319:
296:
193:
218:
570:
577:
325:
224:
42:
1671:
The NLRP3 inflammasome has garnered attention as a potential drug target for a variety of diseases underpinned by inflammation. The diarylsulfonylurea MCC-950 has been identified as a potent and selective NLRP3 inhibitor able to lock the inactive NLRP3 structure. Nodthera and
Inflazome, have entered
68:
1676:(OLT1177). This β-sulfonyl nitrile molecule compound was developed by Olactec Therapeutics, and is a selective NLRP3 inhibitor. Dapansutrile, been used in clinical trials as a remedy for heart failure, osteoarthritis and gouty arthritis.
1520:
released by damaged cells. These signals release HSP90 and SGT1 from and recruit ASC protein and caspase-1 to the inflammasome complex. Caspase-1 within the activated NLRP3 inflammasome complex in turn activates the
2435:"Keratoendotheliitis Fugax Hereditaria: A Novel Cryopyrin-Associated Periodic Syndrome Caused by a Mutation in the Nucleotide-Binding Domain, Leucine-Rich Repeat Family, Pyrin Domain-Containing 3 (NLRP3) Gene"
125:, AGTAVPRL, AII, AVP, C1orf7, CIAS1, CLR1.1, FCAS, FCAS1, FCU, MWS, NALP3, PYPAF1, NLR family, pyrin domain containing 3, NLR family pyrin domain containing 3, DFNA34, KEFH
332:
231:
1586:
3025:
1460:(LRR) motif. This protein interacts with pyrin domain (PYD) of apoptosis-associated speck-like protein containing a CARD (ASC). Proteins which contain the
975:
956:
154:
2282:
Haneklaus M, O'Neill LA, Coll RC (Feb 2013). "Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments". review.
2962:
1574:
1932:
Koonin EV, Aravind L (May 2000). "The NACHT family - a new group of predicted NTPases implicated in apoptosis and MHC transcription activation".
1570:
1753:
1735:
1590:
1481:
3214:
318:
1223:
1230:
295:
1429:
gene name abbreviates "NLR family, pyrin domain containing 3," where NLR refers to "nucleotide-binding domain, leucine-rich repeat."
2712:
1778:"Entrez Gene: NLRP3 NLR family, pyrin domain containing 3 [Homo sapiens (human)], Gene ID: 114548 (updated on 13-Nov-2015)"
1777:
3018:
1359:
2370:"Pathogenic NLRP3 mutants form constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β production"
1565:
Mutations in the NLRP3 gene result in autoactive inflammasomes and have been associated with a spectrum of dominantly inherited
1722:
1701:
2474:
Church LD, Cook GP, McDermott MF (Jan 2008). "Primer: inflammasomes and interleukin 1beta in inflammatory disorders". review.
1718:
217:
192:
65:
1477:
1697:
1628:. Amelioration of mouse models of many diseases has been shown to occur by deletion of the NLRP3 inflammasome, including
1597:
1533:
134:
2162:"Sensing low intracellular potassium by NLRP3 results in a stable open structure that promotes inflammasome activation"
3229:
3011:
1532:
The NLRP3 inflammasome appears to be activated by changes in intracellular potassium caused by potassium efflux from
331:
230:
1461:
1578:
324:
223:
1660:
1649:
1633:
1566:
1545:
1020:
142:
2329:"ASC and NLRP3 maintain innate immune homeostasis in the airway through an inflammasome-independent mechanism"
2672:
Shi F, Kouadir M, Yang Y (Aug 2015). "NALP3 inflammasome activation in protein misfolding diseases". review.
3224:
1537:
1001:
2013:"Inflammasome-associated nucleotide-binding domain, leucine-rich repeat proteins and inflammatory diseases"
1659:. For example, all the components of the NLRP3 inflammasome are downregulated or completely lost in human
1641:
1621:
1617:
1517:
1316:
3219:
1848:
Tao JH, Zhang Y, Li XP (Dec 2013). "P2X7R: a potential key regulator of acute gouty arthritis". review.
1522:
2816:"Deregulation of the NLRP3 inflammasome in hepatic parenchymal cells during liver cancer progression"
2628:
2381:
2238:
2173:
1473:
206:
121:
1457:
1377:
1206:
1167:
1163:
1159:
1155:
1135:
1096:
1092:
1088:
1084:
2857:"A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases"
2765:"The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease"
2745:
2499:
1652:
has been shown to block NLRP3 activation, and thus may be of benefit for many of these diseases.
1637:
1497:
1367:
1328:
166:
1780:. Bethesda, MD, USA: National Center for Biotechnology Information, National Library of Medicine
1202:
1181:
1171:
1131:
1110:
1100:
2519:"Potential therapeutic targets for intracerebral hemorrhage-associated inflammation: An update"
3034:
2983:
2943:
2925:
2886:
2837:
2796:
2737:
2689:
2654:
2597:
2548:
2491:
2456:
2415:
2397:
2350:
2309:
2264:
2207:
2189:
2142:
2083:
2042:
1990:
1949:
1914:
1865:
1830:
1609:
1485:
1351:
1289:) (previously known as NACHT, LRR, and PYD domains-containing protein 3 and cryopyrin), is a
569:
114:
58:
2933:
2917:
2876:
2868:
2827:
2786:
2778:
2729:
2681:
2644:
2636:
2587:
2579:
2538:
2530:
2483:
2446:
2405:
2389:
2340:
2299:
2291:
2254:
2246:
2197:
2181:
2132:
2073:
2032:
2024:
1980:
1941:
1904:
1896:
1857:
1820:
1812:
411:
342:
286:
241:
576:
162:
2769:
2720:
1645:
1324:
386:
776:
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
2632:
2617:"NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice"
2410:
2385:
2369:
2242:
2177:
1500:. NLRP3 in the absence of activating signal is kept in an inactive state complexed with
2938:
2905:
2881:
2856:
2791:
2764:
2649:
2616:
2592:
2567:
2543:
2518:
2259:
2226:
2202:
2161:
2037:
2012:
1909:
1884:
1825:
1800:
1656:
1945:
890:
885:
880:
875:
870:
865:
860:
855:
850:
845:
840:
835:
830:
825:
820:
815:
810:
805:
800:
795:
790:
785:
780:
775:
770:
765:
760:
755:
750:
745:
740:
735:
730:
725:
709:
704:
699:
694:
689:
684:
679:
674:
669:
664:
648:
643:
638:
633:
628:
623:
618:
3208:
2992:
2227:"Activation of NLRP3 inflammasome by crystalline structures via cell surface contact"
1861:
1625:
605:
2904:
Tapia-Abellán A, Angosto-Bazarra D, Martínez-Banaclocha H, et al. (June 2019).
2503:
146:
3084:
2749:
1673:
1601:
1410:
1343:
1312:
1301:
404:
183:
1540:(ROS), though the precise mechanisms of such regulation has not been determined.
170:
3177:
3043:
2708:
1758:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1740:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1613:
831:
activation of cysteine-type endopeptidase activity involved in apoptotic process
2832:
2815:
2393:
487:
2921:
2685:
2568:"Intracellular innate immunity in gouty arthritis: role of NALP3 inflammasome"
2451:
2434:
2345:
2328:
2295:
2160:
Tapia-Abellán A, Angosto-Bazarra D, Alarcón-Vila C, et al. (2021-09-17).
2062:"The PYRIN domain: a novel motif found in apoptosis and inflammation proteins"
1308:
303:
200:
150:
2929:
2534:
2401:
2193:
2028:
1327:. Mutations in the NLRP3 gene are associated with a number of organ specific
3168:
1513:
1509:
1493:
1464:, CARD, have been shown to be involved in inflammation and immune response.
1320:
920:
547:
425:
370:
357:
269:
256:
158:
3003:
2947:
2890:
2841:
2800:
2741:
2693:
2658:
2601:
2552:
2495:
2460:
2419:
2354:
2313:
2268:
2211:
2185:
2146:
2087:
2078:
2061:
2046:
1953:
1918:
1869:
1834:
1672:
phase I clinical trials with NLRP3 inhibitors. Another NLRP3 antagonist is
41:
1985:
1968:
1801:"Identification of a locus on chromosome 1q44 for familial cold urticaria"
1270:
1265:
2487:
2101:
1536:
located in the cell membrane. It appears that NLRP3 is also regulated by
1526:
1254:
1065:
1046:
2640:
2583:
2368:
Molina-López C, Hurtado-Navarro L, García CJ, et al. (2024-02-06).
2137:
2120:
1994:
1488:(NLR) subfamily of PRRs and NLRP3 together with the adaptor ASC protein
2997:
2987:
1900:
1290:
1032:
987:
2304:
2250:
91:
87:
3158:
3153:
3148:
3143:
3138:
2906:"MCC950 closes the active conformation of NLRP3 to an inactive state"
1489:
1238:
942:
17:
2872:
2782:
2733:
1433:
The NACHT, LRR and PYD domains-containing protein 3 is also called:
1816:
3193:
3133:
3128:
3123:
3118:
3113:
3108:
3103:
3098:
3093:
3074:
3069:
3064:
1582:
1554:
1550:
1505:
1501:
1453:
905:
901:
585:
3058:
3052:
1629:
1605:
1512:. NLRP3 inflammasome detects danger signals such as crystalline
1297:
138:
3007:
1581:(MWS), chronic infantile neurological cutaneous and articular (
881:
positive regulation of NF-kappaB transcription factor activity
826:
negative regulation of NF-kappaB transcription factor activity
2982:
Overview of all the structural information available in the
2327:
Fang R, Uchiyama R, Sakai S, et al. (September 2019).
2855:
Coll RC, Robertson AA, Chae JJ, et al. (March 2015).
1967:
Pueyo I, Jiménez JR, Hernández J, et al. (Sep 1978).
1799:
Hoffman HM, Wright FA, Broide DH, et al. (May 2000).
1315:, detects products of damaged cells such as extracellular
846:
positive regulation of T-helper 2 cell cytokine production
2996:(NACHT, LRR and PYD domains-containing protein 3) at the
856:
positive regulation of transcription by RNA polymerase II
2433:
Turunen JA, Wedenoja J, Repo P, et al. (Jan 2018).
1600:. In addition, the NLRP3 inflammasome has a role in the
1452:
This gene encodes a pyrin-like protein which contains a
394:
2615:
Heneka MT, Kummer MP, Stutz A, et al. (Jan 2013).
1543:
It is suggested that NLRP3 provides protection against
786:
positive regulation of T-helper 17 cell differentiation
1456:
domain, a nucleotide-binding site (NBS) domain, and a
801:
positive regulation of T-helper 2 cell differentiation
559:
1969:"Carcinoid syndrome treated by hepatic embolization"
3186:
3167:
3083:
3042:
1339:NACHT, LRR, and PYD are respectively acronyms for:
1195:
1154:
1124:
1083:
2763:Youm YH, Nguyen KY, Grant RW, et al. (2015).
1714:
1712:
1710:
1693:
1691:
1689:
746:negative regulation of acute inflammatory response
1437:cold induced autoinflammatory syndrome 1 (CIAS1),
341:
240:
2114:
2112:
2110:
1885:"Structural mechanisms of inflammasome assembly"
781:positive regulation of interleukin-13 production
1587:neonatal onset multisystem inflammatory disease
1443:PYRIN-containing APAF1-like protein 1 (PYPAF1).
766:positive regulation of interleukin-4 production
751:positive regulation of interleukin-5 production
2517:Ren H, Han R, Chen X, et al. (May 2020).
1771:
1769:
1767:
1719:GRCm38: Ensembl release 89: ENSMUSG00000032691
1655:Deregulation of NLRP3 has been connected with
1596:Defects in this gene have also been linked to
891:negative regulation of NIK/NF-kappaB signaling
3019:
2121:"Detection of immune danger signals by NALP3"
1358:2TA [class 2 transcription activator, of the
816:positive regulation of type 2 immune response
8:
836:negative regulation of inflammatory response
2814:Wei Q, Mu K, Li T, et al. (Jan 2014).
2225:Hari A, Zhang Y, Tu Z, et al. (2014).
1698:GRCh38: Ensembl release 89: ENSG00000162711
1440:caterpillar-like receptor 1.1 (CLR1.1), and
876:defense response to Gram-positive bacterium
3026:
3012:
3004:
1151:
1080:
916:
741:regulation of transcription, DNA-templated
601:
382:
281:
178:
76:
2961:Alzheimer's Drug Discovery Foundation D.
2937:
2880:
2831:
2790:
2648:
2591:
2542:
2450:
2409:
2344:
2303:
2258:
2201:
2136:
2077:
2036:
1984:
1908:
1824:
1392:epeat" and is synonymous with NLR, for
1685:
1575:familial cold autoinflammatory syndrome
841:cellular response to lipopolysaccharide
2006:
2004:
1973:AJR. American Journal of Roentgenology
1571:cryopyrin-associated periodic syndrome
1482:pathogen-associated molecular patterns
1323:. Activated NLRP3 in turn triggers an
31:
2476:Nature Clinical Practice Rheumatology
1591:keratoendotheliitis fugax hereditaria
346:
307:
302:
245:
204:
199:
7:
1850:Seminars in Arthritis and Rheumatism
1374:P1 (telomerase-associated protein 1)
1307:NLRP3 is expressed predominantly in
1283:NLR family pyrin domain containing 3
2060:Bertin J, DiStefano PS (Dec 2000).
806:regulation of inflammatory response
736:NLRP3 inflammasome complex assembly
1805:American Journal of Human Genetics
1192:
1121:
1056:
1037:
1011:
992:
966:
947:
886:cellular response to peptidoglycan
564:
482:
420:
399:
25:
2439:American Journal of Ophthalmology
1293:that in humans is encoded by the
1862:10.1016/j.semarthrit.2013.04.007
1496:activating complex known as the
575:
568:
330:
323:
317:
294:
229:
222:
216:
191:
40:
796:protein complex oligomerization
2066:Cell Death and Differentiation
1934:Trends in Biochemical Sciences
1484:(PAMPs). NLRP3 belongs to the
586:More reference expression data
548:More reference expression data
1:
2284:Current Opinion in Immunology
1946:10.1016/S0968-0004(00)01577-2
1534:mechanosensitive ion channels
811:interleukin-1 beta production
619:sequence-specific DNA binding
315:
214:
27:Human protein and coding gene
2125:Journal of Leukocyte Biology
1598:familial Mediterranean fever
1478:pattern recognition receptor
1472:NLRP3 is a component of the
1368:heterokaryon incompatibility
771:transcription, DNA-templated
731:detection of biotic stimulus
629:transcription factor binding
3215:Genes on human chromosome 1
2572:Immunology and Cell Biology
2011:Jha S, Ting JP (Dec 2009).
1614:protein-misfolding diseases
1300:located on the long arm of
3246:
2833:10.1038/labinvest.2013.126
2394:10.1038/s41467-024-44990-0
1462:caspase recruitment domain
1399:ucleotide-binding domain,
1311:and as a component of the
695:NLRP3 inflammasome complex
2922:10.1038/s41589-019-0278-6
2713:"Taming the inflammasome"
2686:10.1016/j.lfs.2015.05.011
2452:10.1016/j.ajo.2018.01.017
2346:10.1038/s41385-019-0181-1
2296:10.1016/j.coi.2012.12.004
1754:"Mouse PubMed Reference:"
1736:"Human PubMed Reference:"
1608:, hemorrhagic stroke and
1567:autoinflammatory diseases
1549:infections by activating
1269:
1264:
1260:
1253:
1237:
1224:Chr 1: 247.42 – 247.45 Mb
1218:
1199:
1178:
1147:
1128:
1107:
1076:
1063:
1059:
1044:
1040:
1031:
1018:
1014:
999:
995:
986:
973:
969:
954:
950:
941:
926:
919:
915:
899:
791:defense response to virus
756:interleukin-18 production
649:identical protein binding
604:
600:
583:
567:
558:
545:
494:
485:
432:
423:
393:
385:
381:
364:
351:
314:
293:
284:
280:
263:
250:
213:
190:
181:
177:
132:
129:
119:
112:
107:
84:
79:
62:
57:
52:
48:
39:
34:
2820:Laboratory Investigation
2566:Liu-Bryan R (Jan 2010).
2535:10.1177/0271678X20923551
2523:J Cereb Blood Flow Metab
2029:10.4049/jimmunol.0902425
1661:hepatocellular carcinoma
1546:Streptococcus pneumoniae
1231:Chr 11: 59.43 – 59.46 Mb
871:protein deubiquitination
2910:Nature Chemical Biology
2119:Martinon F (Mar 2008).
1883:Lu A, Wu H (Feb 2015).
1538:reactive oxygen species
1350:IP (neuronal apoptosis
468:upper lobe of left lung
2186:10.1126/sciadv.abf4468
2079:10.1038/sj.cdd.4400774
1573:(CAPS). This includes
1480:(PRR) that recognizes
866:innate immune response
2374:Nature Communications
2017:Journal of Immunology
1986:10.2214/ajr.131.3.511
1579:Muckle–Wells syndrome
1523:inflammatory cytokine
821:inflammatory response
761:immune system process
680:endoplasmic reticulum
639:peptidoglycan binding
506:stroma of bone marrow
309:Chromosome 11 (mouse)
2488:10.1038/ncprheum0681
1680:References and notes
1476:that functions as a
1474:innate immune system
685:inflammasome complex
675:extracellular region
530:olfactory epithelium
207:Chromosome 1 (human)
80:List of PDB id codes
53:Available structures
2707:Levy M, Thaiss CA,
2641:10.1038/nature11729
2633:2013Natur.493..674H
2584:10.1038/icb.2009.93
2386:2024NatCo..15.1096M
2243:2014NatSR...4E7281H
2178:2021SciA....7.4468T
2138:10.1189/jlb.0607362
1642:Alzheimer's disease
1458:leucine-rich repeat
1329:autoimmune diseases
851:signal transduction
522:submandibular gland
3230:NOD-like receptors
3171:inhibitory protein
2333:Mucosal Immunology
2231:Scientific Reports
1901:10.1111/febs.13133
1638:multiple sclerosis
1516:and extracellular
1498:NLRP3 inflammasome
1421:omain," after the
1021:ENSMUSG00000032691
719:Biological process
658:Cellular component
624:nucleotide binding
612:Molecular function
3202:
3201:
3035:NOD-like receptor
2251:10.1038/srep07281
1650:β-hydroxybutyrate
1610:neuroinflammation
1486:NOD-like receptor
1352:inhibitor protein
1280:
1279:
1276:
1275:
1249:
1248:
1214:
1213:
1189:
1188:
1143:
1142:
1118:
1117:
1072:
1071:
1053:
1052:
1027:
1026:
1008:
1007:
982:
981:
963:
962:
911:
910:
861:apoptotic process
596:
595:
592:
591:
554:
553:
541:
540:
479:
478:
448:bone marrow cells
377:
376:
276:
275:
171:NLRP3 - orthologs
103:
102:
99:
98:
63:Ortholog search:
16:(Redirected from
3237:
3187:Family member X1
3028:
3021:
3014:
3005:
2970:
2969:
2967:
2958:
2952:
2951:
2941:
2901:
2895:
2894:
2884:
2852:
2846:
2845:
2835:
2811:
2805:
2804:
2794:
2760:
2754:
2753:
2717:
2704:
2698:
2697:
2669:
2663:
2662:
2652:
2612:
2606:
2605:
2595:
2563:
2557:
2556:
2546:
2529:(9): 1752–1768.
2514:
2508:
2507:
2471:
2465:
2464:
2454:
2430:
2424:
2423:
2413:
2365:
2359:
2358:
2348:
2339:(5): 1092–1103.
2324:
2318:
2317:
2307:
2279:
2273:
2272:
2262:
2222:
2216:
2215:
2205:
2172:(38): eabf4468.
2166:Science Advances
2157:
2151:
2150:
2140:
2116:
2105:
2104:
2098:
2092:
2091:
2081:
2057:
2051:
2050:
2040:
2008:
1999:
1998:
1988:
1964:
1958:
1957:
1929:
1923:
1922:
1912:
1889:The FEBS Journal
1880:
1874:
1873:
1845:
1839:
1838:
1828:
1796:
1790:
1789:
1787:
1785:
1773:
1762:
1761:
1750:
1744:
1743:
1732:
1726:
1716:
1705:
1695:
1319:and crystalline
1262:
1261:
1233:
1226:
1209:
1193:
1184:
1152:
1148:RefSeq (protein)
1138:
1122:
1113:
1081:
1057:
1038:
1012:
993:
967:
948:
917:
726:defense response
602:
588:
579:
572:
565:
550:
490:
488:Top expressed in
483:
428:
426:Top expressed in
421:
400:
383:
373:
360:
349:
334:
327:
321:
310:
298:
282:
272:
259:
248:
233:
226:
220:
209:
195:
179:
173:
124:
117:
94:
77:
71:
50:
49:
44:
32:
21:
3245:
3244:
3240:
3239:
3238:
3236:
3235:
3234:
3205:
3204:
3203:
3198:
3182:
3163:
3079:
3038:
3032:
2979:
2974:
2973:
2965:
2960:
2959:
2955:
2903:
2902:
2898:
2873:10.1038/nm.3806
2861:Nature Medicine
2854:
2853:
2849:
2813:
2812:
2808:
2783:10.1038/nm.3804
2770:Nature Medicine
2762:
2761:
2757:
2734:10.1038/nm.3808
2721:Nature Medicine
2715:
2706:
2705:
2701:
2671:
2670:
2666:
2627:(7434): 674–8.
2614:
2613:
2609:
2565:
2564:
2560:
2516:
2515:
2511:
2473:
2472:
2468:
2432:
2431:
2427:
2367:
2366:
2362:
2326:
2325:
2321:
2281:
2280:
2276:
2224:
2223:
2219:
2159:
2158:
2154:
2118:
2117:
2108:
2100:
2099:
2095:
2059:
2058:
2054:
2010:
2009:
2002:
1966:
1965:
1961:
1931:
1930:
1926:
1882:
1881:
1877:
1847:
1846:
1842:
1798:
1797:
1793:
1783:
1781:
1775:
1774:
1765:
1752:
1751:
1747:
1734:
1733:
1729:
1717:
1708:
1696:
1687:
1682:
1669:
1648:. The compound
1646:atherosclerosis
1634:type 2 diabetes
1563:
1470:
1450:
1337:
1325:immune response
1271:View/Edit Mouse
1266:View/Edit Human
1229:
1222:
1219:Location (UCSC)
1205:
1201:
1180:
1174:
1170:
1166:
1162:
1158:
1134:
1130:
1109:
1103:
1099:
1095:
1091:
1087:
1002:ENSG00000162711
895:
714:
705:Golgi apparatus
653:
634:protein binding
584:
574:
573:
546:
537:
532:
528:
524:
520:
516:
512:
508:
504:
500:
486:
475:
470:
466:
462:
458:
454:
450:
446:
442:
438:
424:
368:
355:
348:11|11 B1.3
347:
337:
336:
335:
328:
308:
285:Gene location (
267:
254:
246:
236:
235:
234:
227:
205:
182:Gene location (
133:
120:
113:
86:
64:
28:
23:
22:
15:
12:
11:
5:
3243:
3241:
3233:
3232:
3227:
3225:Human proteins
3222:
3217:
3207:
3206:
3200:
3199:
3197:
3196:
3190:
3188:
3184:
3183:
3181:
3180:
3174:
3172:
3165:
3164:
3162:
3161:
3156:
3151:
3146:
3141:
3136:
3131:
3126:
3121:
3116:
3111:
3106:
3101:
3096:
3090:
3088:
3081:
3080:
3078:
3077:
3072:
3067:
3062:
3056:
3049:
3047:
3040:
3039:
3033:
3031:
3030:
3023:
3016:
3008:
3002:
3001:
2978:
2977:External links
2975:
2972:
2971:
2963:"Dapansutrile"
2953:
2916:(6): 560–564.
2896:
2847:
2806:
2777:(3): 263–269.
2755:
2728:(3): 213–215.
2699:
2664:
2607:
2558:
2509:
2466:
2425:
2360:
2319:
2274:
2217:
2152:
2106:
2093:
2072:(12): 1273–4.
2052:
2023:(12): 7623–9.
2000:
1959:
1924:
1875:
1840:
1817:10.1086/302874
1791:
1776:Anon. (2015).
1763:
1745:
1727:
1706:
1684:
1683:
1681:
1678:
1668:
1665:
1657:carcinogenesis
1626:prion diseases
1562:
1559:
1469:
1466:
1449:
1446:
1445:
1444:
1441:
1438:
1431:
1430:
1425:proteins. The
1408:
1375:
1336:
1333:
1278:
1277:
1274:
1273:
1268:
1258:
1257:
1251:
1250:
1247:
1246:
1244:
1242:
1235:
1234:
1227:
1220:
1216:
1215:
1212:
1211:
1197:
1196:
1190:
1187:
1186:
1176:
1175:
1149:
1145:
1144:
1141:
1140:
1126:
1125:
1119:
1116:
1115:
1105:
1104:
1078:
1074:
1073:
1070:
1069:
1061:
1060:
1054:
1051:
1050:
1042:
1041:
1035:
1029:
1028:
1025:
1024:
1016:
1015:
1009:
1006:
1005:
997:
996:
990:
984:
983:
980:
979:
971:
970:
964:
961:
960:
952:
951:
945:
939:
938:
933:
928:
924:
923:
913:
912:
909:
908:
897:
896:
894:
893:
888:
883:
878:
873:
868:
863:
858:
853:
848:
843:
838:
833:
828:
823:
818:
813:
808:
803:
798:
793:
788:
783:
778:
773:
768:
763:
758:
753:
748:
743:
738:
733:
728:
722:
720:
716:
715:
713:
712:
707:
702:
700:Golgi membrane
697:
692:
687:
682:
677:
672:
667:
661:
659:
655:
654:
652:
651:
646:
641:
636:
631:
626:
621:
615:
613:
609:
608:
598:
597:
594:
593:
590:
589:
581:
580:
562:
556:
555:
552:
551:
543:
542:
539:
538:
536:
535:
531:
527:
523:
519:
515:
511:
507:
503:
499:
495:
492:
491:
480:
477:
476:
474:
473:
469:
465:
461:
457:
453:
449:
445:
441:
437:
433:
430:
429:
417:
416:
408:
397:
391:
390:
387:RNA expression
379:
378:
375:
374:
366:
362:
361:
353:
350:
345:
339:
338:
329:
322:
316:
312:
311:
306:
300:
299:
291:
290:
278:
277:
274:
273:
265:
261:
260:
252:
249:
244:
238:
237:
228:
221:
215:
211:
210:
203:
197:
196:
188:
187:
175:
174:
131:
127:
126:
118:
110:
109:
105:
104:
101:
100:
97:
96:
82:
81:
73:
72:
61:
55:
54:
46:
45:
37:
36:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
3242:
3231:
3228:
3226:
3223:
3221:
3218:
3216:
3213:
3212:
3210:
3195:
3192:
3191:
3189:
3185:
3179:
3176:
3175:
3173:
3170:
3166:
3160:
3157:
3155:
3152:
3150:
3147:
3145:
3142:
3140:
3137:
3135:
3132:
3130:
3127:
3125:
3122:
3120:
3117:
3115:
3112:
3110:
3107:
3105:
3102:
3100:
3097:
3095:
3092:
3091:
3089:
3086:
3082:
3076:
3073:
3071:
3068:
3066:
3063:
3060:
3057:
3054:
3051:
3050:
3048:
3045:
3041:
3036:
3029:
3024:
3022:
3017:
3015:
3010:
3009:
3006:
2999:
2995:
2994:
2989:
2985:
2981:
2980:
2976:
2964:
2957:
2954:
2949:
2945:
2940:
2935:
2931:
2927:
2923:
2919:
2915:
2911:
2907:
2900:
2897:
2892:
2888:
2883:
2878:
2874:
2870:
2867:(3): 248–55.
2866:
2862:
2858:
2851:
2848:
2843:
2839:
2834:
2829:
2825:
2821:
2817:
2810:
2807:
2802:
2798:
2793:
2788:
2784:
2780:
2776:
2772:
2771:
2766:
2759:
2756:
2751:
2747:
2743:
2739:
2735:
2731:
2727:
2723:
2722:
2714:
2710:
2703:
2700:
2695:
2691:
2687:
2683:
2679:
2675:
2674:Life Sciences
2668:
2665:
2660:
2656:
2651:
2646:
2642:
2638:
2634:
2630:
2626:
2622:
2618:
2611:
2608:
2603:
2599:
2594:
2589:
2585:
2581:
2577:
2573:
2569:
2562:
2559:
2554:
2550:
2545:
2540:
2536:
2532:
2528:
2524:
2520:
2513:
2510:
2505:
2501:
2497:
2493:
2489:
2485:
2481:
2477:
2470:
2467:
2462:
2458:
2453:
2448:
2444:
2440:
2436:
2429:
2426:
2421:
2417:
2412:
2407:
2403:
2399:
2395:
2391:
2387:
2383:
2379:
2375:
2371:
2364:
2361:
2356:
2352:
2347:
2342:
2338:
2334:
2330:
2323:
2320:
2315:
2311:
2306:
2301:
2297:
2293:
2289:
2285:
2278:
2275:
2270:
2266:
2261:
2256:
2252:
2248:
2244:
2240:
2236:
2232:
2228:
2221:
2218:
2213:
2209:
2204:
2199:
2195:
2191:
2187:
2183:
2179:
2175:
2171:
2167:
2163:
2156:
2153:
2148:
2144:
2139:
2134:
2131:(3): 507–11.
2130:
2126:
2122:
2115:
2113:
2111:
2107:
2103:
2097:
2094:
2089:
2085:
2080:
2075:
2071:
2067:
2063:
2056:
2053:
2048:
2044:
2039:
2034:
2030:
2026:
2022:
2018:
2014:
2007:
2005:
2001:
1996:
1992:
1987:
1982:
1978:
1974:
1970:
1963:
1960:
1955:
1951:
1947:
1943:
1939:
1935:
1928:
1925:
1920:
1916:
1911:
1906:
1902:
1898:
1895:(3): 435–44.
1894:
1890:
1886:
1879:
1876:
1871:
1867:
1863:
1859:
1856:(3): 376–80.
1855:
1851:
1844:
1841:
1836:
1832:
1827:
1822:
1818:
1814:
1811:(5): 1693–8.
1810:
1806:
1802:
1795:
1792:
1779:
1772:
1770:
1768:
1764:
1759:
1755:
1749:
1746:
1741:
1737:
1731:
1728:
1724:
1720:
1715:
1713:
1711:
1707:
1703:
1699:
1694:
1692:
1690:
1686:
1679:
1677:
1675:
1666:
1664:
1662:
1658:
1653:
1651:
1647:
1643:
1639:
1635:
1631:
1627:
1623:
1619:
1615:
1612:occurring in
1611:
1607:
1603:
1599:
1594:
1592:
1589:(NOMID), and
1588:
1584:
1580:
1576:
1572:
1568:
1560:
1558:
1556:
1552:
1548:
1547:
1541:
1539:
1535:
1530:
1528:
1524:
1519:
1515:
1511:
1507:
1503:
1499:
1495:
1491:
1487:
1483:
1479:
1475:
1467:
1465:
1463:
1459:
1455:
1447:
1442:
1439:
1436:
1435:
1434:
1428:
1424:
1420:
1416:
1412:
1409:
1406:
1402:
1398:
1395:
1391:
1387:
1383:
1379:
1376:
1373:
1369:
1365:
1361:
1357:
1353:
1349:
1345:
1342:
1341:
1340:
1334:
1332:
1330:
1326:
1322:
1318:
1314:
1310:
1305:
1303:
1299:
1296:
1292:
1288:
1284:
1272:
1267:
1263:
1259:
1256:
1252:
1245:
1243:
1240:
1236:
1232:
1228:
1225:
1221:
1217:
1210:
1208:
1204:
1198:
1194:
1191:
1185:
1183:
1177:
1173:
1169:
1165:
1161:
1157:
1153:
1150:
1146:
1139:
1137:
1133:
1127:
1123:
1120:
1114:
1112:
1106:
1102:
1098:
1094:
1090:
1086:
1082:
1079:
1077:RefSeq (mRNA)
1075:
1068:
1067:
1062:
1058:
1055:
1049:
1048:
1043:
1039:
1036:
1034:
1030:
1023:
1022:
1017:
1013:
1010:
1004:
1003:
998:
994:
991:
989:
985:
978:
977:
972:
968:
965:
959:
958:
953:
949:
946:
944:
940:
937:
934:
932:
929:
925:
922:
918:
914:
907:
903:
898:
892:
889:
887:
884:
882:
879:
877:
874:
872:
869:
867:
864:
862:
859:
857:
854:
852:
849:
847:
844:
842:
839:
837:
834:
832:
829:
827:
824:
822:
819:
817:
814:
812:
809:
807:
804:
802:
799:
797:
794:
792:
789:
787:
784:
782:
779:
777:
774:
772:
769:
767:
764:
762:
759:
757:
754:
752:
749:
747:
744:
742:
739:
737:
734:
732:
729:
727:
724:
723:
721:
718:
717:
711:
708:
706:
703:
701:
698:
696:
693:
691:
688:
686:
683:
681:
678:
676:
673:
671:
668:
666:
663:
662:
660:
657:
656:
650:
647:
645:
642:
640:
637:
635:
632:
630:
627:
625:
622:
620:
617:
616:
614:
611:
610:
607:
606:Gene ontology
603:
599:
587:
582:
578:
571:
566:
563:
561:
557:
549:
544:
533:
529:
525:
521:
517:
513:
509:
505:
501:
497:
496:
493:
489:
484:
481:
471:
467:
463:
459:
455:
451:
447:
443:
439:
435:
434:
431:
427:
422:
419:
418:
415:
413:
409:
407:
406:
402:
401:
398:
396:
392:
388:
384:
380:
372:
367:
363:
359:
354:
344:
340:
333:
326:
320:
313:
305:
301:
297:
292:
288:
283:
279:
271:
266:
262:
258:
253:
243:
239:
232:
225:
219:
212:
208:
202:
198:
194:
189:
185:
180:
176:
172:
168:
164:
160:
156:
152:
148:
144:
140:
136:
128:
123:
116:
111:
106:
95:
93:
89:
83:
78:
75:
74:
70:
67:
60:
56:
51:
47:
43:
38:
33:
30:
19:
3220:LRR proteins
3085:Pyrin domain
2991:
2956:
2913:
2909:
2899:
2864:
2860:
2850:
2826:(1): 52–62.
2823:
2819:
2809:
2774:
2768:
2758:
2725:
2719:
2702:
2677:
2673:
2667:
2624:
2620:
2610:
2575:
2571:
2561:
2526:
2522:
2512:
2482:(1): 34–42.
2479:
2475:
2469:
2442:
2438:
2428:
2377:
2373:
2363:
2336:
2332:
2322:
2290:(1): 40–45.
2287:
2283:
2277:
2234:
2230:
2220:
2169:
2165:
2155:
2128:
2124:
2096:
2069:
2065:
2055:
2020:
2016:
1979:(3): 511–3.
1976:
1972:
1962:
1940:(5): 223–4.
1937:
1933:
1927:
1892:
1888:
1878:
1853:
1849:
1843:
1808:
1804:
1794:
1782:. Retrieved
1757:
1748:
1739:
1730:
1674:Dapansutrile
1670:
1654:
1602:pathogenesis
1595:
1585:) syndrome,
1564:
1544:
1542:
1531:
1471:
1451:
1432:
1426:
1422:
1418:
1414:
1404:
1403:eucine-rich
1400:
1396:
1393:
1389:
1385:
1381:
1371:
1363:
1355:
1347:
1338:
1335:Nomenclature
1313:inflammasome
1306:
1302:chromosome 1
1294:
1286:
1282:
1281:
1207:NP_001346567
1200:
1179:
1168:NP_001230062
1164:NP_001120934
1160:NP_001120933
1156:NP_001073289
1136:NM_001359638
1129:
1108:
1097:NM_001243133
1093:NM_001127462
1089:NM_001127461
1085:NM_001079821
1064:
1045:
1019:
1000:
974:
955:
935:
930:
410:
403:
268:247,449,108
255:247,416,156
130:External IDs
85:
29:
3044:CARD domain
2578:(1): 20–3.
2380:(1): 1096.
1784:13 November
1622:Parkinson's
1618:Alzheimer's
1309:macrophages
644:ATP binding
498:granulocyte
452:gallbladder
440:granulocyte
369:59,457,782
356:59,432,394
108:Identifiers
3209:Categories
3087:containing
3046:containing
2570:. review.
2305:2262/72554
2123:. review.
2064:. review.
1887:. review.
1725:, May 2017
1704:, May 2017
1667:Inhibition
1616:, such as
460:right lung
414:(ortholog)
151:HomoloGene
3169:Apoptosis
2930:1552-4450
2445:: 41–50.
2402:2041-1723
2194:2375-2548
1561:Pathology
1514:uric acid
1510:cytoplasm
1494:caspase-1
1448:Structure
1321:uric acid
1203:NP_665826
1182:NP_899632
1172:NP_004886
1132:NM_145827
1111:NM_183395
1101:NM_004895
921:Orthologs
665:cytoplasm
159:GeneCards
2948:31086329
2891:25686105
2842:24166187
2801:25686106
2742:25742454
2711:(2015).
2709:Elinav E
2694:26037399
2680:: 9–14.
2659:23254930
2602:19935768
2553:32423330
2504:19986204
2496:18172447
2461:29366613
2420:38321014
2411:10847128
2355:31278375
2314:23305783
2269:25445147
2237:: 7281.
2212:34524838
2147:17982111
2088:11270363
2047:20007570
1954:10782090
1919:25354325
1870:23786870
1835:10741953
1721:–
1700:–
1577:(FCAS),
1492:forms a
1468:Function
1255:Wikidata
900:Sources:
710:membrane
534:meninges
526:gastrula
514:calvaria
464:appendix
456:testicle
436:monocyte
2998:PDBe-KB
2988:UniProt
2939:7116292
2882:4392179
2792:4352123
2750:6659540
2650:3812809
2629:Bibcode
2593:4337950
2544:7446569
2382:Bibcode
2260:4250918
2239:Bibcode
2203:8443177
2174:Bibcode
2038:3666034
1910:6400279
1826:1378006
1723:Ensembl
1702:Ensembl
1569:called
1508:in the
1384:eucine-
1291:protein
1033:UniProt
988:Ensembl
927:Species
906:QuickGO
690:nucleus
670:cytosol
389:pattern
147:2653833
115:Aliases
3159:NLRP14
3154:NLRP13
3149:NLRP12
3144:NLRP11
3139:NLRP10
3061:/NLRC2
3055:/NLRC1
3037:family
2993:Q96P20
2946:
2936:
2928:
2889:
2879:
2840:
2799:
2789:
2748:
2740:
2692:
2657:
2647:
2621:Nature
2600:
2590:
2551:
2541:
2502:
2494:
2459:
2418:
2408:
2400:
2353:
2312:
2267:
2257:
2210:
2200:
2192:
2145:
2102:Q96P20
2086:
2045:
2035:
1993:
1952:
1917:
1907:
1868:
1833:
1823:
1644:, and
1624:, and
1490:PYCARD
1407:epeat"
1370:) and
1366:ET-E (
1241:search
1239:PubMed
1066:Q8R4B8
1047:Q96P20
976:216799
957:114548
943:Entrez
560:BioGPS
518:spleen
510:morula
472:spleen
139:606416
3194:NLRX1
3134:NLRP9
3129:NLRP8
3124:NLRP7
3119:NLRP6
3114:NLRP5
3109:NLRP4
3104:NLRP3
3099:NLRP2
3094:NLRP1
3075:NLRC5
3070:NLRC4
3065:NLRC3
2966:(PDF)
2746:S2CID
2716:(PDF)
2500:S2CID
1995:99001
1583:CINCA
1555:SPDEF
1551:STAT6
1527:IL-1β
1502:HSP90
1454:pyrin
1427:NLRP3
1423:pyrin
1417:YRIN
1344:NACHT
1295:NLRP3
1287:NLRP3
936:Mouse
931:Human
902:Amigo
502:blood
444:blood
412:Mouse
405:Human
352:Start
287:Mouse
251:Start
184:Human
163:NLRP3
122:NLRP3
35:NLRP3
18:NALP3
3178:NAIP
3059:NOD2
3053:NOD1
2986:for
2944:PMID
2926:ISSN
2887:PMID
2838:PMID
2797:PMID
2738:PMID
2690:PMID
2655:PMID
2598:PMID
2549:PMID
2492:PMID
2457:PMID
2416:PMID
2398:ISSN
2351:PMID
2310:PMID
2265:PMID
2208:PMID
2190:ISSN
2143:PMID
2084:PMID
2043:PMID
1991:PMID
1950:PMID
1915:PMID
1866:PMID
1831:PMID
1786:2015
1630:gout
1606:gout
1553:and
1506:SGT1
1504:and
1388:ich
1298:gene
395:Bgee
343:Band
304:Chr.
247:1q44
242:Band
201:Chr.
155:3600
135:OMIM
92:2NAQ
88:3QF2
69:RCSB
66:PDBe
2984:PDB
2934:PMC
2918:doi
2877:PMC
2869:doi
2828:doi
2787:PMC
2779:doi
2730:doi
2682:doi
2678:135
2645:PMC
2637:doi
2625:493
2588:PMC
2580:doi
2539:PMC
2531:doi
2484:doi
2447:doi
2443:184
2406:PMC
2390:doi
2341:doi
2300:hdl
2292:doi
2255:PMC
2247:doi
2198:PMC
2182:doi
2133:doi
2074:doi
2033:PMC
2025:doi
2021:183
1981:doi
1977:131
1942:doi
1905:PMC
1897:doi
1893:282
1858:doi
1821:PMC
1813:doi
1604:of
1518:ATP
1413:– "
1411:PYD
1394:or
1380:– "
1378:LRR
1360:MHC
1354:),
1317:ATP
365:End
264:End
167:OMA
143:MGI
59:PDB
3211::
2990::
2942:.
2932:.
2924:.
2914:15
2912:.
2908:.
2885:.
2875:.
2865:21
2863:.
2859:.
2836:.
2824:94
2822:.
2818:.
2795:.
2785:.
2775:21
2773:.
2767:.
2744:.
2736:.
2726:21
2724:.
2718:.
2688:.
2676:.
2653:.
2643:.
2635:.
2623:.
2619:.
2596:.
2586:.
2576:88
2574:.
2547:.
2537:.
2527:40
2525:.
2521:.
2498:.
2490:.
2478:.
2455:.
2441:.
2437:.
2414:.
2404:.
2396:.
2388:.
2378:15
2376:.
2372:.
2349:.
2337:12
2335:.
2331:.
2308:.
2298:.
2288:25
2286:.
2263:.
2253:.
2245:.
2233:.
2229:.
2206:.
2196:.
2188:.
2180:.
2168:.
2164:.
2141:.
2129:83
2127:.
2109:^
2082:.
2068:.
2041:.
2031:.
2019:.
2015:.
2003:^
1989:.
1975:.
1971:.
1948:.
1938:25
1936:.
1913:.
1903:.
1891:.
1864:.
1854:43
1852:.
1829:.
1819:.
1809:66
1807:.
1803:.
1766:^
1756:.
1738:.
1709:^
1688:^
1663:.
1640:,
1636:,
1632:,
1620:,
1593:.
1557:.
1529:.
1525:,
1362:,
1348:NA
1346:–
1331:.
1304:.
904:/
371:bp
358:bp
270:bp
257:bp
165:;
161::
157:;
153::
149:;
145::
141:;
137::
90:,
3027:e
3020:t
3013:v
3000:.
2968:.
2950:.
2920::
2893:.
2871::
2844:.
2830::
2803:.
2781::
2752:.
2732::
2696:.
2684::
2661:.
2639::
2631::
2604:.
2582::
2555:.
2533::
2506:.
2486::
2480:4
2463:.
2449::
2422:.
2392::
2384::
2357:.
2343::
2316:.
2302::
2294::
2271:.
2249::
2241::
2235:4
2214:.
2184::
2176::
2170:7
2149:.
2135::
2090:.
2076::
2070:7
2049:.
2027::
1997:.
1983::
1956:.
1944::
1921:.
1899::
1872:.
1860::
1837:.
1815::
1788:.
1760:.
1742:.
1419:d
1415:P
1405:r
1401:l
1397:n
1390:r
1386:r
1382:l
1372:T
1364:H
1356:C
1285:(
289:)
186:)
169::
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
