330:
307:
204:
229:
581:
2584:
336:
235:
29:
2385:
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P,
55:
1243:(HNSCC). When 160 human DNA repair genes were evaluated for aberrant methylation in HNSCC tumors, 62% of tumors were hypermethylated in the NEIL1 promoter region, causing NEIL1 messenger RNA and NEIL1 protein to be repressed. When 8 DNA repair genes were evaluated in
1247:(NSCLC) tumors, 42% were hypermethylated in the NEIL1 promoter region. This was the most frequent DNA repair deficiency found among the 8 DNA repair genes tested. NEIL1 was also one of six DNA repair genes found to be hypermethylated in their promoter regions in
1215:. NEIL1 is also capable of removing lesions from single-stranded DNA as well as from bubble and forked DNA structures. Because the expression of NEIL1 is cell-cycle dependent, and because it acts on forked DNA structures and interacts with
2431:
Ocampo-Hafalla MT, Altamirano A, Basu AK, Chan MK, Ocampo JE, Cummings A, Boorstein RJ, Cunningham RP, Teebor GW (Apr 2006). "Repair of thymine glycol by hNth1 and hNeil1 is modulated by base pairing and cis-trans epimerization".
1664:
Farkas SA, Vymetalkova V, Vodickova L, Vodicka P, Nilsson TK (Apr 2014). "DNA methylation changes in genes frequently mutated in sporadic colorectal cancer and in the DNA repair and Wnt/Ξ²-catenin signaling pathway genes".
2386:
Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network".
2320:
Zhang QM, Yonekura S, Takao M, Yasui A, Sugiyama H, Yonei S (Jan 2005). "DNA glycosylase activities for thymine residues oxidized in the methyl group are functions of the hNEIL1 and hNTH1 enzymes in human cells".
1296:
mutations in DNA repair genes cause only 2β5% of cases. However, methylation of the promoter region of DNA repair genes (including NEIL1), are frequently associated with colon cancers and may be an important
1262:, are often evaluated for epigenetic repression in many types of cancer, epigenetic deficiency of NEIL1 is usually not evaluated, but might be of importance in such cancers as well.
2291:
Mokkapati SK, Wiederhold L, Hazra TK, Mitra S (Sep 2004). "Stimulation of DNA glycosylase activity of OGG1 by NEIL1: functional collaboration between two human DNA glycosylases".
1563:
Chaisaingmongkol J, Popanda O, Warta R, Dyckhoff G, Herpel E, Geiselhart L, Claus R, Lasitschka F, Campos B, Oakes CC, Bermejo JL, Herold-Mende C, Plass C, Schmezer P (Dec 2012).
2036:
Bandaru V, Sunkara S, Wallace SS, Bond JP (Jul 2002). "A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to
Escherichia coli endonuclease VIII".
1792:
Cuozzo C, Porcellini A, Angrisano T, Morano A, Lee B, Di Pardo A, Messina S, Iuliano R, Fusco A, Santillo MR, Muller MT, Chiariotti L, Gottesman ME, Avvedimento EV (Jul 2007).
343:
242:
1265:
DNA damage appears to be the primary underlying cause of cancer. If DNA repair is deficient, DNA damage tends to accumulate. Such excess DNA damage may increase
1897:"Endonuclease VIII-like 1 (NEIL1) promotes short-term spatial memory retention and protects from ischemic stroke-induced brain dysfunction and death in mice"
2221:
Wiederhold L, Leppard JB, Kedar P, Karimi-Busheri F, Rasouli-Nia A, Weinfeld M, Tomkinson AE, Izumi T, Prasad R, Wilson SH, Mitra S, Hazra TK (Jul 2004).
1995:"Human DNA glycosylases of the bacterial Fpg/MutM superfamily: an alternative pathway for the repair of 8-oxoguanine and other oxidation products in DNA"
859:
840:
165:
1325:-induced brain dysfunction and death in mice. NEIL1 deficiency causes brain damage and a functionally defective outcome in a mouse model of stroke.
2583:
2137:"Overproduction, crystallization and preliminary crystallographic analysis of a novel human DNA-repair enzyme that recognizes oxidative DNA damage"
1255:
1220:
2612:
2563:
1428:
1410:
1240:
52:
1565:"Epigenetic screen of human DNA repair genes identifies aberrant promoter methylation of NEIL1 in head and neck squamous cell carcinoma"
329:
1216:
1091:
1098:
2170:"The crystal structure of human endonuclease VIII-like 1 (NEIL1) reveals a zincless finger motif required for glycosylase activity"
1743:"Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island"
306:
1500:
1397:
1376:
228:
203:
1393:
1244:
1372:
2102:"Differential specificity of human and Escherichia coli endonuclease III and VIII homologues for oxidative base lesions"
1448:"Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA"
145:
342:
241:
1212:
335:
234:
2556:
2463:"Evaluation of NTHL1, NEIL1, NEIL2, MPG, TDG, UNG and SMUG1 genes in familial colorectal cancer predisposition"
904:
153:
2617:
1188:
1176:
885:
1349:
1702:"DNA damage responses: mechanisms and roles in human disease: 2007 G.H.A. Clowes Memorial Award Lecture"
1281:
alterations due to errors during DNA repair. Such mutations and epigenetic alterations may give rise to
217:
2549:
2395:
2181:
1908:
1617:
1172:
132:
1606:"A critical re-assessment of DNA repair gene promoter methylation in non-small cell lung carcinoma"
1074:
1049:
1045:
1037:
1011:
986:
982:
974:
2256:
Shinmura K, Tao H, Goto M, Igarashi H, Taniguchi T, Maekawa M, Takezaki T, Sugimura H (Dec 2004).
2419:
1236:
177:
2352:"Induction of the human oxidized base-specific DNA glycosylase NEIL1 by reactive oxygen species"
1960:"A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue"
1070:
1041:
1007:
978:
2529:
2494:
2449:
2411:
2373:
2338:
2308:
2279:
2244:
2209:
2156:
2123:
2088:
2053:
2024:
1981:
1936:
1874:
1825:
1774:
1723:
1682:
1643:
1586:
1545:
1479:
1248:
1211:
lesions, guanidinohydantoin, and spiroiminodihydantoin that are further oxidation products of
580:
125:
45:
2067:"Repair of oxidized bases in DNA bubble structures by human DNA glycosylases NEIL1 and NEIL2"
2519:
2484:
2474:
2441:
2403:
2363:
2330:
2300:
2269:
2234:
2199:
2189:
2148:
2113:
2078:
2045:
2014:
2006:
1971:
1926:
1916:
1864:
1856:
1815:
1805:
1764:
1754:
1713:
1674:
1633:
1625:
1576:
1535:
1527:
1469:
1459:
1446:
Hazra TK, Izumi T, Boldogh I, Imhoff B, Kow YW, Jaruga P, Dizdaroglu M, Mitra S (Mar 2002).
422:
353:
297:
252:
173:
1270:
1171:
homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in
1168:
397:
2399:
2185:
1958:
Takao M, Kanno S, Kobayashi K, Zhang QM, Yonei S, van der Horst GT, Yasui A (Nov 2002).
1912:
1621:
2489:
2462:
2258:"Inactivating mutations of the human base excision repair gene NEIL1 in gastric cancer"
1931:
1896:
1869:
1844:
1820:
1793:
1769:
1742:
1638:
1605:
1540:
1515:
1310:
1204:
28:
2204:
2169:
2049:
2019:
1994:
1474:
1447:
774:
769:
764:
759:
754:
749:
744:
739:
723:
718:
713:
708:
703:
698:
682:
677:
672:
667:
662:
657:
647:
642:
637:
632:
627:
622:
2606:
2461:
Broderick P, Bagratuni T, Vijayakrishnan J, Lubbe S, Chandler I, Houlston RS (2006).
609:
1531:
1313:
retention. Mice lacking NEIL1 have impaired memory retention in a water maze test.
157:
2423:
1895:
Canugovi C, Yoon JS, Feldman NH, Croteau DL, Mattson MP, Bohr VA (September 2012).
415:
194:
1718:
1701:
1223:, it has been proposed that NEIL1 functions in replication associated DNA repair.
2445:
2334:
2239:
2222:
2100:
Katafuchi A, Nakano T, Masaoka A, Terato H, Iwai S, Hanaoka F, Ide H (Apr 2004).
1860:
1810:
1759:
1195:
via Ξ²,Ξ΄ elimination, leaving 3β² and 5β² phosphate ends. NEIL1 recognizes oxidized
181:
1433:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1415:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1278:
2508:"Damage specificity of human DNA glycosylases for oxidative pyrimidine lesions"
2174:
Proceedings of the
National Academy of Sciences of the United States of America
1452:
Proceedings of the
National Academy of Sciences of the United States of America
498:
2152:
1274:
1266:
1232:
1196:
314:
211:
161:
2524:
2507:
2479:
2274:
2257:
2194:
1921:
1604:
Do H, Wong NC, Murone C, John T, Solomon B, Mitchell PL, Dobrovic A (2014).
1516:"Variant base excision repair proteins: contributors to genomic instability"
1298:
1293:
1208:
1179:(ROS) and introducing a DNA strand break via the associated lyase reaction.
804:
558:
436:
381:
368:
280:
267:
169:
2533:
2498:
2453:
2415:
2377:
2368:
2351:
2342:
2312:
2283:
2248:
2213:
2160:
2127:
2118:
2101:
2092:
2083:
2066:
2057:
2028:
1985:
1976:
1959:
1940:
1878:
1829:
1778:
1727:
1686:
1647:
1590:
1549:
1483:
1464:
1138:
1133:
2010:
1581:
1564:
1286:
1122:
949:
930:
2407:
1993:
Morland I, Rolseth V, Luna L, Rognes T, BjΓΈrΓ₯s M, Seeberg E (Nov 2002).
652:
1200:
1192:
916:
871:
2304:
1629:
102:
98:
94:
90:
86:
82:
78:
74:
2506:
Katafuchi A, Matsubara M, Terato H, Iwai S, Hanaoka F, Ide H (2007).
2223:"AP endonuclease-independent DNA base excision repair in human cells"
1678:
1322:
1282:
1154:
1106:
826:
2136:
1344:
1339:
1334:
1203:
residues oxidized at the methyl group, and both stereoisomers of
789:
785:
683:
class I DNA-(apurinic or apyrimidinic site) endonuclease activity
1259:
1161:
589:
149:
2545:
2541:
2592:: Crystal structure of human endonuclease VIII-like 1 (NEIL1)
2350:
Das A, Hazra TK, Boldogh I, Mitra S, Bhakat KK (Oct 2005).
1794:"DNA damage, homology-directed repair, and DNA methylation"
1501:"Entrez Gene: NEIL1 nei endonuclease VIII-like 1 (E. coli)"
1843:
Jasperson KW, Tuohy TM, Neklason DW, Burt RW (Jun 2010).
678:
DNA-(apurinic or apyrimidinic site) endonuclease activity
1207:. The best substrates for human NEIL1 appear to be the
405:
2135:
Bandaru V, Cooper W, Wallace SS, DoubliΓ© S (Jun 2004).
2168:
DoubliΓ© S, Bandaru V, Bond JP, Wallace SS (Jul 2004).
570:
633:
hydrolase activity, hydrolyzing N-glycosyl compounds
1063:
1030:
1000:
967:
1389:
1387:
1385:
1368:
1366:
1364:
352:
251:
1890:
1888:
1187:NEIL1 recognizes (targets) and removes certain
136:, FPG1, NEI1, hFPG1, nei like DNA glycosylase 1
1659:
1657:
1394:GRCm38: Ensembl release 89: ENSMUSG00000032298
2557:
8:
1514:Nemec AA, Wallace SS, Sweasy JB (Oct 2010).
638:hydrolase activity, acting on glycosyl bonds
1741:O'Hagan HM, Mohammad HP, Baylin SB (2008).
1373:GRCh38: Ensembl release 89: ENSG00000140398
2564:
2550:
2542:
800:
605:
393:
292:
189:
63:
2523:
2488:
2478:
2367:
2273:
2238:
2203:
2193:
2117:
2082:
2018:
1975:
1930:
1920:
1868:
1819:
1809:
1768:
1758:
1717:
1637:
1580:
1539:
1473:
1463:
1495:
1493:
760:negative regulation of nuclease activity
750:cellular response to DNA damage stimulus
2579:
1360:
1845:"Hereditary and familial colon cancer"
1277:. Excess DNA damage may also increase
1254:While other DNA repair genes, such as
18:
2065:Dou H, Mitra S, Hazra TK (Dec 2003).
1321:NEIL1 also protects against ischemic
1241:head and neck squamous cell carcinoma
357:
318:
313:
256:
215:
210:
7:
1191:-damaged bases and then incises the
2356:The Journal of Biological Chemistry
2106:The Journal of Biological Chemistry
2071:The Journal of Biological Chemistry
1964:The Journal of Biological Chemistry
1060:
1027:
997:
964:
940:
921:
895:
876:
850:
831:
575:
493:
431:
410:
14:
1157:that in humans is encoded by the
2582:
2141:Acta Crystallographica Section D
579:
341:
334:
328:
305:
240:
233:
227:
202:
27:
1532:10.1016/j.semcancer.2010.10.010
2512:Nucleic Acids Symposium Series
590:More reference expression data
559:More reference expression data
451:right hemisphere of cerebellum
1:
2050:10.1016/S1568-7864(02)00036-8
1719:10.1158/1541-7786.MCR-08-0020
1175:by cleaving bases damaged by
709:microtubule organizing center
326:
225:
16:Protein-coding gene in humans
2613:Genes on human chromosome 15
2446:10.1016/j.dnarep.2005.12.004
2335:10.1016/j.dnarep.2004.08.002
2240:10.1016/j.molcel.2004.06.003
1901:Proc. Natl. Acad. Sci. U.S.A
1861:10.1053/j.gastro.2010.01.054
1811:10.1371/journal.pgen.0030110
1760:10.1371/journal.pgen.1000155
1167:NEIL1 belongs to a class of
745:response to oxidative stress
479:right lobe of thyroid gland
2634:
1520:Seminars in Cancer Biology
1309:NEIL1 promotes short-term
1301:factor for these cancers.
1245:non-small cell lung cancer
740:nucleotide-excision repair
673:DNA N-glycosylase activity
648:protein C-terminus binding
2577:
2153:10.1107/S0907444904007929
1429:"Mouse PubMed Reference:"
1411:"Human PubMed Reference:"
1137:
1132:
1128:
1121:
1105:
1086:
1067:
1034:
1023:
1004:
971:
960:
947:
943:
928:
924:
915:
902:
898:
883:
879:
870:
857:
853:
838:
834:
825:
810:
803:
799:
783:
608:
604:
587:
578:
569:
556:
505:
496:
443:
434:
404:
396:
392:
375:
362:
325:
304:
295:
291:
274:
261:
224:
201:
192:
188:
143:
140:
130:
123:
118:
71:
66:
49:
44:
39:
35:
26:
21:
1199:, formamidopyrimidines,
1151:Endonuclease VIII-like 1
1092:Chr 15: 75.35 β 75.36 Mb
2480:10.1186/1471-2407-6-243
2195:10.1073/pnas.0402051101
1922:10.1073/pnas.1204156109
1177:reactive oxygen species
1099:Chr 9: 57.05 β 57.06 Mb
2369:10.1074/jbc.M505526200
2119:10.1074/jbc.M400393200
2084:10.1074/jbc.M308658200
1999:Nucleic Acids Research
1977:10.1074/jbc.M206884200
1465:10.1073/pnas.062053799
1235:genes most frequently
509:mesenteric lymph nodes
2525:10.1093/nass/48.1.175
2275:10.1093/carcin/bgh267
1275:translesion synthesis
463:minor salivary glands
218:Chromosome 15 (human)
1582:10.1038/onc.2011.660
1231:NEIL1 is one of the
1227:Deficiency in cancer
1173:base excision repair
775:base-excision repair
663:nucleic acid binding
529:brown adipose tissue
455:right adrenal cortex
320:Chromosome 9 (mouse)
67:List of PDB id codes
40:Available structures
2408:10.1038/nature04209
2400:2005Natur.437.1173R
2186:2004PNAS..10110284D
1913:2012PNAS..10914948C
1622:2014NatSR...4E4186D
1287:malignant neoplasms
1273:due to error-prone
643:damaged DNA binding
517:submandibular gland
475:right lobe of liver
471:canal of the cervix
467:left adrenal cortex
2011:10.1093/nar/gkf618
1700:Kastan MB (2008).
1610:Scientific Reports
905:ENSMUSG00000032298
733:Biological process
692:Cellular component
668:hydrolase activity
653:catalytic activity
616:Molecular function
483:anterior pituitary
459:right frontal lobe
447:right uterine tube
2600:
2599:
2305:10.1021/bi049097i
2299:(36): 11596β604.
1630:10.1038/srep04186
1317:Stroke prevention
1292:In colon cancer,
1249:colorectal cancer
1148:
1147:
1144:
1143:
1117:
1116:
1082:
1081:
1057:
1056:
1019:
1018:
994:
993:
956:
955:
937:
936:
911:
910:
892:
891:
866:
865:
847:
846:
795:
794:
600:
599:
596:
595:
565:
564:
552:
551:
490:
489:
388:
387:
287:
286:
182:NEIL1 - orthologs
114:
113:
110:
109:
50:Ortholog search:
2625:
2586:
2566:
2559:
2552:
2543:
2537:
2527:
2502:
2492:
2482:
2457:
2427:
2394:(7062): 1173β8.
2381:
2371:
2362:(42): 35272β80.
2346:
2316:
2287:
2277:
2252:
2242:
2217:
2207:
2197:
2164:
2147:(Pt 6): 1142β4.
2131:
2121:
2112:(14): 14464β71.
2096:
2086:
2077:(50): 49679β84.
2061:
2032:
2022:
1989:
1979:
1970:(44): 42205β13.
1945:
1944:
1934:
1924:
1907:(37): 14948β53.
1892:
1883:
1882:
1872:
1849:Gastroenterology
1840:
1834:
1833:
1823:
1813:
1789:
1783:
1782:
1772:
1762:
1738:
1732:
1731:
1721:
1697:
1691:
1690:
1679:10.2217/epi.14.7
1661:
1652:
1651:
1641:
1601:
1595:
1594:
1584:
1560:
1554:
1553:
1543:
1511:
1505:
1504:
1497:
1488:
1487:
1477:
1467:
1443:
1437:
1436:
1425:
1419:
1418:
1407:
1401:
1391:
1380:
1370:
1305:Memory retention
1169:DNA glycosylases
1130:
1129:
1101:
1094:
1077:
1061:
1052:
1028:
1024:RefSeq (protein)
1014:
998:
989:
965:
941:
922:
896:
877:
851:
832:
801:
755:depyrimidination
628:zinc ion binding
606:
592:
583:
576:
561:
501:
499:Top expressed in
494:
439:
437:Top expressed in
432:
411:
394:
384:
371:
360:
345:
338:
332:
321:
309:
293:
283:
270:
259:
244:
237:
231:
220:
206:
190:
184:
135:
128:
105:
64:
58:
37:
36:
31:
19:
2633:
2632:
2628:
2627:
2626:
2624:
2623:
2622:
2603:
2602:
2601:
2596:
2593:
2587:
2573:
2570:
2540:
2505:
2460:
2430:
2384:
2349:
2319:
2290:
2255:
2220:
2180:(28): 10284β9.
2167:
2134:
2099:
2064:
2035:
2005:(22): 4926β36.
1992:
1957:
1953:
1951:Further reading
1948:
1894:
1893:
1886:
1842:
1841:
1837:
1791:
1790:
1786:
1753:(8): e1000155.
1740:
1739:
1735:
1706:Mol. Cancer Res
1699:
1698:
1694:
1663:
1662:
1655:
1603:
1602:
1598:
1575:(49): 5108β16.
1562:
1561:
1557:
1513:
1512:
1508:
1499:
1498:
1491:
1445:
1444:
1440:
1427:
1426:
1422:
1409:
1408:
1404:
1392:
1383:
1371:
1362:
1358:
1331:
1319:
1307:
1271:DNA replication
1237:hypermethylated
1229:
1185:
1139:View/Edit Mouse
1134:View/Edit Human
1097:
1090:
1087:Location (UCSC)
1073:
1069:
1048:
1044:
1040:
1036:
1010:
1006:
985:
981:
977:
973:
886:ENSG00000140398
779:
728:
687:
588:
557:
548:
545:muscle of thigh
543:
541:proximal tubule
539:
535:
531:
527:
523:
519:
515:
511:
497:
486:
481:
477:
473:
469:
465:
461:
457:
453:
449:
435:
379:
366:
358:
348:
347:
346:
339:
319:
296:Gene location (
278:
265:
257:
247:
246:
245:
238:
216:
193:Gene location (
144:
131:
124:
73:
51:
17:
12:
11:
5:
2631:
2629:
2621:
2620:
2618:Human proteins
2615:
2605:
2604:
2598:
2597:
2595:
2594:
2588:
2581:
2578:
2575:
2574:
2571:
2569:
2568:
2561:
2554:
2546:
2539:
2538:
2503:
2458:
2428:
2382:
2347:
2317:
2288:
2268:(12): 2311β7.
2262:Carcinogenesis
2253:
2227:Molecular Cell
2218:
2165:
2132:
2097:
2062:
2033:
1990:
1954:
1952:
1949:
1947:
1946:
1884:
1855:(6): 2044β58.
1835:
1784:
1733:
1692:
1653:
1596:
1555:
1506:
1489:
1438:
1420:
1402:
1381:
1359:
1357:
1354:
1353:
1352:
1347:
1342:
1337:
1330:
1327:
1318:
1315:
1311:spatial memory
1306:
1303:
1269:errors during
1228:
1225:
1205:thymine glycol
1184:
1181:
1146:
1145:
1142:
1141:
1136:
1126:
1125:
1119:
1118:
1115:
1114:
1112:
1110:
1103:
1102:
1095:
1088:
1084:
1083:
1080:
1079:
1065:
1064:
1058:
1055:
1054:
1032:
1031:
1025:
1021:
1020:
1017:
1016:
1002:
1001:
995:
992:
991:
969:
968:
962:
958:
957:
954:
953:
945:
944:
938:
935:
934:
926:
925:
919:
913:
912:
909:
908:
900:
899:
893:
890:
889:
881:
880:
874:
868:
867:
864:
863:
855:
854:
848:
845:
844:
836:
835:
829:
823:
822:
817:
812:
808:
807:
797:
796:
793:
792:
781:
780:
778:
777:
772:
767:
762:
757:
752:
747:
742:
736:
734:
730:
729:
727:
726:
721:
716:
711:
706:
701:
695:
693:
689:
688:
686:
685:
680:
675:
670:
665:
660:
658:lyase activity
655:
650:
645:
640:
635:
630:
625:
619:
617:
613:
612:
602:
601:
598:
597:
594:
593:
585:
584:
573:
567:
566:
563:
562:
554:
553:
550:
549:
547:
546:
542:
538:
534:
530:
526:
522:
518:
514:
510:
506:
503:
502:
491:
488:
487:
485:
484:
480:
476:
472:
468:
464:
460:
456:
452:
448:
444:
441:
440:
428:
427:
419:
408:
402:
401:
398:RNA expression
390:
389:
386:
385:
377:
373:
372:
364:
361:
356:
350:
349:
340:
333:
327:
323:
322:
317:
311:
310:
302:
301:
289:
288:
285:
284:
276:
272:
271:
263:
260:
255:
249:
248:
239:
232:
226:
222:
221:
214:
208:
207:
199:
198:
186:
185:
142:
138:
137:
129:
121:
120:
116:
115:
112:
111:
108:
107:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
2630:
2619:
2616:
2614:
2611:
2610:
2608:
2591:
2585:
2580:
2576:
2567:
2562:
2560:
2555:
2553:
2548:
2547:
2544:
2535:
2531:
2526:
2521:
2517:
2513:
2509:
2504:
2500:
2496:
2491:
2486:
2481:
2476:
2472:
2468:
2464:
2459:
2455:
2451:
2447:
2443:
2440:(4): 444β54.
2439:
2435:
2429:
2425:
2421:
2417:
2413:
2409:
2405:
2401:
2397:
2393:
2389:
2383:
2379:
2375:
2370:
2365:
2361:
2357:
2353:
2348:
2344:
2340:
2336:
2332:
2328:
2324:
2318:
2314:
2310:
2306:
2302:
2298:
2294:
2289:
2285:
2281:
2276:
2271:
2267:
2263:
2259:
2254:
2250:
2246:
2241:
2236:
2233:(2): 209β20.
2232:
2228:
2224:
2219:
2215:
2211:
2206:
2201:
2196:
2191:
2187:
2183:
2179:
2175:
2171:
2166:
2162:
2158:
2154:
2150:
2146:
2142:
2138:
2133:
2129:
2125:
2120:
2115:
2111:
2107:
2103:
2098:
2094:
2090:
2085:
2080:
2076:
2072:
2068:
2063:
2059:
2055:
2051:
2047:
2044:(7): 517β29.
2043:
2039:
2034:
2030:
2026:
2021:
2016:
2012:
2008:
2004:
2000:
1996:
1991:
1987:
1983:
1978:
1973:
1969:
1965:
1961:
1956:
1955:
1950:
1942:
1938:
1933:
1928:
1923:
1918:
1914:
1910:
1906:
1902:
1898:
1891:
1889:
1885:
1880:
1876:
1871:
1866:
1862:
1858:
1854:
1850:
1846:
1839:
1836:
1831:
1827:
1822:
1817:
1812:
1807:
1803:
1799:
1798:PLOS Genetics
1795:
1788:
1785:
1780:
1776:
1771:
1766:
1761:
1756:
1752:
1748:
1747:PLOS Genetics
1744:
1737:
1734:
1729:
1725:
1720:
1715:
1712:(4): 517β24.
1711:
1707:
1703:
1696:
1693:
1688:
1684:
1680:
1676:
1673:(2): 179β91.
1672:
1668:
1660:
1658:
1654:
1649:
1645:
1640:
1635:
1631:
1627:
1623:
1619:
1615:
1611:
1607:
1600:
1597:
1592:
1588:
1583:
1578:
1574:
1570:
1566:
1559:
1556:
1551:
1547:
1542:
1537:
1533:
1529:
1525:
1521:
1517:
1510:
1507:
1502:
1496:
1494:
1490:
1485:
1481:
1476:
1471:
1466:
1461:
1458:(6): 3523β8.
1457:
1453:
1449:
1442:
1439:
1434:
1430:
1424:
1421:
1416:
1412:
1406:
1403:
1399:
1395:
1390:
1388:
1386:
1382:
1378:
1374:
1369:
1367:
1365:
1361:
1355:
1351:
1348:
1346:
1343:
1341:
1338:
1336:
1333:
1332:
1328:
1326:
1324:
1316:
1314:
1312:
1304:
1302:
1300:
1295:
1290:
1288:
1284:
1280:
1276:
1272:
1268:
1263:
1261:
1257:
1252:
1250:
1246:
1242:
1238:
1234:
1226:
1224:
1222:
1218:
1214:
1210:
1206:
1202:
1198:
1194:
1190:
1182:
1180:
1178:
1174:
1170:
1165:
1163:
1160:
1156:
1152:
1140:
1135:
1131:
1127:
1124:
1120:
1113:
1111:
1108:
1104:
1100:
1096:
1093:
1089:
1085:
1078:
1076:
1072:
1066:
1062:
1059:
1053:
1051:
1047:
1043:
1039:
1033:
1029:
1026:
1022:
1015:
1013:
1009:
1003:
999:
996:
990:
988:
984:
980:
976:
970:
966:
963:
961:RefSeq (mRNA)
959:
952:
951:
946:
942:
939:
933:
932:
927:
923:
920:
918:
914:
907:
906:
901:
897:
894:
888:
887:
882:
878:
875:
873:
869:
862:
861:
856:
852:
849:
843:
842:
837:
833:
830:
828:
824:
821:
818:
816:
813:
809:
806:
802:
798:
791:
787:
782:
776:
773:
771:
768:
766:
763:
761:
758:
756:
753:
751:
748:
746:
743:
741:
738:
737:
735:
732:
731:
725:
722:
720:
717:
715:
712:
710:
707:
705:
702:
700:
697:
696:
694:
691:
690:
684:
681:
679:
676:
674:
671:
669:
666:
664:
661:
659:
656:
654:
651:
649:
646:
644:
641:
639:
636:
634:
631:
629:
626:
624:
621:
620:
618:
615:
614:
611:
610:Gene ontology
607:
603:
591:
586:
582:
577:
574:
572:
568:
560:
555:
544:
540:
536:
532:
528:
524:
521:otolith organ
520:
516:
512:
508:
507:
504:
500:
495:
492:
482:
478:
474:
470:
466:
462:
458:
454:
450:
446:
445:
442:
438:
433:
430:
429:
426:
424:
420:
418:
417:
413:
412:
409:
407:
403:
399:
395:
391:
383:
378:
374:
370:
365:
355:
351:
344:
337:
331:
324:
316:
312:
308:
303:
299:
294:
290:
282:
277:
273:
269:
264:
254:
250:
243:
236:
230:
223:
219:
213:
209:
205:
200:
196:
191:
187:
183:
179:
175:
171:
167:
163:
159:
155:
151:
147:
139:
134:
127:
122:
117:
106:
104:
100:
96:
92:
88:
84:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
2589:
2518:(1): 175β6.
2515:
2511:
2470:
2466:
2437:
2433:
2391:
2387:
2359:
2355:
2326:
2322:
2296:
2293:Biochemistry
2292:
2265:
2261:
2230:
2226:
2177:
2173:
2144:
2140:
2109:
2105:
2074:
2070:
2041:
2037:
2002:
1998:
1967:
1963:
1904:
1900:
1852:
1848:
1838:
1801:
1797:
1787:
1750:
1746:
1736:
1709:
1705:
1695:
1670:
1666:
1613:
1609:
1599:
1572:
1568:
1558:
1526:(5): 320β8.
1523:
1519:
1509:
1455:
1451:
1441:
1432:
1423:
1414:
1405:
1320:
1308:
1291:
1264:
1253:
1230:
1186:
1166:
1158:
1150:
1149:
1075:NP_001344338
1068:
1050:NP_001339449
1046:NP_001339448
1038:NP_001243481
1035:
1012:NM_001357409
1005:
987:NM_001352520
983:NM_001352519
975:NM_001256552
972:
948:
929:
903:
884:
858:
839:
819:
814:
714:cytoskeleton
537:right kidney
421:
414:
141:External IDs
72:
2572:PDB gallery
2329:(1): 71β9.
1804:(7): e110.
1667:Epigenomics
1197:pyrimidines
1193:abasic site
724:nucleoplasm
623:DNA binding
380:57,055,589
367:57,050,084
279:75,357,115
266:75,346,955
119:Identifiers
2607:Categories
2467:BMC Cancer
2434:DNA Repair
2323:DNA Repair
2038:DNA Repair
1400:, May 2017
1379:, May 2017
1356:References
1279:epigenetic
1267:mutational
1233:DNA repair
770:DNA repair
765:metabolism
704:chromosome
425:(ortholog)
359:9|9 B
162:HomoloGene
1294:germ line
1209:hydantoin
1071:NP_082623
1042:NP_078884
1008:NM_028347
979:NM_024608
805:Orthologs
699:cytoplasm
170:GeneCards
2534:17150535
2499:17029639
2454:16446124
2416:16189514
2378:16118226
2343:15533839
2313:15350146
2284:15319300
2249:15260972
2214:15232006
2161:15159582
2128:14734554
2093:14522990
2058:12509226
2029:12433996
1986:12200441
1941:22927410
1879:20420945
1830:17616978
1779:18704159
1728:18403632
1687:24811787
1648:24569633
1616:: 4186.
1591:22286769
1569:Oncogene
1550:20955798
1484:11904416
1396:–
1375:–
1329:See also
1123:Wikidata
784:Sources:
2490:1624846
2473:: 243.
2424:4427026
2396:Bibcode
2182:Bibcode
1932:3443144
1909:Bibcode
1870:3057468
1821:1913100
1770:2491723
1639:3935198
1618:Bibcode
1541:3254599
1398:Ensembl
1377:Ensembl
1201:thymine
1183:Targets
917:UniProt
872:Ensembl
811:Species
790:QuickGO
719:nucleus
525:utricle
400:pattern
258:15q24.2
158:1920024
126:Aliases
2532:
2497:
2487:
2452:
2422:
2414:
2388:Nature
2376:
2341:
2311:
2282:
2247:
2212:
2205:478564
2202:
2159:
2126:
2091:
2056:
2027:
2020:137166
2017:
1984:
1939:
1929:
1877:
1867:
1828:
1818:
1777:
1767:
1726:
1685:
1646:
1636:
1589:
1548:
1538:
1482:
1475:122556
1472:
1323:stroke
1299:causal
1283:cancer
1213:8-oxoG
1155:enzyme
1153:is an
1109:search
1107:PubMed
950:Q8K4Q6
931:Q96FI4
827:Entrez
571:BioGPS
513:thymus
150:608844
2420:S2CID
1345:NTHL1
1340:NEIL3
1335:NEIL2
1285:(see
1221:FEN-1
1159:NEIL1
860:72774
841:79661
820:Mouse
815:Human
786:Amigo
423:Mouse
416:Human
363:Start
298:Mouse
262:Start
195:Human
174:NEIL1
166:11616
133:NEIL1
22:NEIL1
2590:1tdh
2530:PMID
2495:PMID
2450:PMID
2412:PMID
2374:PMID
2339:PMID
2309:PMID
2280:PMID
2245:PMID
2210:PMID
2157:PMID
2124:PMID
2089:PMID
2054:PMID
2025:PMID
1982:PMID
1937:PMID
1875:PMID
1826:PMID
1775:PMID
1724:PMID
1683:PMID
1644:PMID
1587:PMID
1546:PMID
1480:PMID
1350:OGG1
1260:MLH1
1258:and
1256:MGMT
1219:and
1217:PCNA
1162:gene
533:hand
406:Bgee
354:Band
315:Chr.
253:Band
212:Chr.
146:OMIM
103:5ITT
99:5ITR
95:5ITX
91:5ITU
87:5ITQ
83:5ITY
79:4NRV
75:1TDH
56:RCSB
53:PDBe
2520:doi
2485:PMC
2475:doi
2442:doi
2404:doi
2392:437
2364:doi
2360:280
2331:doi
2301:doi
2270:doi
2235:doi
2200:PMC
2190:doi
2178:101
2149:doi
2114:doi
2110:279
2079:doi
2075:278
2046:doi
2015:PMC
2007:doi
1972:doi
1968:277
1927:PMC
1917:doi
1905:109
1865:PMC
1857:doi
1853:138
1816:PMC
1806:doi
1765:PMC
1755:doi
1714:doi
1675:doi
1634:PMC
1626:doi
1577:doi
1536:PMC
1528:doi
1470:PMC
1460:doi
1289:).
1239:in
1189:ROS
376:End
275:End
178:OMA
154:MGI
46:PDB
2609::
2528:.
2516:48
2514:.
2510:.
2493:.
2483:.
2469:.
2465:.
2448:.
2436:.
2418:.
2410:.
2402:.
2390:.
2372:.
2358:.
2354:.
2337:.
2325:.
2307:.
2297:43
2295:.
2278:.
2266:25
2264:.
2260:.
2243:.
2231:15
2229:.
2225:.
2208:.
2198:.
2188:.
2176:.
2172:.
2155:.
2145:60
2143:.
2139:.
2122:.
2108:.
2104:.
2087:.
2073:.
2069:.
2052:.
2040:.
2023:.
2013:.
2003:30
2001:.
1997:.
1980:.
1966:.
1962:.
1935:.
1925:.
1915:.
1903:.
1899:.
1887:^
1873:.
1863:.
1851:.
1847:.
1824:.
1814:.
1800:.
1796:.
1773:.
1763:.
1749:.
1745:.
1722:.
1708:.
1704:.
1681:.
1669:.
1656:^
1642:.
1632:.
1624:.
1612:.
1608:.
1585:.
1573:31
1571:.
1567:.
1544:.
1534:.
1524:20
1522:.
1518:.
1492:^
1478:.
1468:.
1456:99
1454:.
1450:.
1431:.
1413:.
1384:^
1363:^
1251:.
1164:.
788:/
382:bp
369:bp
281:bp
268:bp
176:;
172::
168:;
164::
160:;
156::
152:;
148::
101:,
97:,
93:,
89:,
85:,
81:,
77:,
2565:e
2558:t
2551:v
2536:.
2522::
2501:.
2477::
2471:6
2456:.
2444::
2438:5
2426:.
2406::
2398::
2380:.
2366::
2345:.
2333::
2327:4
2315:.
2303::
2286:.
2272::
2251:.
2237::
2216:.
2192::
2184::
2163:.
2151::
2130:.
2116::
2095:.
2081::
2060:.
2048::
2042:1
2031:.
2009::
1988:.
1974::
1943:.
1919::
1911::
1881:.
1859::
1832:.
1808::
1802:3
1781:.
1757::
1751:4
1730:.
1716::
1710:6
1689:.
1677::
1671:6
1650:.
1628::
1620::
1614:4
1593:.
1579::
1552:.
1530::
1503:.
1486:.
1462::
1435:.
1417:.
300:)
197:)
180::
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