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N,N'-Diisopropylcarbodiimide

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45: 36: 332: 227: 518: 513: 498: 508: 503: 1070: 739: 1028:
Sperry, Jeffrey B.; Minteer, Christopher J.; Tao, JingYa; Johnson, Rebecca; Duzguner, Remzi; Hawksworth, Michael; Oke, Samantha; Richardson, Paul F.; Barnhart, Richard; Bill, David R.; Giusto, Robert A.; Weaver, John D. (2018-09-21).
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Graham, Jessica C.; Trejo-Martin, Alejandra; Chilton, Martyn L.; Kostal, Jakub; Bercu, Joel; Beutner, Gregory L.; Bruen, Uma S.; Dolan, David G.; Gomez, Stephen; Hillegass, Jedd; Nicolette, John; Schmitz, Matthew (2022-06-20).
849: 526: 478: 652: 640: 648: 752: 1111: 381: 644: 580: 1104: 916:"Reinvestigation of the reactions of carbodiimides with alkoxycarbonylamino acid symmetrical anhydrides: Isolation of two N ‐acylureas" 1140: 1130: 1155: 853: 680: 346: 1160: 1097: 954: 877:"Comparative studies of the coupling of N-methylated, sterically hindered amino acids during solid-phase peptide synthesis" 1150: 624: 566: 574: 289: 676: 517: 35: 620: 310: 696: 512: 44: 841: 759: 234: 793: 592: 632: 124: 672: 497: 660: 502: 222: 1135: 184: 1031:"Thermal Stability Assessment of Peptide Coupling Reagents Commonly Used in Pharmaceutical Manufacturing" 915: 600: 1145: 540: 507: 490: 876: 664: 656: 57: 822: 327: 90: 588: 700: 608: 144: 604: 616: 1050: 1010: 992: 935: 896: 789: 715: 914:
Izdebski, Jan; Orlowska, Alicja; Anulewicz, Romana; Witkowska, Ewa; Fiertek, Dariusz (1994).
1077: 1042: 1000: 984: 927: 888: 818: 692: 404: 668: 298: 204: 972: 636: 253: 100: 688: 331: 226: 164: 1081: 1005: 931: 730: 1124: 892: 463: 215: 1030: 708: 988: 785: 612: 554: 278: 721: 1069: 817:-diisopropylurea, its byproduct in many chemical reactions, is soluble in most 684: 584: 432: 195: 1054: 1046: 996: 939: 900: 850:
Globally Harmonized System of Classification and Labelling of Chemicals (GHS)
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Angell, Yvonne M.; GarcĂ­a-EcheverrĂ­a, Carlos; Rich, Daniel H. (1994-08-15).
628: 596: 1014: 546: 558: 453: 265: 235: 973:"An Evaluation of the Occupational Health Hazards of Peptide Couplers" 550: 175: 729:
Except where otherwise noted, data are given for materials in their
155: 123: 113: 959:. Paris: Organisation for Economic Co-operation and Development. 845: 837: 704: 562: 852:
Dermal Sensitization Category 1A. Thermal hazard analysis by
792:. As a liquid, it is easier to handle than the commonly used 315: 468:
145 to 148 Â°C (293 to 298 Â°F; 418 to 421 K)
956:
Test No. 429: Skin Sensitisation: Local Lymph Node Assay
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International Journal of Peptide and Protein Research
277: 355:InChI=1S/C7H14N2/c1-6(2)8-5-9-7(3)4/h6-7H,1-4H3 99: 365:InChI=1/C7H14N2/c1-6(2)8-5-9-7(3)4/h6-7H,1-4H3 1105: 8: 1112: 1098: 1035:Organic Process Research & Development 836:dermal sensitization studies according to 330: 225: 203: 15: 1004: 856:shows DIC poses minimal explosion risks. 297: 844:, showing a response at 0.20 wt% in the 867: 854:differential scanning calorimetry (DSC) 386: 351: 326: 216: 358:Key: BDNKZNFMNDZQMI-UHFFFAOYSA-N 183: 163: 7: 1066: 1064: 840:429 confirmed DIC is a strong skin 368:Key: BDNKZNFMNDZQMI-UHFFFAOYAW 268: 932:10.1111/j.1399-3011.1994.tb00521.x 14: 1068: 737: 516: 511: 506: 501: 496: 422: 416: 43: 34: 977:Chemical Research in Toxicology 733:(at 25 Â°C , 100 kPa). 989:10.1021/acs.chemrestox.2c00031 821:, a property that facilitates 410: 78:Diisopropylmethanediimine, DIC 69:-Di(propan-2-yl)methanediimine 1: 846:Local Lymph Node Assay (LLNA) 806:, a waxy solid. In addition, 1084:. You can help Knowledge by 893:10.1016/0040-4039(94)88054-9 1177: 1063: 1141:Reagents for biochemistry 1131:Peptide coupling reagents 804:-dicyclohexylcarbodiimide 727: 477: 472: 397: 377: 342: 83: 75: 56: 51: 42: 33: 1156:Isopropylamino compounds 1047:10.1021/acs.oprd.8b00193 782:-Diisopropylcarbodiimide 575:Precautionary statements 28:-Diisopropylcarbodiimide 1161:Organic compound stubs 1076:This article about an 1151:Biochemistry methods 58:Preferred IUPAC name 881:Tetrahedron Letters 440: g¡mol 145:Beilstein Reference 30: 760:Infobox references 16: 1093: 1092: 887:(33): 5981–5984. 790:peptide synthesis 768:Chemical compound 766: 765: 716:Safety data sheet 541:Hazard statements 311:CompTox Dashboard 125:Interactive image 1168: 1114: 1107: 1100: 1078:organic compound 1072: 1065: 1059: 1058: 1041:(9): 1262–1275. 1025: 1019: 1018: 1008: 983:(6): 1011–1022. 967: 961: 960: 950: 944: 943: 911: 905: 904: 872: 819:organic solvents 815: 802: 780: 750: 744: 741: 740: 710: 706: 702: 698: 694: 690: 686: 682: 678: 674: 670: 666: 662: 658: 654: 650: 646: 642: 638: 634: 630: 626: 622: 618: 614: 610: 606: 602: 598: 594: 590: 586: 582: 568: 564: 560: 556: 552: 548: 520: 515: 510: 505: 500: 439: 424: 418: 412: 405:Chemical formula 335: 334: 319: 317: 301: 281: 270: 254:Gmelin Reference 237: 229: 218: 207: 187: 167: 127: 103: 47: 38: 31: 29: 26: 1176: 1175: 1171: 1170: 1169: 1167: 1166: 1165: 1121: 1120: 1119: 1118: 1062: 1027: 1026: 1022: 969: 968: 964: 952: 951: 947: 913: 912: 908: 874: 873: 869: 865: 859: 831: 813: 800: 778: 769: 762: 757: 756: 755:  ?) 746: 742: 738: 734: 577: 543: 529: 493: 437: 427: 421: 415: 407: 393: 390: 389:CC(C)N=C=NC(C)C 385: 384: 373: 370: 369: 366: 360: 359: 356: 350: 349: 338: 320: 313: 304: 284: 271: 256: 247: 210: 190: 170: 147: 130: 117: 106: 93: 79: 71: 70: 24: 17: 12: 11: 5: 1174: 1172: 1164: 1163: 1158: 1153: 1148: 1143: 1138: 1133: 1123: 1122: 1117: 1116: 1109: 1102: 1094: 1091: 1090: 1073: 1061: 1060: 1020: 962: 945: 926:(2): 184–189. 906: 866: 864: 861: 848:placing it in 830: 827: 767: 764: 763: 758: 736: 735: 731:standard state 728: 725: 724: 719: 712: 711: 653:P305+P351+P338 641:P303+P361+P353 578: 573: 570: 569: 544: 539: 536: 535: 530: 525: 522: 521: 494: 489: 486: 485: 475: 474: 470: 469: 466: 460: 459: 456: 450: 449: 446: 442: 441: 435: 429: 428: 425: 419: 413: 408: 403: 400: 399: 395: 394: 392: 391: 388: 380: 379: 378: 375: 374: 372: 371: 367: 364: 363: 361: 357: 354: 353: 345: 344: 343: 340: 339: 337: 336: 323: 321: 309: 306: 305: 303: 302: 294: 292: 286: 285: 283: 282: 274: 272: 264: 261: 260: 257: 252: 249: 248: 246: 245: 241: 239: 231: 230: 220: 212: 211: 209: 208: 200: 198: 192: 191: 189: 188: 180: 178: 172: 171: 169: 168: 160: 158: 152: 151: 148: 143: 140: 139: 136: 135:Abbreviations 132: 131: 129: 128: 120: 118: 111: 108: 107: 105: 104: 96: 94: 89: 86: 85: 81: 80: 77: 73: 72: 61: 60: 54: 53: 49: 48: 40: 39: 13: 10: 9: 6: 4: 3: 2: 1173: 1162: 1159: 1157: 1154: 1152: 1149: 1147: 1144: 1142: 1139: 1137: 1136:Carbodiimides 1134: 1132: 1129: 1128: 1126: 1115: 1110: 1108: 1103: 1101: 1096: 1095: 1089: 1087: 1083: 1079: 1074: 1071: 1067: 1056: 1052: 1048: 1044: 1040: 1036: 1032: 1024: 1021: 1016: 1012: 1007: 1002: 998: 994: 990: 986: 982: 978: 974: 966: 963: 958: 957: 953:OECD (2010). 949: 946: 941: 937: 933: 929: 925: 921: 917: 910: 907: 902: 898: 894: 890: 886: 882: 878: 871: 868: 862: 860: 857: 855: 851: 847: 843: 839: 835: 828: 826: 824: 820: 816: 809: 805: 803: 796: 791: 787: 783: 781: 774: 761: 754: 749: 732: 726: 723: 722:External MSDS 720: 717: 714: 713: 579: 576: 572: 571: 545: 542: 538: 537: 534: 531: 528: 524: 523: 519: 514: 509: 504: 499: 495: 492: 488: 487: 483: 481: 476: 471: 467: 465: 464:Boiling point 462: 461: 457: 455: 452: 451: 447: 444: 443: 436: 434: 431: 430: 409: 406: 402: 401: 396: 387: 383: 376: 362: 352: 348: 341: 333: 329: 328:DTXSID4025086 325: 324: 322: 312: 308: 307: 300: 296: 295: 293: 291: 288: 287: 280: 276: 275: 273: 267: 263: 262: 258: 255: 251: 250: 243: 242: 240: 238: 233: 232: 228: 224: 221: 219: 217:ECHA InfoCard 214: 213: 206: 202: 201: 199: 197: 194: 193: 186: 185:ChEMBL1332992 182: 181: 179: 177: 174: 173: 166: 162: 161: 159: 157: 154: 153: 149: 146: 142: 141: 137: 134: 133: 126: 122: 121: 119: 115: 110: 109: 102: 98: 97: 95: 92: 88: 87: 82: 74: 68: 64: 59: 55: 50: 46: 41: 37: 32: 27: 20: 1146:Biochemistry 1086:expanding it 1075: 1038: 1034: 1023: 980: 976: 965: 955: 948: 923: 919: 909: 884: 880: 870: 858: 833: 832: 811: 807: 798: 794: 786:carbodiimide 776: 772: 771: 770: 532: 479: 84:Identifiers 76:Other names 66: 62: 22: 18: 527:Signal word 458:0.806 g/mL 445:Appearance 398:Properties 223:100.010.677 165:CHEBI:53092 1125:Categories 863:References 842:sensitizer 491:Pictograms 433:Molar mass 299:OQO20I6TWH 196:ChemSpider 138:DIC, DIPC 112:3D model ( 91:CAS Number 1055:1083-6160 997:0893-228X 940:0367-8377 901:0040-4039 701:P403+P235 697:P403+P233 693:P370+P378 681:P342+P311 677:P333+P313 673:P332+P313 649:P304+P341 645:P304+P340 637:P302+P352 482:labelling 244:211-743-7 236:EC Number 1015:35532537 788:used in 473:Hazards 101:693-13-0 1006:9214767 834:In vivo 823:work-up 753:what is 751: ( 454:Density 448:Liquid 438:126.203 266:PubChem 259:101400 150:878281 1053:  1013:  1003:  995:  938:  899:  829:Safety 748:verify 745:  718:(SDS) 533:Danger 382:SMILES 176:ChEMBL 52:Names 1080:is a 784:is a 347:InChI 279:12734 205:12211 156:ChEBI 114:JSmol 1082:stub 1051:ISSN 1011:PMID 993:ISSN 936:ISSN 897:ISSN 838:OECD 709:P501 705:P405 689:P363 685:P362 669:P321 665:P320 661:P312 657:P310 633:P285 629:P284 625:P280 621:P272 617:P271 613:P264 609:P261 605:P260 601:P243 597:P242 593:P241 589:P240 585:P233 581:P210 567:H334 563:H330 559:H318 555:H317 551:H315 547:H226 290:UNII 1043:doi 1001:PMC 985:doi 928:doi 889:doi 480:GHS 316:EPA 269:CID 1127:: 1049:. 1039:22 1037:. 1033:. 1009:. 999:. 991:. 981:35 979:. 975:. 934:. 924:43 922:. 918:. 895:. 885:35 883:. 879:. 825:. 707:, 703:, 699:, 695:, 691:, 687:, 683:, 679:, 675:, 671:, 667:, 663:, 659:, 655:, 651:, 647:, 643:, 639:, 635:, 631:, 627:, 623:, 619:, 615:, 611:, 607:, 603:, 599:, 595:, 591:, 587:, 583:, 565:, 561:, 557:, 553:, 549:, 484:: 420:14 67:N' 1113:e 1106:t 1099:v 1088:. 1057:. 1045:: 1017:. 987:: 942:. 930:: 903:. 891:: 814:′ 812:N 810:, 808:N 801:′ 799:N 797:, 795:N 779:′ 777:N 775:, 773:N 743:N 426:2 423:N 417:H 414:7 411:C 318:) 314:( 116:) 65:, 63:N 25:′ 23:N 21:, 19:N

Index


Ball-and-stick model of the N,N'-diisopropylcarbodiimide molecule
Preferred IUPAC name
CAS Number
693-13-0
JSmol
Interactive image
Beilstein Reference
ChEBI
CHEBI:53092
ChEMBL
ChEMBL1332992
ChemSpider
12211
ECHA InfoCard
100.010.677
Edit this at Wikidata
EC Number
Gmelin Reference
PubChem
12734
UNII
OQO20I6TWH
CompTox Dashboard
DTXSID4025086
Edit this at Wikidata
InChI
SMILES
Chemical formula
Molar mass

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