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Neurophysins

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of 93-95 residues with 14 cysteine residues forming 7 disulfide bridges . Domain I contains a COOH terminal with a disulfide loop; domain II lacks this COOH terminal disulfide loop . Based on the resemblance of the disulfide loop present on vasopressin and oxytocin, it is suggested that the hormones
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Neurophysins are also secreted out of the posterior pituitary hypothalamus, each carrying their respective associated passenger hormone. When the posterior pituitary hypothalamus secretes vasopressin and its neurophysin carrier, it also secretes a
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digestion via enzymes. However, due to the low concentration of neurophysin in the blood, it is likely the protein-hormone complex dissociates, indicating the neurophysin does not aid in transporting the hormone through the
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aid in intra-axonal transport. During intra-axonal transport, the neurophysin's are believed to prevent the bound hormone from leaking into the cytoplasmic space and
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Although not enough data has been obtained, it is hypothesized that there is a common precursor molecule between neurophysin and the two hormones it stabilizes.
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interactions. Stabilizing neurophysin-hormone complexes that are formed within neurosecretory granules located in the
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in which a precursor molecule of higher molecular weight is proteolytically cleaved and forms disulfide linkages.
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Neurophysins are acidic proteins with a molecular weight of approximately 10,000 Da that are rich in
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form covalent linkages to this disulfide loop present on the COOH terminal of domain I.
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Airaodion AI, Ekenjoku JA, Ogbuagu EO, Okoroukwu VN, Ogbuagu U (2019-10-22).
141:-rich neurophysin protein is suggested to be congruent with the synthesis of 1905: 1865: 1840: 1751: 1731: 1657: 1607: 1582: 1544: 1529: 1506: 1486: 1471: 1466: 1451: 1441: 1389: 1359: 1179: 1164: 1010: 1000: 983: 840: 742: 706: 138: 65:
granules, the analogous neurophysin I and II form stabilizing complexes via
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Breslow E (June 1979). "Chemistry and biology of the neurophysins".
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Breslow E (June 1979). "Chemistry and biology of the neurophysins".
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These proteins are synthesized in the cell bodies of the
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Asian Research Journal of Gynaecology and Obstetrics
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Neurophysin II protein domain unbound to vasopressin
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The protein is double domain with a 1250:Pituitary adenylate cyclase-activating peptide 220:"Carica papaya Leaves Might Cause Miscarriage" 2069: 1290: 1170:Cocaine- and amphetamine-regulated transcript 789: 384: 113:(Also known as "antidiuretic hormone" or ADH) 8: 2076: 2062: 1559: 1297: 1283: 1275: 1029: 836: 796: 782: 774: 480:Insulin-like growth factor binding protein 391: 377: 369: 361:at the U.S. National Library of Medicine 331: 210: 7: 2030: 2028: 239: 237: 235: 233: 320:The Journal of Biological Chemistry 293:10.1146/annurev.bi.48.070179.001343 258:10.1146/annurev.bi.48.070179.001343 25: 733:Cholesterylester transfer protein 2032: 1160:Calcitonin gene-related peptide 748:Latent TGF-beta binding protein 697:Photosynthetic Reaction Centers 682:Plant Light-Harvesting Complex 475:Growth hormone binding protein 316:"The structure of neurophysin" 1: 333:10.1016/S0021-9258(19)69652-3 281:Annual Review of Biochemistry 246:Annual Review of Biochemistry 2048:. You can help Knowledge by 1175:Delta-sleep-inducing peptide 545:Sex hormone binding globulin 188:Neurophysin-Oxytocin complex 118:Biosynthesis of Neurophysins 590:Calmodulin-binding proteins 61:, respectively. Inside the 2121: 2027: 758:Membrane transport protein 559:Thyroxine-binding globulin 1866:Vasotocin (argiprestocin) 1861:Vasopressin (argipressin) 1752:Vasotocin (argiprestocin) 1747:Vasopressin (argipressin) 1608:Vasotocin (argiprestocin) 1603:Vasopressin (argipressin) 1390:Vasotocin (argiprestocin) 1195:Gastrin-releasing peptide 687:Orange Carotenoid Protein 71:posterior pituitary gland 549:Androgen binding protein 363:Medical Subject Headings 763:Odorant binding protein 637:Retinol binding protein 585:Calcium-binding protein 314:Drenth J (March 1981). 1782:ORG-52186 (SCH-740935) 1504:Catabolism inhibitors: 1245:Pancreatic polypeptide 753:Major urinary proteins 189: 181: 614:Iron-binding proteins 187: 179: 93:There are two types: 1310:vasopressin receptor 1190:Galanin-like peptide 723:Acyl carrier protein 619:Transferrin receptor 34:which transport the 1512:Bestatin (ubenimex) 743:GTP-binding protein 47:posterior pituitary 2105:Biochemistry stubs 190: 182: 80:circulatory system 55:supraoptic nucleus 2100:Biological matter 2057: 2056: 2025: 2024: 2005:Carrier proteins: 1993: 1992: 1984:lithium carbonate 1972:Other inhibitors: 1524: 1380:PF-06655075 (PF1) 1272: 1271: 1268: 1267: 1019: 1018: 771: 770: 170:polypeptide chain 16:(Redirected from 2112: 2095:Membrane biology 2078: 2071: 2064: 2036: 2029: 1560: 1535:o-Phenanthroline 1522: 1299: 1292: 1285: 1276: 1030: 837: 798: 791: 784: 775: 692:Phycobiliprotein 404:carrier proteins 393: 386: 379: 370: 346: 345: 335: 311: 305: 304: 276: 270: 269: 241: 228: 227: 215: 32:carrier proteins 21: 2120: 2119: 2115: 2114: 2113: 2111: 2110: 2109: 2085: 2084: 2083: 2082: 2026: 2021: 1989: 1920: 1815: 1806: 1711: 1702: 1567: 1549: 1355:Lipo-oxytocin-1 1315: 1303: 1273: 1264: 1220:Neuropeptide VF 1215:Neuropeptide SF 1210:Neuropeptide FF 1205:Neuropeptide AF 1138: 1115: 1084: 1025: 1015: 962: 939: 911: 888: 857: 832:Opioid peptides 826: 811: 802: 772: 767: 728:Adaptor protein 711: 668: 625: 568: 541:steroid hormone 466:peptide hormone 454: 406: 397: 355: 350: 349: 313: 312: 308: 278: 277: 273: 243: 242: 231: 217: 216: 212: 207: 195: 154: 130:regions of the 128:paraventricular 120: 51:paraventricular 23: 22: 15: 12: 11: 5: 2118: 2116: 2108: 2107: 2102: 2097: 2087: 2086: 2081: 2080: 2073: 2066: 2058: 2055: 2054: 2037: 2023: 2022: 2020: 2019: 2001: 1999: 1995: 1994: 1991: 1990: 1988: 1987: 1977: 1975:Demeclocycline 1968: 1967: 1962: 1957: 1952: 1947: 1942: 1937: 1928: 1926: 1922: 1921: 1919: 1918: 1913: 1908: 1903: 1898: 1893: 1888: 1883: 1878: 1869: 1868: 1863: 1858: 1853: 1848: 1843: 1838: 1833: 1828: 1819: 1817: 1813: 1808: 1807: 1805: 1804: 1795: 1794: 1789: 1784: 1779: 1774: 1769: 1764: 1755: 1754: 1749: 1744: 1739: 1734: 1729: 1724: 1715: 1713: 1709: 1704: 1703: 1701: 1700: 1695: 1690: 1685: 1680: 1675: 1670: 1665: 1660: 1655: 1650: 1645: 1640: 1635: 1630: 1625: 1620: 1611: 1610: 1605: 1600: 1595: 1590: 1585: 1580: 1571: 1569: 1565: 1557: 1551: 1550: 1548: 1547: 1542: 1540:Phosphoramidon 1537: 1532: 1527: 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859: 855: 845: 843: 834: 828: 827: 819: 817: 813: 812: 803: 801: 800: 793: 786: 778: 769: 768: 766: 765: 760: 755: 750: 745: 740: 735: 730: 725: 719: 717: 713: 712: 710: 709: 704: 699: 694: 689: 684: 678: 676: 670: 669: 667: 666: 664:Transcobalamin 661: 660: 659: 654: 649: 644: 633: 631: 627: 626: 624: 623: 622: 621: 616: 606: 605: 604: 594: 593: 592: 587: 576: 574: 570: 569: 567: 566: 561: 556: 551: 537: 536: 535: 534: 529: 519: 518: 517: 512: 507: 502: 497: 492: 487: 477: 472: 462: 460: 456: 455: 453: 452: 447: 442: 437: 432: 427: 422: 416: 414: 408: 407: 398: 396: 395: 388: 381: 373: 367: 366: 354: 353:External links 351: 348: 347: 306: 271: 229: 209: 208: 206: 203: 202: 201: 199:Herring bodies 194: 191: 153: 150: 119: 116: 115: 114: 107:Neurophysin II 104: 63:neurosecretory 24: 14: 13: 10: 9: 6: 4: 3: 2: 2117: 2106: 2103: 2101: 2098: 2096: 2093: 2092: 2090: 2079: 2074: 2072: 2067: 2065: 2060: 2059: 2053: 2051: 2047: 2044:article is a 2043: 2038: 2035: 2031: 2017: 2013: 2009: 2006: 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1558: 1556: 1552: 1546: 1543: 1541: 1538: 1536: 1533: 1531: 1528: 1526: 1520: 1518: 1515: 1513: 1510: 1508: 1505: 1502: 1501: 1498: 1495: 1493: 1490: 1488: 1485: 1483: 1480: 1478: 1475: 1473: 1470: 1468: 1465: 1463: 1460: 1458: 1455: 1453: 1450: 1448: 1445: 1443: 1440: 1436: 1435:Tocinoic acid 1433: 1431: 1428: 1425: 1422: 1421: 1418: 1415: 1413: 1410: 1408: 1405: 1403: 1400: 1398: 1395: 1391: 1388: 1386: 1383: 1381: 1378: 1376: 1373: 1371: 1368: 1366: 1363: 1361: 1358: 1356: 1353: 1351: 1348: 1346: 1343: 1341: 1338: 1336: 1333: 1330: 1327: 1326: 1324: 1322: 1318: 1314: 1311: 1307: 1300: 1295: 1293: 1288: 1286: 1281: 1280: 1277: 1261: 1258: 1256: 1253: 1251: 1248: 1246: 1243: 1241: 1238: 1236: 1233: 1231: 1228: 1226: 1223: 1221: 1218: 1216: 1213: 1211: 1208: 1206: 1203: 1201: 1198: 1196: 1193: 1191: 1188: 1186: 1183: 1181: 1178: 1176: 1173: 1171: 1168: 1166: 1163: 1161: 1158: 1156: 1153: 1151: 1148: 1147: 1145: 1141: 1135: 1132: 1130: 1127: 1126: 1124: 1122: 1118: 1112: 1109: 1107: 1104: 1102: 1099: 1097: 1094: 1093: 1091: 1087: 1079: 1076: 1074: 1071: 1070: 1068: 1064: 1061: 1059: 1056: 1054: 1051: 1050: 1048: 1045: 1043: 1040: 1039: 1037: 1035: 1031: 1028: 1026:neuropeptides 1022: 1012: 1009: 1007: 1004: 1002: 999: 997: 994: 990: 987: 986: 985: 982: 980: 977: 975: 972: 971: 969: 965: 959: 956: 954: 951: 950: 948: 946: 942: 936: 933: 931: 928: 926: 923: 922: 920: 918: 914: 908: 907:Endomorphin-2 905: 903: 902:Endomorphin-1 900: 899: 897: 895: 891: 885: 882: 880: 877: 875: 872: 870: 869:Big dynorphin 867: 865: 862: 858: 852: 851: 850: 847: 846: 844: 842: 838: 835: 833: 829: 825: 824: 818: 814: 810: 809:neuropeptides 806: 799: 794: 792: 787: 785: 780: 779: 776: 764: 761: 759: 756: 754: 751: 749: 746: 744: 741: 739: 738:F-box protein 736: 734: 731: 729: 726: 724: 721: 720: 718: 714: 708: 705: 703: 700: 698: 695: 693: 690: 688: 685: 683: 680: 679: 677: 675: 671: 665: 662: 658: 655: 653: 650: 648: 645: 643: 640: 639: 638: 635: 634: 632: 628: 620: 617: 615: 612: 611: 610: 607: 603: 602:Ceruloplasmin 600: 599: 598: 595: 591: 588: 586: 583: 582: 581: 578: 577: 575: 573:Metal/element 571: 565: 564:Transthyretin 562: 560: 557: 555: 552: 550: 546: 542: 539: 538: 533: 530: 528: 527:Neurophysin I 525: 524: 523: 520: 516: 513: 511: 508: 506: 503: 501: 498: 496: 493: 491: 488: 486: 483: 482: 481: 478: 476: 473: 471: 467: 464: 463: 461: 457: 451: 448: 446: 443: 441: 438: 436: 433: 431: 428: 426: 423: 421: 418: 417: 415: 413: 409: 405: 401: 394: 389: 387: 382: 380: 375: 374: 371: 364: 360: 357: 356: 352: 343: 339: 334: 329: 326:(6): 2601–2. 325: 321: 317: 310: 307: 302: 298: 294: 290: 287:(1): 251–74. 286: 282: 275: 272: 267: 263: 259: 255: 252:(1): 251–74. 251: 247: 240: 238: 236: 234: 230: 225: 221: 214: 211: 204: 200: 197: 196: 192: 186: 178: 174: 171: 167: 163: 159: 151: 149: 146: 144: 140: 135: 133: 129: 125: 117: 112: 108: 105: 103: 99: 98:Neurophysin I 96: 95: 94: 91: 89: 83: 81: 76: 72: 68: 64: 60: 56: 52: 48: 44: 40: 37: 33: 29: 19: 2050:expanding it 2042:biochemistry 2039: 2004: 1971: 1932:Antagonists: 1931: 1881:JNJ-17079166 1873:Antagonists: 1872: 1856:Terlipressin 1826:Desmopressin 1822: 1798: 1792:TASP-0390325 1787:TASP-0233278 1759:Antagonists: 1758: 1742:Terlipressin 1722:Desmopressin 1718: 1643:JNJ-17308616 1638:JNJ-17079166 1615:Antagonists: 1614: 1598:Terlipressin 1574: 1503: 1439:Non-peptide: 1438: 1426: 1424:Antagonists: 1423: 1394:Non-peptide: 1393: 1331: 1328: 1235:Neurophysins 1234: 1063:Neurokinin B 1058:Neurokinin A 894:Endomorphins 820: 608: 596: 579: 522:Neurophysins 521: 359:Neurophysins 323: 319: 309: 284: 280: 274: 249: 245: 223: 213: 155: 147: 136: 132:hypothalamus 121: 92: 88:glycopeptide 84: 59:hypothalamus 28:Neurophysins 27: 26: 2008:Neurophysin 1846:Ornipressin 1831:Felypressin 1772:Brezivaptan 1737:Ornipressin 1727:Felypressin 1663:Relcovaptan 1593:Selepressin 1588:Ornipressin 1578:Felypressin 1555:Vasopressin 1525:-Methionine 1375:PF-06478939 1350:Demoxytocin 1240:Neurotensin 1150:Angiotensin 1089:Neuromedins 1078:Physalaemin 1053:Substance P 1047:Tachykinins 1042:Bradykinins 989:Hemorphin-4 974:Adrenorphin 945:Enkephalins 935:γ-Endorphin 930:β-Endorphin 925:α-Endorphin 864:Dynorphin B 854:Dynorphin A 849:Dynorphin A 702:Phytochrome 554:Transcortin 470:Follistatin 111:Vasopressin 75:proteolytic 43:vasopressin 18:Neurophysin 2089:Categories 1945:RWJ-339489 1940:Ribuvaptan 1935:Balovaptan 1901:Satavaptan 1896:RWJ-351647 1891:Mozavaptan 1886:Lixivaptan 1876:Conivaptan 1777:Nelivaptan 1683:WAY-267464 1628:Conivaptan 1623:Balovaptan 1497:WAY-162720 1492:SSR-126768 1447:Cligosiban 1412:WAY-267464 1365:Nacartocin 1345:Cargutocin 1340:Carbetocin 1335:Aspartocin 1313:modulators 1069:amphibian 1006:Spinorphin 996:Nociceptin 979:Amidorphin 917:Endorphins 874:Leumorphin 841:Dynorphins 412:Fatty acid 205:References 124:supraoptic 1965:YM-222546 1906:Tolvaptan 1841:Lypressin 1823:Agonists: 1732:Lypressin 1719:Agonists: 1658:PF-184563 1653:LY-307174 1633:FR-218944 1583:Lypressin 1575:Agonists: 1545:Puromycin 1530:Leupeptin 1507:Amastatin 1487:Retosiban 1482:Nolasiban 1477:L-372,662 1472:L-371,257 1467:L-368,899 1457:Erlosiban 1452:Epelsiban 1442:Barusiban 1360:Merotocin 1329:Agonists: 1180:FMRFamide 1165:Carnosine 1049:: mammal 1011:Valorphin 1001:Opiorphin 984:Hemorphin 707:Rhodopsin 152:Structure 139:disulfide 49:from the 1960:VMAX-382 1955:VMAX-372 1950:VMAX-367 1925:Unsorted 1916:YM-35471 1851:TC OT 39 1802:TASP-699 1799:Ligands: 1698:YM-35471 1678:TC OT 39 1618:Atosiban 1430:Atosiban 1427:Peptide: 1407:TC OT 39 1370:Oxytocin 1332:Peptide: 1321:Oxytocin 1306:Oxytocin 1155:Bombesin 1073:Kassinin 823:hormones 816:Hormones 805:Peptides 400:Proteins 193:See also 158:cysteine 102:Oxytocin 67:covalent 39:oxytocin 36:hormones 1980:Lithium 1836:LIT-001 1767:ABT-558 1762:ABT-436 1648:LIT-001 1402:LIT-001 1255:RVD-Hpα 1200:Ghrelin 1185:Galanin 1121:Orexins 674:Pigment 630:Vitamin 580:calcium 459:Hormone 342:7204368 166:proline 162:glycine 143:insulin 57:of the 45:to the 1998:Others 1911:YM-471 1693:YM-471 1688:YM-218 1673:SRX251 1668:SRX246 1417:WJ0679 1034:Kinins 967:Others 597:copper 515:IGFBP7 510:IGFBP6 505:IGFBP5 500:IGFBP4 495:IGFBP3 490:IGFBP2 485:IGFBP1 365:(MeSH) 340:  301:382985 299:  266:382985 264:  226:: 1–9. 164:, and 2040:This 1462:IX-01 1143:Other 1024:Other 716:Other 450:FABP7 445:FABP6 440:FABP5 435:FABP4 430:FABP3 425:FABP2 420:FABP1 2046:stub 1517:EDTA 1385:TGOT 1308:and 821:see 609:iron 338:PMID 297:PMID 262:PMID 137:The 126:and 53:and 41:and 30:are 1397:CA7 1260:VGF 856:1–8 328:doi 324:256 289:doi 254:doi 134:. 2091:: 2016:II 2014:, 1710:1B 1566:1A 1437:; 1392:; 807:: 543:: 532:II 468:: 402:: 336:. 322:. 318:. 295:. 285:48 283:. 260:. 250:48 248:. 232:^ 222:. 160:, 109:- 100:- 90:. 82:. 2077:e 2070:t 2063:v 2052:. 2018:) 2012:I 2010:( 1986:) 1982:( 1814:2 1812:V 1708:V 1564:V 1523:L 1298:e 1291:t 1284:v 1134:B 1129:A 1111:U 1106:S 1101:N 1096:B 797:e 790:t 783:v 657:4 652:3 647:2 642:1 547:/ 392:e 385:t 378:v 344:. 330:: 303:. 291:: 268:. 256:: 20:)

Index

Neurophysin
carrier proteins
hormones
oxytocin
vasopressin
posterior pituitary
paraventricular
supraoptic nucleus
hypothalamus
neurosecretory
covalent
posterior pituitary gland
proteolytic
circulatory system
glycopeptide
Neurophysin I
Oxytocin
Neurophysin II
Vasopressin
supraoptic
paraventricular
hypothalamus
disulfide
insulin
cysteine
glycine
proline
polypeptide chain

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