244:
221:
118:
143:
250:
149:
1502:
1047:. The NPAS4 gene is a neuronal activity-dependent immediate early gene that has been identified as a transcription factor. The protein regulates the transcription of genes that control inhibitory synapse development, synaptic plasticity and most recently reported also behavior.
1085:
to play critical roles in regulating the plasticity of inhibitory neurons. She found that NPAS4 helps to regulate plasticity by orchestrating a redistribution of inhibitory synapses, wherein they are lost from proximal apical dendrites of CA1
1318:"Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression"
257:
156:
1067:
1457:
Funahashi Y, Ariza A, Emi R, Xu Y, Shan W, Suzuki K, Kozawa K, Ahammad RU, Wu M, Takano T, Yura Y, Kuroda K, Nagai T, Amano M, Yamada K, Kaibuchi K (2019).
1205:
Funahashi Y, Ariza A, Emi R, Xu Y, Shan W, Suzuki K, Kozawa K, Ahammad RU, Wu M, Takano T, Yura Y, Kuroda K, Nagai T, Amano M, Yamada K, Kaibuchi K (2019).
1559:
769:
750:
79:
1584:
1547:
1167:
1149:
1579:
1361:"Human variants in the neuronal basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) transcription factor complex NPAS4/ARNT2 disrupt function"
243:
1078:) class of transcriptional regulators, which are involved in a wide range of physiologic and developmental events (Ooe et al., 2004 )..
977:
220:
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1136:
1115:
142:
117:
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1111:
59:
256:
155:
1540:
249:
148:
814:
67:
795:
1059:
1414:"A reduction in Npas4 expression results in delayed neural differentiation of mouse embryonic stem cells"
1533:
131:
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39:
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1218:
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336:
267:
211:
166:
87:
311:
1459:"Phosphorylation of Npas4 by MAPK Regulates Reward-Related Gene Expression and Behaviors"
1207:"Phosphorylation of Npas4 by MAPK Regulates Reward-Related Gene Expression and Behaviors"
1376:
1263:
1248:"The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition"
1440:
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National Center for
Biotechnology Information, U.S. National Library of Medicine
1154:
National Center for
Biotechnology Information, U.S. National Library of Medicine
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1185:
1246:
Bloodgood BL, Sharma N, Browne HA, Trepman AZ, Greenberg ME (2013-11-07).
1024:
1019:
1008:
859:
840:
1271:
533:
DNA-binding transcription activator activity, RNA polymerase II-specific
1412:
Klaric TS, Thomas PQ, Dottori M, Leong WK, Koblar SA, Lewis MD (2014).
1040:
826:
781:
992:
736:
558:
DNA-binding transcription factor activity, RNA polymerase II-specific
543:
RNA polymerase II cis-regulatory region sequence-specific DNA binding
1501:
1430:
699:
695:
1509:
1071:
1063:
1044:
63:
50:, Le-PAS, NXF, PASD10, bHLHe79, neuronal PAS domain protein 4
615:
positive regulation of transcription by RNA polymerase II
319:
1521:
1316:
Ooe N, Saito K, Mikami N, Nakatuka I, Kaneko H (2004).
1359:
Bersten DC, Bruning JB, Peet DJ, Whitelaw ML (2014).
484:
953:
928:
902:
877:
600:
positive regulation of transcription, DNA-templated
451:
dentate gyrus of hippocampal formation granule cell
1128:
1126:
1124:
1107:
1105:
1103:
266:
165:
685:regulation of transcription by RNA polymerase II
16:Protein-coding gene in the species Homo sapiens
1133:GRCm38: Ensembl release 89: ENSMUSG00000045903
655:regulation of synaptic transmission, GABAergic
1541:
8:
1186:"Entrez Gene: Neuronal PAS domain protein 4"
610:cellular response to corticosterone stimulus
1112:GRCh38: Ensembl release 89: ENSG00000174576
1560:United States National Library of Medicine
1548:
1534:
710:
605:regulation of transcription, DNA-templated
510:
307:
206:
103:
1474:
1439:
1429:
1394:
1384:
1341:
1287:
1222:
1558:This article incorporates text from the
1099:
1043:that in humans is encoded by the NPAS4
20:
271:
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170:
129:
124:
7:
1498:
1496:
553:protein heterodimerization activity
1520:. You can help Knowledge (XXG) by
950:
925:
899:
874:
850:
831:
805:
786:
760:
741:
625:transcription by RNA polymerase II
489:
407:
345:
324:
14:
675:inhibitory postsynaptic potential
670:excitatory postsynaptic potential
665:regulation of synaptic plasticity
1500:
255:
248:
242:
219:
154:
147:
141:
116:
579:transcription regulator complex
1585:Human chromosome 11 gene stubs
473:More reference expression data
1:
1334:10.1128/mcb.24.2.608-616.2004
1090:and increased on the somata.
1037:Neuronal PAS domain protein 4
538:protein dimerization activity
381:muscle layer of sigmoid colon
240:
139:
1580:Genes on human chromosome 11
1476:10.1016/j.celrep.2019.10.116
1386:10.1371/journal.pone.0085768
1224:10.1016/j.celrep.2019.10.116
620:transcription, DNA-templated
680:inhibitory synapse assembly
1601:
1495:
630:nervous system development
1168:"Mouse PubMed Reference:"
1150:"Human PubMed Reference:"
1058:NPAS4 is a member of the
1023:
1018:
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1007:
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138:
115:
106:
102:
57:
54:
44:
37:
32:
28:
23:
1081:NPAS4 has been shown by
978:Chr 11: 66.42 – 66.43 Mb
1060:basic helix-loop-helix
985:Chr 19: 5.03 – 5.04 Mb
455:neural layer of retina
431:superior frontal gyrus
435:primary visual cortex
234:Chromosome 19 (mouse)
132:Chromosome 11 (human)
1469:(10): 3235–3252.e9.
1217:(10): 3235–3252.e9.
1083:Dr. Brenda Bloodgood
650:cell differentiation
389:smooth muscle tissue
1377:2014PLoSO...985768B
1272:10.1038/nature12743
1264:2013Natur.503..121B
423:islet of Langerhans
1562:, which is in the
1508:This article on a
1418:Stem Cell Res Ther
815:ENSMUSG00000045903
593:Biological process
567:Cellular component
521:Molecular function
365:anterior pituitary
1529:
1528:
1258:(7474): 121–125.
1088:pyramidal neurons
1034:
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1002:
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640:short-term memory
505:
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479:
478:
466:
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459:cerebellar cortex
443:nucleus accumbens
439:prefrontal cortex
404:
403:
373:left uterine tube
302:
301:
201:
200:
96:NPAS4 - orthologs
1592:
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1016:
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922:RefSeq (protein)
912:
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851:
832:
806:
787:
761:
742:
711:
645:long-term memory
511:
490:
475:
415:
413:Top expressed in
408:
393:popliteal artery
353:
351:Top expressed in
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1431:10.1186/scrt453
1411:
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1322:Mol. Cell. Biol
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1309:Further reading
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1025:View/Edit Mouse
1020:View/Edit Human
983:
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973:Location (UCSC)
959:
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796:ENSG00000174576
689:
660:social behavior
588:
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548:protein binding
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361:pituitary gland
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210:Gene location (
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107:Gene location (
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427:female urethra
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312:RNA expression
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1565:
1564:public domain
1561:
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1514:chromosome 11
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1382:
1378:
1374:
1371:(1): e85768.
1370:
1366:
1362:
1357:
1353:
1349:
1344:
1339:
1335:
1331:
1328:(2): 608–16.
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871:RefSeq (mRNA)
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515:Gene ontology
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27:
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19:
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1522:expanding it
1507:
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1463:Cell Reports
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1211:Cell Reports
1210:
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1189:. Retrieved
1180:
1171:
1162:
1153:
1144:
1080:
1057:
1049:
1036:
1035:
958:
936:NP_001305733
933:
907:
889:NM_001318804
882:
858:
839:
813:
794:
768:
749:
729:
724:
335:
328:
273:19|19 A
55:External IDs
18:
574:postsynapse
528:DNA binding
193:66,426,707
180:66,421,004
33:Identifiers
1574:Categories
1191:2017-10-15
1139:, May 2017
1118:, May 2017
1094:References
339:(ortholog)
294:5,040,344
281:5,034,383
76:HomoloGene
1512:on human
1424:(3): 64.
1280:1476-4687
961:NP_705781
940:NP_849195
910:NM_153553
885:NM_178864
715:Orthologs
84:GeneCards
1485:31801086
1450:24887558
1405:24465693
1365:PLOS ONE
1352:14701734
1298:24201284
1233:31801086
1135:–
1114:–
1054:Function
1009:Wikidata
694:Sources:
635:learning
1441:4076635
1396:3894988
1373:Bibcode
1289:4169177
1260:Bibcode
1137:Ensembl
1116:Ensembl
1041:protein
827:UniProt
782:Ensembl
721:Species
700:QuickGO
584:nucleus
314:pattern
172:11q13.2
72:2664186
40:Aliases
1483:
1448:
1438:
1403:
1393:
1350:
1343:343817
1340:
1296:
1286:
1278:
1252:Nature
1231:
1074:(bHLH-
995:search
993:PubMed
860:Q8BGD7
841:Q8IUM7
770:225872
751:266743
737:Entrez
485:BioGPS
64:608554
1516:is a
1039:is a
730:Mouse
725:Human
696:Amigo
369:gonad
337:Mouse
330:Human
277:Start
212:Mouse
176:Start
109:Human
88:NPAS4
80:15333
47:NPAS4
24:NPAS4
1518:stub
1510:gene
1481:PMID
1446:PMID
1401:PMID
1348:PMID
1294:PMID
1276:ISSN
1229:PMID
1068:ARNT
1045:gene
320:Bgee
268:Band
229:Chr.
167:Band
126:Chr.
60:OMIM
1471:doi
1436:PMC
1426:doi
1391:PMC
1381:doi
1338:PMC
1330:doi
1284:PMC
1268:doi
1256:503
1219:doi
1076:PAS
1072:SIM
1064:PER
493:n/a
290:End
189:End
92:OMA
68:MGI
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1123:^
1102:^
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296:bp
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182:bp
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1566:.
1549:e
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