2034:
185:
177:
172:
of 93-95 residues with 14 cysteine residues forming 7 disulfide bridges . Domain I contains a COOH terminal with a disulfide loop; domain II lacks this COOH terminal disulfide loop . Based on the resemblance of the disulfide loop present on vasopressin and oxytocin, it is suggested that the hormones
85:
Neurophysins are also secreted out of the posterior pituitary hypothalamus, each carrying their respective associated passenger hormone. When the posterior pituitary hypothalamus secretes vasopressin and its neurophysin carrier, it also secretes a
77:
digestion via enzymes. However, due to the low concentration of neurophysin in the blood, it is likely the protein-hormone complex dissociates, indicating the neurophysin does not aid in transporting the hormone through the
1296:
1289:
1282:
73:
aid in intra-axonal transport. During intra-axonal transport, the neurophysin's are believed to prevent the bound hormone from leaking into the cytoplasmic space and
1249:
148:
Although not enough data has been obtained, it is hypothesized that there is a common precursor molecule between neurophysin and the two hormones it stabilizes.
696:
1169:
681:
479:
390:
795:
127:
2075:
429:
686:
727:
732:
1707:
1563:
1811:
1516:
1159:
747:
474:
383:
1174:
544:
2104:
788:
589:
69:
interactions. Stabilizing neurophysin-hormone complexes that are formed within neurosecretory granules located in the
2099:
2068:
757:
558:
411:
145:
in which a precursor molecule of higher molecular weight is proteolytically cleaved and forms disulfide linkages.
2094:
1194:
656:
376:
70:
548:
362:
762:
636:
584:
50:
1384:
1244:
781:
752:
2061:
613:
62:
1554:
1309:
1219:
1214:
1204:
1189:
722:
618:
156:
Neurophysins are acidic proteins with a molecular weight of approximately 10,000 Da that are rich in
1434:
1046:
434:
46:
1880:
1791:
1786:
1642:
1637:
853:
1379:
1374:
1312:
878:
673:
219:
123:
79:
54:
1944:
1939:
1895:
1496:
1491:
1446:
1396:
1364:
1344:
1334:
1964:
1781:
1652:
1632:
1481:
1476:
1456:
1274:
1983:
1959:
1954:
1949:
1915:
1801:
1697:
1320:
1305:
883:
822:
337:
296:
261:
169:
1766:
2033:
1910:
1692:
1687:
1672:
1534:
1416:
691:
327:
288:
253:
1461:
1354:
1209:
934:
924:
540:
465:
403:
31:
173:
form covalent linkages to this disulfide loop present on the COOH terminal of domain I.
358:
292:
257:
2045:
2015:
1974:
1539:
1229:
1224:
957:
952:
929:
831:
663:
531:
198:
106:
332:
2088:
2011:
906:
901:
868:
737:
601:
563:
526:
97:
66:
184:
2041:
1855:
1825:
1741:
1721:
1597:
1110:
1105:
1100:
1095:
1062:
1057:
808:
131:
87:
58:
2007:
1860:
1845:
1830:
1771:
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1736:
1726:
1662:
1602:
1592:
1587:
1577:
1349:
1239:
1149:
1077:
1052:
988:
973:
893:
863:
848:
701:
553:
469:
110:
74:
42:
1934:
1900:
1890:
1885:
1875:
1776:
1682:
1627:
1622:
1521:
1411:
1339:
1254:
1041:
1005:
995:
978:
944:
916:
873:
368:
218:
Airaodion AI, Ekenjoku JA, Ogbuagu EO, Okoroukwu VN, Ogbuagu U (2019-10-22).
141:-rich neurophysin protein is suggested to be congruent with the synthesis of
1905:
1865:
1840:
1751:
1731:
1657:
1607:
1582:
1544:
1529:
1506:
1486:
1471:
1466:
1451:
1441:
1389:
1359:
1179:
1164:
1010:
1000:
983:
840:
742:
706:
138:
65:
granules, the analogous neurophysin I and II form stabilizing complexes via
17:
773:
341:
176:
1850:
1677:
1617:
1511:
1429:
1406:
1369:
1154:
1133:
1128:
1072:
300:
265:
157:
101:
38:
315:
1979:
1835:
1761:
1647:
1401:
1199:
1184:
804:
399:
165:
161:
142:
35:
1667:
1120:
514:
509:
504:
499:
494:
489:
484:
279:
Breslow E (June 1979). "Chemistry and biology of the neurophysins".
244:
Breslow E (June 1979). "Chemistry and biology of the neurophysins".
1033:
449:
444:
439:
424:
419:
183:
175:
651:
646:
641:
1278:
777:
372:
1259:
122:
These proteins are synthesized in the cell bodies of the
2049:
224:
Asian
Research Journal of Gynaecology and Obstetrics
180:
Neurophysin II protein domain unbound to vasopressin
1997:
1924:
1810:
1706:
1562:
1553:
1319:
1142:
1119:
1088:
1032:
1023:
966:
943:
915:
892:
839:
830:
815:
715:
672:
629:
572:
458:
410:
168:residues . The protein is double domain with a
1250:Pituitary adenylate cyclase-activating peptide
220:"Carica papaya Leaves Might Cause Miscarriage"
2069:
1290:
1170:Cocaine- and amphetamine-regulated transcript
789:
384:
113:(Also known as "antidiuretic hormone" or ADH)
8:
2076:
2062:
1559:
1297:
1283:
1275:
1029:
836:
796:
782:
774:
480:Insulin-like growth factor binding protein
391:
377:
369:
361:at the U.S. National Library of Medicine
331:
210:
7:
2030:
2028:
239:
237:
235:
233:
320:The Journal of Biological Chemistry
293:10.1146/annurev.bi.48.070179.001343
258:10.1146/annurev.bi.48.070179.001343
25:
733:Cholesterylester transfer protein
2032:
1160:Calcitonin gene-related peptide
748:Latent TGF-beta binding protein
697:Photosynthetic Reaction Centers
682:Plant Light-Harvesting Complex
475:Growth hormone binding protein
316:"The structure of neurophysin"
1:
333:10.1016/S0021-9258(19)69652-3
281:Annual Review of Biochemistry
246:Annual Review of Biochemistry
2048:. You can help Knowledge by
1175:Delta-sleep-inducing peptide
545:Sex hormone binding globulin
188:Neurophysin-Oxytocin complex
118:Biosynthesis of Neurophysins
590:Calmodulin-binding proteins
61:, respectively. Inside the
2121:
2027:
758:Membrane transport protein
559:Thyroxine-binding globulin
1866:Vasotocin (argiprestocin)
1861:Vasopressin (argipressin)
1752:Vasotocin (argiprestocin)
1747:Vasopressin (argipressin)
1608:Vasotocin (argiprestocin)
1603:Vasopressin (argipressin)
1390:Vasotocin (argiprestocin)
1195:Gastrin-releasing peptide
687:Orange Carotenoid Protein
71:posterior pituitary gland
549:Androgen binding protein
363:Medical Subject Headings
763:Odorant binding protein
637:Retinol binding protein
585:Calcium-binding protein
314:Drenth J (March 1981).
1782:ORG-52186 (SCH-740935)
1504:Catabolism inhibitors:
1245:Pancreatic polypeptide
753:Major urinary proteins
189:
181:
614:Iron-binding proteins
187:
179:
93:There are two types:
1310:vasopressin receptor
1190:Galanin-like peptide
723:Acyl carrier protein
619:Transferrin receptor
34:which transport the
1512:Bestatin (ubenimex)
743:GTP-binding protein
47:posterior pituitary
2105:Biochemistry stubs
190:
182:
80:circulatory system
55:supraoptic nucleus
2100:Biological matter
2057:
2056:
2025:
2024:
2005:Carrier proteins:
1993:
1992:
1984:lithium carbonate
1972:Other inhibitors:
1524:
1380:PF-06655075 (PF1)
1272:
1271:
1268:
1267:
1019:
1018:
771:
770:
170:polypeptide chain
16:(Redirected from
2112:
2095:Membrane biology
2078:
2071:
2064:
2036:
2029:
1560:
1535:o-Phenanthroline
1522:
1299:
1292:
1285:
1276:
1030:
837:
798:
791:
784:
775:
692:Phycobiliprotein
404:carrier proteins
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386:
379:
370:
346:
345:
335:
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305:
304:
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228:
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32:carrier proteins
21:
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2114:
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2109:
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2083:
2082:
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1989:
1920:
1815:
1806:
1711:
1702:
1567:
1549:
1355:Lipo-oxytocin-1
1315:
1303:
1273:
1264:
1220:Neuropeptide VF
1215:Neuropeptide SF
1210:Neuropeptide FF
1205:Neuropeptide AF
1138:
1115:
1084:
1025:
1015:
962:
939:
911:
888:
857:
832:Opioid peptides
826:
811:
802:
772:
767:
728:Adaptor protein
711:
668:
625:
568:
541:steroid hormone
466:peptide hormone
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312:
308:
278:
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231:
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130:regions of the
128:paraventricular
120:
51:paraventricular
23:
22:
15:
12:
11:
5:
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2107:
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1975:Demeclocycline
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1585:
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1557:
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1540:Phosphoramidon
1537:
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1270:
1269:
1266:
1265:
1263:
1262:
1257:
1252:
1247:
1242:
1237:
1232:
1230:Neuropeptide Y
1227:
1225:Neuropeptide S
1222:
1217:
1212:
1207:
1202:
1197:
1192:
1187:
1182:
1177:
1172:
1167:
1162:
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1137:
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1125:
1123:
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1098:
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1075:
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1038:
1036:
1027:
1021:
1020:
1017:
1016:
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1008:
1003:
998:
993:
992:
991:
981:
976:
970:
968:
964:
963:
961:
960:
958:Leu-enkephalin
955:
953:Met-enkephalin
949:
947:
941:
940:
938:
937:
932:
927:
921:
919:
913:
912:
910:
909:
904:
898:
896:
890:
889:
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884:β-Neoendorphin
881:
879:α-Neoendorphin
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828:
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664:Transcobalamin
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353:External links
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199:Herring bodies
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107:Neurophysin II
104:
63:neurosecretory
24:
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13:
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3:
2:
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2044:article is a
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1463:
1460:
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1455:
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1450:
1448:
1445:
1443:
1440:
1436:
1435:Tocinoic acid
1433:
1431:
1428:
1425:
1422:
1421:
1418:
1415:
1413:
1410:
1408:
1405:
1403:
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1311:
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1300:
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1039:
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1031:
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1026:neuropeptides
1022:
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1002:
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907:Endomorphin-2
905:
903:
902:Endomorphin-1
900:
899:
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895:
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882:
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877:
875:
872:
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869:Big dynorphin
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754:
751:
749:
746:
744:
741:
739:
738:F-box protein
736:
734:
731:
729:
726:
724:
721:
720:
718:
714:
708:
705:
703:
700:
698:
695:
693:
690:
688:
685:
683:
680:
679:
677:
675:
671:
665:
662:
658:
655:
653:
650:
648:
645:
643:
640:
639:
638:
635:
634:
632:
628:
620:
617:
615:
612:
611:
610:
607:
603:
602:Ceruloplasmin
600:
599:
598:
595:
591:
588:
586:
583:
582:
581:
578:
577:
575:
573:Metal/element
571:
565:
564:Transthyretin
562:
560:
557:
555:
552:
550:
546:
542:
539:
538:
533:
530:
528:
527:Neurophysin I
525:
524:
523:
520:
516:
513:
511:
508:
506:
503:
501:
498:
496:
493:
491:
488:
486:
483:
482:
481:
478:
476:
473:
471:
467:
464:
463:
461:
457:
451:
448:
446:
443:
441:
438:
436:
433:
431:
428:
426:
423:
421:
418:
417:
415:
413:
409:
405:
401:
394:
389:
387:
382:
380:
375:
374:
371:
364:
360:
357:
356:
352:
343:
339:
334:
329:
326:(6): 2601–2.
325:
321:
317:
310:
307:
302:
298:
294:
290:
287:(1): 251–74.
286:
282:
275:
272:
267:
263:
259:
255:
252:(1): 251–74.
251:
247:
240:
238:
236:
234:
230:
225:
221:
214:
211:
204:
200:
197:
196:
192:
186:
178:
174:
171:
167:
163:
159:
151:
149:
146:
144:
140:
135:
133:
129:
125:
117:
112:
108:
105:
103:
99:
98:Neurophysin I
96:
95:
94:
91:
89:
83:
81:
76:
72:
68:
64:
60:
56:
52:
48:
44:
40:
37:
33:
29:
19:
2050:expanding it
2042:biochemistry
2039:
2004:
1971:
1932:Antagonists:
1931:
1881:JNJ-17079166
1873:Antagonists:
1872:
1856:Terlipressin
1826:Desmopressin
1822:
1798:
1792:TASP-0390325
1787:TASP-0233278
1759:Antagonists:
1758:
1742:Terlipressin
1722:Desmopressin
1718:
1643:JNJ-17308616
1638:JNJ-17079166
1615:Antagonists:
1614:
1598:Terlipressin
1574:
1503:
1439:Non-peptide:
1438:
1426:
1424:Antagonists:
1423:
1394:Non-peptide:
1393:
1331:
1328:
1235:Neurophysins
1234:
1063:Neurokinin B
1058:Neurokinin A
894:Endomorphins
820:
608:
596:
579:
522:Neurophysins
521:
359:Neurophysins
323:
319:
309:
284:
280:
274:
249:
245:
223:
213:
155:
147:
136:
132:hypothalamus
121:
92:
88:glycopeptide
84:
59:hypothalamus
28:Neurophysins
27:
26:
2008:Neurophysin
1846:Ornipressin
1831:Felypressin
1772:Brezivaptan
1737:Ornipressin
1727:Felypressin
1663:Relcovaptan
1593:Selepressin
1588:Ornipressin
1578:Felypressin
1555:Vasopressin
1525:-Methionine
1375:PF-06478939
1350:Demoxytocin
1240:Neurotensin
1150:Angiotensin
1089:Neuromedins
1078:Physalaemin
1053:Substance P
1047:Tachykinins
1042:Bradykinins
989:Hemorphin-4
974:Adrenorphin
945:Enkephalins
935:γ-Endorphin
930:β-Endorphin
925:α-Endorphin
864:Dynorphin B
854:Dynorphin A
849:Dynorphin A
702:Phytochrome
554:Transcortin
470:Follistatin
111:Vasopressin
75:proteolytic
43:vasopressin
18:Neurophysin
2089:Categories
1945:RWJ-339489
1940:Ribuvaptan
1935:Balovaptan
1901:Satavaptan
1896:RWJ-351647
1891:Mozavaptan
1886:Lixivaptan
1876:Conivaptan
1777:Nelivaptan
1683:WAY-267464
1628:Conivaptan
1623:Balovaptan
1497:WAY-162720
1492:SSR-126768
1447:Cligosiban
1412:WAY-267464
1365:Nacartocin
1345:Cargutocin
1340:Carbetocin
1335:Aspartocin
1313:modulators
1069:amphibian
1006:Spinorphin
996:Nociceptin
979:Amidorphin
917:Endorphins
874:Leumorphin
841:Dynorphins
412:Fatty acid
205:References
124:supraoptic
1965:YM-222546
1906:Tolvaptan
1841:Lypressin
1823:Agonists:
1732:Lypressin
1719:Agonists:
1658:PF-184563
1653:LY-307174
1633:FR-218944
1583:Lypressin
1575:Agonists:
1545:Puromycin
1530:Leupeptin
1507:Amastatin
1487:Retosiban
1482:Nolasiban
1477:L-372,662
1472:L-371,257
1467:L-368,899
1457:Erlosiban
1452:Epelsiban
1442:Barusiban
1360:Merotocin
1329:Agonists:
1180:FMRFamide
1165:Carnosine
1049:: mammal
1011:Valorphin
1001:Opiorphin
984:Hemorphin
707:Rhodopsin
152:Structure
139:disulfide
49:from the
1960:VMAX-382
1955:VMAX-372
1950:VMAX-367
1925:Unsorted
1916:YM-35471
1851:TC OT 39
1802:TASP-699
1799:Ligands:
1698:YM-35471
1678:TC OT 39
1618:Atosiban
1430:Atosiban
1427:Peptide:
1407:TC OT 39
1370:Oxytocin
1332:Peptide:
1321:Oxytocin
1306:Oxytocin
1155:Bombesin
1073:Kassinin
823:hormones
816:Hormones
805:Peptides
400:Proteins
193:See also
158:cysteine
102:Oxytocin
67:covalent
39:oxytocin
36:hormones
1980:Lithium
1836:LIT-001
1767:ABT-558
1762:ABT-436
1648:LIT-001
1402:LIT-001
1255:RVD-Hpα
1200:Ghrelin
1185:Galanin
1121:Orexins
674:Pigment
630:Vitamin
580:calcium
459:Hormone
342:7204368
166:proline
162:glycine
143:insulin
57:of the
45:to the
1998:Others
1911:YM-471
1693:YM-471
1688:YM-218
1673:SRX251
1668:SRX246
1417:WJ0679
1034:Kinins
967:Others
597:copper
515:IGFBP7
510:IGFBP6
505:IGFBP5
500:IGFBP4
495:IGFBP3
490:IGFBP2
485:IGFBP1
365:(MeSH)
340:
301:382985
299:
266:382985
264:
226:: 1–9.
164:, and
2040:This
1462:IX-01
1143:Other
1024:Other
716:Other
450:FABP7
445:FABP6
440:FABP5
435:FABP4
430:FABP3
425:FABP2
420:FABP1
2046:stub
1517:EDTA
1385:TGOT
1308:and
821:see
609:iron
338:PMID
297:PMID
262:PMID
137:The
126:and
53:and
41:and
30:are
1397:CA7
1260:VGF
856:1–8
328:doi
324:256
289:doi
254:doi
134:.
2091::
2016:II
2014:,
1710:1B
1566:1A
1437:;
1392:;
807::
543::
532:II
468::
402::
336:.
322:.
318:.
295:.
285:48
283:.
260:.
250:48
248:.
232:^
222:.
160:,
109:-
100:-
90:.
82:.
2077:e
2070:t
2063:v
2052:.
2018:)
2012:I
2010:(
1986:)
1982:(
1814:2
1812:V
1708:V
1564:V
1523:L
1298:e
1291:t
1284:v
1134:B
1129:A
1111:U
1106:S
1101:N
1096:B
797:e
790:t
783:v
657:4
652:3
647:2
642:1
547:/
392:e
385:t
378:v
344:.
330::
303:.
291::
268:.
256::
20:)
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