556:
533:
31:
6072:
1580:
1540:
1497:
867:
Neratinib is found to strongly reduce the amount of HER2 released by extracellular vescicles and to enhance the capacity of clathrin mediated endocytosis. However, despite HER2 mediated signaling downregulation, Neratinib exerts only a modest effect on HER2 trafficking at IC50 of 6nM in SKBR3 cells.
854:
values of 0.8 μM and 1.4 μM, respectively. In BT474 cells, neratinib reduces HER2 autophosphorylation, and inhibited cyclin D1 expression while reduced proliferation has been observed A431 cells when treated with neratinib at concentrations of 3 or 5 nM. In xenograft models with 3T3/neu tumors oral
907:-overexpressed/amplified breast cancer, (after adjuvant trastuzumab-based therapy). Approval was based on the ExteNET trial (NCT00878709), a multicenter, randomized, double-blind, placebo-controlled trial of neratinib following adjuvant trastuzumab treatment.
724:
The most common side effect is diarrhea, which affects nearly all patients. Other common side effects include nausea (feeling sick), vomiting, tiredness, belly pain, rash, decreased appetite, stomatitis (sore, inflamed mouth), and muscle spasms.
737:
for the extended adjuvant treatment of adults with early stage hormone receptor positive HER2-overexpressed/amplified breast cancer and who are less than one year from the completion of prior adjuvant trastuzumab based therapy.
670:
InChI=1S/C30H29ClN6O3/c1-4-39-28-16-25-23(15-26(28)36-29(38)9-7-13-37(2)3)30(20(17-32)18-34-25)35-21-10-11-27(24(31)14-21)40-19-22-8-5-6-12-33-22/h5-12,14-16,18H,4,13,19H2,1-3H3,(H,34,35)(H,36,38)/b9-7+
753:
Women who are pregnant should not take it, and women should not become pregnant while taking it, and women who are breast-feeding should not use it, as it can cause harm to the fetus and to the baby.
761:
Neratinib can cause life-threatening diarrhea in some people and mild to moderate diarrhea in almost everyone; people who take it are also at risk for complications of diarrhea like dehydration and
1707:
254:
3138:
1517:
776:
In addition to the above, more than 10% of people taking it have nausea, abdominal pain, vomiting, sores on their lips, stomach upset, decreased appetite, rashes, and muscle spasms.
803:
increase the activity of neratinib and can make adverse effects worse, and drugs that induce CYP3A4 make neratinib less active and can reduce its efficacy. Neratinib also inhibits
146:
209:
686:
628:
769:
and many patients have some level of it; symptoms of liver damage include fatigue, nausea, vomiting, right upper quadrant pain or tenderness, fever, rash, and high levels of
745:, for the treatment of adults with advanced or metastatic HER2-positive breast cancer who have received two or more prior anti-HER2 based regimens in the metastatic setting.
1423:
1700:
5053:
3131:
6013:
61:
6132:
642:
5669:
4817:
1693:
4434:
3124:
4492:
1474:
5354:
5044:
828:
1127:"The major lung cancer-derived mutants of ERBB2 are oncogenic and are associated with sensitivity to the irreversible EGFR/ERBB2 inhibitor HKI-272"
112:
4649:
2699:
2342:
3634:
3317:
1066:
Text was copied from this source which is copyright
European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
6032:
5982:
5953:
5900:
4387:
4254:
5711:
5707:
5703:
5699:
3252:
3236:
1835:
3980:
3899:
3766:
3683:
935:
5695:
2813:
5384:
4503:
4063:
3674:
707:
662:
142:
3332:
3276:
3267:
2233:
1759:
832:
1679:
for "Study
Evaluating The Effects Of Neratinib After Adjuvant Trastuzumab In Women With Early Stage Breast Cancer (ExteNET)" at
1009:
5906:
318:
239:
93:
5993:
5969:
5109:
4665:
4528:
1374:"Imaging of Endocytic Trafficking and Extracellular Vesicles Released Under Neratinib Treatment in ERBB2 Breast Cancer Cells"
5959:
6062:
6122:
6003:
4399:
4281:
4271:
2579:
1563:
1523:
1480:
1447:
839:
with a cysteine side chain in those proteins. Unlike related noncovalent inhibitors, neratinib is effective against the
836:
444:
6092:
5349:
1736:
1557:
512:
5374:
2760:
129:
5988:
3814:
2885:
2734:
2483:
1985:
5369:
5896:
2210:
2076:
1789:
1441:
1051:
715:
107:
6097:
4080:
3996:
3915:
3782:
3699:
2220:
1746:
1325:"New mouse xenograft model modulated by tumor-associated fibroblasts for human multi-drug resistance in cancer"
3514:
393:
1662:
5680:
3427:
3302:
1716:
789:
183:
5359:
551:
6117:
5964:
5580:
5484:
5344:
5104:
4523:
3509:
3147:
2588:
2071:
1800:
785:
718:
501:
6107:
6102:
6038:
4235:
3879:
3519:
3158:
2146:
2086:
2056:
1959:
1795:
1685:
762:
734:
384:
1650:
5978:
5364:
4296:
4245:
2001:
1896:
1733:
1228:
855:
administration of neratinib at 10, 20, 40 or 80 mg/kg was able to inhibit tumor growth while in
202:
5114:
3189:
528:
6127:
5119:
4533:
4230:
3422:
2854:
2121:
2111:
1931:
1638:
1518:"FDA approves neratinib for extended adjuvant treatment of early stage HER2-positive breast cancer"
339:
190:
4155:
5737:
5650:
5595:
5549:
5494:
5229:
5169:
4797:
4170:
4100:
3659:
3257:
3199:
3150:
2509:
2151:
2141:
2126:
2046:
1680:
1276:"Neratinib shows efficacy in the treatment of HER2 amplified carcinosarcoma in vitro and in vivo"
1197:
900:
893:
157:
5732:
5610:
5509:
5295:
5184:
4984:
4944:
4692:
4611:
4473:
4414:
4376:
4321:
4316:
4306:
4180:
4175:
4145:
4120:
4115:
4105:
3991:
3910:
3849:
3777:
3756:
3741:
3694:
3347:
1372:
Santamaria S, Gagliani MC, Bellese G, Marconi S, Lechiara A, Dameri M, et al. (July 2021).
5832:
5690:
5625:
5605:
5524:
5504:
5219:
5199:
5179:
4822:
4150:
3874:
3407:
3204:
6112:
5655:
5645:
5600:
5554:
5544:
5499:
5424:
5323:
5290:
5270:
5234:
5224:
5174:
5134:
4606:
4586:
4553:
4336:
4185:
2186:
1405:
1354:
1305:
1256:
1189:
1148:
1107:
291:
278:
266:
43:
5615:
5514:
5409:
5313:
5265:
5258:
5244:
5189:
5159:
4639:
4629:
4581:
4563:
4326:
4165:
4110:
1217:"The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP"
433:
5842:
4974:
2026:
1868:
1863:
1395:
1385:
1344:
1336:
1295:
1287:
1246:
1236:
1179:
1138:
1125:
Minami Y, Shimamura T, Shah K, LaFramboise T, Glatt KA, Liniker E, et al. (July 2007).
1097:
1089:
1046:
568:
348:
4366:
453:
6076:
5454:
1215:
Yun CH, Mengwasser KE, Toms AV, Woo MS, Greulich H, Wong KK, et al. (February 2008).
1626:
1274:
Schwab CL, English DP, Black J, Bellone S, Lopez S, Cocco E, et al. (October 2015).
555:
532:
71:
1232:
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2116:
2081:
1901:
1881:
1584:
1544:
1501:
1093:
940:
544:
85:
3116:
899:
It was approved for medical use in the United States in July 2017, for the extended
784:
People taking neratinib should not also take gastric acid reducing agents including
373:
6048:
6018:
5757:
5747:
5640:
5539:
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5214:
5149:
5064:
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2522:
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2196:
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2011:
1981:
1906:
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1201:
766:
742:
222:
217:
1675:
30:
963:
6008:
5974:
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5019:
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4409:
4361:
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4341:
4225:
4220:
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3504:
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3462:
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3447:
3437:
3397:
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3055:
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3010:
3005:
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2916:
2818:
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2715:
2710:
2705:
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2534:
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1976:
1941:
1921:
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1840:
1828:
1823:
1785:
1769:
1597:
1424:"Puma Acquires Global Rights to Pfizer's Phase III Breast Cancer Drug Neratinib"
1291:
770:
79:
1221:
Proceedings of the
National Academy of Sciences of the United States of America
964:"Nerlynx 40 mg Film-coated Tablets - Summary of Product Characteristics (SmPC)"
330:)-N-phenyl]amino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide
5827:
5792:
5787:
5777:
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5685:
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5239:
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4707:
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2171:
2106:
2066:
2061:
2041:
2036:
2016:
2006:
1996:
1911:
1891:
1873:
1781:
1390:
604:
424:
197:
910:
Neratinib was approved for medical use in the
European Union in August 2018.
5852:
5822:
5817:
5812:
5807:
5802:
5782:
5772:
5762:
5752:
5444:
5404:
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820:
65:
1409:
1358:
1309:
1260:
1193:
1152:
1143:
1126:
1111:
892:
continued development up to Phase III in breast cancer, and licensed it to
850:
of 59 nM against HER2 and shows weak inhibition against KDR and Scr with IC
1475:"FDA approves new treatment to reduce the risk of breast cancer returning"
859:
models doses of 5 and 60 mg/kg significantly inhibited tumor growth.
22:
6023:
5742:
5399:
4999:
4989:
4969:
4904:
4873:
4842:
4806:
4712:
4702:
4049:
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2413:
2352:
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2268:
2238:
1991:
1855:
1851:
1776:
1340:
824:
793:
404:
124:
413:
5998:
5419:
4884:
4286:
3247:
1949:
856:
808:
359:
1323:
Ma Y, Lin Z, Fallon JK, Zhao Q, Liu D, Wang Y, Liu F (November 2015).
5911:
5575:
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4458:
4454:
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1167:
481:
473:
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5931:
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5923:
5919:
5915:
5630:
5529:
5204:
5144:
4958:
4681:
4677:
4673:
4669:
4160:
4024:
3943:
3939:
3838:
3834:
3830:
3826:
3735:
3731:
3582:
2829:
2555:
2389:
2338:
1818:
885:
840:
627:
618:
1583:
This article incorporates text from this source, which is in the
1543:
This article incorporates text from this source, which is in the
1500:
This article incorporates text from this source, which is in the
1078:"Advances in the management of HER2-positive early breast cancer"
5414:
4020:
4016:
4012:
4008:
4004:
4000:
3935:
3931:
3927:
3923:
3919:
3822:
3818:
3810:
3806:
3802:
3798:
3794:
3790:
3786:
3727:
3723:
3719:
3715:
3711:
3707:
3703:
3655:
3651:
3647:
3613:
3578:
3559:
2944:
2730:
2228:
1954:
1936:
1926:
1886:
1754:
904:
741:
In the United States, it is also indicated, in combination with
650:
CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)C=CCN(C)C
464:
297:
272:
102:
3120:
1689:
285:
136:
119:
111:
517:
248:
168:
1076:
Baselga J, Coleman RE, Cortés J, Janni W (November 2017).
733:
In the
European Union and the United States, neratinib is
261:
1166:
Singh J, Petter RC, Baillie TA, Whitty A (April 2011).
876:
Neratinib is a 4-anilino-3-cyano quinoline derivative.
693:
6014:
Pituitary adenylate cyclase-activating peptide (PACAP)
918:
In
Bangladesh it is sold under the trade name Hernix.
6060:
1004:
884:
Neratinib was discovered and initially developed by
5881:
5668:
5563:
5332:
5072:
5063:
5043:
4957:
4934:
4903:
4872:
4841:
4805:
4796:
4648:
4491:
4424:
4386:
4253:
4244:
4062:
4039:
3979:
3898:
3765:
3682:
3673:
3612:
3558:
3471:
3275:
3266:
3235:
3157:
2801:
2578:
2219:
2209:
1969:
1850:
1810:
1745:
1732:
1002:
1000:
998:
996:
994:
992:
990:
988:
986:
984:
796:may be used three hours before of after taking it.
616:
603:
567:
562:
543:
511:
491:
463:
443:
423:
403:
392:
383:
358:
338:
309:
238:
233:
208:
196:
182:
156:
92:
78:
60:
52:
42:
37:
5960:Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)
4818:Glial cell line-derived neurotrophic factor (GDNF)
4471:Cleavage products/derivatives with unknown target:
1469:
1467:
5994:Macrophage-stimulating protein (MSP; HLP, HGFLP)
1512:
1510:
372:
3635:Heparin-binding EGF-like growth factor (HB-EGF)
3318:Heparin-binding EGF-like growth factor (HB-EGF)
1378:The Journal of Histochemistry and Cytochemistry
347:
1041:
1039:
1037:
1035:
1033:
1031:
807:and effectively raises the dose of drugs like
141:
6046:Additional growth factor receptor modulators:
3132:
1701:
936:"Summary Basis of Decision (SBD) for Nerlynx"
8:
4400:Insulin-like growth factor-2 (somatomedin A)
4282:Insulin-like growth factor-2 (somatomedin A)
4272:Insulin-like growth factor-1 (somatomedin C)
128:
21:
5069:
4802:
4250:
3679:
3272:
3139:
3125:
3117:
2216:
1742:
1708:
1694:
1686:
554:
531:
432:
29:
1399:
1389:
1348:
1299:
1250:
1240:
1183:
1142:
1101:
721:used for the treatment of breast cancer.
452:
6004:Migration-stimulating factor (MSF; PRG4)
829:human epidermal growth factor receptor 2
765:. Similarly, there is a risk of severe
6067:
3333:Transforming growth factor alpha (TGFα)
1082:Critical Reviews in Oncology/Hematology
927:
667:
647:
527:
412:
323:
84:
5907:Connective tissue growth factor (CTGF)
545:
20:
5970:Hepatoma-derived growth factor (HDGF)
1442:"Nerlynx (neratinib maleate) Tablets"
500:
70:
7:
1645:. U.S. National Library of Medicine.
1633:. U.S. National Library of Medicine.
221:
6133:Receptor tyrosine kinase inhibitors
837:inhibits them by covalently binding
811:that depend on it for elimination.
480:
472:
363:
1168:"The resurgence of covalent drugs"
14:
6070:
5989:Leukemia inhibitory factor (LIF)
1578:
1538:
1495:
1094:10.1016/j.critrevonc.2017.10.001
833:epidermal growth factor receptor
827:, it is a dual inhibitor of the
588:
585:
579:
5157:Negative allosteric modulators:
1558:"Drug Trials Snapshot: Nerlynx"
675:Key:JWNPDZNEKVCWMY-VQHVLOKHSA-N
5475:Gossypetin (3,5,7,8,3',4'-HHF)
4666:Platelet-derived growth factor
1172:Nature Reviews. Drug Discovery
594:
573:
1:
5681:Placental growth factor (PGF)
1485:(Press release). 17 July 2017
710:), sold under the brand name
5965:Glia maturation factor (GMF)
4474:Glypromate (GPE, (1-3)IGF-1)
1669:. National Cancer Institute.
1564:Food and Drug Administration
1524:Food and Drug Administration
1481:Food and Drug Administration
1448:Food and Drug Administration
1292:10.1016/j.ygyno.2015.08.002
1010:"Nerlynx- neratinib tablet"
903:of adults with early stage
843:resistant variant of EGFR.
6149:
5897:Colony-stimulating factors
5889:Additional growth factors:
2211:Tyrosine kinase inhibitors
563:Chemical and physical data
5245:SNA-120 (pegylated K252a)
4417:(against IGF-1 and IGF-2)
4379:(against IGF-1 and IGF-2)
2077:Mirvetuximab soravtansine
1655:National Cancer Institute
1391:10.1369/00221554211026297
1052:European Medicines Agency
716:tyrosine kinase inhibitor
683:
658:
638:
314:
28:
4081:Hepatocyte growth factor
3640:Neuregulins (heregulins)
3571:Neuregulins (heregulins)
3515:Trastuzumab duocarmazine
3228:(against angiopoietin 2)
3222:(against angiopoietin 3)
2221:Receptor tyrosine kinase
1747:Receptor tyrosine kinase
3428:Depatuxizumab mafodotin
1811:Others for solid tumors
1717:Targeted cancer therapy
1643:Drug Information Portal
1631:Drug Information Portal
1242:10.1073/pnas.0709662105
790:H2-receptor antagonists
6051:(neurotrophin mixture)
6039:Wnt signaling proteins
5720:Allosteric modulators:
5440:Norwogonin (5,7,8-THF)
3660:5 (tomoregulin, TMEFF)
3510:Trastuzumab deruxtecan
3148:Growth factor receptor
2072:Loncastuximab tesirine
1801:Trastuzumab deruxtecan
1673:Clinical trial number
1144:10.1038/sj.onc.1210292
786:proton pump inhibitors
719:anti-cancer medication
5979:T-cell growth factors
4236:Telisotuzumab vedotin
3520:Trastuzumab emtansine
2147:Sacituzumab govitecan
2087:Moxetumomab pasudotox
2057:Inotuzumab ozogamicin
1960:Gemtuzumab ozogamicin
1796:Trastuzumab emtansine
1737:monoclonal antibodies
1721:antineoplastic agents
763:electrolyte imbalance
4564:EVT-901 (SAR-127963)
4297:Mecasermin rinfabate
2002:Belantamab mafodotin
1341:10.3892/or.2015.4265
1280:Gynecologic Oncology
203:Antineoplastic agent
6123:2-Pyridyl compounds
2855:Denileukin diftitox
2517:(ALK, ROS1, NTRK),
2122:Polatuzumab vedotin
2112:Oportuzumab monatox
1667:NCI Drug Dictionary
1663:"Neratinib maleate"
1651:"Neratinib maleate"
1639:"Neratinib maleate"
1233:2008PNAS..105.2070Y
1056:. 17 September 2018
846:Neratinib has an IC
835:(EGFR) kinases. It
799:Drugs that inhibit
281:(Prescription only)
257:(Prescription only)
25:
6093:Alkene derivatives
5730:Kinase inhibitors:
5593:Kinase inhibitors:
5492:Kinase inhibitors:
5167:Kinase inhibitors:
4982:Kinase inhibitors:
4942:Kinase inhibitors:
4923:Kinase inhibitors:
4892:Kinase inhibitors:
4861:Kinase inhibitors:
4830:Kinase inhibitors:
4690:Kinase inhibitors:
4304:Kinase inhibitors:
4098:Kinase inhibitors:
3887:Kinase inhibitors:
3880:Aprutumab ixadotin
3527:Kinase inhibitors:
3340:Kinase inhibitors:
3197:Kinase inhibitors:
2541:(ROS1, TRK, ALK),
2047:Enfortumab vedotin
1681:ClinicalTrials.gov
901:adjuvant treatment
894:Puma Biotechnology
6058:
6057:
5664:
5663:
5425:N-Acetylserotonin
5324:ReN-1820 (TrkAd5)
4953:
4952:
4487:
4486:
4432:Binding proteins:
4091:Dihexa (PNB-0408)
4058:
4057:
3669:
3668:
3583:6 (neuroglycan C)
3303:EGF (urogastrone)
3281:
3114:
3113:
2797:
2796:
2205:
2204:
2187:Tisotumab vedotin
1430:. 6 October 2011.
1137:(34): 5023–5027.
944:. 23 October 2014
749:Contraindications
701:
700:
629:Interactive image
513:CompTox Dashboard
301:
289:
276:
264:
252:
172:
139:
122:
105:
16:Chemical compound
6140:
6075:
6074:
6073:
6066:
5870:Decoy receptors:
5843:Alacizumab pegol
5321:Decoy receptors:
5070:
4975:Stem cell factor
4916:Persephin (PSPN)
4854:Neurturin (NRTN)
4803:
4640:LEVI-04 (p75-Fc)
4637:Decoy receptors:
4251:
3680:
3279:
3273:
3141:
3134:
3127:
3118:
2828:peptide against
2401:(AXL, ALK, LTK))
2217:
2027:Dinutuximab beta
1743:
1710:
1703:
1696:
1687:
1670:
1658:
1646:
1634:
1613:
1612:
1610:
1608:
1594:
1588:
1582:
1581:
1577:
1575:
1573:
1554:
1548:
1542:
1541:
1537:
1535:
1533:
1514:
1505:
1499:
1498:
1494:
1492:
1490:
1471:
1462:
1461:
1459:
1457:
1452:. 21 August 2017
1438:
1432:
1431:
1420:
1414:
1413:
1403:
1393:
1369:
1363:
1362:
1352:
1335:(5): 2699–2705.
1329:Oncology Reports
1320:
1314:
1313:
1303:
1271:
1265:
1264:
1254:
1244:
1227:(6): 2070–2075.
1212:
1206:
1205:
1187:
1163:
1157:
1156:
1146:
1122:
1116:
1115:
1105:
1073:
1067:
1065:
1063:
1061:
1043:
1026:
1025:
1023:
1021:
1006:
979:
978:
976:
974:
960:
954:
953:
951:
949:
932:
697:
696:
689:
631:
611:
596:
590:
587:
581:
575:
558:
547:
536:
535:
521:
519:
504:
484:
476:
456:
436:
416:
396:
376:
366:
365:
351:
299:
296:
287:
284:
274:
271:
263:
260:
250:
247:
225:
170:
167:
149:
138:
135:
132:
121:
118:
115:
104:
101:
88:
74:
33:
26:
24:
6148:
6147:
6143:
6142:
6141:
6139:
6138:
6137:
6098:Aromatic amines
6083:
6082:
6081:
6071:
6069:
6061:
6059:
6054:
5999:Midkine (NEGF2)
5877:
5660:
5559:
5328:
5266:ABT-110 (PG110)
5059:
5039:
4949:
4930:
4899:
4868:
4837:
4792:
4644:
4582:ABT-110 (PG110)
4483:
4420:
4382:
4240:
4054:
4035:
3975:
3972:(against FGF23)
3894:
3761:
3665:
3608:
3554:
3467:
3278:
3262:
3231:
3153:
3145:
3115:
3110:
2964:Pi3K inhibitors
2862:mTOR inhibitors
2793:
2574:
2545:(VEGFR, FGFR),
2201:
1965:
1846:
1806:
1728:
1714:
1661:
1657:. 27 July 2017.
1649:
1637:
1625:
1622:
1617:
1616:
1606:
1604:
1596:
1595:
1591:
1579:
1571:
1569:
1556:
1555:
1551:
1539:
1531:
1529:
1516:
1515:
1508:
1496:
1488:
1486:
1473:
1472:
1465:
1455:
1453:
1440:
1439:
1435:
1422:
1421:
1417:
1371:
1370:
1366:
1322:
1321:
1317:
1273:
1272:
1268:
1214:
1213:
1209:
1185:10.1038/nrd3410
1165:
1164:
1160:
1124:
1123:
1119:
1075:
1074:
1070:
1059:
1057:
1045:
1044:
1029:
1019:
1017:
1016:. 6 August 2020
1008:
1007:
982:
972:
970:
962:
961:
957:
947:
945:
934:
933:
929:
924:
916:
882:
874:
865:
853:
849:
817:
782:
759:
757:Adverse effects
751:
731:
692:
690:
687:(what is this?)
684:
679:
676:
671:
666:
665:
654:
651:
646:
645:
634:
609:
599:
593:
584:
578:
539:
515:
507:
487:
459:
439:
419:
399:
379:
362:
354:
334:
331:
322:
321:
305:
229:
185:
178:
159:
152:
48:Nerlynx, Hernix
17:
12:
11:
5:
6146:
6144:
6136:
6135:
6130:
6125:
6120:
6115:
6110:
6105:
6100:
6095:
6085:
6084:
6080:
6079:
6056:
6055:
6053:
6052:
6042:
6041:
6036:
6029:Thrombopoietin
6026:
6021:
6016:
6011:
6006:
6001:
5996:
5991:
5986:
5972:
5967:
5962:
5957:
5950:Erythropoietin
5947:
5909:
5904:
5894:
5892:Adrenomedullin
5885:
5883:
5879:
5878:
5876:
5875:
5866:
5865:
5860:
5855:
5850:
5845:
5836:
5835:
5830:
5825:
5820:
5815:
5810:
5805:
5800:
5795:
5790:
5785:
5780:
5775:
5770:
5765:
5760:
5755:
5750:
5745:
5740:
5735:
5726:
5725:
5716:
5715:
5693:
5688:
5683:
5674:
5672:
5666:
5665:
5662:
5661:
5659:
5658:
5653:
5648:
5643:
5638:
5633:
5628:
5623:
5618:
5613:
5608:
5603:
5598:
5589:
5588:
5583:
5578:
5569:
5567:
5561:
5560:
5558:
5557:
5552:
5547:
5542:
5537:
5532:
5527:
5522:
5517:
5512:
5507:
5502:
5497:
5488:
5487:
5478:
5477:
5472:
5467:
5458:
5457:
5452:
5447:
5442:
5437:
5432:
5427:
5422:
5417:
5412:
5407:
5402:
5397:
5392:
5387:
5382:
5377:
5372:
5367:
5362:
5357:
5355:4'-DMA-7,8-DHF
5352:
5347:
5338:
5336:
5330:
5329:
5327:
5326:
5317:
5316:
5304:
5303:
5298:
5293:
5288:
5283:
5278:
5273:
5268:
5249:
5248:
5242:
5237:
5232:
5227:
5222:
5217:
5212:
5207:
5202:
5197:
5192:
5187:
5182:
5177:
5172:
5163:
5162:
5153:
5152:
5147:
5142:
5137:
5128:
5127:
5122:
5117:
5115:Gambogic amide
5112:
5107:
5102:
5097:
5092:
5087:
5078:
5076:
5067:
5061:
5060:
5058:
5057:
5049:
5047:
5041:
5040:
5038:
5037:
5032:
5027:
5022:
5017:
5012:
5007:
5002:
4997:
4992:
4987:
4978:
4977:
4972:
4963:
4961:
4955:
4954:
4951:
4950:
4948:
4947:
4938:
4936:
4932:
4931:
4929:
4928:
4919:
4918:
4909:
4907:
4901:
4900:
4898:
4897:
4888:
4887:
4885:Artemin (ARTN)
4878:
4876:
4870:
4869:
4867:
4866:
4857:
4856:
4847:
4845:
4839:
4838:
4836:
4835:
4826:
4825:
4820:
4811:
4809:
4800:
4794:
4793:
4791:
4790:
4785:
4780:
4771:
4770:
4765:
4760:
4755:
4750:
4745:
4740:
4735:
4730:
4725:
4720:
4715:
4710:
4705:
4700:
4695:
4686:
4685:
4663:
4654:
4652:
4646:
4645:
4643:
4642:
4633:
4632:
4620:
4619:
4614:
4609:
4604:
4599:
4594:
4589:
4584:
4572:
4571:
4566:
4561:
4556:
4547:
4546:
4541:
4536:
4531:
4526:
4521:
4516:
4511:
4506:
4497:
4495:
4489:
4488:
4485:
4484:
4482:
4481:
4476:
4467:
4466:
4428:
4426:
4422:
4421:
4419:
4418:
4412:
4403:
4402:
4392:
4390:
4384:
4383:
4381:
4380:
4374:
4369:
4364:
4359:
4354:
4349:
4344:
4339:
4330:
4329:
4324:
4319:
4314:
4309:
4300:
4299:
4294:
4289:
4284:
4279:
4274:
4269:
4259:
4257:
4248:
4242:
4241:
4239:
4238:
4233:
4228:
4223:
4218:
4213:
4208:
4199:
4198:
4193:
4188:
4183:
4178:
4173:
4168:
4163:
4158:
4153:
4148:
4143:
4138:
4133:
4128:
4123:
4118:
4113:
4108:
4103:
4094:
4093:
4084:
4083:
4078:
4068:
4066:
4060:
4059:
4056:
4055:
4053:
4052:
4043:
4041:
4037:
4036:
4034:
4033:
4028:
3994:
3985:
3983:
3977:
3976:
3974:
3973:
3963:
3962:
3957:
3952:
3947:
3913:
3904:
3902:
3896:
3895:
3893:
3892:
3883:
3882:
3877:
3868:
3867:
3862:
3857:
3852:
3847:
3842:
3780:
3771:
3769:
3763:
3762:
3760:
3759:
3754:
3749:
3744:
3739:
3697:
3688:
3686:
3677:
3671:
3670:
3667:
3666:
3664:
3663:
3637:
3632:
3627:
3618:
3616:
3610:
3609:
3607:
3606:
3601:
3596:
3587:
3586:
3564:
3562:
3556:
3555:
3553:
3552:
3547:
3542:
3537:
3532:
3523:
3522:
3517:
3512:
3507:
3502:
3497:
3488:
3487:
3477:
3475:
3469:
3468:
3466:
3465:
3460:
3455:
3450:
3445:
3440:
3435:
3430:
3425:
3420:
3411:
3410:
3405:
3400:
3395:
3390:
3385:
3380:
3375:
3370:
3365:
3360:
3355:
3350:
3345:
3336:
3335:
3330:
3325:
3320:
3315:
3310:
3305:
3300:
3295:
3285:
3283:
3270:
3264:
3263:
3261:
3260:
3255:
3250:
3241:
3239:
3233:
3232:
3230:
3229:
3223:
3213:
3212:
3207:
3202:
3193:
3192:
3190:Angiopoietin 3
3187:
3185:Angiopoietin 2
3178:
3177:
3175:Angiopoietin 4
3172:
3170:Angiopoietin 1
3163:
3161:
3155:
3154:
3146:
3144:
3143:
3136:
3129:
3121:
3112:
3111:
3109:
3108:
3103:
3098:
3093:
3088:
3083:
3078:
3073:
3068:
3063:
3058:
3053:
3048:
3043:
3038:
3033:
3028:
3023:
3018:
3013:
3008:
3003:
2998:
2993:
2992:
2991:
2986:
2981:
2976:
2971:
2961:
2960:
2959:
2954:
2941:
2940:
2939:
2934:
2929:
2924:
2919:
2911:CDK inhibitors
2907:
2906:
2905:
2900:
2895:
2882:
2881:
2880:
2875:
2870:
2858:
2842:
2822:
2810:fusion protein
2805:
2803:
2799:
2798:
2795:
2794:
2792:
2791:
2790:
2789:
2784:
2779:
2774:
2769:
2756:
2755:
2754:
2753:
2748:
2743:
2726:
2725:
2724:
2723:
2718:
2713:
2708:
2695:
2694:
2693:
2692:
2687:
2682:
2677:
2672:
2667:
2662:
2649:
2648:
2642:
2630:
2629:
2628:
2627:
2622:
2617:
2612:
2607:
2602:
2597:
2584:
2582:
2576:
2575:
2573:
2572:
2551:
2550:
2549:(VEGFR, EGFR).
2505:
2504:
2503:
2502:
2497:
2492:
2479:
2478:
2477:
2476:
2471:
2466:
2461:
2456:
2451:
2446:
2441:
2436:
2431:
2426:
2421:
2416:
2403:
2402:
2386:
2380:
2375:
2370:
2365:
2360:
2355:
2350:
2330:
2329:
2328:
2327:
2322:
2317:
2307:HER1/EGFR and
2303:
2302:
2296:
2291:
2286:
2281:
2276:
2271:
2266:
2261:
2256:
2251:
2246:
2241:
2225:
2223:
2214:
2207:
2206:
2203:
2202:
2200:
2199:
2194:
2189:
2184:
2179:
2174:
2169:
2164:
2159:
2154:
2149:
2144:
2139:
2134:
2129:
2124:
2119:
2114:
2109:
2104:
2099:
2094:
2089:
2084:
2079:
2074:
2069:
2064:
2059:
2054:
2049:
2044:
2039:
2034:
2029:
2024:
2019:
2014:
2009:
2004:
1999:
1994:
1989:
1986:+hyaluronidase
1979:
1973:
1971:
1967:
1966:
1964:
1963:
1946:
1945:
1919:
1914:
1909:
1904:
1899:
1894:
1860:
1858:
1848:
1847:
1845:
1844:
1832:
1826:
1814:
1812:
1808:
1807:
1805:
1804:
1798:
1793:
1790:+hyaluronidase
1773:
1767:
1751:
1749:
1740:
1730:
1729:
1715:
1713:
1712:
1705:
1698:
1690:
1684:
1683:
1671:
1659:
1647:
1635:
1621:
1620:External links
1618:
1615:
1614:
1589:
1568:. 17 July 2017
1549:
1528:. 17 July 2017
1506:
1463:
1433:
1415:
1384:(7): 461–473.
1364:
1315:
1286:(1): 112–117.
1266:
1207:
1178:(4): 307–317.
1158:
1117:
1068:
1047:"Nerlynx EPAR"
1027:
980:
955:
926:
925:
923:
920:
915:
912:
881:
878:
873:
870:
864:
861:
851:
847:
816:
813:
805:p-glycoprotein
781:
778:
758:
755:
750:
747:
730:
727:
699:
698:
681:
680:
678:
677:
674:
672:
669:
661:
660:
659:
656:
655:
653:
652:
649:
641:
640:
639:
636:
635:
633:
632:
624:
622:
614:
613:
607:
601:
600:
597:
591:
582:
576:
571:
565:
564:
560:
559:
549:
541:
540:
538:
537:
529:DTXSID70220132
524:
522:
509:
508:
506:
505:
497:
495:
489:
488:
486:
485:
479:as salt:
477:
469:
467:
461:
460:
458:
457:
449:
447:
441:
440:
438:
437:
429:
427:
421:
420:
418:
417:
409:
407:
401:
400:
398:
397:
389:
387:
381:
380:
378:
377:
369:
367:
356:
355:
353:
352:
344:
342:
336:
335:
333:
332:
325:
317:
316:
315:
312:
311:
307:
306:
304:
303:
294:
282:
269:
258:
244:
242:
236:
235:
231:
230:
228:
227:
214:
212:
206:
205:
200:
194:
193:
188:
186:administration
180:
179:
177:
176:
174:
164:
162:
154:
153:
151:
150:
133:
116:
98:
96:
90:
89:
82:
76:
75:
68:
58:
57:
54:
50:
49:
46:
40:
39:
35:
34:
15:
13:
10:
9:
6:
4:
3:
2:
6145:
6134:
6131:
6129:
6126:
6124:
6121:
6119:
6118:Phenol ethers
6116:
6114:
6111:
6109:
6106:
6104:
6101:
6099:
6096:
6094:
6091:
6090:
6088:
6078:
6068:
6064:
6050:
6047:
6044:
6043:
6040:
6037:
6034:
6030:
6027:
6025:
6022:
6020:
6017:
6015:
6012:
6010:
6007:
6005:
6002:
6000:
5997:
5995:
5992:
5990:
5987:
5984:
5980:
5976:
5973:
5971:
5968:
5966:
5963:
5961:
5958:
5955:
5951:
5948:
5945:
5941:
5937:
5933:
5929:
5925:
5921:
5917:
5913:
5910:
5908:
5905:
5902:
5898:
5895:
5893:
5890:
5887:
5886:
5884:
5880:
5874:
5871:
5868:
5867:
5864:
5861:
5859:
5856:
5854:
5851:
5849:
5846:
5844:
5841:
5838:
5837:
5834:
5831:
5829:
5826:
5824:
5821:
5819:
5816:
5814:
5811:
5809:
5806:
5804:
5801:
5799:
5796:
5794:
5791:
5789:
5786:
5784:
5781:
5779:
5776:
5774:
5771:
5769:
5766:
5764:
5761:
5759:
5756:
5754:
5751:
5749:
5746:
5744:
5741:
5739:
5736:
5734:
5731:
5728:
5727:
5724:
5723:Cyclotraxin B
5721:
5718:
5717:
5713:
5709:
5705:
5701:
5697:
5694:
5692:
5689:
5687:
5684:
5682:
5679:
5676:
5675:
5673:
5671:
5667:
5657:
5654:
5652:
5649:
5647:
5644:
5642:
5639:
5637:
5636:Larotrectinib
5634:
5632:
5629:
5627:
5624:
5622:
5619:
5617:
5614:
5612:
5609:
5607:
5604:
5602:
5599:
5597:
5594:
5591:
5590:
5587:
5584:
5582:
5579:
5577:
5574:
5571:
5570:
5568:
5566:
5562:
5556:
5553:
5551:
5548:
5546:
5543:
5541:
5538:
5536:
5535:Larotrectinib
5533:
5531:
5528:
5526:
5523:
5521:
5518:
5516:
5513:
5511:
5508:
5506:
5503:
5501:
5498:
5496:
5493:
5490:
5489:
5486:
5483:
5480:
5479:
5476:
5473:
5471:
5470:Cyclotraxin B
5468:
5466:
5463:
5460:
5459:
5456:
5453:
5451:
5448:
5446:
5443:
5441:
5438:
5436:
5433:
5431:
5428:
5426:
5423:
5421:
5418:
5416:
5413:
5411:
5408:
5406:
5403:
5401:
5398:
5396:
5393:
5391:
5388:
5386:
5383:
5381:
5380:Amitriptyline
5378:
5376:
5373:
5371:
5368:
5366:
5363:
5361:
5358:
5356:
5353:
5351:
5348:
5346:
5343:
5340:
5339:
5337:
5335:
5331:
5325:
5322:
5319:
5318:
5315:
5312:
5309:
5306:
5305:
5302:
5299:
5297:
5294:
5292:
5289:
5287:
5284:
5282:
5279:
5277:
5274:
5272:
5269:
5267:
5264:
5260:
5257:
5256:Against TrkA:
5254:
5251:
5250:
5246:
5243:
5241:
5238:
5236:
5233:
5231:
5228:
5226:
5223:
5221:
5218:
5216:
5213:
5211:
5210:Larotrectinib
5208:
5206:
5203:
5201:
5198:
5196:
5193:
5191:
5188:
5186:
5183:
5181:
5178:
5176:
5173:
5171:
5168:
5165:
5164:
5161:
5158:
5155:
5154:
5151:
5148:
5146:
5143:
5141:
5140:Dexamethasone
5138:
5136:
5133:
5130:
5129:
5126:
5123:
5121:
5118:
5116:
5113:
5111:
5108:
5106:
5103:
5101:
5098:
5096:
5093:
5091:
5088:
5086:
5085:Amitriptyline
5083:
5080:
5079:
5077:
5075:
5071:
5068:
5066:
5062:
5055:
5051:
5050:
5048:
5046:
5042:
5036:
5033:
5031:
5028:
5026:
5023:
5021:
5018:
5016:
5013:
5011:
5008:
5006:
5003:
5001:
4998:
4996:
4993:
4991:
4988:
4986:
4983:
4980:
4979:
4976:
4973:
4971:
4968:
4965:
4964:
4962:
4960:
4956:
4946:
4943:
4940:
4939:
4937:
4933:
4927:
4924:
4921:
4920:
4917:
4914:
4911:
4910:
4908:
4906:
4902:
4896:
4893:
4890:
4889:
4886:
4883:
4880:
4879:
4877:
4875:
4871:
4865:
4862:
4859:
4858:
4855:
4852:
4849:
4848:
4846:
4844:
4840:
4834:
4831:
4828:
4827:
4824:
4821:
4819:
4816:
4813:
4812:
4810:
4808:
4804:
4801:
4799:
4795:
4789:
4786:
4784:
4781:
4779:
4776:
4773:
4772:
4769:
4766:
4764:
4761:
4759:
4756:
4754:
4751:
4749:
4746:
4744:
4741:
4739:
4736:
4734:
4731:
4729:
4726:
4724:
4721:
4719:
4716:
4714:
4711:
4709:
4706:
4704:
4701:
4699:
4696:
4694:
4691:
4688:
4687:
4683:
4679:
4675:
4671:
4667:
4664:
4662:
4659:
4656:
4655:
4653:
4651:
4647:
4641:
4638:
4635:
4634:
4631:
4628:
4625:
4622:
4621:
4618:
4615:
4613:
4610:
4608:
4605:
4603:
4600:
4598:
4595:
4593:
4590:
4588:
4585:
4583:
4580:
4577:
4574:
4573:
4570:
4567:
4565:
4562:
4560:
4559:Dexamethasone
4557:
4555:
4552:
4549:
4548:
4545:
4542:
4540:
4537:
4535:
4532:
4530:
4527:
4525:
4522:
4520:
4517:
4515:
4512:
4510:
4507:
4505:
4502:
4499:
4498:
4496:
4494:
4490:
4480:
4477:
4475:
4472:
4469:
4468:
4464:
4460:
4456:
4452:
4448:
4444:
4440:
4436:
4433:
4430:
4429:
4427:
4423:
4416:
4413:
4411:
4408:
4405:
4404:
4401:
4397:
4394:
4393:
4391:
4389:
4385:
4378:
4375:
4373:
4370:
4368:
4365:
4363:
4360:
4358:
4355:
4353:
4350:
4348:
4345:
4343:
4340:
4338:
4335:
4332:
4331:
4328:
4325:
4323:
4320:
4318:
4315:
4313:
4310:
4308:
4305:
4302:
4301:
4298:
4295:
4293:
4290:
4288:
4285:
4283:
4280:
4278:
4275:
4273:
4270:
4268:
4267:des(1-3)IGF-1
4264:
4261:
4260:
4258:
4256:
4252:
4249:
4247:
4243:
4237:
4234:
4232:
4231:Telisotuzumab
4229:
4227:
4224:
4222:
4219:
4217:
4214:
4212:
4209:
4207:
4204:
4201:
4200:
4197:
4194:
4192:
4189:
4187:
4184:
4182:
4179:
4177:
4174:
4172:
4169:
4167:
4164:
4162:
4159:
4157:
4154:
4152:
4149:
4147:
4144:
4142:
4139:
4137:
4134:
4132:
4129:
4127:
4124:
4122:
4119:
4117:
4114:
4112:
4109:
4107:
4104:
4102:
4099:
4096:
4095:
4092:
4089:
4088:Potentiators:
4086:
4085:
4082:
4079:
4077:
4073:
4070:
4069:
4067:
4065:
4061:
4051:
4048:
4045:
4044:
4042:
4038:
4032:
4029:
4026:
4022:
4018:
4014:
4010:
4006:
4002:
3998:
3995:
3993:
3990:
3987:
3986:
3984:
3982:
3978:
3971:
3968:
3965:
3964:
3961:
3958:
3956:
3953:
3951:
3950:Selpercatinib
3948:
3945:
3941:
3937:
3933:
3929:
3925:
3921:
3917:
3914:
3912:
3909:
3906:
3905:
3903:
3901:
3897:
3891:
3888:
3885:
3884:
3881:
3878:
3876:
3873:
3870:
3869:
3866:
3863:
3861:
3858:
3856:
3855:Selpercatinib
3853:
3851:
3848:
3846:
3843:
3840:
3836:
3832:
3828:
3824:
3820:
3816:
3812:
3808:
3804:
3800:
3796:
3792:
3788:
3784:
3781:
3779:
3776:
3773:
3772:
3770:
3768:
3764:
3758:
3755:
3753:
3750:
3748:
3747:Selpercatinib
3745:
3743:
3740:
3737:
3733:
3729:
3725:
3721:
3717:
3713:
3709:
3705:
3701:
3698:
3696:
3693:
3690:
3689:
3687:
3685:
3681:
3678:
3676:
3672:
3661:
3657:
3653:
3649:
3645:
3641:
3638:
3636:
3633:
3631:
3628:
3626:
3623:
3620:
3619:
3617:
3615:
3611:
3605:
3602:
3600:
3597:
3595:
3592:
3589:
3588:
3584:
3580:
3576:
3572:
3569:
3566:
3565:
3563:
3561:
3557:
3551:
3548:
3546:
3543:
3541:
3538:
3536:
3533:
3531:
3528:
3525:
3524:
3521:
3518:
3516:
3513:
3511:
3508:
3506:
3503:
3501:
3498:
3496:
3493:
3490:
3489:
3486:
3482:
3479:
3478:
3476:
3474:
3470:
3464:
3461:
3459:
3456:
3454:
3451:
3449:
3446:
3444:
3441:
3439:
3436:
3434:
3431:
3429:
3426:
3424:
3423:Depatuxizumab
3421:
3419:
3416:
3413:
3412:
3409:
3406:
3404:
3401:
3399:
3396:
3394:
3391:
3389:
3386:
3384:
3381:
3379:
3376:
3374:
3371:
3369:
3366:
3364:
3361:
3359:
3356:
3354:
3351:
3349:
3346:
3344:
3341:
3338:
3337:
3334:
3331:
3329:
3326:
3324:
3321:
3319:
3316:
3314:
3311:
3309:
3306:
3304:
3301:
3299:
3296:
3294:
3290:
3287:
3286:
3284:
3282:
3274:
3271:
3269:
3265:
3259:
3256:
3254:
3251:
3249:
3246:
3243:
3242:
3240:
3238:
3234:
3227:
3224:
3221:
3218:
3215:
3214:
3211:
3208:
3206:
3203:
3201:
3198:
3195:
3194:
3191:
3188:
3186:
3183:
3180:
3179:
3176:
3173:
3171:
3168:
3165:
3164:
3162:
3160:
3156:
3152:
3149:
3142:
3137:
3135:
3130:
3128:
3123:
3122:
3119:
3107:
3104:
3102:
3099:
3097:
3094:
3092:
3089:
3087:
3084:
3082:
3079:
3077:
3074:
3072:
3069:
3067:
3064:
3062:
3059:
3057:
3054:
3052:
3049:
3047:
3044:
3042:
3039:
3037:
3034:
3032:
3029:
3027:
3024:
3022:
3021:Larotrectinib
3019:
3017:
3014:
3012:
3009:
3007:
3004:
3002:
2999:
2997:
2994:
2990:
2987:
2985:
2982:
2980:
2977:
2975:
2972:
2970:
2967:
2966:
2965:
2962:
2958:
2955:
2953:
2950:
2949:
2948:
2946:
2942:
2938:
2935:
2933:
2930:
2928:
2925:
2923:
2920:
2918:
2915:
2914:
2913:
2912:
2908:
2904:
2901:
2899:
2896:
2894:
2891:
2890:
2889:
2887:
2883:
2879:
2876:
2874:
2873:Ridaforolimus
2871:
2869:
2866:
2865:
2864:
2863:
2859:
2856:
2852:
2851:
2847:
2843:
2840:
2836:
2835:
2831:
2827:
2823:
2820:
2816:
2815:
2811:
2807:
2806:
2804:
2800:
2788:
2785:
2783:
2782:Pirtobrutinib
2780:
2778:
2777:Orelabrutinib
2775:
2773:
2770:
2768:
2767:Acalabrutinib
2765:
2764:
2763:
2762:
2758:
2757:
2752:
2749:
2747:
2744:
2742:
2739:
2738:
2737:
2736:
2732:
2728:
2727:
2722:
2719:
2717:
2714:
2712:
2709:
2707:
2704:
2703:
2702:
2701:
2697:
2696:
2691:
2688:
2686:
2683:
2681:
2678:
2676:
2673:
2671:
2668:
2666:
2663:
2661:
2658:
2657:
2656:
2655:
2651:
2650:
2646:
2643:
2641:
2637:
2636:
2632:
2631:
2626:
2623:
2621:
2618:
2616:
2613:
2611:
2608:
2606:
2603:
2601:
2598:
2596:
2593:
2592:
2591:
2590:
2586:
2585:
2583:
2581:
2577:
2570:
2566:
2562:
2559:
2557:
2553:
2552:
2548:
2544:
2543:Selpercatinib
2540:
2539:Repotrectinib
2536:
2532:
2528:
2527:Larotrectinib
2524:
2520:
2516:
2513:
2511:
2507:
2506:
2501:
2498:
2496:
2493:
2491:
2488:
2487:
2486:
2485:
2481:
2480:
2475:
2472:
2470:
2467:
2465:
2462:
2460:
2457:
2455:
2452:
2450:
2447:
2445:
2442:
2440:
2437:
2435:
2432:
2430:
2427:
2425:
2422:
2420:
2417:
2415:
2412:
2411:
2410:
2409:
2405:
2404:
2400:
2396:
2392:
2391:
2387:
2384:
2381:
2379:
2376:
2374:
2371:
2369:
2366:
2364:
2361:
2359:
2356:
2354:
2351:
2349:
2345:
2344:
2340:
2335:
2334:RTK class III
2332:
2331:
2326:
2323:
2321:
2318:
2316:
2313:
2312:
2311:
2310:
2305:
2304:
2300:
2297:
2295:
2292:
2290:
2287:
2285:
2282:
2280:
2277:
2275:
2272:
2270:
2267:
2265:
2262:
2260:
2257:
2255:
2252:
2250:
2247:
2245:
2242:
2240:
2236:
2235:
2230:
2227:
2226:
2224:
2222:
2218:
2215:
2212:
2208:
2198:
2195:
2193:
2190:
2188:
2185:
2183:
2180:
2178:
2175:
2173:
2170:
2168:
2165:
2163:
2160:
2158:
2155:
2153:
2150:
2148:
2145:
2143:
2140:
2138:
2135:
2133:
2130:
2128:
2125:
2123:
2120:
2118:
2117:Pembrolizumab
2115:
2113:
2110:
2108:
2105:
2103:
2100:
2098:
2095:
2093:
2090:
2088:
2085:
2083:
2082:Mogamulizumab
2080:
2078:
2075:
2073:
2070:
2068:
2065:
2063:
2060:
2058:
2055:
2053:
2050:
2048:
2045:
2043:
2040:
2038:
2035:
2033:
2030:
2028:
2025:
2023:
2020:
2018:
2015:
2013:
2010:
2008:
2005:
2003:
2000:
1998:
1995:
1993:
1990:
1987:
1983:
1980:
1978:
1975:
1974:
1972:
1968:
1961:
1957:
1956:
1951:
1948:
1947:
1943:
1939:
1938:
1933:
1929:
1928:
1923:
1920:
1918:
1915:
1913:
1910:
1908:
1905:
1903:
1902:Mosunetuzumab
1900:
1898:
1895:
1893:
1889:
1888:
1883:
1882:Mosunetuzumab
1879:
1875:
1871:
1870:
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1590:
1586:
1585:public domain
1567:
1565:
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1553:
1550:
1546:
1545:public domain
1527:
1525:
1519:
1513:
1511:
1507:
1503:
1502:public domain
1484:
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985:
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965:
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943:
942:
941:Health Canada
937:
931:
928:
921:
919:
913:
911:
908:
906:
902:
897:
895:
891:
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688:
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623:
620:
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608:
606:
602:
572:
570:
566:
561:
557:
553:
550:
548:
546:ECHA InfoCard
542:
534:
530:
526:
525:
523:
514:
510:
503:
499:
498:
496:
494:
490:
483:
478:
475:
471:
470:
468:
466:
462:
455:
451:
450:
448:
446:
442:
435:
431:
430:
428:
426:
422:
415:
411:
410:
408:
406:
402:
395:
391:
390:
388:
386:
382:
375:
371:
370:
368:
361:
357:
350:
346:
345:
343:
341:
337:
329:
324:
320:
313:
308:
302: Rx-only
295:
293:
283:
280:
270:
268:
259:
256:
246:
245:
243:
241:
237:
232:
224:
219:
216:
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213:
211:
207:
204:
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175:
166:
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134:
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126:
117:
114:
109:
100:
99:
97:
95:
91:
87:
83:
81:
77:
73:
69:
67:
63:
59:
55:
51:
47:
45:
41:
38:Clinical data
36:
32:
27:
19:
6108:Chloroarenes
6103:Carboxamides
6049:Cerebrolysin
6045:
6019:Pleiotrophin
5975:Interleukins
5888:
5869:
5839:
5758:Fruquintinib
5748:Cabozantinib
5729:
5719:
5677:
5641:Lestaurtinib
5592:
5572:
5540:Lestaurtinib
5491:
5481:
5462:Antagonists:
5461:
5395:Deoxygedunin
5350:3,7,8,2'-THF
5341:
5320:
5311:Against NGF:
5310:
5307:
5263:Against NGF:
5262:
5255:
5252:
5215:Lestaurtinib
5166:
5156:
5150:Testosterone
5132:Antagonists:
5131:
5081:
4981:
4966:
4941:
4922:
4912:
4891:
4881:
4860:
4850:
4829:
4814:
4774:
4689:
4657:
4636:
4627:Against NGF:
4626:
4623:
4579:Against NGF:
4578:
4575:
4569:Testosterone
4551:Antagonists:
4550:
4500:
4470:
4431:
4406:
4395:
4372:Teprotumumab
4333:
4303:
4262:
4211:Ficlatuzumab
4206:Emibetuzumab
4202:
4156:JNJ-38877605
4126:Cabozantinib
4097:
4087:
4076:Fosgonimeton
4071:
4046:
3988:
3966:
3907:
3890:Infigratinib
3886:
3871:
3774:
3691:
3625:Betacellulin
3621:
3604:Seribantumab
3590:
3567:
3544:
3526:
3491:
3485:Unknown/none
3484:
3480:
3414:
3392:
3339:
3298:Betacellulin
3293:Amphiregulin
3288:
3280:(ErbB1/HER1)
3244:
3216:
3196:
3182:Antagonists:
3181:
3166:
3159:Angiopoietin
3061:Pexidartinib
3046:Odronextamab
3016:Gilteritinib
2996:Cabozantinib
2943:
2909:
2884:
2878:Temsirolimus
2860:
2844:
2826:proapoptotic
2824:
2808:
2787:Zanubrutinib
2759:
2729:
2698:
2675:Lestaurtinib
2654:Janus kinase
2652:
2633:
2587:
2580:Non-receptor
2561:Cabozantinib
2554:
2523:Infigratinib
2508:
2482:
2424:Fruquintinib
2406:
2399:Gilteritinib
2395:Lestaurtinib
2388:
2337:
2319:
2306:
2279:Mobocertinib
2244:Aumolertinib
2232:
2197:Tremelimumab
2182:Tislelizumab
2137:Retifanlimab
2012:Blinatumomab
1982:Atezolizumab
1953:
1935:
1925:
1907:Obinutuzumab
1885:
1867:
1834:
1817:
1775:
1758:
1674:
1666:
1654:
1642:
1630:
1605:. Retrieved
1602:medex.com.bd
1601:
1592:
1570:. Retrieved
1561:
1552:
1530:. Retrieved
1521:
1487:. Retrieved
1478:
1454:. Retrieved
1445:
1436:
1427:
1418:
1381:
1377:
1367:
1332:
1328:
1318:
1283:
1279:
1269:
1224:
1220:
1210:
1175:
1171:
1161:
1134:
1130:
1120:
1085:
1081:
1071:
1058:. Retrieved
1050:
1018:. Retrieved
1013:
971:. Retrieved
967:
958:
946:. Retrieved
939:
930:
917:
909:
898:
883:
875:
866:
863:Cell Biology
845:
818:
815:Pharmacology
798:
783:
780:Interactions
775:
767:liver damage
760:
752:
743:capecitabine
740:
732:
729:Medical uses
723:
711:
703:
702:
691:
685:
502:ChEMBL180022
327:
240:Legal status
234:Legal status
94:License data
18:
6009:Oncomodulin
5873:Aflibercept
5863:Ranibizumab
5858:Ramucirumab
5848:Bevacizumab
5840:Antibodies:
5798:Regorafenib
5738:Altiratinib
5651:ONO-5390556
5621:Entrectinib
5596:Altiratinib
5550:ONO-5390556
5520:Entrectinib
5495:Altiratinib
5281:Frunevetmab
5253:Antibodies:
5230:ONO-5390556
5195:Entrectinib
5170:Altiratinib
5125:Tavilermide
5020:Quizartinib
4959:SCF (c-Kit)
4783:Ramucirumab
4775:Antibodies:
4748:Quizartinib
4698:Avapritinib
4661:Becaplermin
4597:Frunevetmab
4576:Antibodies:
4479:Trofinetide
4410:Dusigitumab
4407:Antibodies:
4362:Robatumumab
4352:Figitumumab
4347:Dalotuzumab
4342:Cixutumumab
4334:Antibodies:
4226:Rilotumumab
4221:Onartuzumab
4216:Flanvotumab
4203:Antibodies:
4171:PF-04217903
4101:Altiratinib
4064:HGF (c-Met)
3967:Antibodies:
3872:Antibodies:
3594:Duligotumab
3591:Antibodies:
3505:Trastuzumab
3495:Ertumaxomab
3492:Antibodies:
3463:Zalutumumab
3458:Panitumumab
3453:Nimotuzumab
3448:Necitumumab
3438:Imgatuzumab
3415:Antibodies:
3398:Osimertinib
3363:Dacomitinib
3258:Dapiclermin
3217:Antibodies:
3200:Altiratinib
3091:Tebentafusp
3071:Regorafenib
3066:Quizartinib
3056:Pemigatinib
3036:Midostaurin
3011:Erdafitinib
3006:Entrectinib
2989:Parsaclisib
2937:Trilaciclib
2927:Palbociclib
2922:Dalpiciclib
2917:Abemaciclib
2819:Aflibercept
2746:Entrectinib
2716:Selumetinib
2711:Cobimetinib
2706:Binimetinib
2690:Ruxolitinib
2680:Momelotinib
2660:Baricitinib
2558:inhibitors:
2535:Pralsetinib
2531:Pemigatinib
2519:Futibatinib
2515:Entrectinib
2512:inhibitors:
2444:Regorafenib
2348:Avapritinib
2294:Rociletinib
2289:Osimertinib
2254:Dacomitinib
2192:Toripalimab
2177:Teclistamab
2167:Talquetamab
2162:Tafasitamab
2157:Sugemalimab
2152:Serplulimab
2142:Sabatolimab
2132:Ramucirumab
2127:Prolgolimab
2097:Necitumumab
2052:Epcoritamab
2032:Dostarlimab
2022:Daratumumab
1977:Amivantamab
1942:Alemtuzumab
1932:Brentuximab
1922:Tositumomab
1897:Ibritumomab
1878:Elranatamab
1841:Bevacizumab
1829:Edrecolomab
1824:Catumaxomab
1786:Trastuzumab
1770:Panitumumab
1676:NCT00878709
1627:"Neratinib"
1572:13 November
1532:13 November
1489:13 November
1456:13 November
1088:: 113–122.
1060:13 November
1020:13 November
973:13 November
914:Brand names
831:(Her2) and
771:eosinophils
612: g·mol
552:100.241.512
349:698387-09-6
310:Identifiers
80:MedlinePlus
53:Other names
44:Trade names
6128:Quinolines
6087:Categories
5828:Vandetanib
5793:Rebastinib
5788:Pegaptanib
5778:Nintedanib
5768:Lenvatinib
5733:Agerafenib
5686:Ripretinib
5611:CH-7057288
5510:CH-7057288
5375:7,8,3'-THF
5370:7,8,2'-THF
5296:Ranevetmab
5286:Fulranumab
5240:Rebastinib
5185:CH-7057288
5100:Cenegermin
4985:Agerafenib
4945:Agerafenib
4926:Vandetanib
4895:Vandetanib
4864:Vandetanib
4833:Vandetanib
4778:Olaratumab
4753:Ripretinib
4733:Nintedanib
4718:Lenvatinib
4708:Crenolanib
4693:Agerafenib
4612:Ranevetmab
4602:Fulranumab
4519:Cenegermin
4493:LNGF (p75)
4415:Xentuzumab
4377:Xentuzumab
4322:NVP-AEW541
4317:NVP-ADW742
4312:Linsitinib
4307:BMS-754807
4292:Mecasermin
4191:Tivantinib
4181:PHA-665752
4176:PF-2341066
4146:Golvatinib
4136:Crizotinib
4131:Capmatinib
4121:BMS-777607
4116:Amuvatinib
3992:Ersofermin
3955:Sprifermin
3911:Ersofermin
3860:Sprifermin
3850:Repifermin
3845:Palifermin
3778:Ersofermin
3757:Velafermin
3742:Repifermin
3695:Ersofermin
3614:ErbB4/HER4
3599:Patritumab
3560:ErbB3/HER3
3540:Mubritinib
3500:Pertuzumab
3473:ErbB2/HER2
3403:Vandetanib
3358:Canertinib
3353:Brigatinib
3348:Agerafenib
3328:Nepidermin
3323:Murodermin
3313:Epiregulin
3268:EGF (ErbB)
3226:Nesvacumab
3220:Evinacumab
3210:Rebastinib
3151:modulators
3106:Venetoclax
3101:Vandetanib
3076:Ripretinib
3041:Nintedanib
3026:Lenvatinib
3001:Capmatinib
2984:Idelalisib
2974:Copanlisib
2947:inhibitors
2932:Ribociclib
2903:Vismodegib
2888:inhibitors
2868:Everolimus
2834:prohibitin
2751:Lorlatinib
2741:Crizotinib
2721:Trametinib
2685:Pacritinib
2670:Filgotinib
2665:Fedratinib
2569:Crizotinib
2565:Capmatinib
2547:Vandetanib
2495:Brigatinib
2474:Vandetanib
2434:Nintedanib
2429:Lenvatinib
2368:Ripretinib
2299:Vandetanib
2274:Lazertinib
2249:Brigatinib
2172:Tarlatamab
2107:Olaratumab
2067:Isatuximab
2062:Ipilimumab
2042:Elotuzumab
2037:Durvalumab
2017:Cemiplimab
2007:Bermekimab
1997:Axatilimab
1912:Ofatumumab
1892:Glofitamab
1874:Glofitamab
1782:Pertuzumab
922:References
617:3D model (
605:Molar mass
454:JJH94R3PWB
425:ChemSpider
385:IUPHAR/BPS
340:CAS Number
319:IUPAC name
198:Drug class
5853:Icrucumab
5833:WHI-P 154
5823:Tivozanib
5818:Toceranib
5813:Sunitinib
5808:Sorafenib
5803:Semaxanib
5783:Pazopanib
5773:Motesanib
5763:Lapatinib
5753:Cediranib
5691:Telbermin
5678:Agonists:
5626:GZ-389988
5606:CE-245677
5573:Agonists:
5525:GZ-389988
5505:CE-245677
5405:Diosmetin
5342:Agonists:
5308:Aptamers:
5301:Tanezumab
5276:Fasinumab
5220:Milciclib
5200:GZ-389988
5180:CE-245677
5082:Agonists:
5035:Toceranib
5030:Sunitinib
5025:Sorafenib
5015:Pazopanib
5010:Nilotinib
5005:Masitinib
4995:Dasatinib
4967:Agonists:
4913:Agonists:
4882:Agonists:
4851:Agonists:
4823:Liatermin
4815:Agonists:
4798:RET (GFL)
4788:Tovetumab
4768:Toceranib
4763:Sorafenib
4758:Sunitinib
4743:Radotinib
4738:Pazopanib
4728:Motesanib
4723:Masitinib
4658:Agonists:
4624:Aptamers:
4617:Tanezumab
4592:Fasinumab
4501:Agonists:
4357:Ganitumab
4277:IGF-1 LR3
4196:Volitinib
4151:INCB28060
4141:Foretinib
4047:Agonists:
4031:Trafermin
3989:Agonists:
3970:Burosumab
3960:Trafermin
3908:Agonists:
3875:Aprutumab
3865:Trafermin
3827:10 (KGF2)
3775:Agonists:
3752:Trafermin
3732:10 (KGF2)
3692:Agonists:
3622:Agonists:
3568:Agonists:
3550:Tucatinib
3545:Neratinib
3535:Lapatinib
3443:Matuzumab
3433:Futuximab
3418:Cetuximab
3408:WHI-P 154
3393:Neratinib
3388:Lapatinib
3378:Grandinin
3373:Gefitinib
3368:Erlotinib
3245:Agonists:
3205:CE-245677
3167:Agonists:
3096:Tepotinib
3086:Sunitinib
3081:Sorafenib
3051:Pazopanib
3031:Masitinib
2979:Duvelisib
2969:Alpelisib
2957:Sotorasib
2952:Adagrasib
2898:Sonidegib
2893:Glasdegib
2839:Adipotide
2772:Ibrutinib
2645:Dasatinib
2640:Bosutinib
2625:Radotinib
2620:Ponatinib
2615:Nilotinib
2605:Dasatinib
2600:Bosutinib
2595:Asciminib
2563:(VEGFR),
2521:(FGFR2),
2500:Ceritinib
2490:Alectinib
2469:Toceranib
2464:Tivozanib
2459:Sunitinib
2454:Sorafenib
2449:Semaxanib
2439:Pazopanib
2419:Cediranib
2383:Toceranib
2378:Sunitinib
2373:Sorafenib
2363:Pazopanib
2358:Masitinib
2325:Tucatinib
2320:Neratinib
2315:Lapatinib
2284:Olmutinib
2264:Gefitinib
2259:Erlotinib
2234:HER1/EGFR
2102:Nivolumab
2092:Naxitamab
1917:Rituximab
1765:Cetuximab
1760:HER1/EGFR
896:in 2011.
872:Chemistry
821:lapatinib
735:indicated
704:Neratinib
184:Routes of
158:Pregnancy
130:Neratinib
72:Monograph
66:Drugs.com
23:Neratinib
6113:Nitriles
6077:Medicine
6035:instead)
6024:Renalase
5985:instead)
5956:instead)
5903:instead)
5743:Axitinib
5712:D (FIGF)
5656:PLX-7486
5646:ONO-4474
5601:AZD-6918
5555:PLX-7486
5545:ONO-4474
5500:AZD-6918
5482:Ligands:
5400:Deprenyl
5360:7,3'-DHF
5291:MEDI-578
5271:ASP-6294
5235:PLX-7486
5225:ONO-4474
5175:AZD-6918
5135:ALE-0540
5056:instead.
5000:Imatinib
4990:Axitinib
4970:Ancestim
4935:Unsorted
4713:Imatinib
4703:Axitinib
4607:MEDI-578
4587:ASP-6294
4554:ALE-0540
4396:Agonists
4337:AVE-1642
4263:Agonists
4186:SU-11274
4072:Agonists
4050:FGF15/19
4040:Unsorted
4005:2 (bFGF)
3924:2 (bFGF)
3791:2 (bFGF)
3708:2 (bFGF)
3530:Afatinib
3481:Agonists
3383:Icotinib
3343:Afatinib
3289:Agonists
2886:hedgehog
2848:against
2846:exotoxin
2812:against
2761:Bruton's
2610:Imatinib
2533:(FGFR),
2529:(NTRK),
2414:Axitinib
2353:Axitinib
2309:HER2/neu
2269:Icotinib
2239:Afatinib
2213:("-nib")
1992:Avelumab
1864:lymphoid
1856:lymphoma
1852:Leukemia
1777:HER2/neu
1739:("-mab")
1598:"Hernix"
1410:34126793
1359:26352907
1310:26260909
1261:18227510
1194:21455239
1153:17311002
1131:Oncogene
1112:29042085
1014:DailyMed
825:afatinib
794:antacids
694:(verify)
405:DrugBank
210:ATC code
191:By mouth
160:category
125:DailyMed
5912:Ephrins
5616:DS-6051
5515:DS-6051
5420:LM22A-4
5410:DMAQ-B1
5365:7,8-DHF
5345:3,7-DHF
5314:RBM-004
5259:GBR-900
5190:DS-6051
5160:VM-902A
4630:RBM-004
4327:OSl-906
4287:Insulin
4166:MK-2461
4111:AMG-458
3248:Axokine
2589:bcr-abl
1950:myeloid
1607:14 July
1401:8246527
1350:4583831
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