1378:
kD precursor protein. This cleavage results in the 98 kD nucleoporin as well as a 96 kD nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the
Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.
322:
299:
196:
221:
580:
573:
2719:
328:
227:
29:
1377:
Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is composed of approximately 30 unique proteins collectively known as nucleoporins. The 98 kD nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186
2046:
Borrow J, Shearman AM, Stanton VP, Becher R, Collins T, Williams AJ, Dubé I, Katz F, Kwong YL, Morris C, Ohyashiki K, Toyama K, Rowley J, Housman DE (1996). "The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9".
2008:
Nakamura T, Largaespada DA, Lee MP, Johnson LA, Ohyashiki K, Toyama K, Chen SJ, Willman CL, Chen IM, Feinberg AP, Jenkins NA, Copeland NG, Shaughnessy JD (1996). "Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia".
55:
1519:"The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10"
2491:
Ahuja HG, Felix CA, Aplan PD (1999). "The t(11;20)(p15;q11) chromosomal translocation associated with therapy-related myelodysplastic syndrome results in an NUP98-TOP1 fusion".
2784:
2635:"Cofactor requirements for nuclear export of Rev response element (RRE)- and constitutive transport element (CTE)-containing retroviral RNAs. An unexpected role for actin"
335:
234:
2718:
988:
2407:"A conserved biogenesis pathway for nucleoporins: proteolytic processing of a 186-kilodalton precursor generates Nup98 and the novel nucleoporin, Nup96"
157:
969:
2759:
2278:"Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assembly"
1499:
3007:
2698:
1481:
52:
321:
2633:
Hofmann W, Reichart B, Ewald A, Müller E, Schmitt I, Stauber RH, Lottspeich F, Jockusch BM, Scheer U, Hauber J, Dabauvalle MC (2001).
2364:"CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity"
1574:"CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity"
1303:
2520:
Bachi A, Braun IC, Rodrigues JP, Panté N, Ribbeck K, von Kobbe C, Kutay U, Wilm M, Görlich D, Carmo-Fonseca M, Izaurralde E (2000).
2450:"RAE1 is a shuttling mRNA export factor that binds to a GLEBS-like NUP98 motif at the nuclear pore complex through multiple domains"
1920:
Moore MA, Chung KY, Plasilova M, Schuringa JJ, Shieh JH, Zhou P, Morrone G (2007). "NUP98 dysregulation in myeloid leukemogenesis".
1790:"RAE1 is a shuttling mRNA export factor that binds to a GLEBS-like NUP98 motif at the nuclear pore complex through multiple domains"
1296:
298:
2941:
2522:"The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates"
1558:
2129:"A role for nucleoporin FG repeat domains in export of human immunodeficiency virus type 1 Rev protein and RNA from the nucleus"
1468:
1447:
1741:"Nup98 localizes to both nuclear and cytoplasmic sides of the nuclear pore and binds to two distinct nucleoporin subcomplexes"
220:
195:
1464:
2565:"The nucleoporin Nup98 is a site for GDP/GTP exchange on ran and termination of karyopherin beta 2-mediated nuclear import"
1839:"The nucleoporin Nup98 is a site for GDP/GTP exchange on ran and termination of karyopherin beta 2-mediated nuclear import"
3012:
2812:
1967:"The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complex"
1443:
137:
1387:
334:
233:
2789:
2752:
327:
226:
2691:
2600:"Vesicular stomatitis virus matrix protein inhibits host cell gene expression by targeting the nucleoporin Nup98"
2086:"Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins"
1033:
145:
2817:
1014:
2794:
1623:"RanGTP-mediated nuclear export of karyopherin alpha involves its interaction with the nucleoporin Nup153"
2976:
2745:
2321:"Nucleoporins nup98 and nup214 participate in nuclear export of human immunodeficiency virus type 1 Rev"
209:
2684:
2236:
2183:
1929:
1693:
1634:
1394:
124:
1279:
1275:
1271:
1267:
1263:
1259:
1255:
1251:
1237:
1233:
1229:
1225:
1210:
1206:
1202:
1198:
1188:
1148:
1144:
1140:
1136:
2915:
2072:
2034:
1996:
1953:
1908:
169:
1241:
1184:
1180:
1176:
1172:
1152:
1115:
1111:
1107:
1103:
2664:
2621:
2586:
2551:
2508:
2479:
2436:
2393:
2350:
2307:
2264:
2211:
2158:
2115:
2064:
2026:
1988:
1945:
1900:
1860:
1819:
1770:
1721:
1662:
1603:
1540:
579:
572:
117:
45:
2951:
2804:
2654:
2646:
2611:
2576:
2541:
2533:
2500:
2469:
2461:
2426:
2418:
2383:
2375:
2340:
2332:
2297:
2289:
2254:
2244:
2201:
2191:
2148:
2140:
2105:
2097:
2056:
2018:
1978:
1937:
1892:
1850:
1809:
1801:
1760:
1752:
1711:
1701:
1652:
1642:
1593:
1585:
1572:
Kasper LH, Brindle PK, Schnabel CA, Pritchard CE, Cleary ML, van
Deursen JM (January 1999).
1530:
414:
345:
289:
244:
165:
2925:
2920:
2910:
2905:
2900:
2895:
2890:
2885:
1517:
Arai Y, Hosoda F, Kobayashi H, Arai K, Hayashi Y, Kamada N, Kaneko Y, Ohki M (June 1997).
389:
2598:
Rodrigues JP, Sitterlin D, Bachi A, Wu X, Wilm M, Carmo-Fonseca M, Izaurralde E (2000).
2240:
2187:
1933:
1697:
1638:
2875:
2870:
2865:
2860:
2855:
2850:
2845:
2840:
2835:
2659:
2634:
2546:
2521:
2474:
2449:
2431:
2406:
2110:
2085:
1814:
1789:
28:
2616:
2599:
2345:
2320:
2153:
2128:
1883:
Slape C, Aplan PD (2004). "The role of NUP98 gene fusions in hematologic malignancy".
1765:
1740:
903:
898:
893:
888:
883:
878:
873:
868:
863:
858:
853:
848:
843:
838:
833:
828:
823:
818:
813:
808:
803:
798:
793:
788:
772:
767:
762:
757:
752:
747:
742:
737:
732:
727:
722:
717:
712:
707:
702:
697:
692:
676:
671:
666:
661:
656:
651:
646:
641:
636:
631:
626:
621:
3001:
2986:
2776:
2388:
2363:
2302:
2277:
2259:
2224:
2206:
2171:
1983:
1966:
1716:
1681:
1657:
1622:
1598:
1573:
608:
2362:
Kasper LH, Brindle PK, Schnabel CA, Pritchard CE, Cleary ML, van
Deursen JM (1999).
2076:
2000:
1957:
1912:
2971:
2768:
2038:
407:
186:
149:
2336:
1896:
173:
2956:
2827:
1504:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1486:
National Center for
Biotechnology Information, U.S. National Library of Medicine
819:
posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery
490:
2961:
2537:
1535:
1518:
306:
203:
153:
2727:: Crystal Structure of C-terminal Autoproteolytic Domain of Nucleoporin Nup98
2504:
2966:
2249:
1941:
1756:
1706:
1647:
933:
550:
428:
373:
360:
272:
259:
161:
2668:
2625:
2590:
2581:
2564:
2555:
2512:
2483:
2440:
2422:
2196:
2144:
1949:
1904:
1864:
1855:
1838:
1823:
1774:
2650:
2465:
2397:
2354:
2311:
2293:
2268:
2215:
2162:
2119:
2101:
2068:
2030:
1992:
1805:
1725:
1666:
1607:
1544:
1343:
1338:
2981:
2379:
2276:
Grandi P, Dang T, Pané N, Shevchenko A, Mann M, Forbes D, Hurt E (1997).
1589:
1327:
1078:
1059:
2060:
2022:
1359:
1045:
1000:
94:
90:
86:
82:
78:
74:
2225:"Karyopherin beta2 mediates nuclear import of a mRNA binding protein"
1682:"Karyopherin beta2 mediates nuclear import of a mRNA binding protein"
1311:
955:
2946:
1788:
Pritchard CE, Fornerod M, Kasper LH, van
Deursen JM (April 1999).
1418:
1406:
1400:
918:
914:
1412:
1366:
141:
2741:
2737:
2680:
588:
2676:
2448:
Pritchard CE, Fornerod M, Kasper LH, van
Deursen JM (1999).
869:
positive regulation of nucleic acid-templated transcription
2172:"Cloning and characterization of human karyopherin beta3"
849:
positive regulation of transcription by RNA polymerase II
128:, ADIR2, NUP196, NUP96, nucleoporin 98kDa, nucleoporin 98
397:
1680:
Bonifaci N, Moroianu J, Radu A, Blobel G (May 1997).
854:
positive regulation of mRNA splicing, via spliceosome
562:
2785:
Branched-chain alpha-keto acid dehydrogenase complex
2127:
Stutz F, Izaurralde E, Mattaj IW, Rosbash M (1996).
2934:
2826:
2803:
2775:
1224:
1171:
1129:
1096:
1460:
1458:
1456:
1439:
1437:
1435:
2223:Bonifaci N, Moroianu J, Radu A, Blobel G (1997).
1837:Fontoura BM, Blobel G, Yaseen NR (October 2000).
344:
243:
1621:Moroianu J, Blobel G, Radu A (September 1997).
16:Protein-coding gene in the species Homo sapiens
1465:GRCm38: Ensembl release 89: ENSMUSG00000063550
2753:
2692:
1739:Griffis ER, Xu S, Powers MA (February 2003).
8:
1444:GRCh38: Ensembl release 89: ENSG00000110713
2760:
2746:
2738:
2699:
2685:
2677:
2405:Fontoura BM, Blobel G, Matunis MJ (1999).
1221:
1168:
929:
604:
385:
284:
181:
63:
2658:
2615:
2580:
2563:Fontoura BM, Blobel G, Yaseen NR (2000).
2545:
2473:
2430:
2387:
2344:
2301:
2258:
2248:
2205:
2195:
2152:
2109:
1982:
1854:
1813:
1764:
1715:
1705:
1656:
1646:
1597:
1534:
1356:Nuclear pore complex protein Nup98-Nup96
758:intracellular membrane-bounded organelle
2714:
1431:
904:regulation of cellular response to heat
829:telomere tethering at nuclear periphery
1559:"Entrez Gene: NUP98 nucleoporin 98kDa"
677:structural constituent of nuclear pore
18:
894:regulation of gene silencing by miRNA
637:nuclear localization sequence binding
349:
310:
305:
248:
207:
202:
7:
517:vestibular membrane of cochlear duct
1965:Radu A, Moore MS, Blobel G (1995).
672:promoter-specific chromatin binding
1126:
1093:
1069:
1050:
1024:
1005:
979:
960:
859:transcription by RNA polymerase II
748:nuclear pore cytoplasmic filaments
662:transcription coactivator activity
567:
485:
423:
402:
14:
2319:Zolotukhin AS, Felber BK (1999).
1362:that in humans is encoded by the
2717:
899:intracellular transport of virus
874:regulation of glycolytic process
578:
571:
333:
326:
320:
297:
232:
225:
219:
194:
27:
2084:Hu T, Guan T, Gerace L (1996).
652:serine-type peptidase activity
589:More reference expression data
551:More reference expression data
1:
2617:10.1016/S1097-2765(00)00120-9
2337:10.1128/JVI.73.1.120-127.1999
794:nuclear pore complex assembly
318:
217:
3008:Genes on human chromosome 11
2229:Proc. Natl. Acad. Sci. U.S.A
2176:Proc. Natl. Acad. Sci. U.S.A
2170:Yaseen NR, Blobel G (1997).
1984:10.1016/0092-8674(95)90331-3
1897:10.1080/10428190310001659325
1686:Proc. Natl. Acad. Sci. U.S.A
1627:Proc. Natl. Acad. Sci. U.S.A
864:nucleocytoplasmic transport
839:protein import into nucleus
733:nuclear pore nuclear basket
3029:
2813:Epidermal transglutaminase
2790:Oxoglutarate dehydrogenase
2712:
2538:10.1017/S1355838200991994
1536:10.1182/blood.V89.11.3936
1500:"Mouse PubMed Reference:"
1482:"Human PubMed Reference:"
1342:
1337:
1333:
1326:
1310:
1304:Chr 7: 101.77 – 101.86 Mb
1291:
1248:
1195:
1164:
1133:
1100:
1089:
1076:
1072:
1057:
1053:
1044:
1031:
1027:
1012:
1008:
999:
986:
982:
967:
963:
954:
939:
932:
928:
912:
814:nuclear pore organization
768:ribonucleoprotein complex
607:
603:
586:
570:
561:
548:
497:
488:
435:
426:
396:
388:
384:
367:
354:
317:
296:
287:
283:
266:
253:
216:
193:
184:
180:
135:
132:
122:
115:
110:
71:
66:
49:
44:
39:
35:
26:
21:
2967:Filaggrin (Citrullinate)
2505:10.1182/blood.V94.9.3258
1386:NUP98 has been shown to
879:tRNA export from nucleus
834:mRNA export from nucleus
2818:Tissue transglutaminase
2250:10.1073/pnas.94.10.5055
1942:10.1196/annals.1392.019
1757:10.1091/mbc.E02-09-0582
1707:10.1073/pnas.94.10.5055
1648:10.1073/pnas.94.18.9699
824:RNA export from nucleus
723:nuclear pore outer ring
529:external carotid artery
525:internal carotid artery
475:upper lobe of left lung
2942:Acetylcholine receptor
2795:Pyruvate dehydrogenase
2582:10.1074/jbc.M004651200
2423:10.1083/jcb.144.6.1097
2197:10.1073/pnas.94.9.4451
2145:10.1128/mcb.16.12.7144
1856:10.1074/jbc.M004651200
728:nuclear inclusion body
2977:Sp100 nuclear antigen
2651:10.1083/jcb.152.5.895
2466:10.1083/jcb.145.2.237
2294:10.1091/mbc.8.10.2017
2102:10.1083/jcb.134.3.589
1806:10.1083/jcb.145.2.237
1297:Chr 11: 3.67 – 3.8 Mb
210:Chromosome 11 (human)
3013:Nuclear pore complex
2380:10.1128/mcb.19.1.764
1922:Ann. N. Y. Acad. Sci
1590:10.1128/mcb.19.1.764
1395:CREB-binding protein
622:transporter activity
351:7 E2|7 54.71 cM
312:Chromosome 7 (mouse)
67:List of PDB id codes
40:Available structures
2241:1997PNAS...94.5055B
2188:1997PNAS...94.4451Y
1934:2007NYASA1106..114M
1698:1997PNAS...94.5055B
1639:1997PNAS...94.9699M
889:viral transcription
884:protein sumoylation
447:epithelium of colon
2061:10.1038/ng0296-159
2023:10.1038/ng0296-154
1034:ENSMUSG00000063550
782:Biological process
686:Cellular component
657:hydrolase activity
647:peptidase activity
615:Molecular function
2995:
2994:
2735:
2734:
1353:
1352:
1349:
1348:
1322:
1321:
1287:
1286:
1218:
1217:
1160:
1159:
1123:
1122:
1085:
1084:
1066:
1065:
1040:
1039:
1021:
1020:
995:
994:
976:
975:
924:
923:
804:protein transport
708:nuclear periphery
599:
598:
595:
594:
557:
556:
544:
543:
482:
481:
471:left uterine tube
380:
379:
279:
278:
174:NUP98 - orthologs
106:
105:
102:
101:
50:Ortholog search:
3020:
2952:Apolipoprotein H
2805:Transglutaminase
2762:
2755:
2748:
2739:
2721:
2701:
2694:
2687:
2678:
2672:
2662:
2629:
2619:
2594:
2584:
2575:(40): 31289–96.
2559:
2549:
2516:
2487:
2477:
2444:
2434:
2401:
2391:
2358:
2348:
2315:
2305:
2272:
2262:
2252:
2219:
2209:
2199:
2166:
2156:
2123:
2113:
2080:
2042:
2004:
1986:
1961:
1916:
1869:
1868:
1858:
1849:(40): 31289–96.
1834:
1828:
1827:
1817:
1785:
1779:
1778:
1768:
1736:
1730:
1729:
1719:
1709:
1677:
1671:
1670:
1660:
1650:
1633:(18): 9699–704.
1618:
1612:
1611:
1601:
1569:
1563:
1562:
1555:
1549:
1548:
1538:
1514:
1508:
1507:
1496:
1490:
1489:
1478:
1472:
1462:
1451:
1441:
1335:
1334:
1306:
1299:
1282:
1222:
1213:
1169:
1165:RefSeq (protein)
1155:
1127:
1118:
1094:
1070:
1051:
1025:
1006:
980:
961:
930:
703:nuclear envelope
698:nuclear membrane
605:
591:
582:
575:
568:
553:
537:genital tubercle
501:secondary oocyte
493:
491:Top expressed in
486:
455:ventricular zone
451:secondary oocyte
431:
429:Top expressed in
424:
403:
386:
376:
363:
352:
337:
330:
324:
313:
301:
285:
275:
262:
251:
236:
229:
223:
212:
198:
182:
176:
127:
120:
97:
64:
58:
37:
36:
31:
19:
3028:
3027:
3023:
3022:
3021:
3019:
3018:
3017:
2998:
2997:
2996:
2991:
2930:
2822:
2799:
2771:
2766:
2736:
2731:
2728:
2722:
2708:
2705:
2675:
2632:
2597:
2562:
2519:
2490:
2447:
2417:(6): 1097–112.
2404:
2368:Mol. Cell. Biol
2361:
2318:
2288:(10): 2017–38.
2282:Mol. Biol. Cell
2275:
2235:(10): 5055–60.
2222:
2169:
2139:(12): 7144–50.
2133:Mol. Cell. Biol
2126:
2083:
2045:
2007:
1964:
1919:
1882:
1878:
1876:Further reading
1873:
1872:
1836:
1835:
1831:
1787:
1786:
1782:
1745:Mol. Biol. Cell
1738:
1737:
1733:
1692:(10): 5055–60.
1679:
1678:
1674:
1620:
1619:
1615:
1578:Mol. Cell. Biol
1571:
1570:
1566:
1557:
1556:
1552:
1529:(11): 3936–44.
1516:
1515:
1511:
1498:
1497:
1493:
1480:
1479:
1475:
1463:
1454:
1442:
1433:
1428:
1384:
1375:
1344:View/Edit Mouse
1339:View/Edit Human
1302:
1295:
1292:Location (UCSC)
1278:
1274:
1270:
1266:
1262:
1258:
1254:
1250:
1244:
1240:
1236:
1232:
1228:
1209:
1205:
1201:
1197:
1191:
1187:
1183:
1179:
1175:
1151:
1147:
1143:
1139:
1135:
1114:
1110:
1106:
1102:
1015:ENSG00000110713
908:
799:DNA replication
777:
681:
632:protein binding
627:peptide binding
587:
577:
576:
549:
540:
535:
531:
527:
523:
519:
515:
511:
507:
503:
489:
478:
473:
469:
467:Achilles tendon
465:
461:
459:muscle of thigh
457:
453:
449:
445:
441:
427:
371:
358:
350:
340:
339:
338:
331:
311:
288:Gene location (
270:
257:
249:
239:
238:
237:
230:
208:
185:Gene location (
136:
123:
116:
73:
51:
17:
12:
11:
5:
3026:
3024:
3016:
3015:
3010:
3000:
2999:
2993:
2992:
2990:
2989:
2984:
2979:
2974:
2969:
2964:
2959:
2954:
2949:
2944:
2938:
2936:
2932:
2931:
2929:
2928:
2923:
2918:
2913:
2908:
2903:
2898:
2893:
2888:
2883:
2878:
2873:
2868:
2863:
2858:
2853:
2848:
2843:
2838:
2832:
2830:
2824:
2823:
2821:
2820:
2815:
2809:
2807:
2801:
2800:
2798:
2797:
2792:
2787:
2781:
2779:
2773:
2772:
2767:
2765:
2764:
2757:
2750:
2742:
2733:
2732:
2730:
2729:
2723:
2716:
2713:
2710:
2709:
2706:
2704:
2703:
2696:
2689:
2681:
2674:
2673:
2645:(5): 895–910.
2630:
2610:(5): 1243–52.
2595:
2560:
2517:
2499:(9): 3258–61.
2488:
2445:
2402:
2359:
2316:
2273:
2220:
2167:
2124:
2096:(3): 589–601.
2081:
2043:
2005:
1962:
1917:
1891:(7): 1341–50.
1885:Leuk. Lymphoma
1879:
1877:
1874:
1871:
1870:
1829:
1780:
1731:
1672:
1613:
1564:
1550:
1509:
1491:
1473:
1452:
1430:
1429:
1427:
1424:
1423:
1422:
1416:
1410:
1404:
1398:
1383:
1380:
1374:
1371:
1351:
1350:
1347:
1346:
1341:
1331:
1330:
1324:
1323:
1320:
1319:
1317:
1315:
1308:
1307:
1300:
1293:
1289:
1288:
1285:
1284:
1246:
1245:
1219:
1216:
1215:
1193:
1192:
1166:
1162:
1161:
1158:
1157:
1131:
1130:
1124:
1121:
1120:
1098:
1097:
1091:
1087:
1086:
1083:
1082:
1074:
1073:
1067:
1064:
1063:
1055:
1054:
1048:
1042:
1041:
1038:
1037:
1029:
1028:
1022:
1019:
1018:
1010:
1009:
1003:
997:
996:
993:
992:
984:
983:
977:
974:
973:
965:
964:
958:
952:
951:
946:
941:
937:
936:
926:
925:
922:
921:
910:
909:
907:
906:
901:
896:
891:
886:
881:
876:
871:
866:
861:
856:
851:
846:
841:
836:
831:
826:
821:
816:
811:
806:
801:
796:
791:
789:mRNA transport
785:
783:
779:
778:
776:
775:
770:
765:
760:
755:
750:
745:
740:
735:
730:
725:
720:
715:
710:
705:
700:
695:
689:
687:
683:
682:
680:
679:
674:
669:
664:
659:
654:
649:
644:
639:
634:
629:
624:
618:
616:
612:
611:
601:
600:
597:
596:
593:
592:
584:
583:
565:
559:
558:
555:
554:
546:
545:
542:
541:
539:
538:
534:
530:
526:
522:
521:tail of embryo
518:
514:
513:primary oocyte
510:
506:
502:
498:
495:
494:
483:
480:
479:
477:
476:
472:
468:
464:
460:
456:
452:
448:
444:
440:
436:
433:
432:
420:
419:
411:
400:
394:
393:
390:RNA expression
382:
381:
378:
377:
369:
365:
364:
356:
353:
348:
342:
341:
332:
325:
319:
315:
314:
309:
303:
302:
294:
293:
281:
280:
277:
276:
268:
264:
263:
255:
252:
247:
241:
240:
231:
224:
218:
214:
213:
206:
200:
199:
191:
190:
178:
177:
134:
130:
129:
121:
113:
112:
108:
107:
104:
103:
100:
99:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
3025:
3014:
3011:
3009:
3006:
3005:
3003:
2988:
2987:Topoisomerase
2985:
2983:
2980:
2978:
2975:
2973:
2970:
2968:
2965:
2963:
2960:
2958:
2955:
2953:
2950:
2948:
2945:
2943:
2940:
2939:
2937:
2933:
2927:
2924:
2922:
2919:
2917:
2914:
2912:
2909:
2907:
2904:
2902:
2899:
2897:
2894:
2892:
2889:
2887:
2884:
2882:
2879:
2877:
2874:
2872:
2869:
2867:
2864:
2862:
2859:
2857:
2854:
2852:
2849:
2847:
2844:
2842:
2839:
2837:
2834:
2833:
2831:
2829:
2825:
2819:
2816:
2814:
2811:
2810:
2808:
2806:
2802:
2796:
2793:
2791:
2788:
2786:
2783:
2782:
2780:
2778:
2777:Dehydrogenase
2774:
2770:
2763:
2758:
2756:
2751:
2749:
2744:
2743:
2740:
2726:
2720:
2715:
2711:
2702:
2697:
2695:
2690:
2688:
2683:
2682:
2679:
2670:
2666:
2661:
2656:
2652:
2648:
2644:
2640:
2636:
2631:
2627:
2623:
2618:
2613:
2609:
2605:
2601:
2596:
2592:
2588:
2583:
2578:
2574:
2570:
2569:J. Biol. Chem
2566:
2561:
2557:
2553:
2548:
2543:
2539:
2535:
2532:(1): 136–58.
2531:
2527:
2523:
2518:
2514:
2510:
2506:
2502:
2498:
2494:
2489:
2485:
2481:
2476:
2471:
2467:
2463:
2460:(2): 237–54.
2459:
2455:
2451:
2446:
2442:
2438:
2433:
2428:
2424:
2420:
2416:
2412:
2408:
2403:
2399:
2395:
2390:
2385:
2381:
2377:
2374:(1): 764–76.
2373:
2369:
2365:
2360:
2356:
2352:
2347:
2342:
2338:
2334:
2330:
2326:
2322:
2317:
2313:
2309:
2304:
2299:
2295:
2291:
2287:
2283:
2279:
2274:
2270:
2266:
2261:
2256:
2251:
2246:
2242:
2238:
2234:
2230:
2226:
2221:
2217:
2213:
2208:
2203:
2198:
2193:
2189:
2185:
2182:(9): 4451–6.
2181:
2177:
2173:
2168:
2164:
2160:
2155:
2150:
2146:
2142:
2138:
2134:
2130:
2125:
2121:
2117:
2112:
2107:
2103:
2099:
2095:
2091:
2087:
2082:
2078:
2074:
2070:
2066:
2062:
2058:
2055:(2): 159–67.
2054:
2050:
2044:
2040:
2036:
2032:
2028:
2024:
2020:
2016:
2012:
2006:
2002:
1998:
1994:
1990:
1985:
1980:
1977:(2): 215–22.
1976:
1972:
1968:
1963:
1959:
1955:
1951:
1947:
1943:
1939:
1935:
1931:
1928:(1): 114–42.
1927:
1923:
1918:
1914:
1910:
1906:
1902:
1898:
1894:
1890:
1886:
1881:
1880:
1875:
1866:
1862:
1857:
1852:
1848:
1844:
1843:J. Biol. Chem
1840:
1833:
1830:
1825:
1821:
1816:
1811:
1807:
1803:
1800:(2): 237–54.
1799:
1795:
1791:
1784:
1781:
1776:
1772:
1767:
1762:
1758:
1754:
1751:(2): 600–10.
1750:
1746:
1742:
1735:
1732:
1727:
1723:
1718:
1713:
1708:
1703:
1699:
1695:
1691:
1687:
1683:
1676:
1673:
1668:
1664:
1659:
1654:
1649:
1644:
1640:
1636:
1632:
1628:
1624:
1617:
1614:
1609:
1605:
1600:
1595:
1591:
1587:
1584:(1): 764–76.
1583:
1579:
1575:
1568:
1565:
1560:
1554:
1551:
1546:
1542:
1537:
1532:
1528:
1524:
1520:
1513:
1510:
1505:
1501:
1495:
1492:
1487:
1483:
1477:
1474:
1470:
1466:
1461:
1459:
1457:
1453:
1449:
1445:
1440:
1438:
1436:
1432:
1425:
1420:
1417:
1414:
1411:
1408:
1405:
1402:
1399:
1396:
1393:
1392:
1391:
1389:
1381:
1379:
1372:
1370:
1368:
1365:
1361:
1357:
1345:
1340:
1336:
1332:
1329:
1325:
1318:
1316:
1313:
1309:
1305:
1301:
1298:
1294:
1290:
1283:
1281:
1277:
1273:
1269:
1265:
1261:
1257:
1253:
1247:
1243:
1239:
1235:
1231:
1227:
1223:
1220:
1214:
1212:
1208:
1204:
1200:
1194:
1190:
1186:
1182:
1178:
1174:
1170:
1167:
1163:
1156:
1154:
1150:
1146:
1142:
1138:
1132:
1128:
1125:
1119:
1117:
1113:
1109:
1105:
1099:
1095:
1092:
1090:RefSeq (mRNA)
1088:
1081:
1080:
1075:
1071:
1068:
1062:
1061:
1056:
1052:
1049:
1047:
1043:
1036:
1035:
1030:
1026:
1023:
1017:
1016:
1011:
1007:
1004:
1002:
998:
991:
990:
985:
981:
978:
972:
971:
966:
962:
959:
957:
953:
950:
947:
945:
942:
938:
935:
931:
927:
920:
916:
911:
905:
902:
900:
897:
895:
892:
890:
887:
885:
882:
880:
877:
875:
872:
870:
867:
865:
862:
860:
857:
855:
852:
850:
847:
845:
842:
840:
837:
835:
832:
830:
827:
825:
822:
820:
817:
815:
812:
810:
809:viral process
807:
805:
802:
800:
797:
795:
792:
790:
787:
786:
784:
781:
780:
774:
771:
769:
766:
764:
761:
759:
756:
754:
751:
749:
746:
744:
741:
739:
736:
734:
731:
729:
726:
724:
721:
719:
716:
714:
711:
709:
706:
704:
701:
699:
696:
694:
691:
690:
688:
685:
684:
678:
675:
673:
670:
668:
665:
663:
660:
658:
655:
653:
650:
648:
645:
643:
640:
638:
635:
633:
630:
628:
625:
623:
620:
619:
617:
614:
613:
610:
609:Gene ontology
606:
602:
590:
585:
581:
574:
569:
566:
564:
560:
552:
547:
536:
532:
528:
524:
520:
516:
512:
508:
504:
500:
499:
496:
492:
487:
484:
474:
470:
466:
462:
458:
454:
450:
446:
442:
438:
437:
434:
430:
425:
422:
421:
418:
416:
412:
410:
409:
405:
404:
401:
399:
395:
391:
387:
383:
375:
370:
366:
362:
357:
347:
343:
336:
329:
323:
316:
308:
304:
300:
295:
291:
286:
282:
274:
269:
265:
261:
256:
246:
242:
235:
228:
222:
215:
211:
205:
201:
197:
192:
188:
183:
179:
175:
171:
167:
163:
159:
155:
151:
147:
143:
139:
131:
126:
119:
114:
109:
98:
96:
92:
88:
84:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
2972:Gangliosides
2880:
2828:Nucleoporins
2769:Autoantigens
2724:
2642:
2639:J. Cell Biol
2638:
2607:
2603:
2572:
2568:
2529:
2525:
2496:
2492:
2457:
2454:J. Cell Biol
2453:
2414:
2411:J. Cell Biol
2410:
2371:
2367:
2331:(1): 120–7.
2328:
2324:
2285:
2281:
2232:
2228:
2179:
2175:
2136:
2132:
2093:
2090:J. Cell Biol
2089:
2052:
2048:
2017:(2): 154–8.
2014:
2010:
1974:
1970:
1925:
1921:
1888:
1884:
1846:
1842:
1832:
1797:
1794:J. Cell Biol
1793:
1783:
1748:
1744:
1734:
1689:
1685:
1675:
1630:
1626:
1616:
1581:
1577:
1567:
1553:
1526:
1522:
1512:
1503:
1494:
1485:
1476:
1385:
1382:Interactions
1376:
1363:
1355:
1354:
1280:NP_001391070
1276:NP_001391069
1272:NP_001391068
1268:NP_001391067
1264:NP_001391066
1260:NP_001391065
1256:NP_001391064
1252:NP_001391063
1249:
1238:NP_001274096
1234:NP_001274095
1230:NP_001274094
1226:NP_001274093
1211:NP_001352058
1207:NP_001352057
1203:NP_001352056
1199:NP_001352055
1196:
1189:NP_001352054
1149:NM_001287167
1145:NM_001287166
1141:NM_001287165
1137:NM_001287164
1134:
1101:
1077:
1058:
1032:
1013:
987:
968:
948:
943:
763:nuclear body
718:nuclear pore
667:mRNA binding
533:spermatocyte
443:right testis
413:
406:
372:101,859,383
359:101,768,605
133:External IDs
72:
2957:Cardiolipin
2707:PDB gallery
844:proteolysis
753:nucleoplasm
743:kinetochore
642:RNA binding
439:left testis
111:Identifiers
3002:Categories
2962:Centromere
2049:Nat. Genet
2011:Nat. Genet
1471:, May 2017
1450:, May 2017
1426:References
463:left ovary
417:(ortholog)
271:3,797,792
258:3,671,083
154:HomoloGene
2604:Mol. Cell
1242:NP_075355
1185:NP_624358
1181:NP_624357
1177:NP_057404
1173:NP_005378
1153:NM_022979
1116:NM_139132
1112:NM_139131
1108:NM_016320
1104:NM_005387
934:Orthologs
773:host cell
509:spermatid
162:GeneCards
2982:Thrombin
2669:11238447
2626:11106761
2591:10875935
2556:10668806
2513:10556215
2484:10209021
2441:10087256
2325:J. Virol
2077:21252465
2001:19024872
1958:25039911
1950:17442773
1913:20926084
1905:15359631
1865:10875935
1824:10209021
1775:12589057
1467:–
1446:–
1388:interact
1373:Function
1328:Wikidata
913:Sources:
713:membrane
2660:2198816
2547:1369901
2475:2133102
2432:2150585
2398:9858599
2355:9847314
2312:9348540
2269:9144189
2237:Bibcode
2216:9114010
2184:Bibcode
2163:8943370
2120:8707840
2111:2120945
2069:8563754
2039:6400265
2031:8563753
1993:7736573
1930:Bibcode
1815:2133102
1726:9144189
1694:Bibcode
1667:9275187
1635:Bibcode
1608:9858599
1545:9166830
1469:Ensembl
1448:Ensembl
1360:protein
1046:UniProt
1001:Ensembl
940:Species
919:QuickGO
738:nucleus
693:cytosol
392:pattern
250:11p15.4
118:Aliases
2926:NUP214
2921:NUP205
2916:NUP210
2911:NUP188
2906:NUP160
2901:NUP155
2896:NUP153
2891:NUP133
2886:NUP107
2667:
2657:
2624:
2589:
2554:
2544:
2511:
2482:
2472:
2439:
2429:
2396:
2386:
2353:
2346:103815
2343:
2310:
2300:
2267:
2257:
2214:
2204:
2161:
2154:231718
2151:
2118:
2108:
2075:
2067:
2037:
2029:
1999:
1991:
1956:
1948:
1911:
1903:
1863:
1822:
1812:
1773:
1766:149995
1763:
1724:
1714:
1665:
1655:
1606:
1596:
1543:
1415:, and
1390:with:
1314:search
1312:PubMed
1079:Q6PFD9
1060:P52948
989:269966
956:Entrez
563:BioGPS
505:zygote
150:109404
142:601021
2947:Actin
2935:Other
2881:NUP98
2876:NUP93
2871:NUP88
2866:NUP85
2861:NUP62
2856:NUP54
2851:NUP50
2846:NUP43
2841:NUP37
2836:NUP35
2493:Blood
2389:83933
2303:25664
2260:24630
2207:20743
2073:S2CID
2035:S2CID
1997:S2CID
1954:S2CID
1909:S2CID
1717:24630
1658:23253
1599:83933
1523:Blood
1419:TNPO2
1407:NUP88
1401:KPNB1
1364:NUP98
1358:is a
949:Mouse
944:Human
915:Amigo
415:Mouse
408:Human
355:Start
290:Mouse
254:Start
187:Human
166:NUP98
158:35472
125:NUP98
22:NUP98
2725:1ko6
2665:PMID
2622:PMID
2587:PMID
2552:PMID
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