:
446:
441:
423:
413:
408:
390:
385:
373:
361:
349:
337:
329:
315:
310:
305:
287:
277:
272:
254:
242:
237:
225:
213:
201:
189:
181:
167:
162:
157:
139:
129:
124:
106:
101:
89:
77:
65:
53:
45:
31:
26:
21:
630:, to bind to and fuse the sister kinetochores.
649:
647:
865:
8:
602:to opposite poles of a dividing cell during
872:
858:
541:
405:
269:
121:
800:
782:
741:
723:
679:
643:
438:
302:
154:
18:
7:
826:
824:
701:
699:
844:. You can help Knowledge (XXG) by
14:
828:
442:Monopolin complex subunit MAM1
306:Monopolin complex subunit LRS4
22:Monopolin complex subunit CSM1
1:
158:Casein kinase I homolog HRR25
784:10.1016/j.celrep.2012.05.012
922:
823:
725:10.1007/s00412-019-00700-0
672:10.1016/j.cell.2010.07.017
606:. This occurs by bridging
540:
404:
268:
120:
610:kinetochore proteins to
840:-related article is a
604:anaphase I of meiosis
621:Molecular structure
612:sister kinetochores
262:XVI: 0.16 - 0.17 Mb
114:III: 0.26 - 0.26 Mb
398:IV: 1.34 - 1.34 Mb
901:Protein complexes
896:Molecular biology
853:
852:
616:mitotic spindles.
573:
572:
569:
568:
534:V: 0.37 - 0.37 Mb
437:
436:
433:
432:
301:
300:
297:
296:
153:
152:
149:
148:
913:
874:
867:
860:
832:
825:
815:
814:
804:
786:
762:
756:
755:
745:
727:
703:
694:
693:
683:
651:
542:
461:
439:
406:
325:
303:
270:
177:
155:
122:
41:
19:
921:
920:
916:
915:
914:
912:
911:
910:
881:
880:
879:
878:
821:
819:
818:
764:
763:
759:
705:
704:
697:
653:
652:
645:
640:
623:
455:
319:
171:
35:
17:
16:Protein complex
12:
11:
5:
919:
917:
909:
908:
903:
898:
893:
883:
882:
877:
876:
869:
862:
854:
851:
850:
833:
817:
816:
777:(6): 583–589.
757:
718:(3): 331–354.
695:
642:
641:
639:
636:
622:
619:
571:
570:
567:
566:
561:
557:
556:
551:
547:
546:
538:
537:
530:
524:
523:
519:
518:
513:
507:
506:
501:
495:
494:
489:
483:
482:
477:
471:
470:
467:
463:
462:
453:
449:
448:
444:
443:
435:
434:
431:
430:
425:
421:
420:
415:
411:
410:
402:
401:
394:
388:
387:
383:
382:
377:
371:
370:
365:
359:
358:
353:
347:
346:
341:
335:
334:
331:
327:
326:
317:
313:
312:
308:
307:
299:
298:
295:
294:
289:
285:
284:
279:
275:
274:
266:
265:
258:
252:
251:
246:
240:
239:
235:
234:
229:
223:
222:
217:
211:
210:
205:
199:
198:
193:
187:
186:
183:
179:
178:
169:
165:
164:
160:
159:
151:
150:
147:
146:
141:
137:
136:
131:
127:
126:
118:
117:
110:
104:
103:
99:
98:
93:
87:
86:
81:
75:
74:
69:
63:
62:
57:
51:
50:
47:
43:
42:
33:
29:
28:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
918:
907:
906:Protein stubs
904:
902:
899:
897:
894:
892:
889:
888:
886:
875:
870:
868:
863:
861:
856:
855:
849:
847:
843:
839:
834:
831:
827:
822:
812:
808:
803:
798:
794:
790:
785:
780:
776:
772:
768:
761:
758:
753:
749:
744:
739:
735:
731:
726:
721:
717:
713:
709:
702:
700:
696:
691:
687:
682:
677:
673:
669:
666:(4): 556–67.
665:
661:
657:
650:
648:
644:
637:
635:
633:
629:
620:
618:
617:
613:
609:
605:
601:
597:
593:
589:
585:
581:
577:
565:
562:
558:
555:
552:
548:
543:
539:
536:
535:
531:
529:
525:
520:
517:
514:
512:
508:
505:
502:
500:
499:RefSeq (Prot)
496:
493:
490:
488:
487:RefSeq (mRNA)
484:
481:
478:
476:
472:
468:
464:
460:
459:
458:S. cerevisiae
454:
450:
445:
440:
429:
426:
422:
419:
416:
412:
407:
403:
400:
399:
395:
393:
389:
384:
381:
378:
376:
372:
369:
366:
364:
363:RefSeq (Prot)
360:
357:
354:
352:
351:RefSeq (mRNA)
348:
345:
342:
340:
336:
332:
328:
324:
323:
322:S. cerevisiae
318:
314:
309:
304:
293:
290:
286:
283:
280:
276:
271:
267:
264:
263:
259:
257:
253:
250:
247:
245:
241:
236:
233:
230:
228:
224:
221:
218:
216:
215:RefSeq (Prot)
212:
209:
206:
204:
203:RefSeq (mRNA)
200:
197:
194:
192:
188:
184:
180:
176:
175:
174:S. cerevisiae
170:
166:
161:
156:
145:
142:
138:
135:
132:
128:
123:
119:
116:
115:
111:
109:
105:
100:
97:
94:
92:
88:
85:
82:
80:
79:RefSeq (Prot)
76:
73:
70:
68:
67:RefSeq (mRNA)
64:
61:
58:
56:
52:
48:
44:
40:
39:
38:S. cerevisiae
34:
30:
25:
20:
846:expanding it
835:
820:
774:
771:Cell Reports
770:
760:
715:
711:
663:
659:
632:Microtubules
624:
575:
574:
532:
492:NM_001178997
457:
396:
356:NM_001180747
321:
260:
208:NM_001184018
173:
112:
72:NM_001178792
37:
600:centromeres
554:Swiss-model
447:Identifiers
418:Swiss-model
311:Identifiers
282:Swiss-model
163:Identifiers
134:Swiss-model
27:Identifiers
885:Categories
712:Chromosoma
638:References
550:Structures
545:Search for
528:Chromosome
522:Other data
414:Structures
409:Search for
392:Chromosome
386:Other data
278:Structures
273:Search for
256:Chromosome
238:Other data
130:Structures
125:Search for
108:Chromosome
102:Other data
793:2211-1247
734:1432-0886
576:Monopolin
504:NP_011032
368:NP_010727
244:EC number
220:NP_015120
84:NP_010009
891:Proteins
811:22813733
752:31037469
690:20723757
564:InterPro
452:Organism
428:InterPro
316:Organism
292:InterPro
249:2.7.11.1
168:Organism
144:InterPro
32:Organism
838:protein
802:3494995
743:6823300
681:2955198
580:protein
560:Domains
511:UniProt
424:Domains
375:UniProt
288:Domains
227:UniProt
140:Domains
91:UniProt
809:
799:
791:
750:
740:
732:
688:
678:
594:, and
516:P40065
480:856843
475:Entrez
466:Symbol
380:Q04087
344:852049
339:Entrez
330:Symbol
232:P29295
196:855897
191:Entrez
182:Symbol
96:P25651
60:850447
55:Entrez
46:Symbol
836:This
588:HRR25
578:is a
185:HRR25
842:stub
807:PMID
789:ISSN
748:PMID
730:ISSN
686:PMID
660:Cell
628:DSN1
608:DSN1
596:MAM1
592:LRS4
584:CSM1
469:MAM1
333:LRS4
49:CSM1
797:PMC
779:doi
738:PMC
720:doi
716:128
676:PMC
668:doi
664:142
887::
805:.
795:.
787:.
773:.
769:.
746:.
736:.
728:.
714:.
710:.
698:^
684:.
674:.
662:.
658:.
646:^
590:,
586:,
873:e
866:t
859:v
848:.
813:.
781::
775:1
754:.
722::
692:.
670::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.