330:
307:
204:
229:
3370:
3355:
581:
595:
588:
3340:
336:
235:
29:
1825:-suppressed gene, upregulated during the adaptive response of prostate tumors to androgen-targeted therapies and a prognostic biomarker of clinical metastasis and lethal PCa. In vitro and in vivo mouse studies have shown membrane bound NRP1 to be proangiogenic and that NRP1 promotes the vascularization of prostate tumors.
2114:
Cantuti-Castelvetri, Ludovico; Ojha, Ravi; Pedro, Liliana D.; Djannatian, Minou; Franz, Jonas; Kuivanen, Suvi; Meer, Franziska van der; Kallio, Katri; Kaya, Tuğberk; Anastasina, Maria; Smura, Teemu; Levanov, Lev; Szirovicza, Leonora; Tobi, Allan; Kallio-Kokko, Hannimari; Österlund, Pamela; Joensuu,
2193:
Tse BW, Volpert M, Ratther E, Stylianou N, Nouri M, McGowan K, Lehman ML, McPherson SJ, Roshan-Moniri M, Butler MS, Caradec J, Gregory-Evans CY, McGovern J, Das R, Takhar M, Erho N, Alshalafa M, Davicioni E, Schaeffer EM, Jenkins RB, Ross AE, Karnes RJ, Den RB, Fazli L, Gregory PA, Gleave ME,
55:
2115:
Merja; Meunier, Frédéric A.; Butcher, Sarah J.; Winkler, Martin
Sebastian; Mollenhauer, Brit; Helenius, Ari; Gokce, Ozgun; Teesalu, Tambet; Hepojoki, Jussi; Vapalahti, Olli; Stadelmann, Christine; Balistreri, Giuseppe; Simons, Mikael (13 November 2020).
1809:
and progression of cancers. NRP1 expression has been shown to be elevated in a number of human patient tumor samples, including brain, prostate, breast, colon, and lung cancers and NRP1 levels are positively correlated with
2341:
Bachelder RE, Crago A, Chung J, Wendt MA, Shaw LM, Robinson G, Mercurio AM (August 2001). "Vascular endothelial growth factor is an autocrine survival factor for neuropilin-expressing breast carcinoma cells".
1852:
in tumor cells with elevated NRP1 expression. A patent for EG3287 was filed in 2002 and approved in 2003. As of 2015 there were no clinical trials ongoing or completed for EG3287 as a human cancer therapy.
3153:
Rossignol M, Gagnon ML, Klagsbrun M (December 2000). "Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms".
3260:
Walter JW, North PE, Waner M, Mizeracki A, Blei F, Walker JW, Reinisch JF, Marchuk DA (March 2002). "Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma".
1848:, NRP1 is a potential target for cancer therapies. A synthetic peptide, EG3287, was generated in 2005 and has been shown to block NRP1 activity. EG3287 has been shown to induce
3227:"Vascular endothelial growth factor receptor-2 and neuropilin-1 form a receptor complex that is responsible for the differential signaling potency of VEGF(165) and VEGF(121)"
1856:
Soluble NRP1 has the opposite effect of membrane bound NRP1 and has anti-VEGF activity. In vivo mouse studies have shown that injections of sNRP-1 inhibits progression of
3369:
3354:
2903:"Cloning and characterization of neuropilin-1-interacting protein: a PSD-95/Dlg/ZO-1 domain-containing protein that interacts with the cytoplasmic domain of neuropilin-1"
2800:
Takahashi T, Nakamura F, Jin Z, Kalb RG, Strittmatter SM (October 1998). "Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors".
2196:"Neuropilin-1 is upregulated in the adaptive response of prostate tumors to androgen-targeted therapies and is prognostic of metastatic progression and patient mortality"
343:
242:
1794:
1388:
1369:
165:
2987:
Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, Tessier-Lavigne M, Comoglio PM (October 1999).
3339:
3398:
3319:
1937:
2009:"Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III"
1919:
3032:"Identification of a natural soluble neuropilin-1 that binds vascular endothelial growth factor: In vivo expression and antitumor activity"
2582:"Identification of a natural soluble neuropilin-1 that binds vascular endothelial growth factor: In vivo expression and antitumor activity"
1782:
52:
2516:"A peptide corresponding to the neuropilin-1-binding site on VEGF(165) induces apoptosis of neuropilin-1-expressing breast tumour cells"
2310:
2293:
329:
1845:
1742:
1651:
1644:
2837:
Rossignol M, Beggs AH, Pierce EA, Klagsbrun M (May 1999). "Human neuropilin-1 and neuropilin-2 map to 10p12 and 2q34, respectively".
306:
2059:
1960:"Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor"
1906:
1885:
3085:"Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165 [corrected]"
228:
203:
1902:
2172:
2369:
Parikh AA, Fan F, Liu WB, Ahmad SA, Stoeltzing O, Reinmuth N, Bielenberg D, Bucana CD, Klagsbrun M, Ellis LM (June 2004).
1881:
145:
2724:"Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity"
2075:"Neuropilin-1 binds vascular endothelial growth factor 165, placenta growth factor-2, and heparin via its b1b2 domain"
1778:
2421:
Hong TM, Chen YL, Wu YY, Yuan A, Chao YC, Chung YC, Wu MH, Yang SC, Pan SH, Shih JY, Chan WK, Yang PC (August 2007).
342:
241:
2245:"Selective upregulation of vascular endothelial growth factor receptors neuropilin-1 and -2 in human neuroblastoma"
1829:
2989:"Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates"
3312:
2646:"Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family"
2294:"VEGF overexpression in clinically localized prostate tumors and neuropilin-1 overexpression in metastatic forms"
335:
234:
2944:
Takahashi T, Fournier A, Nakamura F, Wang LH, Murakami Y, Kalb RG, Fujisawa H, Strittmatter SM (October 1999).
2514:
Barr MP, Byrne AM, Duffy AM, Condron CM, Devocelle M, Harriott P, Bouchier-Hayes DJ, Harmey JH (January 2005).
1738:
1433:
153:
2868:"Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1"
2243:
Fakhari M, Pullirsch D, Abraham D, Paya K, Hofbauer R, Holzfeind P, Hofmann M, Aharinejad S (January 2002).
1414:
2194:
Williams ED, Rennie PS, Buttyan R, Gunter JH, Selth LA, Russell PJ, Nelson CC, Hollier BG (January 2017).
1857:
217:
2866:
Makinen T, Olofsson B, Karpanen T, Hellman U, Soker S, Klagsbrun M, Eriksson U, Alitalo K (July 1999).
3305:
3043:
2593:
2128:
132:
2767:"Semaphorin-neuropilin interactions underlying sympathetic axon responses to class III semaphorins"
2371:"Neuropilin-1 in human colon cancer: expression, regulation, and role in induction of angiogenesis"
1627:
1623:
1588:
1584:
1580:
1576:
1572:
1552:
1548:
1523:
1509:
1505:
1501:
1497:
3285:
3184:"Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing"
3018:
2975:
2825:
2753:
2710:
2493:
2323:
2274:
2038:
1989:
177:
3120:"The interaction of neuropilin-1 with vascular endothelial growth factor and its receptor flt-1"
1619:
1598:
1544:
1513:
3030:
Gagnon ML, Bielenberg DR, Gechtman Z, Miao HQ, Takashima S, Soker S, Klagsbrun M (March 2000).
2580:
Gagnon ML, Bielenberg DR, Gechtman Z, Miao HQ, Takashima S, Soker S, Klagsbrun M (March 2000).
3403:
3277:
3248:
3213:
3170:
3141:
3106:
3071:
3010:
2967:
2932:
2889:
2854:
2817:
2788:
2745:
2702:
2667:
2621:
2545:
2485:
2444:
2400:
2351:
2315:
2266:
2225:
2154:
2096:
2030:
1981:
125:
45:
3269:
3238:
3203:
3195:
3162:
3131:
3096:
3061:
3051:
3000:
2957:
2922:
2914:
2879:
2846:
2809:
2778:
2735:
2692:
2657:
2611:
2601:
2535:
2527:
2475:
2434:
2390:
2382:
2305:
2256:
2215:
2207:
2144:
2136:
2086:
2020:
1971:
1718:
580:
422:
353:
297:
252:
2722:
Giger RJ, Urquhart ER, Gillespie SK, Levengood DV, Ginty DD, Kolodkin AL (November 1998).
1818:
594:
587:
397:
173:
3047:
2597:
2292:
Latil A, Bièche I, Pesche S, Valéri A, Fournier G, Cussenot O, Lidereau R (March 2000).
2132:
3208:
3183:
2927:
2918:
2902:
2540:
2515:
2395:
2370:
2220:
2195:
2149:
2116:
1766:
3005:
2988:
2962:
2945:
2783:
2766:
2740:
2723:
2697:
2680:
2662:
2645:
2563:
2386:
2025:
2008:
1976:
1959:
1303:
1298:
1293:
1288:
1283:
1278:
1273:
1268:
1263:
1258:
1253:
1248:
1243:
1238:
1233:
1228:
1223:
1218:
1213:
1208:
1203:
1198:
1193:
1188:
1183:
1178:
1173:
1168:
1163:
1158:
1153:
1148:
1143:
1138:
1133:
1128:
1123:
1118:
1113:
1108:
1103:
1098:
1093:
1088:
1083:
1078:
1073:
1068:
1063:
1058:
1053:
1048:
1043:
1038:
1033:
1028:
1023:
1018:
1013:
1008:
1003:
998:
993:
988:
983:
978:
973:
968:
963:
958:
953:
948:
943:
938:
933:
928:
923:
918:
913:
908:
903:
898:
893:
888:
883:
878:
873:
868:
863:
858:
853:
848:
843:
838:
833:
828:
823:
818:
813:
797:
792:
787:
782:
777:
772:
767:
762:
757:
752:
747:
742:
737:
732:
727:
722:
717:
712:
707:
702:
686:
681:
676:
671:
666:
661:
656:
651:
646:
641:
636:
28:
3392:
3066:
3031:
2616:
2581:
1762:
623:
3289:
3022:
2979:
2829:
2757:
2464:"Neuropilin-1 expression by tumor cells promotes tumor angiogenesis and progression"
2278:
2073:
Mamluk R, Gechtman Z, Kutcher ME, Gasiunas N, Gallagher J, Klagsbrun M (July 2002).
2042:
3378:: Structural Basis for Ligand Binding and Heparin Mediated Activation of Neuropilin
3363:: Structural Basis for Ligand Binding and Heparin Mediated Activation of Neuropilin
2714:
2497:
2327:
1806:
1758:
415:
194:
157:
3199:
2439:
2422:
1993:
3182:
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (September 2000).
181:
1942:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1924:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1841:
3036:
Proceedings of the
National Academy of Sciences of the United States of America
2586:
Proceedings of the
National Academy of Sciences of the United States of America
498:
1811:
1750:
1734:
1722:
1149:
dichotomous subdivision of terminal units involved in salivary gland branching
314:
211:
161:
2884:
2867:
2140:
1849:
1333:
1134:
neural crest cell migration involved in autonomic nervous system development
558:
436:
381:
368:
280:
267:
169:
3281:
3252:
3243:
3226:
3217:
3174:
3166:
3145:
3136:
3119:
3110:
3101:
3084:
3075:
3056:
3014:
2971:
2936:
2893:
2858:
2850:
2821:
2671:
2625:
2606:
2549:
2531:
2489:
2448:
2404:
2355:
2319:
2311:
10.1002/(SICI)1097-0215(20000320)89:2<167::AID-IJC11>3.0.CO;2-9
2270:
2229:
2158:
2100:
2091:
2074:
2792:
2749:
2706:
2480:
2463:
2034:
2007:
Chen H, Chédotal A, He Z, Goodman CS, Tessier-Lavigne M (September 1997).
1985:
1691:
1686:
1014:
semaphorin-plexin signaling pathway involved in neuron projection guidance
2211:
1822:
1675:
1478:
1459:
1279:
positive regulation of cell migration involved in sprouting angiogenesis
2946:"Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors"
2681:"Neuropilin is a receptor for the axonal chemorepellent Semaphorin III"
2261:
2244:
1707:
1445:
1400:
3273:
2173:"Neuropilin-1 drives SARS-CoV-2 infectivity, finds breakthrough study"
1054:
gonadotrophin-releasing hormone neuronal migration to the hypothalamus
102:
98:
94:
90:
86:
82:
78:
74:
1828:
Elevated NRP1 expression is also correlated with the invasiveness of
1754:
1659:
1355:
829:
VEGF-activated neuropilin signaling pathway involved in axon guidance
1958:
Soker S, Takashima S, Miao HQ, Neufeld G, Klagsbrun M (March 1998).
1797:
into cells, making it a possible target for future antiviral drugs.
1746:
1284:
positive regulation of substrate adhesion-dependent cell spreading
2813:
1318:
1314:
2423:"Targeting neuropilin 1 as an antitumor strategy in lung cancer"
2117:"Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity"
1714:
1154:
cellular response to vascular endothelial growth factor stimulus
149:
3301:
1114:
positive regulation of axon extension involved in axon guidance
934:
negative regulation of axon extension involved in axon guidance
603:
3297:
3083:
Gluzman-Poltorak Z, Cohen T, Herzog Y, Neufeld G (June 2000).
667:
vascular endothelial growth factor-activated receptor activity
2462:
Miao HQ, Lee P, Lin H, Soker S, Klagsbrun M (December 2000).
864:
vascular endothelial growth factor receptor signaling pathway
844:
semaphorin-plexin signaling pathway involved in axon guidance
909:
negative regulation of extrinsic apoptotic signaling pathway
3348:: Crystal Structure of the b1 Domain of Human Neuropilin-1
2765:
Chen H, He Z, Bagri A, Tessier-Lavigne M (December 1998).
1793:
Research has shown that neuropilin 1 facilitates entry of
849:
positive regulation of retinal ganglion cell axon guidance
964:
platelet-derived growth factor receptor signaling pathway
1289:
positive regulation of actin cytoskeleton reorganization
954:
positive regulation of peptidyl-tyrosine phosphorylation
924:
angiogenesis involved in coronary vascular morphogenesis
405:
1019:
cellular response to hepatocyte growth factor stimulus
899:
regulation of axon extension involved in axon guidance
1079:
positive regulation of endothelial cell proliferation
570:
824:
vascular endothelial growth factor signaling pathway
3225:Whitaker GB, Limberg BJ, Rosenbaum JS (July 2001).
1612:
1571:
1537:
1496:
989:
retina vasculature morphogenesis in camera-type eye
979:
hepatocyte growth factor receptor signaling pathway
854:
positive regulation of smooth muscle cell migration
1898:
1896:
1894:
1877:
1875:
1873:
1204:substrate-dependent cell migration, cell extension
1717:. In humans, the neuropilin 1 gene is located at
1214:positive regulation of endothelial cell migration
1044:regulation of retinal ganglion cell axon guidance
839:cell migration involved in sprouting angiogenesis
352:
251:
2564:"Vegf peptides and their use (WO 2003082918 A1)"
1757:) family members. NRP1 plays versatile roles in
959:branching involved in blood vessel morphogenesis
136:, BDCA4, CD304, NP1, NRP, VEGF165R, Neuropilin 1
2188:
2186:
1224:regulation of Cdc42 protein signal transduction
1124:vestibulocochlear nerve structural organization
814:negative regulation of neuron apoptotic process
16:Protein-coding gene in the species Homo sapiens
3118:Fuh G, Garcia KC, de Vos AM (September 2000).
1903:GRCm38: Ensembl release 89: ENSMUSG00000025810
1274:positive regulation of focal adhesion assembly
3313:
1953:
1951:
8:
1269:positive regulation of stress fiber assembly
879:positive regulation of ERK1 and ERK2 cascade
1882:GRCh38: Ensembl release 89: ENSG00000099250
1239:VEGF-activated neuropilin signaling pathway
1229:substrate adhesion-dependent cell spreading
798:integral component of postsynaptic membrane
3320:
3306:
3298:
1568:
1493:
1329:
1264:positive regulation of filopodium assembly
642:vascular endothelial growth factor binding
619:
393:
292:
189:
63:
3242:
3207:
3135:
3100:
3065:
3055:
3004:
2961:
2926:
2883:
2782:
2739:
2696:
2661:
2615:
2605:
2539:
2509:
2507:
2479:
2438:
2394:
2309:
2260:
2219:
2148:
2090:
2024:
1975:
1074:ventral trunk neural crest cell migration
2054:
2052:
1805:Neuropilin 1 has been implicated in the
1109:positive regulation of cytokine activity
1099:regulation of vesicle-mediated transport
999:axon extension involved in axon guidance
894:trigeminal nerve structural organization
3335:
2679:He Z, Tessier-Lavigne M (August 1997).
2416:
2414:
1869:
1174:sympathetic neuron projection extension
1089:endothelial tip cell fate specification
529:cardiac muscle tissue of left ventricle
1254:positive regulation of GTPase activity
1244:positive regulation of phosphorylation
1084:sympathetic nervous system development
889:protein localization to early endosome
859:sympathetic neuron projection guidance
18:
1059:negative regulation of axon extension
357:
318:
313:
256:
215:
210:
7:
2644:Zachary I, Gliki G (February 2001).
1821:NRP1 has been demonstrated to be an
1783:Vascular endothelial growth factor A
1144:axonogenesis involved in innervation
974:facial nerve structural organization
3231:The Journal of Biological Chemistry
3124:The Journal of Biological Chemistry
3089:The Journal of Biological Chemistry
2872:The Journal of Biological Chemistry
2079:The Journal of Biological Chemistry
1259:positive regulation of angiogenesis
1209:integrin-mediated signaling pathway
1179:semaphorin-plexin signaling pathway
1064:retinal ganglion cell axon guidance
2919:10.1523/JNEUROSCI.19-15-06519.1999
1743:vascular endothelial growth factor
1609:
1534:
1469:
1450:
1424:
1405:
1379:
1360:
1199:outflow tract septum morphogenesis
1129:multicellular organism development
1049:branchiomotor neuron axon guidance
994:dorsal root ganglion morphogenesis
819:facioacoustic ganglion development
575:
493:
431:
410:
14:
2375:The American Journal of Pathology
1710:that in humans is encoded by the
1219:actin cytoskeleton reorganization
3368:
3353:
3338:
2060:"Entrez Gene: NRP1 neuropilin 1"
1004:sympathetic ganglion development
929:commissural neuron axon guidance
593:
586:
579:
341:
334:
328:
305:
240:
233:
227:
202:
27:
3262:Genes, Chromosomes & Cancer
2298:International Journal of Cancer
1777:Neuropilin 1 has been shown to
1104:trigeminal ganglion development
2901:Cai H, Reed RR (August 1999).
919:trigeminal nerve morphogenesis
733:integral component of membrane
604:More reference expression data
559:More reference expression data
1:
3006:10.1016/S0092-8674(00)80063-X
2963:10.1016/S0092-8674(00)80062-8
2784:10.1016/S0896-6273(00)80648-0
2741:10.1016/S0896-6273(00)80625-X
2698:10.1016/S0092-8674(00)80534-6
2663:10.1016/S0008-6363(00)00268-6
2440:10.1158/1078-0432.CCR-07-0001
2387:10.1016/s0002-9440(10)63772-8
2026:10.1016/S0896-6273(00)80371-2
1977:10.1016/S0092-8674(00)81402-6
904:coronary artery morphogenesis
326:
225:
3399:Genes on human chromosome 10
1234:neuropilin signaling pathway
869:sensory neuron axon guidance
652:semaphorin receptor activity
3200:10.1093/embo-reports/kvd058
2907:The Journal of Neuroscience
1836:Target for cancer therapies
1832:both in vitro and in vivo.
1721:. This is one of two human
1304:basal dendrite arborization
1139:endothelial cell chemotaxis
718:semaphorin receptor complex
479:subcutaneous adipose tissue
447:stromal cell of endometrium
3420:
1830:non-small cell lung cancer
1299:basal dendrite development
1249:endothelial cell migration
1159:motor neuron axon guidance
1069:renal artery morphogenesis
1039:nervous system development
884:animal organ morphogenesis
537:superior cervical ganglion
3333:
2520:British Journal of Cancer
1938:"Mouse PubMed Reference:"
1920:"Human PubMed Reference:"
1733:NRP1 is a membrane-bound
1690:
1685:
1681:
1674:
1658:
1652:Chr 8: 129.09 – 129.23 Mb
1639:
1616:
1595:
1564:
1541:
1520:
1489:
1476:
1472:
1457:
1453:
1444:
1431:
1427:
1412:
1408:
1399:
1386:
1382:
1367:
1363:
1354:
1339:
1332:
1328:
1312:
682:GTPase activator activity
622:
618:
601:
578:
569:
556:
505:
496:
443:
434:
404:
396:
392:
375:
362:
325:
304:
295:
291:
274:
261:
224:
201:
192:
188:
143:
140:
130:
123:
118:
71:
66:
49:
44:
39:
35:
26:
21:
2885:10.1074/jbc.274.30.21217
2427:Clinical Cancer Research
1739:tyrosine kinase receptor
1645:Chr 10: 33.18 – 33.34 Mb
1294:postsynapse organization
1189:otic placode development
2650:Cardiovascular Research
2141:10.1126/science.abd2985
513:external carotid artery
509:internal carotid artery
3244:10.1074/jbc.M102315200
3167:10.1006/geno.2000.6381
3137:10.1074/jbc.M003955200
3102:10.1074/jbc.M909259199
3057:10.1073/pnas.040337597
2851:10.1006/geno.1999.5790
2607:10.1073/pnas.040337597
2532:10.1038/sj.bjc.6602308
2092:10.1074/jbc.M200730200
1858:acute myeloid leukemia
1194:motor neuron migration
1029:sprouting angiogenesis
687:protein kinase binding
2481:10.1096/fj.00-0250com
1801:Implication in cancer
793:glutamatergic synapse
672:growth factor binding
517:stroma of bone marrow
218:Chromosome 10 (human)
2212:10.1038/onc.2016.482
1024:dendrite development
1009:cell differentiation
984:axonal fasciculation
949:artery morphogenesis
944:response to wounding
713:extracellular region
483:smooth muscle tissue
359:8 E2|8 75.78 cM
320:Chromosome 8 (mouse)
67:List of PDB id codes
40:Available structures
3048:2000PNAS...97.2573G
2802:Nature Neuroscience
2598:2000PNAS...97.2573G
2133:2020Sci...370..856C
1184:signal transduction
1094:cell-cell signaling
969:positive chemotaxis
778:extracellular space
773:cytoplasmic vesicle
657:coreceptor activity
533:trigeminal ganglion
467:epithelium of colon
2262:10.1002/cncr.10177
1434:ENSMUSG00000025810
914:neuron development
807:Biological process
758:neuronal cell body
696:Cellular component
630:Molecular function
3386:
3385:
3274:10.1002/gcc.10028
2206:(24): 3417–3427.
2127:(6518): 856–860.
1765:, cell survival,
1701:
1700:
1697:
1696:
1670:
1669:
1635:
1634:
1606:
1605:
1560:
1559:
1531:
1530:
1485:
1484:
1466:
1465:
1440:
1439:
1421:
1420:
1395:
1394:
1376:
1375:
1324:
1323:
1164:nerve development
939:heart development
788:neuron projection
662:metal ion binding
614:
613:
610:
609:
565:
564:
552:
551:
490:
489:
388:
387:
287:
286:
114:
113:
110:
109:
50:Ortholog search:
3411:
3372:
3357:
3342:
3322:
3315:
3308:
3299:
3293:
3256:
3246:
3237:(27): 25520–31.
3221:
3211:
3178:
3149:
3139:
3114:
3104:
3079:
3069:
3059:
3026:
3008:
2983:
2965:
2940:
2930:
2897:
2887:
2878:(30): 21217–22.
2862:
2833:
2796:
2786:
2761:
2743:
2718:
2700:
2675:
2665:
2630:
2629:
2619:
2609:
2577:
2571:
2570:
2568:
2560:
2554:
2553:
2543:
2511:
2502:
2501:
2483:
2459:
2453:
2452:
2442:
2418:
2409:
2408:
2398:
2366:
2360:
2359:
2338:
2332:
2331:
2313:
2289:
2283:
2282:
2264:
2240:
2234:
2233:
2223:
2190:
2181:
2180:
2169:
2163:
2162:
2152:
2111:
2105:
2104:
2094:
2085:(27): 24818–25.
2070:
2064:
2063:
2056:
2047:
2046:
2028:
2004:
1998:
1997:
1979:
1955:
1946:
1945:
1934:
1928:
1927:
1916:
1910:
1900:
1889:
1879:
1789:Role in COVID-19
1769:, and invasion.
1683:
1682:
1654:
1647:
1630:
1610:
1601:
1569:
1565:RefSeq (protein)
1555:
1535:
1526:
1494:
1470:
1451:
1425:
1406:
1380:
1361:
1330:
1034:neuron migration
743:receptor complex
728:sorting endosome
647:cytokine binding
620:
606:
597:
590:
583:
576:
561:
501:
499:Top expressed in
494:
439:
437:Top expressed in
432:
411:
394:
384:
371:
360:
345:
338:
332:
321:
309:
293:
283:
270:
259:
244:
237:
231:
220:
206:
190:
184:
182:NRP1 - orthologs
135:
128:
105:
64:
58:
37:
36:
31:
19:
3419:
3418:
3414:
3413:
3412:
3410:
3409:
3408:
3389:
3388:
3387:
3382:
3379:
3373:
3364:
3358:
3349:
3343:
3329:
3326:
3296:
3259:
3224:
3181:
3152:
3130:(35): 26690–5.
3117:
3095:(24): 18040–5.
3082:
3029:
2986:
2943:
2913:(15): 6519–27.
2900:
2865:
2836:
2799:
2764:
2721:
2678:
2643:
2639:
2637:Further reading
2634:
2633:
2579:
2578:
2574:
2566:
2562:
2561:
2557:
2513:
2512:
2505:
2461:
2460:
2456:
2433:(16): 4759–68.
2420:
2419:
2412:
2368:
2367:
2363:
2350:(15): 5736–40.
2344:Cancer Research
2340:
2339:
2335:
2291:
2290:
2286:
2242:
2241:
2237:
2192:
2191:
2184:
2171:
2170:
2166:
2113:
2112:
2108:
2072:
2071:
2067:
2058:
2057:
2050:
2006:
2005:
2001:
1957:
1956:
1949:
1936:
1935:
1931:
1918:
1917:
1913:
1901:
1892:
1880:
1871:
1866:
1838:
1819:prostate cancer
1807:vascularization
1803:
1791:
1775:
1731:
1692:View/Edit Mouse
1687:View/Edit Human
1650:
1643:
1640:Location (UCSC)
1626:
1622:
1618:
1597:
1591:
1587:
1583:
1579:
1575:
1551:
1547:
1543:
1522:
1516:
1512:
1508:
1504:
1500:
1415:ENSG00000099250
1308:
834:toxin transport
802:
748:plasma membrane
691:
677:protein binding
637:heparin binding
602:
592:
591:
585:
584:
557:
548:
543:
539:
535:
531:
527:
525:renal corpuscle
523:
519:
515:
511:
497:
486:
481:
477:
473:
469:
465:
463:right ventricle
461:
457:
455:Achilles tendon
453:
449:
435:
379:
366:
358:
348:
347:
346:
339:
319:
296:Gene location (
278:
265:
257:
247:
246:
245:
238:
216:
193:Gene location (
144:
131:
124:
73:
51:
17:
12:
11:
5:
3417:
3415:
3407:
3406:
3401:
3391:
3390:
3384:
3383:
3381:
3380:
3374:
3367:
3365:
3359:
3352:
3350:
3344:
3337:
3334:
3331:
3330:
3327:
3325:
3324:
3317:
3310:
3302:
3295:
3294:
3268:(3): 295–303.
3257:
3222:
3179:
3150:
3115:
3080:
3027:
2984:
2941:
2898:
2863:
2834:
2797:
2777:(6): 1283–90.
2762:
2734:(5): 1079–92.
2719:
2676:
2640:
2638:
2635:
2632:
2631:
2572:
2569:. Oct 9, 2003.
2555:
2503:
2474:(15): 2532–9.
2454:
2410:
2381:(6): 2139–51.
2361:
2333:
2284:
2235:
2182:
2164:
2106:
2065:
2048:
1999:
1947:
1929:
1911:
1890:
1868:
1867:
1865:
1862:
1837:
1834:
1802:
1799:
1790:
1787:
1774:
1771:
1753:(for example,
1745:(for example,
1730:
1727:
1699:
1698:
1695:
1694:
1689:
1679:
1678:
1672:
1671:
1668:
1667:
1665:
1663:
1656:
1655:
1648:
1641:
1637:
1636:
1633:
1632:
1614:
1613:
1607:
1604:
1603:
1593:
1592:
1566:
1562:
1561:
1558:
1557:
1539:
1538:
1532:
1529:
1528:
1518:
1517:
1491:
1487:
1486:
1483:
1482:
1474:
1473:
1467:
1464:
1463:
1455:
1454:
1448:
1442:
1441:
1438:
1437:
1429:
1428:
1422:
1419:
1418:
1410:
1409:
1403:
1397:
1396:
1393:
1392:
1384:
1383:
1377:
1374:
1373:
1365:
1364:
1358:
1352:
1351:
1346:
1341:
1337:
1336:
1326:
1325:
1322:
1321:
1310:
1309:
1307:
1306:
1301:
1296:
1291:
1286:
1281:
1276:
1271:
1266:
1261:
1256:
1251:
1246:
1241:
1236:
1231:
1226:
1221:
1216:
1211:
1206:
1201:
1196:
1191:
1186:
1181:
1176:
1171:
1169:cell migration
1166:
1161:
1156:
1151:
1146:
1141:
1136:
1131:
1126:
1121:
1116:
1111:
1106:
1101:
1096:
1091:
1086:
1081:
1076:
1071:
1066:
1061:
1056:
1051:
1046:
1041:
1036:
1031:
1026:
1021:
1016:
1011:
1006:
1001:
996:
991:
986:
981:
976:
971:
966:
961:
956:
951:
946:
941:
936:
931:
926:
921:
916:
911:
906:
901:
896:
891:
886:
881:
876:
871:
866:
861:
856:
851:
846:
841:
836:
831:
826:
821:
816:
810:
808:
804:
803:
801:
800:
795:
790:
785:
783:focal adhesion
780:
775:
770:
765:
763:early endosome
760:
755:
750:
745:
740:
735:
730:
725:
720:
715:
710:
705:
699:
697:
693:
692:
690:
689:
684:
679:
674:
669:
664:
659:
654:
649:
644:
639:
633:
631:
627:
626:
616:
615:
612:
611:
608:
607:
599:
598:
573:
567:
566:
563:
562:
554:
553:
550:
549:
547:
546:
542:
541:left lung lobe
538:
534:
530:
526:
522:
518:
514:
510:
506:
503:
502:
491:
488:
487:
485:
484:
480:
476:
475:left ventricle
472:
468:
464:
460:
459:synovial joint
456:
452:
448:
444:
441:
440:
428:
427:
419:
408:
402:
401:
398:RNA expression
390:
389:
386:
385:
377:
373:
372:
364:
361:
356:
350:
349:
340:
333:
327:
323:
322:
317:
311:
310:
302:
301:
289:
288:
285:
284:
276:
272:
271:
263:
260:
255:
249:
248:
239:
232:
226:
222:
221:
214:
208:
207:
199:
198:
186:
185:
142:
138:
137:
129:
121:
120:
116:
115:
112:
111:
108:
107:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
3416:
3405:
3402:
3400:
3397:
3396:
3394:
3377:
3371:
3366:
3362:
3356:
3351:
3347:
3341:
3336:
3332:
3323:
3318:
3316:
3311:
3309:
3304:
3303:
3300:
3291:
3287:
3283:
3279:
3275:
3271:
3267:
3263:
3258:
3254:
3250:
3245:
3240:
3236:
3232:
3228:
3223:
3219:
3215:
3210:
3205:
3201:
3197:
3194:(3): 287–92.
3193:
3189:
3185:
3180:
3176:
3172:
3168:
3164:
3161:(2): 211–22.
3160:
3156:
3151:
3147:
3143:
3138:
3133:
3129:
3125:
3121:
3116:
3112:
3108:
3103:
3098:
3094:
3090:
3086:
3081:
3077:
3073:
3068:
3063:
3058:
3053:
3049:
3045:
3042:(6): 2573–8.
3041:
3037:
3033:
3028:
3024:
3020:
3016:
3012:
3007:
3002:
2998:
2994:
2990:
2985:
2981:
2977:
2973:
2969:
2964:
2959:
2955:
2951:
2947:
2942:
2938:
2934:
2929:
2924:
2920:
2916:
2912:
2908:
2904:
2899:
2895:
2891:
2886:
2881:
2877:
2873:
2869:
2864:
2860:
2856:
2852:
2848:
2845:(3): 459–60.
2844:
2840:
2835:
2831:
2827:
2823:
2819:
2815:
2811:
2808:(6): 487–93.
2807:
2803:
2798:
2794:
2790:
2785:
2780:
2776:
2772:
2768:
2763:
2759:
2755:
2751:
2747:
2742:
2737:
2733:
2729:
2725:
2720:
2716:
2712:
2708:
2704:
2699:
2694:
2691:(4): 739–51.
2690:
2686:
2682:
2677:
2673:
2669:
2664:
2659:
2656:(3): 568–81.
2655:
2651:
2647:
2642:
2641:
2636:
2627:
2623:
2618:
2613:
2608:
2603:
2599:
2595:
2592:(6): 2573–8.
2591:
2587:
2583:
2576:
2573:
2565:
2559:
2556:
2551:
2547:
2542:
2537:
2533:
2529:
2526:(2): 328–33.
2525:
2521:
2517:
2510:
2508:
2504:
2499:
2495:
2491:
2487:
2482:
2477:
2473:
2469:
2468:FASEB Journal
2465:
2458:
2455:
2450:
2446:
2441:
2436:
2432:
2428:
2424:
2417:
2415:
2411:
2406:
2402:
2397:
2392:
2388:
2384:
2380:
2376:
2372:
2365:
2362:
2357:
2353:
2349:
2345:
2337:
2334:
2329:
2325:
2321:
2317:
2312:
2307:
2304:(2): 167–71.
2303:
2299:
2295:
2288:
2285:
2280:
2276:
2272:
2268:
2263:
2258:
2255:(1): 258–63.
2254:
2250:
2246:
2239:
2236:
2231:
2227:
2222:
2217:
2213:
2209:
2205:
2201:
2197:
2189:
2187:
2183:
2178:
2177:MedicalXpress
2174:
2168:
2165:
2160:
2156:
2151:
2146:
2142:
2138:
2134:
2130:
2126:
2122:
2118:
2110:
2107:
2102:
2098:
2093:
2088:
2084:
2080:
2076:
2069:
2066:
2061:
2055:
2053:
2049:
2044:
2040:
2036:
2032:
2027:
2022:
2019:(3): 547–59.
2018:
2014:
2010:
2003:
2000:
1995:
1991:
1987:
1983:
1978:
1973:
1970:(6): 735–45.
1969:
1965:
1961:
1954:
1952:
1948:
1943:
1939:
1933:
1930:
1925:
1921:
1915:
1912:
1908:
1904:
1899:
1897:
1895:
1891:
1887:
1883:
1878:
1876:
1874:
1870:
1863:
1861:
1859:
1854:
1851:
1847:
1843:
1835:
1833:
1831:
1826:
1824:
1820:
1815:
1813:
1808:
1800:
1798:
1796:
1788:
1786:
1784:
1780:
1772:
1770:
1768:
1764:
1763:axon guidance
1760:
1756:
1752:
1748:
1744:
1740:
1736:
1728:
1726:
1724:
1720:
1716:
1713:
1709:
1705:
1693:
1688:
1684:
1680:
1677:
1673:
1666:
1664:
1661:
1657:
1653:
1649:
1646:
1642:
1638:
1631:
1629:
1625:
1621:
1615:
1611:
1608:
1602:
1600:
1594:
1590:
1586:
1582:
1578:
1574:
1570:
1567:
1563:
1556:
1554:
1550:
1546:
1540:
1536:
1533:
1527:
1525:
1519:
1515:
1511:
1507:
1503:
1499:
1495:
1492:
1490:RefSeq (mRNA)
1488:
1481:
1480:
1475:
1471:
1468:
1462:
1461:
1456:
1452:
1449:
1447:
1443:
1436:
1435:
1430:
1426:
1423:
1417:
1416:
1411:
1407:
1404:
1402:
1398:
1391:
1390:
1385:
1381:
1378:
1372:
1371:
1366:
1362:
1359:
1357:
1353:
1350:
1347:
1345:
1342:
1338:
1335:
1331:
1327:
1320:
1316:
1311:
1305:
1302:
1300:
1297:
1295:
1292:
1290:
1287:
1285:
1282:
1280:
1277:
1275:
1272:
1270:
1267:
1265:
1262:
1260:
1257:
1255:
1252:
1250:
1247:
1245:
1242:
1240:
1237:
1235:
1232:
1230:
1227:
1225:
1222:
1220:
1217:
1215:
1212:
1210:
1207:
1205:
1202:
1200:
1197:
1195:
1192:
1190:
1187:
1185:
1182:
1180:
1177:
1175:
1172:
1170:
1167:
1165:
1162:
1160:
1157:
1155:
1152:
1150:
1147:
1145:
1142:
1140:
1137:
1135:
1132:
1130:
1127:
1125:
1122:
1120:
1119:axon guidance
1117:
1115:
1112:
1110:
1107:
1105:
1102:
1100:
1097:
1095:
1092:
1090:
1087:
1085:
1082:
1080:
1077:
1075:
1072:
1070:
1067:
1065:
1062:
1060:
1057:
1055:
1052:
1050:
1047:
1045:
1042:
1040:
1037:
1035:
1032:
1030:
1027:
1025:
1022:
1020:
1017:
1015:
1012:
1010:
1007:
1005:
1002:
1000:
997:
995:
992:
990:
987:
985:
982:
980:
977:
975:
972:
970:
967:
965:
962:
960:
957:
955:
952:
950:
947:
945:
942:
940:
937:
935:
932:
930:
927:
925:
922:
920:
917:
915:
912:
910:
907:
905:
902:
900:
897:
895:
892:
890:
887:
885:
882:
880:
877:
875:
872:
870:
867:
865:
862:
860:
857:
855:
852:
850:
847:
845:
842:
840:
837:
835:
832:
830:
827:
825:
822:
820:
817:
815:
812:
811:
809:
806:
805:
799:
796:
794:
791:
789:
786:
784:
781:
779:
776:
774:
771:
769:
768:neurofilament
766:
764:
761:
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629:
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624:Gene ontology
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582:
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34:
30:
25:
20:
3375:
3360:
3345:
3265:
3261:
3234:
3230:
3191:
3188:EMBO Reports
3187:
3158:
3154:
3127:
3123:
3092:
3088:
3039:
3035:
2999:(1): 71–80.
2996:
2992:
2956:(1): 59–69.
2953:
2949:
2910:
2906:
2875:
2871:
2842:
2838:
2814:10.1038/2203
2805:
2801:
2774:
2770:
2731:
2727:
2688:
2684:
2653:
2649:
2589:
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2575:
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2430:
2426:
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2238:
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2199:
2176:
2167:
2124:
2120:
2109:
2082:
2078:
2068:
2016:
2012:
2002:
1967:
1963:
1941:
1932:
1923:
1914:
1855:
1839:
1827:
1816:
1804:
1792:
1776:
1773:Interactions
1759:angiogenesis
1732:
1711:
1704:Neuropilin-1
1703:
1702:
1628:NP_001345889
1624:NP_001345888
1617:
1596:
1589:NP_001316997
1585:NP_001231902
1581:NP_001231901
1577:NP_001019800
1573:NP_001019799
1553:NM_001358960
1549:NM_001358959
1542:
1524:NM_001330068
1521:
1510:NM_001244973
1506:NM_001244972
1502:NM_001024629
1498:NM_001024628
1477:
1458:
1432:
1413:
1387:
1368:
1348:
1343:
874:angiogenesis
723:cell surface
545:carotid body
421:
414:
380:129,229,844
367:129,085,085
141:External IDs
72:
3328:PDB gallery
1842:co-receptor
1723:neuropilins
738:growth cone
471:gallbladder
451:pericardium
279:33,336,262
266:33,177,492
119:Identifiers
3393:Categories
1909:, May 2017
1888:, May 2017
1864:References
1812:metastasis
1795:SARS-CoV-2
1751:semaphorin
1735:coreceptor
425:(ortholog)
162:HomoloGene
1860:in mice.
1850:apoptosis
1767:migration
1741:for both
1620:NP_032763
1599:NP_003864
1545:NM_008737
1514:NM_003873
1334:Orthologs
521:left lung
170:GeneCards
3404:Proteins
3290:33428561
3282:11807987
3253:11333271
3218:11256614
3175:11112349
3155:Genomics
3146:10842181
3111:10748121
3076:10688880
3023:17386412
3015:10520995
2980:18167425
2972:10520994
2937:10414980
2894:10409677
2859:10329017
2839:Genomics
2830:38320889
2822:10196546
2758:18445456
2672:11166270
2626:10688880
2567:(patent)
2550:15655556
2490:11099472
2449:17699853
2405:15161648
2356:11479209
2320:10754495
2279:45773136
2271:11815985
2230:28092670
2200:Oncogene
2159:33082293
2101:11986311
2043:17985062
1905:–
1884:–
1823:androgen
1779:interact
1729:Function
1719:10p11.22
1676:Wikidata
1313:Sources:
708:membrane
258:10p11.22
3209:1083732
3044:Bibcode
2928:6782790
2793:9883722
2750:9856463
2715:9720408
2707:9288753
2594:Bibcode
2541:2361857
2498:2370002
2396:1615754
2328:7393385
2221:5485179
2150:7857391
2129:Bibcode
2121:Science
2035:9331348
1986:9529250
1907:Ensembl
1886:Ensembl
1708:protein
1446:UniProt
1401:Ensembl
1340:Species
1319:QuickGO
703:cytosol
400:pattern
126:Aliases
3288:
3280:
3251:
3216:
3206:
3173:
3144:
3109:
3074:
3064:
3021:
3013:
2978:
2970:
2935:
2925:
2892:
2857:
2828:
2820:
2791:
2771:Neuron
2756:
2748:
2728:Neuron
2713:
2705:
2670:
2624:
2614:
2548:
2538:
2496:
2488:
2447:
2403:
2393:
2354:
2326:
2318:
2277:
2269:
2249:Cancer
2228:
2218:
2157:
2147:
2099:
2041:
2033:
2013:Neuron
1994:547080
1992:
1984:
1755:SEMA3A
1749:) and
1662:search
1660:PubMed
1479:P97333
1460:O14786
1356:Entrez
571:BioGPS
158:106206
150:602069
3286:S2CID
3067:15970
3019:S2CID
2976:S2CID
2826:S2CID
2754:S2CID
2711:S2CID
2617:15970
2494:S2CID
2324:S2CID
2275:S2CID
2039:S2CID
1990:S2CID
1840:As a
1781:with
1747:VEGFA
1737:to a
1706:is a
1389:18186
1349:Mouse
1344:Human
1315:Amigo
423:Mouse
416:Human
363:Start
298:Mouse
262:Start
195:Human
3376:2orz
3361:2orx
3346:1kex
3278:PMID
3249:PMID
3214:PMID
3171:PMID
3142:PMID
3107:PMID
3072:PMID
3011:PMID
2993:Cell
2968:PMID
2950:Cell
2933:PMID
2890:PMID
2855:PMID
2818:PMID
2789:PMID
2746:PMID
2703:PMID
2685:Cell
2668:PMID
2622:PMID
2546:PMID
2486:PMID
2445:PMID
2401:PMID
2352:PMID
2316:PMID
2267:PMID
2226:PMID
2155:PMID
2097:PMID
2031:PMID
1982:PMID
1964:Cell
1846:VEGF
1844:for
1715:gene
1712:NRP1
1370:8829
753:axon
406:Bgee
354:Band
315:Chr.
253:Band
212:Chr.
174:NRP1
166:2876
146:OMIM
133:NRP1
103:5C7G
99:4RN5
95:4DEQ
91:3I97
87:2QQN
83:2QQM
79:2QQI
75:1KEX
56:RCSB
53:PDBe
22:NRP1
3270:doi
3239:doi
3235:276
3204:PMC
3196:doi
3163:doi
3132:doi
3128:275
3097:doi
3093:275
3062:PMC
3052:doi
3001:doi
2958:doi
2923:PMC
2915:doi
2880:doi
2876:274
2847:doi
2810:doi
2779:doi
2736:doi
2693:doi
2658:doi
2612:PMC
2602:doi
2536:PMC
2528:doi
2476:doi
2435:doi
2391:PMC
2383:doi
2379:164
2306:doi
2257:doi
2216:PMC
2208:doi
2145:PMC
2137:doi
2125:370
2087:doi
2083:277
2021:doi
1972:doi
1817:In
376:End
275:End
178:OMA
154:MGI
46:PDB
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