223:
37:
28:
526:
65:
56:
680:
846:
J. A. Dale; H. S. Mosher (1973). "Nuclear magnetic resonance enantiomer regents. Configurational correlations via nuclear magnetic resonance chemical shifts of diastereomeric mandelate, O-methylmandelate, and α-methoxy-α-trifluoromethylphenylacetate (MTPA) esters".
534:
506:
817:
J. A. Dale; D. L. Dull; H. S. Mosher (1969). "α-Methoxy-α-trifluoromethylphenylacetic acid, a versatile reagent for the determination of enantiomeric composition of alcohols and amines".
600:
693:
413:
596:
907:
849:
905:
D. L. Dull; H. S. Mosher (1967). "Aberrant rotatory dispersion curves of α-hydroxy- and α-methoxy-α-trifluoromethylphenylacetic acids".
1002:
180:
378:
588:
700:
878:
819:
570:
301:
347:
624:
525:
1007:
997:
732:
662:
230:
992:
616:
612:
604:
957:
D. E. Ward; C. K. Rhee (1991). "A simple method for the microscale preparation of Mosher's acid chloride".
218:
768:
548:
518:
83:
364:
959:
945:
797:
756:
121:
937:
Allen, Damian A.; Tomaso, Anthony E., Jr.; Priest, Owen P.; Hindson, David F.; Hurlburt, Jamie L.
728:
576:
584:
36:
27:
968:
916:
887:
858:
828:
775:
436:
64:
55:
608:
335:
323:
311:
200:
156:
144:
132:
764:
724:
592:
222:
938:
671:
986:
972:
785:
656:
491:
481:
211:
632:
290:
278:
580:
935:
Mosher Amides: Determining the
Absolute Stereochemistry of Optically-Active Amines
772:
639:
562:
387:
InChI=1S/C10H9F3O3/c1-16-9(8(14)15,10(11,12)13)7-5-3-2-4-6-7/h2-6H,1H3,(H,14,15)
620:
397:
InChI=1/C10H9F3O3/c1-16-9(8(14)15,10(11,12)13)7-5-3-2-4-6-7/h2-6H,1H3,(H,14,15)
463:
191:
876:
Y. Goldberg; H. Alper (1992). "A new and simple synthesis of Mosher's acid".
558:
920:
891:
862:
832:
260:
231:
554:
736:
496:
105 to 107 °C (221 to 225 °F; 378 to 380 K) at 1 torr
670:
Except where otherwise noted, data are given for materials in their
760:
179:
169:
628:
352:
63:
54:
35:
26:
788:
form, is sometimes used because it has better reactivity.
771:
of the ester or amide is then determined by proton and/or
486:
46 to 49 °C (115 to 120 °F; 319 to 322 K)
688:
755:As a chiral derivatizing agent, it reacts with an
289:
277:
155:
143:
131:
109:Methoxy(trifluoromethyl)phenylacetic acid, MTPA
8:
717:α-methoxy-α-trifluoromethylphenylacetic acid
221:
199:
15:
334:
322:
310:
908:Journal of the American Chemical Society
850:Journal of the American Chemical Society
809:
418:
383:
363:
644:110 °C (230 °F; 383 K)
212:
390:Key: JJYKJUXBWFATTE-UHFFFAOYSA-N
7:
400:Key: JJYKJUXBWFATTE-UHFFFAOYAJ
263:
14:
678:
524:
767:to form an ester or amide. The
674:(at 25 °C , 100 kPa).
101:methoxy-2-phenylpropanoic acid
93:methoxy-2-phenylpropanoic acid
1:
421:COC(C(O)=O)(c1ccccc1)C(F)(F)F
973:10.1016/0040-4039(91)80466-J
879:Journal of Organic Chemistry
820:Journal of Organic Chemistry
50:
22:
1024:
1003:Trifluoromethyl compounds
733:chiral derivatizing agent
668:
648:
505:
500:
429:
409:
374:
114:
106:
82:
77:
49:
21:
739:molecule, consisting of
727:which was first used by
571:Precautionary statements
782:Mosher's acid chloride
769:absolute configuration
663:Mosher's acid chloride
68:
59:
40:
31:
67:
58:
39:
30:
468:234.17
99:)-3,3,3-trifluoro-2-
91:)-3,3,3-trifluoro-2-
960:Tetrahedron Letters
921:10.1021/ja00992a053
892:10.1021/jo00039a043
863:10.1021/ja00783a034
833:10.1021/jo01261a013
18:
729:Harry Stone Mosher
701:Infobox references
649:Related compounds
69:
60:
41:
32:
16:
967:(49): 7165–7166.
933:See for example:
886:(13): 3731–3732.
709:Chemical compound
707:
706:
549:Hazard statements
348:CompTox Dashboard
251:): 241-292-1
244:): 243-829-5
181:Interactive image
73:
72:
45:
44:
1015:
1008:Phenyl compounds
998:Carboxylic acids
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954:
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931:
925:
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902:
896:
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873:
867:
866:
843:
837:
836:
827:(9): 2543–2549.
814:
798:Pirkle's alcohol
776:NMR spectroscopy
691:
685:
682:
681:
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614:
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560:
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437:Chemical formula
367:
356:
354:
338:
326:
314:
309:(racemic):
293:
281:
265:
233:
225:
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203:
183:
159:
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135:
130:(racemic):
100:
92:
51:
23:
19:
1023:
1022:
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1016:
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993:Stereochemistry
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982:
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951:
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765:stereochemistry
753:
725:carboxylic acid
710:
703:
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697:
696: ?)
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11:
5:
1021:
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978:
949:
939:J. Chem. Educ.
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857:(2): 512–519.
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672:standard state
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635:
601:P305+P351+P338
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17:Mosher's acid
13:
10:
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6:
4:
3:
2:
1020:
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796:
795:
791:
789:
787:
786:acid chloride
783:
779:
777:
774:
770:
766:
762:
758:
750:
748:
747:enantiomers.
746:
742:
738:
734:
730:
726:
722:
718:
714:
713:Mosher's acid
702:
695:
690:
673:
667:
664:
661:
658:
657:acyl chloride
653:
652:
647:
643:
641:
638:
637:
575:
572:
568:
567:
553:
550:
546:
545:
542:
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532:
531:
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499:
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492:Boiling point
490:
489:
485:
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482:Melting point
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213:ECHA InfoCard
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48:
38:
34:
29:
25:
24:
20:
964:
958:
952:
941:
934:
929:
915:(16): 4230.
912:
906:
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883:
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754:
751:Applications
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507:
330:
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285:
273:
248:
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151:
139:
115:Identifiers
107:Other names
96:
88:
944:, 85, 698.
763:of unknown
640:Flash point
535:Signal word
473:Appearance
430:Properties
219:100.153.604
84:IUPAC names
987:Categories
804:References
735:. It is a
519:Pictograms
464:Molar mass
336:172HCJ1IQV
324:27O5L9T1WM
312:E015GCC0MA
192:ChemSpider
168:3D model (
157:17257-71-5
145:20445-31-2
133:81655-41-6
122:CAS Number
625:P403+P233
617:P337+P313
613:P332+P313
597:P304+P340
593:P302+P352
510:labelling
232:EC Number
946:Abstract
792:See also
655:Related
501:Hazards
333:):
321:):
288:):
276:):
154:):
142:):
757:alcohol
723:) is a
694:what is
692: (
541:Warning
458:
291:6992788
279:2723917
261:PubChem
784:, the
737:chiral
689:verify
686:
476:solid
414:SMILES
78:Names
761:amine
731:as a
715:, or
379:InChI
201:78043
170:JSmol
942:2008
743:and
721:MTPA
633:P501
629:P405
621:P362
609:P321
605:P312
589:P280
585:P271
581:P264
577:P261
563:H335
559:H319
555:H315
302:UNII
969:doi
917:doi
888:doi
859:doi
829:doi
759:or
508:GHS
353:EPA
264:CID
989::
965:32
963:.
913:89
911:.
884:57
882:.
855:95
853:.
825:34
823:.
778:.
631:,
627:,
623:,
619:,
615:,
611:,
607:,
603:,
599:,
595:,
591:,
587:,
583:,
579:,
561:,
557:,
512::
444:10
975:.
971::
923:.
919::
894:.
890::
865:.
861::
835:.
831::
773:F
745:S
741:R
719:(
684:N
456:3
454:O
452:3
450:F
448:9
446:H
442:C
355:)
351:(
331:S
329:(
319:R
317:(
286:S
284:(
274:R
272:(
249:S
247:(
242:R
240:(
172:)
152:S
150:(
140:R
138:(
97:S
95:(
89:R
87:(
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
