305:
282:
179:
204:
311:
210:
1927:
1138:
as well as inflammatory bowel diseases to avoid thiopurine-induced leukopenia. These variants also exhibit ethnicity-specific (e.g., variant allele of rs116855232 is high is East Asians and
Hispanics but low in Caucasians and Africans). Rare functional variants in this gene have also been identified
58:
1551:
Hori M, Satou K, Harashima H, Kamiya H (May 2010). "Suppression of mutagenesis by 8-hydroxy-2'-deoxyguanosine 5'-triphosphate (7,8-dihydro-8-oxo-2'-deoxyguanosine 5'-triphosphate) by human MTH1, MTH2, and NUDT5".
1841:
Liang DC, Yang CP, Liu HC, Jaing TH, Chen SH, Hung IJ, et al. (November 2016). "NUDT15 gene polymorphism related to mercaptopurine intolerance in Taiwan
Chinese children with acute lymphoblastic leukemia".
318:
217:
1910:
1800:"NUDT15 c.415C>T increases risk of 6-mercaptopurine induced myelosuppression during maintenance therapy in children with acute lymphoblastic leukemia"
785:
766:
140:
2001:
1972:
1220:
1991:
1202:
1119:
activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early
304:
1001:
1130:
NUDT15 germline variants (e.g., a missense SNP:rs116855232, inducing R139C) have been linked to clinical usage of thiopurines (e.g.,
1008:
281:
1636:"Inherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute lymphoblastic leukemia"
1303:"Inherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute lymphoblastic leukemia"
1189:
1168:
203:
178:
1185:
55:
1164:
1135:
120:
1679:"Susceptibility to 6-MP toxicity conferred by a NUDT15 variant in Japanese children with acute lymphoblastic leukaemia"
317:
216:
1965:
310:
209:
1996:
1092:
830:
128:
1714:"NUDT15 R139C causes thiopurine-induced early severe hair loss and leukopenia in Japanese patients with IBD"
811:
1143:, suggesting the whole gene screening should be taken to determine the initial dosage using of thiopurine.
1508:"Proliferating cell nuclear antigen is protected from degradation by forming a complex with MutT Homolog2"
1088:
1958:
1749:"Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2"
192:
1798:
Chiengthong K, Ittiwut C, Muensri S, Sophonphan J, Sosothikul D, Seksan P, et al. (January 2016).
1760:
1104:
107:
1401:"Impact of NUDT15 polymorphisms on thiopurines-induced myelotoxicity and thiopurines tolerance dose"
984:
955:
929:
904:
1867:
152:
1096:
980:
959:
925:
900:
1454:
and thiopurine intolerance in children with acute lymphoblastic leukemia from diverse ancestry"
1887:
1859:
1829:
1786:
1747:
Carter M, Jemth AS, Hagenkort A, Page BD, Gustafsson R, Griese JJ, et al. (August 2015).
1735:
1700:
1665:
1622:
1579:
1539:
1483:
1430:
1381:
1332:
1283:
1252:
Moriyama T, Nishii R, Perez-Andreu V, Yang W, Klussmann FA, Zhao X, et al. (April 2016).
100:
48:
1942:
1593:"A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia"
1352:"A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia"
1851:
1819:
1811:
1776:
1768:
1725:
1690:
1677:
Tanaka Y, Kato M, Hasegawa D, Urayama KY, Nakadate H, Kondoh K, et al. (October 2015).
1655:
1647:
1612:
1604:
1569:
1561:
1529:
1519:
1473:
1465:
1420:
1412:
1371:
1363:
1322:
1314:
1273:
1265:
1100:
397:
328:
272:
227:
148:
1108:
1084:
372:
1764:
1565:
1824:
1799:
1781:
1748:
1660:
1635:
1617:
1592:
1534:
1507:
1478:
1449:
1448:
Moriyama T, Yang YL, Nishii R, Ariffin H, Liu C, Lin TN, et al. (September 2017).
1425:
1400:
1376:
1351:
1327:
1302:
1278:
1253:
1131:
700:
695:
690:
685:
680:
675:
670:
665:
660:
644:
628:
623:
618:
613:
608:
603:
598:
593:
588:
1985:
1938:
1914:
1896:
1140:
575:
1871:
1712:
Kakuta Y, Naito T, Onodera M, Kuroha M, Kimura T, Shiga H, et al. (June 2016).
132:
1112:
390:
169:
17:
1815:
1634:
Yang JJ, Landier W, Yang W, Liu C, Hageman L, Cheng C, et al. (April 2015).
1469:
1301:
Yang JJ, Landier W, Yang W, Liu C, Hageman L, Cheng C, et al. (April 2015).
156:
1225:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1207:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1591:
Yang SK, Hong M, Baek J, Choi H, Zhao W, Jung Y, et al. (September 2014).
1350:
Yang SK, Hong M, Baek J, Choi H, Zhao W, Jung Y, et al. (September 2014).
473:
1416:
1399:
Yin D, Xia X, Zhang J, Zhang S, Liao F, Zhang G, et al. (February 2017).
1124:
1120:
1116:
289:
186:
136:
1651:
1318:
1254:"NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity"
1524:
730:
533:
411:
356:
343:
255:
242:
144:
1863:
1833:
1790:
1739:
1704:
1669:
1626:
1583:
1543:
1487:
1434:
1385:
1336:
1287:
1238:
1048:
1043:
1032:
875:
856:
1855:
1730:
1713:
1901:
1891:
1772:
1064:
842:
797:
1695:
1678:
1574:
77:
1080:
1016:
752:
604:
8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
1926:
1608:
1367:
1269:
1087:
superfamily. Members of this superfamily catalyze the hydrolysis of
1506:
Yu Y, Cai JP, Tu B, Wu L, Zhao Y, Liu X, et al. (July 2009).
715:
711:
1934:
1068:
589:
8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
124:
1886:
Overview of all the structural information available in the
701:
purine deoxyribonucleoside triphosphate catabolic process
380:
1946:
1900:(Nucleotide triphosphate diphosphatase NUDT15) at the
661:
nucleobase-containing small molecule catabolic process
545:
973:
948:
918:
893:
686:
regulation of proteasomal protein catabolic process
1181:
1179:
1177:
1160:
1158:
1156:
327:
226:
1115:. The encoded enzyme is a negative regulator of
1186:GRCm38: Ensembl release 89: ENSMUSG00000033405
629:nucleoside-triphosphate diphosphatase activity
1966:
8:
1165:GRCh38: Ensembl release 89: ENSG00000136159
1973:
1959:
1911:United States National Library of Medicine
726:
571:
368:
267:
164:
66:
1823:
1780:
1729:
1694:
1659:
1616:
1573:
1533:
1523:
1477:
1424:
1375:
1326:
1277:
1909:This article incorporates text from the
1067:that in humans is encoded by the NUDT15
1152:
1139:as being related to thiopurine-induced
691:nucleoside phosphate catabolic process
26:
332:
293:
288:
231:
190:
185:
7:
1923:
1921:
1566:10.1016/j.freeradbiomed.2010.02.002
1554:Free Radical Biology & Medicine
1512:The Journal of Biological Chemistry
1127:of this gene have been identified.
696:response to reactive oxygen species
676:purine nucleotide catabolic process
111:, MTH2, NUDT15D, nudix hydrolase 15
1945:. You can help Knowledge (XXG) by
970:
945:
915:
890:
866:
847:
821:
802:
776:
757:
550:
468:
406:
385:
25:
1239:"Entrez Gene: Nudix hydrolase 15"
614:nucleotide diphosphatase activity
609:nucleoside-diphosphatase activity
1925:
316:
309:
303:
280:
215:
208:
202:
177:
2002:Human chromosome 13 gene stubs
1683:British Journal of Haematology
534:More reference expression data
1:
624:NADH pyrophosphatase activity
301:
200:
1992:Genes on human chromosome 13
1844:The Pharmacogenomics Journal
1816:10.3324/haematol.2015.134775
1718:The Pharmacogenomics Journal
1640:Journal of Clinical Oncology
1470:10.1182/blood-2017-05-782383
1307:Journal of Clinical Oncology
1136:acute lymphoblastic leukemia
1079:The NUDT15 gene encodes an
2018:
1920:
430:mucosa of transverse colon
1417:10.18632/oncotarget.14594
1221:"Mouse PubMed Reference:"
1203:"Human PubMed Reference:"
1047:
1042:
1038:
1031:
1015:
996:
977:
952:
941:
922:
897:
886:
873:
869:
854:
850:
841:
828:
824:
809:
805:
796:
783:
779:
764:
760:
751:
736:
729:
725:
709:
574:
570:
558:
553:
544:
531:
480:
471:
418:
409:
379:
371:
367:
350:
337:
300:
279:
270:
266:
249:
236:
199:
176:
167:
163:
118:
115:
105:
98:
93:
74:
69:
52:
47:
42:
38:
34:
29:
1652:10.1200/JCO.2014.59.4671
1319:10.1200/JCO.2014.59.4671
1099:, which are a result of
1009:Chr 14: 73.76 – 73.79 Mb
1002:Chr 13: 48.04 – 48.05 Mb
1525:10.1074/jbc.M109.015289
1089:nucleoside diphosphates
446:mucosa of sigmoid colon
666:dGTP catabolic process
1753:Nature Communications
450:palpebral conjunctiva
295:Chromosome 14 (mouse)
193:Chromosome 13 (human)
1083:that belongs to the
70:List of PDB id codes
43:Available structures
1856:10.1038/tpj.2015.75
1765:2015NatCo...6.7871C
1731:10.1038/tpj.2015.43
1450:"Novel variants in
454:gingival epithelium
1933:This article on a
1913:, which is in the
1773:10.1038/ncomms8871
1411:(8): 13575–13585.
1061:Nudix hydrolase 15
831:ENSMUSG00000033405
671:mitotic cell cycle
654:Biological process
638:Cellular component
594:hydrolase activity
582:Molecular function
157:NUDT15 - orthologs
18:Nudix hydrolase 15
1954:
1953:
1696:10.1111/bjh.13518
1464:(10): 1209–1212.
1103:, and can induce
1058:
1057:
1054:
1053:
1027:
1026:
992:
991:
967:
966:
937:
936:
912:
911:
882:
881:
863:
862:
837:
836:
818:
817:
792:
791:
773:
772:
721:
720:
599:metal ion binding
566:
565:
562:
561:
540:
539:
527:
526:
465:
464:
363:
362:
262:
261:
89:
88:
85:
84:
53:Ortholog search:
16:(Redirected from
2009:
1997:Nudix hydrolases
1975:
1968:
1961:
1929:
1922:
1875:
1837:
1827:
1794:
1784:
1743:
1733:
1708:
1698:
1673:
1663:
1630:
1620:
1587:
1577:
1547:
1537:
1527:
1518:(29): 19310–20.
1492:
1491:
1481:
1445:
1439:
1438:
1428:
1396:
1390:
1389:
1379:
1347:
1341:
1340:
1330:
1298:
1292:
1291:
1281:
1249:
1243:
1242:
1235:
1229:
1228:
1217:
1211:
1210:
1199:
1193:
1183:
1172:
1162:
1101:oxidative damage
1040:
1039:
1011:
1004:
987:
971:
962:
946:
942:RefSeq (protein)
932:
916:
907:
891:
867:
848:
822:
803:
777:
758:
727:
572:
551:
536:
500:ventricular zone
476:
474:Top expressed in
469:
442:secondary oocyte
426:endothelial cell
414:
412:Top expressed in
407:
386:
369:
359:
346:
335:
320:
313:
307:
296:
284:
268:
258:
245:
234:
219:
212:
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195:
181:
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159:
110:
103:
80:
67:
61:
40:
39:
27:
21:
2017:
2016:
2012:
2011:
2010:
2008:
2007:
2006:
1982:
1981:
1980:
1979:
1883:
1878:
1840:
1797:
1746:
1711:
1676:
1646:(11): 1235–42.
1633:
1609:10.1038/ng.3060
1597:Nature Genetics
1590:
1560:(9): 1197–201.
1550:
1505:
1501:
1499:Further reading
1496:
1495:
1447:
1446:
1442:
1398:
1397:
1393:
1368:10.1038/ng.3060
1356:Nature Genetics
1349:
1348:
1344:
1313:(11): 1235–42.
1300:
1299:
1295:
1270:10.1038/ng.3508
1258:Nature Genetics
1251:
1250:
1246:
1237:
1236:
1232:
1219:
1218:
1214:
1201:
1200:
1196:
1184:
1175:
1163:
1154:
1149:
1109:DNA replication
1105:base mispairing
1085:Nudix hydrolase
1077:
1049:View/Edit Mouse
1044:View/Edit Human
1007:
1000:
997:Location (UCSC)
983:
979:
958:
954:
928:
924:
903:
899:
812:ENSG00000136159
705:
649:
633:
619:protein binding
532:
523:
518:
514:
512:renal corpuscle
510:
506:
502:
498:
494:
490:
488:muscle of thigh
486:
472:
461:
456:
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448:
444:
440:
436:
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341:
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321:
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271:Gene location (
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168:Gene location (
119:
106:
99:
76:
54:
23:
22:
15:
12:
11:
5:
2015:
2013:
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2004:
1999:
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1881:External links
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1877:
1876:
1850:(6): 536–539.
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1631:
1603:(9): 1017–20.
1588:
1548:
1502:
1500:
1497:
1494:
1493:
1440:
1391:
1362:(9): 1017–20.
1342:
1293:
1244:
1230:
1212:
1194:
1173:
1151:
1150:
1148:
1145:
1132:mercaptopurine
1076:
1073:
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1051:
1046:
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1029:
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681:DNA protection
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508:tail of embryo
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373:RNA expression
365:
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51:
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44:
36:
35:
32:
31:
24:
14:
13:
10:
9:
6:
4:
3:
2:
2014:
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1990:
1989:
1987:
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1971:
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1964:
1962:
1957:
1956:
1950:
1948:
1944:
1940:
1939:chromosome 13
1936:
1931:
1928:
1924:
1919:
1918:
1916:
1915:public domain
1912:
1903:
1899:
1898:
1893:
1889:
1885:
1884:
1880:
1873:
1869:
1865:
1861:
1857:
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1849:
1845:
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1826:
1821:
1817:
1813:
1809:
1805:
1804:Haematologica
1801:
1796:
1792:
1788:
1783:
1778:
1774:
1770:
1766:
1762:
1758:
1754:
1750:
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1741:
1737:
1732:
1727:
1723:
1719:
1715:
1710:
1706:
1702:
1697:
1692:
1689:(1): 109–15.
1688:
1684:
1680:
1675:
1671:
1667:
1662:
1657:
1653:
1649:
1645:
1641:
1637:
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1610:
1606:
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1598:
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1559:
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1526:
1521:
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1513:
1509:
1504:
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1471:
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1463:
1459:
1455:
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1444:
1441:
1436:
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1427:
1422:
1418:
1414:
1410:
1406:
1402:
1395:
1392:
1387:
1383:
1378:
1373:
1369:
1365:
1361:
1357:
1353:
1346:
1343:
1338:
1334:
1329:
1324:
1320:
1316:
1312:
1308:
1304:
1297:
1294:
1289:
1285:
1280:
1275:
1271:
1267:
1264:(4): 367–73.
1263:
1259:
1255:
1248:
1245:
1240:
1234:
1231:
1226:
1222:
1216:
1213:
1208:
1204:
1198:
1195:
1191:
1187:
1182:
1180:
1178:
1174:
1170:
1166:
1161:
1159:
1157:
1153:
1146:
1144:
1142:
1141:myelotoxicity
1137:
1133:
1128:
1126:
1122:
1118:
1114:
1113:transversions
1110:
1106:
1102:
1098:
1094:
1090:
1086:
1082:
1074:
1072:
1070:
1066:
1062:
1050:
1045:
1041:
1037:
1034:
1030:
1023:
1021:
1018:
1014:
1010:
1006:
1003:
999:
995:
988:
986:
982:
976:
972:
969:
963:
961:
957:
951:
947:
944:
940:
933:
931:
927:
921:
917:
914:
908:
906:
902:
896:
892:
889:
887:RefSeq (mRNA)
885:
878:
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868:
865:
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849:
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844:
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827:
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576:Gene ontology
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334:14|14 D3
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37:
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28:
19:
1947:expanding it
1932:
1908:
1907:
1895:
1847:
1843:
1810:(1): e24-6.
1807:
1803:
1756:
1752:
1724:(3): 280–5.
1721:
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1461:
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1197:
1129:
1091:, including
1078:
1060:
1059:
985:NP_001347413
978:
956:NP_001291674
953:
930:NM_001360484
923:
905:NM_001304745
898:
874:
855:
829:
810:
784:
765:
745:
740:
484:spermatocyte
396:
389:
116:External IDs
75:
1125:pseudogenes
1123:. Multiple
520:neural tube
458:endometrium
355:73,785,682
342:73,756,317
254:48,047,221
241:48,037,726
94:Identifiers
1986:Categories
1575:2115/43020
1405:Oncotarget
1192:, May 2017
1171:, May 2017
1147:References
1121:leukopenia
1117:thiopurine
1111:, causing
1097:8-oxo-dGTP
1093:substrates
400:(ortholog)
137:HomoloGene
1937:on human
981:NP_766115
960:NP_060753
926:NM_172527
901:NM_018283
731:Orthologs
145:GeneCards
1872:13955512
1864:26503813
1834:26405151
1791:26238318
1759:: 7871.
1740:26076924
1705:26033531
1670:25624441
1627:25108385
1584:20144704
1544:19419956
1488:28659275
1435:28088792
1386:25108385
1337:25624441
1288:26878724
1188:–
1167:–
1075:Function
1033:Wikidata
710:Sources:
516:epiblast
1902:PDBe-KB
1892:UniProt
1825:4697903
1782:4532830
1761:Bibcode
1661:4375304
1618:4999337
1535:2740556
1479:5606007
1426:5355121
1377:4999337
1328:4375304
1279:5029084
1190:Ensembl
1169:Ensembl
1107:during
1065:protein
843:UniProt
798:Ensembl
737:Species
716:QuickGO
645:cytosol
375:pattern
233:13q14.2
133:2443366
101:Aliases
1897:Q9NV35
1870:
1862:
1832:
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1789:
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1738:
1703:
1668:
1658:
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1452:NUDT15
1433:
1423:
1384:
1374:
1335:
1325:
1286:
1276:
1081:enzyme
1019:search
1017:PubMed
876:Q8BG93
857:Q9NV35
786:214254
753:Entrez
546:BioGPS
504:embryo
496:embryo
492:morula
438:rectum
434:oocyte
149:NUDT15
125:615792
108:NUDT15
30:NUDT15
1941:is a
1868:S2CID
1458:Blood
1134:) in
1095:like
1063:is a
767:55270
746:Mouse
741:Human
712:Amigo
422:gonad
398:Mouse
391:Human
338:Start
273:Mouse
237:Start
170:Human
141:10109
1943:stub
1935:gene
1890:for
1860:PMID
1830:PMID
1787:PMID
1736:PMID
1701:PMID
1666:PMID
1623:PMID
1580:PMID
1540:PMID
1484:PMID
1431:PMID
1382:PMID
1333:PMID
1284:PMID
1069:gene
381:Bgee
329:Band
290:Chr.
228:Band
187:Chr.
121:OMIM
78:5BON
59:RCSB
56:PDBe
1888:PDB
1852:doi
1820:PMC
1812:doi
1808:101
1777:PMC
1769:doi
1726:doi
1691:doi
1687:171
1656:PMC
1648:doi
1613:PMC
1605:doi
1570:hdl
1562:doi
1530:PMC
1520:doi
1516:284
1474:PMC
1466:doi
1462:130
1421:PMC
1413:doi
1372:PMC
1364:doi
1323:PMC
1315:doi
1274:PMC
1266:doi
554:n/a
351:End
250:End
153:OMA
129:MGI
49:PDB
1988::
1894::
1866:.
1858:.
1848:16
1846:.
1828:.
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1806:.
1802:.
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1642:.
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1456:.
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1380:.
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1358:.
1354:.
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1321:.
1311:33
1309:.
1305:.
1282:.
1272:.
1262:48
1260:.
1256:.
1223:.
1205:.
1176:^
1155:^
1071:.
714:/
357:bp
344:bp
256:bp
243:bp
151:;
147::
143:;
139::
135:;
131::
127:;
123::
1974:e
1967:t
1960:v
1949:.
1917:.
1904:.
1874:.
1854::
1836:.
1814::
1793:.
1771::
1763::
1757:6
1742:.
1728::
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1415::
1409:8
1388:.
1366::
1339:.
1317::
1290:.
1268::
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1209:.
275:)
172:)
155::
20:)
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