311:
202:
38:
482:
586:
Neu5Ac is also important in the biology of a number of pathogenic and symbiotic bacteria as it can be used either as a nutrient, providing both carbon and nitrogen to the bacteria, or in some pathogens, can be activated and placed on the cell surface. Bacteria have evolved transporters for Neu5Ac to
997:
139:
990:
983:
867:"Sialic acid transport in Haemophilus influenzae is essential for lipopolysaccharide sialylation and serum resistance and is dependent on a novel tripartite ATP-independent periplasmic transporter"
451:
495:
594:
360:
334:
InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/t5-,6+,7+,8+,9+,11+/m0/s1
344:
InChI=1/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/t5-,6+,7+,8+,9+,11+/m0/s1
1232:
1057:
622:
1203:
963:
325:
37:
587:
enable them to capture it from their environment and a number of these have been characterized including the NanT protein from
1164:
502:
1083:
268:
1249:
289:
235:
1098:
975:
639:
533:
1286:
1088:
229:
1237:
1007:
197:
599:
1276:
50:
1281:
609:
306:
105:
896:
865:
Severi E, Randle G, Kivlin P, Whitfield K, Young R, Moxon R, Kelly D, Hood D, Thomas GH (2005).
964:""ACENOBEL® Sustained Release Tablet 500 mg" Approved for Distal Myopathy with Rimmed Vacuoles"
945:
888:
847:
798:
749:
731:
692:
935:
927:
878:
837:
829:
818:"Identification of an inducible catabolic system for sialic acids (nan) in Escherichia coli"
788:
780:
739:
723:
682:
589:
383:
179:
277:
1208:
634:
604:
567:
710:
Vimr, Eric R.; Kalivoda, Kathryn A.; Deszo, Eric L.; Steenbergen, Susan M. (March 2004).
115:
310:
201:
159:
1243:
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1029:
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915:
473:
17:
842:
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435:
190:
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784:
727:
462:
457:
257:
833:
687:
670:
1149:
1131:
1111:
1052:
647:
621:
In Japan, Neu5Ac is approved under the trade name
Acenobel for the treatment of
552:
529:
539:
This residue is negatively charged at physiological pH and is found in complex
1172:
1154:
1126:
1121:
1116:
1106:
1047:
414:
170:
735:
1218:
1198:
571:
949:
892:
802:
753:
696:
916:"Identification of a novel sialic acid transporter in Haemophilus ducreyi"
851:
1193:
1065:
1020:
540:
244:
1039:
532:
found in human cells, and many mammalian cells. Other forms, such as
570:—mouth, nose, GI, respiratory tract), Neu5Ac acts as a receptor for
472:
Except where otherwise noted, data are given for materials in their
218:
563:
556:
544:
150:
138:
128:
209:
979:
294:
551:. Neu5Ac residues are also found in glycolipids, known as
555:, a crucial component of neuronal membranes found in the
767:
Vimr ER, Kalivoda KA, Deszo EL, Steenbergen SM (2004).
578:(an early step in acquiring influenzavirus infection).
490:
1181:
1163:
1140:
1097:
1074:
1038:
1019:
914:Post DM, Mungur R, Gibson BW, Munson RS Jr (2005).
440:186 °C (367 °F; 459 K) (decomposes)
574:viruses, allowing attachment to mucous cells via
562:Along with involvement in preventing infections (
671:"Sialic acid utilization by bacterial pathogens"
256:
769:"Diversity of microbial sialic acid metabolism"
712:"Diversity of Microbial Sialic Acid Metabolism"
114:
991:
8:
664:
662:
998:
984:
976:
716:Microbiology and Molecular Biology Reviews
309:
200:
178:
26:
939:
882:
841:
792:
743:
686:
276:
658:
365:
330:
305:
234:
191:
669:Severi E, Hood DW, Thomas GH (2007).
582:In the biology of bacterial pathogens
337:Key: SQVRNKJHWKZAKO-YRMXFSIDSA-N
158:
7:
623:distal myopathy with rimmed vacuoles
461:
368:OC(=O)1(O)C(O)(NC(C)=O)(O1)(O)(O)CO
347:Key: SQVRNKJHWKZAKO-YRMXFSIDBI
247:
217:
25:
1006:Other drugs for disorders of the
932:10.1128/IAI.73.10.6727-6735.2005
884:10.1111/j.1365-2958.2005.04901.x
480:
401:
395:
36:
547:and glycoproteins found at the
476:(at 25 °C , 100 kPa).
1165:Histone deacetylase inhibitors
785:10.1128/mmbr.68.1.132-153.2004
728:10.1128/MMBR.68.1.132-153.2004
404:
389:
1:
834:10.1128/jb.164.2.845-853.1985
1084:Delandistrogene moxeparvovec
54:5-(Acetylamino)-3,5-dideoxy-
688:10.1099/mic.0.2007/009480-0
536:, may also occur in cells.
1303:
1099:Antisense oligonucleotides
70:-non-2-ulopyranosonic acid
1227:
816:Vimr ER, Troy FA (1985).
534:N-Glycolylneuraminic acid
470:
444:
430:White crystalline powder
376:
356:
321:
98:
75:
49:
44:
35:
1089:Onasemnogene abeparvovec
1060:clostridium histolyticum
643:-Glycolylneuraminic acid
1008:musculo-skeletal system
236:N-Acetylneuraminic+Acid
31:-Acetylneuraminic acid
18:N-acetylneuraminic acid
773:Microbiol Mol Biol Rev
600:Haemophilus influenzae
518:-Acetylneuraminic acid
528:) is the predominant
610:Haemophilus ducreyi
422: g·mol
32:
1254:Never to phase III
503:Infobox references
27:
1264:
1263:
597:transporter from
511:Chemical compound
509:
508:
290:CompTox Dashboard
140:Interactive image
65:
57:
16:(Redirected from
1294:
1189:Aceneuramic acid
1000:
993:
986:
977:
971:
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968:
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954:
953:
943:
911:
905:
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877:(4): 1173–1185.
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796:
764:
758:
757:
747:
707:
701:
700:
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681:(9): 2817–2822.
666:
603:and the SatABCD
590:Escherichia coli
568:mucous membranes
566:associated with
493:
487:
484:
483:
465:
421:
406:
403:
397:
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384:Chemical formula
314:
313:
298:
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118:
87:Aceneuramic acid
63:
55:
40:
33:
21:
1302:
1301:
1297:
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1295:
1293:
1292:
1291:
1287:Monosaccharides
1267:
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1265:
1260:
1259:
1244:Clinical trials
1223:
1209:Hyaluronic acid
1177:
1159:
1142:Glucocorticoids
1136:
1093:
1070:
1034:
1023:and derivatives
1015:
1004:
974:
966:
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961:
957:
926:(10): 6727–35.
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815:
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766:
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635:Neuraminic acid
631:
619:
605:ABC transporter
584:
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498: ?)
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1076:Gene therapies
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871:Mol. Microbiol
857:
828:(2): 845–853.
808:
779:(1): 132–153.
759:
722:(1): 132–153.
702:
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637:
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474:standard state
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982:
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969:. Nobelpharm.
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612:
611:
606:
602:
601:
596:
593:, the SiaPQM
592:
591:
581:
579:
577:
576:hemagglutinin
573:
569:
565:
560:
558:
554:
550:
549:cell membrane
546:
542:
537:
535:
531:
527:
523:
519:
517:
504:
497:
492:
475:
469:
464:
459:
456:
453:
449:
448:
445:Pharmacology
443:
439:
437:
436:Melting point
434:
433:
429:
426:
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416:
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412:
388:
385:
381:
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375:
366:
362:
355:
341:
331:
327:
320:
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308:
307:DTXSID0050425
304:
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199:
196:
194:
192:ECHA InfoCard
189:
188:
181:
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69:
61:
52:
48:
43:
39:
34:
30:
19:
1277:Amino sugars
1214:Palovarotene
1204:Chondrocytes
1188:
1059:
1058:Collagenase
1030:Hydroquinine
958:
923:
920:Infect Immun
919:
909:
874:
870:
860:
825:
822:J. Bacteriol
821:
811:
776:
772:
762:
719:
715:
705:
678:
675:Microbiology
674:
640:
620:
608:
598:
588:
585:
561:
553:gangliosides
538:
525:
521:
515:
514:
513:
99:Identifiers
76:Other names
67:
59:
28:
1282:Sugar acids
1240:from market
1150:Deflazacort
1132:Viltolarsen
1112:Drisapersen
1053:Chymopapain
648:Sialic acid
617:Medical use
530:sialic acid
427:Appearance
377:Properties
198:100.004.568
160:CHEBI:61599
1271:Categories
1173:Givinostat
1155:Vamorolone
1127:Nusinersen
1122:Golodirsen
1117:Eteplirsen
1107:Casimersen
1048:Bromelains
654:References
415:Molar mass
278:GZP2782OP0
171:ChemSpider
127:3D model (
106:CAS Number
51:IUPAC name
1250:Phase III
1238:Withdrawn
1219:Risdiplam
1199:Branaplam
736:1092-2172
572:influenza
1194:Ataluren
950:16177350
901:32085592
893:16262798
803:15007099
754:15007099
697:17768226
629:See also
466:)
452:ATC code
116:131-48-6
90:Acenobel
1066:Trypsin
1040:Enzymes
1021:Quinine
941:1230923
852:3902799
541:glycans
496:what is
494: (
460: (
458:M09AX05
420:309.271
245:PubChem
68:galacto
60:glycero
1233:WHO-EM
948:
938:
899:
891:
850:
843:214328
840:
801:
794:362108
791:
752:
745:362108
742:
734:
695:
545:mucins
522:Neu5Ac
491:verify
488:
361:SMILES
258:439197
219:D11016
180:392681
84:Neu5Ac
45:Names
1182:Other
967:(PDF)
897:S2CID
607:from
564:mucus
557:brain
326:InChI
151:ChEBI
129:JSmol
946:PMID
889:PMID
848:PMID
799:PMID
750:PMID
732:ISSN
693:PMID
595:TRAP
526:NANA
269:UNII
230:MeSH
210:KEGG
81:NANA
1012:M09
936:PMC
928:doi
879:doi
838:PMC
830:doi
826:164
789:PMC
781:doi
740:PMC
724:doi
683:doi
679:153
543:on
524:or
463:WHO
295:EPA
248:CID
62:-α-
1273::
1246::
944:.
934:.
924:73
922:.
918:.
895:.
887:.
875:58
873:.
869:.
846:.
836:.
824:.
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797:.
787:.
777:68
775:.
771:.
748:.
738:.
730:.
720:68
718:.
714:.
691:.
677:.
673:.
661:^
625:.
613:.
559:.
399:19
393:11
1014:)
1010:(
999:e
992:t
985:v
952:.
930::
903:.
881::
854:.
832::
805:.
783::
756:.
726::
699:.
685::
641:N
520:(
516:N
486:Y
408:9
405:O
402:N
396:H
390:C
297:)
293:(
131:)
66:-
64:D
58:-
56:D
29:N
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
