192:. Her participation in this research aided in better understanding of protein folding and visualizing of the 3-D structure of proteins by using computational techniques with X-ray crystallography. Additionally, Ahn worked as an undergraduate research assistant in David Teller's lab, which investigated
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Ahn's first postdoctoral job was studying hormone receptor binding at the
University of Washington with Christoph de Haen. Ahn then moved to Edwin Kreb's lab, where she began her career in signal transduction. In this lab, Ahn was "one of the first to describe MAP kinases and MAP kinase kinases." She
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In Ahn's lab, she uses hydrogen-exchange mass spectrometry (HX-MS) to discover and better understand protein motions on the inside of kinases, where energy fluctuations occur. Ahn's goal is to understand how the different protein dynamics are able to regulate catalytic activity in specific enzymes,
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Wnt5A is responsible for controlling embryonic body axis formation and can be found at high levels in melanomas, resulting in cell invasion. Ahn and her lab discovered the "Wnt5a receptor-actin-myosin-polarity (WRAMP) structure," which aids in directional cell movements by triggering membrane
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The lab's goal is to investigate new mechanisms that are responsible for regulation and cell signaling. In order to do this, Ahn uses mass spectrometry for protein profiling in combination with biochemical and cellular approaches to better understand a cell's response to signaling
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Old, William M.; Shabb, John B.; Houel, Stephane; Wang, Hong; Couts, Kasey L.; Yen, Chia-yu; Litman, Elizabeth S.; Croy, Carrie H.; Meyer-Arendt, Karen; Miranda, Jose G.; Brown, Robert A.; Witze, Eric S.; Schweppe, Rebecca E.; Resing, Katheryn A.; Ahn, Natalie G. (2009).
155:. Ahn's work uses the tools of "classical chemistry" to work on understanding the genetic code and how genetics affects life processes. She has been a professor at the University of Colorado at Boulder since 2003, where she is a distinguished professor. She was a
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in a single cell type. In 2012, she was named
College Professor of Distinction at the University of Colorado. In 2014, she became part of the Subcellular Pan-Omics for Advanced Rapid Threat Assessment (SPARTA) team which is a biochemical project supported by the
313:(ASBMB) in the summer of 2015. She was previously a member of the council. She began attending the ASBMB annual meeting while still a PhD student at the University of California, Berkeley and gave her first public research talk at one of these meetings.
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In Ahn's lab, she uses multi dimensional liquid chromatography-MS/MS to identify over 8,000 proteins in each sequence of MS. Ahn's goal is to be more accurate and sensitive in these 2-D-LC-MS/MS techniques in assign
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to discover and count phosphopeptides. Ahn has identified numerous different proteins with this method and with this information studied how cell mechanisms used in cancer therapy were affected by protein-protein
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Ahn is currently working at the
University of Colorado and is conducting research on cell signaling, information and proteomics, and molecular biophysics. Specific topics of her research include:
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most notably protein kinase. Ahn conducts research which focuses on ERK2 MAP kinases, that provide an ideal model due to their clear link between activity and protein dynamics.
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protein contains a missense mutation (V600E mutation), which is responsible for cell transformation, invasion, and metastasis. In order to profile phosphoproteins, Ahn uses
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Ahn studies the development of cancer by examining "signaling pathways that are activated in melanoma and influence cancer progression and cell behavior."
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In addition, Ahn investigates the internal motions of protein kinases, specifically studying their coupling protein dynamics and catalytic function.
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to fund young scientists' work in 1993. She was one of eight project collaborators who won a grant from the
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147:. Her research is focused on understanding the mechanisms of cell signaling, with a speciality in
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Ahn, N. G. (1993). "The MAP kinase cascade. Discovery of a new signal transduction pathway".
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350:"Functional Proteomics Identifies Targets of Phosphorylation by B-Raf Signaling in Melanoma"
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763:"CU Awarded DARPA Cooperative Agreement to Assess Mechanisms of Drugs and Chemical Agents"
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585:"Molecular Anatomy: X-Ray Crystallography Helps Solve the Mystery of Protein Structure"
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392:"New Method For Detection Of Phosphoproteins Reveals Regulator Of Melanoma Invasion"
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started working at the
University of Colorado Boulder in 1992. Ahn was part of the
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retraction. Ahn was able to determine WRAMP structure using organelle proteomics.
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Friedman, Roberta (January 2004). "Finding the Trees in the
Proteomic Forest".
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491:"National Academy of Sciences Members and Foreign Associates Elected"
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investigator between 1994 and 2014. In 2018, she was elected to the
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in 1979. Ahn conducted research in Lyle Jensen's lab, focusing on
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University of
Washington College of Arts and Sciences alumni
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Members of the United States
National Academy of Sciences
561:"Feature: Meet Natalie Ahn, ASBMB's incoming president"
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American
Society for Biochemistry and Molecular Biology
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University of
Colorado Health Sciences Center, Denver
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Fellows of the
American Academy of Arts and Sciences
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839:UC Berkeley College of Letters and Science alumni
207:. Here, Ahn worked with Judith Klinman, studying
674:"Following the Pathways to Metastatic Melanoma"
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493:. National Academy of Sciences. 1 May 2018
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230:Defense Advanced Research Projects Agency
646:. University of Colorado. Archived from
277:negative precursor ion mass spectrometry
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874:21st-century American women scientists
849:University of Colorado Boulder faculty
864:21st-century American women academics
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244:Proteomics and Signal Transduction:
176:Past education, research, and awards
834:Howard Hughes Medical Investigators
804:Howard Hughes Medical Institute bio
678:Colorado Arts and Sciences Magazine
324:Molecular and cellular biochemistry
769:. 12 February 2014. Archived from
205:University of California, Berkeley
40:University of California, Berkeley
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879:21st-century American biochemists
309:Ahn was elected president of the
186:University of Washington, Seattle
145:University of Colorado at Boulder
74:University of Colorado at Boulder
33:University of Washington, Seattle
739:. September 2009. Archived from
680:. University of Colorado Boulder
398:(Press release). April 17, 2009.
869:21st-century American academics
470:Howard Hughes Medical Institute
271:In half of melanoma cells, the
157:Howard Hughes Medical Institute
88:Howard Hughes Medical Institute
781:– via HighBeam Research.
444:University of Colorado Boulder
1:
733:"CU People – September 2009"
366:10.1016/j.molcel.2009.03.007
161:National Academy of Sciences
109:Other academic advisors
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829:American women biochemists
199:In 1985, she received her
163:and named a fellow of the
613:Harding, Stephen (1999).
413:Genomics & Proteomics
294:Protein Kinase Dynamics:
285:Proteomics Technologies:
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707:Searle Scholars Program
672:Talbott, Clint (2013).
615:"Protein Hydrodynamics"
513:"Newly Elected Fellows"
217:Searle Scholars Program
644:BioFrontiers Institute
184:in chemistry from the
466:"Natalie G. Ahn, PhD"
194:protein hydrodynamics
190:X-ray crystallography
773:on 11 September 2016
221:W.M. Keck Foundation
203:in chemistry at the
737:Coloradan Magazine
589:www.washington.edu
517:members.amacad.org
326:. 127–128: 201–9.
305:Community service
268:B-Raf signaling:
259:Wnt5A signaling:
182:bachelor's degree
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117:Christoph de Haën
103:Judith P. Klinman
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50:Scientific career
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797:Official website
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743:on 30 March 2010
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703:"Natalie G. Ahn"
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91:(1994–2014 )
70:Institutions
64:Biochemistry
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36:(B.S., 1979)
809:Official CV
522:January 13,
419:(1): 38–40.
113:Edwin Krebs
818:Categories
777:15 January
747:15 January
717:15 January
684:15 January
654:15 January
628:: 271–305.
599:2016-11-08
570:2016-11-08
475:15 January
335:References
280:signaling.
209:enzymology
289:proteins.
248:pathways.
232:(DARPA).
171:Biography
137:chemistry
133:professor
60:Chemistry
384:19362540
225:proteins
84:(2003– )
77:(1992– )
375:2735263
153:cancers
143:at the
497:12 May
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56:Fields
618:(PDF)
273:B-Raf
131:is a
779:2016
749:2016
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686:2016
656:2016
524:2019
499:2018
477:2016
452:2018
380:PMID
328:PMID
151:and
139:and
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370:PMC
362:doi
201:PhD
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