20:
280:
4704:
5342:
207:
4714:
385:
413:, India, in April 2010. As previously, the bacteria were fully resistant to all the aminoglycoside, β-lactam, and quinolone antibiotics, but were susceptible to tigecycline and colistin. This particularly broad spectrum of antibiotic resistance was heightened by the strain's expressing several different resistance genes in addition to
535:
universities found NDM-1 in two wastewater treatment plants in northern China. In fact, the NDM-1 was unable to be removed after several treatments and attempts to disinfect the plants. Disinfection by chlorine, one of the most effective methods currently, also failed to eradicate the beta-lactamase.
630:
blamed the emergence of this gene on the widespread misuse of antibiotics in the Indian healthcare system, stating that Indian doctors have "not yet taken the issue of antibiotic resistance seriously" and noting little control over the prescription of antibiotics by doctors and even pharmacists. The
501:
On 6 September 2010, Japan detected its first ever case of the NDM-1 enzyme. In May 2009, a
Japanese man in his 50s who had recently returned from vacation in India was struck with a fever and hospitalized, later making a full recovery. Hospital officials confirmed that tests carried out after the
505:
An environmental point prevalence study conducted between 26 September and 10 October 2010 found bacteria with the NDM-1 gene in drinking water and seepage samples in New Delhi. 50 tap water samples and 171 seepage samples were collected from sites within 12 km of central New Delhi. Of these
688:. A doctor involved in his treatment said: "He was involved in a car accident during a trip to Pakistan. He was hospitalised with a major leg injury and then repatriated to Belgium, but he was already infected". In another case, an Indian citizen, died in a hospital because of similar infection.
313:. The authors concluded that the new resistance mechanism "clearly arose in India, but there are few data arising from India to suggest how widespread it is". Its exact geographical origin, however, has not been conclusively verified. In March 2010, a study in a hospital in
247:
Carbapenemases are particularly dangerous resistance mechanisms, since they can inactivate a wide range of different antibiotics. The NDM-1 enzyme is one of the class B metallo-beta-lactamase; other types of carbapenemase are class A or class D beta-lactamases. (The class A
605:
study that the gene originated in India, describing this conclusion as "unfair" and stating that Indian hospitals are perfectly safe for treatment. Indian politicians have described linking this new drug resistance gene to India as "malicious propaganda" and blamed
287:
NDM-1 functions through two zinc ions present in the active site that cause hydrolysis of the beta-lactams, rendering them ineffective. Experimental data has shown that zinc chelators can prevent the hydrolysis of beta-lactams mediated by metallo-beta-lactamases.
614:
politician has instead argued that the journal article is bogus and represented an attempt to scare medical tourists away from India. The Indian
Ministry of Health released a statement "strongly refut" naming the enzyme "New Delhi". A co-author of the 2010
377:(CDC) stated that "All three U.S. isolates were from patients having received recent medical care in India." However, US experts stated that it is unclear as to whether this strain is any more dangerous than existing antibiotic-resistant bacteria such as
300:, the capital city of India, as it was first described by Yong et al. in December 2009 in a Swedish national who fell ill with an antibiotic-resistant bacterial infection that he acquired in India. The infection was identified as a carbapenem-resistant
938:
547:
fungus turns off the resistance mechanism of NDM-1 and thus makes bacteria once again sensitive to traditional antibiotics. It has been shown to be effective in mice and rats but has not yet been tested in humans for safety or effectiveness.
1610:
Walsh, Timothy R; Weeks, Janis; Livermore, David M; Toleman, Mark A (May 2011). "Dissemination of NDM-1 positive bacteria in the New Delhi environment and its implications for human health: an environmental point prevalence study".
1671:
Luo, Yi; Yang, Fengxia; Mathieu, Jacques; Mao, Daqing; Wang, Qing; Alvarez, P. J. J. (2014). "Proliferation of
Multidrug-Resistant New Delhi Metallo-β-lactamase Genes in Municipal Wastewater Treatment Plants in Northern China".
1261:
Principe, Luigi; Vecchio, Graziella; Sheehan, Gerard; Kavanagh, Kevin; Morroni, Gianluca; Viaggi, Valentina; di Masi, Alessandra; Giacobbe, Daniele
Roberto; Luzzaro, Francesco; Luzzati, Roberto; Di Bella, Stefano (2020-10-01).
577:
to decrease their activity. The
Modified Hodge Test and the Re-Modified Hodge Test were developed for phenotypical detection on a routine basis in resource limited laboratories. Other tests for phenotypic detection are:
1225:
Cuzon, G.; Naas, T.; Nordmann, P. (February 2010). "Carbapénèmases de type KPC : quel enjeu en microbiologie clinique ?" [KPC carbapenemases: what is at stake in clinical microbiology?].
4750:
1322:"Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India"
644:
refused to publish a rebuttal from the Indian
National Centre for Disease Control, claiming lack of space and that the journal's editors felt it would be better placed elsewhere. However, on 12
366:. The authors warned that international travel and patients' use of multiple countries' healthcare systems could lead to the "rapid spread of NDM-1 with potentially serious consequences".
635:
states that there is general agreement among experts that India needs both an improved policy to control the use of antibiotics and a central registry of antibiotic-resistant infections.
515:
strain. The patient contracted the bacteria after another patient, who had surgery on the Indian subcontinent, traveled to Canada and was admitted to hospital with an infection.
4743:
262:, United States, in 1996 and has since spread worldwide. A later publication indicated that Enterobacteriaceae that produce KPC were becoming common in the United States.)
2245:
2072:
1866:
4736:
509:
On 8 May 2012, the presence of NDM was found in a patient who died at Royal
Alexandra Hospital in Edmonton, Alberta. The patient was also found to be carrying an
598:
498:. These confirmed NDM-1 infected cases have no relationship with New Delhi, India. The patients or their relatives never travelled to India in the last decade.
4109:
3618:
3049:
2611:
2387:
1884:
718:
378:
374:
1942:
1920:
569:
Detection of NDM-1 gene depends upon the phenotypic determination of the enzyme activity. These enzymes are zinc dependent and therefore termed as
1646:
4979:
2238:
1424:
708:
2003:
822:
Indian
Network for Surveillance of Antimicrobial Resistance (INSAR) group (webappendix) (November 2010). "New Delhi metallo-β-lactamase 1".
2086:
1000:"Methicillin-Resistant Staphylococcus aureus and New Delhi Metallo beta-lactamases- types of antibiotic resistance, methods of prevention"
939:"Colonization of intestinal microbiota with carbapenemase-producing Enterobacteriaceae in paediatric intensive care units in Cairo, Egypt"
2108:
664:, demanded that such 'geographic names giving' be abandoned and replaced by 'scientific name giving'. He proposed changing NDM-1 to PCM (
133:
family, which are a mainstay for the treatment of antibiotic-resistant bacterial infections. The gene for NDM-1 is one member of a large
1902:
570:
761:"Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study"
4410:
4150:
1737:
506:
samples, 20 strains of bacteria were found to contain NDM-1 gene in 51 out of 171 seepage samples and 2 out of 50 tap water samples.
5382:
5061:
1753:"Notes from the Field: Pan-Resistant New Delhi Metallo-Beta-Lactamase-Producing Klebsiella pneumoniae — Washoe County, Nevada, 2016"
906:
358:. In initial assays the bacterium was fully resistant to all antibiotics tested, while later tests found that it was susceptible to
5372:
2283:
2231:
354:
in the United
Kingdom. The patient was a man of Indian origin who had visited India 18 months previously, where he had undergone
4400:
4327:
2278:
49:
4954:
4524:
4255:
425:
217:
are a class of beta-lactam antibiotics that are capable of killing most bacteria by inhibiting the synthesis of one of their
5217:
1370:
4643:
4117:
623:, has stated that he does not agree with the part of the article that advises people to avoid elective surgeries in India.
2362:
2352:
2335:
1104:
5332:
573:. Indian studies have been done which demonstrate their dependency on zinc and the ability of zinc chelating agents like
1190:
Nordmann P, Cuzon G, Naas T (April 2009). "The real threat of
Klebsiella pneumoniae carbapenemase-producing bacteria".
937:
Ghaith, Doaa M.; Mohamed, Zeinat K.; Farahat, Mohamed G.; Aboulkasem Shahin, Walaa; Mohamed, Hadeel O. (2019-03-01).
276:
from populations of antibiotic-sensitive bacteria, which will be diminished by the original antibacterial treatment.
1264:"Zinc Chelators as Carbapenem Adjuvants for Metallo-β-Lactamase-Producing Bacteria: In Vitro and In Vivo Evaluation"
5362:
4916:
4365:
5202:
5318:
5305:
5292:
5279:
5266:
5253:
5240:
5014:
4991:
4926:
4893:
4860:
4772:
2767:
1574:
607:
273:
5212:
5166:
5109:
4763:
4519:
4442:
4405:
4201:
460:
195:
3634:
272:), therefore, aids the expansion of bacteria that carry it throughout a human host, since they will face less
1371:"New Delhi Metallo-β lactamase (NDM-1) in Enterobacteriaceae: Treatment options with Carbapenems Compromised"
5114:
4833:
4086:
3930:
3726:
2367:
1535:"Coexistence of blaOXA-23 with blaNDM-1 and armA in clinical isolates of Acinetobacter baumannii from India"
736:
653:
561:. She had been on an extended trip to India and was admitted to a hospital there for an infected right hip.
398:
2998:
2218:
4595:
4514:
4493:
4143:
3911:
3118:
3098:
2582:
611:
490:, Canada, had its first confirmed case of the "superbug" in Brampton. There were other confirmed cases in
464:
336:
181:
126:
3550:
3451:
676:
The first reported death due to bacteria expressing the NDM-1 enzyme was recorded in August 2010, when a
5367:
5135:
5054:
4635:
4277:
3444:
3425:
3252:
3172:
2951:
2330:
2066:
1970:
697:
557:
540:
302:
250:
165:
152:" because infections caused by them are difficult to treat. Such bacteria are usually sensitive only to
149:
122:
24:
5207:
4012:
3838:
3814:
3785:
3672:
3596:
3480:
3458:
2699:
1041:"Resistance Determinants and Mobile Genetic Elements of an NDM-1-Encoding Klebsiella pneumoniae Strain"
3718:
3562:
3184:
3147:
3125:
3034:
3022:
1592:
1039:
Hudson, Corey M.; Bent, Zachary W.; Meagher, Robert J.; Williams, Kelly P.; Hall, Ruth (6 June 2014).
858:
4964:
4717:
4475:
4350:
4333:
4171:
3981:
3918:
3800:
3694:
3010:
2939:
2916:
2533:
2496:
2444:
1681:
1369:
Deshpande Payal; Rodrigues Camilla; Shetty Anjali; Kapadia Farhad; Hedge Ashit; Soman Rajeev (2010).
1052:
731:
661:
620:
468:
3584:
3413:
3203:
3165:
5171:
4944:
4843:
4728:
4600:
4485:
4480:
4373:
4343:
4196:
4181:
4093:
3987:
3742:
3535:
3465:
3077:
2921:
1751:
Chen, Lei; Todd, Randall; Kiehlbauch, Julia; Walters, Maroya; Kallen, Alexander (13 January 2017).
4074:
4000:
3432:
5104:
4969:
4630:
4529:
4338:
4250:
4243:
4036:
3826:
3523:
3215:
3065:
2347:
2325:
2313:
2288:
1947:
1715:
1697:
1511:
1299:
1151:"Acquired carbapenemases in Gram-negative bacterial pathogens: detection and surveillance issues"
1021:
977:
532:
370:
1477:"Detection of Enterobacteriaceae Isolates Carrying Metallo-Beta-Lactamase — United States, 2010"
459:, which will allow the gene to be readily transferred between different strains of bacteria by
221:
layers. The carbapenems were developed to overcome antibiotic resistance mediated by bacterial
5377:
4939:
4707:
4570:
4536:
4503:
4360:
4355:
4313:
4260:
4136:
3773:
3334:
3240:
2357:
2320:
2308:
2298:
2207:
2172:
2137:
2054:
1982:
1826:
1782:
1628:
1556:
1488:
1457:
1420:
1382:
1351:
1291:
1283:
1243:
1207:
1172:
1131:
1080:
969:
961:
885:
839:
790:
528:
2776:
5150:
5145:
5119:
5047:
4422:
4298:
4233:
3992:
3750:
3705:
3658:
3496:
2662:
2272:
2197:
2162:
2127:
2044:
2034:
1816:
1772:
1764:
1689:
1620:
1546:
1449:
1341:
1333:
1275:
1235:
1199:
1162:
1121:
1113:
1070:
1060:
1011:
953:
916:
911:
863:
831:
808:
780:
772:
491:
186:
1507:
5197:
5181:
5094:
4821:
4648:
4547:
4432:
4308:
4238:
4191:
4043:
3947:
3760:
3755:
3509:
3311:
3289:
3104:
2817:
2788:
2738:
2573:
2468:
2436:
999:
713:
524:
463:. All the isolates were resistant to multiple different classes of antibiotics, including
355:
89:
19:
1476:
1685:
1440:
Muir A, Weinbren MJ (July 2010). "New Delhi metallo-beta-lactamase: a cautionary tale".
1056:
5346:
5235:
5176:
4996:
4959:
4931:
4883:
4878:
4865:
4815:
4777:
4303:
4267:
4023:
3962:
3953:
3850:
3806:
3614:
3577:
3491:
3383:
3324:
2827:
2804:
2507:
2420:
2407:
2402:
2303:
2223:
2049:
2022:
1777:
1752:
1346:
1321:
1263:
1126:
1099:
1075:
1040:
785:
760:
472:
423:
A study by a multi-national team was published in the August 2010 issue of the journal
279:
259:
255:
222:
145:
138:
2167:
2150:
2132:
1624:
1203:
835:
776:
5356:
5140:
5099:
5023:
4949:
4898:
4657:
4542:
4498:
4470:
4461:
4451:
4427:
4323:
4029:
3683:
3402:
3342:
3319:
3258:
3045:
2928:
2906:
2875:
2849:
2750:
2564:
2455:
2431:
2412:
2383:
1848:
1303:
1167:
1150:
1025:
519:
511:
233:
2116:"Extended spectrum -lactamases (ESBL) - an emerging threat to clinical therapeutics"
981:
5089:
4805:
4785:
4687:
4672:
4552:
4293:
4211:
4159:
3889:
3879:
3603:
3395:
3367:
3276:
3196:
3132:
2987:
2962:
2885:
2481:
2463:
1701:
890:
552:
148:. Bacteria that produce carbapenemases are often referred to in the news media as "
1320:
Yong D, Toleman MA, Giske CG, Cho HS, Sundman K, Lee K, Walsh TR (December 2009).
2115:
1805:"Zinc-dependent carbapenemases in clinical isolates of family Enterobacteriaceae"
1390:
1239:
1065:
317:
found that most carbapenem-resistant bacteria isolated from patients carried the
5313:
5248:
5084:
4873:
4800:
4790:
4575:
3861:
3765:
3372:
3299:
1867:"Indian Government angry over claims its hospitals are fuelling global superbug"
544:
436:
gene. This reported on 37 cases in the United Kingdom, 44 isolates with NDM-1in
359:
157:
134:
99:
5341:
1453:
5028:
4911:
4828:
4682:
4667:
4585:
4318:
3974:
3866:
3645:
3377:
3304:
2641:
2607:
2487:
2254:
957:
702:
640:
241:
214:
194:, but the gene for NDM-1 can spread from one strain of bacteria to another by
130:
65:
2103:
1287:
965:
5287:
5261:
5004:
4759:
4677:
4508:
4466:
4378:
4272:
3357:
2623:
2039:
1821:
1804:
657:
476:
297:
218:
153:
2211:
2176:
2141:
2058:
1986:
1830:
1786:
1768:
1632:
1560:
1492:
1461:
1386:
1355:
1295:
1247:
1211:
1176:
1135:
1084:
973:
843:
794:
1279:
1016:
373:
isolates bearing this newly described resistance mechanism in the US, the
258:) is currently the most common carbapenemase, which was first detected in
177:, the United Kingdom, the United States, Canada, Japan, Egypt, and Iraq.
4906:
4186:
4163:
4128:
2342:
2258:
2202:
2185:
1551:
1534:
1337:
1117:
685:
681:
480:
448:
and India. The authors' analysis of the strains showed that many carried
445:
389:
363:
351:
174:
119:
70:
4848:
4616:
4580:
4216:
2629:
677:
665:
495:
487:
456:
441:
437:
410:
396:
In July 2010, a team in New Delhi reported a cluster of three cases of
340:
332:
206:
1693:
656:, apologized and acknowledged that naming the resistance enzyme after
173:
patient of Indian origin. It was later detected in bacteria in India,
5300:
5070:
4795:
4662:
4417:
314:
237:
170:
141:
115:
384:
1149:
Miriagou V, Cornaglia G, Edelstein M, et al. (February 2010).
392:, one of the few antibiotics able to kill NDM-1 producing bacteria.
5274:
4974:
4590:
726:
429:. This examined the emergence and spread of bacteria carrying the
383:
324:
gene. Later, the journal editor apologized for allowing the name.
278:
18:
4838:
4810:
759:
Kumarasamy KK, Toleman MA, Walsh TR, et al. (August 2010).
574:
551:
In September 2016, a 70-year-old woman in Reno, Nevada, died of
523:
reported on the 16 December 2013 that a team of scientists from
5043:
4732:
4132:
2227:
2023:"Science, Names Giving and Names Calling: Change NDM-1 to PCM"
1508:"Antibiotic-Resistant Bacteria Moving From South Asia to U.S."
2104:
BBC News Health - Questions&Answers about NDM-1 superbugs
1738:"Antibiotic-resistant bacteria disarmed with fungus compound"
1647:"Antibiotic-resistant bacteria suspected in Royal Alex death"
1475:
Centers for Disease Control Prevention (CDC) (25 June 2010).
339:. The second geographical origin is considered to be eastern
409:
that were found in the intensive care unit of a hospital in
5039:
2219:
PBS Frontline Oct 22, 2013 Hunting the Nightmare Bacteria
680:
man infected while undergoing treatment in a hospital in
660:
was an "error". Following this, Ajai R. Singh, editor of
626:
In contrast, an editorial in the March 2010 issue of the
369:
As of June 2010, there were three reported cases of
1885:"Linking India to superbug unfair and wrong, says India"
1533:
Karthikeyan K, Thirunarayan MA, Krishnan P (July 2010).
668:-encoding carbapenem-resistant metallo-beta-lactamase).
502:
patient's recovery were positive for the NDM-1 enzyme.
163:
NDM-1 was first detected in 2008 in a culture plate of
5330:
1975:
The Journal of the Association of Physicians of India
998:
Al-hussaniy, Hany; Al-tameemi, Zahraa Salam (2022).
28:, the bacterium in which NDM-1 was first identified.
5226:
5190:
5159:
5128:
5077:
5013:
4990:
4925:
4892:
4859:
4771:
4629:
4609:
4561:
4450:
4441:
4393:
4286:
4224:
4210:
4170:
4066:
3940:
3741:
3626:
3613:
3356:
3288:
3230:
3157:
3057:
3044:
2980:
2899:
2868:
2861:
2766:
2606:
2554:
2395:
2382:
1998:
1996:
180:The most common bacteria that make this enzyme are
95:
85:
80:
64:
56:
44:
39:
34:
1921:"'Don't blame superbug on India, it's everywhere'"
1803:Rai, S; Singh, NP; Manchanda, V; Kaur, IR (2011).
610:for what they describe as selective malignancy. A
1419:] (in Croatian). Zagreb: Medicinska naklada.
2109:National Resistance Alert 3 addendum in UK (PDF)
1593:"Japan detects its first case of NDM-1 superbug"
1575:"First NDM-1 superbug case confirmed in Ontario"
283:Two zinc ions present in the active binding site
1798:
1796:
1100:"Carbapenemases: the versatile beta-lactamases"
859:"New drug-resistant 'superbug' arrives in Mass"
601:has disputed the conclusion of the August 2010
539:In June 2014 it was reported that the molecule
1943:"Indian author says superbug report is fudged"
1674:Environmental Science & Technology Letters
244:and inactivates these carbapenem antibiotics.
5055:
4744:
4144:
2239:
2071:: CS1 maint: DOI inactive as of March 2024 (
1716:"'Superbugs' found breeding in sewage plants"
628:Journal of Association of Physicians of India
8:
907:"Japan confirms first case of superbug gene"
754:
752:
1971:"An obituary--on the death of antibiotics!"
1757:MMWR. Morbidity and Mortality Weekly Report
379:methicillin-resistant Staphylococcus aureus
5062:
5048:
5040:
4751:
4737:
4729:
4447:
4221:
4151:
4137:
4129:
3623:
3054:
2865:
2392:
2246:
2232:
2224:
2184:Moellering, Robert C. (16 December 2010).
2087:"Belgian man dies of South Asian superbug"
1903:"'Superbug' an MNC conspiracy: BJP leader"
375:Centers for Disease Control and Prevention
77:
2201:
2166:
2131:
2048:
2038:
1820:
1776:
1550:
1345:
1166:
1125:
1074:
1064:
1015:
784:
475:, but most were still susceptible to the
1506:McNeil Jr., Donald G. (11 August 2010).
811:. Health Protection Agency. 3 July 2009.
205:
5337:
2186:"NDM-1 — A Cause for Worldwide Concern"
2004:"Lancet won't publish India's rebuttal"
1315:
1313:
748:
555:following infection with NDM-producing
381:, which are already common in the USA.
265:The resistance conferred by this gene (
129:. These include the antibiotics of the
2155:Indian Journal of Medical Microbiology
2151:"ESBL- From petri dish to the patient"
2120:Indian Journal of Medical Microbiology
2064:
1936:
1934:
1842:
1840:
1809:Indian Journal of Medical Microbiology
993:
991:
346:In May 2010, a case of infection with
327:NDM-1 β-lactamase was also found in a
31:
4980:Activation-induced cytidine deaminase
1666:
1664:
709:List of antibiotic resistant bacteria
210:Structure of the carbapenem backbone.
7:
4713:
1849:"India rejects UK 'superbug' claim"
857:Stephen Smith (13 September 2010).
444:, and 73 in various other sites in
2114:Chaudhary, U; Aggarwal, R (2004).
1941:Narayan, Pushpa (13 August 2010).
1718:. Science Daily. December 16, 2013
1004:Medical and Pharmaceutical Journal
585:Vitek detection (Automated system)
582:Double disk synergy testing (DDST)
14:
350:expressing NDM-1 was reported in
296:The NDM-1 enzyme was named after
5340:
4712:
4703:
4702:
1847:Pandey, Geeta (12 August 2010).
1168:10.1111/j.1469-0691.2009.03116.x
1098:Queenan AM, Bush K (July 2007).
946:Arab Journal of Gastroenterology
905:Shino Yuasa (8 September 2010).
684:died despite being administered
232:gene produces NDM-1, which is a
4762:: carbon-nitrogen non-peptide (
4401:Bacterial cellular morphologies
2190:New England Journal of Medicine
335:, and the patient arrived from
306:strain bearing the novel gene
4955:Inosine monophosphate synthase
1969:Abdul Ghafur, K (March 2010).
1613:The Lancet Infectious Diseases
824:The Lancet Infectious Diseases
705:, antibiotic chemical compound
426:The Lancet Infectious Diseases
1:
2168:10.1016/S0255-0857(21)02465-8
2133:10.1016/S0255-0857(21)02884-X
1625:10.1016/S1473-3099(11)70059-7
1204:10.1016/S1473-3099(09)70054-4
1105:Clinical Microbiology Reviews
836:10.1016/S1473-3099(10)70239-5
777:10.1016/S1473-3099(10)70143-2
565:Phenotypic detection of NDM-1
35:Metallo-beta-lactamase type 1
1240:10.1016/j.patbio.2009.07.026
1066:10.1371/journal.pone.0099209
648:January 2011, the editor of
1326:Antimicrob Agents Chemother
619:study, who is based in the
5399:
4917:Protein-arginine deiminase
4839:Fatty acid amide hydrolase
4644:Bacteria (classifications)
4366:Primary nutritional groups
1740:. CBC News. June 25, 2014.
1454:10.1016/j.jhin.2010.02.005
886:"Superbug detected in GTA"
809:"Health Protection Report"
608:multinational corporations
5218:Michaelis–Menten kinetics
4698:
4103:
3640:"Acidulodesulfobacteriia"
2266:
1481:MMWR Morb Mortal Wkly Rep
1413:Medicinska mikrobiologija
1268:Microbial Drug Resistance
958:10.1016/j.ajg.2019.01.002
76:
5383:Antimicrobial resistance
5110:Diffusion-limited enzyme
4520:Bacterial outer membrane
3897:"Thermodesulfovibrionia"
3635:Acidulodesulfobacteriota
2650:"Thermosediminibacteria"
2588:"Marinamargulisbacteria"
2149:Bhattacharya, S (2006).
1649:. CBC News. May 18, 2012
1599:. AFP. 6 September 2010.
1411:Kalenić, Smilja (2013).
1375:J Assoc Physicians India
593:Criticism of enzyme name
461:horizontal gene transfer
196:horizontal gene transfer
5373:Beta-lactam antibiotics
4834:Aspartylglucosaminidase
3931:Thermodesulfobacteriota
3732:"Thermosulfidibacteria"
2591:"Riflemargulisbacteria"
2043:(inactive 2024-03-06).
2040:10.4103/0973-1229.77446
2021:Singh, Ajai R. (2011).
1822:10.4103/0255-0857.83912
1155:Clin. Microbiol. Infect
737:Transduction (genetics)
465:beta-lactam antibiotics
399:Acinetobacter baumannii
127:beta-lactam antibiotics
4515:Gram-negative bacteria
4494:Gram-positive bacteria
4087:Salinosulfoleibacteria
3905:"Lambdaproteobacteria"
3727:Thermosulfidibacterota
3004:"Macinerneyibacteriia"
2647:"Thermoanaerobacteria"
2574:Vampirovibrionophyceae
1907:The New Indian Express
1769:10.15585/mmwr.mm6601a7
1539:J Antimicrob Chemother
719:Methicillin-resistant
612:Bharatiya Janata Party
599:Indian health ministry
571:metallo-beta-lactamase
393:
337:Bosnia and Herzegovina
284:
274:opposition/competition
225:enzymes. However, the
211:
29:
5203:Eadie–Hofstee diagram
5136:Allosteric regulation
4370:Substrate preference
2999:Macinerneyibacteriota
1280:10.1089/mdr.2020.0037
1017:10.55940/medphar20223
721:Staphylococcus aureus
698:Antibiotic resistance
558:Klebsiella pneumoniae
541:aspergillomarasmine A
387:
303:Klebsiella pneumoniae
282:
251:Klebsiella pneumoniae
209:
192:Klebsiella pneumoniae
166:Klebsiella pneumoniae
50:Klebsiella pneumoniae
25:Klebsiella pneumoniae
22:
5213:Lineweaver–Burk plot
4965:GTP cyclohydrolase I
4351:Microbial metabolism
3982:Polarisedimenticolia
3970:"Guanabaribacteriia"
3912:Schekmaniibacteriota
3653:"Desulfurobacteriia"
3568:"Handelsmanbacteria"
3556:"Krumholzibacteriia"
3119:Firestoneibacteriota
3099:Desantisiibacteriota
2917:Coprothermobacterota
2797:"Absconditabacteria"
2714:"Desulfitobacteriia"
2583:Margulisiibacteriota
2203:10.1056/NEJMp1011715
2027:Mens Sana Monographs
1417:Medical Microbiology
1338:10.1128/AAC.00774-09
1118:10.1128/CMR.00001-07
732:Nosocomial infection
662:Mens Sana Monographs
638:The British journal
621:University of Madras
236:beta-lactamase - an
125:to a broad range of
4945:Adenosine deaminase
4844:Histone deacetylase
4601:Non-motile bacteria
4197:Pathogenic bacteria
4116:Alternative views:
3988:Thermoanaerobaculia
3791:"Anaeroferrophilia"
3743:Deltaproteobacteria
3715:Desulfobacterota G
3578:Neomarinimicrobiota
3551:Krumholzibacteriota
3452:Edwardsiibacteriota
3178:"Hinthialibacteria"
2957:"Thermodesulfobiia"
2922:Coprothermobacteria
2734:"Halanaerobiaeota"
2682:"Thermaerobacteria"
2569:"Sericytochromatia"
1686:2014EnSTL...1...26L
1228:Pathologie Biologie
1057:2014PLoSO...999209H
486:On 21 August 2010,
5172:Enzyme superfamily
5105:Enzyme promiscuity
4970:Cytidine deaminase
4929:: Cyclic amidines/
4896:: Linear amidines/
4530:Lipopolysaccharide
3844:"Methylomirabilia"
3794:"Deferrimicrobiia"
3678:"Calescibacteriia"
3504:"Raymondbacteriia"
3486:"Fermentibacteria"
3445:Delongiibacteriota
3426:Coatesiibacteriota
3253:Lindowiibacteriota
3173:Hinthialibacterota
2952:Thermodesulfobiota
2800:"Andersenbacteria"
2726:"Syntrophomonadia"
2717:"Desulfotomaculia"
2708:"Carboxydothermia"
2539:"Eudoremicrobiia"
2524:"Heboniibacteriia"
1948:The Times of India
1552:10.1093/jac/dkq273
1512:The New York Times
394:
371:Enterobacteriaceae
285:
212:
30:
5363:Bacterial enzymes
5328:
5327:
5037:
5036:
4940:Guanine deaminase
4775:: Linear amides /
4726:
4725:
4625:
4624:
4571:Bacterial capsule
4537:Periplasmic space
4504:Lipoteichoic acid
4389:
4388:
4361:Microbial ecology
4356:Nitrogen fixation
4126:
4125:
4062:
4061:
4058:
4057:
4013:Leptospirillaeota
3967:"Fischerbacteria"
3839:Methylomirabilota
3815:Desulfuromonadota
3786:Deferrimicrobiota
3710:"Deferribacteria"
3673:Calescibacteriota
3663:"Campylobacteria"
3597:Tianyaibacteriota
3571:"Latescibacteria"
3481:Fermentibacterota
3459:Eiseniibacteriota
3361:(Sphingobacteria)
3335:Verrucomicrobiota
3293:(Planctobacteria)
3190:"Hydrogenedentia"
3092:"Tritonobacteria"
2976:
2975:
2842:"Saccharimonadia"
2823:"Howlettbacteria"
2762:
2761:
2746:"Selenobacteria"
2711:"Dehalobacteriia"
2705:"Carboxydocellia"
2700:Desulfotomaculota
2690:"Hydrogenisporia"
2679:"Symbiobacteriia"
2668:"Proteinivoracia"
2512:"Abditibacteriia"
2425:"Geothermincolia"
2196:(25): 2377–2379.
1927:. 13 August 2010.
1891:. 12 August 2010.
1873:. 14 August 2010.
1694:10.1021/ez400152e
1581:. 21 August 2010.
1545:(10): 2253–2254.
1426:978-953-176-637-1
1332:(12): 5046–5054.
1274:(10): 1133–1143.
1192:Lancet Infect Dis
894:. 22 August 2010.
765:Lancet Infect Dis
292:Origin and spread
109:
108:
105:
104:
5390:
5345:
5344:
5336:
5208:Hanes–Woolf plot
5151:Enzyme activator
5146:Enzyme inhibitor
5120:Enzyme catalysis
5064:
5057:
5050:
5041:
4863:: Cyclic amides/
4753:
4746:
4739:
4730:
4716:
4715:
4706:
4705:
4654:Former groupings
4448:
4299:Human microbiome
4222:
4153:
4146:
4139:
4130:
4018:"Leptospirillia"
3993:Vicinamibacteria
3924:"Entotheonellia"
3820:Desulfuromonadia
3751:Bdellovibrionota
3719:Syntrophorhabdia
3706:Deferribacterota
3659:Campylobacterota
3624:
3563:Latescibacterota
3497:Chitinivibrionia
3474:"Tariuqbacteria"
3347:Verrucomicrobiia
3185:Hydrogenedentota
3148:Ratteibacteriota
3141:"Velamenicoccia"
3126:Goldiibacteriota
3089:"Erginobacteria"
3083:"Ancaeobacteria"
3055:
3035:Walliibacteriota
3023:Rifleibacteriota
3016:"Muiribacteriia"
2945:"Lithacetigenia"
2866:
2836:"Microgenomatia"
2813:"Doudnabacteria"
2658:"Dethiobacteria"
2617:
2597:"Termititenacia"
2561:Cyanobacteriota
2545:"Eremiobacteria"
2476:"Limnocylindria"
2450:"Bipolaricaulia"
2393:
2295:
2275:
2248:
2241:
2234:
2225:
2215:
2205:
2180:
2170:
2145:
2135:
2091:
2090:
2083:
2077:
2076:
2070:
2062:
2052:
2042:
2018:
2012:
2011:
2010:. 13 April 2011.
2000:
1991:
1990:
1966:
1960:
1959:
1957:
1955:
1938:
1929:
1928:
1917:
1911:
1910:
1899:
1893:
1892:
1881:
1875:
1874:
1863:
1857:
1856:
1844:
1835:
1834:
1824:
1800:
1791:
1790:
1780:
1748:
1742:
1741:
1734:
1728:
1727:
1725:
1723:
1712:
1706:
1705:
1668:
1659:
1658:
1656:
1654:
1643:
1637:
1636:
1607:
1601:
1600:
1589:
1583:
1582:
1571:
1565:
1564:
1554:
1530:
1524:
1523:
1521:
1519:
1503:
1497:
1496:
1472:
1466:
1465:
1437:
1431:
1430:
1408:
1402:
1401:
1399:
1398:
1389:. Archived from
1366:
1360:
1359:
1349:
1317:
1308:
1307:
1258:
1252:
1251:
1222:
1216:
1215:
1187:
1181:
1180:
1170:
1146:
1140:
1139:
1129:
1095:
1089:
1088:
1078:
1068:
1036:
1030:
1029:
1019:
995:
986:
985:
943:
934:
928:
927:
925:
923:
917:Associated Press
912:The Boston Globe
902:
896:
895:
882:
876:
875:
873:
871:
864:The Boston Globe
854:
848:
847:
819:
813:
812:
805:
799:
798:
788:
756:
647:
588:E-test (E-Strip)
492:British Columbia
469:fluoroquinolones
187:Escherichia coli
169:isolated from a
78:
52:
32:
5398:
5397:
5393:
5392:
5391:
5389:
5388:
5387:
5353:
5352:
5351:
5339:
5331:
5329:
5324:
5236:Oxidoreductases
5222:
5198:Enzyme kinetics
5186:
5182:List of enzymes
5155:
5124:
5095:Catalytic triad
5073:
5068:
5038:
5033:
5009:
4997:Aminohydrolases
4995:
4986:
4932:Aminohydrolases
4930:
4921:
4897:
4888:
4866:Amidohydrolases
4864:
4855:
4778:Amidohydrolases
4776:
4767:
4757:
4727:
4722:
4694:
4649:Bacterial phyla
4633:
4621:
4605:
4563:
4557:
4548:Arabinogalactan
4453:
4437:
4385:
4282:
4226:
4214:
4206:
4192:Lysogenic cycle
4173:
4166:
4157:
4127:
4122:
4110:Bergey's Manual
4099:
4054:
4049:"Pseudomonadia"
3959:"Aminicenantia"
3948:Acidobacteriota
3936:
3919:Tectimicrobiota
3801:Deferrisomatota
3761:Bdellovibrionia
3756:Bacteriovoracia
3737:
3695:Dadaibacteriota
3617:
3609:
3604:Zixiibacteriota
3590:"Marinisomatia"
3544:"Stahlbacteria"
3517:"Glassbacteria"
3510:Gemmatimonadota
3419:"Cloacimonadia"
3384:Ignavibacteriia
3360:
3352:
3339:Kiritimatiellia
3329:"Uabimicrobiia"
3312:Planctomycetota
3292:
3284:
3233:bacteriobiontes
3232:
3226:
3209:"Saltatorellae"
3153:
3105:Elusimicrobiota
3048:
3040:
3028:"Ozemibacteria"
3011:Muiribacteriota
2972:
2940:Lithacetigenota
2929:Dictyoglomerota
2895:
2857:
2845:"Torokbacteria"
2839:"Paceibacteria"
2833:"Kazanbacteria"
2818:Gracilibacteria
2810:"Dojkabacteria"
2789:Patescibacteria
2782:"Elulimicrobia"
2758:
2676:"Sulfobacillia"
2615:
2614:
2610:
2602:
2594:"Saganbacteria"
2555:Cyanoprokaryota
2550:
2534:Eremiobacterota
2502:"Dormibacteria"
2497:Dormiibacterota
2473:Ktedonobacteria
2469:Dehalococcoidia
2445:Bipolaricaulota
2437:Thermoleophilia
2428:"Humimicrobiia"
2386:
2378:
2377:
2293:
2271:
2262:
2252:
2183:
2148:
2113:
2100:
2095:
2094:
2085:
2084:
2080:
2063:
2020:
2019:
2015:
2002:
2001:
1994:
1968:
1967:
1963:
1953:
1951:
1940:
1939:
1932:
1925:Hindustan Times
1919:
1918:
1914:
1901:
1900:
1896:
1889:Hindustan Times
1883:
1882:
1878:
1865:
1864:
1860:
1846:
1845:
1838:
1802:
1801:
1794:
1750:
1749:
1745:
1736:
1735:
1731:
1721:
1719:
1714:
1713:
1709:
1670:
1669:
1662:
1652:
1650:
1645:
1644:
1640:
1609:
1608:
1604:
1591:
1590:
1586:
1573:
1572:
1568:
1532:
1531:
1527:
1517:
1515:
1505:
1504:
1500:
1474:
1473:
1469:
1442:J. Hosp. Infect
1439:
1438:
1434:
1427:
1410:
1409:
1405:
1396:
1394:
1368:
1367:
1363:
1319:
1318:
1311:
1260:
1259:
1255:
1224:
1223:
1219:
1189:
1188:
1184:
1148:
1147:
1143:
1097:
1096:
1092:
1038:
1037:
1033:
997:
996:
989:
941:
936:
935:
931:
921:
919:
904:
903:
899:
884:
883:
879:
869:
867:
856:
855:
851:
830:(11): 749–750.
821:
820:
816:
807:
806:
802:
758:
757:
750:
745:
714:Medical tourism
694:
674:
645:
595:
567:
473:aminoglycosides
453:
434:
418:
407:
322:
311:
294:
270:
254:carbapenemase (
230:
204:
202:Enzyme function
48:
17:
12:
11:
5:
5396:
5394:
5386:
5385:
5380:
5375:
5370:
5365:
5355:
5354:
5350:
5349:
5326:
5325:
5323:
5322:
5309:
5296:
5283:
5270:
5257:
5244:
5230:
5228:
5224:
5223:
5221:
5220:
5215:
5210:
5205:
5200:
5194:
5192:
5188:
5187:
5185:
5184:
5179:
5174:
5169:
5163:
5161:
5160:Classification
5157:
5156:
5154:
5153:
5148:
5143:
5138:
5132:
5130:
5126:
5125:
5123:
5122:
5117:
5112:
5107:
5102:
5097:
5092:
5087:
5081:
5079:
5075:
5074:
5069:
5067:
5066:
5059:
5052:
5044:
5035:
5034:
5032:
5031:
5026:
5020:
5018:
5011:
5010:
5008:
5007:
5001:
4999:
4988:
4987:
4985:
4984:
4983:
4982:
4977:
4967:
4962:
4960:DCMP deaminase
4957:
4952:
4947:
4942:
4936:
4934:
4923:
4922:
4920:
4919:
4914:
4909:
4903:
4901:
4899:Ureohydrolases
4890:
4889:
4887:
4886:
4884:Dihydroorotase
4881:
4879:Beta-lactamase
4876:
4870:
4868:
4857:
4856:
4854:
4853:
4852:
4851:
4841:
4836:
4831:
4826:
4825:
4824:
4819:
4816:Aspartoacylase
4813:
4803:
4798:
4793:
4788:
4782:
4780:
4769:
4768:
4758:
4756:
4755:
4748:
4741:
4733:
4724:
4723:
4721:
4720:
4710:
4699:
4696:
4695:
4693:
4692:
4691:
4690:
4685:
4680:
4675:
4665:
4660:
4651:
4646:
4640:
4638:
4627:
4626:
4623:
4622:
4620:
4619:
4613:
4611:
4607:
4606:
4604:
4603:
4598:
4593:
4588:
4583:
4578:
4573:
4567:
4565:
4559:
4558:
4556:
4555:
4550:
4539:
4534:
4533:
4532:
4527:
4511:
4506:
4501:
4490:
4489:
4488:
4483:
4478:
4464:
4458:
4456:
4445:
4439:
4438:
4436:
4435:
4430:
4425:
4420:
4415:
4414:
4413:
4408:
4406:cell structure
4397:
4395:
4391:
4390:
4387:
4386:
4384:
4383:
4382:
4381:
4379:Saccharophilic
4376:
4368:
4363:
4358:
4353:
4348:
4347:
4346:
4341:
4336:
4331:
4321:
4316:
4311:
4306:
4296:
4290:
4288:
4284:
4283:
4281:
4280:
4275:
4270:
4268:Microaerophile
4265:
4264:
4263:
4258:
4248:
4247:
4246:
4241:
4230:
4228:
4219:
4208:
4207:
4205:
4204:
4199:
4194:
4189:
4184:
4178:
4176:
4168:
4167:
4158:
4156:
4155:
4148:
4141:
4133:
4124:
4123:
4121:
4120:
4114:
4104:
4101:
4100:
4098:
4097:
4090:
4083:
4082:
4081:
4070:
4068:
4064:
4063:
4060:
4059:
4056:
4055:
4053:
4052:
4051:
4050:
4047:
4040:
4033:
4024:Pseudomonadota
4021:
4020:
4019:
4009:
4008:
4007:
3997:
3996:
3995:
3990:
3985:
3978:
3971:
3968:
3965:
3963:Blastocatellia
3960:
3957:
3954:Acidobacteriia
3944:
3942:
3938:
3937:
3935:
3934:
3927:
3926:
3925:
3915:
3908:
3907:
3906:
3900:
3899:
3898:
3895:
3887:
3886:
3885:
3877:
3876:
3875:
3872:
3871:"Bradymonadia"
3869:
3859:
3858:
3857:
3856:"Moduliflexia"
3847:
3846:
3845:
3835:
3834:
3833:
3823:
3822:
3821:
3811:
3810:
3809:
3807:Deferrisomatia
3797:
3796:
3795:
3792:
3782:
3781:
3780:
3770:
3769:
3768:
3763:
3758:
3747:
3745:
3739:
3738:
3736:
3735:
3734:
3733:
3723:
3722:
3721:
3713:
3712:
3711:
3703:
3702:
3701:
3700:"Dadabacteria"
3691:
3690:
3689:
3681:
3680:
3679:
3669:
3668:
3667:
3664:
3656:
3655:
3654:
3651:
3643:
3642:
3641:
3630:
3628:
3621:
3615:Proteobacteria
3611:
3610:
3608:
3607:
3600:
3593:
3592:
3591:
3585:Marinisomatota
3581:
3574:
3573:
3572:
3569:
3559:
3558:
3557:
3547:
3546:
3545:
3542:
3541:"Hydrothermia"
3532:
3531:
3530:
3520:
3519:
3518:
3515:
3514:Gemmatimonadia
3507:
3506:
3505:
3502:
3499:
3492:Fibrobacterota
3489:
3488:
3487:
3477:
3476:
3475:
3472:
3471:"Electryoneia"
3462:
3455:
3448:
3441:
3440:
3439:
3438:"Cosmopolitia"
3429:
3422:
3421:
3420:
3414:Cloacimonadota
3410:
3409:
3408:
3400:
3399:
3398:
3393:
3390:
3389:"Kapabacteria"
3387:
3380:
3375:
3364:
3362:
3354:
3353:
3351:
3350:
3349:
3348:
3345:
3340:
3332:
3331:
3330:
3327:
3325:Planctomycetia
3322:
3317:
3309:
3308:
3307:
3296:
3294:
3286:
3285:
3283:
3282:
3281:
3280:
3273:
3270:
3267:
3266:"Brachyspirae"
3264:
3263:"Brevinematia"
3256:
3249:
3248:
3247:
3236:
3234:
3228:
3227:
3225:
3224:
3223:
3222:
3212:
3211:
3210:
3204:Saltatorellota
3200:
3197:Poribacteriota
3193:
3192:
3191:
3181:
3180:
3179:
3169:
3166:Abyssubacteria
3161:
3159:
3155:
3154:
3152:
3151:
3144:
3143:
3142:
3139:
3129:
3122:
3115:
3114:
3113:
3110:
3109:Elusimicrobiia
3102:
3095:
3094:
3093:
3090:
3087:
3086:"Auribacteria"
3084:
3074:
3073:
3072:
3061:
3059:
3052:
3042:
3041:
3039:
3038:
3031:
3030:
3029:
3019:
3018:
3017:
3007:
3006:
3005:
2995:
2994:
2993:
2988:Fusobacteriota
2984:
2982:
2978:
2977:
2974:
2973:
2971:
2970:
2969:
2968:
2960:
2959:
2958:
2948:
2947:
2946:
2936:
2935:
2934:
2933:Dictyoglomeria
2926:
2925:
2924:
2914:
2913:
2912:
2903:
2901:
2897:
2896:
2894:
2893:
2892:
2891:
2883:
2882:
2881:
2872:
2870:
2863:
2859:
2858:
2856:
2855:
2854:
2853:
2846:
2843:
2840:
2837:
2834:
2831:
2828:Katanobacteria
2824:
2821:
2814:
2811:
2808:
2805:Berkelbacteria
2801:
2798:
2795:
2785:
2784:
2783:
2772:
2770:
2764:
2763:
2760:
2759:
2757:
2756:
2755:
2754:
2744:
2743:
2742:
2732:
2731:
2730:
2729:"Thermincolia"
2727:
2724:
2721:
2718:
2715:
2712:
2709:
2706:
2696:
2695:
2694:
2691:
2685:
2684:
2683:
2680:
2677:
2671:
2670:
2669:
2666:
2663:Natranaerobiia
2659:
2653:
2652:
2651:
2648:
2645:
2635:
2634:
2633:
2620:
2618:
2604:
2603:
2601:
2600:
2599:
2598:
2595:
2592:
2589:
2579:
2578:
2577:
2570:
2567:
2558:
2556:
2552:
2551:
2549:
2548:
2547:
2546:
2543:
2537:
2530:
2529:
2528:
2525:
2522:
2521:Fimbriimonadia
2519:
2518:Chthonomonadia
2516:
2513:
2508:Armatimonadota
2505:
2504:
2503:
2493:
2492:
2491:
2479:
2478:
2477:
2474:
2471:
2466:
2461:
2453:
2452:
2451:
2441:
2440:
2439:
2434:
2429:
2426:
2423:
2421:Coriobacteriia
2418:
2417:"Aquicultoria"
2415:
2410:
2408:Acidimicrobiia
2403:Actinomycetota
2399:
2397:
2390:
2380:
2379:
2376:
2375:
2374:
2373:
2372:
2371:
2368:Mesomycetozoea
2365:
2360:
2350:
2340:
2339:
2338:
2333:
2328:
2323:
2318:
2317:
2316:
2304:Diaphoretickes
2301:
2296:
2291:
2286:
2281:
2276:
2268:
2267:
2264:
2263:
2261:classification
2253:
2251:
2250:
2243:
2236:
2228:
2222:
2221:
2216:
2181:
2146:
2111:
2106:
2099:
2098:External links
2096:
2093:
2092:
2078:
2033:(1): 294–319.
2013:
1992:
1961:
1930:
1912:
1909:. 16 May 2012.
1894:
1876:
1858:
1836:
1792:
1743:
1729:
1707:
1660:
1638:
1619:(5): 355–362.
1602:
1597:Medical Xpress
1584:
1566:
1525:
1498:
1467:
1448:(3): 239–240.
1432:
1425:
1403:
1361:
1309:
1253:
1217:
1198:(4): 228–236.
1182:
1161:(2): 112–122.
1141:
1112:(3): 440–458.
1090:
1031:
987:
929:
897:
877:
849:
814:
800:
771:(9): 597–602.
747:
746:
744:
741:
740:
739:
734:
729:
724:
716:
711:
706:
700:
693:
690:
673:
670:
654:Richard Horton
633:Times of India
594:
591:
590:
589:
586:
583:
566:
563:
451:
432:
416:
405:
320:
309:
293:
290:
268:
260:North Carolina
228:
223:beta-lactamase
203:
200:
146:carbapenemases
139:beta-lactamase
107:
106:
103:
102:
97:
93:
92:
87:
83:
82:
74:
73:
68:
62:
61:
58:
54:
53:
46:
42:
41:
37:
36:
15:
13:
10:
9:
6:
4:
3:
2:
5395:
5384:
5381:
5379:
5376:
5374:
5371:
5369:
5366:
5364:
5361:
5360:
5358:
5348:
5343:
5338:
5334:
5320:
5316:
5315:
5310:
5307:
5303:
5302:
5297:
5294:
5290:
5289:
5284:
5281:
5277:
5276:
5271:
5268:
5264:
5263:
5258:
5255:
5251:
5250:
5245:
5242:
5238:
5237:
5232:
5231:
5229:
5225:
5219:
5216:
5214:
5211:
5209:
5206:
5204:
5201:
5199:
5196:
5195:
5193:
5189:
5183:
5180:
5178:
5177:Enzyme family
5175:
5173:
5170:
5168:
5165:
5164:
5162:
5158:
5152:
5149:
5147:
5144:
5142:
5141:Cooperativity
5139:
5137:
5134:
5133:
5131:
5127:
5121:
5118:
5116:
5113:
5111:
5108:
5106:
5103:
5101:
5100:Oxyanion hole
5098:
5096:
5093:
5091:
5088:
5086:
5083:
5082:
5080:
5076:
5072:
5065:
5060:
5058:
5053:
5051:
5046:
5045:
5042:
5030:
5029:Thiaminase II
5027:
5025:
5024:Riboflavinase
5022:
5021:
5019:
5016:
5012:
5006:
5003:
5002:
5000:
4998:
4993:
4989:
4981:
4978:
4976:
4973:
4972:
4971:
4968:
4966:
4963:
4961:
4958:
4956:
4953:
4951:
4950:AMP deaminase
4948:
4946:
4943:
4941:
4938:
4937:
4935:
4933:
4928:
4924:
4918:
4915:
4913:
4910:
4908:
4905:
4904:
4902:
4900:
4895:
4891:
4885:
4882:
4880:
4877:
4875:
4872:
4871:
4869:
4867:
4862:
4858:
4850:
4847:
4846:
4845:
4842:
4840:
4837:
4835:
4832:
4830:
4827:
4823:
4820:
4817:
4814:
4812:
4809:
4808:
4807:
4804:
4802:
4799:
4797:
4794:
4792:
4789:
4787:
4784:
4783:
4781:
4779:
4774:
4770:
4765:
4761:
4754:
4749:
4747:
4742:
4740:
4735:
4734:
4731:
4719:
4711:
4709:
4701:
4700:
4697:
4689:
4686:
4684:
4681:
4679:
4676:
4674:
4671:
4670:
4669:
4666:
4664:
4661:
4659:
4658:Schizomycetes
4655:
4652:
4650:
4647:
4645:
4642:
4641:
4639:
4637:
4632:
4628:
4618:
4615:
4614:
4612:
4608:
4602:
4599:
4597:
4594:
4592:
4589:
4587:
4584:
4582:
4579:
4577:
4574:
4572:
4569:
4568:
4566:
4560:
4554:
4551:
4549:
4546:
4544:
4540:
4538:
4535:
4531:
4528:
4526:
4523:
4522:
4521:
4518:
4516:
4512:
4510:
4507:
4505:
4502:
4500:
4499:Teichoic acid
4497:
4495:
4491:
4487:
4484:
4482:
4479:
4477:
4474:
4473:
4472:
4471:Peptidoglycan
4468:
4465:
4463:
4462:Cell membrane
4460:
4459:
4457:
4455:
4449:
4446:
4444:
4440:
4434:
4431:
4429:
4426:
4424:
4421:
4419:
4416:
4412:
4409:
4407:
4404:
4403:
4402:
4399:
4398:
4396:
4392:
4380:
4377:
4375:
4372:
4371:
4369:
4367:
4364:
4362:
4359:
4357:
4354:
4352:
4349:
4345:
4342:
4340:
4337:
4335:
4332:
4329:
4325:
4322:
4320:
4317:
4315:
4312:
4310:
4307:
4305:
4302:
4301:
4300:
4297:
4295:
4292:
4291:
4289:
4285:
4279:
4276:
4274:
4271:
4269:
4266:
4262:
4259:
4257:
4254:
4253:
4252:
4249:
4245:
4242:
4240:
4237:
4236:
4235:
4232:
4231:
4229:
4223:
4220:
4218:
4213:
4209:
4203:
4200:
4198:
4195:
4193:
4190:
4188:
4185:
4183:
4180:
4179:
4177:
4175:
4169:
4165:
4161:
4154:
4149:
4147:
4142:
4140:
4135:
4134:
4131:
4119:
4115:
4112:
4111:
4106:
4105:
4102:
4095:
4094:Teskebacteria
4091:
4088:
4084:
4080:"Qinglongiia"
4079:
4078:
4076:
4072:
4071:
4069:
4065:
4048:
4045:
4044:Magnetococcia
4041:
4038:
4037:Mariprofundia
4034:
4031:
4030:Caulobacteria
4027:
4026:
4025:
4022:
4017:
4016:
4014:
4010:
4006:"Canglongiia"
4005:
4004:
4002:
3998:
3994:
3991:
3989:
3986:
3983:
3979:
3976:
3972:
3969:
3966:
3964:
3961:
3958:
3955:
3951:
3950:
3949:
3946:
3945:
3943:
3939:
3932:
3928:
3923:
3922:
3920:
3916:
3913:
3909:
3904:
3903:
3901:
3896:
3893:
3892:
3891:
3888:
3883:
3882:
3881:
3878:
3873:
3870:
3868:
3865:
3864:
3863:
3860:
3855:
3854:
3852:
3851:Moduliflexota
3848:
3843:
3842:
3840:
3836:
3831:
3830:
3828:
3824:
3819:
3818:
3816:
3812:
3808:
3805:
3804:
3802:
3798:
3793:
3790:
3789:
3787:
3783:
3778:
3777:
3775:
3771:
3767:
3764:
3762:
3759:
3757:
3754:
3753:
3752:
3749:
3748:
3746:
3744:
3740:
3731:
3730:
3728:
3724:
3720:
3717:
3716:
3714:
3709:
3708:
3707:
3704:
3699:
3698:
3696:
3692:
3687:
3686:
3685:
3684:Chrysiogenota
3682:
3677:
3676:
3674:
3670:
3666:Desulfurellia
3665:
3662:
3661:
3660:
3657:
3652:
3649:
3648:
3647:
3644:
3639:
3638:
3636:
3632:
3631:
3629:
3625:
3622:
3620:
3616:
3612:
3605:
3601:
3598:
3594:
3589:
3588:
3586:
3582:
3579:
3575:
3570:
3567:
3566:
3564:
3560:
3555:
3554:
3552:
3548:
3543:
3540:
3539:
3537:
3536:Hydrothermota
3533:
3528:
3527:
3525:
3521:
3516:
3513:
3512:
3511:
3508:
3503:
3501:Fibrobacteria
3500:
3498:
3495:
3494:
3493:
3490:
3485:
3484:
3482:
3478:
3473:
3470:
3469:
3467:
3466:Electryoneota
3463:
3460:
3456:
3453:
3449:
3446:
3442:
3437:
3436:
3434:
3430:
3427:
3423:
3418:
3417:
3415:
3411:
3406:
3405:
3404:
3403:Calditrichota
3401:
3397:
3394:
3391:
3388:
3385:
3381:
3379:
3376:
3374:
3371:
3370:
3369:
3366:
3365:
3363:
3359:
3355:
3346:
3344:
3343:Lentisphaeria
3341:
3338:
3337:
3336:
3333:
3328:
3326:
3323:
3321:
3320:Phycisphaeria
3318:
3315:
3314:
3313:
3310:
3306:
3303:
3302:
3301:
3298:
3297:
3295:
3291:
3287:
3278:
3274:
3272:"Leptospiria"
3271:
3269:"Exilispiria"
3268:
3265:
3262:
3261:
3260:
3259:Spirochaetota
3257:
3254:
3250:
3245:
3244:
3242:
3238:
3237:
3235:
3229:
3220:
3219:
3217:
3213:
3208:
3207:
3205:
3201:
3198:
3194:
3189:
3188:
3186:
3182:
3177:
3176:
3174:
3170:
3167:
3163:
3162:
3160:
3156:
3149:
3145:
3140:
3138:"Omnitrophia"
3137:
3136:
3134:
3130:
3127:
3123:
3120:
3116:
3112:Endomicrobiia
3111:
3108:
3107:
3106:
3103:
3100:
3096:
3091:
3088:
3085:
3082:
3081:
3079:
3078:Auribacterota
3075:
3070:
3069:
3067:
3063:
3062:
3060:
3056:
3053:
3051:
3047:
3046:Hydrobacteria
3043:
3036:
3032:
3027:
3026:
3024:
3020:
3015:
3014:
3012:
3008:
3003:
3002:
3000:
2996:
2992:Fusobacteriia
2991:
2990:
2989:
2986:
2985:
2983:
2981:Fusobacterida
2979:
2967:"Thermotogia"
2966:
2965:
2964:
2961:
2956:
2955:
2953:
2949:
2944:
2943:
2941:
2937:
2932:
2931:
2930:
2927:
2923:
2920:
2919:
2918:
2915:
2910:
2909:
2908:
2907:Caldisericota
2905:
2904:
2902:
2898:
2889:
2888:
2887:
2884:
2879:
2878:
2877:
2876:Atribacterota
2874:
2873:
2871:
2869:Synergistetes
2867:
2864:
2860:
2851:
2850:Wirthbacteria
2847:
2844:
2841:
2838:
2835:
2832:
2829:
2825:
2822:
2819:
2815:
2812:
2809:
2806:
2802:
2799:
2796:
2793:
2792:
2790:
2786:
2781:
2780:
2778:
2774:
2773:
2771:
2769:
2765:
2752:
2751:Selenomonadia
2748:
2747:
2745:
2740:
2739:Halanaerobiia
2736:
2735:
2733:
2728:
2725:
2723:"Peptococcia"
2722:
2719:
2716:
2713:
2710:
2707:
2704:
2703:
2701:
2697:
2692:
2689:
2688:
2686:
2681:
2678:
2675:
2674:
2672:
2667:
2664:
2660:
2657:
2656:
2654:
2649:
2646:
2643:
2639:
2638:
2636:
2631:
2627:
2626:
2625:
2622:
2621:
2619:
2613:
2609:
2605:
2596:
2593:
2590:
2587:
2586:
2584:
2580:
2575:
2571:
2568:
2566:
2565:Cyanobacteria
2563:
2562:
2560:
2559:
2557:
2553:
2544:
2541:
2540:
2538:
2535:
2531:
2526:
2523:
2520:
2517:
2515:Armatimonadia
2514:
2511:
2510:
2509:
2506:
2501:
2500:
2498:
2494:
2489:
2485:
2484:
2483:
2480:
2475:
2472:
2470:
2467:
2465:
2462:
2460:"Caldilineia"
2459:
2458:
2457:
2456:Chloroflexota
2454:
2449:
2448:
2446:
2442:
2438:
2435:
2433:
2432:Rubrobacteria
2430:
2427:
2424:
2422:
2419:
2416:
2414:
2413:Actinomycetia
2411:
2409:
2406:
2405:
2404:
2401:
2400:
2398:
2394:
2391:
2389:
2388:BV1, BV3, BV5
2385:
2384:Terrabacteria
2381:
2369:
2366:
2364:
2361:
2359:
2356:
2355:
2354:
2351:
2349:
2346:
2345:
2344:
2341:
2337:
2334:
2332:
2331:Stramenopiles
2329:
2327:
2324:
2322:
2319:
2315:
2312:
2311:
2310:
2307:
2306:
2305:
2302:
2300:
2297:
2294:(major groups
2292:
2290:
2287:
2285:
2282:
2280:
2277:
2274:
2270:
2269:
2265:
2260:
2256:
2249:
2244:
2242:
2237:
2235:
2230:
2229:
2226:
2220:
2217:
2213:
2209:
2204:
2199:
2195:
2191:
2187:
2182:
2178:
2174:
2169:
2164:
2160:
2156:
2152:
2147:
2143:
2139:
2134:
2129:
2125:
2121:
2117:
2112:
2110:
2107:
2105:
2102:
2101:
2097:
2089:. 2010-08-13.
2088:
2082:
2079:
2074:
2068:
2060:
2056:
2051:
2046:
2041:
2036:
2032:
2028:
2024:
2017:
2014:
2009:
2005:
1999:
1997:
1993:
1988:
1984:
1980:
1976:
1972:
1965:
1962:
1950:
1949:
1944:
1937:
1935:
1931:
1926:
1922:
1916:
1913:
1908:
1904:
1898:
1895:
1890:
1886:
1880:
1877:
1872:
1871:The Telegraph
1868:
1862:
1859:
1854:
1850:
1843:
1841:
1837:
1832:
1828:
1823:
1818:
1814:
1810:
1806:
1799:
1797:
1793:
1788:
1784:
1779:
1774:
1770:
1766:
1762:
1758:
1754:
1747:
1744:
1739:
1733:
1730:
1717:
1711:
1708:
1703:
1699:
1695:
1691:
1687:
1683:
1679:
1675:
1667:
1665:
1661:
1648:
1642:
1639:
1634:
1630:
1626:
1622:
1618:
1614:
1606:
1603:
1598:
1594:
1588:
1585:
1580:
1576:
1570:
1567:
1562:
1558:
1553:
1548:
1544:
1540:
1536:
1529:
1526:
1514:
1513:
1509:
1502:
1499:
1494:
1490:
1486:
1482:
1478:
1471:
1468:
1463:
1459:
1455:
1451:
1447:
1443:
1436:
1433:
1428:
1422:
1418:
1414:
1407:
1404:
1393:on 2010-08-26
1392:
1388:
1384:
1380:
1376:
1372:
1365:
1362:
1357:
1353:
1348:
1343:
1339:
1335:
1331:
1327:
1323:
1316:
1314:
1310:
1305:
1301:
1297:
1293:
1289:
1285:
1281:
1277:
1273:
1269:
1265:
1257:
1254:
1249:
1245:
1241:
1237:
1233:
1230:(in French).
1229:
1221:
1218:
1213:
1209:
1205:
1201:
1197:
1193:
1186:
1183:
1178:
1174:
1169:
1164:
1160:
1156:
1152:
1145:
1142:
1137:
1133:
1128:
1123:
1119:
1115:
1111:
1107:
1106:
1101:
1094:
1091:
1086:
1082:
1077:
1072:
1067:
1062:
1058:
1054:
1051:(6): e99209.
1050:
1046:
1042:
1035:
1032:
1027:
1023:
1018:
1013:
1009:
1005:
1001:
994:
992:
988:
983:
979:
975:
971:
967:
963:
959:
955:
951:
947:
940:
933:
930:
918:
914:
913:
908:
901:
898:
893:
892:
887:
881:
878:
866:
865:
860:
853:
850:
845:
841:
837:
833:
829:
825:
818:
815:
810:
804:
801:
796:
792:
787:
782:
778:
774:
770:
766:
762:
755:
753:
749:
742:
738:
735:
733:
730:
728:
725:
723:
722:
717:
715:
712:
710:
707:
704:
701:
699:
696:
695:
691:
689:
687:
683:
679:
671:
669:
667:
663:
659:
655:
651:
643:
642:
636:
634:
629:
624:
622:
618:
613:
609:
604:
600:
592:
587:
584:
581:
580:
579:
576:
572:
564:
562:
560:
559:
554:
549:
546:
542:
537:
534:
530:
526:
522:
521:
520:Science Daily
516:
514:
513:
512:Acinetobacter
507:
503:
499:
497:
493:
489:
484:
482:
478:
474:
470:
466:
462:
458:
454:
447:
443:
439:
435:
428:
427:
421:
419:
412:
408:
401:
400:
391:
388:Structure of
386:
382:
380:
376:
372:
367:
365:
361:
357:
353:
349:
344:
342:
338:
334:
331:isolate from
330:
329:K. pneumoniae
325:
323:
316:
312:
305:
304:
299:
291:
289:
281:
277:
275:
271:
263:
261:
257:
253:
252:
245:
243:
239:
235:
234:carbapenemase
231:
224:
220:
216:
208:
201:
199:
197:
193:
189:
188:
183:
182:gram-negative
178:
176:
172:
168:
167:
161:
159:
155:
151:
147:
143:
140:
137:that encodes
136:
132:
128:
124:
121:
117:
113:
101:
98:
94:
91:
88:
84:
79:
75:
72:
69:
67:
63:
59:
55:
51:
47:
43:
38:
33:
27:
26:
21:
5368:Bacteriology
5314:Translocases
5311:
5298:
5285:
5272:
5259:
5249:Transferases
5246:
5233:
5090:Binding site
4806:Aminoacylase
4786:Asparaginase
4688:Mendosicutes
4673:Gracilicutes
4653:
4553:Mycolic acid
4543:Mycobacteria
4541:
4513:
4492:
4428:Coccobacilli
4328:in pregnancy
4294:Extremophile
4278:Aerotolerant
4212:Biochemistry
4174:microbiology
4160:Microbiology
4108:
4075:Qinglongiota
4001:Canglongiota
3890:Nitrospirota
3880:Nitrospinota
3832:"Lernaellia"
3688:Chrysiogenia
3529:"Heilongiia"
3433:Cosmopoliota
3407:Calditrichia
3396:Rhodothermia
3392:"Kryptoniia"
3368:Bacteroidota
3277:Spirochaetia
3221:"Sumerlaeia"
3133:Omnitrophota
3071:"Aerophobia"
2963:Thermotogota
2911:Caldisericia
2886:Synergistota
2880:Atribacteria
2862:Thermotogida
2693:Limnochordia
2687:Bacillota G
2673:Bacillota E
2655:Bacillota D
2637:Bacillota A
2527:"Zipacnadia"
2482:Deinococcota
2464:Chloroflexia
2353:Opisthokonta
2193:
2189:
2158:
2154:
2126:(2): 75–80.
2123:
2119:
2081:
2067:cite journal
2030:
2026:
2016:
2007:
1978:
1974:
1964:
1952:. Retrieved
1946:
1924:
1915:
1906:
1897:
1888:
1879:
1870:
1861:
1852:
1815:(3): 275–9.
1812:
1808:
1760:
1756:
1746:
1732:
1720:. Retrieved
1710:
1680:(1): 26–30.
1677:
1673:
1651:. Retrieved
1641:
1616:
1612:
1605:
1596:
1587:
1578:
1569:
1542:
1538:
1528:
1516:. Retrieved
1510:
1501:
1484:
1480:
1470:
1445:
1441:
1435:
1416:
1412:
1406:
1395:. Retrieved
1391:the original
1378:
1374:
1364:
1329:
1325:
1271:
1267:
1256:
1234:(1): 39–45.
1231:
1227:
1220:
1195:
1191:
1185:
1158:
1154:
1144:
1109:
1103:
1093:
1048:
1044:
1034:
1010:(1): 14–24.
1007:
1003:
952:(1): 19–22.
949:
945:
932:
920:. Retrieved
910:
900:
891:Toronto Star
889:
880:
870:18 September
868:. Retrieved
862:
852:
827:
823:
817:
803:
768:
764:
720:
675:
649:
639:
637:
632:
627:
625:
616:
602:
596:
568:
556:
553:septic shock
550:
538:
518:
517:
510:
508:
504:
500:
485:
449:
430:
424:
422:
414:
403:
397:
395:
368:
347:
345:
328:
326:
318:
307:
301:
295:
286:
266:
264:
249:
246:
226:
213:
191:
185:
179:
164:
162:
111:
110:
23:
5085:Active site
4994:: Nitriles/
4874:Barbiturase
4801:Biotinidase
4791:Glutaminase
4576:Slime layer
4256:Facultative
4244:Facultative
4118:Wikispecies
4113:(2001–2012)
3894:Nitrospiria
3884:Nitrospinia
3862:Myxococcota
3827:Lernaellota
3766:Oligoflexia
3524:Heilongiota
3373:Bacteroidia
3316:"Brocadiia"
3300:Chlamydiota
3231:Spirochaeto
3216:Sumerlaeota
3066:Aerophobota
2900:Thermocalda
2890:Synergistia
2720:"Moorellia"
2642:Clostridiia
2488:Deinococcia
2255:Prokaryotes
2161:(1): 20–4.
1487:(24): 750.
1381:: 147–150.
922:14 February
545:Aspergillus
479:antibiotic
360:tigecycline
215:Carbapenems
158:tigecycline
135:gene family
118:that makes
90:Swiss-model
40:Identifiers
5357:Categories
5288:Isomerases
5262:Hydrolases
5129:Regulation
4912:Agmatinase
4829:Ceramidase
4760:Hydrolases
4683:Mollicutes
4678:Firmicutes
4668:Prokaryota
4586:Glycocalyx
4411:plasticity
4374:Lipophilic
4227:preference
4202:Resistance
3975:Holophagia
3874:Polyangiia
3867:Myxococcia
3646:Aquificota
3627:Aquificida
3378:Chlorobiia
3305:Chlamydiia
3246:"Babeliae"
2608:Firmicutes
2542:"Xenobiia"
1722:22 January
1653:22 January
1397:2010-08-13
743:References
703:GSK 299423
650:The Lancet
641:The Lancet
242:hydrolyzes
154:polymyxins
131:carbapenem
86:Structures
81:Search for
5167:EC number
5005:Nitrilase
4636:evolution
4610:Composite
4509:Endospore
4467:Cell wall
4443:Structure
4334:Placental
4273:Nanaerobe
4251:Anaerobic
4182:Infection
3779:"Binatia"
3650:Aquificia
3358:FCB group
3290:PVC group
2768:CPR group
2624:Bacillota
2348:Amoebozoa
2326:Alveolata
2314:Cryptista
2289:Eukaryota
2008:The Hindu
1981:: 143–4.
1954:13 August
1763:(1): 33.
1518:13 August
1304:218504647
1288:1076-6294
1026:249296879
966:1687-1979
658:New Delhi
543:from the
477:polymyxin
298:New Delhi
219:cell wall
150:superbugs
123:resistant
5378:EC 3.5.2
5191:Kinetics
5115:Cofactor
5078:Activity
4907:Arginase
4708:Category
4631:Taxonomy
4564:envelope
4454:envelope
4344:Salivary
4261:Obligate
4239:Obligate
4187:Exotoxin
4164:Bacteria
4107:Source:
3774:Binatota
3241:Babelota
3050:BV2, BV4
2630:Bacillia
2343:Amorphea
2321:Rhizaria
2309:Hacrobia
2299:Excavata
2284:Bacteria
2259:Bacteria
2212:21158655
2177:16505550
2142:17642700
2059:21694981
1987:20848810
1853:BBC News
1831:21860109
1787:28081065
1633:21478057
1561:20650909
1493:20577157
1462:20435372
1387:20848811
1356:19770275
1296:32364820
1248:19854586
1212:19324295
1177:20085605
1136:17630334
1085:24905728
1045:PLOS ONE
982:73444389
974:30733176
844:21029984
795:20705517
692:See also
686:colistin
682:Pakistan
481:colistin
457:plasmids
446:Pakistan
440:, 26 in
402:bearing
390:colistin
364:colistin
356:dialysis
352:Coventry
184:such as
175:Pakistan
120:bacteria
100:InterPro
60:blaNDM-1
45:Organism
5347:Biology
5301:Ligases
5071:Enzymes
5017:: Other
4849:Sirtuin
4718:Commons
4617:Biofilm
4596:Fimbria
4581:S-layer
4562:Outside
4423:Bacilli
4339:Uterine
4324:Vaginal
4234:Aerobic
4217:ecology
4172:Medical
3902:SAR324
3158:Clade 2
3058:Clade 1
2777:Elulota
2358:Animals
2279:Archaea
2050:3115299
1778:5687261
1702:1223899
1682:Bibcode
1579:CTVNews
1347:2786356
1127:1932750
1076:4048246
1053:Bibcode
786:2933358
678:Belgian
666:plasmid
533:Tianjin
496:Alberta
488:Ontario
442:Haryana
438:Chennai
411:Chennai
348:E. coli
341:Balkans
333:Croatia
171:Swedish
144:called
142:enzymes
96:Domains
66:UniProt
5333:Portal
5275:Lyases
5015:3.5.99
4818:(ACY2)
4796:Urease
4663:Monera
4433:Spiral
4225:Oxygen
4067:others
3941:others
2616:Low GC
2396:others
2336:Plants
2273:Domain
2210:
2175:
2140:
2057:
2047:
1985:
1829:
1785:
1775:
1700:
1631:
1559:
1491:
1460:
1423:
1385:
1354:
1344:
1302:
1294:
1286:
1246:
1210:
1175:
1134:
1124:
1083:
1073:
1024:
980:
972:
964:
842:
793:
783:
672:Deaths
646:
617:Lancet
603:Lancet
529:Nankai
471:, and
315:Mumbai
238:enzyme
116:enzyme
114:is an
71:C7C422
57:Symbol
16:Enzyme
5227:Types
4992:3.5.5
4975:AICDA
4927:3.5.4
4894:3.5.3
4861:3.5.2
4773:3.5.1
4591:Pilus
4545:only:
4525:Porin
4517:only:
4496:only:
4418:Cocci
4394:Shape
4314:Mouth
4287:Other
2363:Fungi
1698:S2CID
1415:[
1300:S2CID
1022:S2CID
978:S2CID
942:(PDF)
727:MCR-1
452:NDM-1
433:NDM-1
417:NDM-1
406:NDM-1
321:NDM-1
310:NDM-1
269:NDM-1
240:that
229:NDM-1
112:NDM-1
5319:list
5312:EC7
5306:list
5299:EC6
5293:list
5286:EC5
5280:list
5273:EC4
5267:list
5260:EC3
5254:list
5247:EC2
5241:list
5234:EC1
4822:ACY3
4811:ACY1
4766:3.5)
4634:and
4452:Cell
4319:Skin
4309:Lung
4215:and
2794:ABY1
2208:PMID
2173:PMID
2138:PMID
2073:link
2055:PMID
1983:PMID
1956:2010
1827:PMID
1783:PMID
1724:2017
1655:2017
1629:PMID
1557:PMID
1520:2010
1489:PMID
1458:PMID
1421:ISBN
1383:PMID
1352:PMID
1292:PMID
1284:ISSN
1244:PMID
1208:PMID
1173:PMID
1132:PMID
1081:PMID
970:PMID
962:ISSN
924:2016
872:2010
840:PMID
791:PMID
597:The
575:EDTA
531:and
525:Rice
494:and
362:and
190:and
156:and
4486:DAP
4481:NAG
4476:NAM
4304:Gut
3619:BV2
2612:BV3
2198:doi
2194:363
2163:doi
2128:doi
2045:PMC
2035:doi
1817:doi
1773:PMC
1765:doi
1690:doi
1621:doi
1547:doi
1450:doi
1342:PMC
1334:doi
1276:doi
1236:doi
1200:doi
1163:doi
1122:PMC
1114:doi
1071:PMC
1061:doi
1012:doi
954:doi
832:doi
781:PMC
773:doi
455:on
450:bla
431:bla
415:bla
404:bla
319:bla
308:bla
267:bla
256:KPC
227:bla
5359::
4764:EC
4656::
4469::
4162::
4077:"
4015:"
4003:"
3921:"
3853:"
3841:"
3829:"
3817:"
3803:"
3788:"
3776:"
3729:"
3697:"
3675:"
3637:"
3587:"
3565:"
3553:"
3538:"
3526:"
3483:"
3468:"
3435:"
3416:"
3243:"
3218:"
3206:"
3187:"
3175:"
3135:"
3080:"
3068:"
3025:"
3013:"
3001:"
2954:"
2942:"
2791:"
2779:"
2702:"
2585:"
2499:"
2447:"
2257::
2206:.
2192:.
2188:.
2171:.
2159:24
2157:.
2153:.
2136:.
2124:22
2122:.
2118:.
2069:}}
2065:{{
2053:.
2029:.
2025:.
2006:.
1995:^
1979:58
1977:.
1973:.
1945:.
1933:^
1923:.
1905:.
1887:.
1869:.
1851:.
1839:^
1825:.
1813:29
1811:.
1807:.
1795:^
1781:.
1771:.
1761:66
1759:.
1755:.
1696:.
1688:.
1676:.
1663:^
1627:.
1617:11
1615:.
1595:.
1577:.
1555:.
1543:65
1541:.
1537:.
1485:59
1483:.
1479:.
1456:.
1446:75
1444:.
1379:58
1377:.
1373:.
1350:.
1340:.
1330:53
1328:.
1324:.
1312:^
1298:.
1290:.
1282:.
1272:26
1270:.
1266:.
1242:.
1232:58
1206:.
1194:.
1171:.
1159:16
1157:.
1153:.
1130:.
1120:.
1110:20
1108:.
1102:.
1079:.
1069:.
1059:.
1047:.
1043:.
1020:.
1006:.
1002:.
990:^
976:.
968:.
960:.
950:20
948:.
944:.
915:.
909:.
888:.
861:.
838:.
828:10
826:.
789:.
779:.
769:10
767:.
763:.
751:^
652:,
527:,
483:.
467:,
420:.
343:.
198:.
160:.
5335::
5321:)
5317:(
5308:)
5304:(
5295:)
5291:(
5282:)
5278:(
5269:)
5265:(
5256:)
5252:(
5243:)
5239:(
5063:e
5056:t
5049:v
4752:e
4745:t
4738:v
4330:)
4326:(
4152:e
4145:t
4138:v
4096:"
4092:"
4089:"
4085:"
4073:"
4046:"
4042:"
4039:"
4035:"
4032:"
4028:"
4011:"
3999:"
3984:"
3980:"
3977:"
3973:"
3956:"
3952:"
3933:"
3929:"
3917:"
3914:"
3910:"
3849:"
3837:"
3825:"
3813:"
3799:"
3784:"
3772:"
3725:"
3693:"
3671:"
3633:"
3606:"
3602:"
3599:"
3595:"
3583:"
3580:"
3576:"
3561:"
3549:"
3534:"
3522:"
3479:"
3464:"
3461:"
3457:"
3454:"
3450:"
3447:"
3443:"
3431:"
3428:"
3424:"
3412:"
3386:"
3382:"
3279:"
3275:"
3255:"
3251:"
3239:"
3214:"
3202:"
3199:"
3195:"
3183:"
3171:"
3168:"
3164:"
3150:"
3146:"
3131:"
3128:"
3124:"
3121:"
3117:"
3101:"
3097:"
3076:"
3064:"
3037:"
3033:"
3021:"
3009:"
2997:"
2950:"
2938:"
2852:"
2848:"
2830:"
2826:"
2820:"
2816:"
2807:"
2803:"
2787:"
2775:"
2753:"
2749:"
2741:"
2737:"
2698:"
2665:"
2661:"
2644:"
2640:"
2632:"
2628:"
2581:"
2576:"
2572:"
2536:"
2532:"
2495:"
2490:"
2486:"
2443:"
2370:)
2247:e
2240:t
2233:v
2214:.
2200::
2179:.
2165::
2144:.
2130::
2075:)
2061:.
2037::
2031:9
1989:.
1958:.
1855:.
1833:.
1819::
1789:.
1767::
1726:.
1704:.
1692::
1684::
1678:1
1657:.
1635:.
1623::
1563:.
1549::
1522:.
1495:.
1464:.
1452::
1429:.
1400:.
1358:.
1336::
1306:.
1278::
1250:.
1238::
1214:.
1202::
1196:9
1179:.
1165::
1138:.
1116::
1087:.
1063::
1055::
1049:9
1028:.
1014::
1008:1
984:.
956::
926:.
874:.
846:.
834::
797:.
775::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
