167:
and Necls are much related in function and protein structure and have been found to interact in a variety of way, which it is why it makes good sense to define them as families. However, if you consider the sequence of the genes encoding the proteins an alternative way of naming the proteins also make sense as pointed out by Thomas
Biederer. Alternative names for nectins and Necls are listed below.
233:
Nectin-1 and nectin-3 have been shown to be involved in cellular adhesion in some neuronal synapses. Unlike many other cellular adhesion molecules they do not distribute evenly on axonal and dendritic side of the synapse. Instead, Nectin-1 is primarily found on the axonal side and nectin-3 primarily
166:
Since the research of nectins has been approached from several angles there is still some controversy about the names of these proteins and the genes encoding them. The idea of grouping these proteins into nectins and Necls originates from Dr. Youhsimi Takais early studies of the proteins. Nectins
150:
All nectins and Necls can form homo-cis dimers, meaning a dimer of two alike molecules on the same cell membrane. Following the homo-dimer formation they can trans-interact in an either heterophilic or homophilic manner. The network of the nectin and Necl trans-interactions has been characterized.
151:
Recent structural reports reveal the physical and chemical determinants of homophilic interactions mediated by N-terminal IgV domains. In general, heterophilic interactions among nectins have higher affinity than their respective homophilic interactions.
237:
Recently, it has been found that nectin-4 can be found in the serum of patients with lung cancer. This has led to speculations that this protein might be involved in some developing cancers and might even have a pharmaceutical potential.
444:
241:
Also, it has been well known for some time now, that necl-2 is down regulated in a variety of cancers. This is why necl-2 is also known as Tumor suppressor in lung cancer 1 (TSLC1).
234:
on the dendritic side. Nectin-1 serves as the entry receptor for Herpes
Simplex Viruses 1 and 2, binding to the viral envelope glycoprotein gD, and for Pseudorabies Virus.
488:
213:), SynCAM1 (Synaptic cell adhesion molecule 1), IGSF4 (Immunoglobulin super family member 4), sgIGSF (Spermatogenic immunoglobulin superfamily), RA175
256:
was approved by the FDA in 2019; it is a Nectin-4-directed antibody drug conjugate that has shown clinical activity in metastatic urothelial cancer.
637:
202:(Cell adhesion molecule 3), TSLL1 (TSLC1-like 1), SynCAM3 (Synaptic cell adhesion molecule 3), IGSF4B (Immunoglobulin super family member 4B)
481:
343:
Fuchs, Anja; Colonna, M (October 2006). "The role of NK cell recognition of nectin and nectin-like proteins in tumor immunosurveillance".
107:. These four family members have also been found in most other well studied mammals. Also, five Necls have been identified, these are:
1006:
1027:
474:
536:
526:
954:
57:
139:, a single transmembrane helix and an intracellular domain. For all nectins the intracellular domain can bind a
986:
276:
181:(Poliovirus receptor-related 2), HveB (herpesvirus entry mediator B), CD112 (Cluster of Differentiation 112)
174:(Poliovirus receptor-related 1), HveC (herpesvirus entry mediator C), CD111 (Cluster of Differentiation 111)
716:
509:
501:
693:
136:
665:
651:
530:
210:
40:
71:
Nectins are ubiquitously expressed and have adhesive roles in a wide range of tissues such as the
253:
61:
401:
360:
322:
72:
65:
466:
445:"FDA grants accelerated approval to enfortumab vedotin-ejfv for metastatic urothelial cancer"
831:
497:
391:
352:
312:
302:
140:
120:
116:
80:
192:
135:
All nectins and all Necls share the same overall structure defined by three extra cellular
317:
291:"Nectins and nectin-like molecules: roles in cell adhesion, migration, and polarization"
290:
307:
431:"NECTIN1 nectin cell adhesion molecule 1 [Homo sapiens (human)] - Gene - NCBI"
1021:
813:
356:
784:
780:
776:
772:
565:
272:
857:
790:
750:
740:
219:
necl-4 : TSLL2 (TSLC1-like 2), SynCAM4 (Synaptic cell adhesion molecule 1)
963:
934:
929:
924:
847:
768:
45:
760:
560:
76:
405:
364:
326:
418:
969:
916:
725:
629:
518:
430:
249:
155:
104:
100:
96:
92:
188:(Poliovirus receptor-related 3), CD113 (Cluster of Differentiation 113)
396:
379:
826:
697:
550:
540:
1001:
978:
974:
902:
892:
887:
882:
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821:
701:
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669:
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570:
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223:
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144:
124:
112:
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996:
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555:
470:
289:
Takai Y, Irie K, Shimizu K, Sakisaka T, Ikeda W (Aug 2003).
91:
So far four nectins have been identified in humans, namely
216:
necl-3 : SynCAM2 (Synaptic cell adhesion molecule 2)
380:"Nectin and nectin-like molecules: biology and pathology"
209:(Cell adhesion molecule 1), TSLC1 (Tumor suppressor in
195:(Poliovirus receptor-related 4), LNIR; PRR4; EDSS1
947:
915:
840:
812:
759:
733:
724:
715:
628:
517:
508:
39:
31:
26:
21:
56:and Nectin-like molecules (Necl) are families of
222:necl-5 : Tage4, PVR (Poliovirus receptor),
482:
8:
338:
336:
730:
721:
514:
489:
475:
467:
395:
316:
306:
275:at the U.S. National Library of Medicine
265:
18:
16:Family of cellular adhesion molecules
7:
419:Nectin 4 – cell adhesion molecule 4
154:Nectins and Necls can also recruit
308:10.1111/j.1349-7006.2003.tb01499.x
14:
143:named afadin (the product of the
378:Miyoshi J, Takai Y (Sep 2007).
357:10.1016/j.semcancer.2006.07.002
384:American Journal of Nephrology
1:
58:cellular adhesion molecules
1044:
955:Lymphocyte homing receptor
345:Seminars in Cancer Biology
987:Carcinoembryonic antigen
841:Unconventional/ungrouped
277:Medical Subject Headings
162:Nomenclature controversy
83:of the neuronal tissue.
1028:Cell adhesion molecules
502:cell adhesion molecules
254:Enfortumab vedotin-ejfv
137:immunoglobulin domains
694:Glycoprotein IIb/IIIa
22:Nectin-like receptors
666:Macrophage-1 antigen
652:Integrin alphaXbeta2
158:to enhance binding.
531:Myelin protein zero
510:Calcium-independent
451:. 20 December 2019
229:Clinical relevance
1015:
1014:
943:
942:
911:
910:
717:Calcium-dependent
711:
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498:Membrane proteins
397:10.1159/000108103
73:adherens junction
66:cellular adhesion
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50:
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245:As a drug target
191:nectin-4 :
184:nectin-3 :
177:nectin-2 :
170:nectin-1 :
141:scaffold protein
81:chemical synapse
19:
1043:
1042:
1038:
1037:
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1018:
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1016:
1011:
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5:
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728:
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436:
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411:
390:(6): 590–604.
370:
351:(5): 359–366.
332:
295:Cancer Science
281:
264:
263:
261:
258:
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205:necl-2 :
198:necl-1 :
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88:
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43:
37:
36:
33:
29:
28:
24:
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15:
13:
10:
9:
6:
4:
3:
2:
1040:
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828:
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823:
820:
819:
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815:
814:Protocadherin
811:
804:
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792:
789:
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766:
764:
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747:
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738:
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723:
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703:
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664:
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619:
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328:
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314:
309:
304:
301:(8): 655–67.
300:
296:
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285:
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274:
269:
266:
259:
257:
255:
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244:
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211:lung cancer 1
208:
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64:-independent
63:
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38:
34:
30:
25:
20:
968:
587:
453:. Retrieved
448:
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134:
90:
70:
60:involved in
53:
52:
791:Desmocollin
27:Identifiers
964:L-selectin
935:P-selectin
930:L-selectin
925:E-selectin
848:T-cadherin
769:Desmoglein
761:Desmosomal
260:References
41:Membranome
917:Selectins
734:Classical
726:Cadherins
630:Integrins
561:L1 family
156:cadherins
131:Structure
87:Diversity
77:epithelia
1022:Category
970:integrin
519:IgSF CAM
406:17823505
365:16904340
327:12901789
318:11160195
252: :
250:Nectin-4
105:nectin-4
101:nectin-3
97:nectin-2
93:nectin-1
455:May 30,
449:fda.gov
273:nectins
147:gene).
79:or the
54:Nectins
832:PCDH19
827:PCDH15
698:ITGA2B
588:Nectin
566:L1-CAM
556:PE-CAM
551:VCAM-1
404:
363:
325:
315:
279:(MeSH)
125:Necl-5
121:Necl-4
117:Necl-3
113:Necl-2
109:Necl-1
35:Nectin
32:Symbol
1007:EpCAM
1002:CD146
979:LFA-1
975:VLA-4
948:Other
903:CDH10
893:CDH17
888:CDH16
883:CDH15
878:CDH12
873:CDH11
822:PCDH1
702:ITGB3
684:CD49d
680:VLA-4
670:CD11b
656:CD11c
642:CD11a
638:LFA-1
618:CD155
613:CADM3
608:CADM1
603:PVRL3
598:PVRL2
593:PVRL1
576:NFASC
571:NRCAM
527:N-CAM
224:CD155
207:CADM1
200:CADM3
193:PVRL4
186:PVRL3
179:PVRL2
172:PVRL1
145:MLLT4
997:CD44
992:CD24
959:CD44
898:CDH9
868:CDH8
863:CDH6
858:CDH5
853:CDH4
803:DSC3
799:DSC2
795:DSC1
785:DSG4
781:DSG3
777:DSG2
773:DSG1
751:CDH3
746:CDH2
741:CDH1
688:CD29
674:CD18
660:CD18
646:CD18
581:CHL1
537:ICAM
457:2021
402:PMID
361:PMID
323:PMID
123:and
103:and
392:doi
353:doi
313:PMC
303:doi
75:of
46:220
1024::
977:,
957::
801:,
797:,
783:,
779:,
775:,
543:,
500::
447:.
400:.
388:27
386:.
382:.
359:.
349:16
347:.
335:^
321:.
311:.
299:94
297:.
293:.
127:.
119:,
115:,
111:,
99:,
95:,
68:.
62:Ca
981:)
973:(
805:)
793:(
787:)
771:(
704:)
700:+
696:(
690:)
686:+
682:(
676:)
672:+
668:(
662:)
658:+
654:(
648:)
644:+
640:(
547:)
545:5
541:1
539:(
533:)
529:(
490:e
483:t
476:v
459:.
433:.
408:.
394::
367:.
355::
329:.
305::
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