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Baculoviridae

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Madeo, Marianna; Carrisi, Chiara; Iacopetta, Domenico; Capobianco, Loredana; Cappello, Anna Rita; Bucci, Cecilia; Palmieri, Ferdinando; Mazzeo, Giancarlo; Montalto, Anna (23 July 2009). "Abundant expression and purification of biologically active mitochondrial citrate carrier in baculovirus-infected
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It is produced in both early and late phases of the infection cycle with a maximal rate of synthesis occurring in 24–26 h after infection. Trimerization with intermolecular cysteine-bonds seems to be a crucial step for protein transport to cell surface, since only 33% of synthesized protein reaches
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When infecting a caterpillar, the advanced stages of infection cause the host to feed without resting, and then to climb to the higher parts of trees, including exposed places they would normally avoid due to the risk of predators. This is an advantage for the virus since (when the host dissolves)
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While BV is produced in the late phase, the ODV form is produced in the very late phase, acquiring the envelope from host cell nucleus and embedded in the matrix of occlusion body protein. These occlusion bodies are released when cells lyse to further spread baculovirus infection to next host. The
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Gp64 is essential for efficient budding of the virion and for the cell-to-cell transmission during the infection cycle, as well as viral entry, i.e. causing viral trophism and endosome-mediated uptake to the cell. The major function of the gp64 envelope protein is to cause the pH-mediated envelope
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BV acquires its envelope from the cell membrane and requires a glycoprotein, gp64, to be able to spread systemic infection. This protein forms structures called peplomers on one end of the budded virus particle, but is not found on ODVs (although several other proteins are only associated with the
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Baculoviruses are incapable of replicating within the cells of mammals and plants. They have a restricted range of hosts they can infect that is typically restricted to a limited number of closely related insect species. Because baculoviruses are not harmful to humans, they are considered a safe
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extensive lysis of cells frequently causes the host insect to literally disintegrate, thus the reason for the historic name "wilting disease". The complete ODV-polyhedrin particles are resistant to heat and light inactivation, whereas the naked BV virion is more sensitive to environment.
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Typically, the initial infection occurs when a susceptible host insect feeds on plants that are contaminated with the occluded form of the virus. The protein matrix dissolves in the alkaline environment of the host midgut (stomach), releasing ODVs that then fuse to the columnar
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Baculoviruses are known to infect insects, with over 600 host species having been described. Immature (larval) forms of lepidopteran species (moths and butterflies) are the most common hosts, but these viruses have also been found infecting
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with over 700 host species having been described. Immature (larval) forms of lepidopteran species are the most common hosts, but these viruses have also been found infecting sawflies and mosquitoes. Reports of baculovirus infections of
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ODV form). Some differences also exist in the lipid composition of the viral envelope of the two forms. While the BV envelope consists of phosphatidylserine, ODV contains phosphatidylcholine and phosphatidylethanolamine.
513:, successfully protecting against cervical cancer. Baculovirus-produced proteins are currently under study as therapeutic cancer vaccines with several immunologic advantages over proteins derived from mammalian sources. 967:
Lackner, A; Genta, K; Koppensteiner, H; Herbacek, I; Holzmann, K; Spiegl-Kreinecker, S; Berger, W; Grusch, M (2008). "A bicistronic baculovirus vector for transient and stable protein expression in mammalian cells".
481:(aa) with four glycosylation sites at asparagine residues and has a N-terminal signal sequence (20 aa), oligomerization and fusion domain and a hydrophobic transmembrane domain near the C-terminus (7 aa). 489:
fusion to the endosome. Although gp64 has variety of essential functions, it has been reported that gp64-null baculoviruses can be substituted with other viral glycoproteins such as Ld130, G-protein of
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and new BV particles are budded out from the basolateral side to spread the infection systemically. During budding, BV acquires a loosely fitting host cell membrane with expressed and displayed viral
1789: 1242:"Efficient generation of infectious recombinant baculoviruses by site-specific transposon-mediated insertion of foreign genes into a baculovirus genome propagated in Escherichia coli" 1362:
Ignoffo CM. (1975) Baculoviruses for Insect Pest Control: Safety Considerations, Summers M, Engler R, Falcon LA, Vail PV (eds.) American Society for Microbiology, Washington DC, p52
521:(commonly known as the spongy moth), a serious pest of forest trees, has been successfully contained by releasing spongy moth baculovirus (NPV) preparations. Certain species of 239:
larvae. Starting in the 1940s, the viruses were used and studied widely as biopesticides in crop fields. Since the 1990s, they have been employed to produce complex eukaryotic
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Baculovirus expression in insect cells represents a robust method for producing recombinant glycoproteins or membrane proteins. In the early 1990s, a system was developed by
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avian influenza in chickens was produced in a baculovirus expression vector). More recently, baculoviruses were found to transduce mammalian cells with a suitable promoter.
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Harrison, RL; Herniou, EA; Jehle, JA; Theilmann, DA; Burand, JP; Becnel, JJ; Krell, PJ; van Oers, MM; Mowery, JD; Bauchan, GR; Ictv Report, Consortium (September 2018).
1316:"Enhanced immune stimulation by a therapeutic lymphoma tumor antigen vaccine produced in insect cells involves mannose receptor targeting to antigen presenting cells" 5697: 1509:
Boucias, D. G.; Nordin, G. L. (1 July 1977). "Interinstar susceptibility of the fall webworm, Hyphantria cunea, to its nucleopolyhedrosis and granulosis viruses".
1782: 1637: 642: 5710: 550: 435:. The major capsid protein VP39 together with some minor proteins forms the nucleocapsid (21 nm x 260 nm) that encloses the DNA with p6.9 protein. 1749:
Index of Viruses – Baculoviridae (2006). In: ICTVdB – The Universal Virus Database, version 4. Büchen-Osmond, C (Ed), Columbia University, New York, USA.
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digestive system in order to replicate. It is possible for the virus crystals to enter human cells, but not to replicate to the point of causing illness.
1775: 5684: 466:(LdMNPV) is suggested to be an ancestral envelope fusion protein which has been replaced by non-orthologous gene replacement with gp64 in AcMNPV, 299:) and is responsible for the primary infection of the host, while the budded virus (BV) is released from the infected host cells later during the 1606: 1372:
Sait, S.M.; Begon, M.; Thompson, D.J. (1994). "The Effects of a Sublethal Baculovirus Infection in the Indian Meal Moth, Plodia interpunctella".
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The earliest records of baculoviruses can be found in the literature from as early as the 16th century in reports of "wilting disease" infecting
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During periods of evolution, the baculoviral envelope glycoproteins have undergone changes. Ld130, also known as baculovirus F-protein from
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Altmann, Friedrich; Staudacher, E; Wilson, IB; März, L (1999). "Insect cells as hosts for the expression of recombinant glycoproteins".
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Chiu E.; Coulibaly F.; Metcalf P. (April 2012). "Insect virus polyhedra, infectious protein crystals that contain virus particles".
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Jehle, JA; Blissard, GW; Bonning, BC; Cory, JS; Herniou, EA; Rohrmann, GF; Theilmann, DA; Thiem, SM; Vlak, JM; et al. (2006).
5776: 5723: 839: 197:. Although baculoviruses are capable of entering mammalian cells in culture, they are not known to be capable of replication in 1026:
Chiu, E; Coulibaly, F; Metcalf, P (2012). "Insect virus polyhedra, infectious protein crystals that contain virus particles".
545:—cosmopolitan insects that attack at least 30 food- and fibre-yielding crop plants—have been controlled by the application of 291:
The baculovirus lifecycle involves two distinct forms of virus. Occlusion-derived virus (ODV) is present in a protein matrix (
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Betting, David J.; Mu, Xi Y.; Kafi, Kamran; McDonnel, Desmond; Rosas, Francisco; Gold, Daniel P.; Timmerman, John M. (2009).
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of moths and butterflies to release the virus particle and infect the larva. An example of an insect that it infects is the
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The virus is unable to infect humans in the way it does insects, because human stomachs are acid-based and NPV requires an
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Gp64 is a homotrimeric membrane glycoprotein that is polarly present on the rod-shaped virion. It consists of 512
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Kost, T; Condreay, JP (1999). "Recombinant baculoviruses as expression vectors for insect and mammalian cells".
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in both human and veterinary medical treatments (for example, the most widely used vaccine for prevention of
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A nucleocapsid assembly-essential element (NAE) was identified in the AcMNPV genome. The NAE is an internal
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option for use in research applications. They are also used as biological agents as in the case of the
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Huang, Zhihong; Pan, Mengjia; Zhu, Silei; Zhang, Hao; Wu, Wenbi; Yuan, Meijin; Yang, Kai (2017).
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escape from the endosomes and are transported to nucleus. This step is possibly mediated by
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Hofmann, C.; Sandig, V.; Jennings, G.; Rudolph, M.; Schlag, P.; Strauss, M. (1995).
536:, etc.), have also been successfully controlled by NPV treatments specific to them. 408: 5650: 5542: 5487: 5422: 5391: 5358: 5208: 5180: 4998: 4970: 4949: 4935: 4928: 4918: 4754: 4688: 4617: 4465: 4435: 4424: 4371: 4327: 4317: 4298: 4274: 4225: 4137: 4050: 4008: 3847: 3779: 3757: 3737: 3727: 3537: 3453: 3364: 3335: 3323: 3313: 3301: 3291: 3269: 3227: 3217: 3190: 3169: 3147: 3123: 3113: 3091: 2988: 2939: 2900: 2886: 2865: 2634: 2612: 2590: 2457: 2359: 2347: 2304: 2293: 2200: 2189: 2154: 2060: 1912: 1767: 1448: 759: 691: 562: 353: 347: 343: 335: 307: 244: 209: 1417:"On the classification and nomenclature of baculoviruses: a proposal for revision" 1331: 43: 5630: 5408: 5187: 5173: 5086: 4942: 4732: 4645: 4638: 4581: 4487: 4408: 4291: 4208: 4174: 4100: 4062: 4043: 3979: 3972: 3803: 3663: 3352: 3180: 3080: 2975: 2825: 2807: 2783: 2646: 2624: 2450: 2428: 2396: 2337: 2126: 2038: 1900: 1850: 1826: 1756: 1665: 1416: 704: 509:. Baculovirus-produced proteins have been in use since 2007 as vaccines against 319:) were found to be nudiviruses, a closely related lineage to the baculoviruses. 275: 236: 174: 170: 95: 5280: 5236: 5130: 4891: 3700: 3690: 3442: 3042: 2369: 2119: 1727: 1487: 1432: 1202: 1123: 1039: 722: 684: 673: 478: 292: 202: 5621: 1265: 1210: 981: 913: 5671: 5476: 5347: 4881: 4837: 3911: 3588: 3560: 2999: 1839: 1811: 1570: 741: 541: 425: 388: 224: 166: 1675: 1589: 1544:
Theze, J.; Bezier, A.; Periquet, G.; Drezen, J.-M.; Herniou, E. A. (2011).
1495: 1440: 1349: 1298:"Cervarix : European Public Assessment Report – Scientific Discussion" 1218: 1174: 1131: 1096: 1047: 989: 821: 1283: 932: 5615: 1078: 812: 795: 683:
that protects the virus in the external environment. It dissolves in the
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NPV preparations have also been used commercially against pests such as
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https://ir.library.oregonstate.edu/concern/defaults/7d279043k?locale=en
889:"Efficient Gene Transfer into Human Hepatocytes by Baculovirus Vectors" 260: 240: 178: 726: 864:. International Committee on Taxonomy of Viruses (ICTV). March 2021. 747: 710: 687: 676: 522: 428: 312: 213: 198: 190: 5689: 5592: 1401: 5676: 380:
it can drip down onto leaves, which will be consumed by new hosts.
763: 407: 387: 352: 339: 282: 274: 162: 73: 1393: 595:, meaning "stick". The family has been divided into four genera: 264: 248: 5596: 5460: 5331: 4821: 3895: 3572: 2972: 1823: 1771: 861: 485:
cell surface, as monomeric gp64 is degraded within the cells.
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The name of this family has been derived from the Latin word
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virus. These substitutions will result in functional virons.
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filaments. Viral transcription and replication occur in the
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Baculoviruses have very species-specific tropisms among the
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Starting in the 1940s, they were used and studied widely as
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Rohrmann, G.F. 2019. Baculovirus Molecular Biology 4th Ed.
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Rohrmann, G.F. 2019. Baculovirus Molecular Biology 4th Ed.
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from which the virus gets its name is an extremely stable
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After baculovirus infection, three distinct phases occur:
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gene. The nucleocapsid assembly is not dependent on the
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Autographa californica multicapsid nucleopolyhedrovirus
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Luckow, V A; Lee, S C; Barry, G F; Olins, P O (1993).
653:, but the term now refers to 35 species of the family 1751:
https://www.ncbi.nlm.nih.gov/ICTVdb/Ictv/fs_index.htm
420:(AcMNPV). The virus was originally isolated from the 330:
of the host intestine and are taken into the cell in
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are placed in this family, assigned to four genera.
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(1986). 1546:"Paleozoic origin of insect large dsDNA viruses" 601:(lepidopteran-specific nucleopolyhedroviruses), 1550:Proceedings of the National Academy of Sciences 893:Proceedings of the National Academy of Sciences 643:International Committee on Taxonomy of Viruses 1783: 1757:https://www.ncbi.nlm.nih.gov/books/NBK543458/ 551:United States Environmental Protection Agency 8: 1667:Baculovirus Molecular Biology Fourth Edition 1616:(Fifth revised ed.). New Delhi, India. 796:"ICTV Virus Taxonomy Profile: Baculoviridae" 635:from 1993 until 2008, when it was abolished. 619:(dipteran-specific nucleopolyhedroviruses). 505:that allows for easy and fast generation of 566:(under the biotrol-VTN brand name) and the 259:proteins have been used in research and as 5593: 5515: 5504: 5493: 5482: 5471: 5457: 5386: 5375: 5364: 5353: 5342: 5328: 5324: 5265: 5108: 5071: 5027: 4913: 4876: 4865: 4854: 4843: 4832: 4818: 4717: 4482: 4471: 4430: 4393: 4356: 4269: 4258: 4203: 4159: 4122: 3950: 3939: 3928: 3917: 3906: 3892: 3774: 3763: 3722: 3685: 3627: 3616: 3605: 3594: 3583: 3569: 3565: 3470: 3459: 3448: 3396: 3264: 3253: 3212: 3175: 3164: 3153: 3108: 3097: 3086: 3027: 3016: 3005: 2994: 2983: 2969: 2778: 2767: 2708: 2697: 2686: 2575: 2538: 2501: 2490: 2391: 2332: 2321: 2310: 2299: 2228: 2217: 2206: 2195: 2055: 2044: 1989: 1978: 1967: 1956: 1878: 1867: 1856: 1845: 1834: 1820: 1816: 1790: 1776: 1768: 1636:: CS1 maint: location missing publisher ( 947:"Baculovirus - Baculovirus Lab Techniques" 42: 31: 1579: 1569: 1339: 1273: 1191:Journal of Bioenergetics and Biomembranes 1086: 922: 912: 811: 607:(lepidopteran-specific granuloviruses), 212:in crop fields. Baculoviruses contain a 181:, serve as natural hosts. Currently, 85 1005:"Mindsuckers – Meet Nature's Nightmare" 786: 1629: 766:including natural hosts of the viruses 223:(dsDNA) genome ranging from 80 to 180 51:Baculovirus virions and nucleocapsids 1455:from the original on 24 February 2023 7: 1670:(4th ed.). Bethesda, MD: NCBI. 570:(under the biotrol-VSE brand name). 424:(a lepidopteran) and contains a 134 1614:A textbook of biotechnology : 287:A dead caterpillar infected by NPV. 868:from the original on 20 March 2020 631:, which was a genus of the family 25: 1511:Journal of Invertebrate Pathology 412:Diagram of a Nucleopolyhedrovirus 1303:. European Medical Agency. 2007. 1155:Current Opinion in Biotechnology 725: 458:Major envelope glycoprotein gp64 416:The most studied baculovirus is 60: 1258:10.1128/jvi.67.8.4566-4579.1993 842:from the original on 2 May 2017 800:The Journal of General Virology 371:Very late phase (18–24 to 72 h) 169:, among the most studied being 1003:Zimmer, Carl (November 2014). 862:"Virus Taxonomy: 2020 Release" 511:human papillomavirus infection 1: 1332:10.1016/j.vaccine.2008.10.055 1167:10.1016/S0958-1669(99)00005-1 775:Polyhedrosis (disambiguation) 641:(NPV) was once listed by the 1685:The Biology of baculoviruses 1531:10.1016/0022-2011(77)90038-6 5793: 5762:Diptera pests and diseases 1706:. New York: Plenum Press. 639:Nuclear Polyhedrosis Virus 626: 623:Nuclear polyhedrosis virus 279:Diagram of a NPV lifecycle 18:Nuclear Polyhedrosis Virus 5470: 5456: 5341: 5327: 4831: 4817: 3905: 3891: 3582: 3568: 2982: 2968: 1833: 1819: 1687:. Boca Raton: CRC Press. 1664:Rohrmann, George (2019). 1488:10.1016/j.sbi.2012.02.003 1433:10.1007/s00705-006-0763-6 1374:Journal of Animal Ecology 1203:10.1007/s10863-009-9226-6 1040:10.1016/j.sbi.2012.02.003 507:recombinant baculoviruses 120: 115: 55: 50: 41: 34: 982:10.1016/j.ab.2008.05.020 914:10.1073/pnas.92.22.10099 627:Not to be confused with 5777:Mind-altering parasites 1571:10.1073/pnas.1105580108 1124:10.1023/A:1026488408951 970:Analytical Biochemistry 713: million years ago 404:Structure of the virion 1607:Viruses by J.Ogrodnick 1112:Glycoconjugate Journal 413: 393: 358: 288: 280: 5767:Insect viral diseases 1702:Miller, Lois (1997). 1612:Dubey, R. C. (2014). 1476:Curr Opin Struct Biol 1028:Curr Opin Struct Biol 547:Baculovirus heliothis 539:Members of the genus 411: 391: 356: 286: 278: 271:Baculovirus lifecycle 1803:virus classification 1079:10.1128/JVI.02110-16 813:10.1099/jgv.0.001107 770:Early 35 kDa protein 629:Nucleopolyhedrovirus 491:Vesicular stomatitis 472:Orgyia pseudotsugata 446:-element within the 231:Historical influence 57:Virus classification 4785:Permutotetraviridae 2544:Orthopolintovirales 2019:Malacoherpesviridae 1562:2011PNAS..10815931T 1523:1977JInvP..30...68B 1386:1994JAnEc..63..541S 1246:Journal of Virology 1067:Journal of Virology 1015:on 18 October 2014. 1009:National Geographic 905:1995PNAS...9210099H 899:(22): 10099–10103. 528:Neodiprion sertifer 433:open reading frames 301:secondary infection 3103:Malgrandaviricetes 2738:Sphaerolipoviridae 2724:Matshushitaviridae 2316:Nucleocytoviricota 708:family of viruses 667:gammabaculoviruses 659:alphabaculoviruses 534:, N. pratti pratti 414: 394: 359: 317:Oryctes rhinocerus 315:and beetles (e.g. 289: 281: 5739: 5738: 5599:Taxon identifiers 5590: 5589: 5586: 5585: 5582: 5581: 5578: 5577: 5574: 5573: 5570: 5569: 5566: 5565: 5562: 5561: 5452: 5451: 5448: 5447: 5444: 5443: 5440: 5439: 5436: 5435: 5432: 5431: 5314: 5313: 5310: 5309: 5306: 5305: 5302: 5301: 5298: 5297: 5294: 5293: 5290: 5289: 5260:Yunchangviricetes 5253: 5252: 5096: 5095: 5059: 5058: 5015: 5014: 4901: 4900: 4813: 4812: 4809: 4808: 4805: 4804: 4801: 4800: 4768: 4767: 4764: 4763: 4705: 4704: 4459: 4458: 4455: 4454: 4418: 4417: 4381: 4380: 4344: 4343: 4246: 4245: 4242: 4241: 4219:Carmotetraviridae 4191: 4190: 4147: 4146: 4110: 4109: 4094:Gammaflexiviridae 4087:Deltaflexiviridae 4073:Alphaflexiviridae 3966:Alphatetraviridae 3887: 3886: 3883: 3882: 3879: 3878: 3875: 3874: 3831: 3830: 3827: 3826: 3751: 3750: 3747: 3746: 3710: 3709: 3673: 3672: 3622:Chrymotiviricetes 3555: 3554: 3551: 3550: 3547: 3546: 3507: 3506: 3503: 3502: 3499: 3498: 3495: 3494: 3436: 3435: 3432: 3431: 3428: 3427: 3384: 3383: 3280:Bacilladnaviridae 3241: 3240: 3237: 3236: 3200: 3199: 3141: 3140: 3137: 3136: 3133: 3132: 3074: 3073: 3070: 3069: 3066: 3065: 2964: 2963: 2960: 2959: 2956: 2955: 2922:Portogloboviridae 2835: 2834: 2759: 2758: 2755: 2754: 2751: 2750: 2747: 2746: 2674: 2673: 2670: 2669: 2666: 2665: 2563: 2562: 2526: 2525: 2485:Preplasmiviricota 2478: 2477: 2474: 2473: 2379: 2378: 2287: 2286: 2283: 2282: 2279: 2278: 2275: 2274: 2183: 2182: 2179: 2178: 2175: 2174: 2171: 2170: 2078:Autographiviridae 2032: 2031: 2028: 2027: 2005:Alloherpesviridae 1944: 1943: 1940: 1939: 1936: 1935: 1932: 1931: 1713:978-0-306-45641-1 1704:The baculoviruses 1694:978-0-8493-5988-0 1623:978-81-219-2608-9 454:protein product. 154: 153: 27:Family of viruses 16:(Redirected from 5784: 5732: 5731: 5719: 5718: 5706: 5705: 5693: 5692: 5680: 5679: 5667: 5666: 5654: 5653: 5641: 5640: 5639: 5626: 5625: 5624: 5594: 5516: 5505: 5494: 5483: 5472: 5464:dsDNA-RT viruses 5458: 5387: 5376: 5365: 5354: 5343: 5335:ssRNA-RT viruses 5329: 5325: 5266: 5109: 5077:Serpentovirales 5072: 5050:Orthomyxoviridae 5028: 4978:Peribunyaviridae 4914: 4877: 4871:Chunqiuviricetes 4866: 4855: 4844: 4833: 4825:(–)ssRNA viruses 4819: 4718: 4561:Nanghoshaviridae 4483: 4472: 4446:Botourmiaviridae 4431: 4394: 4388:Howeltoviricetes 4357: 4351:Amabiliviricetes 4270: 4259: 4204: 4160: 4123: 4080:Betaflexiviridae 3951: 3940: 3929: 3918: 3907: 3899:(+)ssRNA viruses 3893: 3811:Picobirnaviridae 3775: 3769:Duplopiviricetes 3764: 3723: 3717:Vidaverviricetes 3686: 3680:Resentoviricetes 3650:Megabirnaviridae 3628: 3617: 3611:Duplornaviricota 3606: 3595: 3584: 3570: 3566: 3471: 3465:Huolimaviricetes 3460: 3449: 3397: 3391:Repensiviricetes 3265: 3254: 3248:Cressdnaviricota 3213: 3176: 3165: 3154: 3109: 3098: 3087: 3028: 3017: 3006: 2995: 2984: 2970: 2779: 2768: 2709: 2698: 2687: 2576: 2570:Tectiliviricetes 2539: 2533:Polintoviricetes 2507:Priklausovirales 2502: 2491: 2465:Marseilleviridae 2392: 2333: 2322: 2311: 2300: 2266:Papillomaviridae 2256:Zurhausenvirales 2229: 2218: 2207: 2196: 2071:Ackermannviridae 2056: 2045: 1990: 1979: 1968: 1957: 1923:Tristromaviridae 1894:Lipothrixviridae 1879: 1868: 1857: 1846: 1835: 1821: 1817: 1792: 1785: 1778: 1769: 1717: 1698: 1679: 1641: 1635: 1627: 1594: 1593: 1583: 1573: 1541: 1535: 1534: 1506: 1500: 1499: 1471: 1465: 1464: 1462: 1460: 1427:(7): 1257–1266. 1412: 1406: 1405: 1369: 1363: 1360: 1354: 1353: 1343: 1311: 1305: 1304: 1302: 1294: 1288: 1287: 1277: 1252:(8): 4566–4579. 1237: 1231: 1230: 1185: 1179: 1178: 1150: 1144: 1143: 1107: 1101: 1100: 1090: 1058: 1052: 1051: 1023: 1017: 1016: 1011:. Archived from 1000: 994: 993: 964: 958: 957: 955: 953: 943: 937: 936: 926: 916: 884: 878: 877: 875: 873: 858: 852: 851: 849: 847: 832: 826: 825: 815: 806:(9): 1185–1186. 791: 735: 730: 729: 714: 663:deltabaculovirus 616:Deltabaculovirus 610:Gammabaculovirus 598:Alphabaculovirus 518:Lymantria dispar 464:Lymantria dispar 384:Transmissibility 146:Gammabaculovirus 139:Deltabaculovirus 125:Alphabaculovirus 65: 64: 46: 32: 21: 5792: 5791: 5787: 5786: 5785: 5783: 5782: 5781: 5742: 5741: 5740: 5735: 5727: 5722: 5714: 5709: 5701: 5696: 5688: 5683: 5675: 5670: 5662: 5657: 5649: 5644: 5635: 5634: 5629: 5620: 5619: 5614: 5601: 5591: 5558: 5536: 5510:Revtraviricetes 5466: 5428: 5381:Revtraviricetes 5337: 5286: 5249: 5216:Paramyxoviridae 5164:Mononegavirales 5157: 5138:Crepuscuviridae 5092: 5055: 5033:Articulavirales 5022:Insthoviricetes 5011: 4897: 4860:Negarnaviricota 4827: 4797: 4760: 4738: 4712:Stelpaviricetes 4701: 4665: 4660:Polycipiviridae 4653:Dicistroviridae 4594: 4477:Pisoniviricetes 4451: 4414: 4377: 4340: 4311: 4238: 4198:Tolucaviricetes 4187: 4143: 4128:Amarillovirales 4106: 4056: 4016:Closteroviridae 3999:Martellivirales 3992: 3934:Kitrinoviricota 3901: 3871: 3855:Polymycoviridae 3823: 3743: 3706: 3669: 3578: 3543: 3531:Finnlakeviridae 3491: 3486:Pleolipoviridae 3424: 3380: 3358: 3329: 3307: 3285: 3233: 3207:Quintoviricetes 3196: 3129: 3062: 2978: 2952: 2831: 2813: 2743: 2714:Halopanivirales 2662: 2640: 2618: 2596: 2559: 2522: 2496:Maveriviricetes 2470: 2434: 2412: 2407:Phycodnaviridae 2375: 2353: 2327:Pokkesviricetes 2271: 2249: 2223:Papovaviricetes 2167: 2134:Rountreeviridae 2024: 1928: 1906: 1829: 1806: 1796: 1724: 1714: 1701: 1695: 1682: 1663: 1660: 1658:Further reading 1650:The Cobra Event 1645:Richard Preston 1628: 1624: 1611: 1603: 1601:General sources 1598: 1597: 1556:(38): 15931–5. 1543: 1542: 1538: 1508: 1507: 1503: 1473: 1472: 1468: 1458: 1456: 1414: 1413: 1409: 1371: 1370: 1366: 1361: 1357: 1313: 1312: 1308: 1300: 1296: 1295: 1291: 1239: 1238: 1234: 1189:insect cells". 1187: 1186: 1182: 1152: 1151: 1147: 1109: 1108: 1104: 1060: 1059: 1055: 1025: 1024: 1020: 1002: 1001: 997: 966: 965: 961: 951: 949: 945: 944: 940: 886: 885: 881: 871: 869: 860: 859: 855: 845: 843: 834: 833: 829: 793: 792: 788: 783: 754:The Cobra Event 731: 724: 721: 709: 700: 681:protein crystal 661:, but also one 651:Eubaculovirinae 636: 625: 604:Betabaculovirus 589: 581:Indian mealmoth 576: 568:cotton leafworm 553:registered the 549:. In 1975, the 499: 460: 406: 386: 325:epithelial cell 273: 253:High Five cells 233: 218:double-stranded 161:is a family of 132:Betabaculovirus 59: 28: 23: 22: 15: 12: 11: 5: 5790: 5788: 5780: 5779: 5774: 5772:Virus families 5769: 5764: 5759: 5754: 5744: 5743: 5737: 5736: 5734: 5733: 5720: 5707: 5694: 5681: 5668: 5655: 5642: 5627: 5611: 5609: 5603: 5602: 5597: 5588: 5587: 5584: 5583: 5580: 5579: 5576: 5575: 5572: 5571: 5568: 5567: 5564: 5563: 5560: 5559: 5557: 5556: 5553:Caulimoviridae 5548: 5546: 5538: 5537: 5535: 5534: 5531:Hepadnaviridae 5526: 5524: 5513: 5502: 5499:Artverviricota 5491: 5480: 5468: 5467: 5461: 5454: 5453: 5450: 5449: 5446: 5445: 5442: 5441: 5438: 5437: 5434: 5433: 5430: 5429: 5427: 5426: 5419: 5412: 5405: 5397: 5395: 5384: 5373: 5370:Artverviricota 5362: 5351: 5339: 5338: 5332: 5322: 5316: 5315: 5312: 5311: 5308: 5307: 5304: 5303: 5300: 5299: 5296: 5295: 5292: 5291: 5288: 5287: 5285: 5284: 5276: 5274: 5271:Goujianvirales 5263: 5255: 5254: 5251: 5250: 5248: 5247: 5240: 5233: 5226: 5219: 5212: 5205: 5198: 5191: 5184: 5177: 5169: 5167: 5159: 5158: 5156: 5155: 5148: 5141: 5134: 5127: 5119: 5117: 5114:Jingchuvirales 5106: 5103:Monjiviricetes 5098: 5097: 5094: 5093: 5091: 5090: 5082: 5080: 5069: 5066:Milneviricetes 5061: 5060: 5057: 5056: 5054: 5053: 5046: 5038: 5036: 5025: 5017: 5016: 5013: 5012: 5010: 5009: 5002: 4995: 4988: 4981: 4974: 4967: 4960: 4957:Leishbuviridae 4953: 4946: 4939: 4932: 4924: 4922: 4911: 4908:Ellioviricetes 4903: 4902: 4899: 4898: 4896: 4895: 4887: 4885: 4874: 4863: 4852: 4841: 4829: 4828: 4822: 4815: 4814: 4811: 4810: 4807: 4806: 4803: 4802: 4799: 4798: 4796: 4795: 4792:Sarthroviridae 4788: 4776: 4774: 4770: 4769: 4766: 4765: 4762: 4761: 4759: 4758: 4750: 4748: 4740: 4739: 4737: 4736: 4728: 4726: 4715: 4707: 4706: 4703: 4702: 4700: 4699: 4692: 4685: 4682:Alvernaviridae 4677: 4675: 4667: 4666: 4664: 4663: 4656: 4649: 4642: 4635: 4628: 4625:Solinviviridae 4621: 4614: 4611:Picornaviridae 4606: 4604: 4601:Picornavirales 4596: 4595: 4593: 4592: 4585: 4578: 4571: 4568:Nanhypoviridae 4564: 4557: 4550: 4543: 4540:Medioniviridae 4536: 4529: 4522: 4515: 4512:Cremegaviridae 4508: 4501: 4493: 4491: 4480: 4469: 4461: 4460: 4457: 4456: 4453: 4452: 4450: 4449: 4441: 4439: 4428: 4420: 4419: 4416: 4415: 4413: 4412: 4404: 4402: 4391: 4383: 4382: 4379: 4378: 4376: 4375: 4367: 4365: 4362:Wolframvirales 4354: 4346: 4345: 4342: 4341: 4339: 4338: 4331: 4323: 4321: 4313: 4312: 4310: 4309: 4302: 4295: 4288: 4280: 4278: 4267: 4256: 4248: 4247: 4244: 4243: 4240: 4239: 4237: 4236: 4229: 4222: 4214: 4212: 4201: 4193: 4192: 4189: 4188: 4186: 4185: 4182:Sinhaliviridae 4178: 4170: 4168: 4157: 4154:Magsaviricetes 4149: 4148: 4145: 4144: 4142: 4141: 4133: 4131: 4120: 4117:Flasuviricetes 4112: 4111: 4108: 4107: 4105: 4104: 4097: 4090: 4083: 4076: 4068: 4066: 4058: 4057: 4055: 4054: 4047: 4040: 4033: 4026: 4023:Endornaviridae 4019: 4012: 4004: 4002: 3994: 3993: 3991: 3990: 3983: 3976: 3969: 3961: 3959: 3948: 3937: 3926: 3915: 3903: 3902: 3896: 3889: 3888: 3885: 3884: 3881: 3880: 3877: 3876: 3873: 3872: 3870: 3869: 3866:Botybirnavirus 3858: 3851: 3839: 3837: 3833: 3832: 3829: 3828: 3825: 3824: 3822: 3821: 3818:Partitiviridae 3814: 3807: 3800: 3797:Curvulaviridae 3793: 3785: 3783: 3772: 3761: 3753: 3752: 3749: 3748: 3745: 3744: 3742: 3741: 3733: 3731: 3720: 3712: 3711: 3708: 3707: 3705: 3704: 3696: 3694: 3683: 3675: 3674: 3671: 3670: 3668: 3667: 3660: 3653: 3646: 3638: 3636: 3625: 3614: 3603: 3592: 3580: 3579: 3573: 3563: 3557: 3556: 3553: 3552: 3549: 3548: 3545: 3544: 3542: 3541: 3534: 3527: 3515: 3513: 3509: 3508: 3505: 3504: 3501: 3500: 3497: 3496: 3493: 3492: 3490: 3489: 3481: 3479: 3468: 3457: 3446: 3438: 3437: 3434: 3433: 3430: 3429: 3426: 3425: 3423: 3422: 3415: 3407: 3405: 3402:Geplafuvirales 3394: 3386: 3385: 3382: 3381: 3379: 3378: 3375:Redondoviridae 3370: 3368: 3360: 3359: 3357: 3356: 3349: 3341: 3339: 3331: 3330: 3328: 3327: 3319: 3317: 3309: 3308: 3306: 3305: 3297: 3295: 3287: 3286: 3284: 3283: 3275: 3273: 3262: 3251: 3243: 3242: 3239: 3238: 3235: 3234: 3232: 3231: 3223: 3221: 3210: 3202: 3201: 3198: 3197: 3195: 3194: 3186: 3184: 3173: 3162: 3151: 3143: 3142: 3139: 3138: 3135: 3134: 3131: 3130: 3128: 3127: 3119: 3117: 3106: 3095: 3084: 3076: 3075: 3072: 3071: 3068: 3067: 3064: 3063: 3061: 3060: 3057:Plectroviridae 3053: 3050:Paulinoviridae 3046: 3038: 3036: 3025: 3022:Faserviricetes 3014: 3011:Hofneiviricota 3003: 2992: 2980: 2979: 2973: 2966: 2965: 2962: 2961: 2958: 2957: 2954: 2953: 2951: 2950: 2943: 2932: 2925: 2918: 2915:Polydnaviridae 2911: 2904: 2897: 2890: 2883: 2880:Globuloviridae 2876: 2873:Fuselloviridae 2869: 2862: 2859:Bicaudaviridae 2855: 2852:Ampullaviridae 2843: 2841: 2837: 2836: 2833: 2832: 2830: 2829: 2821: 2819: 2815: 2814: 2812: 2811: 2804: 2801:Hytrosaviridae 2797: 2789: 2787: 2776: 2773:Naldaviricetes 2765: 2761: 2760: 2757: 2756: 2753: 2752: 2749: 2748: 2745: 2744: 2742: 2741: 2734: 2727: 2719: 2717: 2706: 2703:Laserviricetes 2695: 2692:Dividoviricota 2684: 2676: 2675: 2672: 2671: 2668: 2667: 2664: 2663: 2661: 2660: 2657:Corticoviridae 2652: 2650: 2642: 2641: 2639: 2638: 2630: 2628: 2620: 2619: 2617: 2616: 2608: 2606: 2598: 2597: 2595: 2594: 2586: 2584: 2573: 2565: 2564: 2561: 2560: 2558: 2557: 2549: 2547: 2536: 2528: 2527: 2524: 2523: 2521: 2520: 2512: 2510: 2499: 2488: 2480: 2479: 2476: 2475: 2472: 2471: 2469: 2468: 2461: 2454: 2446: 2444: 2441:Pimascovirales 2436: 2435: 2433: 2432: 2424: 2422: 2414: 2413: 2411: 2410: 2402: 2400: 2389: 2381: 2380: 2377: 2376: 2374: 2373: 2365: 2363: 2355: 2354: 2352: 2351: 2343: 2341: 2330: 2319: 2308: 2297: 2289: 2288: 2285: 2284: 2281: 2280: 2277: 2276: 2273: 2272: 2270: 2269: 2261: 2259: 2251: 2250: 2248: 2247: 2244:Polyomaviridae 2239: 2237: 2226: 2215: 2204: 2193: 2185: 2184: 2181: 2180: 2177: 2176: 2173: 2172: 2169: 2168: 2166: 2165: 2158: 2151: 2144: 2141:Salasmaviridae 2137: 2130: 2123: 2116: 2113:Herelleviridae 2109: 2102: 2099:Drexlerviridae 2095: 2092:Demerecviridae 2088: 2081: 2074: 2066: 2064: 2053: 2050:Caudoviricetes 2042: 2034: 2033: 2030: 2029: 2026: 2025: 2023: 2022: 2015: 2008: 2000: 1998: 1987: 1984:Herviviricetes 1976: 1965: 1962:Heunggongvirae 1954: 1946: 1945: 1942: 1941: 1938: 1937: 1934: 1933: 1930: 1929: 1927: 1926: 1918: 1916: 1908: 1907: 1905: 1904: 1897: 1889: 1887: 1884:Ligamenvirales 1876: 1865: 1854: 1843: 1831: 1830: 1824: 1814: 1808: 1807: 1797: 1795: 1794: 1787: 1780: 1772: 1766: 1765: 1759: 1753: 1747: 1736: 1723: 1722:External links 1720: 1719: 1718: 1712: 1699: 1693: 1680: 1659: 1656: 1655: 1654: 1642: 1622: 1609: 1602: 1599: 1596: 1595: 1536: 1501: 1466: 1407: 1380:(3): 541–550. 1364: 1355: 1306: 1289: 1232: 1197:(3): 289–297. 1180: 1145: 1102: 1053: 1018: 995: 959: 938: 879: 853: 827: 785: 784: 782: 779: 778: 777: 772: 767: 757: 750: 745: 737: 736: 733:Viruses portal 720: 717: 699: 696: 624: 621: 588: 585: 575: 572: 557:preparations. 498: 495: 459: 456: 422:alfalfa looper 405: 402: 385: 382: 373: 372: 369: 366: 365:Early (0–6 h), 272: 269: 232: 229: 205:animal cells. 152: 151: 150: 149: 142: 135: 128: 118: 117: 113: 112: 105: 101: 100: 93: 89: 88: 85:Naldaviricetes 81: 77: 76: 71: 67: 66: 53: 52: 48: 47: 39: 38: 26: 24: 14: 13: 10: 9: 6: 4: 3: 2: 5789: 5778: 5775: 5773: 5770: 5768: 5765: 5763: 5760: 5758: 5757:Biopesticides 5755: 5753: 5752:Baculoviridae 5750: 5749: 5747: 5730: 5725: 5721: 5717: 5712: 5708: 5704: 5699: 5695: 5691: 5686: 5682: 5678: 5673: 5669: 5665: 5660: 5656: 5652: 5647: 5643: 5638: 5637:Baculoviridae 5632: 5628: 5623: 5617: 5613: 5612: 5610: 5608: 5607:Baculoviridae 5604: 5600: 5595: 5555: 5554: 5550: 5549: 5547: 5545: 5544: 5539: 5533: 5532: 5528: 5527: 5525: 5523: 5522: 5521:Blubervirales 5517: 5514: 5512: 5511: 5506: 5503: 5501: 5500: 5495: 5492: 5490: 5489: 5484: 5481: 5479: 5478: 5473: 5469: 5465: 5459: 5455: 5425: 5424: 5420: 5418: 5417: 5416:Pseudoviridae 5413: 5411: 5410: 5406: 5404: 5403: 5402:Belpaoviridae 5399: 5398: 5396: 5394: 5393: 5388: 5385: 5383: 5382: 5377: 5374: 5372: 5371: 5366: 5363: 5361: 5360: 5355: 5352: 5350: 5349: 5344: 5340: 5336: 5330: 5326: 5323: 5321: 5317: 5283: 5282: 5278: 5277: 5275: 5273: 5272: 5267: 5264: 5262: 5261: 5256: 5246: 5245: 5241: 5239: 5238: 5234: 5232: 5231: 5230:Rhabdoviridae 5227: 5225: 5224: 5223:Pneumoviridae 5220: 5218: 5217: 5213: 5211: 5210: 5206: 5204: 5203: 5202:Mymonaviridae 5199: 5197: 5196: 5192: 5190: 5189: 5185: 5183: 5182: 5178: 5176: 5175: 5171: 5170: 5168: 5166: 5165: 5160: 5154: 5153: 5152:Natareviridae 5149: 5147: 5146: 5142: 5140: 5139: 5135: 5133: 5132: 5128: 5126: 5125: 5121: 5120: 5118: 5116: 5115: 5110: 5107: 5105: 5104: 5099: 5089: 5088: 5084: 5083: 5081: 5079: 5078: 5073: 5070: 5068: 5067: 5062: 5052: 5051: 5047: 5045: 5044: 5043:Amnoonviridae 5040: 5039: 5037: 5035: 5034: 5029: 5026: 5024: 5023: 5018: 5008: 5007: 5006:Wupedeviridae 5003: 5001: 5000: 4996: 4994: 4993: 4992:Phenuiviridae 4989: 4987: 4986: 4985:Phasmaviridae 4982: 4980: 4979: 4975: 4973: 4972: 4968: 4966: 4965: 4961: 4959: 4958: 4954: 4952: 4951: 4947: 4945: 4944: 4940: 4938: 4937: 4933: 4931: 4930: 4926: 4925: 4923: 4921: 4920: 4915: 4912: 4910: 4909: 4904: 4894: 4893: 4889: 4888: 4886: 4884: 4883: 4878: 4875: 4873: 4872: 4867: 4864: 4862: 4861: 4856: 4853: 4851: 4850: 4849:Orthornavirae 4845: 4842: 4840: 4839: 4834: 4830: 4826: 4820: 4816: 4794: 4793: 4789: 4787: 4786: 4781: 4778: 4777: 4775: 4771: 4757: 4756: 4752: 4751: 4749: 4747: 4746: 4745:Stellavirales 4741: 4735: 4734: 4730: 4729: 4727: 4725: 4724: 4723:Patatavirales 4719: 4716: 4714: 4713: 4708: 4698: 4697: 4696:Solemoviridae 4693: 4691: 4690: 4686: 4684: 4683: 4679: 4678: 4676: 4674: 4673: 4672:Sobelivirales 4668: 4662: 4661: 4657: 4655: 4654: 4650: 4648: 4647: 4643: 4641: 4640: 4636: 4634: 4633: 4632:Caliciviridae 4629: 4627: 4626: 4622: 4620: 4619: 4615: 4613: 4612: 4608: 4607: 4605: 4603: 4602: 4597: 4591: 4590: 4589:Tobaniviridae 4586: 4584: 4583: 4579: 4577: 4576: 4572: 4570: 4569: 4565: 4563: 4562: 4558: 4556: 4555: 4554:Mononiviridae 4551: 4549: 4548: 4547:Mesoniviridae 4544: 4542: 4541: 4537: 4535: 4534: 4533:Gresnaviridae 4530: 4528: 4527: 4526:Euroniviridae 4523: 4521: 4520: 4519:Coronaviridae 4516: 4514: 4513: 4509: 4507: 4506: 4505:Arteriviridae 4502: 4500: 4499: 4498:Abyssoviridae 4495: 4494: 4492: 4490: 4489: 4484: 4481: 4479: 4478: 4473: 4470: 4468: 4467: 4462: 4448: 4447: 4443: 4442: 4440: 4438: 4437: 4432: 4429: 4427: 4426: 4421: 4411: 4410: 4406: 4405: 4403: 4401: 4400: 4399:Cryppavirales 4395: 4392: 4390: 4389: 4384: 4374: 4373: 4369: 4368: 4366: 4364: 4363: 4358: 4355: 4353: 4352: 4347: 4337: 4336: 4335:Steitzviridae 4332: 4330: 4329: 4325: 4324: 4322: 4320: 4319: 4314: 4308: 4307: 4306:Solspiviridae 4303: 4301: 4300: 4296: 4294: 4293: 4289: 4287: 4286: 4285:Atkinsviridae 4282: 4281: 4279: 4277: 4276: 4271: 4268: 4266: 4265: 4264:Leviviricetes 4260: 4257: 4255: 4254: 4253:Lenarviricota 4249: 4235: 4234: 4233:Tombusviridae 4230: 4228: 4227: 4223: 4221: 4220: 4216: 4215: 4213: 4211: 4210: 4205: 4202: 4200: 4199: 4194: 4184: 4183: 4179: 4177: 4176: 4172: 4171: 4169: 4167: 4166: 4165:Nodamuvirales 4161: 4158: 4156: 4155: 4150: 4140: 4139: 4135: 4134: 4132: 4130: 4129: 4124: 4121: 4119: 4118: 4113: 4103: 4102: 4098: 4096: 4095: 4091: 4089: 4088: 4084: 4082: 4081: 4077: 4075: 4074: 4070: 4069: 4067: 4065: 4064: 4059: 4053: 4052: 4048: 4046: 4045: 4041: 4039: 4038: 4034: 4032: 4031: 4027: 4025: 4024: 4020: 4018: 4017: 4013: 4011: 4010: 4006: 4005: 4003: 4001: 4000: 3995: 3989: 3988: 3987:Matonaviridae 3984: 3982: 3981: 3977: 3975: 3974: 3970: 3968: 3967: 3963: 3962: 3960: 3958: 3957: 3956:Hepelivirales 3952: 3949: 3947: 3946: 3945:Alsuviricetes 3941: 3938: 3936: 3935: 3930: 3927: 3925: 3924: 3923:Orthornavirae 3919: 3916: 3914: 3913: 3908: 3904: 3900: 3894: 3890: 3868: 3867: 3862: 3859: 3857: 3856: 3852: 3850: 3849: 3844: 3841: 3840: 3838: 3834: 3820: 3819: 3815: 3813: 3812: 3808: 3806: 3805: 3801: 3799: 3798: 3794: 3792: 3791: 3790:Amalgaviridae 3787: 3786: 3784: 3782: 3781: 3776: 3773: 3771: 3770: 3765: 3762: 3760: 3759: 3754: 3740: 3739: 3735: 3734: 3732: 3730: 3729: 3724: 3721: 3719: 3718: 3713: 3703: 3702: 3698: 3697: 3695: 3693: 3692: 3687: 3684: 3682: 3681: 3676: 3666: 3665: 3661: 3659: 3658: 3657:Quadriviridae 3654: 3652: 3651: 3647: 3645: 3644: 3643:Chrysoviridae 3640: 3639: 3637: 3635: 3634: 3633:Ghabrivirales 3629: 3626: 3624: 3623: 3618: 3615: 3613: 3612: 3607: 3604: 3602: 3601: 3600:Orthornavirae 3596: 3593: 3591: 3590: 3585: 3581: 3577: 3576:dsRNA viruses 3571: 3567: 3564: 3562: 3558: 3540: 3539: 3535: 3533: 3532: 3528: 3526: 3525: 3524:Anelloviridae 3520: 3517: 3516: 3514: 3510: 3488: 3487: 3483: 3482: 3480: 3478: 3477: 3476:Haloruvirales 3472: 3469: 3467: 3466: 3461: 3458: 3456: 3455: 3450: 3447: 3445: 3444: 3439: 3421: 3420: 3419:Genomoviridae 3416: 3414: 3413: 3412:Geminiviridae 3409: 3408: 3406: 3404: 3403: 3398: 3395: 3393: 3392: 3387: 3377: 3376: 3372: 3371: 3369: 3367: 3366: 3361: 3355: 3354: 3350: 3348: 3347: 3346:Metaxyviridae 3343: 3342: 3340: 3338: 3337: 3332: 3326: 3325: 3321: 3320: 3318: 3316: 3315: 3310: 3304: 3303: 3299: 3298: 3296: 3294: 3293: 3288: 3282: 3281: 3277: 3276: 3274: 3272: 3271: 3266: 3263: 3261: 3260: 3259:Arfiviricetes 3255: 3252: 3250: 3249: 3244: 3230: 3229: 3225: 3224: 3222: 3220: 3219: 3214: 3211: 3209: 3208: 3203: 3193: 3192: 3188: 3187: 3185: 3183: 3182: 3177: 3174: 3172: 3171: 3166: 3163: 3161: 3160: 3159:Cossaviricota 3155: 3152: 3150: 3149: 3144: 3126: 3125: 3121: 3120: 3118: 3116: 3115: 3110: 3107: 3105: 3104: 3099: 3096: 3094: 3093: 3088: 3085: 3083: 3082: 3077: 3059: 3058: 3054: 3052: 3051: 3047: 3045: 3044: 3040: 3039: 3037: 3035: 3034: 3033:Tubulavirales 3029: 3026: 3024: 3023: 3018: 3015: 3013: 3012: 3007: 3004: 3002: 3001: 2996: 2993: 2991: 2990: 2985: 2981: 2977: 2976:ssDNA viruses 2971: 2967: 2949: 2948: 2947:Rhizidiovirus 2944: 2942: 2941: 2936: 2933: 2931: 2930: 2929:Thaspiviridae 2926: 2924: 2923: 2919: 2917: 2916: 2912: 2910: 2909: 2908:Plasmaviridae 2905: 2903: 2902: 2898: 2896: 2895: 2894:Halspiviridae 2891: 2889: 2888: 2884: 2882: 2881: 2877: 2875: 2874: 2870: 2868: 2867: 2863: 2861: 2860: 2856: 2854: 2853: 2848: 2845: 2844: 2842: 2838: 2828: 2827: 2823: 2822: 2820: 2816: 2810: 2809: 2805: 2803: 2802: 2798: 2796: 2795: 2794:Baculoviridae 2791: 2790: 2788: 2786: 2785: 2780: 2777: 2775: 2774: 2769: 2766: 2762: 2740: 2739: 2735: 2733: 2732: 2731:Simuloviridae 2728: 2726: 2725: 2721: 2720: 2718: 2716: 2715: 2710: 2707: 2705: 2704: 2699: 2696: 2694: 2693: 2688: 2685: 2683: 2682: 2681:Helvetiavirae 2677: 2659: 2658: 2654: 2653: 2651: 2649: 2648: 2643: 2637: 2636: 2632: 2631: 2629: 2627: 2626: 2621: 2615: 2614: 2610: 2609: 2607: 2605: 2604: 2603:Kalamavirales 2599: 2593: 2592: 2588: 2587: 2585: 2583: 2582: 2581:Belfryvirales 2577: 2574: 2572: 2571: 2566: 2556: 2555: 2554:Adintoviridae 2551: 2550: 2548: 2546: 2545: 2540: 2537: 2535: 2534: 2529: 2519: 2518: 2517:Lavidaviridae 2514: 2513: 2511: 2509: 2508: 2503: 2500: 2498: 2497: 2492: 2489: 2487: 2486: 2481: 2467: 2466: 2462: 2460: 2459: 2455: 2453: 2452: 2448: 2447: 2445: 2443: 2442: 2437: 2431: 2430: 2426: 2425: 2423: 2421: 2420: 2419:Imitervirales 2415: 2409: 2408: 2404: 2403: 2401: 2399: 2398: 2393: 2390: 2388: 2387: 2386:Megaviricetes 2382: 2372: 2371: 2367: 2366: 2364: 2362: 2361: 2356: 2350: 2349: 2345: 2344: 2342: 2340: 2339: 2334: 2331: 2329: 2328: 2323: 2320: 2318: 2317: 2312: 2309: 2307: 2306: 2301: 2298: 2296: 2295: 2290: 2268: 2267: 2263: 2262: 2260: 2258: 2257: 2252: 2246: 2245: 2241: 2240: 2238: 2236: 2235: 2234:Sepolyvirales 2230: 2227: 2225: 2224: 2219: 2216: 2214: 2213: 2212:Cossaviricota 2208: 2205: 2203: 2202: 2197: 2194: 2192: 2191: 2186: 2164: 2163: 2162:Zobellviridae 2159: 2157: 2156: 2152: 2150: 2149: 2148:Schitoviridae 2145: 2143: 2142: 2138: 2136: 2135: 2131: 2129: 2128: 2124: 2122: 2121: 2117: 2115: 2114: 2110: 2108: 2107: 2106:Guelinviridae 2103: 2101: 2100: 2096: 2094: 2093: 2089: 2087: 2086: 2082: 2080: 2079: 2075: 2073: 2072: 2068: 2067: 2065: 2063: 2062: 2057: 2054: 2052: 2051: 2046: 2043: 2041: 2040: 2035: 2021: 2020: 2016: 2014: 2013: 2012:Herpesviridae 2009: 2007: 2006: 2002: 2001: 1999: 1997: 1996: 1995:Herpesvirales 1991: 1988: 1986: 1985: 1980: 1977: 1975: 1974: 1973:Peploviricota 1969: 1966: 1964: 1963: 1958: 1955: 1953: 1952: 1951:Duplodnaviria 1947: 1925: 1924: 1920: 1919: 1917: 1915: 1914: 1909: 1903: 1902: 1898: 1896: 1895: 1891: 1890: 1888: 1886: 1885: 1880: 1877: 1875: 1874: 1873:Tokiviricetes 1869: 1866: 1864: 1863: 1862:Taleaviricota 1858: 1855: 1853: 1852: 1847: 1844: 1842: 1841: 1836: 1832: 1828: 1827:dsDNA viruses 1822: 1818: 1815: 1813: 1809: 1804: 1800: 1793: 1788: 1786: 1781: 1779: 1774: 1773: 1770: 1764: 1760: 1758: 1754: 1752: 1748: 1746: 1745: 1744:Baculoviridae 1741: 1737: 1735: 1734: 1733:Baculoviridae 1730: 1726: 1725: 1721: 1715: 1709: 1705: 1700: 1696: 1690: 1686: 1681: 1677: 1673: 1669: 1668: 1662: 1661: 1657: 1652: 1651: 1646: 1643: 1639: 1633: 1625: 1619: 1615: 1610: 1608: 1605: 1604: 1600: 1591: 1587: 1582: 1577: 1572: 1567: 1563: 1559: 1555: 1551: 1547: 1540: 1537: 1532: 1528: 1524: 1520: 1516: 1512: 1505: 1502: 1497: 1493: 1489: 1485: 1482:(2): 234–40. 1481: 1477: 1470: 1467: 1454: 1450: 1446: 1442: 1438: 1434: 1430: 1426: 1422: 1418: 1411: 1408: 1403: 1399: 1395: 1391: 1387: 1383: 1379: 1375: 1368: 1365: 1359: 1356: 1351: 1347: 1342: 1337: 1333: 1329: 1325: 1321: 1317: 1310: 1307: 1299: 1293: 1290: 1285: 1281: 1276: 1271: 1267: 1263: 1259: 1255: 1251: 1247: 1243: 1236: 1233: 1228: 1224: 1220: 1216: 1212: 1208: 1204: 1200: 1196: 1192: 1184: 1181: 1176: 1172: 1168: 1164: 1161:(5): 428–33. 1160: 1156: 1149: 1146: 1141: 1137: 1133: 1129: 1125: 1121: 1118:(2): 109–23. 1117: 1113: 1106: 1103: 1098: 1094: 1089: 1084: 1080: 1076: 1072: 1068: 1064: 1057: 1054: 1049: 1045: 1041: 1037: 1034:(2): 234–40. 1033: 1029: 1022: 1019: 1014: 1010: 1006: 999: 996: 991: 987: 983: 979: 975: 971: 963: 960: 948: 942: 939: 934: 930: 925: 920: 915: 910: 906: 902: 898: 894: 890: 883: 880: 867: 863: 857: 854: 841: 837: 831: 828: 823: 819: 814: 809: 805: 801: 797: 790: 787: 780: 776: 773: 771: 768: 765: 761: 758: 756: 755: 751: 749: 746: 744: 743: 739: 738: 734: 728: 723: 718: 716: 712: 707: 706: 697: 695: 693: 689: 686: 682: 678: 675: 670: 668: 664: 660: 656: 655:Baculoviridae 652: 648: 644: 640: 634: 633:Baculoviridae 630: 622: 620: 618: 617: 612: 611: 606: 605: 600: 599: 594: 586: 584: 582: 573: 571: 569: 565: 564: 558: 556: 552: 548: 544: 543: 537: 535: 533: 529: 524: 520: 519: 514: 512: 508: 504: 496: 494: 492: 486: 482: 480: 475: 473: 469: 465: 457: 455: 453: 449: 445: 440: 436: 434: 430: 427: 423: 419: 410: 403: 401: 399: 390: 383: 381: 377: 370: 368:Late (6–24 h) 367: 364: 363: 362: 355: 351: 349: 348:glycoproteins 345: 341: 337: 336:Nucleocapsids 333: 329: 326: 320: 318: 314: 309: 308:invertebrates 304: 302: 298: 294: 285: 277: 270: 268: 266: 262: 258: 254: 250: 246: 245:cell cultures 242: 238: 230: 228: 226: 222: 219: 215: 211: 210:biopesticides 206: 204: 200: 196: 192: 186: 184: 180: 176: 172: 168: 164: 160: 159: 158:Baculoviridae 148: 147: 143: 141: 140: 136: 134: 133: 129: 127: 126: 122: 121: 119: 114: 111: 110: 109:Baculoviridae 106: 103: 102: 99: 98: 94: 91: 90: 87: 86: 82: 79: 78: 75: 72: 69: 68: 63: 58: 54: 49: 45: 40: 37: 36:Baculoviridae 33: 30: 19: 5606: 5551: 5543:Ortervirales 5541: 5529: 5519: 5508: 5497: 5488:Pararnavirae 5486: 5475: 5423:Retroviridae 5421: 5414: 5407: 5400: 5392:Ortervirales 5390: 5379: 5368: 5359:Pararnavirae 5357: 5346: 5279: 5269: 5258: 5244:Xinmoviridae 5242: 5235: 5228: 5221: 5214: 5209:Nyamiviridae 5207: 5200: 5195:Lispiviridae 5193: 5186: 5181:Bornaviridae 5179: 5172: 5162: 5150: 5145:Myriaviridae 5143: 5136: 5129: 5124:Aliusviridae 5122: 5112: 5101: 5085: 5075: 5064: 5048: 5041: 5031: 5020: 5004: 4999:Tospoviridae 4997: 4990: 4983: 4976: 4971:Nairoviridae 4969: 4962: 4955: 4950:Hantaviridae 4948: 4941: 4936:Arenaviridae 4934: 4929:Cruliviridae 4927: 4919:Bunyavirales 4917: 4906: 4890: 4880: 4869: 4858: 4847: 4836: 4790: 4783: 4779: 4755:Astroviridae 4753: 4743: 4731: 4721: 4710: 4694: 4689:Barnaviridae 4687: 4680: 4670: 4658: 4651: 4644: 4637: 4630: 4623: 4618:Marnaviridae 4616: 4609: 4599: 4587: 4580: 4575:Olifoviridae 4573: 4566: 4559: 4552: 4545: 4538: 4531: 4524: 4517: 4510: 4503: 4496: 4486: 4475: 4466:Pisuviricota 4464: 4444: 4436:Ourlivirales 4434: 4425:Miaviricetes 4423: 4407: 4397: 4386: 4372:Narnaviridae 4370: 4360: 4349: 4333: 4328:Blumeviridae 4326: 4318:Timlovirales 4316: 4304: 4299:Fiersviridae 4297: 4290: 4283: 4275:Norzivirales 4273: 4262: 4251: 4231: 4226:Luteoviridae 4224: 4217: 4207: 4196: 4180: 4173: 4163: 4152: 4138:Flaviviridae 4136: 4126: 4115: 4099: 4092: 4085: 4078: 4071: 4061: 4051:Virgaviridae 4049: 4042: 4035: 4028: 4021: 4014: 4009:Bromoviridae 4007: 3997: 3985: 3978: 3971: 3964: 3954: 3943: 3932: 3921: 3910: 3864: 3860: 3853: 3848:Birnaviridae 3846: 3842: 3816: 3809: 3802: 3795: 3788: 3780:Durnavirales 3778: 3767: 3758:Pisuviricota 3756: 3738:Cystoviridae 3736: 3728:Mindivirales 3726: 3715: 3699: 3689: 3678: 3662: 3655: 3648: 3641: 3631: 3620: 3609: 3598: 3587: 3538:Spiraviridae 3536: 3529: 3522: 3518: 3484: 3474: 3463: 3454:Saleviricota 3452: 3441: 3417: 3410: 3400: 3389: 3373: 3365:Recrevirales 3363: 3351: 3344: 3336:Mulpavirales 3334: 3324:Smacoviridae 3322: 3314:Cremevirales 3312: 3302:Circoviridae 3300: 3292:Cirlivirales 3290: 3278: 3270:Baphyvirales 3268: 3257: 3246: 3228:Parvoviridae 3226: 3218:Piccovirales 3216: 3205: 3191:Bidnaviridae 3189: 3179: 3170:Mouviricetes 3168: 3157: 3148:Shotokuvirae 3146: 3124:Microviridae 3122: 3114:Petitvirales 3112: 3101: 3092:Phixviricota 3090: 3079: 3055: 3048: 3041: 3031: 3020: 3009: 2998: 2989:Monodnaviria 2987: 2945: 2940:Dinodnavirus 2938: 2934: 2927: 2920: 2913: 2906: 2901:Ovaliviridae 2899: 2892: 2887:Guttaviridae 2885: 2878: 2871: 2866:Clavaviridae 2864: 2857: 2850: 2846: 2824: 2806: 2799: 2793: 2792: 2782: 2771: 2736: 2729: 2722: 2712: 2701: 2690: 2679: 2655: 2645: 2635:Adenoviridae 2633: 2623: 2613:Tectiviridae 2611: 2601: 2591:Turriviridae 2589: 2579: 2568: 2552: 2542: 2531: 2515: 2505: 2494: 2483: 2463: 2458:Iridoviridae 2456: 2449: 2439: 2427: 2417: 2405: 2395: 2384: 2368: 2360:Chitovirales 2358: 2348:Asfarviridae 2346: 2336: 2325: 2314: 2305:Bamfordvirae 2303: 2294:Varidnaviria 2292: 2264: 2254: 2242: 2232: 2221: 2210: 2201:Shotokuvirae 2199: 2190:Monodnaviria 2188: 2160: 2155:Siphoviridae 2153: 2146: 2139: 2132: 2125: 2118: 2111: 2104: 2097: 2090: 2085:Chaseviridae 2083: 2076: 2069: 2061:Caudovirales 2059: 2048: 2037: 2017: 2010: 2003: 1993: 1982: 1971: 1960: 1949: 1921: 1913:Primavirales 1911: 1899: 1892: 1882: 1871: 1860: 1849: 1838: 1743: 1739: 1732: 1728: 1703: 1684: 1666: 1648: 1613: 1553: 1549: 1539: 1517:(1): 68–75. 1514: 1510: 1504: 1479: 1475: 1469: 1457:. 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Retrieved 836:"Viral Zone" 830: 803: 799: 789: 760:Pancrustacea 752: 740: 703: 701: 692:fall webworm 671: 654: 650: 638: 637: 632: 614: 608: 602: 596: 592: 590: 577: 563:Trichoplusia 561: 559: 555:B. heliothis 554: 546: 540: 538: 526: 516: 515: 500: 497:Applications 490: 487: 483: 476: 471: 470:(BmNPV) and 467: 463: 461: 451: 447: 443: 441: 437: 417: 415: 395: 378: 374: 360: 344:cell nucleus 321: 316: 305: 290: 234: 207: 187: 157: 156: 155: 144: 137: 130: 123: 108: 107: 96: 84: 70:(unranked): 35: 29: 5631:Wikispecies 5409:Metaviridae 5188:Filoviridae 5174:Artoviridae 5087:Aspiviridae 4964:Mypoviridae 4943:Fimoviridae 4733:Potyviridae 4646:Secoviridae 4639:Iflaviridae 4582:Roniviridae 4488:Nidovirales 4409:Mitoviridae 4292:Duinviridae 4209:Tolivirales 4175:Nodaviridae 4101:Tymoviridae 4063:Tymovirales 4044:Togaviridae 4037:Mayoviridae 4030:Kitaviridae 3980:Hepeviridae 3973:Benyviridae 3804:Hypoviridae 3664:Totiviridae 3353:Nanoviridae 3181:Polivirales 3081:Sangervirae 2826:Nimaviridae 2808:Nudiviridae 2784:Lefavirales 2647:Vinavirales 2625:Rowavirales 2451:Ascoviridae 2429:Mimiviridae 2397:Algavirales 2338:Asfuvirales 2127:Podoviridae 2039:Uroviricota 1901:Rudiviridae 1851:Zilligvirae 1729:ICTV Report 705:Nudiviridae 532:N. lecontei 479:amino acids 468:Bombyx mori 257:recombinant 175:Hymenoptera 171:Lepidoptera 97:Lefavirales 5746:Categories 5281:Yueviridae 5237:Sunviridae 5131:Chuviridae 4892:Qinviridae 4773:Unassigned 3836:Unassigned 3701:Reoviridae 3691:Reovirales 3512:Unassigned 3443:Trapavirae 3043:Inoviridae 2840:Unassigned 2818:Unassigned 2764:Unassigned 2370:Poxviridae 2120:Myoviridae 1459:1 February 1421:Arch Virol 838:. ExPASy. 781:References 674:polyhedral 293:polyhedrin 243:in insect 203:vertebrate 195:mosquitoes 167:Arthropods 5477:Riboviria 5348:Riboviria 4882:Muvirales 4838:Riboviria 3912:Riboviria 3589:Riboviria 3000:Loebvirae 1840:Adnaviria 1799:Baltimore 1740:Viralzone 1632:cite book 1266:0022-538X 1211:0145-479X 952:16 August 742:Cypovirus 698:Evolution 657:, mostly 574:Biosafety 542:Heliothis 431:with 154 332:endosomes 328:membranes 255:). These 201:or other 199:mammalian 5616:Wikidata 4780:Families 3843:Families 3519:Families 2847:Families 1676:31294936 1647:(1998). 1590:21911395 1496:22475077 1453:Archived 1441:16648963 1350:19000731 1227:44943721 1219:19629661 1175:10508635 1140:34863069 1132:10612411 1097:28031366 1048:22475077 990:18541133 866:Archived 840:Archived 822:29947603 719:See also 685:alkaline 665:and two 647:subgenus 587:Taxonomy 503:Monsanto 398:alkaline 297:granulin 261:vaccines 241:proteins 237:silkworm 214:circular 191:sawflies 104:Family: 5622:Q763221 1581:3179036 1558:Bibcode 1519:Bibcode 1449:6293565 1382:Bibcode 1341:2683685 1320:Vaccine 1284:8392598 1088:5309959 933:7479733 901:Bibcode 846:15 June 593:baculus 183:species 179:Diptera 163:viruses 116:Genera 92:Order: 80:Class: 5729:600016 5703:106840 5677:1BACUF 3861:Genera 2935:Genera 1710:  1691:  1674:  1620:  1588:  1578:  1494:  1447:  1439:  1400:  1348:  1338:  1282:  1275:237841 1272:  1264:  1225:  1217:  1209:  1173:  1138:  1130:  1095:  1085:  1046:  988:  931:  921:  872:12 May 820:  748:BacMam 688:midgut 677:capsid 523:sawfly 429:genome 313:shrimp 193:, and 5724:WoRMS 5716:10442 5698:IRMNG 5651:6235K 5462:VII: 3574:III: 1445:S2CID 1398:JSTOR 1301:(PDF) 1223:S2CID 1136:S2CID 1073:(5). 924:40743 764:clade 645:as a 340:actin 247:(see 74:Virus 5711:NCBI 5690:1925 5685:GBIF 5672:EPPO 5664:5041 5333:VI: 3897:IV: 2974:II: 1708:ISBN 1689:ISBN 1672:PMID 1638:link 1618:ISBN 1586:PMID 1492:PMID 1461:2019 1437:PMID 1402:5220 1346:PMID 1280:PMID 1262:ISSN 1215:PMID 1207:ISSN 1171:PMID 1128:PMID 1093:PMID 1044:PMID 986:PMID 954:2024 929:PMID 874:2021 848:2015 818:PMID 672:The 452:ac83 448:ac83 265:H5N1 249:Sf21 177:and 5659:EoL 5646:CoL 4823:V: 3561:RNA 1825:I: 1812:DNA 1576:PMC 1566:doi 1554:108 1527:doi 1484:doi 1429:doi 1425:151 1390:doi 1336:PMC 1328:doi 1270:PMC 1254:doi 1199:doi 1163:doi 1120:doi 1083:PMC 1075:doi 1036:doi 978:doi 974:380 919:PMC 909:doi 808:doi 711:310 649:of 444:cis 426:kbp 295:or 225:kbp 221:DNA 5748:: 5726:: 5713:: 5700:: 5687:: 5674:: 5661:: 5648:: 5633:: 5618:: 5320:RT 4782:: 3863:: 3845:: 3521:: 2937:: 2849:: 1742:: 1731:: 1634:}} 1630:{{ 1584:. 1574:. 1564:. 1552:. 1548:. 1525:. 1515:30 1513:. 1490:. 1480:22 1478:. 1451:. 1443:. 1435:. 1423:. 1419:. 1396:. 1388:. 1378:63 1376:. 1344:. 1334:. 1324:27 1322:. 1318:. 1278:. 1268:. 1260:. 1250:67 1248:. 1244:. 1221:. 1213:. 1205:. 1195:41 1193:. 1169:. 1159:10 1157:. 1134:. 1126:. 1116:16 1114:. 1091:. 1081:. 1071:91 1069:. 1065:. 1042:. 1032:22 1030:. 1007:. 984:. 972:. 927:. 917:. 907:. 897:92 895:. 891:. 816:. 804:99 802:. 798:. 762:– 715:. 694:. 669:. 530:, 350:. 334:. 303:. 251:, 227:. 216:, 173:, 165:. 1805:) 1801:( 1791:e 1784:t 1777:v 1716:. 1697:. 1678:. 1653:. 1640:) 1626:. 1592:. 1568:: 1560:: 1533:. 1529:: 1521:: 1498:. 1486:: 1463:. 1431:: 1404:. 1392:: 1384:: 1352:. 1330:: 1286:. 1256:: 1229:. 1201:: 1177:. 1165:: 1142:. 1122:: 1099:. 1077:: 1050:. 1038:: 992:. 980:: 956:. 935:. 911:: 903:: 876:. 850:. 824:. 810:: 525:( 20:)

Index

Nuclear Polyhedrosis Virus

Virus classification
Edit this classification
Virus
Naldaviricetes
Lefavirales
Alphabaculovirus
Betabaculovirus
Deltabaculovirus
Gammabaculovirus
viruses
Arthropods
Lepidoptera
Hymenoptera
Diptera
species
sawflies
mosquitoes
mammalian
vertebrate
biopesticides
circular
double-stranded
DNA
kbp
silkworm
proteins
cell cultures
Sf21

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