315:
292:
189:
214:
580:
573:
566:
2626:
42:
321:
220:
1249:) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells. In
1255:, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the
1482:
Simpson MA, Irving MD, Asilmaz E, Gray MJ, Dafou D, Elmslie FV, Mansour S, Holder SE, Brain CE, Burton BK, Kim KH, Pauli RM, Aftimos S, Stewart H, Kim CA, Holder-Espinasse M, Robertson SP, Drake WM, Trembath RC (2011-03-06). "Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and
1446:
Samejima H, Torii C, Kosaki R, Kurosawa K, Yoshihashi H, Muroya K, Okamoto N, Watanabe Y, Kosho T, Kubota M, Matsuda O, Goto M, Izumi K, Takahashi T, Kosaki K (2007). "Screening for
Alagille syndrome mutations in the JAG1 and NOTCH2 genes using denaturing high-performance liquid chromatography".
1584:
Isidor B, Lindenbaum P, Pichon O, Bézieau S, Dina C, Jacquemont S, Martin-Coignard D, Thauvin-Robinet C, Le Merrer M, Mandel JL, David A, Faivre L, Cormier-Daire V, Redon R, Le
Caignec C (2011). "Truncating mutations in the last exon of NOTCH2 cause a rare skeletal disorder with osteoporosis".
68:
2065:
Katsanis N, Fitzgibbon J, Fisher EM (1996). "Paralogy mapping: identification of a region in the human MHC triplicated onto human chromosomes 1 and 9 allows the prediction and isolation of novel PBX and NOTCH loci".
1410:
Larsson C, Lardelli M, White I, Lendahl U (May 1995). "The human NOTCH1, 2, and 3 genes are located at chromosome positions 9q34, 1p13-p11, and 19p13.2-p13.1 in regions of neoplasia-associated translocation".
1540:
Simpson MA, Irving MD, Asilmaz E, Gray MJ, Dafou D, Elmslie FV, Mansour S, Holder SE, et al. (2011). "Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and progressive bone loss".
2382:
Wu L, Aster JC, Blacklow SC, Lake R, Artavanis-Tsakonas S, Griffin JD (2001). "MAML1, a human homologue of
Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors".
2028:
Stifani S, Blaumueller CM, Redhead NJ, Hill RE, Artavanis-Tsakonas S (1993). "Human homologs of a
Drosophila Enhancer of split gene product define a novel family of nuclear proteins".
1259:, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development.
328:
227:
2666:
1628:
Majewski J, Schwartzentruber JA, Caqueret A, Patry L, Marcadier J, Fryns JP, Boycott KM, Ste-Marie LG, McKiernan FE, Marik I, Van Esch H, Michaud JL, Samuels ME (2011).
2419:
Sriuranpong V, Borges MW, Ravi RK, Arnold DR, Nelkin BD, Baylin SB, Ball DW (2001). "Notch signaling induces cell cycle arrest in small cell lung cancer cells".
2625:
933:
914:
150:
2766:
1991:
Schwarzmeier JD, Hubmann R, Düchler M, Jäger U, Shehata M (2005). "Regulation of CD23 expression by Notch2 in B-cell chronic lymphocytic leukemia".
2224:
Berezovska O, Xia MQ, Hyman BT (1998). "Notch is expressed in adult brain, is coexpressed with presenilin-1, and is altered in
Alzheimer disease".
2659:
2605:
1392:
1374:
2787:
2442:"Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation"
1682:"Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation"
2341:"Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2"
1728:"Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2"
1141:
314:
1148:
291:
2652:
2261:
Gray GE, Mann RS, Mitsiadis E, Henrique D, Carcangiu ML, Banks A, Leiman J, Ward D, Ish-Horowitz D, Artavanis-Tsakonas S (1999).
1526:
1361:
1340:
1245:
family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (
2557:
1357:
1911:
Artavanis-Tsakonas S, Rand MD, Lake RJ (1999). "Notch signaling: cell fate control and signal integration in development".
213:
188:
65:
1336:
1271:
1242:
130:
1287:
327:
226:
1826:"Phosphorylation by glycogen synthase kinase-3 beta down-regulates Notch activity, a link for Notch and Wnt pathways"
320:
219:
1275:
1226:
2598:
978:
138:
2306:"Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods"
1867:"Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods"
2552:
2687:
2679:
1246:
1238:
959:
1865:
Shimizu K, Chiba S, Kumano K, Hosoya N, Takahashi T, Kanda Y, Hamada Y, Yazaki Y, Hirai H (November 1999).
1726:
Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H (September 2000).
2719:
2591:
1920:
202:
117:
2675:
1099:
1048:
2304:
Shimizu K, Chiba S, Kumano K, Hosoya N, Takahashi T, Kanda Y, Hamada Y, Yazaki Y, Hirai H (2000).
2407:
2249:
2169:
2053:
2016:
1944:
1806:
1659:
1610:
1566:
1508:
162:
2339:
Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H (2000).
1124:
1103:
1073:
1052:
579:
572:
565:
2563:
2533:
2498:
2463:
2428:
2399:
2370:
2327:
2292:
2241:
2212:
2161:
2126:
2083:
2045:
2008:
1979:
1936:
1888:
1847:
1798:
1757:
1703:
1651:
1602:
1558:
1500:
1464:
1428:
1222:
110:
58:
2644:
2523:
2488:
2453:
2391:
2360:
2352:
2317:
2282:
2274:
2233:
2202:
2194:
2151:
2116:
2108:
2075:
2037:
2000:
1969:
1928:
1878:
1837:
1788:
1747:
1739:
1693:
1641:
1594:
1550:
1492:
1456:
1420:
407:
338:
282:
237:
158:
2097:"Epstein-Barr virus immortalization: Notch2 interacts with CBF1 and blocks differentiation"
2140:"Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane"
1777:"Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane"
1256:
382:
1924:
41:
2287:
2262:
2512:"Phosphorylation of Ser2078 modulates the Notch2 function in 32D cell differentiation"
2278:
2207:
2183:"Notch1 and Notch2 inhibit myeloid differentiation in response to different cytokines"
2182:
2156:
2139:
2121:
2096:
1974:
1957:
1793:
1776:
848:
843:
838:
833:
828:
823:
818:
813:
808:
803:
798:
793:
788:
783:
778:
773:
768:
763:
758:
753:
748:
743:
738:
733:
728:
723:
718:
702:
697:
692:
687:
682:
677:
672:
667:
662:
657:
652:
647:
631:
626:
621:
2781:
2572:
2365:
2356:
2340:
2237:
1752:
1743:
1727:
1614:
1570:
1512:
1267:
608:
2411:
2253:
2173:
2112:
2057:
2020:
1948:
1810:
1663:
2699:
1294:
400:
179:
142:
1932:
166:
1397:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1379:
National Center for
Biotechnology Information, U.S. National Library of Medicine
483:
2004:
1251:
299:
196:
146:
2322:
2305:
1883:
1866:
878:
543:
421:
366:
353:
265:
252:
154:
2537:
2528:
2511:
2502:
2493:
2476:
2467:
2458:
2441:
2432:
2403:
2374:
2331:
2296:
2079:
2012:
1983:
1940:
1892:
1851:
1842:
1825:
1761:
1707:
1698:
1681:
1655:
1606:
1562:
1504:
1468:
1424:
2245:
2216:
2198:
2165:
2130:
2087:
2049:
1802:
1460:
1432:
1188:
1183:
1680:
Shimizu K, Chiba S, Saito T, Kumano K, Takahashi T, Hirai H (July 2001).
1172:
1023:
1004:
2761:
2751:
2577:
2567:
2477:"Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis"
2041:
1646:
1629:
1208:
990:
945:
87:
17:
2634:: Structure of LNR-HD (Negative Regulatory Region) from human Notch 2
1156:
900:
2440:
Shimizu K, Chiba S, Saito T, Kumano K, Takahashi T, Hirai H (2001).
1775:
Blaumueller CM, Qi H, Zagouras P, Artavanis-Tsakonas S (July 1997).
2510:
Inglés-Esteve J, Espinosa L, Milner LA, Caelles C, Bigas A (2002).
1598:
1554:
1496:
2395:
1299:
863:
859:
2735:
2730:
2709:
2704:
1824:
Espinosa L, Inglés-Esteve J, Aguilera C, Bigas A (August 2003).
1311:
1305:
1215:
134:
2648:
2587:
2138:
Blaumueller CM, Qi H, Zagouras P, Artavanis-Tsakonas S (1997).
588:
2583:
2562:
Overview of all the structural information available in the
1630:"Mutations in NOTCH2 in families with Hajdu-Cheney syndrome"
2095:
Hsieh JJ, Nofziger DE, Weinmaster G, Hayward SD (1997).
799:
transcription initiation from RNA polymerase II promoter
390:
744:
positive regulation of Ras protein signal transduction
121:, AGS2, HJCYS, hN2, Notch-2, notch 2, notch receptor 2
555:
2744:
2718:
2686:
1117:
1092:
1066:
1041:
2576:(Neurogenic locus notch homolog protein 2) at the
2553:GeneReviews/NCBI/UW/NIH entry on Alagille syndrome
2475:Saxena MT, Schroeter EH, Mumm JS, Kopan R (2001).
1527:"Entrez Gene: NOTCH2 Notch homolog 2 (Drosophila)"
1353:
1351:
1349:
1332:
1330:
1328:
844:positive regulation of keratinocyte proliferation
337:
236:
1721:
1719:
1717:
1675:
1673:
849:regulation of actin cytoskeleton reorganization
1358:GRCm38: Ensembl release 89: ENSMUSG00000027878
2660:
2599:
804:Notch signaling involved in heart development
8:
1274:have been shown to be the main cause of the
834:positive regulation of ERK1 and ERK2 cascade
1337:GRCh38: Ensembl release 89: ENSG00000134250
2667:
2653:
2645:
2606:
2592:
2584:
874:
739:regulation of transcription, DNA-templated
604:
378:
277:
174:
76:
2527:
2492:
2457:
2364:
2321:
2286:
2206:
2155:
2120:
1973:
1882:
1841:
1792:
1751:
1697:
1645:
1262:Mutations within the last coding exon of
1201:Neurogenic locus notch homolog protein 2
819:intracellular receptor signaling pathway
749:negative regulation of apoptotic process
2621:
1324:
2181:Bigas A, Martin DI, Milner LA (1998).
824:negative regulation of gene expression
31:
2263:"Human ligands of the Notch receptor"
683:integral component of plasma membrane
342:
303:
298:
241:
200:
195:
7:
839:regulation of osteoclast development
754:marginal zone B cell differentiation
1958:"Notch receptors and hematopoiesis"
784:regulation of developmental process
1114:
1089:
1063:
1038:
1014:
995:
969:
950:
924:
905:
829:negative regulation of growth rate
774:multicellular organism development
560:
478:
416:
395:
25:
2558:OMIM entries on Alagille syndrome
1211:that in humans is encoded by the
2624:
2357:10.1128/MCB.20.18.6913-6922.2000
2238:10.1097/00005072-199808000-00003
1744:10.1128/mcb.20.18.6913-6922.2000
769:stem cell population maintenance
578:
571:
564:
326:
319:
313:
290:
225:
218:
212:
187:
40:
2113:10.1128/JVI.71.3.1938-1945.1997
658:endoplasmic reticulum membrane
653:integral component of membrane
589:More reference expression data
544:More reference expression data
1:
2279:10.1016/S0002-9440(10)65325-4
2157:10.1016/S0092-8674(00)80336-0
1975:10.1016/S0301-472X(01)00676-2
1956:Kojika S, Griffin JD (2001).
1794:10.1016/s0092-8674(00)80336-0
734:pulmonary valve morphogenesis
514:vestibular sensory epithelium
311:
210:
1933:10.1126/science.284.5415.770
1272:nonsense-mediated mRNA decay
1243:type 1 transmembrane protein
759:transcription, DNA-templated
2788:Genes on human chromosome 1
2226:J. Neuropathol. Exp. Neurol
1237:Notch 2 is a member of the
779:atrial septum morphogenesis
632:signaling receptor activity
2804:
2745:Receptor on receiving cell
1221:NOTCH2 is associated with
794:animal organ morphogenesis
764:nervous system development
498:retinal pigment epithelium
432:retinal pigment epithelium
2619:
2005:10.1080/10428190400010742
1393:"Mouse PubMed Reference:"
1375:"Human PubMed Reference:"
1286:NOTCH2 has been shown to
1187:
1182:
1178:
1171:
1155:
1136:
1121:
1096:
1085:
1070:
1045:
1034:
1021:
1017:
1002:
998:
989:
976:
972:
957:
953:
944:
931:
927:
912:
908:
899:
884:
877:
873:
857:
607:
603:
586:
563:
554:
541:
490:
481:
428:
419:
389:
381:
377:
360:
347:
310:
289:
280:
276:
259:
246:
209:
186:
177:
173:
128:
125:
115:
108:
103:
84:
79:
62:
57:
52:
48:
39:
34:
2323:10.1074/jbc.274.46.32961
1884:10.1074/jbc.274.46.32961
1483:progressive bone loss".
1241:family. Members of this
1142:Chr 1: 119.91 – 120.1 Mb
2680:notch signaling pathway
1149:Chr 3: 97.92 – 98.06 Mb
814:cell fate determination
719:Notch signaling pathway
29:Protein found in humans
2529:10.1074/jbc.M104703200
2494:10.1074/jbc.M107234200
2459:10.1074/jbc.M103473200
2080:10.1006/geno.1996.0328
1843:10.1074/jbc.M304001200
1699:10.1074/jbc.M103473200
1425:10.1006/geno.1994.1613
1270:domain and escape the
344:3 F2.2|3 42.42 cM
2199:10.1128/mcb.18.4.2324
1461:10.1089/gte.2006.0519
1276:Hajdu–Cheney syndrome
1227:Hajdu–Cheney syndrome
724:cell differentiation
693:extracellular region
305:Chromosome 3 (mouse)
203:Chromosome 1 (human)
80:List of PDB id codes
53:Available structures
1925:1999Sci...284..770A
1257:trans-Golgi network
622:calcium ion binding
522:conjunctival fornix
2042:10.1038/ng1092-119
1647:10.1002/humu.21546
979:ENSMUSG00000027878
712:Biological process
641:Cellular component
615:Molecular function
526:epithelium of lens
464:tail of epididymis
167:NOTCH2 - orthologs
2775:
2774:
2690:on signaling cell
2676:Signaling pathway
2642:
2641:
1266:that remove the
1223:Alagille syndrome
1198:
1197:
1194:
1193:
1167:
1166:
1132:
1131:
1111:
1110:
1081:
1080:
1060:
1059:
1030:
1029:
1011:
1010:
985:
984:
966:
965:
940:
939:
921:
920:
869:
868:
809:apoptotic process
599:
598:
595:
594:
550:
549:
537:
536:
475:
474:
373:
372:
272:
271:
99:
98:
95:
94:
63:Ortholog search:
16:(Redirected from
2795:
2669:
2662:
2655:
2646:
2628:
2608:
2601:
2594:
2585:
2541:
2531:
2522:(48): 44873–80.
2506:
2496:
2487:(43): 40268–73.
2471:
2461:
2436:
2415:
2378:
2368:
2335:
2325:
2300:
2290:
2257:
2220:
2210:
2177:
2159:
2134:
2124:
2091:
2061:
2024:
1987:
1977:
1952:
1897:
1896:
1886:
1862:
1856:
1855:
1845:
1836:(34): 32227–35.
1821:
1815:
1814:
1796:
1772:
1766:
1765:
1755:
1723:
1712:
1711:
1701:
1677:
1668:
1667:
1649:
1625:
1619:
1618:
1581:
1575:
1574:
1537:
1531:
1530:
1523:
1517:
1516:
1479:
1473:
1472:
1443:
1437:
1436:
1407:
1401:
1400:
1389:
1383:
1382:
1371:
1365:
1355:
1344:
1334:
1180:
1179:
1151:
1144:
1127:
1115:
1106:
1090:
1086:RefSeq (protein)
1076:
1064:
1055:
1039:
1015:
996:
970:
951:
925:
906:
875:
673:receptor complex
605:
591:
582:
575:
568:
561:
546:
486:
484:Top expressed in
479:
460:lactiferous duct
452:caput epididymis
444:ventricular zone
424:
422:Top expressed in
417:
396:
379:
369:
356:
345:
330:
323:
317:
306:
294:
278:
268:
255:
244:
229:
222:
216:
205:
191:
175:
169:
120:
113:
90:
77:
71:
50:
49:
44:
32:
21:
2803:
2802:
2798:
2797:
2796:
2794:
2793:
2792:
2778:
2777:
2776:
2771:
2740:
2714:
2682:
2673:
2643:
2638:
2635:
2629:
2615:
2612:
2549:
2544:
2509:
2474:
2452:(28): 25753–8.
2439:
2418:
2381:
2351:(18): 6913–22.
2345:Mol. Cell. Biol
2338:
2316:(46): 32961–9.
2303:
2260:
2223:
2187:Mol. Cell. Biol
2180:
2137:
2094:
2064:
2027:
1990:
1955:
1919:(5415): 770–6.
1910:
1906:
1904:Further reading
1901:
1900:
1877:(46): 32961–9.
1864:
1863:
1859:
1823:
1822:
1818:
1774:
1773:
1769:
1738:(18): 6913–22.
1732:Mol. Cell. Biol
1725:
1724:
1715:
1692:(28): 25753–8.
1679:
1678:
1671:
1627:
1626:
1622:
1587:Nature Genetics
1583:
1582:
1578:
1543:Nature Genetics
1539:
1538:
1534:
1525:
1524:
1520:
1485:Nature Genetics
1481:
1480:
1476:
1445:
1444:
1440:
1409:
1408:
1404:
1391:
1390:
1386:
1373:
1372:
1368:
1356:
1347:
1335:
1326:
1321:
1284:
1235:
1189:View/Edit Mouse
1184:View/Edit Human
1147:
1140:
1137:Location (UCSC)
1123:
1102:
1098:
1072:
1051:
1047:
960:ENSG00000134250
853:
789:bone remodeling
707:
678:plasma membrane
636:
627:protein binding
587:
577:
576:
570:
569:
542:
533:
528:
524:
520:
516:
512:
508:
506:ascending aorta
504:
500:
496:
482:
471:
466:
462:
458:
454:
450:
446:
442:
438:
434:
420:
364:
351:
343:
333:
332:
331:
324:
304:
281:Gene location (
263:
250:
242:
232:
231:
230:
223:
201:
178:Gene location (
129:
116:
109:
86:
64:
30:
23:
22:
15:
12:
11:
5:
2801:
2799:
2791:
2790:
2780:
2779:
2773:
2772:
2770:
2769:
2764:
2759:
2754:
2748:
2746:
2742:
2741:
2739:
2738:
2733:
2728:
2724:
2722:
2716:
2715:
2713:
2712:
2707:
2702:
2697:
2693:
2691:
2684:
2683:
2674:
2672:
2671:
2664:
2657:
2649:
2640:
2639:
2637:
2636:
2630:
2623:
2620:
2617:
2616:
2613:
2611:
2610:
2603:
2596:
2588:
2582:
2581:
2560:
2555:
2548:
2547:External links
2545:
2543:
2542:
2507:
2472:
2437:
2416:
2379:
2336:
2301:
2258:
2221:
2193:(4): 2324–33.
2178:
2135:
2107:(3): 1938–45.
2092:
2062:
2025:
1993:Leuk. Lymphoma
1988:
1968:(9): 1041–52.
1953:
1907:
1905:
1902:
1899:
1898:
1857:
1816:
1767:
1713:
1669:
1640:(10): 1114–7.
1620:
1599:10.1038/ng.778
1576:
1555:10.1038/ng.779
1549:(4): 303–305.
1532:
1518:
1497:10.1038/ng.779
1474:
1438:
1402:
1384:
1366:
1345:
1323:
1322:
1320:
1317:
1316:
1315:
1309:
1303:
1297:
1283:
1280:
1234:
1231:
1196:
1195:
1192:
1191:
1186:
1176:
1175:
1169:
1168:
1165:
1164:
1162:
1160:
1153:
1152:
1145:
1138:
1134:
1133:
1130:
1129:
1119:
1118:
1112:
1109:
1108:
1094:
1093:
1087:
1083:
1082:
1079:
1078:
1068:
1067:
1061:
1058:
1057:
1043:
1042:
1036:
1032:
1031:
1028:
1027:
1019:
1018:
1012:
1009:
1008:
1000:
999:
993:
987:
986:
983:
982:
974:
973:
967:
964:
963:
955:
954:
948:
942:
941:
938:
937:
929:
928:
922:
919:
918:
910:
909:
903:
897:
896:
891:
886:
882:
881:
871:
870:
867:
866:
855:
854:
852:
851:
846:
841:
836:
831:
826:
821:
816:
811:
806:
801:
796:
791:
786:
781:
776:
771:
766:
761:
756:
751:
746:
741:
736:
731:
726:
721:
715:
713:
709:
708:
706:
705:
700:
695:
690:
685:
680:
675:
670:
668:Golgi membrane
665:
660:
655:
650:
644:
642:
638:
637:
635:
634:
629:
624:
618:
616:
612:
611:
601:
600:
597:
596:
593:
592:
584:
583:
558:
552:
551:
548:
547:
539:
538:
535:
534:
532:
531:
527:
523:
519:
515:
511:
507:
503:
499:
495:
491:
488:
487:
476:
473:
472:
470:
469:
465:
461:
457:
453:
449:
448:synovial joint
445:
441:
437:
433:
429:
426:
425:
413:
412:
404:
393:
387:
386:
383:RNA expression
375:
374:
371:
370:
362:
358:
357:
349:
346:
341:
335:
334:
325:
318:
312:
308:
307:
302:
296:
295:
287:
286:
274:
273:
270:
269:
261:
257:
256:
248:
245:
240:
234:
233:
224:
217:
211:
207:
206:
199:
193:
192:
184:
183:
171:
170:
127:
123:
122:
114:
106:
105:
101:
100:
97:
96:
93:
92:
82:
81:
73:
72:
61:
55:
54:
46:
45:
37:
36:
28:
24:
14:
13:
10:
9:
6:
4:
3:
2:
2800:
2789:
2786:
2785:
2783:
2768:
2765:
2763:
2760:
2758:
2755:
2753:
2750:
2749:
2747:
2743:
2737:
2734:
2732:
2729:
2726:
2725:
2723:
2721:
2717:
2711:
2708:
2706:
2703:
2701:
2698:
2695:
2694:
2692:
2689:
2685:
2681:
2677:
2670:
2665:
2663:
2658:
2656:
2651:
2650:
2647:
2633:
2627:
2622:
2618:
2609:
2604:
2602:
2597:
2595:
2590:
2589:
2586:
2579:
2575:
2574:
2569:
2565:
2561:
2559:
2556:
2554:
2551:
2550:
2546:
2539:
2535:
2530:
2525:
2521:
2517:
2516:J. Biol. Chem
2513:
2508:
2504:
2500:
2495:
2490:
2486:
2482:
2481:J. Biol. Chem
2478:
2473:
2469:
2465:
2460:
2455:
2451:
2447:
2446:J. Biol. Chem
2443:
2438:
2434:
2430:
2427:(7): 3200–5.
2426:
2422:
2417:
2413:
2409:
2405:
2401:
2397:
2396:10.1038/82644
2393:
2389:
2385:
2380:
2376:
2372:
2367:
2362:
2358:
2354:
2350:
2346:
2342:
2337:
2333:
2329:
2324:
2319:
2315:
2311:
2310:J. Biol. Chem
2307:
2302:
2298:
2294:
2289:
2284:
2280:
2276:
2273:(3): 785–94.
2272:
2268:
2267:Am. J. Pathol
2264:
2259:
2255:
2251:
2247:
2243:
2239:
2235:
2232:(8): 738–45.
2231:
2227:
2222:
2218:
2214:
2209:
2204:
2200:
2196:
2192:
2188:
2184:
2179:
2175:
2171:
2167:
2163:
2158:
2153:
2150:(2): 281–91.
2149:
2145:
2141:
2136:
2132:
2128:
2123:
2118:
2114:
2110:
2106:
2102:
2098:
2093:
2089:
2085:
2081:
2077:
2073:
2069:
2063:
2059:
2055:
2051:
2047:
2043:
2039:
2036:(2): 119–27.
2035:
2031:
2026:
2022:
2018:
2014:
2010:
2006:
2002:
1999:(2): 157–65.
1998:
1994:
1989:
1985:
1981:
1976:
1971:
1967:
1963:
1959:
1954:
1950:
1946:
1942:
1938:
1934:
1930:
1926:
1922:
1918:
1914:
1909:
1908:
1903:
1894:
1890:
1885:
1880:
1876:
1872:
1871:J. Biol. Chem
1868:
1861:
1858:
1853:
1849:
1844:
1839:
1835:
1831:
1830:J. Biol. Chem
1827:
1820:
1817:
1812:
1808:
1804:
1800:
1795:
1790:
1787:(2): 281–91.
1786:
1782:
1778:
1771:
1768:
1763:
1759:
1754:
1749:
1745:
1741:
1737:
1733:
1729:
1722:
1720:
1718:
1714:
1709:
1705:
1700:
1695:
1691:
1687:
1686:J. Biol. Chem
1683:
1676:
1674:
1670:
1665:
1661:
1657:
1653:
1648:
1643:
1639:
1635:
1631:
1624:
1621:
1616:
1612:
1608:
1604:
1600:
1596:
1592:
1588:
1580:
1577:
1572:
1568:
1564:
1560:
1556:
1552:
1548:
1544:
1536:
1533:
1528:
1522:
1519:
1514:
1510:
1506:
1502:
1498:
1494:
1490:
1486:
1478:
1475:
1470:
1466:
1462:
1458:
1455:(3): 216–27.
1454:
1450:
1442:
1439:
1434:
1430:
1426:
1422:
1418:
1414:
1406:
1403:
1398:
1394:
1388:
1385:
1380:
1376:
1370:
1367:
1363:
1359:
1354:
1352:
1350:
1346:
1342:
1338:
1333:
1331:
1329:
1325:
1318:
1313:
1310:
1307:
1304:
1301:
1298:
1296:
1293:
1292:
1291:
1289:
1281:
1279:
1277:
1273:
1269:
1265:
1260:
1258:
1254:
1253:
1248:
1244:
1240:
1232:
1230:
1228:
1224:
1219:
1217:
1214:
1210:
1206:
1202:
1190:
1185:
1181:
1177:
1174:
1170:
1163:
1161:
1158:
1154:
1150:
1146:
1143:
1139:
1135:
1128:
1126:
1120:
1116:
1113:
1107:
1105:
1101:
1095:
1091:
1088:
1084:
1077:
1075:
1069:
1065:
1062:
1056:
1054:
1050:
1044:
1040:
1037:
1035:RefSeq (mRNA)
1033:
1026:
1025:
1020:
1016:
1013:
1007:
1006:
1001:
997:
994:
992:
988:
981:
980:
975:
971:
968:
962:
961:
956:
952:
949:
947:
943:
936:
935:
930:
926:
923:
917:
916:
911:
907:
904:
902:
898:
895:
892:
890:
887:
883:
880:
876:
872:
865:
861:
856:
850:
847:
845:
842:
840:
837:
835:
832:
830:
827:
825:
822:
820:
817:
815:
812:
810:
807:
805:
802:
800:
797:
795:
792:
790:
787:
785:
782:
780:
777:
775:
772:
770:
767:
765:
762:
760:
757:
755:
752:
750:
747:
745:
742:
740:
737:
735:
732:
730:
727:
725:
722:
720:
717:
716:
714:
711:
710:
704:
701:
699:
696:
694:
691:
689:
686:
684:
681:
679:
676:
674:
671:
669:
666:
664:
661:
659:
656:
654:
651:
649:
646:
645:
643:
640:
639:
633:
630:
628:
625:
623:
620:
619:
617:
614:
613:
610:
609:Gene ontology
606:
602:
590:
585:
581:
574:
567:
562:
559:
557:
553:
545:
540:
529:
525:
521:
517:
513:
509:
505:
501:
497:
493:
492:
489:
485:
480:
477:
467:
463:
459:
455:
451:
447:
443:
440:skin of thigh
439:
435:
431:
430:
427:
423:
418:
415:
414:
411:
409:
405:
403:
402:
398:
397:
394:
392:
388:
384:
380:
376:
368:
363:
359:
355:
350:
340:
336:
329:
322:
316:
309:
301:
297:
293:
288:
284:
279:
275:
267:
262:
258:
254:
249:
239:
235:
228:
221:
215:
208:
204:
198:
194:
190:
185:
181:
176:
172:
168:
164:
160:
156:
152:
148:
144:
140:
136:
132:
124:
119:
112:
107:
102:
91:
89:
83:
78:
75:
74:
70:
67:
60:
56:
51:
47:
43:
38:
33:
27:
19:
2756:
2631:
2571:
2519:
2515:
2484:
2480:
2449:
2445:
2424:
2420:
2390:(4): 484–9.
2387:
2383:
2348:
2344:
2313:
2309:
2270:
2266:
2229:
2225:
2190:
2186:
2147:
2143:
2104:
2100:
2074:(1): 101–8.
2071:
2067:
2033:
2029:
1996:
1992:
1965:
1962:Exp. Hematol
1961:
1916:
1912:
1874:
1870:
1860:
1833:
1829:
1819:
1784:
1780:
1770:
1735:
1731:
1689:
1685:
1637:
1633:
1623:
1593:(4): 306–8.
1590:
1586:
1579:
1546:
1542:
1535:
1521:
1491:(4): 303–5.
1488:
1484:
1477:
1452:
1448:
1441:
1419:(2): 253–8.
1416:
1412:
1405:
1396:
1387:
1378:
1369:
1295:Delta-like 1
1285:
1282:Interactions
1263:
1261:
1250:
1236:
1220:
1212:
1204:
1200:
1199:
1122:
1100:NP_001186930
1097:
1071:
1049:NM_001200001
1046:
1022:
1003:
977:
958:
932:
913:
893:
888:
698:cell surface
518:cumulus cell
510:vas deferens
502:aortic valve
494:ciliary body
406:
399:
264:120,100,779
251:119,911,553
126:External IDs
85:
26:
2614:PDB gallery
1449:Genet. Test
729:hemopoiesis
688:nucleoplasm
468:skin of arm
436:skin of hip
365:98,057,677
352:97,920,843
104:Identifiers
2421:Cancer Res
2384:Nat. Genet
2030:Nat. Genet
1364:, May 2017
1343:, May 2017
1319:References
1252:Drosophila
410:(ortholog)
147:HomoloGene
1634:Hum Mutat
1615:205357384
1571:205357391
1513:205357391
1125:NP_035058
1104:NP_077719
1074:NM_010928
1053:NM_024408
879:Orthologs
648:cytoplasm
155:GeneCards
2782:Category
2688:Receptor
2538:11577080
2503:11518718
2468:11346656
2433:11306509
2412:23335042
2404:11101851
2375:10958687
2332:10551863
2297:10079256
2254:23509744
2174:16544864
2101:J. Virol
2068:Genomics
2058:32142845
2021:36863790
2013:15621797
1984:11532344
1949:16790253
1941:10221902
1893:10551863
1852:12794074
1811:16544864
1762:10958687
1708:11346656
1664:39342783
1656:21681853
1607:21378989
1563:21378985
1505:21378985
1469:17949281
1413:Genomics
1360:–
1339:–
1288:interact
1233:Function
1173:Wikidata
858:Sources:
663:membrane
2767:Notch 4
2762:Notch 3
2757:Notch 2
2752:Notch 1
2578:PDBe-KB
2568:UniProt
2288:1866435
2246:9720489
2217:9528802
2166:9244302
2131:9032325
2088:8661110
2050:1303260
1921:Bibcode
1913:Science
1803:9244302
1433:7698746
1362:Ensembl
1341:Ensembl
1209:protein
1207:) is a
1205:Notch 2
991:UniProt
946:Ensembl
885:Species
864:QuickGO
703:nucleus
385:pattern
111:Aliases
2727:Jagged
2720:Ligand
2573:Q04721
2536:
2501:
2466:
2431:
2410:
2402:
2373:
2363:
2330:
2295:
2285:
2252:
2244:
2215:
2208:121486
2205:
2172:
2164:
2129:
2122:191274
2119:
2086:
2056:
2048:
2019:
2011:
1982:
1947:
1939:
1891:
1850:
1809:
1801:
1760:
1750:
1706:
1662:
1654:
1613:
1605:
1569:
1561:
1511:
1503:
1467:
1431:
1308:, and
1290:with:
1264:Notch2
1213:NOTCH2
1159:search
1157:PubMed
1024:O35516
1005:Q04721
901:Entrez
556:BioGPS
159:NOTCH2
135:600275
118:NOTCH2
35:NOTCH2
18:NOTCH2
2696:Delta
2408:S2CID
2366:88767
2250:S2CID
2170:S2CID
2054:S2CID
2017:S2CID
1945:S2CID
1807:S2CID
1753:88767
1660:S2CID
1611:S2CID
1567:S2CID
1509:S2CID
1300:GSK3B
1239:notch
934:18129
894:Mouse
889:Human
860:Amigo
530:molar
456:vulva
408:Mouse
401:Human
348:Start
283:Mouse
247:Start
180:Human
143:97364
2736:JAG2
2731:JAG1
2710:DLL4
2705:DLL3
2700:DLL1
2632:2oo4
2566:for
2534:PMID
2499:PMID
2464:PMID
2429:PMID
2400:PMID
2371:PMID
2328:PMID
2293:PMID
2242:PMID
2213:PMID
2162:PMID
2144:Cell
2127:PMID
2084:PMID
2046:PMID
2009:PMID
1980:PMID
1937:PMID
1889:PMID
1848:PMID
1799:PMID
1781:Cell
1758:PMID
1704:PMID
1652:PMID
1603:PMID
1559:PMID
1501:PMID
1465:PMID
1429:PMID
1312:JAG2
1306:JAG1
1268:PEST
1225:and
1216:gene
915:4853
391:Bgee
339:Band
300:Chr.
243:1p12
238:Band
197:Chr.
151:7865
131:OMIM
88:2OO4
69:RCSB
66:PDBe
2564:PDB
2524:doi
2520:276
2489:doi
2485:276
2454:doi
2450:276
2392:doi
2361:PMC
2353:doi
2318:doi
2314:274
2283:PMC
2275:doi
2271:154
2234:doi
2203:PMC
2195:doi
2152:doi
2117:PMC
2109:doi
2076:doi
2038:doi
2001:doi
1970:doi
1929:doi
1917:284
1879:doi
1875:274
1838:doi
1834:278
1789:doi
1748:PMC
1740:doi
1694:doi
1690:276
1642:doi
1595:doi
1551:doi
1493:doi
1457:doi
1421:doi
1247:EGF
361:End
260:End
163:OMA
139:MGI
59:PDB
2784::
2678::
2570::
2532:.
2518:.
2514:.
2497:.
2483:.
2479:.
2462:.
2448:.
2444:.
2425:61
2423:.
2406:.
2398:.
2388:26
2386:.
2369:.
2359:.
2349:20
2347:.
2343:.
2326:.
2312:.
2308:.
2291:.
2281:.
2269:.
2265:.
2248:.
2240:.
2230:57
2228:.
2211:.
2201:.
2191:18
2189:.
2185:.
2168:.
2160:.
2148:90
2146:.
2142:.
2125:.
2115:.
2105:71
2103:.
2099:.
2082:.
2072:35
2070:.
2052:.
2044:.
2032:.
2015:.
2007:.
1997:46
1995:.
1978:.
1966:29
1964:.
1960:.
1943:.
1935:.
1927:.
1915:.
1887:.
1873:.
1869:.
1846:.
1832:.
1828:.
1805:.
1797:.
1785:90
1783:.
1779:.
1756:.
1746:.
1736:20
1734:.
1730:.
1716:^
1702:.
1688:.
1684:.
1672:^
1658:.
1650:.
1638:32
1636:.
1632:.
1609:.
1601:.
1591:43
1589:.
1565:.
1557:.
1547:43
1545:.
1507:.
1499:.
1489:43
1487:.
1463:.
1453:11
1451:.
1427:.
1417:24
1415:.
1395:.
1377:.
1348:^
1327:^
1278:.
1229:.
1218:.
862:/
367:bp
354:bp
266:bp
253:bp
161:;
157::
153:;
149::
145:;
141::
137:;
133::
2668:e
2661:t
2654:v
2607:e
2600:t
2593:v
2580:.
2540:.
2526::
2505:.
2491::
2470:.
2456::
2435:.
2414:.
2394::
2377:.
2355::
2334:.
2320::
2299:.
2277::
2256:.
2236::
2219:.
2197::
2176:.
2154::
2133:.
2111::
2090:.
2078::
2060:.
2040::
2034:2
2023:.
2003::
1986:.
1972::
1951:.
1931::
1923::
1895:.
1881::
1854:.
1840::
1813:.
1791::
1764:.
1742::
1710:.
1696::
1666:.
1644::
1617:.
1597::
1573:.
1553::
1529:.
1515:.
1495::
1471:.
1459::
1435:.
1423::
1399:.
1381:.
1314:.
1302:,
1203:(
285:)
182:)
165::
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
